ライフサイエンスコーパス: CXC chemokine

1 mely, aminoacylation, and as a mimic of host CXC chemokine.

2 phoma 2 (Bcl-2), but reduced serum levels of CXC chemokines.

3 n the lung requires the production of ELR(+) CXC chemokines.

4 ighly potent inhibitors of a range of CC and CXC chemokines.

5 acid insertion (41VSRYR45) relative to other CXC chemokines.

6 growth factor 1 and 5 and of several CC and CXC chemokines.

7 d by a group of chemoattractants, especially CXC chemokines.

8 CXC chemokine administration to the infection site resul

9 a CC chemokine, and interleukin-8 (IL-8), a CXC chemokine, along with their individual interactions

10 CXC chemokines also underwent cleavage by whole GBS cell

11 nfection was enhanced by administration of a CXC chemokine and abrogated by antibodies that blocked t

12 We hypothesized that neutrophil-related CXC chemokines and antimicrobial peptides are increased

13 induction of Th17 signature genes, including CXC chemokines and beta defensin-3.

14 y susceptible to OPC, with reduced levels of CXC chemokines and concomitantly impaired neutrophil rec

15 Although both cytokines regulated CXC chemokines and granulocyte colony-stimulating factor

16 s a means of both activating or inactivating CXC chemokines and inactivating CC chemokines.

17 actor-1alpha (SDF-1alpha) is a member of the CXC chemokines and interacts with the G protein, seven-t

18 nity binding to multiple inflammatory CC and CXC chemokines and is expressed by erythrocytes and endo

19 e objective of this study was to investigate CXC chemokines and its receptor in patients with Behcet'

20 D88/NF-kappaB/AP-1 pathway and production of CXC chemokines and neutrophil infiltration to infected t

21 eparan sulfate inhibited the accumulation of CXC chemokines and neutrophils in tissues and attenuated

22 acerbated disease by impeding the removal of CXC chemokines and neutrophils, whereas administration o

23 ted closely with the removal of tissue-bound CXC chemokines and resolution of accumulated neutrophils

24 a compromised ability to express both CC and CXC chemokines and that this defect is at least partiall

25 prosurvival and proangiogenic role of ELR(+)-CXC chemokines and their receptor CXCR2 during metanephr

26 CXC chemokines and their receptor, CXC chemokine recepto

27 The CXC chemokines and their receptor, CXCR2, are important

28 ression of CXCL2/MIP-2 and CXCL5/LPS-induced CXC chemokine, and activation of NF-kappaB and MAPKs in

29 keratinocyte-derived chemokine, LPS-induced CXC chemokine, and G-CSF were augmented in Adipo(-/-) ve

30 on, bronchoalveolar lavage concentrations of CXC chemokines, and airway hyperreactivity.

31 ities including beta-defensins, ELR-negative CXC chemokines, and the cathelicidin LL-37.

32 hion, vGPCR binds a broad spectrum of CC and CXC chemokines, and the roles of chemokines in vGPCR tum

33 These functions of CXC chemokines are important in the pathogenesis of pulm

34 Because ELR(+) CXC chemokines are important mediators of endothelial-le

35 amic acid-leucine-arginine-positive (ELR(+)) CXC chemokines associated with bronchiolitis obliterans

36 we measured the levels of a panel of CC and CXC chemokines at baseline and following mycobacterial A

37 in scaffold segments necessary for different CXC-chemokine-binding activities, implying that differen

38 ay, we identified and characterized 27 novel CXC-chemokine-binding evasins homologous to EVA3 and def

39 structural and mechanistic insight into how CXC-chemokine-binding tick EVAs achieve class specificit

40 h then induce IL-1R1-dependent production of CXC chemokine by resident corneal fibroblasts.

41 epends at least in part on the production of CXC chemokines by intrinsic renal cells.

42 esangial cells with LPS caused production of CXC chemokines by wild-type cells only.

43 Tick evasins (EVAs) bind either CC- or CXC-chemokines by a poorly understood promiscuous or "on

44 at PE results in increased expression of the CXC chemokines CINC-1 and CINC-2 between 6 and 18 h afte

45 tumor cells constitutively produced the ELC-CXC chemokine CXCL-8 (IL8), enabling them to recruit APR

46 M-1 and VCAM-1), and enhanced the release of CXC chemokine CXCL1 when incubated with primary cultures

47 ny-stimulating factor (G-CSF) and the ELR(+) CXC chemokine CXCL1.

48 The ELR(+) CXC chemokines CXCL1 and CXCL2 are up-regulated in the c

49 ontrast, cathepsins specifically process ELR CXC chemokines CXCL1, -2, -3, -5, and -8 N-terminally to

50 Serum CXC chemokines (CXCL1, CXCL8, CXCL9, CXCL10, CXCL12, CXC

51 Here, we show that the CXC chemokine CXCL4 (PF-4), the most abundant protein co

52 , as was recently reported, for example, for CXC chemokines CXCL4/PF4 and CXCL8/IL8 that interact to

53 We report a novel role for the CXC-chemokine, CXCL5, in the proliferation and invasion

54 tractant 1/CXCL1, lipopolysaccharide-induced CXC chemokine/CXCL5) and up-regulation of the angiogenes

55 and CCL4 are inactive, and the dimer of the CXC chemokine CXCL8 (which is closely related to CXCL1)

56 e up-regulation of three NF-kappaB-regulated CXC-chemokines, CXCL8, CXCL1 and CXCL2, in the resistant

57 e role of non-glutamic acid-leucine-arginine CXC chemokine CXCL9 for T-cell recruitment to prevent re

58 The ELR(-)CXC chemokine CXCL9 is characterized by a long, highly p

59 he interferon-inducible Glu-Leu-Arg-negative CXC chemokines CXCL9, CXCL10, and CXCL11 exhibit antimic

60 inactivate and in some cases degrade non-ELR CXC chemokines CXCL9-12.

61 vaccine that is highly effective in blocking CXC chemokine degradation and permits opsonic Abs to kil

62 Using CXCL12 as a model CXC chemokine, deletion of the X residue (Pro-10) had li

63 zation motifs represented by CC-chemokine or CXC-chemokine dimer interfaces.

64 d infection through enhancement of the local CXC chemokine-driven neutrophil response.

65 demonstrate that early, local treatment with CXC chemokines enhances neutrophil recruitment and clear

66 y diseases, we sought to further unravel the CXC-chemokine-EVA interactions.

67 n vitro analysis demonstrated that all three CXC chemokines exerted direct antimicrobial effects agai

68 ages and epithelial cells, which facilitates CXC chemokine expression and aids neutrophil recruitment

69 onfirmed the importance of IL-1 signaling in CXC chemokine expression and neutrophil recruitment in v

70 The mutation was linked to modestly impaired CXC chemokine expression and neutrophil recruitment to t

71 L-1beta signaling or IL-17 signaling reduced CXC chemokine expression but did not alter the overall s

72 We also found that MIF induced angiogenic CXC chemokine expression in an autocrine manner in vitro

73 ed with the angiogenic activity and level of CXC chemokine expression in human specimens of non-small

74 itro and in vivo models indicate that ELR(+) CXC chemokine expression is higher in microvascular endo

75 eloid expression of CXCR2 directly regulated CXC chemokine expression levels after hepatic I/R, such

76 on reduces RSV-induced neutrophilia, mucosal CXC chemokine expression, activation of the IRF7-RIG-I a

77 The CXC chemokine family is a pleiotropic family of cytokine

78 In this study, ELR(+)-CXC chemokine family members CXCL2 and CXCL7, along with

79 In this Review, we discuss the biology of CXC chemokine family members, specifically as it relates

80 mokine receptor that binds to members of the CXC chemokine family possessing angiogenic properties.

81 tivating peptide-78 (CXCL5), a member of the CXC chemokine family, has been shown to be involved in a

82 o be described and is the 17th member of the CXC chemokine family.

83 ment of CXCR2, the receptor for ELR-positive CXC chemokines, for RV-induced airway neutrophilia and h

84 revealed lower expression levels of several CXC chemokine genes (CXCL-1, -2, -3, -5, -6, -12) in CWF

85 As exemplified by the CXC chemokine genes clustered on chromosome 4, we demons

86 CXC chemokine genes showed the highest degrees of connec

87 virulence by facilitating the generation of CXC chemokine gradients and stimulating chemokine-induce

88 and demonstrated that it readily cleaved the CXC chemokines GRO-alpha, GRO-beta, GRO-gamma, neutrophi

89 lished the abilities of three representative CXC chemokines, GRO-gamma, NAP-2, and GCP-2, to attract

90 detected by Sytox green staining, levels of CXC chemokines, histones, and cytokines also were measur

91 equivalently binds four different ELR-devoid CXC chemokines (ie, PF4/CXCL4, IP-10/CXCL10, MIG/CXCL9,

92 higher levels of tumor-associated angiogenic CXC chemokines (ie, the ELR score) and greater vasculari

93 ses (MMP-9, ADAM-8), CC chemokines (CCL-20), CXC chemokines (IL-8, CXCL-10, CXCL-11), oligoadenylate

94 ression of CXCL2/MIP-2 and CXCL5/LPS-induced CXC chemokine in Klebsiella-infected lungs, and 2) CXCL1

95 pression of a variety of inflammatory CC and CXC chemokines in all models.

96 re, we analyzed expression of genes encoding CXC chemokines in M. tuberculosis-infected murine lung t

97 A systemic derangement of CXC chemokines in maternal and fetal circulation disting

98 not TLR2-deficient mesangial cells produced CXC chemokines in response to stimulation with Pam(3)Cys

99 To prove the role of CXC chemokines in the augmented inflammation, CXC chemok

100 icantly lower concentrations of PMN-specific CXC chemokines in wound tissue than did WT mice.

101 l-derived chemokines, MIP-2, and LPS-induced CXC chemokines) in the lungs.

102 he second class bound both ELR(+) and ELR(-) CXC-chemokines, in several cases including CXC-motif che

103 As a result, CXC chemokines increase in lung, setting the stage for n

104 When given immediately after CLP, CXC chemokines increased peritoneal neutrophil recruitme

105 Similarly, CXC chemokines induce biological responses through the m

106 potentiation of neutrophil mobilization via CXC chemokine induction is a putative mechanism underlyi

107 s would increase neutrophil migration toward CXC chemokines instilled into lungs of mice.

108 Production of the CXC chemokine interleukin (IL)-8/CXCL8 forms a common ep

109 s one of two high-affinity receptors for the CXC chemokine interleukin-8 (IL-8), a major mediator of

110 in kinases, and basolateral secretion of the CXC chemokine interleukin-8 (IL-8).

111 Local expression of CXC chemokines is critical for PMN recruitment.

112 Local lung production of CXC chemokines is intensified during experimental sepsis

113 lumican and keratocan core proteins bind the CXC chemokine KC during a corneal inflammatory response,

114 e susceptibility of C3H-HeN mice lacking the CXC chemokine KC or its receptor CXC receptor 2 (CXCR2)

115 dentium-stimulated induction of iNOS and the CXC chemokines KC and MIP-2 to the same degree as the NF

116 ed attenuation of expression of iNOS and the CXC chemokines KC and MIP-2.

117 However, high levels of CXC chemokines (KC and MIP-2), particularly at later tim

118 oid A and IL-6, and the neutrophil-selective CXC chemokines, KC and macrophage inflammatory protein-2

119 A comparison of the murine CXC chemokines, KC and MIP-2, revealed that KC was more

120 Levels of the CXC chemokines keratinocyte-derived chemokine and macrop

121 ere were no differences in the levels of the CXC chemokines keratinocyte-derived chemokine and MIP-2

122 hrough increased pulmonary expression of the CXC chemokines (keratinocyte-derived chemokine and macro

123 rived cells in the corneal stroma to produce CXC chemokines, leading to neutrophil recruitment to the

124 Increased CXC chemokine levels were associated with significantly

125 hagocytosis, and decreased IL-6 and MIP-2 (a CXC chemokine) levels after CLP in outbred (ICR/CD-1) mi

126 pon stimulation with CCL2, CCL19, CCL21, and CXC chemokine ligand (CXCL) 12 (DCs).

127 (CXCR) 4 in response to its natural ligands CXC chemokine ligand (CXCL) 12 and macrophage migration

128 Microarray analysis of CXC chemokine ligand (CXCL) 12-treated T cells revealed

129 The CXC chemokine ligand (CXCL) 12/CXC chemokine receptor (C

130 The urinary CXC chemokine ligand (CXCL)10 detects renal transplant i

131 Aberrant expression of the chemokine CXC chemokine ligand (CXCL)10 has been linked to the sev

132 em cells (MSCs) and their progeny, including CXC chemokine ligand (CXCL)12-abundant reticular (CAR) c

133 rophages and mesenchymal progenitors such as CXC chemokine ligand (CXCL)12-abundant reticular (CAR) c

134 ide evidence supporting functional roles for CXC chemokine ligand (CXCL)13 and interleukin (IL)-10 in

135 ligand (CCL)2, CCL3, CCL5, CCL19, CCL20, and CXC chemokine ligand (CXCL)8 were measured in gingival t

136 The CXC chemokine ligand (CXCL12, or stromal cell-derived fa

137 rum levels of interleukin-6, interleukin-10, CXC chemokine ligand 1, and interferon-gamma were signif

138 ed into murine lung, leading to induction of CXC chemokine ligand 1/2 and a neutrophilic response tha

139 [MHV]) expressing the T-cell chemoattractant CXC chemokine ligand 10 (CXCL10) resulted in increased s

140 The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor

141 uch as interferon-gamma-inducible protein 10/CXC chemokine ligand 10, interleukin 8, and monocyte che

142 nformations compared with the CXCR3 agonists CXC chemokine ligand 11 (CXCL11), VUF11418 [1-((1R,5S)-6

143 onse correlates with enhanced sensitivity to CXC chemokine ligand 12 (CXCL12) but not CXCL13 or CC ch

144 receptor 4 (CXCR4) in Cajal-Retzius cells by CXC chemokine ligand 12 (CXCL12) is important for contro

145 emokine receptor 4 (CXCR4), is selective for CXC chemokine ligand 12 (CXCL12), is broadly expressed i

146 ling postnatal HSCs expressed high levels of CXC chemokine ligand 12 (CXCL12, also known as stromal c

147 stromal cell-derived factor-1 (SDF-1alpha or CXC chemokine ligand 12) are involved in the trafficking

148 A-1 molecules upon stimulation with CXCL-12 (CXC chemokine ligand 12).

149 CXC chemokine ligand 13 (CXCL13), CC chemokine ligand 21

150 GR) recruitment to the neutrophil chemokine, CXC chemokine ligand 5 (CXCL5), providing a candidate me

151 lowered rolling velocity further and induced CXC chemokine ligand-1 (CXCL1) and CXC chemokine recepto

152 CXC chemokine ligand-13 (CXCL13) has been implicated in

153 aortic wall and impaired local production of CXC-chemokine ligand (CXCL) 2.

154 vels of chemokines CC chemokine ligand 5 and CXC-chemokine ligand 4 were increased in the trJAM-A(-/-

155 CXC-chemokine ligand 9 (CXCL9) is an interferon-inducibl

156 ysaccharide-stimulated human MPhi identified CXC chemokine ligands (CXCLs), such as IP-10 (interferon

157 ize neutrophil chemoattractants CXCL1/CXCL2 (CXC chemokine ligands 1/2) in response to LPS.

158 TOF MS identified two differential proteins: CXC chemokine ligands 4 (CXCL4) and 7 (CXCL7), both of w

159 ne gene transcript levels of multiple CC and CXC chemokine ligands and receptors.

160 We found no effects of MMP-8 on LPS-induced CXC chemokine (LIX, or CXCL5)-induced neutrophil recruit

161 is associated with the local release of the CXC chemokines macrophage inflammatory protein 2 and KC.

162 In addition, mRNA levels of the CXC chemokines macrophage inflammatory protein 2 and ker

163 CXC chemokines, many of which can recruit neutrophils to

164 Pseudomonas and the ELR(+) CXC chemokines may interact to negatively influence lung

165 CXC chemokines mediate hepatic inflammation and injury f

166 oblasts and our previous studies showed that CXC chemokines mediate neutrophil recruitment, we examin

167 strating that IL-13 stimulates select CC and CXC chemokines (MIP-1alpha/CCL-3, MIP-1beta/CCL-4, MIP-2

168 matory cytokines (lipopolysaccharide-induced CXC chemokine, monocyte chemotactic protein-1, macrophag

169 Pulmonary levels of the CXC chemokines, monocyte inflammatory protein-2 and KC,

170 However, direct effects of CXC chemokines on hepatocytes during this response have

171 s in the production of MIP-2 and LPS-induced CXC chemokine or activation of NF-kappaB and MAPKs in th

172 ly induced in the colon by infection encoded CXC chemokines, particularly CXCL1/2/5 and CXCL9/10, whi

173 Our findings reveal that a Th17-ELR(+) CXC chemokine pathway is critical for granulocyte mobili

174 cine-arginine (ELR) tripeptide motif (ELR(+) CXC chemokines) play an important role in leukocyte traf

175 lphabetaTCR+ cells and functions to regulate CXC chemokine production and neutrophil recruitment in v

176 ings indicate that IL-1R1 and MyD88 regulate CXC chemokine production and neutrophil recruitment to t

177 rTNF-alpha, rIL-1alpha, or rIL-1beta induced CXC chemokine production by corneal fibroblasts but not

178 We found no effect of rIFN-gamma on CXC chemokine production by macrophages or corneal fibro

179 TLR2 expression was also essential for CXC chemokine production by resident cells in the cornea

180 Eritoran tetrasodium significantly inhibited CXC chemokine production in the cornea and development o

181 Wild-type serotype Typhi induces less CXC chemokine production in tissue culture models than d

182 Low shear activated endothelial ELR(+) CXC chemokine production via cell surface heparan sulfat

183 alization, patterns of neutrophil influx and CXC chemokine production were assessed in C57Bl/6 mice a

184 The immunomodulatory effects of PEP35 on CXC chemokine production were TLR2 and NF-kappaB depende

185 naling in alveolar macrophages, resulting in CXC chemokine production, and C5a appears to play a pivo

186 in S. aureus infections in controlling local CXC chemokine production, neutrophil recruitment to the

187 s CCL5, they exhibit significantly increased CXC chemokine production, neutrophil recruitment to the

188 es, inflammatory cell recruitment, and local CXC chemokine production.

189 ance of the type I IFN inhibitory pathway on CXC chemokine production.

190 ced neutrophil recruitment or on LPS-induced CXC chemokine production.

191 a, IL-6, and LIX (lipopolysaccharide-induced CXC chemokine) production were attenuated in the lungs o

192 n transcript levels of genes encoding CC and CXC chemokines, proinflammatory cytokines, and TNF super

193 of the type IV collagen, thrombospondin, and CXC chemokine protein families, as well as somatotropin

194 eceptors, only CC chemokine receptor (CCR5), CXC chemokine receptor (CXCR) 3, and CXCR6 correlated wi

195 ein modifier inside the cell, functions as a CXC chemokine receptor (CXCR) 4 agonist outside the cell

196 ied extracellular ubiquitin as an endogenous CXC chemokine receptor (CXCR) 4 agonist.

197 r ubiquitin has recently been described as a CXC chemokine receptor (CXCR) 4 agonist.

198 The CXC chemokine ligand (CXCL) 12/CXC chemokine receptor (CXCR) 4 axis represents a well-e

199 G(+) plasma cells accompanied by defects in CXC chemokine receptor (CXCR) 4 expression, interleukin

200 activation and early signaling steps of the CXC chemokine receptor (CXCR) 4 in response to its natur

201 CXC chemokine receptor (CXCR)4 is an HIV coreceptor and

202 ween stromal cell-derived factor (SDF)-1 and CXC chemokine receptor (CXCR)4.

203 We found that mice lacking the type 2 CXC chemokine receptor (CXCR2) were relatively resistant

204 de neutrophils to sites of liver necrosis by CXC chemokine receptor 2 (CXCR2) and formyl peptide rece

205 flammation through activation of endothelial CXC Chemokine Receptor 2 (CXCR2) and production of endot

206 the alpha(1A)-adrenoceptor (alpha(1A)AR) and CXC chemokine receptor 2 (CXCR2) in live cells.

207 Our aim was to discover the role of IL-17, CXC chemokine receptor 2 (CXCR2) ligands, and cancer-ass

208 In models of acute lung injury, CXC chemokine receptor 2 (CXCR2) mediates migration of p

209 We also found that neither CXC chemokine receptor 2 (CXCR2) nor interleukin-17 (IL-

210 ound lymphotoxin-beta receptor (LTbetaR) and CXC chemokine receptor 2 (CXCR2), is involved in type B

211 oid cells was reduced using an antagonist of CXC chemokine receptor 2 (CXCR2).

212 The CXC chemokine ligand 10 (CXCL10)/CXC chemokine receptor 3 (CXCR3) chemokine pathway promo

213 CXC chemokine receptor 3 (CXCR3) ligands CXCL9 and CXCL1

214 gamma is required for efficient induction of CXC chemokine receptor 3 (CXCR3) on T cells upon activat

215 The interaction of the CXC chemokine receptor 3 (CXCR3) receptor with its ligan

216 CXC chemokine receptor 3 (CXCR3) signaling promotes kera

217 CXC chemokine receptor 3 (CXCR3)-expressing B cells were

218 tosis of hepatocytes involving TLR4, but not CXC chemokine receptor 3 signaling.

219 mulated MPhi of chemoattractant activity for CXC chemokine receptor 3-transfected (receptor for IP-10

220 ow that extracellular ubiquitin is a natural CXC chemokine receptor 4 (CXCR4 and CD184) agonist.

221 The two CXC-type chemokine receptors, CXC chemokine receptor 4 (CXCR4) and atypical chemokine

222 The CXC chemokine receptor 4 (CXCR4) and its ligand, stromal

223 ll-derived factor-1 (SDF-1) and its receptor CXC chemokine receptor 4 (CXCR4) are important regulator

224 We identify CXC chemokine receptor 4 (CXCR4) as a receptor used by a

225 CXC chemokine receptor 4 (CXCR4) blockade promotes T cel

226 romal cell-derived factor 1 and its receptor CXC chemokine receptor 4 (CXCR4) critically mediate the

227 The CXC chemokine receptor 4 (CXCR4) for the chemokine (C-X-

228 Activation of the CXC chemokine receptor 4 (CXCR4) in Cajal-Retzius cells

229 CXC chemokine receptor 4 (CXCR4) is a G protein-coupled

230 38+ cells in the blood, higher leukemic cell CXC chemokine receptor 4 (CXCR4) levels, and increased r

231 CXC chemokine receptor 4 (CXCR4) plays a role in the dev

232 The stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signaling axis appears

233 CXC chemokine receptor 4 (CXCR4), initially linked with

234 The chemokine receptor, CXC chemokine receptor 4 (CXCR4), is selective for CXC c

235 gous to the V3 loop of HIV-1, which binds to CXC chemokine receptor 4 (CXCR4), we hypothesized that B

236 ations covering all 352 residues of the GPCR CXC chemokine receptor 4 (CXCR4), we identified 41 amino

237 somal dominant gain-of-function mutations in CXC chemokine receptor 4 (CXCR4).

238 erived factor-1 alpha (CXCL12/SDF-1) via the CXC chemokine receptor 4 (CXCR4).

239 cluding integrin beta1, integrin alpha4, and CXC chemokine receptor 4 (CXCR4).

240 hereas 26%-73% of cells coexpressed CCR5 and CXC chemokine receptor 4 (CXCR4).

241 imerization among known GPCR homodimers: the CXC chemokine receptor 4 and sphingosine-1-phosphate rec

242 We observe that CXC chemokine receptor 4 and sphingosine-1-phosphate rec

243 a promising protein therapeutic and implies CXC chemokine receptor 4 as a drug target after polytrau

244 cell-derived factor 1alpha and its receptor CXC chemokine receptor 4 in beta-selection.

245 Disrupting homing dynamics with a CXC chemokine receptor 4 inhibitor reduced the formation

246 Plasma levels of the cognate CXC chemokine receptor 4 ligand stromal cell-derived fac

247 vels and corresponding surface expression of CXC chemokine receptor 4 on clonal PCs, suggesting that

248 The HIV envelope glycoprotein interacts with CXC chemokine receptor 4 to activate the lysosomal degra

249 stem cell mobilizer or its receptor, CXCR4 (CXC chemokine receptor 4), would attenuate and reverse h

250 s, such as protease-activated receptor 1 and CXC chemokine receptor 4, RGS4 disrupted Rac1-dependent

251 growth factor receptor and G-protein-coupled CXC chemokine receptor 4.

252 bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis,

253 ided in the T cell areas, expressed CCR7 and CXC chemokine receptor 5 (CXCR5), and like follicular he

254 y modified unselected CD8 T cells to express CXC chemokine receptor 5 (CXCR5), the chemokine receptor

255 ssion of B-cell leukemia/lymphoma 6 (Bcl-6), CXC chemokine receptor 5, programmed death-1, and other

256 The CXC chemokine receptor CXCR2 and its specific ligands ha

257 CXC chemokine receptor CXCR3 and/or its main three ligan

258 m kinase ERK also in the presence of BCR and CXC chemokine receptor CXCR4 stimulation.

259 ion to formulate a basis for the function of CXC chemokine receptor signaling in hepatocytes.

260 derstanding of the pathways involved in both CXC chemokine receptor signaling in other cell types, mo

261 e evaluated their inhibitory activity on the CXC chemokine receptor type 4 (CXCR4), toxicity properti

262 We found that the CXC chemokine receptor type 4 accommodated the results b

263 CXC chemokine receptor-2 (CXCR2) has been shown to play

264 ed the significance of signaling through the CXC chemokine receptor-2 (CXCR2) receptor in the process

265 More recently, signaling through CXC chemokine receptor-2 (CXCR2) was shown to delay live

266 CXC chemokines and their receptor, CXC chemokine receptor-2 (CXCR2), are important componen

267 d induced CXC chemokine ligand-1 (CXCL1) and CXC chemokine receptor-2 (CXCR2)-dependent leukocyte arr

268 tic parental cells (686LN-Ps), we found that CXC chemokine receptor-4 (CXCR4) mRNA levels were signif

269 ral differentiation, we observed that CXCR4 (CXC chemokine receptor-4) expressing central nervous sys

270 ce markers of neutrophils (Ly6G, L-selectin, CXC chemokines receptor 2, and 7/4) and DCs (CD11c, MHC

271 ection within the liver was not dependent on CXC-chemokine receptor 2 (CXCR2) signaling as anti-CXCR2

272 CXC-chemokine receptor 4 (CXCR4) is a G protein-coupled

273 The chemokine receptor CXC-chemokine receptor 4 (CXCR4) is a transmembrane rece

274 CXC-chemokine receptor 4 (CXCR4) regulates the retention

275 The antagonism of CXC-chemokine receptor 4 (CXCR4) with AMD3100 improves c

276 iae lacking FimCDE fail to interact with the CXC-chemokine receptor 4 (CXCR4), and bacteria expressin

277 Recent crystal and NMR structures of the CXC chemokine receptors (CXCR) CXCR4 and CXCR1, combined

278 s known about the signaling pathways used by CXC chemokine receptors in hepatocytes.

279 "minor pocket," previously characterized in CXC chemokine receptors-1 and -2, is functionally conser

280 he nucleus, transcription of CXCL1 and other CXC chemokines, recruitment of neutrophils to the cornea

281 hereas T(H)17 transfer resulted in increased CXC chemokine secretion and neutrophil influx that was n

282 ne-cytokine receptor interaction (especially CXC-chemokine) signaling as well as cancer-related pathw

283 XC chemokines in the augmented inflammation, CXC chemokine-specific antibodies were delivered to the

284 ports indicate that interactions between the CXC chemokine stromal cell-derived factor 1 and its rece

285 protein 2) and CXCR4 (specific receptor for CXC chemokine stromal cell-derived factor-1) in CLL cell

286 The CXC chemokine stromal cell-derived factor-1alpha (SDF-1)

287 The human CXC chemokine, stromal cell-derived factor 1 (SDF-1alpha

288 Stromal Cell-derived factor 1 (SDF-1) is a CXC chemokine that binds to the CXCR4 receptor.

289 related with the strain's ability to degrade CXC chemokines, thereby preventing neutrophil chemotaxis

290 Intragraft production of CXC chemokines was measured by Luminex and enzyme-linked

291 Although the expression of CXC chemokines was modestly up-regulated in ECs, the exp

292 erferon-inducible Glu-Leu-Arg (ELR)-negative CXC chemokines was not affected by the BaPGN-induced ant

293 Expression of 11 of the 16 known human CXC-chemokines was increased in lung adenocarcinoma cell

294 neutrophil influx (along with expression of CXC chemokines) was significantly enhanced in infected t

295 TNF-alpha and CXC chemokines were detected in mast cell supernatants a

296 ents, plasma levels of CXCL5, another ELR(+) CXC chemokine, were elevated during acute lesion formati

297 hich included EVA3, exclusively bound ELR(+) CXC-chemokines, whereas the second class bound both ELR(

298 GRO-alpha is a CXC chemokine with tumor-associated angiogenic as well a

299 CXC chemokines with a glutamate-leucine-arginine (ELR) t

300 the co-expression of MIF-CD74 and angiogenic CXC chemokines with tumor angiogenesis.