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1                                              CYP11A1 (rate-limiting enzyme) was expressed in cancerou
2                                              CYP11A1 and CYP27A1 hydroxylate tachysterol(3) , a photo
3                                              CYP11A1 expression was stable, CYP17A1 increased, and HS
4                                              CYP11A1 is involved in the first step in the steroidogen
5                                              CYP11A1 primarily binds its substrate 20R,22R-dihydroxyc
6                                              CYP11A1, CYP17A1, HSD3beta, and HSD17beta3 were identifi
7          Mitochondrial cytochrome P450 11A1 (CYP11A1 or P450 11A1) is the only known enzyme that clea
8 two membrane proteins, cytochrome P450 11A1 (CYP11A1) and adrenodoxin reductase (AdR).
9 R), cytochrome P450 family 11, subfamily A1 (CYP11A1) and 3 beta-hydroxysteroid dehydrogenase type 1
10                     The ability of adipocyte CYP11A1 in producing pregnenolone is demonstrated for th
11 eurosteroids such as CYP46A1, 3alphaHSD, and CYP11A1.
12  reduced androgen biosynthesis and CYP17 and CYP11A1 mRNA when added to the medium of cultured PCOS t
13 in a PCOS phenotype of augmented CYP17A1 and CYP11A1 gene transcription, mRNA abundance, and androgen
14 educed androgen biosynthesis and CYP17A1 and CYP11A1 gene transcription.
15 xides induced spectral shifts in CYP27A1 and CYP11A1 but glycol metabolites were detected only with C
16  25-hydroperoxide to the enzymes CYP27A1 and CYP11A1 induced well-defined spectral changes while gene
17 t alter synthesis, indicating use of another CYP11A1 isoform is unlikely.
18 ightly associated with the membrane, such as CYP11A1, can be quantified in the total tissue membrane
19                  An epistatic effect between CYP11A1 and VDR polymorphisms may contribute to the pred
20 the context of a modeled interaction between CYP11A1 and the reduced (functional) form of Adx in whic
21 gated whether there exist contact(s) between CYP11A1 and Adx that are differentially influenced by ch
22 be the metabolism of 7-dehydrocholesterol by CYP11A1 to a single product identified as 7-dehydropregn
23 ined, the rate with which they are formed by CYP11A1 in vitro suggests an important role.
24 oduction in glial cells was not inhibited by CYP11A1 inhibitors DL-aminoglutethimide and ketoconazole
25 rocholesterol (7DHC) metabolism initiated by CYP11A1 and previously characterized in vitro, occur in
26 ctivation have been discovered, initiated by CYP11A1 and/or CYP27A1 in the case of L3 and T3.
27 novel pathways of D3 metabolism initiated by CYP11A1, with the product profile showing organ/cell typ
28      Although pregnenolone is synthesized by CYP11A1 in peripheral steroidogenic organs, our recent s
29 red for androgen synthesis from cholesterol (CYP11A1, CYP17A1, HSD3beta, HSD17beta3) were investigate
30 m pathways with highly negatively correlated CYP11A1 and CYP1B1 expression in breast tissue from post
31 nd M77S and mutagenesis of the corresponding CYP11A1 contact (W418A) revealed differential effects to
32     mRNA levels of CGA, CGB, PPARG, CYP19A1, CYP11A1, PTGS2, EREG, and the intracellular beta subunit
33                        Additionally, CYP7A1, CYP11A1, CYP27A1, and CYP46A1 are parts of a broader cho
34 CPR and FdR) and tightly associated (CYP7B1, CYP11A1, CYP27A1, and CYP46A1) membrane proteins were qu
35                    Among mitochondrial CYPs, CYP11A1 catalyzes both cholesterol side-chain cleavage,
36 ygen species, (2) metabolism via a different CYP11A1 isoform, and (3) metabolism via another CYP450 e
37  steroidogenesis pathway initiated by enzyme CYP11A1, and via the acidic bile acid pathway, which is
38 ntial actions of the cytochrome P450 enzymes CYP11A1 and CYP17A1, so that CYP17A1 inhibitors such as
39       In contrast, the steroidogenic enzymes CYP11A1 and CYP11B1 involved in glucocorticoid biosynthe
40 n in expression of the steroidogenic enzymes CYP11A1, CYP17A1 and HSD17B3, and of INSL3.
41 YP51 reaction, as previously established for CYP11A1 and CYP19A1.
42 ubstrate-specific contacts are important for CYP11A1 monooxygenation of vitamin D3 or side chain clea
43 ween genotypes of the cytochrome P-450 genes CYP11A1 (-528[TTTTA]n) or CYP17A1 (-34T/C) or the 17beta
44 SLC2A1, CYP17A1, RB1, IDS, GUSB, DMD, GLUD1, CYP11A1, GALNS, CPS1, PLPBP, ALDH7A1, SLC26A3, SLC25A15,
45     In placenta and adrenal glands with high CYP11A1 expression, the predominant pathway was D3 --> 2
46 ite the absence of observable immunoreactive CYP11A1 protein.
47                    The active site cavity in CYP11A1 represents a long curved tube that extends from
48 ed (functional) form of Adx in which Adx M77-CYP11A1 W418 is the driving constraint.
49  controlling endogenous estrogen metabolism, CYP11A1 harbors common variants that may influence expre
50    Comparisons with cholesterol-metabolizing CYP11A1 and cortisol-producing CYP11B1, which also bind
51 dies have shown that substrates can modulate CYP11A1 protein-protein interactions with the redox part
52                 Thus, we have detected novel CYP11A1-derived secosteroids in the skin, serum and adre
53 lt, protein levels and enzymatic activity of CYP11A1, a steroidogenic enzyme regulating CD8(+) T-cell
54 ing the primary defect was the deficiency of CYP11A1.
55 nt neurosteroids in the brain, expression of CYP11A1 is difficult to detect.
56 renodoxin is also an allosteric modulator of CYP11A1 substrate binding.
57                    Second, overexpression of CYP11A1 isoform b did not alter synthesis, indicating us
58                                  Products of CYP11A1 action on 7DHC, namely 22(OH)7DHC, 20,22(OH)27DH
59          We have compared quantifications of CYP11A1 using two different detergents, RapiGest SP and
60 n, we present the 2.5-A crystal structure of CYP11A1 in complex with the first reaction intermediate,
61 rome P450 side-chain cleavage enzyme (SCC or CYP11A1) catalyzes cholesterol to pregnenolone conversio
62 the steroidogenic enzyme cytochrome P450scc (CYP11A1) as well as CYP27B1 (1alpha-hydroxylase).
63                          Cytochrome P450scc (CYP11A1) catalyzes conversion of cholesterol (CH) to pre
64 g purified mitochondrial cytochrome P450scc (CYP11A1) reconstituted with the iron-sulfer protein, adr
65 xpression of the steroidogenic gene products CYP11A1 and StAR in both H295R adrenal and MA-10 Leydig
66 ence that the circadian network may regulate CYP11A1 activity and by inference, the production of dow
67 gens and estrogens from cholesterol requires CYP11A1 and CYP17A1.
68 eins was reduced during EAE, including StAR, CYP11A1, CYP17A1 and HSD3B.
69 l cytochrome P450 (CYP450) enzyme other than CYP11A1 in human glial cells.
70 ochondrial cytochrome P450 enzyme other than CYP11A1 in human glial cells.
71                      These data suggest that CYP11A1 protein-protein interactions with Adx are unique
72                                          The CYP11A1 gene encodes the cholesterol side chain cleavage
73                                          The CYP11A1-22HC co-complex also provides insight into the s
74  major steroid precursor pregnenolone by the CYP11A1 enzyme.
75                In contrast, silencing of the CYP11A1 gene did not affect marinobufagenin production i
76 characterize the genetic architecture of the CYP11A1 gene in a Chinese study population.
77 tion of the role of genetic variation of the CYP11A1 gene in breast cancer risk in a study of 1193 br
78  mitochondrial P450, P450scc (product of the CYP11A1 gene).
79 Local androgen regulation in the skin of the CYP11A1 gene, which encodes a crucial enzyme that metabo
80                                 Overall, the CYP11A1 and AdR quantified in this work ranged from 110
81 ix-3 as a substrate-specific contact towards CYP11A1.
82 l steroid dependent and mediated by upstream CYP11A1-dependent intraturmoral pregnenolone/progesteron
83 expression was significantly correlated with CYP11A1 (P = 0.0009), HSD3beta (P = 0.0297), and HSD17be
84 ced experimentally: MnBP with CGA, MBzP with CYP11A1, and MEHP with PTGS2.
85 t glycol metabolites were detected only with CYP11A1.