ライフサイエンスコーパス: Cajal

1 f gut pacemaker cells (interstitial cells of Cajal).

2 ocated on non-neuronal interstitial cells of Cajal.

3 ct and arises from the interstitial cells of Cajal.

4 ated near Kit-positive interstitial cells of Cajal.

5 tor nucleus, and the interstitial nucleus of Cajal.

6 stricted to muscle and interstitial cells of Cajal.

7 ince the pioneering work of Santiago Ramon y Cajal.

8 d gametogenesis and in interstitial cells of Cajal.

9 system, including the interstitial cells of Cajal.

10 described more than 100 years ago by Ramon y Cajal.

11 s of muscle fibers and interstitial cells of Cajal.

12 ons, smooth muscle, or interstitial cells of Cajal.

13 in enteric neurons or interstitial cells of Cajal.

14 also projects to the commissural nucleus of Cajal, a general visceral sensory center.

15 plexus, had functional interstitial cells of Cajal and had an electromechanical coupling that regulat

16 on points to a role of interstitial cells of Cajal and mast cells.

17 volutionized at the meso- and microlevels by Cajal and others in the late nineteenth century, and rea

18 Intramuscular interstitial cells of Cajal and platelet-derived growth factor receptor alpha-

19 membraneless organelles, including nucleoli, Cajal and PML bodies, and stress granules.

20 ules in neurons, glia, interstitial cells of Cajal, and muscularis macrophages.

21 ns, were first described by Santiago Ramon y Cajal as "protoplasmic kisses that appear to constitute

22 vel, the importance of interstitial cells of Cajal as pacemakers, neuromodulators and stretch recepto

23 Interstitial cells of Cajal at the level of the deep muscular plexus (ICC-DMP)

24 ole of mouse Drp2 in apposition assembly and Cajal band function and compared it with periaxin.

25 Cajal bands are cytoplasmic channels flanked by appositi

26 Loss of periaxin disrupts appositions and Cajal bands in Schwann cells and causes a severe demyeli

27 e 1), drives phosphorylation of NDRG1 in the Cajal bands of the abaxonal compartment.

28 Schwann cells have disrupted appositions and Cajal bands, and they undergo focal hypermyelination and

29 anvier, the Schmidt-Lanterman incisures, and Cajal bands.

30 aparanodes, Schmidt-Lanterman incisures, and Cajal bands.

31 of myelin decompaction, a reduced number of Cajal bands.

32 ), nuclear speckles (27), paraspeckles (24), Cajal bodies (17), Sam68 nuclear bodies (5), Polycomb bo

33 (ugAG) required for targeting of scaRNAs to Cajal bodies (CB) and an uncharacterized sequence requir

34 lear phosphoprotein that concentrates within Cajal bodies (CBs) and impacts small nuclear ribonucleop

35 Cajal bodies (CBs) are nuclear organelles concentrating

36 Cajal bodies (CBs) are nuclear organelles that occur in

37 Cajal bodies (CBs) are nuclear suborganelles that nonran

38 The nucleolus and Cajal bodies (CBs) are prominent interacting subnuclear

39 Cajal bodies (CBs) are subnuclear domains involved in th

40 cs and photoactivation experiments of hTR in Cajal bodies (CBs) reveal that hTERT controls the exit o

41 n roles in RNA metabolism, the nucleolus and Cajal bodies (CBs), both located within the nucleus, are

42 role of various nuclear organelles, such as Cajal bodies (CBs), in their nuclear maturation phase ha

43 re we examined the non-random positioning of Cajal bodies (CBs), major NBs involved in spliceosomal s

44 Coilin is known as the marker protein for Cajal bodies (CBs), subnuclear domains important for the

45 Coilin protein scaffolds Cajal bodies (CBs)-subnuclear compartments enriched in s

46 displacements of coilin and SMN proteins in Cajal bodies and direct dissociation of coilin-SMN assoc

47 ompartments including chromosomes, nucleoli, Cajal bodies and histone locus bodies.

48 AIDA-1d to the nucleus, where it couples to Cajal bodies and induces Cajal body-nucleolar associatio

49 replaces NAF1 to yield mature H/ACA RNPs in Cajal bodies and nucleoli.

50 eins potentially involved in the assembly of Cajal bodies and paraspeckles.

51 uggest that the trafficking of telomerase to Cajal bodies and telomeres in cancer cells correlates wi

52 The localization of hTR to Cajal bodies and telomeres is specific to cancer cells w

53 cancer cells leads to loss of hTR from both Cajal bodies and telomeres without affecting hTR levels.

54 l cycle, accompanied by its concentration in Cajal bodies and transient colocalization with telomeres

55 Intracellular bodies such as nucleoli, Cajal bodies and various signalling assemblies represent

56 Cajal bodies are believed to be the storage and processi

57 Cajal bodies are conserved sites for the maturation of r

58 Cajal bodies are nuclear sites of small ribonucleoprotei

59 Cajal bodies are nuclear structures that host RNA modifi

60 Our results suggest a function for Cajal bodies as a center for the assembly of an AGO4/NRP

61 olocalize to small nuclear bodies similar to Cajal bodies but lacking the Cajal body marker Atcoilin.

62 the trafficking of hTR to both telomeres and Cajal bodies depends on hTERT.

63 Other protein pairs in Cajal bodies exhibit different magnitudes of fluorescenc

64 inhibitor Imetelstat (GRN163L), a time when Cajal bodies fail to deliver telomerase RNA to telomeres

65 s, scaRNAs, and snRNAs-that are dependent on Cajal bodies for stability and activity.

66 ides localized in close proximity to nuclear Cajal bodies in telomerase-positive cells.

67 ult implies that processing of telomerase by Cajal bodies may affect its processivity.

68 t structural changes of protein complexes in Cajal bodies may represent a unique mechanism of mechano

69 We used the accumulation of SMN in Cajal bodies of intact proliferating cells, which active

70 localized to the nucleoplasm, nucleoli, and Cajal bodies of transfected cells.

71 on factor NPAT in subnuclear foci, including Cajal bodies that associate with histone gene clusters.

72 protein localized primarily in nucleoli and Cajal bodies that was identified as a downstream target

73 jal bodies, while others must concentrate in Cajal bodies to function.

74 ogated, because telomerase mislocalizes from Cajal bodies to nucleoli within the iPSCs.

75 ce analyses, all 3 sera showed nuclear dots (Cajal bodies) and cytoplasmic staining.

76 he endogenous FRG1 is localized in nucleoli, Cajal bodies, and actively transcribed chromatin; howeve

77 pathway for enzyme assembly, localization in Cajal bodies, and association with telomeres.

78 n discrete organelles that include speckles, Cajal bodies, and histone locus bodies.

79 plicing factors and the telomerase enzyme to Cajal bodies, and its functional loss has been linked to

80 lex, its intracellular trafficking involving Cajal bodies, and its recruitment to telomeres.

81 ration, including nucleoli, stress granules, Cajal bodies, and numerous additional bodies, regulated

82 cells involves trafficking of telomerase to Cajal bodies, and telomerase is thought to be recruited

83 nelles including nucleoli, nuclear speckles, Cajal bodies, as well as in the clusters of heterochroma

84 rference prevents TERC from associating with Cajal bodies, disrupts telomerase-telomere association,

85 body protein 1), that is notably enriched in Cajal bodies, nuclear sites of RNP processing that are i

86 Nuclear bodies including nucleoli, Cajal bodies, nuclear speckles, Polycomb bodies, and par

87 membraneless organelles, including nucleoli, Cajal bodies, P-bodies, and stress granules, exist as li

88 as nucleolar import of the ORF3 protein via Cajal bodies, relocalization of some fibrillarin from th

89 in TCAB1 disrupt telomerase localization to Cajal bodies, resulting in misdirection of telomerase RN

90 ellular condensates-including the nucleolus, Cajal bodies, stress granules and P-bodies-implying that

91 phatases interfered with SMN accumulation in Cajal bodies, suggesting impaired SMN complex function,

92 phase lags between various protein pairs in Cajal bodies, suggesting viscoelastic interactions betwe

93 ously found TOE1 to localize specifically in Cajal bodies, where telomerase RNP complex assembly take

94 Some RNAs transit Cajal bodies, while others must concentrate in Cajal bod

95 oding replication-dependent histone (RDH) at Cajal bodies.

96 spliceosomal snRNPs and localizes to nuclear Cajal bodies.

97 disrupting the recruitment of the protein to Cajal bodies.

98 hat facilitates trafficking of telomerase to Cajal bodies.

99 histone locus bodies) that are distinct from Cajal bodies.

100 of the cell cycle hTR is found primarily in Cajal bodies.

101 sm and in distinct nuclear structures called Cajal bodies.

102 uclear dicing bodies (D-bodies), differ from Cajal bodies.

103 supporting the idea that NF7 associates with Cajal bodies.

104 ls coincident with TCAB1 delocalization from Cajal bodies.

105 so recruits key spliceosomal components from Cajal bodies.

106 entrates in two subnuclear structures termed Cajal body (CB) and gems.

107 C/D small nucleolar RNAs (snoRNAs) and small Cajal body (CB) RNAs (scaRNAs) form ribonucleoprotein (R

108 We show here that one of them, the Cajal body (CB), can be formed de novo.

109 Because of their localization in the nuclear Cajal body (CB), these guide RNAs are known as small CB-

110 Small Cajal body (CB)-specific RNPs (scaRNPs) function in post

111 nthesis, snoRNAs transiently localize to the Cajal body (in plant and animal cells) or the homologous

112 increase more than those of SMN in the same Cajal body after dynamic force application.

113 STA1 signals are exclusively present in the Cajal body and overlap with AGO4 in most nuclei.

114 SMN complex was identified as a new Cajal body autoantigen recognized by sera from white pat

115 ind directly to tRF-GG, and are required for Cajal body biogenesis, positioning these proteins as str

116 the elimination of the telomerase holoenzyme Cajal body chaperone TCAB1 or the Cajal body scaffold pr

117 through direct binding of TERC and regulates Cajal body localization of the telomerase.

118 reen in human cells for factors required for Cajal body localization.

119 dies similar to Cajal bodies but lacking the Cajal body marker Atcoilin.

120 embly factor, survival motor neuron, and the Cajal body marker, coilin.

121 riments include increased hTR RNA levels and Cajal body numbers, and expression of SV40 large T antig

122 tify a holoenzyme subunit, TCAB1 (telomerase Cajal body protein 1), that is notably enriched in Cajal

123 Box C/D small nucleolar and Cajal body ribonucleoprotein particles (sno/scaRNPs) dir

124 H/ACA small nucleolar and Cajal body ribonucleoproteins (RNPs) function in site-sp

125 ing, only a subset copurifies telomerase and Cajal body ribonucleoproteins.

126 efficient approach to deplete snoRNA, small Cajal body RNA (scaRNA) and small nuclear RNA in human a

127 controls trafficking of telomerase and small Cajal body RNAs (scaRNAs).

128 established telomerase components, and small Cajal body RNAs that are involved in modifying splicing

129 holoenzyme Cajal body chaperone TCAB1 or the Cajal body scaffold protein Coilin.

130 e core, conserved regions 4 and 5, and small Cajal body specific RNA domains of human TR have emerged

131 of the exon 2b encoded domain that mediates Cajal body targeting and self-association.

132 is widely known as the protein marker of the Cajal body, a subnuclear domain important to the biogene

133 wo nuclear organelles, the nucleolus and the Cajal body, respond to stress.

134 In contrast, the telomerase holoenzyme Cajal body-associated protein, TCAB1, was released from

135 ncident with the histone locus body (HLB), a Cajal body-like nuclear structure associated with the hi

136 where it couples to Cajal bodies and induces Cajal body-nucleolar association.

137 A [snoRNA], small nuclear RNA [snRNA], small Cajal body-specific RNA [scaRNA], and transfer RNA [tRNA

138 Small nucleolar RNAs (snoRNAs) and small Cajal body-specific RNAs (scaRNAs) are non-coding RNAs w

139 eukaryotic box C/D small nucleolar (sno) or Cajal body-specific RNAs guide base pairing with target

140 eins (RNPs), small nucleolar RNPs, and small Cajal body-specific RNPs, is sufficient for the formatio

141 levels and a loss of U3 snoRNA signal in the Cajal body.

142 neurons were originally described by Ramon y Cajal, but have not been thoroughly studied.

143 e peptide (GLP-1), in deep short axon cells (Cajal cells) of the olfactory bulb and its neuromodulato

144 lfactory bulb neuron (deep short axon cells, Cajal cells) that could be capable of modifying mitral c

145 muscle cells (CSMCs), interstitial cells of Cajal distributed in the myenteric region (ICC-MY) and f

146 n his theory of functional polarity, Ramon y Cajal first identified the soma and dendrites as the pri

147 Santiago Ramon y Cajal had referred to neurons as the 'mysterious butterf

148 nt and often prescient hypotheses of Ramon y Cajal have proven foundational for modern neuroscience,

149 ored in 151 MS patients recruited at Ramon y Cajal Hospital in Madrid, Spain.

150 ingle-mutant mice, both interstitial cell of Cajal hyperplasia and mast cell hyperplasia were exacerb

151 ped gastric and colonic interstitial cell of Cajal hyperplasia as well as cecal GIST.

152 (GIST) are related to interstitial cells of Cajal (ICC) and often contain activating stem cell facto

153 lectrically coupled to interstitial cells of Cajal (ICC) and PDGFRalpha(+) cells.

154 h muscle cells (SMCs), interstitial cells of Cajal (ICC) and platelet-derived growth factor receptor

155 ialized cells known as interstitial cells of Cajal (ICC) are distributed in specific locations within

156 Interstitial cells of Cajal (ICC) are pacemaker cells that generate electrical

157 s to determine whether interstitial cells of Cajal (ICC) are present in the guinea pig extrahepatic b

158 Interstitial cells of Cajal (ICC) are putative pacemaker cells in the rabbit u

159 Interstitial cells of Cajal (ICC) are required for normal gastrointestinal mot

160 Interstitial cells of Cajal (ICC) are unique cells that generate electrical pa

161 nnels are expressed by interstitial cells of Cajal (ICC) but not by smooth muscle cells (SMCs).

162 Interstitial cells of Cajal (ICC) control intestinal smooth muscle contraction

163 istinct populations of interstitial cells of Cajal (ICC) exist within the tunica muscularis of the ga

164 Interstitial cells of Cajal (ICC) express c-kit; however, it is unknown whethe

165 Interstitial cells of Cajal (ICC) express the receptor tyrosine kinase, KIT, t

166 KEY POINTS: Interstitial cells of Cajal (ICC) from murine colonic muscles express genes en

167 Interstitial cells of Cajal (ICC) generate pacemaker activity (slow waves) in

168 Interstitial cells of Cajal (ICC) generate slow waves and transduce neurotrans

169 Interstitial cells of Cajal (ICC) generate slow waves.

170 Disruptions in interstitial cells of Cajal (ICC) have also been reported.

171 Interstitial cells of Cajal (ICC) have been identified in urinary bladder of s

172 Nitrergic nerves and interstitial cells of Cajal (ICC) have been implicated in the regulation of py

173 ns and distribution of interstitial cells of Cajal (ICC) in human gastric muscles.

174 phological features of interstitial cells of Cajal (ICC) in the gastrointestinal (GI) tract are descr

175 generally assumed that interstitial cells of Cajal (ICC) in the human gastrointestinal tract have sim

176 tegrity of networks of interstitial cells of Cajal (ICC) is essential to preserve orderly contractile

177 scle, enteric neurons, interstitial cells of Cajal (ICC) or other cellular components.

178 Interstitial cells of Cajal (ICC) provide important regulatory functions in th

179 Interstitial cells of Cajal (ICC) provide pacemaker activity and functional br

180 es has determined that interstitial cells of Cajal (ICC) serve as pacemaker cells, conduits for activ

181 about the function of interstitial cells of Cajal (ICC) since their discovery more than 100 years ag

182 aves (SWs) produced by interstitial cells of Cajal (ICC) underlie phasic contractions in other gastro

183 Interstitial cells of Cajal (ICC) were described more than 100 years ago by Ra

184 Interstitial cells of Cajal (ICC) were proposed as potential mediators in moto

185 h muscle cells (SMCs), interstitial cells of Cajal (ICC), and cells expressing platelet-derived growt

186 h muscle cells (SMCs), interstitial cells of Cajal (ICC), and cells expressing platelet-derived growt

187 th muscle cells (SMC), interstitial cells of Cajal (ICC), and PDGFRalpha(+) cells (fibroblast-like ce

188 beta for glia, Kit for interstitial cells of Cajal (ICC), CD45 and CD68 for immune cells, and smoothe

189 sion, enteric neurons, interstitial cells of Cajal (ICC), smooth muscle cells and electrical activity

190 elopment, although the interstitial cells of Cajal (ICC), the cells of origin of GIST, were normal.

191 number and function of interstitial cells of Cajal (ICC), the gastrointestinal pacemaker cells, under

192 ls, but present in the interstitial cells of Cajal (ICC), the pacemaker cells that control smooth mus

193 master regulator in the intestinal cells of Cajal (ICC), thought to be the cells of origin of GIST.

194 ointestinal tract, the interstitial cells of Cajal (ICC), where activation triggers ICC proliferation

195 ses leading to loss of interstitial cells of Cajal (ICC), which generate intestinal pacemaker activit

196 athy, and depletion of interstitial cells of Cajal (ICC), which may cause dysrhythmias and impaired n

197 actively propagated by interstitial cells of Cajal (ICC).

198 pressed exclusively in interstitial cells of Cajal (ICC).

199 pacemaker cells termed interstitial cells of Cajal (ICC).

200 Colonic intramuscular interstitial cells of Cajal (ICC-IM) are associated with cholinergic varicosit

201 Intramuscular interstitial cells of Cajal (ICC-IM) are closely associated with enteric motor

202 iated in intramuscular interstitial cells of Cajal (ICC-IM) by activation of Ca(2+) -activated Cl(-)

203 iated in intramuscular interstitial cells of Cajal (ICC-IM) by activation of Ca(2+) -activated Cl(-)

204 Colonic intramuscular interstitial cells of Cajal (ICC-IM) exhibit spontaneous Ca(2+) transients man

205 intramuscular class of interstitial cells of Cajal (ICC-IM).

206 Intramuscular interstitial cells of Cajal (ICC-IMs) and cholinesterases restrict ACh accessi

207 enteric plexus, called interstitial cells of Cajal (ICC-MY).

208 aker cells such as the interstitial cells of Cajal (ICCs) and atypical SMCs that control other tonic

209 antifying densities of interstitial cells of Cajal (ICCs) and mapping slow-wave abnormalities in pati

210 to investigate whether interstitial cells of Cajal (ICCs) at these borders generated distinct rhythms

211 lls, which include the interstitial cells of Cajal (ICCs) from which GISTs presumably originate, and

212 D & AIMS: Depletion of interstitial cells of Cajal (ICCs) is common in diabetic gastroparesis.

213 e stem cells (SCs) for interstitial cells of Cajal (ICCs), electrical pacemaker, and neuromodulator c

214 ate cells, such as the interstitial cells of Cajal (ICCs), might detect nitrergic signals to indirect

215 is highly expressed in interstitial cells of Cajal (ICCs)-the presumed cell of origin for GIST-as wel

216 bon monoxide (CO) from interstitial cells of Cajal (ICCs).

217 Interstitial cells of Cajal in the deep muscular plexus of the small intestine

218 Since the work of Ramon y Cajal in the late 19th and early 20th centuries, neurosc

219 een myenteric neurons, interstitial cells of Cajal in the myenteric region (ICC-MY) and smooth muscle

220 first description of 'interstitial cells of Cajal' in the mammalian gut in 1911, scientists have fou

221 The interstitial nucleus of Cajal (InC) controls eye position for vertical eye movem

222 nduction pattern in the interstitial cell of Cajal is responsible for the generation of the full spat

223 Since the work of Golgi and Cajal, light microscopy has remained a key tool for neur

224 y of research suggests that impaired bladder Cajal-like interstitial cells (ICCs) are a important com

225 m of KIT, expression of Interstitial Cell of Cajal-like markers, and release of various matrix metall

226 Setting: Hospital Universitario Ramon y Cajal, Madrid, Spain.

227 Starting with the work of Cajal more than 100 years ago, neuroscience has sought t

228 A century ago, Cajal noted striking similarities between the neural cir

229 d is not seen in glia, interstitial cells of Cajal, or smooth muscle.

230 Since the groundbreaking work of Ramon y Cajal over a century ago, defining the neural circuits u

231 raised by neuroanatomical studies of Ramon y Cajal over a century ago.

232 Ramon y Cajal proclaimed the neuron doctrine based on circuit fe

233 s, and specifically in interstitial cells of Cajal, provides a means of transmitter disposal after st

234 Cajal recognized that the elaborate shape of neurons is

235 ontrols spatial ordering of cortical layers, Cajal-Retzius (C-R) cells play a crucial role in cortica

236 Cajal-Retzius (CR) cells are a transient cell population

237 Cajal-Retzius (CR) cells are among the earliest born cor

238 pha with p73beta results in the depletion of Cajal-Retzius (CR) cells in embryonic stages, thus depri

239 est populations of neurons in the brain, the Cajal-Retzius (CR) cells in the neocortex, which are kno

240 Cajal-Retzius (CR) cells play a crucial role in the form

241 Cajal-Retzius (CR) cells play a key role in the formatio

242 ring the development of the cerebral cortex, Cajal-Retzius (CR) cells settle in the preplate and coor

243 Cajal-Retzius (CR) cells, the earliest-born neurons in t

244 Cajal-Retzius (CR) cells, the predominant source of reel

245 , a progenitor pool that first gives rise to Cajal-Retzius (CR) cells, which populate layer I of all

246 The generation of Cajal-Retzius (CR) neurons is restricted to discrete sit

247 Here, we investigated how early born Cajal-Retzius (CR) neurons, which regulate the assembly

248 We propose that this newly defined Cajal-Retzius cell-dependent microcircuit may regulate s

249 CXCL12, indicating the existence of a direct Cajal-Retzius cell-interneuron monosynaptic connection.

250 l primordium overexpand, while production of Cajal-Retzius cells and hippocampal neurons decreases, r

251 se depends on both the membrane potential of Cajal-Retzius cells and the kinetics of the received GAB

252 Cajal-Retzius cells are a class of neurons believed to p

253 xpression of functional glutamate receptors, Cajal-Retzius cells are integrated in the synaptic netwo

254 opment of earliest-born preplate neurons and Cajal-Retzius cells at the expense of progenitors.

255 n of the CXC chemokine receptor 4 (CXCR4) in Cajal-Retzius cells by CXC chemokine ligand 12 (CXCL12)

256 anscription factor Tbr2 is expressed in both Cajal-Retzius cells derived from the cortical hem that g

257 s in the main receptor for SDF1 (CXCR4) have Cajal-Retzius cells displaced to deeper cortical layers.

258 XCL12 and gp120 modulate the excitability of Cajal-Retzius cells in opposite directions.

259 resynaptic GABAergic interneurons contacting Cajal-Retzius cells is important to understand the micro

260 We analyzed the connections that Cajal-Retzius cells make and receive, and found that the

261 ow that GABAergic evoked synaptic input onto Cajal-Retzius cells may either increase their excitabili

262 rom hippocampal stratum lacunosum-moleculare Cajal-Retzius cells of the CXCR4-EGFP mouse.

263 have addressed these questions by activating Cajal-Retzius cells optogenetically in mouse hippocampal

264 Cajal-Retzius cells orchestrate the development of corti

265 entorhinal cortex-CA1 synapse, suggest that Cajal-Retzius cells produce a diffuse output that may im

266 , and pharmacological experiments shows that Cajal-Retzius cells receive GABAergic input from oriens

267 the neocortex and hippocampus has shown that Cajal-Retzius cells receive predominantly, if not exclus

268 r paired recording experiments indicate that Cajal-Retzius cells receive small-amplitude, kinetically

269 Furthermore, we show that the axons of Cajal-Retzius cells target specifically the stratum lacu

270 ee different types of forebrain neurons: the Cajal-Retzius cells that populate the surface of the tel

271 marginal zone dysplasia with displacement of Cajal-Retzius cells to deeper cortical layers.

272 The connectivity from presynaptic Cajal-Retzius cells to interneurons was strong enough to

273 ice Tbr2 is required for proper migration of Cajal-Retzius cells to the DG; and, in the absence of Tb

274 a dramatically reduces spontaneous firing in Cajal-Retzius cells via hyerpolarization, and that cessa

275 comparing the properties of CXCR4-expressing Cajal-Retzius cells vs. CXCR4-non-expressing interneuron

276 TX, and decreased when presynaptic firing in Cajal-Retzius cells was reduced by the chemokine CXCL12,

277 so expressed in neurons in layer I (presumed Cajal-Retzius cells), and white matter (interstitial) ne

278 horage of radial glial endfeet, mislocalized Cajal-Retzius cells, and neuronal overmigration.

279 ties in the brain surface basement membrane, Cajal-Retzius cells, and radial glia.

280 n the migration of forebrain neurons such as Cajal-Retzius cells, interneurons moving to the ventral

281 kinergic modulation of spontaneous firing of Cajal-Retzius cells, mediated by the chemokine (C-X-C mo

282 Here, we addressed this issue by focusing on Cajal-Retzius neurons (CRs), key players in cortical dev

283 ber, GDF5, which is produced by the adjacent Cajal-Retzius neurons and turns on before outgrowth of t

284 ne (HAR1F) that is expressed specifically in Cajal-Retzius neurons in the developing human neocortex

285 1F is co-expressed with reelin, a product of Cajal-Retzius neurons that is of fundamental importance

286 neurons (i.e., interneurons, neurogliaform, Cajal-Retzius neurons) resembled those observed in other

287 produces morphogens such as Wnt3a, generates Cajal-Retzius neurons, and is regulated by Lhx2.

288 he adjacent hippocampus instead of producing Cajal-Retzius neurons.

289 spinal cord is still debatable; both Ramon y Cajal's battering ram hypothesis and a boundary cap mode

290 Since Cajal's first drawings of Golgi stained neurons, generat

291 nal studies have provided strong support for Cajal's view.

292 The 100-y-old neuron doctrine from Ramon y Cajal states that neurons are individual cells, rejectin

293 restore the numbers of interstitial cells of Cajal that are reduced in the nNOS(-/-) colon.

294 nerated by specialized interstitial cells of Cajal that produce the patterns of contractions required

295 Since the days of Cajal, the CA1 pyramidal cell has arguably received more

296 Ever since the foundational work of Cajal, the field has made numerous discoveries as to how

297 ed to the Desensitization Program at Ramon y Cajal University Hospital (RCUH).

298 ed to the Desensitization Program at Ramon y Cajal University Hospital.

299 Interstitial cells of Cajal, which express the calcium-activated chloride chan

300 Interstitial cells of Cajal, which express the receptor tyrosine kinase Kit, a