ライフサイエンスコーパス: ChE

1 dings suggest that dual modulation of CA and ChE activities is a promising strategy for treating cogn

2 tent combined inhibition of human BACE-1 and ChEs, as well as good antioxidant and CNS-permeable prop

3 their dual activity on brain CA isoforms and ChEs (AChE and BChE).

4 ignificant in vitro anticholinesterase (anti-ChE) activity, the most potent compound (44) among them

5 Compound 44 showed significant in vivo anti-ChE and antioxidant activities.

6 Both ChE transcripts have the characteristics of H-type catal

7 Cholinesterase (ChE) enzymes terminate action of the neurotransmitter ac

8 nhydrase (CA) activators and cholinesterase (ChE) inhibitors to enhance cognitive functions.

9 hybrid molecules out of the cholinesterase (ChE) inhibitor tacrine and a benzimidazole-based human c

10 ntact cholinergic cells with cholinesterase (ChE) inhibitors.

11 Cholinesterases (ChE), use a Glu-His-Ser catalytic triad to enhance the n

12 anophosphate (OP)-inhibited cholinesterases (ChE) was synthesized and tested in vitro and in vivo.

13 es of oxime reactivators of cholinesterases (ChEs) that contain tertiary amine or imidazole protonata

14 e interaction of E2020 with cholinesterases (ChEs) with known sequence differences, was examined in m

15 Cholesteryl esters (ChE) showed a subtype-specific elevation only in the MGD

16 nd 19 were identified as effective dual FAAH/ChE inhibitors, with well-balanced nanomolar activities.

17 at resembles the acyl pocket of invertebrate ChE, while the acyl-binding site of ChE1 is novel.

18 n this study treatment with the long-lasting ChE inhibitor metrifonate facilitated acquisition and re

19 ed during both study periods using Test-mate ChE (Model 400).

20 ped an imaging probe that allows activity of ChE to be detected using MRI.

21 disparate pH dependences for reactivation of ChE and the general base-catalyzed oximolysis of acetylt

22 n states are involved in the reactivation of ChE conjugates and in conferring nucleophilic reactivity

23 The members of the catalytic triad of ChEs, the three pairs of cysteine residues involved in i

24 e of the severe side effects that can plague ChE inhibitors, supporting metrifonate as a possible tre

25 The compounds are potent ChE inhibitors, and for the most promising hybrids, the

26 , particularly of hCA II and VII, and strong ChE inhibition with subnanomolar to low nanomolar IC(50)

27 We suggest that ChEs achieve their remarkable catalytic power in ester h

28 ivery, ChERT labels regions of the gut where ChE expression is expected.

29 and periphery, colocalization of ChERT with ChE could be confirmed and visualized at higher resoluti