ライフサイエンスコーパス: Cope rearrangement

1 erconvert through a [3,3] sigmatropic shift (Cope rearrangement).

2 erived from a combined C-H activation/siloxy-Cope rearrangement.

3 dienes required for an anion-accelerated oxy-Cope rearrangement.

4 addition occurs by a tandem cyclopropanation/Cope rearrangement.

5 igmatropic shift of 1,5-hexadiene, i.e., the Cope rearrangement.

6 e negative correlation in AZ28-catalyzed oxy-Cope rearrangement.

7 , the [1,5]-H shift in Z-pentadiene, and the Cope rearrangement.

8 hapten, which accelerate a unimolecular oxy-Cope rearrangement.

9 a stepwise [6+4] cycloaddition followed by a Cope rearrangement.

10 fragment enabled by an aromatization-driven Cope rearrangement.

11 ion of chirality to the gamma-position via a Cope rearrangement.

12 on of these adducts is possible via a facile Cope rearrangement.

13 l FA imaging that relies on a FA-induced aza-Cope rearrangement.

14 tal and theoretical evidence for an aromatic Cope rearrangement.

15 thermodynamic driving force for the aromatic Cope rearrangement.

16 monium cations capable of undergoing the aza Cope rearrangement.

17 n-allylation, enol ether hydrolysis, and the Cope rearrangement.

18 reactant confers on 1 the lowest barrier to Cope rearrangement.

19 reported examples of fully concerted allenyl Cope rearrangements.

20 cyclopropanation-Cope and translactonization-Cope rearrangements.

21 the development of tandem translactonization-Cope rearrangements.

22 An intramolecular anionic oxy-Cope rearrangement (44 --> 46) serves as the key step in

23 lases through a three-step cascade involving Cope rearrangement, 6-exo-trig cyclization, and a final

24 a's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, a one-pot ozonolysis-reductive amina

25 ving an antibody AZ-28 that catalyses an oxy-Cope rearrangement, a pericyclic reaction that belongs t

26 hetic utility of the combined C-H activation/Cope rearrangement, achieved by dirhodium tetraprolinate

27 ies of substituted semibullvalenes and their Cope rearrangement activation barrier.

28 idered to occur by a tandem cyclopropanation/Cope rearrangement, although evidence is presented that

29 three-step sequence comprising a thermal oxy-Cope rearrangement, an iridium-catalyzed hydrogenation,

30 e by the sequential implementation of an oxy-Cope rearrangement and an intramolecular ene reaction, p

31 yrophosphate through a presumed biosynthetic Cope rearrangement and subsequent 6-exo-trig cyclization

32 ling by carbon in organic reactions, (6) the Cope rearrangement and the effect of substituents on it,

33 A diastereocontrolled (>30:1) anionic oxy-Cope rearrangement and the intramolecular rearrangement

34 e cyclopropanations, tandem cyclopropanation/Cope rearrangements and a combined C-H functionalization

35 scission, opening access to the interrupted Cope rearrangements and expanding the scope of this clas

36 ic oxidation, ketone allylation, anionic oxy-Cope rearrangement, and acid-promoted cyclization.

37 ns, Cope rearrangement, divinyl cyclopropane-Cope rearrangement, and C-C cleavage "cut-and-sew" react

38 E)-cyclodeca-1,3,7-triene that are stable to Cope rearrangement, and reactions should proceed at clos

39 d to a less stable [4+2] adduct via a facile Cope rearrangement, and the [4+2] adduct is converted in

40 a's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, and the Lewis acid-promoted cyclizat

41 nacol rearrangement, benzannulation, and oxy-Cope rearrangement are major pathways of transforming th

42 genic-beta-formyl amides in asymmetric 2-aza-Cope rearrangements are described.

43 and aborted pericyclic reactions, using the Cope rearrangement as a model process.

44 plished by using the combined C-H activation/Cope rearrangement as the key step and the previously sy

45 rgies, the activation free energy of the oxy-Cope rearrangement becomes larger in the mature antibody

46 The tandem cyclopropanation/Cope rearrangement between bicyclic dienes and siloxyvin

47 of regioselectively tunable conditions for a Cope rearrangement between C3 and C4 positions.

48 ization process, the combined C-H activation/Cope rearrangement, between methyl (E)-2-diazo-3-penteno

49 ese reactions was shown to occur by 2-oxonia-Cope rearrangements by way of a (Z)-oxocarbenium ion int

50 Oxonia-Cope rearrangements can be disfavored by destabilizing t

51 ap, we herein probe whether bullvalene Hardy-Cope rearrangements can be mechanically perturbed in bul

52 -assisted asymmetric anion-accelerated amino-Cope rearrangement cascades.

53 ium-catalyzed combined C-H functionalization/Cope rearrangement (CH/Cope) reaction discovered by the

54 achieved through C-H insertion combined with Cope rearrangement (CHCR) in the presence of dirhodium c

55 The combined C-H activation/Cope rearrangement (CHCR) is an effective C-H functional

56 g affinity and the catalytic rate of the oxy-Cope rearrangement compared to the germ line catalytic a

57 A rapid Cope rearrangement converts the [6+4] adduct into the ob

58 conjugative propargylation, 2) one-pot enyne Cope rearrangement/deconjugative propargylation, and 3)

59 yclohexenone followed by methylation and oxy-Cope rearrangement delivered enantiomerically enriched 2

60 on of a cyclic enone followed by anionic oxy-Cope rearrangement delivered the ketone as a mixture of

61 tegies featuring Diels-Alder cycloadditions, Cope rearrangement, divinyl cyclopropane-Cope rearrangem

62 However, the analogous base-promoted oxy-aza-Cope rearrangement does take place to form cis-hydroisoq

63 ic cages is inverted through strain-assisted Cope rearrangements, emulating the low-barrier configura

64 al cavity is capable of catalyzing the 3-aza-Cope rearrangement enantioselectively, with yields of 21

65 mation, [2,3]-sigmatropic rearrangement, oxy-Cope rearrangement, enol-keto tautomerization and finall

66 The oxy-anion Cope rearrangement followed by protonation of the enolat

67 icyclic spirolactams resulting from aromatic Cope rearrangements followed by ene reactions.

68 wt DMATS and FgaPT2) versus an indole C3-C4 "Cope" rearrangement followed by rearomatization (for mut

69 4-methylation results in the discovery of a Cope rearrangement for Meldrum's acid-containing substra

70 We expand further the use of Cope rearrangements for the synthesis of highly valuable

71 Reduction of the latter, followed by Cope rearrangement generates cycloheptadienylmethanols.

72 itial products can be induced to undergo oxy-Cope rearrangements giving 2,5-hexadienals (9).

73 etheno bridge in 3 makes the barrier for its Cope rearrangement higher than that for 4 and also contr

74 ect C-H insertion product undergoes a siloxy-Cope rearrangement in a stereoselective manner.

75 panantion and/or the combined C-H activation/Cope rearrangement in good overall yield and with good d

76 Since the discovery of the Cope rearrangement in the 1940s, no asymmetric variant o

77 e, including the first example of an aborted Cope rearrangement in the absence of a metal catalyst.

78 method favors the concerted mechanism of the Cope rearrangement involving an aromatic transition stat

79 barrier of approximately 6 kcal/mol for the Cope rearrangement is consistent with the stepwise mecha

80 The mechanism of the organocatalytic Cope rearrangement is elucidated through a combined comp

81 The Cope rearrangement is found to be stereospecific and can

82 e 30 to 32, the [3,3]-sigmatropic shift (aza-Cope rearrangement) is preferred over the Dimroth mechan

83 ding to (+)-occidentalol (3), and 28% to the Cope rearrangement leading to a close analogue of dictyo

84 A detailed examination of the use of aza-Cope rearrangement-Mannich cyclization sequences for ass

85 the synthesis utilizes a tandem cationic aza-Cope rearrangement/Mannich cyclization reaction for acce

86 Using a sequential base-promoted oxy-aza-Cope rearrangement/Mannich cyclization sequence, gram qu

87 The 2-oxonia Cope rearrangement may be a factor in the regioselectivi

88 The route begins with the tandem anionic oxy-Cope rearrangement/methylation/transannular ene cyclizat

89 Previous studies have shown that the allenyl Cope rearrangement of 1,2, 6-heptatriene (1) to 3-methyl

90 opropanation and the combined C-H activation/Cope rearrangement of 1,2-dihydronaphthalenes are methyl

91 reported previously, hydrazides catalyze the Cope rearrangement of 1,5-hexadiene-2-carboxaldehydes vi

92 ve been used to examine the mechanism of the Cope rearrangement of 1,5-hexadiene.

93 However, the relatively low barrier to the Cope rearrangement of 2 is largely due to the TS for thi

94 Oxy-Cope rearrangement of 8 followed by a secondary addition

95 tion at C-1, (ii) Wittig reaction, and (iii) Cope rearrangement of a 1,5-diene derivative, is reporte

96 Gold(I) catalysts effectively promote the Cope rearrangement of acyclic 1,5-dienes bearing a termi

97 lecular tetrahedron that catalyzes the 3-aza-Cope rearrangement of allyl enammonium cations.

98 s employed as a catalytic host for the 3-aza Cope rearrangement of allyl enammonium cations.

99 ons, but in the presence of acid, the azonia-Cope rearrangement of an allyl group and the true Dimrot

100 adien-3-ol, we have found that the gas-phase Cope rearrangement of both tertiary and secondary alkoxi

101 The Cope rearrangement of cyclo-biphenalenyl 9 is studied by

102 r is whether the mechanism of the degenerate Cope rearrangement of semibullvalene can be affected by

103 The degenerate Cope rearrangement of semibullvalene, a pericyclic react

104 atom tunneling is involved in the degenerate Cope rearrangement of semibullvalenes at cryogenic tempe

105 The low activation barrier to the Cope rearrangement of semibullvalenes has been attribute

106 state analogue (TSA) 1 and catalyzes the oxy-Cope rearrangement of substrate 2 to product 3.

107 tly, the conformationally restricted allenyl Cope rearrangement of syn-7-allenylnorbornene (7) has al

108 2) fragment subsequently mediates a stepwise Cope rearrangement of the doubly dearomatized intermedia

109 (pi)2 cycloadditions and, especially, rapid Cope rearrangement of the products, but, in many cases,

110 proceeds by a cyclopropanation followed by a Cope rearrangement of the resulting divinylcyclopropane.

111 tallo-Nazarov cyclization/1,6-enyne addition/Cope rearrangement of the substrate was found to selecti

112 The effects of fluorine substitution on the Cope rearrangements of 1,5-hexadiene and 2,2'-bis-methyl

113 relative barrier heights for the degenerate Cope rearrangements of semibullvalene (1), barbaralane (

114 /(6,6)CASSCF/6-31G level calculations on the Cope rearrangements of syn-5-ethenylbicyclo[2.1.0]pent-2

115 for the conformationally restricted allenyl Cope rearrangements of syn-5-propadienylbicylco[2.1.0]pe

116 [3,3]-Sigmatropic shifts (hetero-Cope rearrangements) of the corresponding allyl, proparg

117 e synthesis include a diastereoselective oxy-Cope rearrangement/oxidation sequence to install the C(1

118 lude a strategy-level diastereoselective oxy-Cope rearrangement/oxidation sequence, a Petasis-Ferrier

119 c limitations of an anionic asymmetric amino-Cope rearrangement platform.

120 acts as the 4pi component, and a subsequent Cope rearrangement produces the formal [6F + 4T] adduct.

121 nown for its anticancer activity, and of its Cope rearrangement product curzerene, was achieved by HP

122 ts of 3,3-dicyano-1,5-dienes to form reduced Cope rearrangement products.

123 The oxy-Cope rearrangement reaction in the antibody AZ28 is inve

124 hose formed from the tandem cyclopropanation/Cope rearrangement reaction of vinylcarbenes with dienes

125 y undergo the combined C-H functionalization/Cope rearrangement reaction via an s-cis/boat transition

126 Oxonia-Cope rearrangement resulted in the creation of the C18 c

127 The key step is a tandem Ireland Claisen/Cope rearrangement sequence, wherein the Ireland Claisen

128 ed our understanding of the cyclopropanation-Cope rearrangement sequence.

129 tope effect experiments demonstrate that the Cope rearrangement step, rather than iminium formation,

130 ) to have transition structures for boatlike Cope rearrangement that are equal to or lower in energy

131 n in turn drives a highly efficient silyloxy-Cope rearrangement that delivers the tetracyclic core of

132 barriers to cyclization, leads to a stepwise Cope rearrangement that is, nevertheless, stereoselectiv

133 Unlike the TS in the Cope rearrangement, the TS for a 1,5-hydrogen shift in 1

134 anomer of the 1,5-diene derivative underwent Cope rearrangement to afford 2-deoxy-2-C-glycal derivati

135 Then, we apply the cationic 2-aza-Cope rearrangement to deconstruct aminated diene polymer

136 intermediate which rapidly undergoes a 1-aza-Cope rearrangement to generate fused dihydroazepine deri

137 t relies on a diastereoselective anionic oxy-Cope rearrangement to set the relative configuration of

138 of the trans-eunicellane skeleton to undergo Cope rearrangement to yield inseparable atropisomers.

139 This convergent synthesis utilizes oxonia Cope rearrangements to prepare two key homoallylic alcoh

140 he first step of this sequence, cationic aza-Cope rearrangement, to form cis-hydroisoquinolinium ions

141 BDTS, HCDTS, and BTS and the chair and boat Cope rearrangement TSs (CCTS and BCTS) are discussed.

142 red ring, and that strain in turn drives the Cope rearrangement under unusually mild thermal conditio

143 talyst lowers the free-energy barrier of the Cope rearrangement via an associative transition state t

144 The mechanism of the amino-Cope rearrangement was explored with density functional

145 The oxonia-Cope rearrangement was shown to occur rapidly under typi

146 An oxonia-Cope rearrangement was used as an internal clock reactio

147 gements and a combined C-H functionalization/Cope rearrangement were achieved using Rh(2)(R-BTPCP)(4)

148 n a low-temperature anion-accelerated alkoxy-Cope rearrangement which proceeds by way of a strained c

149 have now expanded the scope of the reductive Cope rearrangement, which, via chemoselective reduction,

150 halene undergoes the combined C-H activation/Cope rearrangement while the other undergoes cyclopropan

151 They undergo fast, nearly degenerate Cope rearrangement with an activation barrier similar to

152 ily transformed into gamma-allyl enals via a Cope rearrangement without erosion of ee.

153 readily transformed into y-allyl enals via a Cope rearrangement without erosion of ee.