1 cella spp. (Brucella) and Coxiella burnetii (
Coxiella).
2 manipulated by Mycobacteria, Leishmania, and
Coxiella.
3 f B. anthracis (0.48%), Brucella (0.9%), and
Coxiella (
0.66%) in a total of 77 samples.
4 Coxiella actively regulates multiple events during infec
5 inal ASVs dataset consisted of seven genera:
Coxiella,
Anaplasma, Escherichia/Shigella, Ehrlichia, Bo
6 es were found to associate with ribosomes of
Coxiella and E. coli.
7 nov., related to the human pathogen
Coxiella and physically associated with the uncultured m
8 ystems found in the pathogens Legionella and
Coxiella and the conjugative apparatus of IncI plasmids.
9 teria of the genera Brucella, Rickettsia and
Coxiella,
and corona-, calici- and lyssaviruses and viru
10 ing those from the genus Bacillus, Brucella,
Coxiella,
and others, in bushmeat.
11 Anaplasma, Bartonella, Borrelia, Ehrlichia,
Coxiella,
and Phlebovirus pathogens.
12 Legionella and
Coxiella are intracellular pathogens that use the virule
13 Inhalation of low doses of
Coxiella bacteria can result in infection of the host al
14 Recombinant
Coxiella BCP (rBCP) was generated, and its DNA binding w
15 Taken as a whole, the results show that
Coxiella BCP binds DNA and likely serves to detoxify end
16 Functional expression of
Coxiella bcp was demonstrated by trans-complementation o
17 Coxiella BCP was initially identified as a potential DNA
18 acteria with classical peptidoglycan such as
Coxiella,
Buchnera and members of the Rickettsia genus.
19 is is a zoonotic bacterial disease caused by
Coxiella burnetii (C. burnetii) infection that occurs as
20 Q-fever is a flu-like illness caused by
Coxiella burnetii (Cb), a highly infectious intracellula
21 Coxiella burnetii (Cb), the causative agent of Q fever,
22 (B. anthracis), Brucella spp. (Brucella) and
Coxiella burnetii (Coxiella).
23 used by the obligate intracellular bacterium
Coxiella burnetii and can manifest as a flu-like illness
24 Coxiella burnetii and Chlamydia trachomatis are bacteria
25 For instance, mammalian pathogens such as
Coxiella burnetii and Francisella tularensis, as well as
26 s conserved in two other vacuolar pathogens,
Coxiella burnetii and Francisella tularensis.
27 Coxiella burnetii and Legionella pneumophila are evoluti
28 mber plasmids and encoded on plasmid QpH1 of
Coxiella burnetii and the F plasmid of Escherichia coli,
29 s of the primary adaptive immune response to
Coxiella burnetii are not well known.
30 Legionella pneumophila and
Coxiella burnetii are phylogenetically related intracell
31 Despite
Coxiella burnetii being an obligate intracellular bacter
32 o DNA-binding proteins have been detected in
Coxiella burnetii by southwestern (DNA-protein) blotting
33 Infection with
Coxiella burnetii can lead to acute and chronic Q fever.
34 Coxiella burnetii causes acute Q fever in humans and occ
35 Coxiella burnetii causes human Q fever, a zoonotic disea
36 enome of the obligate intracellular pathogen
Coxiella burnetii contains a large number of selfish gen
37 bited C. trachomatis but not T4SS-expressing
Coxiella burnetii development in a dose-dependent manner
38 The intracellular bacterial pathogen
Coxiella burnetii directs biogenesis of a parasitophorou
39 The intracellular bacterial pathogen
Coxiella burnetii directs biogenesis of a phagolysosome-
40 The obligate intracellular pathogen
Coxiella burnetii displays antiapoptotic activity which
41 The obligate intracellular pathogen
Coxiella burnetii encodes a deubiquitinase called EmcB t
42 The human pathogen
Coxiella burnetii encodes a type IV secretion system cal
43 Coxiella burnetii endocarditis is considered to be a lat
44 gh embyronated eggs, the Nine Mile strain of
Coxiella burnetii exhibits antigenic variation, a loss o
45 artonella quintana, Bartonella henselae, and
Coxiella burnetii from surgical heart valve tissue speci
46 2% each, Staphylococcus aureus in 13.6%, and
Coxiella burnetii in 10.6%.
47 , on replication of obligately intracellular
Coxiella burnetii in murine L-929 cells.
48 opting host Rho GTPases for establishment of
Coxiella burnetii infection and virulence in mammalian c
49 Protective immunity against
Coxiella burnetii infection is conferred by vaccination
50 bacteria in 3D within intact host cells in a
Coxiella burnetii infection model.
51 vaccine-induced protective immunity against
Coxiella burnetii infection, we compared the protective
52 antibody assay, weakly positive for phase II
Coxiella burnetii infection.
53 raphy for evidence of Bartonella species and
Coxiella burnetii infection.
54 Host control of
Coxiella burnetii infections is believed to be mediated
55 The obligate intracellular pathogen
Coxiella burnetii infects mammalian hosts without activa
56 Coxiella burnetii infects mononuclear phagocytes, where
57 A 5.8-kb chromosomal fragment isolated from
Coxiella burnetii initiates plasmid replication in Esche
58 Coxiella burnetii is a Gram-negative bacterium that caus
59 Coxiella burnetii is a gram-negative obligate intracellu
60 Coxiella burnetii is a Gram-negative, obligate intracell
61 Coxiella burnetii is a highly infectious bacterium that
62 Coxiella burnetii is a highly infectious obligate intrac
63 Coxiella burnetii is a widespread zoonotic bacterial pat
64 Coxiella burnetii is a zoonotic bacterial obligate intra
65 Coxiella burnetii is an intracellular bacterial pathogen
66 Coxiella burnetii is an intracellular bacterium that cau
67 Coxiella burnetii is an intracellular Gram-negative bact
68 Coxiella burnetii is an intracellular pathogen that repl
69 Coxiella burnetii is an obligate intracellular bacterial
70 Coxiella burnetii is an obligate intracellular bacterial
71 Coxiella burnetii is an obligate intracellular bacterial
72 Coxiella burnetii is an obligate intracellular bacterium
73 Coxiella burnetii is an obligate intracellular bacterium
74 Coxiella burnetii is an obligate intracellular bacterium
75 Coxiella burnetii is an obligate intracellular bacterium
76 Coxiella burnetii is an obligate intracellular bacterium
77 Coxiella burnetii is an obligate intracellular bacterium
78 Coxiella burnetii is an obligate intracellular Gram-nega
79 Coxiella burnetii is an obligate intracellular Gram-nega
80 Coxiella burnetii is an obligate intracellular pathogen
81 Coxiella burnetii is the bacterial agent of human Q feve
82 Coxiella burnetii is the causative agent of human Q feve
83 Coxiella burnetii is the causative agent of Q fever, a z
84 The intracellular bacterial pathogen
Coxiella burnetii is the etiological agent of the emergi
85 Coxiella burnetii is the Gram-negative bacterium respons
86 Coxiella burnetii load was high on-farm (2009), and lowe
87 Our recent study demonstrated that virulent
Coxiella burnetii Nine Mile phase I (NMI) is capable of
88 stand the mechanisms of formalin-inactivated
Coxiella burnetii phase I (PI) vaccine (PIV)-induced pro
89 line, he continued to have markedly elevated
Coxiella burnetii phase I antibody titers for 10 years a
90 on an extremely high antibody titer against
Coxiella burnetii phase I antigen.
91 The partition region qsopAB of the
Coxiella burnetii plasmid QpH1 was analyzed.
92 We present the first published case of
Coxiella burnetii prosthetic joint infection.
93 used by the intracellular bacterial pathogen
Coxiella burnetii Q fever presents with acute flu-like a
94 Coxiella burnetii replicates as distinct morphological f
95 The Q fever bacterium
Coxiella burnetii replicates inside host cells within a
96 Coxiella burnetii replicates within permissive host cell
97 We hypothesized that
Coxiella burnetii requires iron and employs an iron-regu
98 noculation with viable, but not inactivated,
Coxiella burnetii resulted in the increased expression o
99 relies on blood cultures and Bartonella and
Coxiella burnetii serology.
100 In addition to few
Coxiella burnetii serosurveys in vulnerable populations,
101 her odds of infection with Brucella spp. and
Coxiella burnetii than those of ages 35-80.
102 Coxiella burnetii undergoes a poorly defined development
103 Coxiella burnetii undergoes a poorly defined development
104 ellular pathogens Legionella pneumophila and
Coxiella burnetii use a type IV secretion system to deli
105 The Q fever agent
Coxiella burnetii uses a defect in organelle trafficking
106 Serodiagnosis for
Coxiella burnetii was performed for all patients.
107 The presence of
Coxiella burnetii was tested using immunofluorescence an
108 experimental infection with various doses of
Coxiella burnetii were tested by immunoblotting.
109 fever is a zoonosis caused by the bacterium
Coxiella burnetii which can manifest as infection of an
110 revious study demonstrated that treatment of
Coxiella burnetii with the phase I lipopolysaccharide (P
111 Q fever is caused by
Coxiella burnetii, a bacterium that persists in M2-polar
112 detect the obligate intracellular bacterium
Coxiella burnetii, a category B bioterrorism agent.
113 as Q fever, is a zoonotic disease caused by
Coxiella burnetii, a gram-negative bacterium that exerts
114 Coxiella burnetii, a Gram-negative obligate intracellula
115 Coxiella burnetii, a gram-negative obligate intracellula
116 Q fever is a zoonosis caused by
Coxiella burnetii, a unique bacterium that is widespread
117 in several Gram-negative species, including
Coxiella burnetii, Agrobacterium tumefaciens and Legione
118 in several Gram-negative species, including
Coxiella burnetii, Agrobacterium tumefaciens and Legione
119 and macrophage resistance to infection with
Coxiella burnetii, an obligate intracellular bacterium a
120 enic bacteria such as Enterococcus faecalis,
Coxiella burnetii, and Clostridium difficile.
121 ae, to an outer membrane protein (Com1) from
Coxiella burnetii, and to thioredoxin and thioredoxin-li
122 ation of the obligate intracellular pathogen
Coxiella burnetii, as it allows the completion of the le
123 ella pneumoniae, Legionella longbeachae, and
Coxiella burnetii, as well as the plant pathogen Ralston
124 pathogens Brucella spp., Toxoplasma gondii,
Coxiella burnetii, Francisella tularensis, and Neospora
125 racellular bacterial agent of human Q fever,
Coxiella burnetii, has a remarkable ability to persist i
126 As Q fever, caused by
Coxiella burnetii, is a major health challenge due to it
127 of Q fever, an infectious disease caused by
Coxiella burnetii, is associated with granuloma formatio
128 The causative agent of human Q fever,
Coxiella burnetii, is highly adapted to infect alveolar
129 8 bacteria (Bartonella spp., Brucella spp.,
Coxiella burnetii, Leptospira spp., Rickettsia spp., Sal
130 lular pathogens like Legionella pneumophila,
Coxiella burnetii, Listeria monocytogenes, and Chlamydia
131 The 1,995,275-bp genome of
Coxiella burnetii, Nine Mile phase I RSA493, a highly vi
132 oup I intron present in the 23S rRNA gene of
Coxiella burnetii, possesses a unique 3'-terminal adenin
133 fever, caused by the intracellular pathogen
Coxiella burnetii, relies mainly on serology and, in pre
134 t cell colonization by the Q fever pathogen,
Coxiella burnetii, requires translocation of effector pr
135 que to the bacteria Streptomyces griseus and
Coxiella burnetii, respectively.
136 Reactivity to the HGE agent and to either
Coxiella burnetii, Rickettsia rickettsii, or Rickettsia
137 ur selected pathogens of medical importance (
Coxiella burnetii, Rickettsia spp., Francisella tularens
138 The 23S rRNA gene of
Coxiella burnetii, the agent of Q fever in humans, conta
139 Growth of
Coxiella burnetii, the agent of Q fever, is strictly lim
140 It is of particular importance to
Coxiella burnetii, the biothreat pathogen that causes Q
141 Coxiella burnetii, the causative agent of human Q (Query
142 For over seven decades,
Coxiella burnetii, the causative agent of human Q fever,
143 s considered fundamental to the virulence of
Coxiella burnetii, the causative agent of human Q fever.
144 eral swine could contribute to the spread of
Coxiella burnetii, the causative agent of human Q fever.
145 rget candidate against the zoonotic pathogen
Coxiella burnetii, the causative agent of Q fever and a
146 Infections due to
Coxiella burnetii, the causative agent of Q fever, are u
147 Infection with
Coxiella burnetii, the causative agent of Q fever, can r
148 Coxiella burnetii, the causative agent of Q fever, estab
149 Coxiella burnetii, the causative agent of Q fever, is a
150 Coxiella burnetii, the causative agent of Q fever, is a
151 Coxiella burnetii, the causative agent of Q fever, is an
152 Coxiella burnetii, the causative agent of Q fever, is an
153 Coxiella burnetii, the causative agent of Q fever, secre
154 Genetically distinct isolates of
Coxiella burnetii, the cause of human Q fever, display d
155 Coxiella burnetii, the cause of human Q fever, is an aer
156 Successful macrophage colonization by
Coxiella burnetii, the cause of human Q fever, requires
157 In contrast to mycobacteria,
Coxiella burnetii, the etiologic agent of Q fever, inhab
158 Coxiella burnetii, the etiologic agent of Q fever, repli
159 Coxiella burnetii, the etiological agent of acute and ch
160 Coxiella burnetii, the etiological agent of human Q feve
161 Coxiella burnetii, the etiological agent of Q fever in h
162 Coxiella burnetii, the etiological agent of Q fever, has
163 Coxiella burnetii, the etiological agent of Q fever, is
164 Coxiella burnetii, the etiological agent of Q fever, is
165 Coxiella burnetii, the etiological agent of Q fever, is
166 Coxiella burnetii, the etiological agent of Q fever, is
167 -Higashi syndrome and in cells infected with
Coxiella burnetii, the rickettsial organism that causes
168 he intracellular bacterial agent of Q fever,
Coxiella burnetii, translocates effector proteins into i
169 HC-II in vaccine-mediated protection against
Coxiella burnetii, we evaluated the protective efficacy
170 iffers in male and female mice infected with
Coxiella burnetii, we hypothesized that circadian genes
171 Da outer membrane protein similar to Com1 of
Coxiella burnetii, which we designate as dsbA2.
172 South Limburg, the Netherlands, reported 220
Coxiella burnetii-related abortions in 450 pregnant goat
173 , a disease caused by the bacterial pathogen
Coxiella burnetii.
174 ave placentitis caused by a unique strain of
Coxiella burnetii.
175 used by the obligate intracellular bacterium
Coxiella burnetii.
176 group I introns in the sole 23S rRNA gene of
Coxiella burnetii.
177 canis, Ehrlichia ewingii, B. burgdorferi, or
Coxiella burnetii.
178 equence in a cloned IS1111a gene fragment of
Coxiella burnetii.
179 within 2 years after primary infection with
Coxiella burnetii.
180 Q fever is a worldwide zoonosis caused by
Coxiella burnetii.
181 Q fever is an infection caused by
Coxiella burnetii.
182 lla pneumophila, Legionella longbeachae, and
Coxiella burnetii.
183 Bacillus anthracis; Francisella tularensis;
Coxiella burnetii; and Ebola, Marburg, and Lassa fever v
184 Antibodies against
Coxiella burnetti, Francisella tularensis, and Rickettsi
185 chia chaffeensis, Rickettsia rickettsii, and
Coxiella burnetti, no significant cross-reactivity could
186 ion in the mean number of gold particles per
Coxiella call was observed at 12 h post-infection when c
187 this BSL2 model to investigate both host and
Coxiella components implicated in infection.
188 to CCVs for optimal homotypic fusion of the
Coxiella-
containing compartments.
189 ogen that directs the formation of an acidic
Coxiella-
containing vacuole (CCV) derived from the host
190 replicates inside host cells within a large
Coxiella-
containing vacuole (CCV) whose biogenesis relie
191 blish a large replication vacuole called the
Coxiella-
containing vacuole (CCV).
192 ia its Type 4 secretion system to generate a
Coxiella-
containing vacuole (CCV).
193 osome-derived intracellular niche termed the
Coxiella-
containing vacuole (CCV).
194 that replicates inside the lysosome-derived
Coxiella-
containing vacuole (CCV).
195 (T4SS) is critical for the formation of the
Coxiella-
containing vacuole and establishment of infecti
196 Dot/Icm system required acidification of the
Coxiella-
containing vacuole.
197 ytose virulent C. burnetii bacteria and form
Coxiella-
containing vacuoles (CCVs) and that C. burnetii
198 nslocated during infections and localizes to
Coxiella-
containing vacuoles (CCVs).
199 ative and epitope-tagged CBU0077 produced by
Coxiella displayed specific punctate localization at hos
200 In vivo,
Coxiella displays a tropism for mononuclear phagocytes w
201 urrently refractory to genetic manipulation,
Coxiella Dot/Icm substrates have been identified using b
202 We identified MceF (Mitochondrial
Coxiella effector protein F), a C. burnetii effector pro
203 the CCV and the intracellular replication of
Coxiella Effector proteins, translocated into the host c
204 nvestigated the role of CBU0077, a conserved
Coxiella effector that had previously been observed to l
205 that mitochondria are a bona fide target of
Coxiella effectors and MceA is a complex-forming effecto
206 Coxiella endosymbionts dominated the microbiome in all y
207 s will dramatically aid our ability to model
Coxiella-
host cell interactions.
208 ensable for the intracellular replication of
Coxiella in HeLa and THP-1 cells and did not appear to p
209 system and Mycobacterium, Sphingomonas, and
Coxiella in the full-scale system.
210 Although minimal detection of
Coxiella in TLR2(-/-) mouse spleens was observed, greate
211 The
Coxiella-
infected cell thus provides a unique model for
212 tor (TNF) superfamily homolog in Drosophila,
Coxiella-
infected flies exhibit reduced mortality from i
213 duals with past symptomatic and asymptomatic
Coxiella infection (convalescents) to promiscuous HLA cl
214 r at the mitochondrial outer membrane during
Coxiella infection.
215 e for this host GTPase-activating protein in
Coxiella infections.
216 The marked stability of the
Coxiella intron RNAs is presumably conferred by their as
217 netii and Francisella tularensis, as well as
Coxiella-
like and Francisella-like endosymbionts (CLEs a
218 ira halophila) that are distantly related to
Coxiella,
making it difficult to determine whether the i
219 a citrate buffer-based medium termed complex
Coxiella medium (CCM) that contains a mixture of three c
220 atients, 3 had nonpyogenic microorganism IE (
Coxiella or Candida).
221 f Mycobacterium, Toxoplasma, Leishmania, and
Coxiella pathogenesis, a detailed description of the mec
222 ly enhanced in the presence of a recombinant
Coxiella RNA DEAD-box helicase (CBU_0670) relative to th
223 ter understand the role that introns play in
Coxiella'
s biology, we determined the intrinsic stabilit
224 that the ribozymes have a negative effect on
Coxiella'
s growth.
225 oxify endogenous hydroperoxide byproducts of
Coxiella'
s metabolism during intracellular replication.
226 ns and a type IV secretion system closest to
Coxiella'
s that is expressed in Pacific Ocean metatransc
227 In this study, we investigated CstK (for
Coxiella Ser/Thr kinase), a protein kinase identified in
228 Coxiella sp., a likely endosymbiont, was found in both H
229 genetic diversity and virulence potential of
Coxiella species.
230 ated B2m KO and MHC-II KO mice produced less
Coxiella-
specific IgG than PIV-vaccinated WT mice.
231 hat the Drosophila TNF homolog Eiger and the
Coxiella T4SS are implicated in the pathogenesis of C. b
232 Protein substrates of the
Coxiella T4SS are predicted to facilitate the biogenesis
233 lator of the innate immune response allowing
Coxiella to behave as a stealth pathogen.
234 Engineering
Coxiella to express either MceA tagged with 3xFLAG or Mc
235 We also demonstrate that the
Coxiella type 4 secretion system (T4SS) is critical for
236 ntains elements homologous to the Legionella/
Coxiella Type IV secretion apparatus.
237 uolar-type (H+) ATPase (V-ATPase) within the
Coxiella vacuolar membrane was demonstrated by indirect
238 burnetii type 4B secretion system substrate
Coxiella vacuolar protein A (CvpA).
239 show that the C. burnetii secreted effector
Coxiella vacuolar protein B (CvpB) binds PI(3)P and phos
240 Four of the Dot/Icm substrates, termed
Coxiella vacuolar protein B (CvpB), CvpC, CvpD, and CvpE
241 valence rates of B. anthracis, Brucella, and
Coxiella were observed in wildebeest (56%), dik-dik (50%