ライフサイエンスコーパス: Creutzfeldt-Jakob disease

1 with human prions, such as those involved in Creutzfeldt-Jakob disease.

2 disease in humans were diagnosed as variant Creutzfeldt-Jakob disease.

3 e correct histological diagnosis of sporadic Creutzfeldt-Jakob disease.

4 e hitherto recognized phenotypic spectrum of Creutzfeldt-Jakob disease.

5 he most common human prion disease, sporadic Creutzfeldt-Jakob disease.

6 ng autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease.

7 ce of human-to-human transmission of variant Creutzfeldt-Jakob disease.

8 ted into the diagnostic criteria of sporadic Creutzfeldt-Jakob disease.

9 disease, nephrogenic diabetes insipidus, and Creutzfeldt-Jakob disease.

10 abnormalities that closely resemble sporadic Creutzfeldt-Jakob disease.

11 me have met diagnostic criteria for sporadic Creutzfeldt-Jakob disease.

12 iduals resembled those of classical sporadic Creutzfeldt-Jakob disease.

13 observed in sporadic, iatrogenic and variant Creutzfeldt-Jakob disease.

14 nine homozygote to both sporadic and variant Creutzfeldt-Jakob disease.

15 arkinson's disease, motor neuron disease and Creutzfeldt-Jakob disease.

16 can be acquired, as is the case for variant Creutzfeldt-Jakob disease.

17 ts both between and within cases of sporadic Creutzfeldt-Jakob disease.

18 in a unique series of nine cases of variant Creutzfeldt-Jakob disease.

19 us system (CNS) in five of six patients with Creutzfeldt-Jakob disease.

20 evere acute respiratory syndrome, or variant Creutzfeldt-Jakob disease.

21 cephalopathy (BSE) prions causes new variant Creutzfeldt-Jakob disease.

22 tance of some sheep to scrapie and humans to Creutzfeldt-Jakob disease.

23 patitis C virus, enterovirus 70, and variant Creutzfeldt-Jakob disease.

24 d either inherited prion disease or sporadic Creutzfeldt-Jakob disease.

25 y of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease.

26 symmetric pattern of involvement in sporadic Creutzfeldt-Jakob disease.

27 ld lead to a more virulent strain of variant Creutzfeldt-Jakob disease.

28 00% (95% CI, 90 to 100) for the detection of Creutzfeldt-Jakob disease.

29 vities in the total white matter in sporadic Creutzfeldt-Jakob disease.

30 rved in experimental, acquired, and sporadic Creutzfeldt-Jakob diseases.

31 ases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob diseases.

32 nt diagnoses were Alzheimer's disease (18%), Creutzfeldt-Jakob disease (12%) and inflammatory disorde

33 kob disease (15 of 15 with definite sporadic Creutzfeldt-Jakob disease, 13 of 14 with probable sporad

34 ings were positive in 30 of 31 patients with Creutzfeldt-Jakob disease (15 of 15 with definite sporad

35 f 14 patients with the E200K genetic form of Creutzfeldt-Jakob Disease, 20 healthy carriers of this m

36 he 77 patients who have developed iatrogenic Creutzfeldt-Jakob disease, 56 have been genotyped.

37 The French epidemics of iatrogenic Creutzfeldt-Jakob disease after growth hormone (GH) trea

38 Infection of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with

39 enotype individual can propagate the variant Creutzfeldt-Jakob disease agent and that the infectious

40 ssibility that the properties of the variant Creutzfeldt-Jakob disease agent could change after trans

41 s hypothalamic GT cells infected with the FU Creutzfeldt-Jakob disease agent, but not parallel mock c

42 tly demonstrated transmission of the variant Creutzfeldt-Jakob disease agent.

43 Sc) that accumulates in the brain in variant Creutzfeldt-Jakob disease also contains a minority type

44 m human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patien

45 c human neurodegenerative conditions variant Creutzfeldt-Jakob disease and Alzheimer's disease.

46 om donors who subsequently developed variant Creutzfeldt-Jakob disease and an asymptomatic red cell t

47 eases of humans and other animals, including Creutzfeldt-Jakob disease and bovine spongiform encephal

48 Familial Creutzfeldt-Jakob disease and cerebrotendinous xanthomat

49 able at low levels in some cases of sporadic Creutzfeldt-Jakob disease and conversely, that the form

50 iform encephalopathies (variant and sporadic Creutzfeldt-Jakob disease and genetic forms of prion dis

51 is related to various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Straussler-Schei

52 e only in the urine of patients with variant Creutzfeldt-Jakob disease and had the typical electropho

53 und in all of the major subtypes of sporadic Creutzfeldt-Jakob disease and in a case of iatrogenic Cr

54 samples obtained from patients with variant Creutzfeldt-Jakob disease and in none of the 224 urine s

55 m nasal brushings was accurate in diagnosing Creutzfeldt-Jakob disease and indicated substantial prio

56 Twenty-six patients with sporadic Creutzfeldt-Jakob disease and nine age- and gender-match

57 opagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases

58 re immediate candidates for the treatment of Creutzfeldt-Jakob disease and other prion diseases.

59 tes in the brains of patients suffering from Creutzfeldt-Jakob disease and related conditions, such a

60 n the pathogenesis of prion diseases such as Creutzfeldt-Jakob disease and scrapie.

61 patients with and patients without sporadic Creutzfeldt-Jakob disease and tested them using RT-QuIC,

62 the clinicopathological diversity evident in Creutzfeldt-Jakob disease and whether different prion pr

63 ogical conditions, including Alzheimer's and Creutzfeldt-Jakob diseases and type II diabetes.

64 kob disease, 13 of 14 with probable sporadic Creutzfeldt-Jakob disease, and 2 of 2 with inherited Cre

65 y this clinical syndrome is so distinct from Creutzfeldt-Jakob disease, and biomarkers of the early s

66 ion diseases, including sheep scrapie, human Creutzfeldt-Jakob disease, and cervid chronic wasting di

67 is centrally involved in the pathogenesis of Creutzfeldt-Jakob Disease, and its anatomical connection

68 tions can be detected early in the course of Creutzfeldt-Jakob Disease, and years before symptomatic

69 tions more common in the T/BG group included Creutzfeldt-Jakob disease, arbovirus, and Mycobacterium

70 Prion diseases such as Creutzfeldt-Jakob disease are possibly caused by the con

71 gregates derived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by i

72 Human prion diseases such as Creutzfeldt-Jakob disease are transmissible brain protei

73 spongiform encephalopathies, such as variant Creutzfeldt-Jakob disease, are believed to result from i

74 , in brain samples from humans with sporadic Creutzfeldt-Jakob disease, as well as in rodents with ex

75 dt-Jakob disease and in a case of iatrogenic Creutzfeldt-Jakob disease associated with growth hormone

76 and may be clinically mistaken for sporadic Creutzfeldt-Jakob disease because of a negative family h

77 ges that allowed early diagnosis of probable Creutzfeldt-Jakob disease before the characteristic clin

78 PrP(TSE)) when exposed to medium spiked with Creutzfeldt-Jakob disease brain homogenate, resulting in

79 -fold dilution of 10% (wt/vol) human variant Creutzfeldt-Jakob disease brain homogenate, with >3,800-

80 ned intensely for PrP(TSE) after exposure to Creutzfeldt-Jakob disease brain homogenate.

81 ldt-Jakob disease, and 2 of 2 with inherited Creutzfeldt-Jakob disease) but were negative in 43 of 43

82 ular system is a defining feature of variant Creutzfeldt-Jakob disease, but that the biochemical isof

83 cuses on transfusion-transmission of variant Creutzfeldt-Jakob disease by red cell preparations.

84 by this review, the transmission of variant Creutzfeldt-Jakob disease by transfusion has been confir

85 a precaution against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blo

86 al prion protein that characterizes sporadic Creutzfeldt-Jakob disease can be found in certain brain

87 Recent evidence that variant Creutzfeldt-Jakob disease can be transmitted by transfus

88 and findings were followed-up in six variant Creutzfeldt-Jakob disease cases with 9.4 T high-resoluti

89 n parameters from a UK cohort of 171 variant Creutzfeldt-Jakob disease cases.

90 In an effort to prevent new variant Creutzfeldt-Jakob disease, certain "specified offals," i

91 Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the

92 rP(Sc) aggregates extracted from 60 sporadic Creutzfeldt-Jakob disease (CJD) and 6 variant CJD brains

93 Creutzfeldt-Jakob disease (CJD) and autoimmune encephali

94 between the invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly pro

95 Prion protein (PrP) plays a central role in Creutzfeldt-Jakob Disease (CJD) and other transmissible

96 Human Creutzfeldt-Jakob disease (CJD) and similar neurodegener

97 typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distingui

98 ile cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and part

99 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are fatal, neuro-degener

100 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidl

101 ns from the brains of patients with sporadic Creutzfeldt-Jakob disease (CJD) bind to very low-density

102 uman brain extracts demonstrated that PrP in Creutzfeldt-Jakob disease (CJD) brains is cleaved by a c

103 lecular data from a large number of sporadic Creutzfeldt-Jakob disease (CJD) cases.

104 pendent reports have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G > A

105 rm encephalopathy (BSE) to humans as variant Creutzfeldt-Jakob disease (CJD) has affected over 100 in

106 Creutzfeldt-Jakob disease (CJD) has been accidentally tr

107 Although surgical transmission of Creutzfeldt-Jakob disease (CJD) has been demonstrated, t

108 Previous studies in Creutzfeldt-Jakob disease (CJD) have shown that myeloid

109 al, neurodegenerative diseases which include Creutzfeldt-Jakob disease (CJD) in humans and bovine spo

110 le neurodegenerative conditions that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spo

111 Creutzfeldt-Jakob disease (CJD) in humans has been shown

112 ssible neurodegenerative disorders including Creutzfeldt-Jakob disease (CJD) in humans, is the conver

113 ephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans.

114 cephalopathy (BSE) in cattle and PrP(CJD) in Creutzfeldt-Jakob disease (CJD) in humans.

115 Importance: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenera

116 Creutzfeldt-Jakob disease (CJD) is a neurodegenerative d

117 Creutzfeldt-Jakob disease (CJD) is a rare but invariably

118 Creutzfeldt-Jakob disease (CJD) is a rare progressive ne

119 Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly

120 Sporadic Creutzfeldt-Jakob disease (CJD) is the most prevalent ma

121 Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused

122 First, we successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, vari

123 cal heterogeneity, including patients with a Creutzfeldt-Jakob disease (CJD) phenotype.

124 pletely resistant to both kuru and classical Creutzfeldt-Jakob disease (CJD) prions (which are closel

125 s (PrPs) have shorter incubation periods for Creutzfeldt-Jakob disease (CJD) prions than mice express

126 More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of

127 disease, 19 with Parkinson's disease, 6 with Creutzfeldt-Jakob disease (CJD)).

128 ), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD

129 myoclonic jerks develop in individuals with Creutzfeldt-Jakob disease (CJD), an incurable brain diso

130 nd deer with those in subjects with sporadic Creutzfeldt-Jakob disease (CJD), as well as CJD-affected

131 ses numerous neurological diseases including Creutzfeldt-Jakob disease (CJD), but the aggregation mec

132 e most common human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are for

133 giform encephalopathy to people as a variant Creutzfeldt-Jakob disease (CJD), it becomes critical to

134 replication of the infectious agents causing Creutzfeldt-Jakob disease (CJD), scrapie, and bovine spo

135 Compared with a mouse model of transmissible Creutzfeldt-Jakob disease (CJD), the ataxia of Tg(A116V)

136 Creutzfeldt-Jakob disease (CJD), the most common human p

137 in different forms and molecular subtypes of Creutzfeldt-Jakob disease (CJD), we applied 3 different

138 His conditions were initially diagnosed as Creutzfeldt-Jakob disease (CJD).

139 en done aside from a small sample of variant Creutzfeldt-Jakob disease (CJD).

140 tic fluid, in a pregnant woman with sporadic Creutzfeldt-Jakob disease (CJD).

141 The most common human prion disease is Creutzfeldt-Jakob disease (CJD).

142 agnostic procedures were applied to diagnose Creutzfeldt-Jakob disease (CJD).

143 hat cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD).

144 cases of prion disease in humans, including Creutzfeldt-Jakob disease (CJD).

145 PrP(Sc) prion causes the rare human disorder Creutzfeldt-Jakob disease (CJD).

146 sceptible to prions from humans with variant Creutzfeldt-Jakob disease (CJD); on second passage in Tg

147 re classified as either familial or sporadic Creutzfeldt-Jakob disease (CJD); there was no case of va

148 ation associated with one of these diseases [Creutzfeldt-Jakob disease (CJD)] that was exactly analog

149 rophic lateral sclerosis (FTD/ALS, n = 252), Creutzfeldt-Jakob disease (CJD, n = 239), Parkinson's di

150 maging to study the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control su

151 samples obtained from patients with variant Creutzfeldt-Jakob disease contained minute quantities of

152 b disease (to date, 1,147 cases of confirmed Creutzfeldt-Jakob disease deaths in the United Kingdom s

153 sorders: fatal familial insomnia or familial Creutzfeldt-Jakob disease, depending upon the presence o

154 In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is

155 Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadav

156 Back-calculation analysis of the variant Creutzfeldt-Jakob disease epidemic in the United Kingdom

157 f growth hormone derived from a patient with Creutzfeldt-Jakob disease expressing prion protein valin

158 (E200K in humans), responsible for inherited Creutzfeldt-Jakob disease, finds that the mutation lower

159 urodegenerative disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinke

160 hether the strain characteristics of variant Creutzfeldt-Jakob disease had been modified by the host

161 The recent emergence of variant Creutzfeldt-Jakob disease has led to major public health

162 The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a po

163 fusion recipient, who did not die of variant Creutzfeldt-Jakob disease, has been identified with prio

164 Many cases of iatrogenic Creutzfeldt-Jakob disease have been caused by the use of

165 Three cases of variant Creutzfeldt-Jakob disease have been identified following

166 vious definite and probable cases of variant Creutzfeldt-Jakob disease have been methionine homozygot

167 ephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about th

168 long been used in the diagnosis of sporadic Creutzfeldt-Jakob disease; however, the characteristic w

169 in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little info

170 orts (FTLD, ALS, Alzheimer disease, sporadic Creutzfeldt-Jakob disease, Huntington disease-like syndr

171 In 2004, a subclinical case of variant Creutzfeldt-Jakob disease in a PRNP 129 methionine/valin

172 fatal neurodegenerative conditions including Creutzfeldt-Jakob disease in humans and scrapie and bovi

173 tal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, scrapie in sheep an

174 fatal neurodegenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in sheep an

175 ly occurring scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans.

176 sheep, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans.

177 Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a c

178 olfactory epithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients.

179 of 24 patients who have developed iatrogenic Creutzfeldt-Jakob disease in the UK since 2003.

180 ithin the cohort of patients with iatrogenic Creutzfeldt-Jakob disease in the UK suggests that there

181 for three individuals diagnosed with variant Creutzfeldt-Jakob disease in the USA and Canada.

182 ections with variant, sporadic, and familial Creutzfeldt-Jakob disease, in the presence of blood comp

183 d with other transmission studies in variant Creutzfeldt-Jakob disease, including those on the spleen

184 t were negative in 43 of 43 patients without Creutzfeldt-Jakob disease, indicating a sensitivity of 9

185 r significant numbers of subclinical variant Creutzfeldt-Jakob disease individuals in at least the Un

186 modification, the identification of variant Creutzfeldt-Jakob disease infection in a PRNP 129 methio

187 Sporadic Creutzfeldt-Jakob disease is considered primarily a dise

188 The incubation period of iatrogenic Creutzfeldt-Jakob disease is significantly different bet

189 Sporadic Creutzfeldt-Jakob disease is the most common of the huma

190 of humans and animals, one of which (variant Creutzfeldt-Jakob disease) is known to be a zoonotic for

191 novel acquired human prion disease, variant Creutzfeldt-Jakob disease, is thought to result from ora

192 including sporadic, variant, and iatrogenic Creutzfeldt-Jakob disease; kuru; inherited prion disease

193 exia and paresthesia, pure dementia GSS, and Creutzfeldt-Jakob disease-like GSS); GSS may be more com

194 t disease phenotypes, identified as sporadic Creutzfeldt-Jakob disease (M/M2 sCJD) and sporadic fatal

195 n the white matter of patients with sporadic Creutzfeldt-Jakob disease, mainly in the left hemisphere

196 in many neurodegenerative diseases including Creutzfeldt-Jakob disease, motor neuron disease and Alzh

197 59) and compare these with cases of sporadic Creutzfeldt-Jakob disease (n = 170) in the United Kingdo

198 PrP(Sc) from autopsy-proved cases of variant Creutzfeldt-Jakob disease (n = 59) and compare these wit

199 Its appearance can mimic sporadic Creutzfeldt-Jakob disease on MRI and should be considere

200 re was no evidence of any death from variant Creutzfeldt-Jakob disease or from conditions that could

201 an occur as an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the

202 rion protein disease with this feature after Creutzfeldt-Jakob disease, originally reported in 1920.

203 Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduc

204 In variant Creutzfeldt-Jakob disease, prion replication is thought

205 Evidence suggests that variant Creutzfeldt-Jakob disease prions circulate in body fluid

206 analysis also improved detection of sporadic Creutzfeldt-Jakob disease prions in human nasal brushing

207 it was ineffective in slowing propagation of Creutzfeldt-Jakob disease prions in transgenic mice.

208 nerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best ther

209 were concurrently less susceptible to human Creutzfeldt-Jakob disease prions.

210 Cumulatively, the data show that sporadic Creutzfeldt-Jakob disease PrP(Sc) is not a single confor

211 his case report from the Australian National Creutzfeldt-Jakob Disease Registry concerns a 61-year-ol

212 Conditions including Alzheimer's and Creutzfeldt-Jakob diseases represent, on this basis, pat

213 review of patients referred to the National Creutzfeldt-Jakob Disease Research & Surveillance Unit d

214 thought to confer susceptibility to sporadic Creutzfeldt-Jakob disease (rs1029273), all patients were

215 n clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to h

216 cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detect

217 Sporadic Creutzfeldt-Jakob disease (sCJD) comprises several subty

218 The sporadic form of Creutzfeldt-Jakob disease (sCJD) has been classified on

219 tal insomnia (sFI) and a subtype of sporadic Creutzfeldt-Jakob disease (sCJD) identified as sCJDMM2,

220 A case of sporadic Creutzfeldt-Jakob disease (sCJD) is described in a young

221 r 85% of human prion disease cases, sporadic Creutzfeldt-Jakob disease (sCJD) is the prevalent human

222 QuIC differentiated 94% of cases of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 from the sCJD MM2 p

223 studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype.

224 Sporadic Creutzfeldt-Jakob disease (sCJD) presents as a rapidly p

225 both hamster Sc237 prions and human sporadic Creutzfeldt-Jakob disease (sCJD) prions.

226 ort a detailed study of a cohort of sporadic Creutzfeldt-Jakob disease (sCJD) VV1-2 type-mixed cases

227 ding, the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

228 with the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

229 ct subtypes have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionin

230 brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(

231 Human sporadic Creutzfeldt-Jakob disease (sCJD), endemic sheep scrapie,

232 und PrP species present in control, sporadic Creutzfeldt-Jakob disease (sCJD), or variant CJD (vCJD)

233 the heart tissue of a patient with sporadic Creutzfeldt-Jakob Disease (sCJD), the most common form o

234 nic differences in individuals with sporadic Creutzfeldt-Jakob disease (sCJD).

235 ptible to prions from patients with sporadic Creutzfeldt-Jakob disease (sCJD).

236 ve disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD).

237 o neuronal antigens misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD).

238 rP species has been also claimed in sporadic Creutzfeldt-Jakob disease (sCJD).

239 as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic me

240 The variant Creutzfeldt-Jakob disease strain has to date been charac

241 Thus we have demonstrated variant Creutzfeldt-Jakob disease strain properties are not affe

242 fusivity within the white matter in sporadic Creutzfeldt-Jakob disease, suggesting possible primary i

243 s a single PrP(Sc) molecular type in variant Creutzfeldt-Jakob disease (termed type 2B), presumably r

244 PrP(Sc) was found in all 21 cases of variant Creutzfeldt-Jakob disease tested, irrespective of brain

245 A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)),

246 PrP 129M/V polymorphism protects people from Creutzfeldt-Jakob disease, the Sup35p polymorphisms were

247 As of mid-2016, 231 cases of variant Creutzfeldt-Jakob disease-the human form of a prion dise

248 The results show PrP(Sc) in variant Creutzfeldt-Jakob disease to be remarkably stereotyped.

249 , such as endotoxemia, sepsis, or iatrogenic Creutzfeldt-Jakob disease (to date, 1,147 cases of confi

250 xamined, and was also present in the variant Creutzfeldt-Jakob disease tonsil.

251 rent understanding of the risks of (variant) Creutzfeldt-Jakob disease transmission via dental practi

252 ere totally consistent with those of variant Creutzfeldt-Jakob disease transmitted to 129 methionine/

253 maining patients, dementia with Lewy bodies, Creutzfeldt-Jakob disease, vascular or unclassified deme

254 Variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform e

255 he fatal neurodegenerative condition variant Creutzfeldt-Jakob disease (vCJD) and, based on recent hu

256 dy indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient se

257 truments from, a deceased carrier of variant Creutzfeldt-Jakob disease (vCJD) can be followed up to q

258 as a result of the rising number of variant Creutzfeldt-Jakob disease (vCJD) cases.

259 Variant Creutzfeldt-Jakob disease (vCJD) differs from other huma

260 Variant Creutzfeldt-Jakob disease (vCJD) has a pathogenesis dist

261 Variant Creutzfeldt-Jakob disease (vCJD) has been recognized to

262 Person-to-person transmission of variant Creutzfeldt-Jakob disease (vCJD) has occurred through bl

263 Infections with variant Creutzfeldt-Jakob disease (vCJD) have almost exclusively

264 A small number of patients with variant Creutzfeldt-Jakob disease (vCJD) have been treated with

265 We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died f

266 ease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having gu

267 The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of

268 r relative human exposure levels and variant Creutzfeldt-Jakob disease (vCJD) incidence.

269 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

270 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

271 Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion

272 Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly

273 lity to, and clinical expression of, variant Creutzfeldt-Jakob disease (vCJD) is essential for future

274 Concerns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible

275 cal variation in the distribution of variant Creutzfeldt-Jakob disease (vCJD) might indicate the tran

276 mples, from prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD

277 spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully m

278 The transmission of variant Creutzfeldt-Jakob disease (vCJD) through blood transfusi

279 o be a reservoir for transmission of variant Creutzfeldt-Jakob disease (vCJD) to humans.

280 reasing concern since the reports of variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

281 Interindividual variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

282 timates for the risk of transmitting variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

283 fication of possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

284 Variant Creutzfeldt-Jakob disease (vCJD), a novel form of human

285 ) in urine of patients affected with variant Creutzfeldt-Jakob disease (vCJD), a prion disease typica

286 umans have since developed a variant form of Creutzfeldt-Jakob disease (vCJD), also mostly in the Uni

287 The onset of variant Creutzfeldt-Jakob disease (vCJD), and the unknown preval

288 athy (BSE) and its human equivalent, variant Creutzfeldt-Jakob disease (vCJD), are caused by the same

289 has been described in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bov

290 vine spongiform encephalopathy (BSE)/variant Creutzfeldt-Jakob disease (vCJD), Nipah virus, several v

291 in lymphoid tissues of patients with variant Creutzfeldt-Jakob disease (vCJD), sheep with natural scr

292 hy (BSE) prions, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).

293 sychological profile associated with variant Creutzfeldt-Jakob disease (vCJD).

294 detect clinically silent carriers of variant Creutzfeldt-Jakob disease (vCJD).

295 Transmission of variant Creutzfeldt-Jakob disease was observed from the MV blood

296 en PrP(Sc) types was maintained when variant Creutzfeldt-Jakob disease was transmitted to wild-type m

297 tected in the urine of patients with variant Creutzfeldt-Jakob disease, we used the protein misfoldin

298 en implicated both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular

299 sion and the appearance of a variant form of Creutzfeldt-Jakob disease, which has been linked to cons

300 Cases diagnosed as sporadic Creutzfeldt-Jakob disease with atypical neuropathology w