ライフサイエンスコーパス: Creutzfeldt

1 Creutzfeldt-Jakob disease (CJD) and autoimmune encephali

2 Creutzfeldt-Jakob disease (CJD) has been accidentally tr

3 Creutzfeldt-Jakob disease (CJD) in humans has been shown

4 Creutzfeldt-Jakob disease (CJD) is a neurodegenerative d

5 Creutzfeldt-Jakob disease (CJD) is a rare but invariably

6 Creutzfeldt-Jakob disease (CJD) is a rare progressive ne

7 Creutzfeldt-Jakob disease (CJD), the most common human p

8 nt diagnoses were Alzheimer's disease (18%), Creutzfeldt-Jakob disease (12%) and inflammatory disorde

9 rophic lateral sclerosis (FTD/ALS, n = 252), Creutzfeldt-Jakob disease (CJD, n = 239), Parkinson's di

10 cal heterogeneity, including patients with a Creutzfeldt-Jakob disease (CJD) phenotype.

11 rion protein disease with this feature after Creutzfeldt-Jakob disease, originally reported in 1920.

12 typical forms of Alzheimer disease (AD) and Creutzfeldt-Jakob disease (CJD) are clinically distingui

13 ephalopathy (BSE) and scrapie in animals and Creutzfeldt-Jakob disease (CJD) in humans.

14 ent disorders, ataxia, dystonia, chorea, and Creutzfeldt-Jakob with and Jewish.

15 arkinson's disease, motor neuron disease and Creutzfeldt-Jakob disease.

16 encephalopathy (BSE; "mad cow" disease) and Creutzfeldt-Jakob's disease, appears to be a beta-sheet-

17 sheep, bovine spongiform encephalopathy, and Creutzfeldt-Jakob disease in humans.

18 exia and paresthesia, pure dementia GSS, and Creutzfeldt-Jakob disease-like GSS); GSS may be more com

19 disease, nephrogenic diabetes insipidus, and Creutzfeldt-Jakob disease.

20 ey survive challenge with the human kuru and Creutzfeldt-Jakob agents as well as with scrapie agent i

21 ogical conditions, including Alzheimer's and Creutzfeldt-Jakob diseases and type II diabetes.

22 Conditions including Alzheimer's and Creutzfeldt-Jakob diseases represent, on this basis, pat

23 including dementias such as Alzheimer's and Creutzfeldt-Jakob's disease and other central nervous sy

24 as diverse as Alzheimer's, Parkinson's, and Creutzfeldt-Jakob disease share a common pathogenetic me

25 ases including Alzheimer's, Parkinson's, and Creutzfeldt-Jakob diseases.

26 s such as Alzheimer's (AD), Parkinson's, and Creutzfeldt-Jakob, and in animal diseases such as BSE.

27 nerative diseases, and arguably, scrapie and Creutzfeldt-Jakob disease prions represent the best ther

28 His conditions were initially diagnosed as Creutzfeldt-Jakob disease (CJD).

29 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are fatal, neuro-degener

30 Prion diseases such as Creutzfeldt-Jakob disease (CJD) are incurable and rapidl

31 hat cause neurodegenerative diseases such as Creutzfeldt-Jakob disease (CJD).

32 is related to various human diseases such as Creutzfeldt-Jakob disease and Gerstmann-Straussler-Schei

33 n the pathogenesis of prion diseases such as Creutzfeldt-Jakob disease and scrapie.

34 Prion diseases such as Creutzfeldt-Jakob disease are possibly caused by the con

35 Human prion diseases such as Creutzfeldt-Jakob disease are transmissible brain protei

36 en implicated both in prion diseases such as Creutzfeldt-Jakob disease, where its monomeric cellular

37 Infection of mice with an attenuated Creutzfeldt-Jakob disease agent (SY-CJD) interferes with

38 maining patients, dementia with Lewy bodies, Creutzfeldt-Jakob disease, vascular or unclassified deme

39 replication of the infectious agents causing Creutzfeldt-Jakob disease (CJD), scrapie, and bovine spo

40 pletely resistant to both kuru and classical Creutzfeldt-Jakob disease (CJD) prions (which are closel

41 b disease (to date, 1,147 cases of confirmed Creutzfeldt-Jakob disease deaths in the United Kingdom s

42 More than two hundred individuals developed Creutzfeldt-Jakob disease (CJD) worldwide as a result of

43 agnostic procedures were applied to diagnose Creutzfeldt-Jakob disease (CJD).

44 m nasal brushings was accurate in diagnosing Creutzfeldt-Jakob disease and indicated substantial prio

45 between the invariably lethal prion disease Creutzfeldt-Jakob disease (CJD) and nonprion rapidly pro

46 ation associated with one of these diseases [Creutzfeldt-Jakob disease (CJD)] that was exactly analog

47 PrP(Sc) prion causes the rare human disorder Creutzfeldt-Jakob disease (CJD).

48 Familial Creutzfeldt-Jakob disease and cerebrotendinous xanthomat

49 ections with variant, sporadic, and familial Creutzfeldt-Jakob disease, in the presence of blood comp

50 sorders: fatal familial insomnia or familial Creutzfeldt-Jakob disease, depending upon the presence o

51 ile cerebrospinal fluid (CSF) biomarkers for Creutzfeldt-Jakob disease (CJD) are established and part

52 A test that detects the specific marker for Creutzfeldt-Jakob disease, the prion protein (PrP(CJD)),

53 s (PrPs) have shorter incubation periods for Creutzfeldt-Jakob disease (CJD) prions than mice express

54 y this clinical syndrome is so distinct from Creutzfeldt-Jakob disease, and biomarkers of the early s

55 PrP 129M/V polymorphism protects people from Creutzfeldt-Jakob disease, the Sup35p polymorphisms were

56 tes in the brains of patients suffering from Creutzfeldt-Jakob disease and related conditions, such a

57 ), frontotemporal lobar degeneration (FTLD), Creutzfeldt-Jakob disease (CJD), Alzheimer's disease (AD

58 s hypothalamic GT cells infected with the FU Creutzfeldt-Jakob disease agent, but not parallel mock c

59 Human Creutzfeldt-Jakob disease (CJD) and similar neurodegener

60 ion diseases, including sheep scrapie, human Creutzfeldt-Jakob disease, and cervid chronic wasting di

61 were concurrently less susceptible to human Creutzfeldt-Jakob disease prions.

62 including sporadic, variant, and iatrogenic Creutzfeldt-Jakob disease; kuru; inherited prion disease

63 of 24 patients who have developed iatrogenic Creutzfeldt-Jakob disease in the UK since 2003.

64 he 77 patients who have developed iatrogenic Creutzfeldt-Jakob disease, 56 have been genotyped.

65 The French epidemics of iatrogenic Creutzfeldt-Jakob disease after growth hormone (GH) trea

66 dt-Jakob disease and in a case of iatrogenic Creutzfeldt-Jakob disease associated with growth hormone

67 Many cases of iatrogenic Creutzfeldt-Jakob disease have been caused by the use of

68 The incubation period of iatrogenic Creutzfeldt-Jakob disease is significantly different bet

69 , such as endotoxemia, sepsis, or iatrogenic Creutzfeldt-Jakob disease (to date, 1,147 cases of confi

70 Patients with iatrogenic Creutzfeldt-Jakob disease due to administration of cadav

71 ithin the cohort of patients with iatrogenic Creutzfeldt-Jakob disease in the UK suggests that there

72 in patients both with and without iatrogenic Creutzfeldt-Jakob disease; however, there is little info

73 Importance: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenera

74 pendent reports have claimed anticipation in Creutzfeldt-Jakob disease (CJD) caused by the c.598G > A

75 cephalopathy (BSE) in cattle and PrP(CJD) in Creutzfeldt-Jakob disease (CJD) in humans.

76 the clinicopathological diversity evident in Creutzfeldt-Jakob disease and whether different prion pr

77 with human prions, such as those involved in Creutzfeldt-Jakob disease.

78 uman brain extracts demonstrated that PrP in Creutzfeldt-Jakob disease (CJD) brains is cleaved by a c

79 Prion protein (PrP) plays a central role in Creutzfeldt-Jakob Disease (CJD) and other transmissible

80 Previous studies in Creutzfeldt-Jakob disease (CJD) have shown that myeloid

81 tal neurodegenerative disorders that include Creutzfeldt-Jakob disease in humans, scrapie in sheep an

82 al, neurodegenerative diseases which include Creutzfeldt-Jakob disease (CJD) in humans and bovine spo

83 tions more common in the T/BG group included Creutzfeldt-Jakob disease, arbovirus, and Mycobacterium

84 eases of humans and other animals, including Creutzfeldt-Jakob disease and bovine spongiform encephal

85 fatal neurodegenerative conditions including Creutzfeldt-Jakob disease in humans and scrapie and bovi

86 ses numerous neurological diseases including Creutzfeldt-Jakob disease (CJD), but the aggregation mec

87 in many neurodegenerative diseases including Creutzfeldt-Jakob disease, motor neuron disease and Alzh

88 fatal neurodegenerative diseases, including Creutzfeldt-Jakob disease in humans, scrapie in sheep an

89 ssible neurodegenerative disorders including Creutzfeldt-Jakob disease (CJD) in humans, is the conver

90 cases of prion disease in humans, including Creutzfeldt-Jakob disease (CJD).

91 (E200K in humans), responsible for inherited Creutzfeldt-Jakob disease, finds that the mutation lower

92 ldt-Jakob disease, and 2 of 2 with inherited Creutzfeldt-Jakob disease) but were negative in 43 of 43

93 The most common human prion disease is Creutzfeldt-Jakob disease (CJD).

94 hown to have pathology-proven sporadic Jakob-Creutzfeldt disease.

95 urodegenerative disorders that include Kuru, Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinke

96 his case report from the Australian National Creutzfeldt-Jakob Disease Registry concerns a 61-year-ol

97 review of patients referred to the National Creutzfeldt-Jakob Disease Research & Surveillance Unit d

98 opagation of prions, the causative agents of Creutzfeldt-Jakob disease and other human prion diseases

99 Heightened awareness of Creutzfeldt-Jakob disease (CJD) among physicians and the

100 tions can be detected early in the course of Creutzfeldt-Jakob Disease, and years before symptomatic

101 00% (95% CI, 90 to 100) for the detection of Creutzfeldt-Jakob disease.

102 Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly

103 The sporadic form of Creutzfeldt-Jakob disease (sCJD) has been classified on

104 umans have since developed a variant form of Creutzfeldt-Jakob disease (vCJD), also mostly in the Uni

105 f 14 patients with the E200K genetic form of Creutzfeldt-Jakob Disease, 20 healthy carriers of this m

106 sion and the appearance of a variant form of Creutzfeldt-Jakob disease, which has been linked to cons

107 evels of ERp57 increase mainly in neurons of Creutzfeldt-Jacob patients.

108 is centrally involved in the pathogenesis of Creutzfeldt-Jakob Disease, and its anatomical connection

109 it was ineffective in slowing propagation of Creutzfeldt-Jakob disease prions in transgenic mice.

110 e hitherto recognized phenotypic spectrum of Creutzfeldt-Jakob disease.

111 in different forms and molecular subtypes of Creutzfeldt-Jakob disease (CJD), we applied 3 different

112 Although surgical transmission of Creutzfeldt-Jakob disease (CJD) has been demonstrated, t

113 ges that allowed early diagnosis of probable Creutzfeldt-Jakob disease before the characteristic clin

114 s (NDs), including Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and Lou Gehrig's diseases, as well as

115 , diseases such as Alzheimer's, Parkinson's, Creutzfeldt-Jakob, and others display remarkable phenoty

116 Sporadic Creutzfeldt-Jakob disease (CJD) is the most prevalent ma

117 Sporadic Creutzfeldt-Jakob disease (sCJD) comprises several subty

118 Sporadic Creutzfeldt-Jakob disease (sCJD) presents as a rapidly p

119 Sporadic Creutzfeldt-Jakob disease is considered primarily a dise

120 Sporadic Creutzfeldt-Jakob disease is the most common of the huma

121 rP(Sc) aggregates extracted from 60 sporadic Creutzfeldt-Jakob disease (CJD) and 6 variant CJD brains

122 iform encephalopathies (variant and sporadic Creutzfeldt-Jakob disease and genetic forms of prion dis

123 rved in experimental, acquired, and sporadic Creutzfeldt-Jakob diseases.

124 o neuronal antigens misdiagnosed as sporadic Creutzfeldt-Jakob disease (sCJD).

125 Cases diagnosed as sporadic Creutzfeldt-Jakob disease with atypical neuropathology w

126 ding, the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

127 with the most common subtype being sporadic Creutzfeldt-Jakob disease (sCJD), a rapidly progressive

128 ve disorders, the most common being sporadic Creutzfeldt-Jakob disease (sCJD).

129 r 85% of human prion disease cases, sporadic Creutzfeldt-Jakob disease (sCJD) is the prevalent human

130 al prion protein that characterizes sporadic Creutzfeldt-Jakob disease can be found in certain brain

131 iduals resembled those of classical sporadic Creutzfeldt-Jakob disease.

132 und PrP species present in control, sporadic Creutzfeldt-Jakob disease (sCJD), or variant CJD (vCJD)

133 kob disease (15 of 15 with definite sporadic Creutzfeldt-Jakob disease, 13 of 14 with probable sporad

134 olfactory epithelium in diagnosing sporadic Creutzfeldt-Jakob disease in living patients.

135 orts (FTLD, ALS, Alzheimer disease, sporadic Creutzfeldt-Jakob disease, Huntington disease-like syndr

136 he most common human prion disease, sporadic Creutzfeldt-Jakob disease.

137 an occur as an idiopathic disorder (sporadic Creutzfeldt-Jakob disease) or can be acquired, as is the

138 e most common human prion disorder, sporadic Creutzfeldt-Jakob disease (CJD), in which prions are for

139 cerebrospinal fluid (CSF) tests for sporadic Creutzfeldt-Jakob disease (sCJD) are based on the detect

140 and may be clinically mistaken for sporadic Creutzfeldt-Jakob disease because of a negative family h

141 me have met diagnostic criteria for sporadic Creutzfeldt-Jakob disease.

142 ng autoimmune encephalopathies from sporadic Creutzfeldt-Jakob disease.

143 n clinic who were suspected to have sporadic Creutzfeldt-Jakob disease (sCJD) and yet were found to h

144 both hamster Sc237 prions and human sporadic Creutzfeldt-Jakob disease (sCJD) prions.

145 Human sporadic Creutzfeldt-Jakob disease (sCJD), endemic sheep scrapie,

146 ct subtypes have been identified in sporadic Creutzfeldt-Jakob disease (sCJD), based on the methionin

147 rP species has been also claimed in sporadic Creutzfeldt-Jakob disease (sCJD).

148 maging to study the white matter in sporadic Creutzfeldt-Jakob disease compared to healthy control su

149 In sporadic Creutzfeldt-Jakob disease, disease-associated PrP(Sc) is

150 fusivity within the white matter in sporadic Creutzfeldt-Jakob disease, suggesting possible primary i

151 symmetric pattern of involvement in sporadic Creutzfeldt-Jakob disease.

152 vities in the total white matter in sporadic Creutzfeldt-Jakob disease.

153 Its appearance can mimic sporadic Creutzfeldt-Jakob disease on MRI and should be considere

154 lecular data from a large number of sporadic Creutzfeldt-Jakob disease (CJD) cases.

155 59) and compare these with cases of sporadic Creutzfeldt-Jakob disease (n = 170) in the United Kingdo

156 tal insomnia (sFI) and a subtype of sporadic Creutzfeldt-Jakob disease (sCJD) identified as sCJDMM2,

157 QuIC differentiated 94% of cases of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 from the sCJD MM2 p

158 studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype.

159 ort a detailed study of a cohort of sporadic Creutzfeldt-Jakob disease (sCJD) VV1-2 type-mixed cases

160 brains of two patients, who died of sporadic Creutzfeldt-Jakob disease (sCJD), contained either sCJD(

161 able at low levels in some cases of sporadic Creutzfeldt-Jakob disease and conversely, that the form

162 und in all of the major subtypes of sporadic Creutzfeldt-Jakob disease and in a case of iatrogenic Cr

163 Definite diagnosis of sporadic Creutzfeldt-Jakob disease in living patients remains a c

164 analysis also improved detection of sporadic Creutzfeldt-Jakob disease prions in human nasal brushing

165 e correct histological diagnosis of sporadic Creutzfeldt-Jakob disease.

166 ted into the diagnostic criteria of sporadic Creutzfeldt-Jakob disease.

167 ts both between and within cases of sporadic Creutzfeldt-Jakob disease.

168 y of 80 to 90% for the diagnosis of sporadic Creutzfeldt-Jakob disease.

169 long been used in the diagnosis of sporadic Creutzfeldt-Jakob disease; however, the characteristic w

170 re classified as either familial or sporadic Creutzfeldt-Jakob disease (CJD); there was no case of va

171 d either inherited prion disease or sporadic Creutzfeldt-Jakob disease.

172 kob disease, 13 of 14 with probable sporadic Creutzfeldt-Jakob disease, and 2 of 2 with inherited Cre

173 abnormalities that closely resemble sporadic Creutzfeldt-Jakob disease.

174 Cumulatively, the data show that sporadic Creutzfeldt-Jakob disease PrP(Sc) is not a single confor

175 thought to confer susceptibility to sporadic Creutzfeldt-Jakob disease (rs1029273), all patients were

176 ns from the brains of patients with sporadic Creutzfeldt-Jakob disease (CJD) bind to very low-density

177 nd deer with those in subjects with sporadic Creutzfeldt-Jakob disease (CJD), as well as CJD-affected

178 tic fluid, in a pregnant woman with sporadic Creutzfeldt-Jakob disease (CJD).

179 the heart tissue of a patient with sporadic Creutzfeldt-Jakob Disease (sCJD), the most common form o

180 nic differences in individuals with sporadic Creutzfeldt-Jakob disease (sCJD).

181 ptible to prions from patients with sporadic Creutzfeldt-Jakob disease (sCJD).

182 Twenty-six patients with sporadic Creutzfeldt-Jakob disease and nine age- and gender-match

183 gregates derived from patients with sporadic Creutzfeldt-Jakob disease are taken up and degraded by i

184 , in brain samples from humans with sporadic Creutzfeldt-Jakob disease, as well as in rodents with ex

185 n the white matter of patients with sporadic Creutzfeldt-Jakob disease, mainly in the left hemisphere

186 patients with and patients without sporadic Creutzfeldt-Jakob disease and tested them using RT-QuIC,

187 ned intensely for PrP(TSE) after exposure to Creutzfeldt-Jakob disease brain homogenate.

188 tance of some sheep to scrapie and humans to Creutzfeldt-Jakob disease.

189 Compared with a mouse model of transmissible Creutzfeldt-Jakob disease (CJD), the ataxia of Tg(A116V)

190 Variant Creutzfeldt-Jakob disease (CJD) is thought to be caused

191 Variant Creutzfeldt-Jakob disease (vCJD) and bovine spongiform e

192 Variant Creutzfeldt-Jakob disease (vCJD) differs from other huma

193 Variant Creutzfeldt-Jakob disease (vCJD) has been recognized to

194 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

195 Variant Creutzfeldt-Jakob disease (vCJD) is a fatal neurodegener

196 Variant Creutzfeldt-Jakob disease (vCJD) is a novel human prion

197 Variant Creutzfeldt-Jakob disease (vCJD) is a unique and highly

198 Variant Creutzfeldt-Jakob disease (vCJD), a novel form of human

199 n parameters from a UK cohort of 171 variant Creutzfeldt-Jakob disease cases.

200 r relative human exposure levels and variant Creutzfeldt-Jakob disease (vCJD) incidence.

201 spongiform encephalopathy (BSE) and variant Creutzfeldt-Jakob disease (vCJD) prions are faithfully m

202 observed in sporadic, iatrogenic and variant Creutzfeldt-Jakob disease.

203 nine homozygote to both sporadic and variant Creutzfeldt-Jakob disease.

204 patitis C virus, enterovirus 70, and variant Creutzfeldt-Jakob disease.

205 rm encephalopathy (BSE) to humans as variant Creutzfeldt-Jakob disease (CJD) has affected over 100 in

206 spongiform encephalopathies, such as variant Creutzfeldt-Jakob disease, are believed to result from i

207 disease in humans were diagnosed as variant Creutzfeldt-Jakob disease.

208 dy indicates a prototype blood-based variant Creutzfeldt-Jakob disease (vCJD) assay has sufficient se

209 m human post-mortem samples, of both variant Creutzfeldt-Jakob disease and Alzheimer's disease patien

210 vine spongiform encephalopathy (BSE)/variant Creutzfeldt-Jakob disease (vCJD), Nipah virus, several v

211 ease reputed to be zoonotic, causing variant Creutzfeldt-Jakob disease (vCJD) in humans and having gu

212 he fatal neurodegenerative condition variant Creutzfeldt-Jakob disease (vCJD) and, based on recent hu

213 c human neurodegenerative conditions variant Creutzfeldt-Jakob disease and Alzheimer's disease.

214 Thus we have demonstrated variant Creutzfeldt-Jakob disease strain properties are not affe

215 om donors who subsequently developed variant Creutzfeldt-Jakob disease and an asymptomatic red cell t

216 novel acquired human prion disease, variant Creutzfeldt-Jakob disease, is thought to result from ora

217 can be acquired, as is the case for variant Creutzfeldt-Jakob disease.

218 re was no evidence of any death from variant Creutzfeldt-Jakob disease or from conditions that could

219 has been described in cases of human variant Creutzfeldt-Jakob disease (vCJD), experimental ovine bov

220 -fold dilution of 10% (wt/vol) human variant Creutzfeldt-Jakob disease brain homogenate, with >3,800-

221 s a single PrP(Sc) molecular type in variant Creutzfeldt-Jakob disease (termed type 2B), presumably r

222 Sc) that accumulates in the brain in variant Creutzfeldt-Jakob disease also contains a minority type

223 The results show PrP(Sc) in variant Creutzfeldt-Jakob disease to be remarkably stereotyped.

224 d with other transmission studies in variant Creutzfeldt-Jakob disease, including those on the spleen

225 In variant Creutzfeldt-Jakob disease, prion replication is thought

226 Interindividual variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

227 es the fatal prion disease named new variant Creutzfeldt-Jacob disease in humans.

228 The outbreak of new variant Creutzfeldt-Jakob disease has raised the specter of a po

229 cephalopathy (BSE) prions causes new variant Creutzfeldt-Jakob disease.

230 ephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about th

231 en done aside from a small sample of variant Creutzfeldt-Jakob disease (CJD).

232 PrP(Sc) from autopsy-proved cases of variant Creutzfeldt-Jakob disease (n = 59) and compare these wit

233 truments from, a deceased carrier of variant Creutzfeldt-Jakob disease (vCJD) can be followed up to q

234 as a result of the rising number of variant Creutzfeldt-Jakob disease (vCJD) cases.

235 Person-to-person transmission of variant Creutzfeldt-Jakob disease (vCJD) has occurred through bl

236 The development of variant Creutzfeldt-Jakob disease (vCJD) in three recipients of

237 The transmission of variant Creutzfeldt-Jakob disease (vCJD) through blood transfusi

238 reasing concern since the reports of variant Creutzfeldt-Jakob disease (vCJD) transmission through bl

239 fication of possible transmission of variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

240 The onset of variant Creutzfeldt-Jakob disease (vCJD), and the unknown preval

241 hy (BSE) prions, the causal agent of variant Creutzfeldt-Jakob disease (vCJD).

242 detect clinically silent carriers of variant Creutzfeldt-Jakob disease (vCJD).

243 cuses on transfusion-transmission of variant Creutzfeldt-Jakob disease by red cell preparations.

244 by this review, the transmission of variant Creutzfeldt-Jakob disease by transfusion has been confir

245 a precaution against transmission of variant Creutzfeldt-Jakob disease by transfusion of domestic blo

246 hether the strain characteristics of variant Creutzfeldt-Jakob disease had been modified by the host

247 The recent emergence of variant Creutzfeldt-Jakob disease has led to major public health

248 Three cases of variant Creutzfeldt-Jakob disease have been identified following

249 vious definite and probable cases of variant Creutzfeldt-Jakob disease have been methionine homozygot

250 In 2004, a subclinical case of variant Creutzfeldt-Jakob disease in a PRNP 129 methionine/valin

251 ly occurring scrapie in sheep and of variant Creutzfeldt-Jakob disease in humans.

252 modification, the identification of variant Creutzfeldt-Jakob disease infection in a PRNP 129 methio

253 Risk assessments for transmission of variant Creutzfeldt-Jakob disease predicted that leukocyte reduc

254 PrP(Sc) was found in all 21 cases of variant Creutzfeldt-Jakob disease tested, irrespective of brain

255 ere totally consistent with those of variant Creutzfeldt-Jakob disease transmitted to 129 methionine/

256 Transmission of variant Creutzfeldt-Jakob disease was observed from the MV blood

257 ular system is a defining feature of variant Creutzfeldt-Jakob disease, but that the biochemical isof

258 fusion recipient, who did not die of variant Creutzfeldt-Jakob disease, has been identified with prio

259 As of mid-2016, 231 cases of variant Creutzfeldt-Jakob disease-the human form of a prion dise

260 ce of human-to-human transmission of variant Creutzfeldt-Jakob disease.

261 in a unique series of nine cases of variant Creutzfeldt-Jakob disease.

262 ld lead to a more virulent strain of variant Creutzfeldt-Jakob disease.

263 ee cases of probable transmission of variant Creutzfeldt-Jakob infectivity by transfusion of red cell

264 lity to, and clinical expression of, variant Creutzfeldt-Jakob disease (vCJD) is essential for future

265 evere acute respiratory syndrome, or variant Creutzfeldt-Jakob disease.

266 mples, from prion-affected patients (variant Creutzfeldt-Jakob disease (vCJD) n = 20, iatrogenic CJD

267 We report a case of preclinical variant Creutzfeldt-Jakob disease (vCJD) in a patient who died f

268 and findings were followed-up in six variant Creutzfeldt-Jakob disease cases with 9.4 T high-resoluti

269 r significant numbers of subclinical variant Creutzfeldt-Jakob disease individuals in at least the Un

270 Concerns have been raised that variant Creutzfeldt-Jakob disease (vCJD) might be transmissible

271 Recent evidence that variant Creutzfeldt-Jakob disease can be transmitted by transfus

272 Evidence suggests that variant Creutzfeldt-Jakob disease prions circulate in body fluid

273 enotype individual can propagate the variant Creutzfeldt-Jakob disease agent and that the infectious

274 ssibility that the properties of the variant Creutzfeldt-Jakob disease agent could change after trans

275 tly demonstrated transmission of the variant Creutzfeldt-Jakob disease agent.

276 The variant Creutzfeldt-Jakob disease strain has to date been charac

277 xamined, and was also present in the variant Creutzfeldt-Jakob disease tonsil.

278 cell preparations are applicable to variant Creutzfeldt-Jakob in humans then a method for rendering

279 timates for the risk of transmitting variant Creutzfeldt-Jakob disease (vCJD) via blood transfusion h

280 en PrP(Sc) types was maintained when variant Creutzfeldt-Jakob disease was transmitted to wild-type m

281 of humans and animals, one of which (variant Creutzfeldt-Jakob disease) is known to be a zoonotic for

282 sceptible to prions from humans with variant Creutzfeldt-Jakob disease (CJD); on second passage in Tg

283 Infections with variant Creutzfeldt-Jakob disease (vCJD) have almost exclusively

284 A small number of patients with variant Creutzfeldt-Jakob disease (vCJD) have been treated with

285 ) in urine of patients affected with variant Creutzfeldt-Jakob disease (vCJD), a prion disease typica

286 sychological profile associated with variant Creutzfeldt-Jakob disease (vCJD).

287 e only in the urine of patients with variant Creutzfeldt-Jakob disease and had the typical electropho

288 samples obtained from patients with variant Creutzfeldt-Jakob disease and in none of the 224 urine s

289 samples obtained from patients with variant Creutzfeldt-Jakob disease contained minute quantities of

290 for three individuals diagnosed with variant Creutzfeldt-Jakob disease in the USA and Canada.

291 tected in the urine of patients with variant Creutzfeldt-Jakob disease, we used the protein misfoldin

292 rent understanding of the risks of (variant) Creutzfeldt-Jakob disease transmission via dental practi

293 First, we successfully propagated various Creutzfeldt-Jakob disease (CJD) isolates (sporadic, vari

294 disease, 19 with Parkinson's disease, 6 with Creutzfeldt-Jakob disease (CJD)).

295 myoclonic jerks develop in individuals with Creutzfeldt-Jakob disease (CJD), an incurable brain diso

296 f growth hormone derived from a patient with Creutzfeldt-Jakob disease expressing prion protein valin

297 ings were positive in 30 of 31 patients with Creutzfeldt-Jakob disease (15 of 15 with definite sporad

298 us system (CNS) in five of six patients with Creutzfeldt-Jakob disease.

299 PrP(TSE)) when exposed to medium spiked with Creutzfeldt-Jakob disease brain homogenate, resulting in

300 t were negative in 43 of 43 patients without Creutzfeldt-Jakob disease, indicating a sensitivity of 9