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1 by several species of the protozoan parasite Cryptosporidium.
2 three parasites: Plasmodium, Toxoplasma, and Cryptosporidium.
3 esulting in reduced in vivo efficacy against Cryptosporidium.
4 ot an important predictor of the presence of Cryptosporidium.
5 The PECs were infected with Cryptosporidium.
6 h quantitative polymerase chain reaction for Cryptosporidium.
7 find safe and effective drug candidates for Cryptosporidium.
8 optimized a rapid method to silence genes in Cryptosporidium.
9 hanisms that underlie protective immunity to Cryptosporidium.
10 duced invasion, proliferation, and egress of Cryptosporidium.
11 lic water systems (PWS) in the U.S. consider Cryptosporidium a microbial contaminant of surface water
12 alysis of any transcription factor family in Cryptosporidium, a basal-branching apicomplexan that is
14 ts/g (about 1 oocyst/g for a pica child) for Cryptosporidium, about 5 MPN/g (about 1 MPN/g for pica)
15 he findings of this study not only validated Cryptosporidium ACS (and related acyl-[acyl-carrier-prot
21 t of detection (LD), ca. 0.05 raw no's/L for Cryptosporidium and ca. 0.10 raw no's/L for Giardia.
22 alence is estimated to decline by 10.5% with Cryptosporidium and E. coli prevalence increasing by 9.9
25 emental Survey (ICR SS) required analysis of Cryptosporidium and Giardia in 10 L surface water sample
26 Data analysis illustrates key features of Cryptosporidium and Giardia in surface water: presence i
28 The data and analysis illustrate features of Cryptosporidium and Giardia occurrence in surface water
31 gG) and immunoglobulin A (IgA) antibodies to Cryptosporidium and rotavirus, and the lactulose to mann
32 e-phase synchronization was observed between Cryptosporidium and Shigella, Listeria, and Salmonella (
33 rks for Toxoplasma gondii, Neospora caninum, Cryptosporidium and Theileria species, and Babesia bovis
34 ty analysis of protozoan pathogens including Cryptosporidium and/or Giardia at the single (oo)cyst le
36 a include detectable parasitic (eg, Giardia, Cryptosporidium) and bacterial (eg, enteroaggregative Es
40 6, and 9 parasites per reaction for Giardia, Cryptosporidium, and Entamoeba parasites, respectively.
41 opies per reaction of the synthetic Giardia, Cryptosporidium, and Entamoeba targets, respectively (ro
44 We used reference pathogens Campylobacter, Cryptosporidium, and rotavirus as conservative risk prox
46 ites include those of the genera Plasmodium, Cryptosporidium, and Toxoplasma and those of the relativ
47 ion within 50 m and the sheep population for Cryptosporidium, and with the village illiteracy rate fo
49 e countries have confirmed the importance of cryptosporidium as a cause of diarrhoea and childhood ma
50 ldren have identified the protozoan parasite Cryptosporidium as the second most important diarrhoeal
54 (hERG) activity of the first-generation anti-Cryptosporidium BKIs triggered further testing for effic
55 ve nearly identical in vitro potency against Cryptosporidium but display divergent PK properties.
56 cable to the study wells, wells positive for Cryptosporidium by IFA would likely be required to add t
57 45) were sampled ( n = 964) and analyzed for Cryptosporidium by qPCR and immunofluorescence assay (IF
64 C. andersoni, C. ubiquitum, C. tyzzeri, and Cryptosporidium chipmunk genotype I were processed with
65 s sporozoites directly into the intestine, a Cryptosporidium clustered regularly interspaced short pa
67 etting is expected to marginally reduce pond Cryptosporidium contamination (16%) while increasing loc
68 ementing 3-log10 inactivation conditions for Cryptosporidium (CT value = 15300 mg.min/L) to remediate
70 ance-based device is able to get insights on Cryptosporidium development on a cell culture and to qua
72 ectively for the isolation and enrichment of Cryptosporidium DNA from fecal specimens for whole-genom
74 ults indicate that SUB1 is a key mediator of Cryptosporidium egress and suggest that interruption of
76 rhoea were due to four pathogens: rotavirus, Cryptosporidium, enterotoxigenic Escherichia coli produc
77 ova/parasite (O&P) examinations, and Giardia/Cryptosporidium enzyme immunoassay screens (GC-EIA) perf
80 sensor to detect different concentrations of Cryptosporidium, for which it is shown that the sample d
81 l method provides a novel means of silencing Cryptosporidium genes to study their role in host-parasi
83 ing sequence data covering 94.5% to 99.7% of Cryptosporidium genomes, with mostly minor contamination
84 ocedures for the isolation and enrichment of Cryptosporidium genomic DNA from fecal specimens and ver
86 lla/enteroinvasive E. coli (EIEC), protozoa (Cryptosporidium, Giardia lamblia, and Entamoeba histolyt
87 ncrease in immunoglobulin G directed against Cryptosporidium gp15 and/or Cp23 antigens between consec
88 elopment for neglected tropical diseases for Cryptosporidium growth inhibitors identifies the 6-carbo
93 of compounds inhibit CpKRS and C. parvum and Cryptosporidium hominis in culture, and our lead compoun
94 eba histolytica, Cryptosporidium parvum, and Cryptosporidium hominis Similarly, these species cause t
95 obiotic piglets experimentally infected with Cryptosporidium hominis, the species responsible for >75
98 because the molecular mechanisms underlying Cryptosporidium-host cell interactions are poorly unders
100 6; 1.6-4.1) in infants aged 0-11 months, and Cryptosporidium (HR 2.3; 1.3-4.3) in toddlers aged 12-23
101 ological experiments led us to conclude that Cryptosporidium imports purine nucleotides from the host
102 g more than 10,000 population to analyze for Cryptosporidium in at least 24 consecutive monthly sampl
103 native to hyperchlorination for inactivating Cryptosporidium in chlorinated recreational water venues
104 xide (ClO2) to achieve 2-log inactivation of Cryptosporidium in drinking water has been documented.
106 le of predicting the presence of Giardia and Cryptosporidium in fresh surface waters in the Chicago a
107 he prediction of the presence of Giardia and Cryptosporidium in our location and were closely aligned
112 andidate for treatment of diarrhea caused by Cryptosporidium in young children in the resource-limite
113 denovirus (in 29.1% and 2.7%, respectively), Cryptosporidium (in 27.8% and 8.2%, respectively), heat-
119 th no apparent toxicity when administered to Cryptosporidium-infected interleukin 12 knockout mice at
121 -to-person transmission is a major source of Cryptosporidium infection for young children living in t
123 KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immuno
125 Recent studies have illustrated the burden Cryptosporidium infection places on the lives of malnour
127 r, end-stage liver disease caused by chronic Cryptosporidium infection required liver transplantation
129 odel system capable of supporting continuous Cryptosporidium infection will be a useful tool for the
130 ct in vivo efficacy with a neonatal model of Cryptosporidium infection, these concentrations in the l
131 Despite the severity and global burden of Cryptosporidium infection, treatments are less than opti
132 ultiple in vitro models and a mouse model of Cryptosporidium infection, we characterized the effect o
140 uffering from recurrent bacterial, viral and Cryptosporidium infections, and identify a biallelic mut
155 Understanding the environmental pathways of Cryptosporidium is essential for effective management of
158 ld-killer and famously recalcitrant parasite Cryptosporidium is the latest organism to yield to the m
160 f mammals, and the CDPK1 of the apicomplexan Cryptosporidium lack side chains that typically block a
161 ing of parasite energy metabolism given that Cryptosporidium lacks oxidative phosphorylation and glyc
162 rehensive view of gene regulation during the Cryptosporidium life cycle will require the analysis of
165 e literature, the hypothesis is offered that Cryptosporidium may be found in surface water anywhere w
167 e, discrimination of Cryptosporidium parvum, Cryptosporidium muris and Giardia lamblia, with over 92%
172 hole, the data describe a spectrum of median Cryptosporidium occurrence in surface waters of the U.S.
175 levels of helminth eggs, Giardia cysts, and Cryptosporidium oocysts, but the UASB reactor system dis
176 ignificantly delays chlorine inactivation of Cryptosporidium oocysts, emphasizing the need for additi
178 fectious disease model to the 1993 Milwaukee Cryptosporidium outbreak, we demonstrate that environmen
179 emerged as a therapeutic target for treating Cryptosporidium parasites because it catalyzes a critica
182 processes driving the complex life cycle of Cryptosporidium parasites, we analyzed the transcriptome
184 chemical features and inhibitory kinetics of Cryptosporidium parvum ACSs using recombinant proteins.
187 effects of silver salt and nanoparticles on Cryptosporidium parvum and the removal of C. parvum by p
190 sly, we identified and characterized a novel Cryptosporidium parvum C-type lectin domain-containing m
194 ition, the inhibitory potential of two known Cryptosporidium parvum IMPDH inhibitors was examined for
196 The half maximal effective concentration for Cryptosporidium parvum in HCT-8 cells was determined to
198 effect of short-term protein malnutrition on Cryptosporidium parvum infection in a murine model by ex
199 erstanding the protective immune response to Cryptosporidium parvum infection is of critical importan
202 reviously) to support long-term infection by Cryptosporidium parvum Infection was assessed by immunof
207 surface charge heterogeneity on transport of Cryptosporidium parvum oocyst and carboxylate microspher
208 from pathogens such as Escherichia coli and Cryptosporidium parvum oocysts account for most of the c
210 Protein-deficient mice were infected with Cryptosporidium parvum oocysts for 6-13 days and compare
211 e and detect both Escherichia coli cells and Cryptosporidium parvum oocysts that have been embedded i
212 riments was performed with freshly harvested Cryptosporidium parvum oocysts to evaluate the effects o
213 human intestinal epithelial cells (HCT-8) by Cryptosporidium parvum resulted in a rapid induction of
215 ge of newly available molecular genetics for Cryptosporidium parvum to investigate nucleotide biosynt
217 y Giardia duodenalis, Entamoeba histolytica, Cryptosporidium parvum, and Cryptosporidium hominis Simi
223 eight enteropathogens (Giardia intestinalis, Cryptosporidium parvum, Entamoeba histolytica, Salmonell
224 idiosis, caused by the apicomplexan parasite Cryptosporidium parvum, is a diarrheal disease that has
228 eight wells (40%) and 107 samples (11%) were Cryptosporidium-positive by qPCR, and of these samples 6
231 tic infection in immunocompromised patients, Cryptosporidium research has lagged due to a lack of fac
234 ns parasitize within the host cell cytosols, Cryptosporidium resides on top of host cells, but it is
236 RBF on consumer health burdens for Giardia, Cryptosporidium, rotavirus, norovirus, and adenovirus in
240 ith the human enzyme Argonaute 2 (hAgo2) and Cryptosporidium single-stranded RNA (ssRNA), we induced
242 nd during diarrheal episodes were tested for Cryptosporidium species by polymerase chain reaction (PC
243 pisodes, and were tested for the presence of Cryptosporidium species by polymerase chain reaction.
244 nucleic acid test to detect the presence of Cryptosporidium species in DNA extracted from stool samp
245 rs, testing positive for either rotavirus or Cryptosporidium species in stool (coinfections were excl
246 the prevention of Entamoeba histolytica and Cryptosporidium species infection in children living in
248 ) is widely used to study gene function, but Cryptosporidium species lack the enzymes necessary to pr
249 parasiticidal, and potently inhibits the two Cryptosporidium species most relevant to human health, C
250 wing this strategy, 20 WGA products from six Cryptosporidium species or genotypes with low (mostly <1
252 poridium hominis (73.3%) was the predominant Cryptosporidium species, and there was no species-specif
254 groups of pathogens: Campylobacter species, Cryptosporidium species, Shiga toxin-producing Escherich
256 lasma immunoglobulin G, directed against the Cryptosporidium sporozoite-expressed antigen Cp23 at 12
258 %, 0.4-6.3), astrovirus (2.7%, 2.2-3.1), and Cryptosporidium spp (2.0%, 1.3-2.6) exhibited the highes
261 enic E coli producing heat-stable toxin, and Cryptosporidium spp might substantially reduce the diarr
262 ths), and 0.5 versus 0.2 (24-59 months); for Cryptosporidium spp was 3.6 versus 2.3 (0-11 months), 4.
264 la spp (non-dysentery cases), Aeromonas spp, Cryptosporidium spp, and Entamoeba histolytica increased
265 ects but does not differentiate Giardia spp, Cryptosporidium spp, and Entamoeba histolytica, the Tri-
266 Campylobacter jejuni and Campylobacter coli, Cryptosporidium spp, enteropathogenic Escherichia coli,
267 cases of MSD and LSD were due to rotavirus, Cryptosporidium spp, enterotoxigenic Escherichia coli en
269 o reuse simulation results are compared to a Cryptosporidium spp. database collected for the Long Ter
271 l GloWPa-Crypto L1 calculates a total global Cryptosporidium spp. load from livestock manure of 3.2 x
272 In this paper we aim to quantify livestock Cryptosporidium spp. loads to land on a global scale usi
273 sinia enterocolitica, Entamoeba histolytica, Cryptosporidium spp., and E. coli O157:H7; 95% for Giard
274 dium difficile), parasites (Giardia lamblia, Cryptosporidium spp., and Entamoeba histolytica), and vi
276 O157), Shigella spp./enteroinvasive E. coli, Cryptosporidium spp., Cyclospora cayetanensis, Entamoeba
277 ped countries, including Giardia lamblia and Cryptosporidium spp., using technologies that, if expand
278 lia (syn. G. intestinalis/G. duodenalis) and Cryptosporidium spp., using technologies that, if expand
281 introgression between the four anthroponotic Cryptosporidium subtypes and species included in this st
283 icomplexan intestinal parasites of the genus Cryptosporidium take a major toll on human and animal he
285 logical studies found the protozoan parasite Cryptosporidium to be a leading cause of paediatric diar
287 Here, we genetically engineered strains of Cryptosporidium to make life cycle progression and paras
288 n parasites, such as Plasmodium, Toxoplasma, Cryptosporidium, trypanosomes, and Leishmania, are a maj
289 ive pathogens (rotavirus, Shigella, ST-ETEC, Cryptosporidium, typical enteropathogenic E coli) can su
291 s and genotypes can infect humans, including Cryptosporidium viatorum, which, to date, has only been
292 ctions were mainly asymptomatic (693 [66%]), Cryptosporidium was identified in 9.4% of diarrheal epis
294 In the required sample volumes of 10 L no Cryptosporidium were found in 86% of samples and no Giar
296 poridium were found in 93% of samples and no Cryptosporidium were found in any samples analyzed from
297 tions representing every region of the U.S., Cryptosporidium were found in sufficient numbers of samp
298 arasites such as Plasmodium, Toxoplasma, and Cryptosporidium, which are causing severe health and eco
299 ate developmental progression towards sex in Cryptosporidium, which has important implications for th
300 system supporting the complete life cycle of Cryptosporidium, while Sateriale et al. (2019) report an