ライフサイエンスコーパス: D-dimer

1 in plasminogen, and a 17.8% net increase in D-dimer.

2 ctively, and a 12.5% (p = 0.042) decrease in D-dimer.

3 atriuretic peptide, interleukin-6 level, and D-dimers.

4 g 25 870 patients who had CTPA order without D-dimer (59% of all tests for PE).

5 antithrombin complex (14.5-50 microg/L), and D-dimers (6.00-27.0 mg/L) increased, whereas fibrinogen

6 ive protein (198 vs. 107 mg/L, P = .010) and D-dimer (8.6 vs. 2.1 ug/mL, P = .004) levels, and lower

7 involved direct detection of CRP whereas for D-dimer a two-site immunoassay employing a biotinylated

8 D-dimer, a fibrin degradation product, generated followi

9 e YF, we found high concentrations of plasma D-dimer, a fibrin split product, suggestive of a concurr

10 Levels of D-dimers, a marker of thrombosis, failed to correlate wi

11 Sustained elevation of D-dimer after decannulation may indicate thrombosis.

12 cile increase), and higher concentrations of D-dimer (aHR 1.10 [1.01-1.19] per decile increase) were

13 intravascular coagulation (DIC) (fibrinogen, D-dimer, alpha-2-antiplasmin, antitrombin, prothrombin t

14 test, smoking history, sex and the levels of D-dimer among two groups.

15 .33) for t-PA antigen, 1.01 (0.95, 1.07) for D-dimer and 1.11 (1.05, 1.18) for VWF.

16 n T and lower lymphocyte count, but elevated D-dimer and C-reactive protein.

17 d-dimer and cell injury markers (HMGB1, histones) confir

18 seven healthy volunteers and correlated with D-Dimer and CTOI.

19 OVID-19 presents with prominent elevation of D-dimer and fibrin/fibrinogen-degradation products, wher

20 es PMA formation in vitro, along with plasma d-dimer and fibrinogen levels were also measured.

21 test screening, including the measurement of D-dimer and fibrinogen levels, is suggested.

22 r there is any corelation of the Wells rule, D-dimer and LDH values with computerized tomography pulm

23 Elevated admission D-dimer and peak D-dimer were associated with venous thr

24 D-dimer and plasmin-antiplasmin complex levels increased

25 rticipants, transient increases in levels of d-dimer and prothrombin fragments 1 and 2 were observed,

26 D-dimer and soluble tissue factor levels were significan

27 trunk and to study the relation between the D-dimer and the uni- or bilateralism of the lesions and

28 e at the interface of the two domains of the DS dimer and confirms the design strategy for allosteric

29 e production of fibrin degradation products (D-dimer) and consumption of platelets.

30 of coagulation (eg, as measured with plasma D-dimer) and thrombocytopenia have emerged as prognostic

31 , coagulation (prothrombin fragment F1+2 and d-dimer), and endothelial damage (thrombomodulin) marker

32 able state with elevated C-reactive protein, D-dimer, and ferritin.

33 lder age; elevated C-reactive protein (CRP), D-dimer, and fibrinogen levels; tachycardia; thrombocyto

34 L-6, CRP [C-reactive protein], TNF-alpha R1, D-dimer, and fibrinogen).

35 tes mellitus, higher body mass index, higher d-dimer, and greater severity of hypoxemia on ICU admiss

36 CRP, TNF, sIL-6R, I-FABP, sCD14, D-dimer, and HA levels were elevated in acute HIV infect

37 Myeloperoxidase, D-dimer, and matrix metalloproteinase 9 were not modifie

38 ifference was observed in the levels of FDP, D-dimer, and MPV among the three groups of the patients.

39 s calculated based on platelets, fibrinogen, d-dimer, and prothrombin index.

40 ng high-sensitivity C-reactive protein, IL6, d-dimer, and systemic tumor necrosis factor receptors I

41 Elevated levels of C-reactive protein, d-dimer, and troponin were found in 100%, 91%, and 71% o

42 sminogen activator inhibitor type 1 [PAI-1], D-dimer, and von Willebrand factor [vWF]) were measured

43 al pro B-type natriuretic peptide, ferritin, D-dimers, and cardiac troponin in addition to high C-rea

44 The PAI-1/tPA complexes, D-dimers, and prothrombin fragment F1 + 2 were measured

45 f coagulation exacerbation as fibrinogen and D-dimers, and were increased in patients requiring invas

46 14 [sCD14]), coagulation cascade activation [D-dimer], and fibrosis (hyaluronic acid [HA]) were measu

47 to which is immobilised a histidine tag anti-D-Dimer antibody.

48 , activated partial thromboplastin time, and d-dimer as well as the DIC score differed significantly

49 Wells score, in combination with a negative d-dimer assay.

50 obability of pulmonary embolism and negative d-dimer assay.

51 esults may not be generalizable to different D-dimer assays from the one used in the study.

52 Results may not be generalizable to all D-dimer assays or patients with previous DVT, study pers

53 s in patient characteristics, use of various d-dimer assays, and limited statistical power to assess

54 n peptides that are responsible for covalent D-dimer association, as well as dozens of novel cross-li

55 Measurement of clinical plasma sample with a D-dimer at concentration of 437 ng/mL with 15 biofunctio

56 Elevated D-dimer at initial presentation was predictive of coagul

57 enia, and elevation in inflammatory markers, D-dimer, B-type natriuretic peptide, IL-6, and IL-10 lev

58 suggest the potential for implementation of D-dimer based protocols to reduce low-yield CTPA orderin

59 26.6%-29.9%) and 337 patients (11.6%) had a D-dimer between 500 microg/L and their age-adjusted cuto

60 e bedside tools (clinical decision rules and D-dimer blood tests) for patients with low pretest proba

61 44-85%; P<0.001 for both), and reductions in D-dimer by 24% (95% CI, -30% to -18%), von Willebrand fa

62 mbophilia, and inflammation (LDH, bilirubin, D-dimer, C-reactive protein [CRP]) improved.

63 dly elevated inflammatory markers (ferritin, D-dimer, C-reactive protein) and elevated neutrophil:lym

64 patients testing positive for COVID-19, and d-dimer can be used to stratify patients in terms of PE

65 Consequently, D-dimer cannot be used to exclude DVT without an assessm

66 C-reactive protein, procalcitonin, ferritin, D-dimer, cardiac troponin T, and N-terminal pro-B-type n

67 The C-statistic for D-dimer concentration was 0.874 +/- 0.065.

68 ted with VTE risk up to Day 10 (P=0.017) and D-dimer concentration with VTE risk up to Day 35 (P=0.00

69 D-dimer concentrations are elevated in nearly all corona

70 As a result, D-dimer concentrations at 6, and 8 hours, and blood fibr

71 levels increased soon after start of NMP and D-dimer concentrations correlated significantly with lev

72 Baseline plasma D-dimer concentrations ranged from 0.6 to 1.7 mug/L for

73 ponin-T, creatine kinase-MB, fibrinogen, and D-Dimer concentrations were measured at baseline, at 1,

74 te ED patients who had any of the following: D-dimer, CTPA, scintillation ventilation perfusion lung

75 validated and compared with the conventional D-dimer cutoff level of 500 ug/L.

76 s 50.7%) when compared with the conventional D-dimer cutoff level to rule out thromboembolic disease

77 stimated glomerular filtration rate-adjusted D-dimer cutoff levels (> 333 ug/L [estimated glomerular

78 D-Dimer cutoff levels adjusted for renal dysfunction app

79 stimated glomerular filtration rate-adjusted D-dimer cutoff levels are applied.

80 Furthermore, adjusted D-dimer cutoff levels seem reliable in patients with acu

81 acteristics were also observed when adjusted D-dimer cutoff levels were applied in patients with acut

82 stimated glomerular filtration rate-adjusted D-dimer cutoff levels.

83 Compared with a fixed D-dimer cutoff of 500 microg/L, the combination of prete

84 ants on the basis of a negative age-adjusted D-dimer cutoff result.

85 cal probability assessment with age-adjusted D-dimer cutoff was associated with a larger number of pa

86 D-dimer (DD) is highly sensitive for AAS but is inadequa

87 termined and patients grouped by this and by D-dimer (DD) levels.

88 D-dimer declined with ATV/r and DRV/r and was unchanged

89 Levels of PTF1+2, FDP, and D-dimer decreased as symptoms improved.

90 its detection; and 3) discusses the role of D-dimer determination in these various conditions.

91 High concentrations of D-dimer early after start of NMP can be considered a mar

92 ive protein, fibrinogen, total homocysteine, D-dimer, factor VIII, plasmin-antiplasmin complex, and i

93 Reduced levels of D-dimer (fibrin degradation product) were evident in tic

94 physiology was observed as platelet counts, d-dimer, fibrinogen levels, and serum chemistries remain

95 roponins, plasminogen activator inhibitor-1, D-dimer, fibrinogen, C-reactive protein, sST2, galectin-

96 tests including ESR, CBC with differential, D-dimer, fibrinogen, C3, C4, IL-6, etc.

97 nhibitor-1, aldosterone, C-reactive protein, D-dimer, fibrinogen, homocysteine, and growth differenti

98 L-6 appeared to be a stronger predictor than D-dimer for CVD and non-AIDS-defining malignancies, but

99 s results, suggests a model in which the PGL DD dimer forms a fundamental building block for P-granul

100 in whom PE could be excluded on the basis of D-dimer from 43 of 673 patients (6.4% [95% CI, 4.8%-8.5%

101 TF ELISA, soluble P-selectin, d-dimer, FVIII, and C-reactive protein were assayed.

102 lized ratio (INR) 1.3, fibrinogen 199 mg/dL, D-dimer greater than 1.0 mug/mL, and fibrin split produc

103 D-dimer greater than 2,600 ng/mL predicted venous thromb

104 ciated complications during hospitalization (D-dimer >2500 ng/mL, adjusted odds ratio [OR] for thromb

105 7.82 (1.95-31.38) in validation cohort for a D-dimer >4 mg/L vs </=4 mg/L.

106 In addition, D-dimer has been evaluated for determining the optimal d

107 Consequently, D-dimer has been extensively investigated for the diagno

108 (hazard ratio, 1.09 [95% CI, 1.08-1.11]) and D-dimer (hazard ratio, 1.10 [95% CI, 1.02-1.20]) predict

109 essment score, lower PaO2/FIO2 ratio, higher D-dimer, higher C-reactive protein, and receipt of mecha

110 lipoprotein particle concentration, leptin, d-dimer, homoarginine, and N-terminal pro B-type natriur

111 etermination of C-reactive protein (CRP) and D-dimer in human blood plasma based on a white light int

112 The structure, containing L- and D-dimers in a centrosymmetric space group, revealed unex

113 e investigated whether persistently negative D-dimers in patients with vein recanalization or stable

114 oluble [s]CD14 and sCD163), and coagulation (D-dimer) in HIV-infected and uninfected never, former, a

115 WR also increases blood level of D-dimer, indicative of ongoing coagulation and thromboly

116 Matriptase processes the FL-D dimer into a GFD dimer (GFD-D) in a stepwise manner, i

117 D-dimer is a soluble fibrin degradation product that res

118 This review: 1) describes how D-dimer is generated; 2) reviews the assays used for its

119 Ultrasound evaluation is recommended if D-dimer is greater than 2,000 ng/mL (sensitivity 95%, sp

120 %) and empiric anticoagulation considered if D-dimer is greater than 5,500 ng/mL (sensitivity 53%, sp

121 D-dimer is used as a biomarker within blood for the diag

122 bability, the negative predictive value of a D-dimer less than 500 ng/mL is 92%.

123 p = 0.013) and in patients with a decline in D-dimer less than or equal to 50% (odds ratio, 2.76; p =

124 tPA and uPA, attenuated ICH, lowered plasma d-dimers, lessened thrombocytopenia, and improved neurol

125 2.32), interleukin 6 level (aHR, 2.34), and D-dimer level (aHR, 1.95) were associated with mortality

126 inclusive cohorts: patients with an elevated d-dimer level (cohort 1), patients with an elevated d-di

127 A normal D-dimer level (ie, D-dimer <500 ng/mL) excludes acute VT

128 4.1 +/- 1.1 [95% CI: 13.8, 14.4]; P = .035), d-dimer level (P < .001), lactate dehydrogenase level (P

129 gh-sensitivity C-reactive protein level, and D-dimer level all strongly predicted mortality, even aft

130 tionship, almost zero, was found between the D-dimer level and gender.

131 sTNFR-I level, sTNFR-II level, KT ratio, and D-dimer level at year 1 were associated with the occurre

132 btain any imaging studies in patients with a d-dimer level below the age-adjusted cutoff.

133 The 3-month failure rate in patients with a D-dimer level higher than 500 microg/L but below the age

134 ical probability, 817 patients (28.2%) had a D-dimer level lower than 500 microg/L (95% CI, 26.6%-29.

135 luded 315 patients who had a low C-PTP and a d-dimer level of 500 to 999 ng per milliliter (95% CI, 0

136 A combination of a low C-PTP and a d-dimer level of less than 1000 ng per milliliter identi

137 st that pulmonary embolism is ruled out by a d-dimer level of less than 1000 ng per milliliter in pat

138 esting in outpatients with a low C-PTP and a d-dimer level of less than 1000 ng per milliliter or wit

139 linical pretest probability (C-PTP) and by a d-dimer level of less than 500 ng per milliliter in pati

140 dered to be ruled out with a low C-PTP and a d-dimer level of less than 500 ng per milliliter would r

141 er milliliter or with a moderate C-PTP and a d-dimer level of less than 500 ng per milliliter.

142 level (cohort 1), patients with an elevated d-dimer level or an age of at least 75 years (cohort 2),

143 clinical or laboratory findings of elevated D-dimer level or elevated lactate dehydrogenase (LDH) le

144 atients with a Wells score </=4 and a normal d-dimer level or no d-dimer testing) (override group) an

145 The mean d-dimer level was 1774 ng/mL and 6432 ng/mL d-dimer unit

146 none of the three criteria were met and the d-dimer level was less than 1000 ng per milliliter or if

147 more of the three criteria were met and the d-dimer level was less than 500 ng per milliliter.

148 f the pulmonary trunk and the correlation of D-dimer level with the uni-or bilateralism of the lesion

149 ts with Wells score >4 or </=4 with elevated d-dimer level) (adherent group).

150 group (25 of 589 studies, none with a normal d-dimer level) and 11.2% in the adherent group (270 of 2

151 c injury (troponin level), and fibrinolysis (D-dimer level).

152 asma biomarkers (interleukin 6 [IL-6] level, D-dimer level, high-sensitivity C-reactive protein [hsCR

153 e dehydrogenase (LDH) level, ferritin level, d-dimer level, neutrophil count, and neutrophil-to-lymph

154 cutely ill medical patients with an elevated d-dimer level, there was no significant difference betwe

155 the most likely diagnosis) and measured the d-dimer level.

156 el, kynurenine-to-tryptophan (KT) ratio, and D-dimer level.

157 </=3500 ng/mL), whereas significantly higher D-dimer levels (>3500 ng/mL) were in found in livers wit

158 blood platelet counts (P < .001) and higher D-dimer levels (P < .001).

159 hite blood cell count (P = .005), and higher D-dimer levels (P = .044) were also significantly associ

160 vs 5, p<0.002), were associated with higher D-dimer levels (p<0.01) and were associated with more se

161 I (P=0.003), higher WBC (P=0.005) and higher D-dimer levels (P=0.044) were also significantly associa

162 atient group in terms of elevated LDH or/and D-dimer levels (P=0.263 and P=1.000, respectively).

163 Normal D-dimer levels after withdrawal of anticoagulant therapy

164 mia patients had higher fibrinogen but lower d-dimer levels and platelet counts than drowning patient

165 strongest" weak correlation resulted between D-dimer levels and the axial diameter of the pulmonal tr

166 -sensitivity C-reactive protein (hsCRP), and D-dimer levels are linked to adverse outcomes in human i

167 Among all DIC parameters, D-dimer levels are most predictive for thrombosis with a

168 e PE is highly unlikely in these patients if d-dimer levels are normal.

169 terminal pro-B-type natriuretic peptide, and d-dimer levels at baseline.

170 d-dimer levels closest to CT pulmonary angiography date

171 ly reported fever and myalgia, and had lower D-dimer levels compared to White patients (p&0.05).

172 ary embolisms and the degree of elevation of D-dimer levels does not differ between patients with COV

173 e [CLT]) and a 5% slower rate of increase in D-dimer levels during clot degradation (D-Drate; all P <

174 21%), an unlikely score combined with normal d-dimer levels excluded UEDVT.

175 tudy was to evaluate the correlation between D-dimer levels in positive thromboembolic thoracic compu

176 In both patients, plasma D-dimer levels increased with clinical evidence of disea

177 cholesterol decreased significantly, whereas D-dimer levels increased.

178 rter reaction times compared with those with D-dimer levels less than or equal to 2,000 (4.8 vs 5.6 m

179 line low BMI and hemoglobin and high CRP and D-dimer levels may be clinically useful predictors of IR

180 We present 2 cases that indicate that D-dimer levels may be useful as a potential biochemical

181 There were no significant differences in D-dimer levels or the location of pulmonary embolisms be

182 Thus, quantification of D-dimer levels serves an important role in guiding thera

183 When adjusted D-dimer levels were applied, test characteristics remain

184 Elevated plasma D-dimer levels were associated with acute C1-INH-HAE att

185 Higher sCD14, CRP, and D-dimer levels were associated with higher peripheral bl

186 rtiles and log2-transformed IL-6, hsCRP, and D-dimer levels were calculated using Cox models.

187 Median plasma D-dimer levels were comparable across treatment groups a

188 2550 [310-8410] mug/l saline); median plasma D-dimer levels were decreased by Day 7 in both groups (4

189 Plasma D-dimer levels were elevated in 80% of the patients (med

190 terminal pro-B-type natriuretic peptide, and d-dimer levels were measured at baseline.

191 CCR5(+) monocytes positively associated with D-dimer levels, CCR2(+) monocytes were inversely associa

192 was reflected by up to 1,000-fold increased d-dimer levels, greater than 5-fold elevated plasmin ant

193 s stasis activated fibrinolysis, measured by D-dimer levels, in alpha2AP(-/-) mice vs alpha2AP(+/+) m

194 ignificant effect on plasma interleukin-6 or D-dimer levels, nor on monocyte/T-cell activation, mucos

195 This retrospective study showed that D-dimer levels, the diameter of the pulmonal trunk, the

196 ; in those with an unlikely score and normal d-dimer levels, UEDVT was excluded.

197 - or bilateralism of thromboembolism and the D-dimer levels, we also found a weak correlation.

198 levels but normalization of TNF, sIL-6R, and D-dimer levels.

199 ad a Wells score of 4 or less and had normal d-dimer levels.

200 gnificantly associated with higher sCD14 and D-dimer levels.

201 n test showed no correlation between LDH and D-dimer levels.

202 fected C-reactive protein, interleukin 6, or D-dimer levels.

203 ch clinical disease activity correlates with D-dimer levels.

204 avirus disease 2019 (COVID-19) have elevated D-dimer levels.

205 onth-old chronic residual thrombi and normal D-dimer levels.

206 iously shown to be associated with increased D-dimer levels.

207 A normal D-dimer level (ie, D-dimer <500 ng/mL) excludes acute VTE when combined wit

208 a-free hemoglobin, platelets, and decline in D-dimer <= 50% the day after decannulation), cannula siz

209 ine low BMI and hemoglobin, and high CRP and D-dimer may be clinically useful predictors of IRIS and

210 ntify high short-term risk, whereas elevated D-dimer may be suggestive of high midterm risk.

211 Clinicians should obtain a high-sensitivity d-dimer measurement as the initial diagnostic test in pa

212 Clinicians should not obtain a d-dimer measurement in patients with a high pretest prob

213 D-dimer measurement is an important step in the diagnost

214 Serial D-dimer measurement is suitable in clinical practice for

215 icularly computed tomography (CT) and plasma d-dimer measurement, may not improve care while potentia

216 2-level Wells score for PE; highly sensitive D-dimer measurement; and computed tomography pulmonary a

217 We show the potential value of D-dimer measurements as a marker of vasculocentric and/o

218 CTICE ADVICE 2: Clinicians should not obtain d-dimer measurements or imaging studies in patients with

219 They received serial D-dimer measurements using commercial assays with predef

220 edian, 135 pg/mL) and macrophage activation (D-dimer median, 5284 ng/mL).

221 ge, renal function, or biomarkers except for D-dimer (median, 12,858 ng/mL [interquartile range, 3,17

222 We have discovered that the domain-swapped (DS) dimer of hCRBPII undergoes a large and robust confor

223 D-dimers on the day of CT pulmonary angiography had a pr

224 it (54.5%-75.8%) and on whether the standard D-dimer or age-adjusted D-dimer was used.

225 There were no linkages between PBV/PAenh and D-dimer or CTOI.

226 ther analyses were performed using troponin, D-dimer, or ferritin.

227 Linear regression showed that increased D-dimer ordering correlated with increased PE yield rate

228 Centers with higher D-dimer ordering had higher yield of PE on CTPA.

229 IP-10 (P = .0011), TNF-RII (P = .0002), and D-dimer (P = .0444) were also found in coinfected patien

230 f IL-6 (P < .001) but not hsCRP (P = .15) or D-dimer (P = .20) as a predictor for different end point

231 Fibrinogen (P<0.05) and D-Dimer (P<0.05) concentrations were significantly eleva

232 prothrombin fragment F1 + 2 (P = 0.031) and D-dimers (P = 0.044) were significantly lower in plasma

233 >=2 dose-adjustment criteria, reductions in D-dimers (p interaction = 0.20) and PF1+2 (p interaction

234 oximal DVT alone, higher C-reactive protein, D-dimer, peak thrombin, lower Ks, shorter lag phase, dec

235 t F1 + 2 (marker of coagulation activation), D-dimer, plasmin-antiplasmin complex, tissue plasminogen

236 sus warfarin on population pharmacokinetics, D-dimer, prothrombin fragment 1 + 2 (PF1+2), and clinica

237 In 319 patients (78%) who had 2 negative D-dimer results and did not restart anticoagulant therap

238 ith a first unprovoked VTE who have negative D-dimer results is not low enough to justify stopping an

239 Although D-dimer, sepsis physiology, and consumptive coagulopathy

240 Numerous studies have shown that D-dimer serves as a valuable marker of activation of coa

241 active protein, interleukin-6 (IL-6), GlycA, D-dimer, soluble CD14 (sCD14), sCD163, and sIL-2r; blood

242 We compared D-dimer, soluble CD14, and interleukin 6 levels before a

243 processing regulates the deposition of PDGF-D dimer species into the extracellular matrix (ECM) with

244 Age-adjusted cutoff levels increase D-dimer specificity and may decrease overuse of imaging

245 moderate C-PTP (40 patients) and a negative d-dimer test (i.e., <1000 or <500 ng per milliliter, res

246 rly if concomitant proximal DVT), a positive d-dimer test after stopping anticoagulation, an antiphos

247 stimated glomerular filtration rate-adjusted D-dimer test characteristics.

248 n a "PE-unlikely" Wells score and a negative d-dimer test result (efficiency) was estimated using fix

249 Anticoagulant therapy was stopped if D-dimer test results were negative and was not restarted

250 f the low specificity and sensitivity of the d-dimer test, all pregnant women with suspected pulmonar

251 Wells score of 4 or less but did not undergo d-dimer testing and 26 had a Wells score of 4 or less an

252 ssessment of pretest probability followed by D-dimer testing and imaging with venous ultrasonography.

253 up and the proportion of patients undergoing D-dimer testing and ultrasonography.

254 ng thromboembolic disease typically includes D-dimer testing and use of clinical scores in patients w

255 lls score of 4 or less, CDS alerts suggested d-dimer testing because acute PE is highly unlikely in t

256 Most overrides were due to the lack of d-dimer testing in patients unlikely to have PE.

257 Age-adjusted d-dimer testing is associated with a 5% absolute increas

258 e index event was PE rather than DVT, and/or d-dimer testing is positive 1 month after stopping antic

259 g the 2-level Wells score and the results of D-dimer testing using age-adapted cutoffs.

260 d-Dimer testing was done locally.

261 The failure rate of age-adjusted d-dimer testing was less than 3% in all examined subgrou

262 score </=4 and a normal d-dimer level or no d-dimer testing) (override group) and those in whom prov

263 he combination of a clinical decision score, d-dimer testing, and ultrasonography can safely and effe

264 gorithm combining a clinical decision score, d-dimer testing, and ultrasonography has not been evalua

265 al application of a clinical decision score, d-dimer testing, and ultrasonography.

266 the dichotomized Wells rule and quantitative d-dimer testing.

267 g can be safely withheld compared with fixed d-dimer testing.

268 ts with chest pain, our carrying out LDH and D-Dimer tests will not exclude PTE without CTPA.

269 when the age-adjusted (instead of the fixed) d-dimer threshold was applied.

270 ADVICE 4: Clinicians should use age-adjusted d-dimer thresholds (age x 10 ng/mL rather than a generic

271 ge x 10 microg/L in patients aged >50 years) d-dimer thresholds; their 3-month incidence of symptomat

272 tions of tissue plasminogen activator (tPA), d-dimer, thrombin-antithrombin complex, and cytokines (I

273 tor, interleukin-6, and -10); "coagulation" (D-dimers, thrombin-antithrombin complex); "oxidative str

274 hrombin time international normalized ratio, D-dimer, tissue plasminogen activator (tPA), plasminogen

275 rinogen, activated partial prothrombin time, D-dimer, tissue plasminogen activator (tPA), plasminogen

276 nt-of-care (POC) device for the detection of D-dimer to aid diagnosis of DVT/PE.

277 rix (ECM) with increased binding from the FL-D dimer, to the HD, and to the GFD-D.

278 markers (white blood cell count, fibrinogen, D-dimer, troponin T, N-terminal pro-brain natriuretic pe

279 d-dimer level was 1774 ng/mL and 6432 ng/mL d-dimer units in CT pulmonary angiography-negative and C

280 ificity (71%) for PE diagnosis at 1394 ng/mL d-dimer units.

281 Patients with a D-dimer value between the conventional cutoff of 500 mic

282 vated C-reactive protein level, and a rising d-dimer value over time.

283 us disease 2019 include obesity, an elevated d-dimer value, elevated C-reactive protein level, and a

284 D-dimer values are elevated in the majority of these pat

285 Those with D-dimer values greater than 2,000 were more likely to ha

286 A potential link between mortality, d-dimer values, and a prothrombotic syndrome has been re

287 -A, fibroblast growth factor-2), thrombosis (D-dimer, von Willebrand factor, thrombin-antithrombin II

288 diography was 86% to 100% sensitive, whereas D-dimer was 51.7% to 100% sensitive and 32.8% to 89.2% s

289 whether the standard D-dimer or age-adjusted D-dimer was used.

290 Elevated admission D-dimer and peak D-dimer were associated with venous thromboembolism deve

291 AT (thrombin-antithrombin complex), APC, and D-dimer were monitored over 8 hours after infusion of re

292 okines, thrombin-antithrombin complexes, and D-dimer were not different between nonsurvivors and surv

293 tion during NMP, perfusate levels of ALT and D-dimers were low (</=3500 ng/mL), whereas significantly

294 D-dimers were markedly higher in patients with deep veno

295 tivity, thrombin-antithrombin complexes, and D-dimers were measured as procoagulant markers and marke

296 on and PAC-1 binding, fibrinogen levels, and d-dimers were not associated with VTE.

297 ion (sVCAM-1 and sICAM-1), and coagulopathy (D-dimer) were related to higher CTP values.

298 evels of fibrin degradation products (plasma D-dimers) were assessed before study drug administration

299 ated an allosteric metal binding site in the DS dimer, where ligand binding results in a reversible 5

300 ed in 528 (52.3%) with persistently negative D-dimer who subsequently experienced 25 recurrences (3.0