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1 rolysis of N-acyl-substituted derivatives of d-glutamate.
2 ss a defective UDP-N-acetylmuramoyl-l-alanyl-d-glutamate--2,6-diaminopimelate ligase (MurE), an intac
3 was found that these fusion proteins retain D-glutamate-adding activity and have Km and Vmax values
5 dered solely responsible for biosynthesis of D-glutamate, an essential component of cell wall peptido
6 acterial enzyme that converts l-glutamate to d-glutamate, an essential precursor for peptidoglycan sy
8 , LC-MS/MS further revealed the existence of d-glutamate and d-aspartate, which are poor substrates f
9 sired E-olefin isosteres of L-glutamyl-gamma-D-glutamate and L-glutamyl-gamma-L-glutamate, following
10 shown that both isoforms cocrystallize with d-glutamate as dimers, and the enzyme is in a closed con
12 eted CapD, an enzyme that cleaves poly-gamma-D-glutamate capsule and generates amide bonds with pepti
13 nd the primary constituent of the poly-gamma-d-glutamate capsule of the pathogen Bacillus anthracis.
14 ha, is significantly different than the RacE-D-glutamate complex on the basis of the crystal structur
16 ved only in minimal medium supplemented with D-glutamate, demonstrating that MurI is essential for gr
17 GatD in BCG, which is expected to unmask the D-glutamate diaminopimelate (iE-DAP) NOD-1 ligand, yield
18 -like protein (ChiW) and a putative l-alanyl-d-glutamate endopeptidase (ChiX), and subsequent biochem
19 yme involved in the stereoinversion of L- to D-glutamate for peptidoglycan biosynthesis, glutamate ra
20 hat glutamate racemase is the only source of D-glutamate for peptidoglycan synthesis in M. smegmatis.
21 e relative quantification of d-aspartate and d-glutamate in individual neurons mechanically isolated
23 , because L-glutamate stereoisomerization to D-glutamate is predicted to be closely associated with p
24 = 5.2 x 10(6) M(-1) s(-1)), and l-methionine-d-glutamate (k(cat)/K(m) = 3.4 x 10(5) M(-1) s(-1)).
25 t)/K(m) = 5.8 x 10(6) M(-1) s(-1)), N-acetyl-d-glutamate (k(cat)/K(m) = 5.2 x 10(6) M(-1) s(-1)), and
26 best substrates for this enzyme are N-formyl-d-glutamate (k(cat)/K(m) = 5.8 x 10(6) M(-1) s(-1)), N-a
27 synthase (GshA), UDP-N-acetylmuramoylalanine-D-glutamate ligase (MurD) and glutamate racemase (MurI).
29 bacteria, the peptides consist of l-alanine, d-glutamate, meso-diaminopimelic acid (mDAP) and d-alani
30 are predominantly N-acetylmuramyl-L-alanine-D-glutamate-meso-diaminopimelic acid-D-alanyl-D-alanine,
31 us aureus MurE UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diaminopimelate ligase (MurE) (E.C.
32 main resembles UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-diaminopimelate ligase (MurE), yet the
34 a unique polyglutamic acid polymer in which D-glutamate monomers are joined by gamma-peptidyl bonds.
36 ccine by conjugating the capsular poly-gamma-d-glutamate (PGA) with PA to elicit the production of an
37 n used as a target for drug development, and d-glutamate, synthesized by glutamate racemase (MurI), i
38 yme, catalyzes the ATP-dependent addition of D-glutamate to an alanyl residue of the UDP-N-acetylmura
40 and RacE2 to catalyze the rapid formation of d-glutamate, we have determined that RacE1 and RacE2 are
41 . anthracis RacE1 and RacE2, in complex with d-glutamate, were determined to resolutions of 1.75 A an
42 is responsible for converting l-glutamate to d-glutamate, which is an essential component of peptidog
43 Furthermore, N-acylation of alpha-hydrazino d-glutamate with an amino acid catalyzed by the ATP-gras
44 sible stereoisomerization of L-glutamate and D-glutamate with similar, but not identical, steady-stat