ライフサイエンスコーパス: D-mannose

1 ng was Ca(2+)-dependent and inhibitable with d-mannose.

2 llographically the interactions of FimH with D-mannose.

3 OxA > AsA (erythorbic acid) > L-galactose > D-mannose.

4 e de novo synthesis of GDP-L-fucose from GDP-D-mannose.

5 nts all possible regioisomers when linked to d-mannose.

6 d fully reconstituted by further addition of d-mannose.

7 nnose (TM) core, alpha1-3 or alpha1-6 DM, or D-mannose.

8 DP-linked sugar, GDP-4-amino-3,4,6-trideoxy- d-mannose.

9 for C-3 deoxygenation of GDP-4-keto-6-deoxy-D-mannose.

10 r at C(2) was synthesized in nine steps from D-mannose.

11 teraction between Concanavalin A (Con A) and D-(+)-mannose.

12 begin with the formation of GDP-mannose from d-mannose 1-phosphate and GTP followed by the subsequent

13 wn to lack specificity for its physiological D-mannose 1-phosphate substrate.

14 with and without the bound substrate, alpha-D-mannose 1-phosphate.

15 acterial adhesion antagonists based on alpha-d-mannose 1-position anomeric glycosides using X-ray str

16 re required for its production starting from D-mannose-1-phosphate and GTP.

17 8)F-labeled mannose (2-deoxy-2-[(18)F]fluoro-D-mannose, [(18)F]FDM) for targeting of plaque inflammat

18 ose > D-galactose >> L-glucose approximately D-mannose), 2) inhibited by phloretin, KiPT = approximat

19 WbdD phosphorylates 2-alpha-d-mannosyl-d-mannose (2alpha-MB), a short mimic of the O9a polymer.

20 that the GER1 protein does not act as a GDP-D-mannose 3, 5-epimerase, an enzymatic activity involved

21 se plants were unchanged indicating that GDP-D-mannose 3,5-epimerase is encoded by a separate gene.

22 ar PLP-dependent enzyme, GDP-4-keto-6-deoxy- d-mannose 3-dehydratase or ColD, catalyzes a dehydration

23 of this investigation is GDP-4-keto-6-deoxy-D-mannose 3-dehydratase or ColD, which catalyzes the rem

24 bate synthesis and are interconverted by GDP-D-mannose-3,5-epimerase.

25 ed that ColD functions as GDP-4-keto-6-deoxy-D-mannose-3-dehydrase responsible for C-3 deoxygenation

26 us of this investigation, GDP-4-keto-6-deoxy-d-mannose-3-dehydratase (ColD), catalyzes the third step

27 er PLP-dependent enzyme, GDP-4-keto-6-deoxy- d-mannose-3-dehydratase (or ColD), was determined in our

28 hine decarboxylase, hyaluronan synthase, GDP-D-mannose 4,6 dehydratase, and a potassium ion channel p

29 GDP-D-mannose 4,6-dehydratase catalyzes the first step in th

30 1 gene of Arabidopsis thaliana encodes a GDP-D-mannose 4,6-dehydratase catalyzing the first step in t

31 ing one or the other or both isoforms of GDP-D-mannose 4,6-dehydratase, depending on the cell type an

32 novo synthesis of l-Fuc is catalyzed by GDP-d-mannose 4,6-dehydratase, which, in Arabidopsis, is enc

33 e the genetic locus encoding a mammalian GDP-D-mannose-4,6-dehydratase (GMD).

34 The recombinant protein exhibited GDP-D-mannose-4,6-dehydratase activity in vitro and was able

35 encoding the fucose biosynthetic enzyme GDP-d-mannose-4,6-dehydratase.

36 nucleotide sugar interconversion step, a GDP-D-mannose-4,6-dehydratase.

37 equence similarity to proposed bacterial GDP-D-mannose-4,6-dehydratases and was tightly linked to the

38 (1-azi-2,2,2-trifluoroethyl)benzoyl)-1,3-bis(D-mannose-4-yloxy)-2-p ropylamine in extensor digitorum

39 -azi-2,2, 2-trifluoroethyl)-benzoyl-1,3-bis-(D-mannose-4-yloxy)-2-propyla min e photolabel, were 26-3

40 2,2-trifluoroethyl)benzoyl-1,3-bis-[2-(3)H] (D-mannose-4-yloxy)-2-propylamine exofacial photolabeling

41 cluding beta-D-fructose 6-phosphate and beta-D-mannose 6-phosphate, a precursor and an intermediate o

42 ctose 3, D-glucose 4, D-gulose 5, D-idose 6, D-mannose 7, D-talose 8) selectively labeled with (13)C

43 D-mannose, a C-2 epimer of glucose, exists naturally in

44 Finally, we discover that treatment with D-mannose, a natural bioactive monosaccharide, rescues a

45 were associated with higher NT-proBNP and 2 (d-mannose, acetone) were associated with lower NT-proBNP

46 lpha-D-mannose (MeMan) and mannose-alpha 1,3-D-mannose-alpha-OMe (MeMan-2) have been determined and a

47 ield (longest linear sequence) starting from d-mannose and (S)-propylene oxide as the source of the s

48 glucose/maltose, the protein also recognizes d-mannose and a variety of mannose-rich microbial ligand

49 ific and saturable and could be inhibited by d-mannose and abolished by endoglycosidase H treatment o

50 ic Janus dendrimers with the monosaccharides D-mannose and D-galactose and the disaccharide D-lactose

51 The 2,6-anhydro-heptitols derived from D-mannose and D-galactose are enantiomeric and are usefu

52 1-2Fuc linkages (where Man and Xyl represent d-mannose and d-xylose, respectively), underlying the mo

53 APK activation and AA release are blocked by d-mannose and Dectin-2-specific antibody, and overexpres

54 We found that D-mannose and L-galactose are efficient precursors for a

55 posed pathway of ascorbic acid synthesis via D-mannose and L-galactose is operational in individual P

56 C-5 epimerization of GDP-4-keto-3,6-dideoxy-D-mannose and the subsequent C-4 keto reduction of the r

57 ions with nonspecific substrates (L-glucose, D-mannose, and 2-deoxy-D-glucose).

58 derivatized hexoses, d-glucose, d-galactose, d-mannose, and d-fructose, using only mass spectrometry

59 a-C-glycopyranosyl aldehydes from D-glucose, D-mannose, and D-galactose.

60 nate, D-glucuronate, N-acetyl-D-glucosamine, D-mannose, and D-ribose.

61 values similar to those found with GDP-alpha-d-mannose, and decreased the K(m) of the fluorinated sub

62 espectively, for the hydrolysis of GDP-alpha-d-mannose, and showed smaller effects on K(m), suggestin

63 a branch of D-paratose from the C-3 of alpha-D-mannose, and the C-3 of beta-L-rhamnose is partially O

64 and turnover complexes of Gmm-Ca2+-GDP-alpha-d-mannose, and three cocrystal structures of an inactive

65 tic synthesis of GDP-4-amino-3,4,6-trideoxy- d-mannose are presented.

66 The application of d-mannose as a multipurpose building block from the chir

67 elease ammonia yields GDP-4-keto-3,6-dideoxy-D-mannose as the product.

68 specificity, and reveal that the presence of d-mannose at the +1 subsite renders the acid catalyst le

69 6)]Man) by generating mutants that abolished D-mannose binding but retained mannotriose binding activ

70 - (BTA-beta-d-glucose; BTA-Glc and BTA-alpha-d-mannose; BTA-Man) or disaccharides (BTA-beta-d-cellobi

71 iphery or a monosaccharide (BTA-OEG(4)-alpha-d-mannose; BTA-OEG(4)-Man) at the end of a tetraethylene

72 breast cancer cells unlike per-butanoylated-D-mannose (Bu(5)Man), a clinically tested compound that

73 was attenuated by N-acetyl-D-glucosamine or D-mannose, but not L-mannose, in a dose-dependent manner

74 Here, we show that the uptake of D-mannose by different mammalian cell lines involves a m

75 one, and have synthesized ascorbate from GDP-D-mannose by way of these intermediates in vitro.

76 es of carba-alpha-D-glucosamine, carba-alpha-D-mannose, carba-alpha-D-mannuronic acid, carba-beta-L-i

77 Unlike in the 3-O-methyl-D-mannose-containing polysaccharide (sMMP) series, the a

78 ycosylamines derived from d-glucose (d-Glc), d-mannose (d-Man), d-xylose (d-Xyl), and d-lyxose (d-Lyx

79 carbohydrate recognition domain of SP-A with d-mannose, D-alpha-methylmannose, and glycerol, which re

80 essentially unaltered when it was exposed to D-mannose, D-fucose, D-ribose, L-glucose, or L-galactose

81 saccharides showed the presence of l-fucose, d-mannose, d-galactose, d-glucose, d-glucuronic acid, N-

82 Other saccharides, such as neutral (d-mannose, d-galactose, d-xylose, d-mannoheptaose) and c

83 ts of a repeating pentasaccharide containing d-mannose, d-glucose and l-rhamnose: [See text].

84 otein showed quenching by 2-deoxy-D-glucose, D-mannose, D-glucose or D-galactose in the presence of s

85 accharides found were d-xylose, d-galactose, d-mannose, d-glucose, d-arabinose, d-rhamnose and d-gluc

86 reductive aminocyclization/lactamization of d-mannose/D-glucose derived C5-gamma-azido esters as a k

87 racetylated 2-acetylamino-2-deoxy-3-O-methyl-D-mannose decreases cell surface sialylation in Jurkat c

88 two partial ORFs similar to genes rfbD (GDP-D-mannose dehydratase) and rfbZ (first mannosyl transfer

89 of Atstp1 seed shows reduced sensitivity to D-mannose, demonstrating that AtSTP1 is active before ge

90 e multivalent systems displaying a protected d-mannose derivative or an iminosugar by way of CuAAC.

91 e de novo synthesis of GDP-L-fucose from GDP-D-mannose encompasses three catalytic steps, a 4,6-dehyd

92 KO of two isoforms of GDP-D-mannose epimerase (OsGME) reduced the foliar AsA level

93 h equatorial 4-OH groups competed as well as D-mannose for gp120 binding to DC-SIGN, regardless of ho

94 cificity of 2-acetylamino-2-deoxy-3-O-methyl-D-mannose for MNK.

95 ird, the fluorinated substrate, GDP-2F-alpha-d-mannose, for which a cationic oxocarbenium transition

96 ant for preparation of those 2-azido-2-deoxy-d-mannoses from their corresponding thioglycosides.

97 tamin C) biosynthesis pathway occurs via GDP-D-mannose (GDP-D-Man), GDP-L-galactose (GDP-L-Gal), and

98 n in the presence of GDP-4-amino-4,6-dideoxy-D-mannose (GDP-perosamine).

99 4 --> Leu) Gmm bound to substrates GDP-alpha-d-mannose, GDP-alpha-d-glucose, and GDP-beta-l-fucose.

100 ascorbate biosynthesis pathway involving GDP-D-mannose, GDP-L-galactose, L-galactose and L-galactono-

101 n provided compounds 14 and 15 from low-cost d-mannose in remarkable 43 and 32% overall yields, respe

102 The concentration of D-mannose in serum is 20-50 micron, but its physiologica

103 sity are well characterized, the function of D-mannose in T cell immune responses remains unknown.

104 rtho ester, this being readily prepared from d-mannose in three easy, high-yielding steps.

105 monstrated that supraphysiological levels of D-mannose inhibit tumour growth and stimulate regulatory

106 via high-affinity (1 nM), Ca(2+)-dependent, D-mannose-inhibited binding to the major envelope glycop

107 2-Acetylamino-2-deoxy-3-O-methyl-D-mannose inhibits the human ManNAc kinase domain of the

108 e route developed involves the conversion of D-mannose into a suitably protected diene (13), which is

109 D-mannose is a monosaccharide approximately a hundred ti

110 uired for optimal expression of levFGX; (ii) D-mannose is a potent inducer of the levD and fruA opero

111 Transport of D-galactose and D-mannose is also up to 60% less in Atstp1 seedlings com

112 Perosamine or 4-amino-4,6-dideoxy- d-mannose is an unusual sugar found in the O-antigens of

113 the free energy landscape of isolated alpha-D-mannose is molded on enzyme to only allow one conforma

114 that the binding of the monosaccharide alpha-D-mannose is the primary bladder cell receptor for uropa

115 epines 3 and 4, derived from d-galactose and d-mannose, largely favor alpha- over beta-epoxidation.

116 aldehyde function introduced on the glycans D-mannose (Man) and D-N-acetyl glucosamine (GlcNAc) by t

117 amphiphilic Janus glycodendrimers (GDs) with d-mannose (Man) headgroups, a known routing signal for l

118 The effect of D-mannose (Man) on plant cells was studied in two differ

119 ly unrecognized immunoregulatory function of D-mannose may have clinical applications for immunopatho

120 tructures of GNA complexed with methyl-alpha-D-mannose (MeMan) and mannose-alpha 1,3-D-mannose-alpha-

121 It is not known whether D-mannose metabolism affects the function of non-prolife

122 as well as to the monosaccharides l-fucose, d-mannose, N-acetylglucosamine, N-acetylgalactosamine, a

123 s made between the effects of NADM, NADG and D-(+)-mannose on multi-species oral biofilms.

124 Adherence was inhibited either by 4% D-mannose or by anti-type 1 fimbrial rabbit serum.

125 s selectivity, responding strongly to either D-mannose or D-glucose in a cAMP-independent manner.

126 No alteration in affinity was observed for D-mannose or for alpha1-3- or alpha1-6-linked DM; howeve

127 g(2+), catalyzes the hydrolysis of GDP-alpha-D-mannose or GDP-alpha-D-glucose to yield sugar and GDP.

128 Perosamine (4-amino-4,6-dideoxy- d-mannose), or its N-acetylated form, is one of several

129 The D-mannose pathway appears to be predominant in leaf tiss

130 t and possibly circumvent other steps in the D-mannose pathway to synthesize vitamin C.

131 mployed azido-(Z,Z)-farnesyl phosphoryl-beta-d-mannose probes and took advantage of the strain-promot

132 egions with similarity to dolichol phosphate-D-mannose:protein O-D-mannosyltransferases.

133 In agreement with this finding, D-mannose proved to be a potent axon-promoting factor fo

134 starting from commercially available methyl-D-mannose pyranoside.

135 nction to remove GDP-D-glucose formed by GDP-D-mannose pyrophosphorylase, an enzyme that has previous

136 ow that binding of type 1 fimbriae (pili) to d-mannose receptors triggers a cross talk that leads to

137 His-259 abstracts the H2 proton of the d-mannose residue at the reducing end, and consistently

138 reversibly converts d-glucose residues into d-mannose residues at the reducing end of unmodified bet

139 .08) or fecal strains (P < 0.001) to exhibit D-mannose-resistant hemagglutination of human erythrocyt

140 However, E. coli 83972 did not express D-mannose-resistant or D-mannose-sensitive hemagglutinat

141 Addition of d-mannose restored MICA/B surface expression after 2DG t

142 re we show that supraphysiological levels of D-mannose safely achievable by drinking-water supplement

143 83972 did not express D-mannose-resistant or D-mannose-sensitive hemagglutination after growth under

144 ell adherence was observed in vivo, and weak D-mannose-sensitive hemagglutination was detected after

145 In vitro, D-mannose stimulated Treg cell differentiation in human

146 bolism in adoptively transferred T cells via D-mannose supplementation enhances anti-tumor activity a

147 Furthermore, in vitro expansion with D-mannose supplementation yields T cell products for ado

148 Here, we show that D-mannose suppresses LPS-induced macrophage activation b

149 te to an l-GulA building block from a simple d-mannose thioglycoside.

150 hanism that can be alleviated by addition of d-mannose; this does not, however, affect the inhibition

151 From the inexpensive d-mannose, through a highly functionalized phenylthio ma

152 which catalyzes the hydrolysis of GDP-alpha-D-mannose to GDP and the beta-sugar by nucleophilic subs

153 the MUR1 and GER1 gene products converts GDP-D-mannose to GDP-L-fucose in vitro demonstrating that th

154 rther decreased the k(cat) with GDP-2F-alpha-d-mannose to values similar to those found with GDP-alph

155 Here we identify a metformin-stimulated d-mannose transport (MSMT) activity in dermal fibroblast

156 ST1) has been previously identified as a GDP-d-mannose transporter.

157 Mechanistically, D-mannose treatment induces intracellular metabolic prog

158 ion and demonstrated the requirement for GDP-d-mannose, UDP-d-glucose and dTDP-l-rhamnose in Psl prod

159 H(2) showed about 2.0-fold-increased [(14)C]d-mannose uptake compared to the cells grown without H(2

160 ge activation, our study points towards safe D-mannose utilization as an effective intervention again

161 AAT building blocks from cheap and abundant d-mannose via a one-pot S(N)2 displacement of 2,4-bistri

162 D-mannose was also identified as a substrate.

163 The binding activity of the mono-saccharide D-mannose was delineated from this of mannotriose (Man(a

164 The unique site binding pocket occupied by D-mannose was probed using site-directed mutagenesis.

165 ols response of LPS-activated macrophages to D-mannose, which impairs glucose metabolism by raising i

166 mannoside, 3,6-di-O-(alpha-d-mannopyranosyl)-d-mannose, which is found in the core region of all aspa

167 saccharide 3,6-di-O-(alpha-D-mannopyranosyl)-D-mannose, which is present in all asparagine-linked car

168 accharide, 3,6-di-O-(alpha-D-mannopyranosyl)-D-mannose, which is present in the core region of all as

169 ree generation of C1-substituted glucal from d-mannose, which was further converted to 1,2-disubstitu

170 ylation of various protected 2-azido-2-deoxy-d-mannoses with primary triflate electrophiles afforded