ライフサイエンスコーパス: D. melanogaster

1 D. melanogaster females store sperm in two types of orga

2 D. melanogaster has a relatively simple nervous system b

3 D. melanogaster possess three types of hematopoietic cel

4 D. melanogaster potently suppress sleep in response to s

5 hopper(Bd-we) transposase reading frame to a D. melanogaster hsp70 promoter for a heat-inducible tran

6 ests to easily view and analyse acknowledged D. melanogaster gene sets and compare them with those of

7 Three additional D. melanogaster fly lines with putative mutations in pyr

8 radiation-induced gut permeability in adult D. melanogaster.

9 However, competition also affects D. melanogaster cells with mutations in epithelial polar

10 uired for full oral toxicity of Pf-5 against D. melanogaster, with rhizoxins being the primary determ

11 utant of Pf-5 retained full toxicity against D. melanogaster in a noninvasive feeding assay, indicati

12 This comprehensive account of all D. melanogaster CS helps set the stage for experimental

13 Indeed, 15% of all D. melanogaster genes segregate for potentially damaged

14 The adenosine signal thus allows D. melanogaster to rapidly marshal the energy needed for

15 BMP activity profiles between M. abdita and D. melanogaster.

16 Treating newly emerged Ae. aegypti and D. melanogaster adults with recombinant bursicon (r-burs

17 s set by baseline methods in C. albicans and D. melanogaster, it leaves considerable room and need fo

18 s gene expression datasets of C. elegans and D. melanogaster during their embryonic development.

19 ng free energy for the entire C. elegans and D. melanogaster genomes.

20 bodies of literature such as C. elegans and D. melanogaster to identify papers with any of these dat

21 eukaryotic cells and animals (C. elegans and D. melanogaster) and the incorporation of useful unnatur

22 asts, D. suzukii (a pest of fresh fruit) and D. melanogaster (a saprophytic fly and a neurogenetic mo

23 se (mouse Vasa homolog), Xenopus laevis, and D. melanogaster Vasa proteins contain both symmetrical a

24 fluorescence shift toward green, in mice and D. melanogaster, as well as significantly improved struc

25 rable to conservation between D. miranda and D. melanogaster, which diverged >30 MY ago.

26 ctivate AMP gene promoters from M. sexta and D. melanogaster.

27 ing to reexamine the well-studied Australian D. melanogaster cline.

28 ul comparisons against the current available D. melanogaster reference genome (dm3).

29 Because D. melanogaster is a powerful model system for studying

30 e the first comprehensive comparison between D. melanogaster and C. elegans developmental time course

31 F1 hybrids of interspecific crosses between D. melanogaster and D. simulans and compare them with in

32 We transferred cytoplasm between D. melanogaster embryos carrying mitochondrial mutations

33 st, we find that sequence divergence between D. melanogaster and D. simulans is greater at regulatory

34 ontributes to reproductive isolation between D. melanogaster and closely related species, causing hyb

35 we show that some viruses are shared between D. melanogaster and D. simulans.

36 Given the similarity between D. melanogaster and vertebrate eye development, the larg

37 s involved in naked valley variation between D. melanogaster and D. simulans [5, 6].

38 derstanding of the genetic variation between D. melanogaster reference strains.

39 lele characteristic of African and Caribbean D. melanogaster females (more 5,9-C27:2 and less 7,11-C2

40 Here we analyze the effect of changing D. melanogaster sex comb length on the process of rotati

41 ittle as a five minute exposure to 100% CO2, D. melanogaster exhibited climbing deficits up to 24 hou

42 citrifolia fruit-with its generalist cousins D. melanogaster and D. simulans.

43 y reported viral sequences will help develop D. melanogaster further as a model for molecular and evo

44 ved by testing its activity in the divergent D. melanogaster genome.

45 F-32 in evolutionarily distant species, i.e. D. melanogaster and D. virilis.

46 n and genetic linkage experiments with eight D. melanogaster natural populations collected from Calif

47 ing four species (S. cerevisiae, C. elegans, D. melanogaster and H. sapiens).

48 n and mRNA degradation in yeast, C. elegans, D. melanogaster, and humans by an unknown mechanism.

49 this hypothesis, mutations in four essential D. melanogaster dosage compensation genes are shown here

50 In summary, we have established D. melanogaster as an expedient model system to study th

51 By comparing this new genome to the existing D. melanogaster assembly, we created a structural varian

52 ide (SP) activates JH biosynthesis in female D. melanogaster after mating [14].

53 old, promote reproductive dormancy in female D. melanogaster Furthermore, we provide evidence indicat

54 suppressive effect of reproduction in female D. melanogaster is attributable to the endocrine signal

55 ric division of neuroblasts in the fruit fly D. melanogaster.

56 A lognormal DFE best explains the data for D. melanogaster, whereas we find evidence for a bimodal

57 e lipidomic profiles have been generated for D. melanogaster, little information is available on the

58 To determine sequence elements required for D. melanogaster HLB formation and histone gene expressio

59 species-specific, preferred temperature for D. melanogaster (~25 degrees C).

60 The telomeric retrotransposon HeT-A from D. melanogaster has an unusual promoter near its 3' term

61 and width across species, and is absent from D. melanogaster eggshells.

62 ge population genomic Wolbachia dataset from D. melanogaster.

63 ext-generation paired-end reads derived from D. melanogaster isofemale lines.

64 in Calliphora vicina a species diverged from D. melanogaster by about 100 Myr, spatial expression of

65 d chromosome deletions and duplications from D. melanogaster to map two hybrid incompatibility loci i

66 ly consistent with most other estimates from D. melanogaster and indicate a relatively high rate of a

67 -containing mTR3 and the Cys-orthologue from D. melanogaster (DmTR) to resist inactivation by oxidati

68 s appear to have been acquired recently from D. melanogaster probably via a single horizontal transfe

69 otransposons from D. virilis, separated from D. melanogaster by 40 to 60 million years, to evaluate t

70 tome similarity of developmental stages from D. melanogaster and C. elegans using modENCODE RNA-seq d

71 Here, we report how D. melanogaster use specific hydrocarbons to chemically

72 In D. melanogaster, the bone morphogenetic protein (BMP) si

73 er updated profiles (36 in vertebrates, 3 in D. melanogaster and 4 in A. thaliana; a 9% update in tot

74 e are four TipE-homologous genes (TEH1-4) in D. melanogaster and three to four orthologs in other ins

75 ait, alcohol dehydrogenase (ADH) activity in D. melanogaster, across both historical and novel alcoho

76 With genetic approaches in D. melanogaster and C. elegans, we demonstrate the impor

77 ith the analogous sequence and spacing as in D. melanogaster, providing strong support for the spread

78 uired for the selection of neuroblasts as in D. melanogaster.

79 tant role in maintaining nutrient balance in D. melanogaster.

80 inhibited OR-mediated olfactory behavior in D. melanogaster larvae.

81 ctivities in the natalisin-specific cells in D. melanogaster induced significant defects in the matin

82 patterns of variation in male mate choice in D. melanogaster.

83 zing whole-genome data to identify clines in D. melanogaster and several other systems.

84 uired for the functions attributed to cnn in D. melanogaster.

85 of the Accord insertion allele of CYP6G1 in D. melanogaster natural populations.

86 la and people, pharmacochaperoning of DAT in D. melanogaster may allow us to bridge that gap.

87 ndrially localized aldehyde dehydrogenase in D. melanogaster has two important functions: detoxifying

88 s to our understanding of eye development in D. melanogaster and humans.

89 function required for proper development in D. melanogaster.

90 at it is necessary for larval development in D. melanogaster.

91 me-wide studies of TE population dynamics in D. melanogaster.

92 enome-wide quantification of such effects in D. melanogaster and D. simulans.

93 ype virus but also replicates efficiently in D. melanogaster after removal of the bacterial endosymbi

94 These elements in D. melanogaster differ from nontelomeric retrotransposon

95 For example, in D. melanogaster, the microbiome is reported as flexible

96 When willin is expressed in D. melanogaster epithelial tissues, it has the same subc

97 performed cap analysis of gene expression in D. melanogaster and D. pseudoobscura.

98 ave newly acquired male-biased expression in D. melanogaster are less likely to be dosage compensated

99 S2) fails to drive appreciable expression in D. melanogaster However, we found that a large transgene

100 n has a complex effect on gene expression in D. melanogaster, affecting even those genes that lack BE

101 t gene family show male-biased expression in D. melanogaster, largely in non-reproductive tissues.

102 hat resulted in high levels of expression in D. melanogaster.

103 SNs and PNs have been studied extensively in D. melanogaster, where development is deterministic and

104 in the recent past and swept to fixation in D. melanogaster.

105 , with the ancestral deletion state fixed in D. melanogaster and the derived insertion state at very

106 r COX activity and mitochondrial function in D. melanogaster, thus providing a new tool that may help

107 to systematically probe histone functions in D. melanogaster.

108 Furthermore, in D. melanogaster, TART-A is present at higher copy number

109 Instead, knockdown of these genes in D. melanogaster via RNA interference caused male-biased

110 ry of these principles governing grooming in D. melanogaster demonstrates the utility of incorporatin

111 ate Hippo-pathway-dependent tissue growth in D. melanogaster and that they do this in parallel to the

112 n-coding genes located in heterochromatin in D. melanogaster are enriched with insulator proteins BEA

113 magnitude of crossover rate heterogeneity in D. melanogaster and highlight potential features mediati

114 the first example of allelic inactivation in D. melanogaster.

115 physiological and genetic interrogations in D. melanogaster to uncover the 'glucome', the complete s

116 ate for behavioral reproductive isolation in D. melanogaster.

117 ellular basis of male embryonic lethality in D. melanogaster induced by Spiroplasma.

118 sk alleles caused near-complete lethality in D. melanogaster, with no effect of the G0 nonrisk APOL1

119 Decreased Indy activity extends lifespan in D. melanogaster without significant reduction in fecundi

120 studies on individual neuroblast lineages in D. melanogaster and T. castaneum and additional markers

121 ric imaging (MALDI-MSI) to profile lipids in D. melanogaster tissue sections.

122 ication of a duplication at the Rdl locus in D. melanogaster.

123 iological role of the single Piezo member in D. melanogaster (Dmpiezo; also known as CG8486).

124 ciated with diet-specific gut microbiomes in D. melanogaster Despite observing replicable differences

125 argets of endogenously expressed microRNA in D. melanogaster S2 cells.

126 x additional candidate 3' tailed mirtrons in D. melanogaster.

127 Levels of queuosine modification in D. melanogaster reflect bioavailability of the precursor

128 1% and 2% of new nonsynonymous mutations in D. melanogaster are positively selected, with a scaled s

129 at the tissue tropism of BTV-1/NS3mCherry in D. melanogaster resembles that described previously for

130 cleotides in humans, 24 to 30 nucleotides in D. melanogaster, and uniformly 21 nucleotides in C. eleg

131 cate that the HIP gene is duplicated only in D. melanogaster.

132 y positive selection in paralogs of Or67b in D. melanogaster.

133 Additionally, knock-down of MENA ortholog in D. melanogaster eyeful and sensitized eye cancer fly mod

134 as a repressor of abdominal pigmentation in D. melanogaster.

135 transducers in C. elegans and potentially in D. melanogaster; however, a direct role of its mammalian

136 are all required for humidity preference in D. melanogaster.

137 artly explained by a higher mutation rate in D. melanogaster, we also find significant heterogeneity

138 tonically affects protein evolution rates in D. melanogaster.

139 Examination of the Cyp12d1 region in D. melanogaster wildtype and isoline populations reveale

140 id evolution of piRNA-mediated repression in D. melanogaster was driven primarily by mutation.

141 Previous research in D. melanogaster has also demonstrated that ADH activity

142 ibuted to the evolution of DDT resistance in D. melanogaster.

143 es on both lifespan and stress resistance in D. melanogaster.

144 mmon mechanism for desiccation resistance in D. melanogaster.

145 netic variation in desiccation resistance in D. melanogaster.

146 sters, elicited strong antennal responses in D. melanogaster, but weak antennal responses in electroa

147 and signaling and might also play a role in D. melanogaster ovary development.

148 In addition, we conducted an RNAi screen in D. melanogaster to investigate if positional and express

149 gins of replication, similar to that seen in D. melanogaster.

150 essential role in chromosome segregation in D. melanogaster since the gene's origin less than 15 mil

151 f-of-principle for positive sex selection in D. melanogaster.

152 gh genetic perturbations of BMP signaling in D. melanogaster.

153 hromosome rDNA array is normally silenced in D. melanogaster males, while the Y chromosome rDNA array

154 derlie the evolution of naked valley size in D. melanogaster through repression of shavenoid (sha) [9

155 r evidence suggests that intronic AT skew in D. melanogaster is not affected by proximity to intron e

156 Five decades after the spread in D. melanogaster, we provide evidence that the P-element

157 n levels vary across developmental stages in D. melanogaster, and, consistent with a causal effect, g

158 Genetic studies in D. melanogaster have shown that larval oenocytes synthes

159 A previous study in D. melanogaster used a reporter gene driven by a testis-

160 interslope divergence in D. simulans than in D. melanogaster, with extensive signatures of selective

161 sion in Drosophila virilis parallels that in D. melanogaster, suggesting that transcriptional regulat

162 he nucleolus formation is precisely timed in D. melanogaster embryos and follows the transcription of

163 alyses of interacting sex-specific traits in D. melanogaster with comparative analyses of the conditi

164 asonia vitripennis activate transcription in D. melanogaster cells.

165 ation to transcription start sites (TSSs) in D. melanogaster but not in Anopheles gambiae, Apis melli

166 aspecific differences in the naked valley in D. melanogaster and found that neither Ubx nor shavenbab

167 icular, expression of APOL1 risk variants in D. melanogaster nephrocytes caused cell-autonomous accum

168 is and earlier studies of a related virus in D. melanogaster, we conclude that vertically transmitted

169 t receptors, which detect yeast volatiles in D. melanogaster and mediate critical host-choice behavio

170 in tissues from human and mouse, as well in D. melanogaster and S. cerevisiae.

171 orms are not present in Dipterans, including D. melanogaster, except for an embryo-specific, distantl

172 ppeared in the melanogaster group (including D. melanogaster, D. yakuba, and D. erecta) >13 million y

173 zontal transfer of P elements, which invaded D. melanogaster early last century, demonstrated that ho

174 control, is capable of infecting and killing D. melanogaster larvae.

175 Here, we show that male D. melanogaster detect rivals by using a suite of cues a

176 light chain on the actin cones that mediate D. melanogaster spermatid individualization.

177 te for being part of what could be a natural D. melanogaster and D. simulans core microbiome.

178 at GRK from D. willistoni rescues a grk-null D. melanogaster fly and, remarkably, it is also sufficie

179 ability of female but not male Nicknack-null D. melanogaster.

180 ult Drosophila we show that more than 30% of D. melanogaster carry a detectable virus, and more than

181 Alternate splicing was observed in 31% of D. melanogaster genes, a 38% increase over previous esti

182 To further investigate the ability of D. melanogaster to balance nutrient intake, we examined

183 Our assembly of D. melanogaster revealed previously unknown heterochroma

184 differences in the dig-and-dive behavior of D. melanogaster and the fruit-pest D. suzukii.

185 as 65% CO2 affected the motor capability of D. melanogaster.

186 igene family resident on the X chromosome of D. melanogaster by chromosome engineering and found that

187 r analysis shows that the dot chromosomes of D. melanogaster and D. virilis have higher repeat densit

188 e them with intraspecific control crosses of D. melanogaster.

189 rent size; and (iii) that purified dimers of D. melanogaster F-ATPase reconstituted into lipid bilaye

190 t wit is expressed dynamically in the FCs of D. melanogaster in an evolutionary conserved pattern.

191 anipulations of tkv expression in the FCs of D. melanogaster that successfully recapitulated the sign

192 nd that the functions of a large fraction of D. melanogaster enhancers are conserved for their orthol

193 The ran-like gene of D. melanogaster and D. simulans has undergone recurrent

194 scura neo-X chromosome and microRNA genes of D. melanogaster.

195 ological novelty present in the genitalia of D. melanogaster employs an ancestral Hox-regulated netwo

196 this sequence is enriched in the genomes of D. melanogaster (58 copies versus approximately the thre

197 ionships based on the demographic history of D. melanogaster.

198 f discovery using these and other hybrids of D. melanogaster and D. simulans, resulting in an advance

199 lopmental stages, tissues, and cell lines of D. melanogaster, yielding a comprehensive atlas of 62,00

200 morphological novelty, the posterior lobe of D. melanogaster.

201 that the replication initiation machinery of D. melanogaster unexpectedly undergoes liquid-liquid pha

202 20 individuals from a Ugandan population of D. melanogaster.

203 f variability in the ancestral population of D. melanogaster.

204 yed Y-linked variation in six populations of D. melanogaster spread across the globe.

205 valley size also varies among populations of D. melanogaster, ranging from 1,000 up to 30,000 mum(2).

206 on between Rwandan and French populations of D. melanogaster.

207 indings indicate that the mCrC is the PTP of D. melanogaster and that the signature conductance of F-

208 hod was used to determine the redox ratio of D. melanogaster and validated substantial decrease of re

209 (also known as the neurokinin K receptor of D. melanogaster), now has been recognized as a bona fide

210 FDY is absent in the closest relatives of D. melanogaster, and DNA sequence divergence indicates t

211 Although the high resistance of D. melanogaster may make it uniquely suited to exploit c

212 udates of D. simulans, the sister species of D. melanogaster, are not attractive to other larvae.

213 ding sites for 324 TFs across five stages of D. melanogaster embryo development.

214 ution of Q for G in different life stages of D. melanogaster, D. pseudoobscura, and D. willistoni.

215 utilize a common laboratory raised strain of D. melanogaster to characterize adaptation abilities to

216 We used a field strain of D. melanogaster to test whether surviving parasitism by

217 s of two commonly used laboratory strains of D. melanogaster (Canton-S and Oregon R) influence the fe

218 rate that multiple orthogonal EGI strains of D. melanogaster can be engineered to be mutually incompa

219 simulans, D. sechellia, and three strains of D. melanogaster.

220 The structure of D. melanogaster DJ-1beta is similar to that of human DJ-

221 hput data for population genomics studies of D. melanogaster.

222 cleotide variability, but a formal survey of D. melanogaster Y chromosome variation had yet to be per

223 ave a higher p(+)s (+) compared with that of D. melanogaster and mice.

224 s shaping the developmental transcriptome of D. melanogaster.

225 Additionally, co-transfection of D. melanogaster S2 cells with dual luciferase reporter c

226 and proliferation of the two major types of D. melanogaster blood cells, plasmatocytes and crystal c

227 is is an important finding, given the use of D. melanogaster as a model system for the evolution of i

228 ints, providing tools for future research on D. melanogaster inversions as well as a framework for de

229 comparison to the most recent RNAz screen on D. melanogaster, REAPR predicts twice as many high-confi

230 eralist wasp than a wasp that specializes on D. melanogaster.

231 e we used the genetically tractable organism D. melanogaster to define the neural mechanisms through

232 ociated with variation in life span in other D. melanogaster populations.

233 for eight species: R. sphaeroides, S. pombe, D. melanogaster, C. elegans, Xenopus, zebra fish, mouse

234 es to D. melanogaster telomeres and protects D. melanogaster chromosomes from fusions.

235 changes in ovarian cell number that regulate D. melanogaster ovariole number also regulate ovariole n

236 f five organisms, S. cerevisiae, H. sapiens, D. melanogaster, A. thaliana, and E. coli, and confirm s

237 s data sets for three organisms--H. sapiens, D. melanogaster, and S. cerevisiae--and show that, as co

238 e and explore how natural history has shaped D. melanogaster in order to advance our understanding of

239 Intriguingly, some D. melanogaster nuclear genetic backgrounds can fully re

240 parameters that operate in the model species D. melanogaster.

241 e in two closely related Drosophila species (D. melanogaster and D. sechellia) and their F(1) hybrids

242 We used five standard D. melanogaster laboratory reference strains (Oregon R,

243 In this study, D. melanogaster is investigated as a model for the repli

244 sophila innubila nudivirus (DiNV) suppresses D. melanogaster Toll signalling, suggesting an evolution

245 ptor gene repertoires many times larger than D. melanogaster and exhibit more structurally complex an

246 We found that D. melanogaster genome contains multiple X-linked non-co

247 Here, we show that D. melanogaster females eject male ejaculates from the u

248 signatures of balancing selection across the D. melanogaster distribution range and in their sister s

249 ata within and between populations along the D. melanogaster genome.

250 ree D. simulans clade species as well as the D. melanogaster reference sequence.

251 In contrast, the D. melanogaster TART (TART(mel)) promoter initiates tran

252 The applications of MiMIC vastly extend the D. melanogaster toolkit.

253 a G-protein coupled receptor (GPCR) for the D. melanogaster capa neuropeptides, Drm-capa-1 and -2 (c

254 heterogeneous and able to substitute for the D. melanogaster CTD in supporting fly development to adu

255 incompatible with a nuclear genome from the D. melanogaster strain Oregon-R (OreR), resulting in imp

256 The modENCODE project has improved the D. melanogaster genome annotation by using deep and dive

257 ing multivariate statistical analysis in the D. melanogaster extracts and mouse serum.

258 quantified variation in CHC profiles in the D. melanogaster Genetic Reference Panel (DGRP) and ident

259 Mutations in the D. melanogaster Insulin Receptor (InR) alter SGP cell nu

260 Thus, studies in the D. melanogaster model system can identify candidate susc

261 ca (Cameroon and Zimbabwe) across 63% of the D. melanogaster genome and then sequenced representative

262 and reproduce experimental hallmarks of the D. melanogaster genome organization from independent and

263 The mammalian homologs of the D. melanogaster Grainyhead gene, Grainyhead-like 1-3 (GR

264 which are tuned to specific features of the D. melanogaster song, and from pC1 neurons, which encode

265 Using small segments of the D. melanogaster X chromosome duplicated onto the Y chrom

266 d lethality to a small 24-gene region of the D. melanogaster X.

267 We focused the analysis on the D. melanogaster species and updated the ComiR underlying

268 and show that most male-biased genes on the D. melanogaster X are located outside dosage compensated

269 f crossover events in a 1.2-Mb region on the D. melanogaster X chromosome using a classic genetic map

270 ant incompatible partner locus exists on the D. melanogaster X.

271 We replaced the D. melanogaster HOAP with a highly diverged version from

272 reds of enhancers have been gained since the D. melanogaster-Drosophila yakuba split about 11 million

273 significantly lower ovariole number than the D. melanogaster Oregon R strain.

274 ) that were inserted randomly throughout the D. melanogaster genome.

275 us amount of information now attached to the D. melanogaster genome in public repositories and indivi

276 After aligning the reads to the D. melanogaster genome with TopHat2, we used Cuffdiff2 t

277 The original model simulations fit well the D. melanogaster wild type, but not mutant conditions.

278 lasmid, and creating vectors marked with the D. melanogaster mini-white(+) or polyubiquitin-regulated

279 RanGAP duplication arose recently within the D. melanogaster lineage, exploiting the preexisting and

280 lower TE content in D. simulans compared to D. melanogaster correlates with stronger epigenetic effe

281 Furthermore, in contrast to D. melanogaster, neuroblasts are not selected from prone

282 ulans Nicknack protein can still localize to D. melanogaster heterochromatin and rescue viability of

283 he D. yakuba HOAP ('HOAP[yak]') localizes to D. melanogaster telomeres and protects D. melanogaster c

284 resenting a significant increase relative to D. melanogaster and suggesting the presence of enhanced

285 Relative to D. melanogaster, M. domestica has also evolved an expand

286 these exoproducts and also lacks toxicity to D. melanogaster.

287 how that EPNs vary in their virulence toward D. melanogaster and that Drosophila species vary in thei

288 vectors were successfully used to transform D. melanogaster, and the DsRed vector was also used to t

289 Wild-type D. melanogaster males innately possess the ability to pe

290 Here we use D. melanogaster ovarian GSCs to demonstrate that the dif

291 s study demonstrate the feasibility of using D. melanogaster as a genetic model to investigate BTV-in

292 in a four-field olfactometer assay, whereas D. melanogaster was strongly attracted to these volatile

293 nts by examining extant polymorphism in wild D. melanogaster populations and closely related species.

294 viruses and a DNA virus associated with wild D. melanogaster.

295 t in a way that facilitates comparisons with D. melanogaster.

296 causes lethality in F(1) hybrid females with D. melanogaster.

297 Nucleolar dominance within D. melanogaster is only partially dependent on known com

298 ajority of readthrough events evolved within D. melanogaster and were not predicted phylogenetically.

299 nome-wide signals of recent selection within D. melanogaster.

300 deficient in either carbohydrates or yeast, D. melanogaster show a strong preference for the deficie