ライフサイエンスコーパス: DAF

1 DAF also proved to be compatible with fixation thus allo

2 DAF-16 directly regulates class I genes only, through th

3 DAF-16 expression in muscle cells, but not in neurons, i

4 DAF-16 regulates regeneration independently of lifespan,

5 DAF-18/PTEN, AMP-activated kinase and fatty acid biosynt

6 DAF-2's function in regeneration is mediated by intrinsi

7 DAF-2B arises via alternative splicing and retains the e

8 DAF-7, in turn, activates a canonical TGF-beta signaling

9 DAF-FM staining of NO-challenged wild-type, nor, hmp and

10 son's disease-related-1; parkin)-, or DCT-1 (DAF-16/FOXO-controlled germline-tumor affecting-1)-depen

11 nematodes by activating the TIR-1 - JNK-1 - DAF-16 signaling pathway, and the cell wall component of

12 ppa(2)), and bridging (mu:kappa(1):kappa(1)) DAF coordination modes.

13 either a bridging or nonbridging (kappa(1)) DAF ligand coordinated to each Pd(II) center.

14 ctures consist of three isomeric Pd(kappa(1)-DAF)2(OAc)2 complexes, together with Pd(kappa(2)-DAF)(OA

15 rystal structures of the VEGF/angiopoietin 2 DAF in complex with its two antigens showed highly overl

16 ccumulation began earlier after flowering (2 DAF) in 2011.

17 2(OAc)2 complexes, together with Pd(kappa(2)-DAF)(OAc)2 in which the DAF exhibits a traditional biden

18 of reproduction through the canonical DAF-2-DAF-16 pathway.

19 cumulation was identified between two and 21 DAF characterized by high SFA and PUFA, which decreased

20 zed by high SFA and PUFA, which decreased 21 DAF.

21 ncreased to its highest concentration (30-55 DAF) and SFA and PUFA reached their lowest.

22 Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress susceptibilit

23 sured their susceptibility to infection by a DAF-binding CVB3 isolate.

24 Neuronal DAF-7/TGFbeta causes a DAF-1/TGFbetaR signaling cascade in the gonadal distal t

25 ion and high expression of the SOD-3 gene (a DAF-16-specific target gene) were observed as a result o

26 Self-sperm maintains the expression of a DAF-2 insulin-like antagonist, INS-37, which promotes th

27 In the presence of a DAF-blocking antibody, the reduction in C3b deposition w

28 cell niche, where it negatively regulates a DAF-3 SMAD and DAF-5 Sno-Ski.

29 These compounds do not appear to activate DAF-16 (FOXO orthologue) or mimic dietary restriction (D

30 ingle insulin-like peptide recapitulates all DAF-2-associated phenotypes, likely due to redundancy be

31 g a conserved role for the insulin/IGF-1 and DAF-12 pathways in LIV formation.

32 endogenous Caenorhabditis elegans RHEB-1 and DAF-15/Raptor are expressed ubiquitously and localize to

33 ingly, the nuclear localization of PQM-1 and DAF-16 is controlled by IIS in opposite ways and was als

34 function under the dual control of HSF-1 and DAF-16 transcription factors.

35 n neurons, and required for both DAF-16- and DAF-18-mediated regeneration.

36 osition to the protective role of HLH-30 and DAF-16/FOXO, TOR/LET-363 and the IIS-regulated Zn-finger

37 a negative feedback loop between miR-34 and DAF-16/FOXO.

38 in DPY-21 in the control of dauer arrest and DAF-2 ILS.

39 crine signaling pathways, DAF-7/TGF-beta and DAF-2/Insulin, that confer on the larva diapause and non

40 The EBAX-type CRL and DAF-21 collaboratively regulate SAX-3-mediated axon path

41 mechanism mediated by the EBAX-type CRL and DAF-21/Hsp90 that maintains the accuracy of neuronal wir

42 d DAF S104 at the interface between CVB3 and DAF, and they demonstrate how subtle structural changes

43 tive span acted through DAF-16-dependent and DAF-16-independent pathways upstream of DAF-12, parallel

44 chronic acid respectively to increase ER and DAF-12 coactivation by the sirtuins.

45 y-associated transcription factors FOXO1 and DAF-16 in mammals and worms, respectively.

46 reased expression of innate immune genes and DAF-16/FoxO-Class II genes, and enhanced resistance to P

47 Male sperm induces germline- and DAF-9/DAF-12-dependent shrinking, osmotic stress suscept

48 ulin-like peptide signaling from the gut and DAF-16/FOXO function in AWC.

49 AKT-1/AKT kinase and DAF-16 alter the transcription of mfb-1, which encodes a

50 ch sensitivity by regulating AKT kinases and DAF-16/FOXO.

51 ere it negatively regulates a DAF-3 SMAD and DAF-5 Sno-Ski.

52 dy point to a specific role for VP1 T271 and DAF S104 at the interface between CVB3 and DAF, and they

53 nd point to a specific role for VP1 T271 and DAF S104 at the virus-DAF interface.

54 LET-363/TOR and DAF-15/Raptor are required for development beyond the th

55 e DAF-2 insulin-like pathway that antagonize DAF-16/FoxO activity.

56 find evidence for direct interaction between DAF-3 and the lag-2 promoter.

57 by DAF-16 in neurons, and required for both DAF-16- and DAF-18-mediated regeneration.

58 ctivity and subcellular localization of both DAF-16 and SKN-1 is further modulated by specific posttr

59 We further identify a 25 bp DAF-3 binding element required for the DTC lag-2 reporte

60 mu-DAF)(OAc)]2 , which features two bridging DAF ligands and two terminal acetate ligands, has been c

61 deprivation, odr-10 is directly activated by DAF-16/FoxO, the canonical C. elegans IIS effector.

62 egulated by insulin/IGF1 signaling, bound by DAF-16 in neurons, and required for both DAF-16- and DAF

63 ransforming growth factor-beta ligand called DAF-7, which acts as a neuroendocrine factor that stimul

64 ration of reproduction through the canonical DAF-2-DAF-16 pathway.

65 Furthermore, by composing a four-CCP DAF-MCP chimera with robust CFA (for C3b and C4b) and DA

66 CD55/DAF, one of the regulators of complement activation, is

67 nt in the negative complement regulator CD55/DAF were more sensitive to the high fat diet.

68 e known as dauer by inhibiting the conserved DAF-2 insulin-like signaling (ILS) pathway through incom

69 We crossed DAF(-/-)CD59(-/-) mice with mice deficient in various co

70 Crry(-/-)DAF(-/-) mice were viable on a C3(-/-) background, but p

71 Thus, under in vivo conditions, Crry/DAF deficiency on platelets led to abnormal platelet tur

72 telet Crry in DAF(-/-) mice and studied Crry/DAF-deficient platelet development in vivo.

73 On the basis of the structure of the CVB3-DAF complex determined by cryo-electron microscopy, DAF

74 port a recent pseudoatomic model of the CVB3-DAF interaction obtained by cryo-electron microscopy.

75 nuclear translocation of the cytoprotective DAF-16/FOXO transcription factor and protected from para

76 r patch clamp-mediated dialysis of cytosolic DAF, the remaining NO signals (mostly mitochondrial) wer

77 r (C3aR) signaling abrogates disease despite DAF deficiency, confirming complement dependence.

78 o perform cell-specific rescues, determining DAF-6/patched-related site of action during sensory-orga

79 ylamino-2',7'-difluorofluorescein diacetate (DAF) as a fluorescent NO-sensor that locates to the cyto

80 ylamino-2',7'-difluorofluorescein diacetate (DAF-FM DA).

81 ylamino-2',7'-difluorofluorescein diacetate (DAF-FM), we visualized NO production in individual plate

82 ino-5-methylamino-2',7'-difluorofluorescein (DAF-FM) fluorescent dye, we found that insulin increased

83 Pd(OAc)2 reveal the formation of two dimeric DAF/Pd(OAc)2 complexes at low [DAF] and four monomeric s

84 insulin/IGF-like signaling and its effector DAF-16/FOXO transcription factor.

85 Analyses of elicited DAF(-/-) Foxp3(+) Tregs showed reduced expression of int

86 rdingly, conditional depletion of endogenous DAF-15/Raptor in the soma revealed that TORC1 is require

87 Constitutively expressed DAF was decreased in glomeruli of Hmox1(-/-) rats and au

88 ngiopoietin 2 antibody with dual action Fab (DAF) as a potential therapeutic for neovascular age-rela

89 lifespan-promoting FOXO transcription factor DAF-16 and likely upstream of insulin/IGF signaling.

90 235 synergise with FOXO transcription factor DAF-16 in the insulin signaling pathway.

91 he activity of the FoxO transcription factor DAF-16, we isolated three mutant alleles of dpy-21, whic

92 s regulated by the FOXO transcription factor DAF-16, which contributes to the effects of DAF-2 in neu

93 -21, SET-4 and the FoxO transcription factor DAF-16, which is the main target of DAF-2 ILS.

94 elegans also allows the transcription factor DAF-16/FOXO to induce development into dauer, a diapause

95 ongevity signals to the transcription factor DAF-16/FOXO, a key regulator of lifespan.

96 ing the activity of the transcription factor DAF-16/FOXO.

97 ctivity of the forkhead transcription factor DAF-16/FOXO.

98 PKC that signals to the transcription factor DAF-16/FOXO.

99 enal IRI model in decay-accelerating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice.

100 tein y (Crry) and decay-accelerating factor (DAF) are two murine membrane C3 complement regulators wi

101 tes bind to human decay-accelerating factor (DAF) as well as to the coxsackievirus and adenovirus rec

102 protein (MCP) and decay-accelerating factor (DAF) expression on endothelial cells, giving Factor H (F

103 ay, which induced decay-accelerating factor (DAF) promoter activity via binding to the cAMP response

104 g chimeras of the decay-accelerating factor (DAF) that exhibits DAA and membrane cofactor protein (MC

105 interaction with decay-accelerating factor (DAF), a receptor expressed on the apical cell surface.

106 ollers, including decay accelerating factor (DAF), are gaining emphasis as they minimize injury in va

107 ficiency of CD55 [decay-accelerating factor (DAF)], but the mechanism underlying the linkage remained

108 membrane-anchored Decay Accelerating Factor (DAF, a.k.a.

109 yte expression of decay-accelerating factor (DAF/CD55), a complement C3 convertase regulator, crucial

110 the activation of the transcription factors DAF-16/FOXO and SKN-1/Nrf2.

111 counts of differentially abundant features (DAFs) across different conditions is large.

112 dendritic cells (DCs) from the ovalbumin-fed DAF(-/-) mice showed impaired expression of inducer of c

113 is unaltered by distorted auditory feedback (DAF), deafening gradually weakens synapses on HVCX cells

114 Here, we report a role for DAF-16/FOXO, a transcription factor that is active under

115 A flexible synthesis for DAF-12 ligands and masked ligand derivatives that enable

116 aling pathway, the abnormal DAuer Formation (DAF) 12 nuclear hormone receptor (NHR) pathway, function

117 he stress-response transcription factor FoxO/DAF-16.

118 At the level of host fitness, FoxO/DAF-16 also prevents food scarcity from accelerating the

119 all-intestinal epithelial cells derived from DAF transgenic mice.

120 e a new general method to quantify gBGC from DAF spectra, incorporating polarization errors, taking s

121 Furthermore, DAF-16/FoxO, a target of insulin/insulin-like growth fac

122 alogues as inducers of functional glomerular DAF able to minimize C3b deposition.

123 strate inhibitors, also increased glomerular DAF and reduced C3b deposition after spontaneous complem

124 al Hmox substrate, hemin, induced glomerular DAF.

125 O-1 as a physiologic regulator of glomerular DAF and identify hemin analogues as inducers of function

126 his effect is partially dependent on gonadal DAF-16/FOXO activity.

127 [DAF] and four monomeric species at higher [DAF].

128 quire insulin signaling via the FOXO homolog DAF-16 or the insulin/IGF-1-receptor homolog DAF-2.

129 tagonizing the insulin receptor-like homolog DAF-2 in the postsynaptic neurons RIA, which play an ess

130 DAF-16 or the insulin/IGF-1-receptor homolog DAF-2.

131 ulated by the phosphatase and tensin homolog DAF-18/PTEN.

132 As with its mammalian homologues, DAF-12 function is regulated by bile acid-like steroidal

133 Human DAF permitted CVB3 to bind to the intestinal surface ex

134 generated transgenic mice that express human DAF specifically on intestinal epithelium and measured t

135 However, expression of human DAF did not facilitate infection by the enteral route ei

136 apical cell surface, and expression of human DAF on murine intestinal epithelial cells permits their

137 However, expression of human DAF on the intestinal surface of transgenic mice did not

138 cules in which specific regions of the human DAF molecule were replaced by the corresponding murine s

139 fically eliminated virus attachment to human DAF but had no effect on attachment to CAR or replicatio

140 h murine SCR2 ablated virus binding to human DAF, as did deletion of human SCR2.

141 erstand why CVB3 binds specifically to human DAF, we constructed a series of chimeric molecules in wh

142 Murine DAF, unlike human DAF, does not bind virus, and we hypothesized that the a

143 ormation of the dimeric Pd(I) complex [Pd(I)(DAF)(OAc)](2), followed by (2) a post-burst phase that c

144 implified collection of equilibrating Pd(II)-DAF complexes.

145 Our results implicate DAF-3 repressor complex activity as a key molecular mech

146 view the emerging literature that implicates DAF-12 and potentially other nuclear receptors as novel

147 ame Tregs with little suppressor activity in DAF(-/-) Foxp3-green fluorescent protein mice.

148 he cre-lox system to delete platelet Crry in DAF(-/-) mice and studied Crry/DAF-deficient platelet de

149 C5aR significantly ameliorated renal IRI in DAF(-/-)CD59(-/-) mice, whereas deficiency of C4, Ig, or

150 can largely be explained by perturbations in DAF-16/FOXO target gene expression.

151 combination with a novel ligand-independent DAF-12 activity, to downregulate the critical let-7 fami

152 rapy in combination was sufficient to induce DAF on murine aortic endothelium.

153 ed at the cellular level, with ET-1-induced, DAF-FM-measurable endothelial cell NO production, which

154 span decrease, whereas seminal fluid induces DAF-16-dependent life-span decrease and fat loss.

155 Although the role of intestinal DAF in human infection has not been directly examined, t

156 oform of the nematode insulin receptor (IR), DAF-2B, that modulates insulin signaling by sequestratio

157 One such nuclear receptor is DAF-12, which is required for normal nematode developmen

158 ating factor (DAF) and CD59 double-knockout (DAF(-/-)CD59(-/-)) mice.

159 Glomeruli of patients with FSGS lack DAF and stain positive for C3d, and urinary C3a positive

160 Expression of the TGF-beta ligand DAF-7 in the ASI sensory neurons correlates with and is

161 The TGF-beta ligand DAF-7 likely acts upstream of IIS and links feeding to o

162 Likewise, DAF-37 pheromone receptor signaling negatively modulated

163 f two dimeric DAF/Pd(OAc)2 complexes at low [DAF] and four monomeric species at higher [DAF].

164 resent crystal structures of human RCA (MCP, DAF, and CR1) and a smallpox virus homolog (SPICE) bound

165 plex determined by cryo-electron microscopy, DAF S104 is in close contact with a viral capsid residue

166 The dimeric Pd(I) complex, [Pd(I) (mu-DAF)(OAc)]2 , which features two bridging DAF ligands an

167 Murine DAF, unlike human DAF, does not bind virus, and we hypot

168 04) with the proline residue found in murine DAF eliminated virus binding.

169 ver, the virus does not interact with murine DAF.

170 We demonstrate that expression of the mutant DAF-28 insulin peptide results in endoplasmic reticulum

171 ely lost in backgrounds containing a mutated DAF-16 gene.

172 in we synthesized a push-pull molecule named DAF (Dimethyl Aniline Furaldehyde) that possesses a stro

173 hat induces expression of the neuromodulator DAF-7/TGF-beta.

174 Neuronal DAF-7/TGFbeta causes a DAF-1/TGFbetaR signaling cascade

175 n added to live cells and excited at 405 nm, DAF immediately and brightly stain lipid droplets using

176 enhanced chemiluminescence) and elevated NO (DAF-FM diacetate) levels in NOS1(-/-) myocytes.

177 1 signalling, requiring DAF-18/PTEN, but not DAF-16/FOXO.

178 tively, the results highlight the ability of DAF to equilibrate rapidly among multiple coordination m

179 ved in the phosphorylation and activation of DAF-16.

180 ruginosa, which leads to rapid activation of DAF-7/TGF-beta in ASJ neurons, is insufficient for the e

181 Taking advantage of DAF emission in two distinct channels, ratiometric imagi

182 resent the complex coordination chemistry of DAF and palladium(II) carboxylate salts.

183 ADR induces enzymatic cleavage of DAF from podocyte surfaces, leading to complement activa

184 ives that enable precise temporal control of DAF-12 function was developed.

185 The time course of DAF-T fluorescence in contracting muscle is predicted by

186 at this role is separable from the effect of DAF-16/FOXO on organismal aging.

187 DAF-16, which contributes to the effects of DAF-2 in neuronal aging.

188 O target genes by promoting the exclusion of DAF-16/FoxO from nuclei.

189 ion can be used to trigger the expression of DAF-12 target genes and initiate development from dauer

190 y, dpy-21 mutation reduced the expression of DAF-16/FoxO target genes by promoting the exclusion of D

191 le, given the diverse cellular expression of DAF.

192 weak stimuli did not require the function of DAF-16/FOXO.

193 Herein, we studied the importance of DAF in enabling processes that program tolerance in the

194 diated lifespan extension was independent of DAF-16/FOXO and SKN-1/Nrf2 signaling, but tryptophan and

195 rprisingly, SGK-1 functions independently of DAF-16/FoxO; instead, SGK-1 promotes the cytoplasmic loc

196 time in a manner dependent on inhibition of DAF-16/FOXO by insulin/IGF-1 signalling (IIS).

197 uctive development through the inhibition of DAF-16/FoxO nuclear translocation.

198 d-inducible kinase, and specific isoforms of DAF-16/FOXO transcription factor to regulate fat storage

199 High levels of DAF-16 (in the daf-16 (mu86); muIs61 strain) nuclear acc

200 tion, and diminished nuclear localization of DAF-16/FOXO.

201 pathogen resistance conferred by the loss of DAF-2/16 pathway components.

202 d endosome morphology and mislocalization of DAF-4/BMPRII to late endosomes and lysosomes.

203 and TSP-14 are required for the recycling of DAF-4/BMPRII.

204 study investigated whether up-regulation of DAF by heme oxygenase 1 (HO-1) is an underlying mechanis

205 pensation complex (DCC) in the regulation of DAF-2 insulin-like signaling.

206 The in vivo release of DAF-12 ligands and other small-molecule signals by using

207 Reversal of DAF-15 depletion permits arrested animals to recover to

208 Titration studies of DAF and Pd(OAc)2 reveal the formation of two dimeric DAF

209 SUMOylation of DAF-16 modulates mitochondrial homeostasis by interferin

210 n factor DAF-16, which is the main target of DAF-2 ILS.

211 ethargus results in nuclear translocation of DAF-16.

212 ant immune tolerance, identical treatment of DAF(-/-) mice or DAF(-/-) to WT bone marrow chimeras did

213 Treatment of DAF(-/-)CD59(-/-) mice with an anti-C5 mAb reduced renal

214 and DAF-16-independent pathways upstream of DAF-12, paralleling in adults what has been observed for

215 The use of DAF in combination with other carboxylate ligands (CF3CO

216 rovide valuable insights into the utility of DAF as a ligand in Pd-catalyzed oxidation reactions.

217 amount of difference in total abundances of DAFs across different conditions.

218 human intestinal epithelial cells depends on DAF at the apical cell surface, and expression of human

219 This pathway relies on DAF-16/FOXO activation in vulval tissues to maintain str

220 oth reactions employ 4,5-diazafluoren-9-one (DAF) as an ancillary ligand.

221 4,5-Diazafluoren-9-one (DAF) has been identified as a highly effective ligand in

222 alyzed by a Pd(OAc)2/4,5-diazafluoren-9-one (DAF) system and takes place in acetic or pivalic acid as

223 ed of Pd(OAc)(2) and 4,5-diazafluoren-9-one (DAF).

224 opment are not repressed by DPY-21, SET-4 or DAF-16/FoxO.

225 nce, identical treatment of DAF(-/-) mice or DAF(-/-) to WT bone marrow chimeras did not.

226 in1 acts independently of the GLP-1/Notch or DAF-7/TGF-beta pathways but together with the DAF-2/insu

227 l cues by modulating autocrine and paracrine DAF-2 ILS.

228 two conserved endocrine signaling pathways, DAF-7/TGF-beta and DAF-2/Insulin, that confer on the lar

229 ide receptor NPR-1, and the TGF-beta peptide DAF-7 each have stage-specific effects on behavioral tra

230 glomerulosclerosis involve loss of podocyte DAF, triggering local, complement-dependent, IL-1beta-in

231 an increase in fluorescence of the NO probe DAF-FM after its conversion to DAF-T.

232 expression of the G protein-coupled receptor DAF-37 in specific chemosensory neurons.

233 ough the insulin-like growth factor receptor DAF-2.

234 e controlled by the nuclear hormone receptor DAF-12, an important model for the vertebrate vitamin D

235 bited by the conserved insulin/IGF1 receptor DAF-2.

236 l-surface levels of the BMP type II receptor DAF-4/BMPRII, along with impaired endosome morphology an

237 lins, signaling through the insulin receptor DAF-2, functionally switched the AWC olfactory sensory n

238 en receptor/ER and the worm steroid receptor DAF-12.

239 uced function in the insulin/IGF-1 receptor, DAF-2, various insulins (INS-1 and INS-18), and molecule

240 ngly, we find that the type II BMP receptor, DAF-4 (dauer formation-defective-4), is retromer-indepen

241 interact with the nuclear hormone receptor, DAF-12, to initiate and regulate a rewiring of the genet

242 r (IIS) pathway comprises a single receptor, DAF-2.

243 alate depended upon the longevity regulators DAF-16 and SIR-2.1.

244 bditis elegans, the transcription regulators DAF-16/FOXO and SKN-1/Nrf function to promote longevity

245 Replacing DAF with the structurally related, but more-electron-ric

246 The inferred signal does not require DAF-2/insulin receptor or maintain quiescence of the nea

247 ation of insulin/IGF-1 signalling, requiring DAF-18/PTEN, but not DAF-16/FOXO.

248 S is virulent to normally pathogen-resistant DAF-2/16 insulin-like signaling pathway mutants.

249 r the first time, the engineering of several DAF variants with sub-nanomolar affinity against two str

250 nalysis of derived allele frequency spectra (DAF), but this approach is sensitive to a number of conf

251 agonist of the parasite nuclear receptor Ss-DAF-12, significantly reduced the worm burden in MPA-tre

252 ificantly increased endothelial cell surface DAF and enhanced protection against complement-mediated

253 into the daf-2b genomic locus confirmed that DAF-2B is expressed in vivo and is likely secreted.

254 ings in singing zebra finches, we found that DAF failed to perturb singing-related synaptic activity

255 In addition, we found that DAF-18/PTEN inhibits regeneration independently of age a

256 Our data indicate that DAF-16/FOXO activity in certain somatic gonad cells is r

257 Genetic studies indicate that DAF-2B influences dauer entry, dauer recovery and adult

258 Here, we show that DAF-7/TGFbeta signaling promotes expression of lag-2 in

259 irectly examined, these results suggest that DAF is not the critical factor in mice.

260 after passage through dauer, suggesting that DAF-16/FoxO coordinates environment and life history wit

261 The DAF ligand is unique in its ability to support aerobic c

262 thermosensitive membrane TRP channel and the DAF-16/FOXO transcription factor, but in more complex or

263 itions via the action of AKT kinases and the DAF-16/FOXO transcription factor.

264 Finally, CEH-60 associates with PQM-1 at the DAF-16-associated element within the promoters of stress

265 different signaling cascades, especially the DAF-16 cascade, on lifespan extension by LAB.

266 We show that, in the presence of food, the DAF-2 insulin-like receptor signals through the RAS-ERK

267 esponse programs by controlling noise in the DAF-16/FOXO-regulated gene network.

268 endocrine signaling pathways, including the DAF-2/insulin-like receptor signaling pathway [3-7].

269 To achieve sufficient affinity of the DAF to block both angiogenic factors, we turned to deep

270 rimarily does so through the activity of the DAF-16 transcription factor (forkhead box O (FOXO) homol

271 ilization resulting in the activation of the DAF-16/FOXO and SKN-1/Nrf2 stress response pathways.

272 strong stimuli required the function of the DAF-16/FOXO transcription factor in neurons, but not tha

273 luding four genes encoding components of the DAF-2 insulin-like pathway that antagonize DAF-16/FoxO a

274 est that UNC-104 functions downstream of the DAF-2-signaling pathway and is regulated by the FOXO tra

275 habditis elegans is under the control of the DAF-7/TGF-beta ligand that is secreted from sensory neur

276 aversive learning by modulating not only the DAF-7/TGF-beta pathway but also the G-protein coupled re

277 ly regulates class I genes only, through the DAF-16-binding element (DBE).

278 16.2/ATG16L exert their function through the DAF-16/FOXO transcription factor.

279 velopment (class II) genes by binding to the DAF-16-associated element (DAE).

280 her with Pd(kappa(2)-DAF)(OAc)2 in which the DAF exhibits a traditional bidentate coordination mode.

281 AF-7/TGF-beta pathways but together with the DAF-2/insulin IGF-1 receptor (IIR) signaling pathway to

282 ontrast, ATG-7 functions in concert with the DAF-7/TGF-beta pathway to promote germline proliferation

283 n density on reproductive span acted through DAF-16-dependent and DAF-16-independent pathways upstrea

284 AF, which regulates stress induction through DAF-16/FOXO, does not contribute to ESRE gene expression

285 Thus, DAF is required for the properties of CD103(+) DCs and t

286 reporter response to the environment and to DAF-7/TGFbeta signaling.

287 ng of FoxO6 We then show that FoxO6 binds to DAF-16-binding elements in the Plexin A4 (Plxna4) promot

288 ubiquitin ligase (CRL), EBAX-1 also binds to DAF-21, a cytosolic Hsp90 chaperone.

289 the NO probe DAF-FM after its conversion to DAF-T.

290 wed it to ameliorate renal IRI when given to DAF(-/-)CD59(-/-) mice 24 h before, but not 4 or 8 h aft

291 ctor) orthologue SKN-1 acting in parallel to DAF-16.

292 enome-wide mRNA expression responsiveness to DAF-16 with genome-wide in vivo binding data for a compe

293 Similar to DAF-2/IIR, BEC-1/BECN1/Beclin1, ATG-18/WIPI1/2, and ATG-

294 In turn, SUMO fine-tunes DAF-16 and SKN-1 activity in specific C. elegans somatic

295 sed fat oxidation and energy expenditure via DAF-12-dependent pathway in C. elegans.

296 e results support the current model of virus-DAF interaction and point to a specific role for VP1 T27

297 role for VP1 T271 and DAF S104 at the virus-DAF interface.

298 rry deletion is embryonically lethal whereas DAF-deficient mice are generally healthy.

299 ted in cold sensation in C. elegans, whereby DAF-16/FOXO gets activated via complementary kinase sign

300 centration of NO available for reaction with DAF-FM during bouts of muscle contraction.