ライフサイエンスコーパス: DDT

1 DDT (1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane), a c

2 DDT enhanced both adipogenic and osteogenic differentiat

3 DDT was administered to C57BL/6J dams from gestational d

4 DDT-related and mirex/dechlorane-related compounds were

5 DDTs with demonstrated predictive accuracy for clinical

6 ged since a bottleneck coincident with 1960s DDT spraying campaigns.

7 Insecticide susceptibility to 4% DDT and 0.05% deltamethrin WHO-impregnated papers was de

8 ichlorodiphenyl)-2,2,2-trichloroethane (4,4'-DDT), 1,1-bis(4,4'-dichlorodiphenyl)-2,2-dichloroethene

9 double layer and a high ligand density (3.6 DDT molecules per nm(2)) are at the origin of the appare

10 (BDE 209), 0.1-1.8 (E(3)HBCDD), 1.8-138 (E(6)DDT), 0.1-24.3 (E(3)endosulfan), 0.6-14.6 (E(4)HCH), 9.1

11 Graphic: Pestroy, a DDT-laced coating marketed in 1946 by Sherwin-Williams R

12 There are 3 important questions that a DDT should answer with regard to antituberculosis drugs:

13 PBDEs (92.0%), chlordane (88.5%) and DDT (98.7%) were also detected frequently, although at l

14 reducing the 28-day DDT biouptake (66%) and DDT uptake into PE (>99%) compared to controls.

15 to 52,000 pg/m3 over the sampling area, and DDT, chlordane, and endosulfan concentrations were in th

16 istently over-expressed across carbamate and DDT resistant populations.

17 The composition of chlordane and DDT-related residues indicated recent emissions.

18 Elevated levels of dieldrin, chlordane- and DDT-related pesticides, polycyclic aromatic hydrocarbons

19 mily MIF, D-Dopachrome Tautomerase (DDT) and DDT-like (DDTL) in a lung tissue dataset with 1087 subje

20 pled from walls using Bostik tape discs, and DDT concentrations [grams of active ingredient per squar

21 related significantly with GI, LASRC, DS and DDT.

22 We found higher MIF and DDT expression in COPD patients compared to non-COPD sub

23 erase/dopachrome isomerase activity (MIF and DDT genes).

24 PCBs, PBDEs, and DDT occur at significantly higher concentrations in fish

25 Uptake of HCHs, HCB, PCBs, and DDT plus metabolites was studied (log K(ow) 3.66 to 7.18

26 (carbaryl, cypermethrin, and permethrin) and DDT did not change over time in our study population.

27 prevalence of resistance to pyrethroids and DDT across sub-Saharan Africa from 2005 to 2017, with me

28 utants (POPs), specifically PCBs, PBDEs, and DDTs, in the marine environment are well documented, how

29 We assessed DDT-treated MSCs for self-renewal, proliferation, and di

30 Extractability of sediment-associated DDT and chlordane by A. brasiliensis digestive fluids wa

31 ibers with dodecanethiol-coated AuNRs (AuNRs-DDT).

32 Upon the addition of AuNRs-DDT, P3HT-SH nanofibers were transformed into nanoribbon

33 erent compared to communities present before DDT use, suggesting that a regional organochlorine legac

34 We identified 45 bioaccumulative DDT-related compounds of which the majority (80%) is not

35 performed to identify novel, bioaccumulative DDT-related compounds and to determine their abundance r

36 Both DDT and DDE increase amyloid precursor protein levels, p

37 ese ubiquitination events may be mediated by DDT-dependent E2/E3 ligases (e.g. RAD18 and SHPRH/HLTF).

38 bal use of the endocrine-disrupting chemical DDT has decreased, its persistence in the environment ha

39 of 20 POPs (aldrin, chlordane, chlordecone, DDT, dieldrin, endrin, endosulfan, HBCDD, HCB, HCHs, hep

40 s reveal that ocean dumping of containerized DDT waste was inherently sloppy, with the contents readi

41 cofol, a current use pesticide that contains DDT-related compounds.

42 product of the ubiquitous global contaminant DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane), ha

43 tify bioaccessibility of legacy contaminants DDT and PCBs in marine sediments from a Superfund site.

44 oted AC sequestration by reducing the 28-day DDT biouptake (66%) and DDT uptake into PE (>99%) compar

45 on the uptake of weathered chlordane or DDx (DDT + metabolites) by Cucurbita pepo (zucchini), Zea may

46 d groundwater sludge contaminated with DDXs (DDT, dichlorodiphenyltrichloroethane; and its metabolite

47 Furthermore, defective DDT decreased the numbers of MPP-derived common lymphoid

48 me assessment (COA)--another type of defined DDT--is also discussed.

49 the xenobiotic dichlordiphenyltrichlorethan (DDT), by artificial selection or by transgenic expressio

50 Dichlorodiphenyltrichloroethane (DDT) was reportedly dumped in the area, and sediment ana

51 Dichlorodiphenyltrichloroethane (DDT) was used extensively to control malaria, typhus, bo

52 cohort and dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) serum co

53 throids and dichlorodiphenyltrichloroethane (DDT) but fully susceptible to carbamates and organophosp

54 s), such as dichlorodiphenyltrichloroethane (DDT) and other organochlorine compounds, are abundant in

55 des such as dichlorodiphenyltrichloroethane (DDT) and pyrethroids.

56 es, such as dichlorodiphenyltrichloroethane (DDT), to North American conifer forests during ~1950-197

57 chlordane, dichlorodiphenyltrichloroethane (DDT), malathion, and captan; others with notable but sli

58 containing dichlorodiphenyltrichloroethane (DDT) and chlordane.

59 , including dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenylethylene (DDE),

60 trations of dichlorodiphenyltrichloroethane (DDT) and PCBs show similar spatial distribution patterns

61 els of p,p'-dichlorodiphenyltrichloroethane (DDT), p,p'-dichlorodiphenyldichloroethylene (DDE) and fo

62 e pesticide dichlorodiphenyltrichloroethane (DDT) and its metabolites in intermediate and deep ocean

63 e pesticide dichlorodiphenyltrichloroethane (DDT), were elevated in a small number of patients with A

64 Residual dichlorodiphenyltrichloroethane (DDT) was sampled from walls using Bostik tape discs, and

65 sistance to dichlorodiphenyltrichloroethane (DDT) in field-caught Anopheles gambiae sensu stricto hom

66 related to dichlorodiphenyltrichloroethane (DDT) were the most abundant.

67 pesticide (dichlorodiphenyltrichloroethane, DDT), which had been previously stored in vineyard soil,

68 including dichlorodiphenyltrichloroethylene (DDT, removed from the market in 1972), chlordane (1988),

69 wo different ligands [OAM and dodecanethiol (DDT), respectively] while keeping all other experimental

70 iodide and indium acetate) in dodecanethiol (DDT).

71 Our study proposes a dual DDT-receptor model and provides a structural background

72 t the early time points (6 h to 12 h) during DDT exposure.

73 The bulky trichloromethyl group of each DDT molecule fits snugly between four helices in the ben

74 ted with the decay in residual environmental DDT concentrations and growing human populations, but no

75 ,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT), and tris(2,3-dibromopropyl) phosphate (TDBPP), amo

76 1,1-trichloro-2,2-di(4-chlorophenyl)ethane (DDT) and its metabolites 1,1-dichloro-2,2-bis(4-chloroph

77 1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) and its metabolites had mainly antagonistic effects

78 1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), the first organochlorine insecticide, and pyrethro

79 tifies novel functions of genes-for example, DDT in mitochondrial respiration and WDFY4 in T cell act

80 For DDT, a trend of decreasing net Arctic import will revers

81 DDT-contaminated sediment were assessed for DDT sediment-water flux, biouptake, and passive sampler

82 lowing the regulatory guidance documents for DDT qualification was developed, followed by individual

83 Thus, we sought to determine a role for DDT in renal cancer.

84 nt association with incident RA was seen for DDT (OR = 1.9; 95% CI: 0.97, 3.6).

85 ty (0.97%) reported to permethrin, while for DDT, lambdacyhalothrin, bendiocarb and deltamethrin the

86 Four DDTs were identified as having a track record to answer

87 r to regulate other DDT pathways, error-free DDT mechanisms are employed by H2Bub1-deficient cells as

88 on and activated carbon to reduce risks from DDT-contaminated sediment were assessed for DDT sediment

89 Functionally, DDT and MIF demonstrate a significant overlap in control

90 The extract obtained using Tris-HCl/DDT buffer (pH 8) was used in the pre-treatment of froze

91 However, DDT inhibition consistently displayed more severe effect

92 Together, our findings identify DDT as a functionally redundant but more potent cytokine

93 In DDT IRS households, women who reported taking more than

94 her, our results suggest a role of IGF-1R in DDT.

95 oding RNAs to be differentially expressed in DDT-treated MSCs compared with controls cells.

96 g was performed to assess gene expression in DDT-treated MSCs.

97 Expression of factors in DDT-treated cells was similar to that in estrogen-treate

98 only one isoform (MDR49B) was implicated in DDT resistance.

99 e more strong as indicated by an increase in DDT (2.75 min), DS (3.30 min) and EP (4.20 Wh/kg).

100 d Cyp6g2, and also a concomitant increase in DDT susceptibility.

101 Rad18 is a central E3 ubiquitin ligase in DDT, which exists in a monoubiquitinated (Rad18*Ub) and

102 ential role of MDR49, an ABC transporter, in DDT resistance, however, to date the details of how MDR4

103 e petroleum distillates, potentially used in DDT manufacture, contributed to the waste stream.

104 Median levels of DDT and DDE among women in DDT IRS households were 2.6 (IQR: 1.1-6.6) and 8.5 (IQR:

105 Although both interventions increased DDT resistance, neither increased lifespan.

106 esent a unified theory of turbulence-induced DDT that describes the mechanism and conditions for init

107 The contact insecticide DDT has been reappraised as a safe, life-saving compound

108 he notorious crystalline contact insecticide DDT.

109 , including two organochlorine insecticides (DDT and lindane) and four herbicides (alachlor, metolach

110 oinjection of synthetic miR-310s mimics into DDT-resistant 91-R flies and observed both a significant

111 e.g., covering water and food) had 40% lower DDT levels (95% CI: -63, -0.3%) than women who took fewe

112 ard, rather than a public tap, had 73% lower DDT (95% CI: -83, -57%) and 61% lower DDE (95% CI: -74,

113 Mapping DDT binding sites is necessary for understanding mechani

114 high correlation and that, mechanistically, DDT is a novel hypoxia-inducible gene and direct target

115 surface sediment contamination at the nearby DDT Superfund site.

116 sehold with a low likelihood of DDT use (non-DDT IRS household, n = 106), IRS village in household wi

117 racy of the HFS-TB, or any other nonclinical DDT such as an animal model, has yet to be robustly eval

118 ation of both extractable and nonextractable DDT-related contaminations.

119 and Lambda-cyhalothrin) pyrethroids but not DDT.

120 89.3 +/- 1.8% of DDT, 63.2 +/- 1.9% of DDD, and 50.9 +/- 1.6% of DDE were

121 , to evaluate sensitivity to amelioration of DDT-associated hypertension by ACE inhibition.

122 ulations that would allow reduced amounts of DDT, thereby minimizing environmental impact.

123 st time, we show that aerial applications of DDT to eastern Canadian forests likely resulted in large

124 ations, plays a role in the early aspects of DDT resistance in 91-R.

125 to inhibit MIF signaling may fail because of DDT compensation.

126 pound-specific carbon isotope composition of DDT and its metabolites, and the microbial community in

127 The mean residual concentration of DDT post-IRS was 0.37 g ai/m(2); 84.9% of walls were und

128 ciations of maternal serum concentrations of DDT and DDE during pregnancy with body mass index, obesi

129 Similar concentrations of DDT and DDEs were found in the surface water, while the

130 transformed maternal serum concentrations of DDT, PBDE congeners 28 and 183, and paternal serum conce

131 s revealed a strong cell intrinsic defect of DDT-deficient HSCs in reconstituting lethally irradiated

132 Since the discovery of DDT in the late 1960s, most studies on TLS in eukaryotes

133 Here, using computational docking of DDT into the Kv1.2-based mosquito sodium channel model,

134 The protective effect of DDT required activation of the metabolic stress enzyme A

135 ration of ICI 182,780 blocked the effects of DDT.

136 In addition, a prediction equation of DDT concentrations in soils based on stepwise multiple r

137 es that have contributed to the evolution of DDT resistance in D. melanogaster.

138 We further assessed the influence of DDT exposure on the expression of mRNAs that regulate BP

139 Accordingly, although dual inhibition of DDT and MIF demonstrated additive effects in vitro, DDT

140 Serum concentrations of p,p' isomers of DDT and DDE were above the limit of detection (LOD) in >

141 Median levels of DDT and DDE among women in DDT IRS households were 2.6 (

142 Median levels of DDT and DDE among women in unsprayed villages were 0.3 [

143 in all study lakes still contained levels of DDT-related compounds that exceed PELs.

144 llage in household with a high likelihood of DDT use (DDT IRS household, n = 100).

145 illage in household with a low likelihood of DDT use (non-DDT IRS household, n = 106), IRS village in

146 ts contribute to the majority of the load of DDT-related contaminants in these sentinels of ocean hea

147 Three modes of DDT have been documented: translesion synthesis (TLS), t

148 2006, calls for the complete phasing out of DDT as soon as practical, with limited use in the interi

149 Few studies have examined predictors of DDT (dichlorodiphenyltrichloroethane) and DDE (dichlorod

150 The predictors of DDT and DDE plasma levels identified in the present stud

151 ing to the three-step degradation process of DDT.

152 that H2Bub is required for the regulation of DDT after genome duplication.

153 To investigate the role of DDT in maintaining hematopoietic stem cells (HSCs) and p

154 These findings indicate a critical role of DDT in maintaining HSCs and progenitor cells, and in pre

155 ata indicate that cardiomyocyte secretion of DDT has important autocrine/paracrine effects during isc

156 dumping was found to be the major source of DDT to more than 3000 km(2) of the region's deep seafloo

157 However, the sources of DDT in eastern China are mainly from historic applicatio

158 n the ecosystem, indoor residual spraying of DDT is still recommended for malaria control in Africa.

159 luencing the migration and transformation of DDT isomers and their metabolites in soils.

160 we found that the abiotic transformation of DDT, DDD, and DDE (collectively referred to as DDX) requ

161 e of Indian sand flies, the continued use of DDT in this IRS program is questionable.

162 Although the use of DDT is banned in most of the world due to its detrimenta

163 However, the use of DDT to control vector-borne diseases continues in develo

164 For instance, the elevated concentrations of DDTs in the Barents and Atlantic sectors of the Arctic O

165 Higher concentrations of DDTs were found in the European part of the Arctic Ocean

166 tlantic current as a significant conveyor of DDTs.

167 our understanding of the large-scale fate of DDTs in the Arctic.

168 Due to the adverse impact of DDTs on ecosystems and humans, a full fate assessment de

169 Here, the distribution and inventories of DDTs in water of the Arctic shelf seas and the interior

170 Furthermore, levels of DDTs were associated with increased hepatic fat and circ

171 the migration and transformation pathways of DDTs in Chinese arable soils, which will allow data-base

172 nd an alternative splicing event in MDR49 on DDT-resistance in 91-R, as compared to the DDT susceptib

173 ile H2Bub1 does not appear to regulate other DDT pathways, error-free DDT mechanisms are employed by

174 Peak sedimentary levels of p, p'- and o, p'-DDT (SigmaDDT) and breakdown products SigmaDDE (dichloro

175 ol-induced PEPCK gene expression, while o,p'-DDT and methoxychlor inhibited cortisol-stimulated Arg a

176 The inverse dependence of o,p'-DDT and p,p'-DDE on temperature evidences the transforma

177 We found that plasma levels of o,p'-DDT and p,p'-DDT were independently associated with both

178 with the known estrogenic properties of o,p'-DDT and p,p'-DDT.

179 The EFs and delta(13)C of o,p'-DDT in soils from western China show smaller deviations

180 ds of becoming overweight or obese (for o,p'-DDT, adjusted odds ratio (OR) = 2.5, 95% confidence inte

181 ing all 3 analytical methods, p,p'-DDT, o,p'-DDT, and to a lesser extent p,p'-dichlorodiphenyldichlor

182 -cyhalothrin, cypermethrin, resmethrin, o,p'-DDT, p,p'-DDT, methoxychlor, ethiofencarb, and tolylflua

183 lambda-cyhalothrin, resmethrin, 3-PBA, o,p'-DDT, p,p'-DDT, p,p'-DDE, methoxychlor- and tolylfluanid-

184 cts on all of the receptors, except for o,p'-DDT.

185 sitive associations between exposure to p,p'-DDT and increased adiposity in rodents.

186 We classified p,p'-DDT and p,p'-DDE as "presumed" to be obesogenic for huma

187 ehold wet mopping significantly reduced p,p'-DDT and p,p'-DDE exposure.

188 Median (interquartile range) p,p'-DDT and p,p'-DDE serum concentrations for VHEMBE cohort

189 or malaria control had 5-7 times higher p,p'-DDT and p,p'-DDE serum concentrations than those who nev

190 potential reduction in population-level p,p'-DDT and p,p'-DDE serum concentrations under five hypothe

191 ausibility of the obesogenic effects of p,p'-DDT and p,p'-DDE.

192 g access to water significantly reduced p,p'-DDT exposure and increasing the frequency of household w

193 ound that plasma levels of o,p'-DDT and p,p'-DDT were independently associated with both body mass in

194 confidence interval (CI): 1.0, 6.3; for p,p'-DDT, adjusted OR = 2.1, 95% CI: 1.0, 4.5; and for p,p'-D

195 in, cypermethrin, resmethrin, o,p'-DDT, p,p'-DDT, methoxychlor, ethiofencarb, and tolylfluanid showed

196 Using all 3 analytical methods, p,p'-DDT, o,p'-DDT, and to a lesser extent p,p'-dichlorodiphe

197 halothrin, resmethrin, 3-PBA, o,p'-DDT, p,p'-DDT, p,p'-DDE, methoxychlor- and tolylfluanid-reduced co

198 n estrogenic properties of o,p'-DDT and p,p'-DDT.

199 Typically, models performed better for p,p'-DDT/E than PBDE congeners.

200 antial variability in concentrations of p, p-DDT and its analogs, with a peak concentration of 257 mu

201 ature evidences the transformation of parent DDT to its metabolites.

202 Our results show levels of PBBs, DDT, and HBB in tree bark collected within 10 km of the

203 cate that concentrations of many POPs (PCBs, DDT, HCHs, endosulfan) have declined significantly over

204 Perinatal DDT exposure induces hypertension and cardiac hypertroph

205 verses the hypertension induced by perinatal DDT exposure.

206 We hypothesized that perinatal DDT exposure causes hypertension in adult mice.

207 ajor metabolite of the chlorinated pesticide DDT.

208 e, a nonspecific derivative of the pesticide DDT (1,1-(dichlorobiphenyl)-2,2-dichloroethane), is used

209 Elevated levels of the pesticide DDT (dichlorodiphenyltrichloroethane) have been positive

210 persistent pollutants such as the pesticide DDT and its metabolite p,p'-DDE.

211 ssociation between exposure to the pesticide DDT and its metabolites and obesity to develop hazard id

212 experiments on the organochlorine pesticides DDT, DDE, DDD, and chlordane in well-mixed slurries supp

213 Prenatal DDT exposure is associated with elevated blood pressure

214 e, among boys, 10-fold increases in prenatal DDT and DDE concentrations were associated with increase

215 of knockdown resistance (kdr) to pyrethroids/DDT resistance observed in Anopheles funestus across Afr

216 t several intervention approaches may reduce DDT/DDE exposure in pregnant women living in IRS communi

217 AC treatment was effective in reducing DDT and chlordane concentration in polyethylene (PE) sam

218 mitted to both agencies, pursuing regulatory DDT endorsement.

219 360, 91.3%) of pre-IRS samples had residual DDT concentrations of <0.1 g ai/m(2).

220 olyubiquitin chain by Ubc13-Mms2/Rad5 routes DDT to the template switching pathway.

221 ntibody-dependent neutralization of secreted DDT exacerbated both ischemia-induced cardiac contractil

222 We measured maternal peripartum serum DDT and urine pyrethroid metabolite concentrations and c

223 biodynamic model were developed to simulate DDT flux and biouptake, respectively, and models confirm

224 We generated cardiomyocyte-specific DDT knockout mice (Myh6-Cre Ddtfl/fl), which demonstrate

225 r abundance relative to the commonly studied DDT-related compounds.

226 he MIF family MIF, D-Dopachrome Tautomerase (DDT) and DDT-like (DDTL) in a lung tissue dataset with 1

227 hers has described D-dopachrome tautomerase (DDT) as a functional homologue of MIF with a similar gen

228 D-dopachrome tautomerase (DDT) is an enzyme that lacks physiologic substrates in m

229 its family member D-dopachrome tautomerase (DDT)) in genitourinary cancers and how it can be therape

230 es of these compounds, we analyzed technical DDT, the primary source of historical contamination in t

231 ainly from historic application of technical DDTs and dicofol.

232 wing DDE, and TCPMOH loads were greater than DDT.

233 DFDT and MFDT were much faster killers than DDT, and their amorphous forms were even faster.

234 We find that DDT expression mirrors MIF expression in ccRCC tumor sec

235 Here, we observed that DDT is highly expressed in murine cardiomyocytes and sec

236 Chandrasekhar-mass SNIa model and show that DDT is almost inevitable at densities of 10(7) to 10(8)

237 The results showed that DDT and its first degradation products, DDD (dichlorodip

238 Our results suggest that DDT and DDD are transformed by surface intermediates for

239 e II/III domain interface and suggested that DDT binds within PyR1.

240 at in estrogen-treated MSCs, suggesting that DDT may function via the estrogen receptor (ER)-mediated

241 Accumulating evidence suggests that DDT exposure has long-term adverse effects on developmen

242 The DDT pathways, which involve translesion synthesis and te

243 of racemic/standard compound, indicating the DDT residues there mainly result from atmospheric transp

244 Given the poor quality of the DDT-based IRS, ready availability of pyrethroids, and su

245 f clean sediment (0.5 cm) did not reduce the DDT flux when bioturbation was present, while a thin (0.

246 cm) AC cap was still capable of reducing the DDT flux by 94%.

247 n DDT-resistance in 91-R, as compared to the DDT susceptible strain 91-C.

248 ize the surface of CIS NCs obtained with the DDT method.

249 n of experimental quantitative output in the DDTs that correlates with sterilizing effect in humans.

250 The role of the DDTs used for evaluating the efficacy of antituberculosi

251 Regulatory endorsement of these DDTs is critical for drug developers, as it promotes con

252 Doubling the levels of the sums of these DDTs was associated with insulin insensitivity (-0.38 Ma

253 Dysregulation of this DDT pathway in human cells leads to increased mutation r

254 dicators such as DS, dough development time (DDT), LASRC and gluten index (GI) were positively relate

255 ht a decrease in the dough development time (DDT; 2.03 min), dough stability (DS; 3 min) and peak ene

256 An alternative to DDT, giving year-round transmission control in sub-Sahar

257 Exposure of human neuroblastoma cells to DDT or DDE increased levels of amyloid precursor protein

258 MSCs exposed to DDT demonstrated profound alterations in self-renewal, p

259 Adult mice perinatally exposed to DDT exhibited chronically increased systolic BP, increas

260 MSCs exposed to DDT formed fewer colonies, suggesting a reduction in sel

261 man mesenchymal stem cells (MSCs) exposed to DDT were used to evaluate the impact on stem cell biolog

262 hypertension in mice perinatally exposed to DDT.

263 nd associations between prenatal exposure to DDT and DDE and several measures of obesity at 9 years o

264 data demonstrate that perinatal exposure to DDT causes hypertension and cardiac hypertrophy in adult

265 Results suggest that prenatal exposure to DDT is related to elevated birth size.

266 gambiae sensu stricto to survive exposure to DDT.

267 Development of resistance to DDT and pyrethroids is a serious global obstacle for man

268 Sand flies were highly resistant to DDT but susceptible to deltamethrin.

269 on infectious blood were more susceptible to DDT than mosquitoes that fed on noninfectious blood duri

270 These findings suggest that exposure to DDTs may contribute to the risk of metabolic disease amo

271 DNA damage tolerance (DDT) enables bypassing of DNA lesions during replication

272 main regulator of the DNA damage tolerance (DDT) pathway.

273 bypass is mediated by DNA damage tolerance (DDT) pathways and homologous recombination (HR).

274 age may be overcome by DNA damage tolerance (DDT) pathways that bypass such obstacles, postponing rep

275 e often bypassed using DNA damage tolerance (DDT) pathways to avoid prolonged fork stalling and allow

276 proceed via one of two DNA damage tolerance (DDT) pathways, allowing replicative DNA synthesis to res

277 is due to an aberrant DNA Damage Tolerance (DDT) response upon fork stalling.

278 The first nonclinical drug development tool (DDT) advanced by the Critical Path to TB Drug Regimens (

279 riments, represents a drug development tool (DDT) with the potential for use to develop tuberculosis

280 Several nonclinical drug-development tools (DDTs) have been used for antituberculosis drug developme

281 er and develop novel drug development tools (DDTs), such as biomarkers.

282 The geographically total DDT concentrations are higher in eastern than western Ch

283 tivariable models of natural log-transformed DDT plasma levels (in micrograms per liter) and DDE (in

284 r the deflagration-to-detonation transition (DDT) remains unclear.

285 ven the lack of a gold-standard tuberculosis DDT, the forecasting accuracy of a completely unreliable

286 to sodium channel model, we predict that two DDT molecules can bind simultaneously within PyR1 and Py

287 , we used Pcna(K164R/K164R) mice as a unique DDT-defective mouse model.

288 positions and revealed 10 previously unknown DDT-sensing residues within PyR1 and PyR2.

289 re, we show that anthropogenic chemical use (DDT; dichlorodiphenyltrichloroethane) and increasing urb

290 household with a high likelihood of DDT use (DDT IRS household, n = 100).

291 MIF demonstrated additive effects in vitro, DDT plays a dominant role in tumor growth in vivo.

292 for formal quantitative analyses of how well DDTs forecast clinical outcomes.

293 Among households where DDT is likely to be used for IRS, education regarding ho

294 However, whether DDT binds to both pyrethroid receptor sites remains unkn

295 elanogaster has been intensely selected with DDT over six decades.

296 porting to have lived in a home sprayed with DDT for malaria control had 5-7 times higher p,p'-DDT an

297 levels among residents in homes sprayed with DDT for malaria control with the aim of identifying expo

298 those who never lived in a home sprayed with DDT.

299 Furthermore, treatment with DDT protected isolated hearts against injury and contrac

300 cation of a two end-member mixing model with DDTs and polychlorinated biphenyls enabled source differ