ライフサイエンスコーパス: DEN

1 DEN administration caused greater increases in serum int

2 DEN administration increased the levels of malondialdehy

3 DEN exposure promoted production of IL-6 in Kupffer cell

4 DEN rats showed an increase in echointensity from 37.1 +

5 DEN treatment also reduced survival of LKO mice compared

6 DEN treatment induced p53-independent PUMA expression, P

7 DEN-1 was subsequently detected by RT-PCR from cell cult

8 DEN-induced HCCs with constitutive Notch2 signaling (DEN

9 DEN/PB treatment was associated with specific degradatio

10 e elucidate the role of human deneddylase-1 (DEN-1, also called SENP8) in inflammatory responses in v

11 uble fragment E (sE) of dengue virus type 1 (DEN-1).

12 from the patient, confirmed dengue virus 1 (DEN-1) infection.

13 virus serotypes, i.e., DEN-1 (strain 16007), DEN-2 (16681), DEN-3 (16562), and DEN-4 (1036) viruses b

14 , i.e., DEN-1 (strain 16007), DEN-2 (16681), DEN-3 (16562), and DEN-4 (1036) viruses by over 4 log10,

15 inhibit replication of DEN virus serotype 2 (DEN-2 virus) in mammalian cell culture.

16 four genotypes) of dengue virus serotype 2 (DEN-2) can induce the development of human-like disease,

17 f IFN-alpha against dengue virus serotype 2 (DEN-2).

18 ived from the genome of dengue virus type 2 (DEN-2) capable of forming dsRNA.

19 broad neutralizing activity against 19 of 20 DEN subtypes.

20 The live attenuated dengue virus type 4 (DEN-4) vaccine candidate virus rDEN4 Delta 30 was previo

21 eans of weekly oral gavage with 5 mL of 1.5% DEN solution per kilogram of body weight for 3-11 weeks,

22 at constitutive Notch2 signaling accelerates DEN-induced HCC formation.

23 by alternately passaging a non-mouse-adapted DEN strain between mosquito cells and mice, thereby mimi

24 Additionally, DEN(N2ICD) mice develop large hepatic cysts, dysplasia o

25 After DEN injection, CXCR6-deficient mice had a significantly

26 not develop liver cancer with age and after DEN injections due to failure to activate gankyrin and e

27 ver nuclear extracts of both genotypes after DEN exposure, the complex formed in MTKO mice was predom

28 e, treatment with an IRAK1/4 inhibitor after DEN administration reduced serum IL-6 levels and liver t

29 , resulting in diminished liver injury after DEN exposure.

30 transferred into CXCR6-deficient mice after DEN injection.

31 Apoptosis assays performed monthly after DEN treatment showed no differences between mutant and w

32 Nine months after DEN, SV1 transgenic mice with Klf6 depletion had the gre

33 mmatory cytokines in LKO liver shortly after DEN exposure indicates predisposition of a pro-tumorigen

34 ers of serum neutralizing antibodies against DEN-4.

35 S exhibited hepatoprotective effects against DEN/CCl4-induced injury by reducing DCLK1 expression and

36 ole in the antiviral activity of IFN against DEN-2 replication.

37 MRI and liver histology of alcohol+DEN mice shows hepatobiliary cysts, early hepatic neopla

38 in 16007), DEN-2 (16681), DEN-3 (16562), and DEN-4 (1036) viruses by over 4 log10, in most cases to b

39 , TrxR1-null livers showed altered basal and DEN-exposed metabolomic profiles compared with WT livers

40 The 5' cap and DEN 3' UTR were the main sources of the translational ef

41 so seen in the (D)(V/K) results with DMN and DEN for the minor products resulting from the denitrosat

42 P450 2E1 oxidized DMN and DEN to aldehydes and then to the carboxylic acids.

43 n the pre-steady-state oxidations of DMN and DEN to aldehydes.

44 eled) aldehydes in the oxidations of DMN and DEN to carboxylic acids.

45 parameters measured for oxidation of DMN and DEN to the aldehydes and for oxidation of the aldehydes

46 DMN and DEN were also oxidized to HCO(2)H and CH(3)CO(2)H, respe

47 western blot analysis in both human HCC and DEN-induced murine tumors.

48 CCC formation in patients and DEN(N2ICD) mice is accompanied by re-expression of hepat

49 rom mosquito-borne flaviviruses (WN-rED3 and DEN-rED3) were similar to each other yet distinct from r

50 and increases rates of both spontaneous and DEN carcinogen-induced HCC.

51 HCA and HCC in DEN/carbon tetrachloride and DEN/TCPOBOP induced liver tumors.

52 A effectively inhibited HepG2-xenografts and DEN-induced-HCC in C57BL/6 mice.

53 Analyses of WA-treated HepG2-xenografts and DEN-induced-HCC tumors showed elevated levels of ERK, RS

54 The signaling events and anti-DEN-2 activities of IFN-alpha and IFN-gamma were reduced

55 lly hybridized to labeled sense or antisense DEN-2 RNA derived from the target region of the genome.

56 activator, in mice significantly attenuates DEN-induced liver tumor formation.

57 ocyte-specific deletion of IKKbeta augmented DEN-induced hepatocyte death and cytokine-driven compens

58 Importantly, LNPs were also able to boost DEN-80E specific CD4+ and CD8+ T cell responses.

59 matically reduced the LNP's ability to boost DEN-80E specific immune responses, highlighting the cruc

60 HCC or core-enhanced HCC incidence caused by DEN/Pb.

61 to TNF-alpha, whose expression is induced by DEN, and JNK activity is required for normal hepatocyte

62 he oxidative stress and apoptosis induced by DEN.

63 n be initiated by exposure to the carcinogen DEN, which has been shown to rely upon activation of NF-

64 se FGF21 is induced in response to chemical (DEN treatment) and genetic-induced hepatocarcinogenesis

65 backbone reversion, the safety of ChimeriVax-DEN vaccines would not be compromised.

66 sions produced by the tetravalent ChimeriVax-DEN vaccine were significantly less severe than those ob

67 yellow fever virus-dengue virus (ChimeriVax-DEN) vaccine candidates against dengue virus types 1 to

68 onstruct chimeric YF/DEN viruses (ChimeriVax-DEN), the premembrane (prM) and envelope (E) genes of ye

69 s influenced cancer progression, we compared DEN-induced cancer malignancy under chronically low oxid

70 The immune factors that control DEN infection or contribute to severe disease are neithe

71 in impairs the liver's ability to counteract DEN-induced oxidative stress and enhances tumorigenesis

72 emonstrating that RIPK1 deficiency decreases DEN-induced liver tumor formation in a TNFR1-dependent m

73 Dengue (DEN) is a mosquito-borne disease caused by four DENV ser

74 lammatory cytokines induced during a dengue (DEN) virus infection plays a role in either protection o

75 a worst-case recombinant, ChimeriVax-dengue (DEN) 4 virus was chimerized with the WT Asibi yellow fev

76 The mosquito-borne disease dengue (DEN) is caused by four serologically and genetically rel

77 Five dengue (DEN) virus-specific R5F2R4 peptide-conjugated phosphorod

78 s of previously described monovalent dengue (DEN) virus vaccine candidates were compared to a tetrava

79 guanosine cap-binding pocket of the dengue (DEN) and yellow fever (YF) virus MTase enzymes.

80 ed with those of each wild-type (WT) dengue (DEN) virus representing serotypes 1 to 4.

81 Diethylnitrosamine (DEN) injection induce DSBs along with elevation in the n

82 Diethylnitrosamine (DEN)/carbon tetrachloride (CCl4) extensively induced exp

83 ependent apoptosis, in a diethylnitrosamine (DEN)-induced liver carcinogenesis model.

84 ing HCC in response to a Diethylnitrosamine (DEN)/Phenobarbital (PB) liver tumor-induction protocol.

85 s of mice treated with a diethylnitrosamine (DEN)/phenobarbital tumor induction protocol.

86 o rats were administered diethylnitrosamine (DEN) orally for 12 weeks to induce hepatic fibrosis.

87 eed oil extracts against diethylnitrosamine (DEN) and phenobarbital (PB) induced hepatic injury in ra

88 tocytes protects against diethylnitrosamine (DEN)-induced HCC.

89 f c-Fos protects against diethylnitrosamine (DEN)-induced HCCs, whereas liver-specific c-Fos expressi

90 ular carcinoma (HCC) and diethylnitrosamine (DEN)-induced mouse hepatocarcinogenesis.

91 (NO) in spontaneous and diethylnitrosamine (DEN)-initiated and/or phenobarbital (Pb)-promoted HCC de

92 arcinogenesis induced by diethylnitrosamine (DEN) produced large carcinomas in all AhR-/- mice but mo

93 cinogenesis triggered by diethylnitrosamine (DEN).

94 carcinogenesis caused by diethylnitrosamine (DEN).

95 to the liver carcinogen diethylnitrosamine (DEN) and fed diets with well-defined sugar and fat conte

96 known hepatic carcinogen diethylnitrosamine (DEN).

97 tiated by the carcinogen diethylnitrosamine (DEN).

98 epatocellular carcinogen diethylnitrosamine (DEN).

99 CC induced by carcinogen diethylnitrosamine (DEN).

100 n a chemical carcinogen, diethylnitrosamine (DEN).

101 y the genotoxic chemical diethylnitrosamine (DEN), a hepatic carcinogen that is not an AHR ligand.

102 njection of 10 micro g/g diethylnitrosamine (DEN) and continued administration of phenobarbital (PB)

103 ith the hepatocarcinogen diethylnitrosamine (DEN).

104 to the hepatocarcinogen diethylnitrosamine (DEN).

105 by the hepatocarcinogen diethylnitrosamine (DEN).

106 ation of liver cancer in diethylnitrosamine (DEN)-treated CUGBP1-S302A mice showed these mice develop

107 hout the tumor initiator diethylnitrosamine (DEN) at 5 weeks of age and then orally inoculated with H

108 mice by intraperitoneal diethylnitrosamine (DEN) injection.

109 itrosamine (DMN) and N,N-diethylnitrosamine (DEN), to alkyl diazohydroxides (which are DNA-alkylating

110 l, were susceptible to N-diethylnitrosamine (DEN)-induced liver cancer, indicating that loss of these

111 nitrosodiethylamine [N,N-diethylnitrosamine (DEN)], the intrinsic KIE was slightly lower and was not

112 ed with a combination of diethylnitrosamine (DEN) and CCl4, along with either LPS or E. coli infectio

113 en a single injection of diethylnitrosamine (DEN) followed by weekly doses of carbon tetrachloride to

114 were given injections of diethylnitrosamine (DEN) to induce liver cancer and alpha-galactosylceramide

115 raperitoneal delivery of diethylnitrosamine (DEN), a known carcinogen, induced HCC at 6 months in TG

116 , low-dose injections of diethylnitrosamine (DEN), a mouse model induced by carbon tetrachloride (CCl

117 er a single injection of diethylnitrosamine (DEN), SV1 hepatocyte transgenic mice developed more hist

118 main cellular origin of diethylnitrosamine (DEN)-induced hepatocellular carcinoma (HCC) and are high

119 rates the development of diethylnitrosamine (DEN)-induced hepatocellular carcinoma.

120 peritoneal injections of diethylnitrosamine (DEN); 2 weeks later, some mice also received left and me

121 Using the procarcinogen diethylnitrosamine (DEN) to initiate tumorigenesis in mice, we discovered th

122 We show that diethylnitrosamine (DEN)-induced murine HCC is attenuated by antibody-mediat

123 Using the diethylnitrosamine (DEN) HCC carcinogenesis model, we further show that cons

124 In this study, the diethylnitrosamine (DEN)-induced liver tumor model and the chronic carbon te

125 In the diethylnitrosamine (DEN)-induced mouse hepatocarcinogenesis, we demonstrated

126 WT) mice were exposed to diethylnitrosamine (DEN) and induction of HCC was monitored at 23 and 33 wee

127 much more susceptible to diethylnitrosamine (DEN)-induced acute liver injury and liver carcinogenesis

128 are hypersusceptible to diethylnitrosamine (DEN)-induced hepatocarcinogenesis.

129 ground were treated with diethylnitrosamine (DEN) and sacrificed at 32 weeks old.

130 Cre; Rosa(YFP) mice with diethylnitrosamine (DEN), followed by multiple injections of carbon tetrachl

131 Diethylnitrosoamine (DEN)-mediated liver cancer in wild-type mice also involv

132 y neutralizing against genotypically diverse DEN-4 viruses.

133 iters of all four DEN virus serotypes, i.e., DEN-1 (strain 16007), DEN-2 (16681), DEN-3 (16562), and

134 -derived dendritic cell cultures with either DEN or Sindbis virus, another positive-strand RNA virus,

135 gnant hepatocyte transformation and enhanced DEN-carcinogenesis.

136 RB deletion in the mouse liver enhances DEN-induced tumorigenesis, associated with increased hep

137 DCLD RNA contained the entire DEN 5' and 3' untranslated regions (UTRs), as well as th

138 satory proliferation and prevented excessive DEN-induced carcinogenesis in Ikkbeta(Deltahep) mice.

139 based on the percentage of cells expressing DEN-2 envelope (E) antigen 7 days after challenge.

140 cantly up-regulated in livers of alcohol-fed DEN-injected mice compared to controls.

141 Here we show that alcohol-fed DEN-injected mice have higher ALT and liver-to-body weig

142 er-to-body weight ratio compared to pair-fed DEN-injected mice.

143 ion (LMBDL) and, then 1 week later, were fed DEN, in corn oil, weekly by oral gavage (DLD).

144 mutagenic O6-ethyldeoxyguanosines following DEN challenge in livers of GSNOR-deficient (GSNOR(-/-))

145 Interestingly, however, following DEN treatment, TrxR1-null livers developed threefold few

146 otably, short-term iNOS inhibition following DEN treatment had little effect on carcinogenesis in wil

147 osis and compensatory regeneration following DEN treatment, and does not require the HBV X protein.

148 precursors improves cell survival following DEN treatment to a level indistinguishable from ACC-defi

149 At 35 weeks following DEN exposure, LKO mice exhibited a higher incidence of m

150 The (D)k(app) for DEN was approximately 3 and not expressed in non-competi

151 0 microM 3'CS reduced the titers of all four DEN virus serotypes, i.e., DEN-1 (strain 16007), DEN-2 (

152 ) formulation seroconverted against all four DEN virus serotypes.

153 with TV-1 and TV-3 seroconverted to the four DEN components by day 28 with neutralization titers rang

154 o aldehydes (HCHO from DMN and CH(3)CHO from DEN).

155 iferative genes when compared with HCCs from DEN-induced control mice (DEN(ctrl) HCCs).

156 ation of which also protected male mice from DEN-induced hepatocarcinogenesis.

157 after stimulation with Ags from heterologous DEN serotypes.

158 educed circulating concentrations of IL-6 in DEN-treated male mice.

159 tivation was also significantly augmented in DEN-exposed MTKO livers.

160 s showed METAVIR fibrosis grades of F2-F4 in DEN rats and F0-F1 in controls.

161 liver weights were significantly greater in DEN-treated wild-type or heterozygous mice.

162 tes are the cell of origin of HCA and HCC in DEN/carbon tetrachloride and DEN/TCPOBOP induced liver t

163 iated compensatory proliferation observed in DEN-injured ERRalpha-null livers is concomitant with inc

164 Mechanistically, hepatocyte proliferation in DEN-treated P2y(2)r (-/-) mice was reduced, which correl

165 chemokine receptor-4 (CXCR4), was reduced in DEN-induced MMP10-deficient mice livers.

166 Despite the oncogenic function of STAT3 in DEN-induced liver tumor, hepatocyte-specific STAT3 knock

167 umors and surrounding normal liver tissue in DEN-treated HNF4alpha knockout mice showed significant i

168 ed to complete abolition of tumorigenesis in DEN-exposed beta-cat KO.

169 gamma and TNF-alpha responses to inactivated DEN Ags were detected in up to 0.54 and 1.17% of total c

170 tumorigenesis that correlated with increased DEN-induced hepatocyte apoptosis.

171 also suppressed diethylnitrosamine-induced (DEN-induced) hepatocarcinogenesis, as an increased numbe

172 1 showed reduced diethylnitrosamine-induced (DEN-induced) liver tumorigenesis that correlated with in

173 ack of RIPK1 kinase activity did not inhibit DEN-induced liver tumor formation, showing that kinase-i

174 eriments showed that 5'SL and 3'CS inhibited DEN-2 virus replication in a dose-dependent and sequence

175 beta receptor-mediated action limits initial DEN replication in extraneural sites and controls subseq

176 begins to provide mechanistic insights into DEN-induced disease in vivo.

177 controls were given a single intraperitoneal DEN injection and followed for 6-12 months for hepatic t

178 an isolate, which can be used to investigate DEN pathogenesis and to evaluate candidate vaccines and

179 s in which translation factors are limiting, DEN can alternate between canonical cap-dependent transl

180 red with HCCs from DEN-induced control mice (DEN(ctrl) HCCs).

181 ived experimental live attenuated monovalent DEN vaccines.

182 Moreover, DEN(N2ICD) HCCs exhibit increased Sox9 messenger RNA (mR

183 tudy, the use of a dopant enriched nitrogen (DEN)-gas combined with sheathless capillary electrophore

184 the chemical carcinogen diethyl nitrosamine (DEN) than wild-type animals.

185 umor cells in mice with diethyl nitrosamine (DEN)-initiated, Western alcohol diet-promoted liver tumo

186 oma after initiation by diethyl-nitrosamine (DEN).

187 We examined N-nitrosodiethylamine (DEN)-induced tumorigenesis in hepatic beta-catenin condi

188 , with more than 95% of the cells showing no DEN-2 antigen accumulation.

189 Notably, DEN-treated Hh-infected KO mice exhibited increased numb

190 el that is more relevant to DHF/DSS, a novel DEN strain, D2S10, was generated by alternately passagin

191 crucial for both early and late clearance of DEN infection in mice, and (iii) the IFN system plays a

192 y models, so we examined the contribution of DEN-1 to HIF stabilization.

193 Initial growth curves of DEN-2 virus 16681 were obtained in Vero cells incubated

194 The effect of DEN-gas on the repeatability and intermediate precision

195 dinal feature of DHF/DSS, the severe form of DEN infection, is increased vascular permeability.

196 mal care, but does decrease the frequency of DEN-induced cancer initiation.

197 may play a role in the immunopathogenesis of DEN hemorrhagic fever.

198 In mice given a single i.p. injection of DEN, AHR antagonized liver tumor formation and growth by

199 Knockdown of DEN-1 in human intestinal epithelial cells resulted in i

200 apoptotic defects developed in the livers of DEN-treated TRAIL-R-/- mice.

201 re identified at 32 weeks in the majority of DEN-treated mice from all three groups.

202 tion after PH, as well as the progression of DEN-induced tumors, providing evidence for a functional

203 ed hepatocyte proliferation and promotion of DEN-induced hepatic tumors secondary to aberrant c-Myc a

204 Although hepatocytes in nontumor regions of DEN-exposed livers were quiescent regardless of RB statu

205 for their ability to inhibit replication of DEN virus serotype 2 (DEN-2 virus) in mammalian cell cul

206 and characterized the cytokine responses of DEN virus-specific memory CD4+ T cells in PBMC of six vo

207 gnificantly increased the number and size of DEN-induced hepatic tumors.

208 ed in the livers of control and, more so, of DEN-exposed Ahr-/- mice.

209 ted responses seem to act at later stages of DEN disease by restricting viral replication in the peri

210 Disruption of TrxR1 in a marked subset of DEN-initiated cancer cells had no effect on their subseq

211 -PMO showed relatively little suppression of DEN-2 virus titer (0.1 and 0.9 log10, respectively).

212 tration of an antioxidant around the time of DEN exposure blocked prolonged JNK activation and compen

213 The use of DEN-gas opens new avenues for highly sensitive sheathles

214 he enhanced repeatability fosters the use of DEN-gas sheathless CE-ESI-MS in protein glycosylation an

215 Daily treatment of 6-month-old DEN-exposed beta-cat KO with PDGFRalpha inhibitor dramat

216 ogenesis and hepatocarcinogenesis in mice on DEN challenge by up-regulating several genes involved in

217 ed the influence of cellular growth state on DEN type 2 (DEN2) replication in mosquito and human cell

218 ngiocarcinoma, compared with mice given only DEN.

219 ollowing the first oxidation (i.e. of DMN or DEN to an aldehyde).

220 effect was observed for RNAs with globin or DEN 5' sequences, indicating no codependency between vir

221 In contrast, mice infected with the parental DEN strain developed paralysis at late times after infec

222 ce infected with D2S10, but not the parental DEN strain, significant levels of serum tumor necrosis f

223 mice with diethylnitrosamine/phenobarbital (DEN/PB), which induces formation of liver cancer, actual

224 l and seed oil extracts pre, during and post DEN administration improved liver functions, decreased t

225 At 25 weeks post-DEN injection, all LKO mice developed CK-19-positive hep

226 of the 5'SL and 3'CS compounds as potential DEN virus therapeutics is warranted.

227 way controls later viral burden and prevents DEN disease in mice.

228 trate that IFNR-dependent control of primary DEN infection involves both STAT1-dependent and STAT1-in

229 onoverlapping functions in resolving primary DEN infection.

230 -dependent immunity in resistance to primary DEN infection in mice.

231 1-independent responses in mice with primary DEN infection included the early activation of B and NK

232 inase-independent functions of RIPK1 promote DEN-induced hepatocarcinogenesis.

233 cts downstream of TNFR1 signaling to promote DEN-induced liver tumorigenesis.

234 These PPF/Al2O3/Pt DEN electrodes were completely stable under a variety of

235 The resulting Pt DEN films were electrocatalytically active for the oxyge

236 Four control rats did not receive DEN.

237 t to demonstrate the safety of a recombinant DEN virus tetravalent vaccine in a formal neurovirulence

238 r structures clarify the previously reported DEN MTase structure, suggest novel protein-cap interacti

239 y of the four related dengue virus serotypes DEN-1, -2, -3 and -4, which are transmitted to people by

240 rotein from all four Dengue virus serotypes (DEN-80E) formulated with ionizable cationic lipid nanopa

241 nificant advance in animal models for severe DEN disease, and it begins to provide mechanistic insigh

242 ay be one of several key mediators of severe DEN-induced disease in mice.

243 ced HCCs with constitutive Notch2 signaling (DEN(N2ICD) HCCs) exhibit a marked increase in size, prol

244 t to liver tumorigenesis induced by a single DEN injection, whose tumorigenesis was associated with m

245 and TV-3, possess properties of a successful DEN vaccine and can be considered for evaluation in clin

246 expression of GCIP in mouse liver suppressed DEN-induced hepatocarcinogenesis at an early stage of tu

247 of a small-animal model that mimics systemic DEN disease without neurovirulence has been an obstacle,

248 3 model provides a relevant platform to test DEN vaccines and antivirals.

249 ating that they are less differentiated than DEN(ctrl) HCCs.

250 We conclude that DEN-1 is a regulator of cullin neddylation and fine-tune

251 This report demonstrates that DEN replication and translation are not affected under c

252 The DEN 3' UTR increased mRNA stability, although this effec

253 The DEN 3' UTR thus has translational regulatory properties

254 at translational enhancement provided by the DEN 3' UTR is attributable to the cumulative contributio

255 studied increased similarly over time in the DEN group.

256 In the DEN-induced animal model and clinical hepato-carcinoma s

257 Afp(-) DRPs and Prom1(+) Afp(+) TICs in the DEN-WAD model.

258 try site but requires the interaction of the DEN 5' and 3' UTRs for activity, suggesting a novel stra

259 Furthermore, the structures of the DEN and YF proteins are essentially identical, indicatin

260 mentary to cCS1 present in the 5' end of the DEN polyprotein open reading frame.

261 ession of 5'- and 3'-terminal regions of the DEN serotype 2 genome by using luciferase reporter mRNAs

262 -shaped concavity observed at the tip of the DEN-2 sE trimer.

263 targeting the 3'-terminal nucleotides of the DEN-2 virus genome and a random-sequence P4-PMO showed r

264 One of the DEN-2-resistant cell lines, FB 9.1, was further characte

265 However, the means by which the DEN genome is translated effectively in the presence of

266 This DEN noncanonical translation is not mediated by an inter

267 ased tumor multiplicity in livers exposed to DEN.

268 eptibility of mice lacking the AEG-1 gene to DEN-induced hepatocarcinogenesis.

269 EGFR inhibitor erlotinib delivered prior to DEN-induced injury was sufficient to block compensatory

270 silencing as the mechanism of resistance to DEN-2 in transformed mosquito cells.

271 AEG-1-deficient mice displayed resistance to DEN-induced HCC and lung metastasis.

272 designed to express irRNA were resistant to DEN-2 challenge, with more than 95% of the cells showing

273 ocyte necrosis over apoptosis in response to DEN due to a deficiency in energy production.

274 udy the immune mechanisms in the response to DEN infection.

275 played normal tumor formation in response to DEN, demonstrating that RIPK1 deficiency decreases DEN-i

276 ta is critical for early immune responses to DEN infection, (ii) IFN-gamma-mediated immune responses

277 ix metalloproteinases were more sensitive to DEN induction in the absence of TGR5 signaling.

278 examined whether increased susceptibility to DEN-induced hepatocarcinogenesis in Ikkbeta(Deltahep) mi

279 a paradoxical increase in susceptibility to DEN-induced tumorigenesis.

280 ) T cells had no increased susceptibility to DEN; however, RAG mice (deficient in both B and T cells)

281 B and T cells) were partially susceptible to DEN infection.

282 Nlrp12(-/-) mice were highly susceptible to DEN-induced HCC with increased inflammation, hepatocyte

283 overexpression makes TG mice susceptible to DEN-induced HCC.

284 e lacking JNK1 were much less susceptible to DEN-induced hepatocarcinogenesis.

285 ese defects and reversed unresponsiveness to DEN-induced liver injury and malignant development.

286 ed to a tetravalent formulation of wild-type DEN viruses (T-wt) for replication in SCID mice transpla

287 el of toxin-induced hepatic neoplasia, using DEN and 3,3',5,5'-tetrachloro-1,4-bis(pyridyloxy)benzene

288 Dengue virus (DEN) and other flaviviruses, such as West Nile and yello

289 Dengue virus (DEN) causes dengue fever and dengue hemorrhagic fever/de

290 c RNAs of flaviviruses such as dengue virus (DEN) have a 5' m7GpppN cap like those of cellular mRNAs

291 Dengue virus (DEN) is the most prevalent cause of arthropod-borne vira

292 Dengue virus (DEN), a flavivirus, causes dengue fever and dengue hemor

293 n appropriate animal model for dengue virus (DEN), which causes dengue fever and dengue hemorrhagic f

294 mice and treated the resulting animals with DEN/Phenobarbital, an established protocol for liver car

295 e hepatobiliary cysts, which correlated with DEN-induced transcriptional activation of Cdc25a mediate

296 d to controls at 6 days after infection with DEN-2 virus.

297 similar values were found for CE-ESI-MS with DEN-gas.

298 for liver tumorigenesis in mice treated with DEN, and identifies an important role for ACC enzymes in

299 hepatitis in WT and KO mice with or without DEN that correlated with significant upregulation of Tnf

300 To construct chimeric YF/DEN viruses (ChimeriVax-DEN), the premembrane (prM) and