ライフサイエンスコーパス: DMN

1 x overlapping with the default-mode network (DMN).

2 onnectivity within the default mode network (DMN).

3 he core regions of the default mode network (DMN).

4 mans, are known as the default-mode network (DMN).

5 with tilting of networks balance toward the DMN).

6 tiple-demand (MD) and default mode networks (DMN).

7 anti-correlated to the default mode network (DMN).

8 deactivate the brain's default-mode network (DMN).

9 nges in the connectivity patterns in ECN and DMN.

10 pposed to information integration across the DMN.

11 he evolutionarily preserved functions of the DMN.

12 ts in spatial attention activated the monkey DMN.

13 onarily preserved defining properties of the DMN.

14 d during shifts, largely overlapped with the DMN.

15 but in short-distance connections within the DMN.

16 transient connectivity between SN, CEN, and DMN.

17 s-wide signaling defects in a key hub of the DMN.

18 physiology and pathophysiology of the human DMN.

19 ) connections involve regions of the SMN and DMN.

20 of T2DM on the biophysical integrity of the DMN.

21 between the anterior and posterior parts of DMN.

22 rmediate speed in the SN, and slowest in the DMN.

23 he restrosplenial cortex, a major hub of the DMN.

24 whereas L5 neurons project in and out of the DMN.

25 oncurrent decrease in FC and activity in the DMN.

26 r 3 as well as decreased connectivity in the DMN.

27 on of the anatomical correlates of the mouse DMN.

28 esentation of visual aesthetic appeal in the DMN.

29 o investigate structural connectivity of the DMN across spatial scales with cell-type resolution.

30 Crucially, we find increases in ongoing DMN activity after ripples, but not in other RSNs.

31 fMRI could be informative to detect residual DMN activity for those patients that remain relatively s

32 However, increased spontaneous DMN activity has also been reliably associated with stab

33 As DMN activity has also been reported in nonhuman species,

34 In multiple contexts, increased spontaneous DMN activity has been associated with self-reported epis

35 Rs-fMRI indicated relatively preserved DMN activity in a small subset of VS/UWS patients, two o

36 laminergic transmission and a suppression of DMN activity in favor of externally-directed attentional

37 We found no evidence for increased DMN activity in the naturalistic compared to artificial

38 models were used to disentangle distinctive DMN activity patterns that are more profoundly associate

39 The behavioral relevance of endogenous DMN activity remains elusive, despite an emerging litera

40 hat the cognitive processes that spontaneous DMN activity specifically reflects are only partially re

41 as 5-HT signaling favors the predominance of DMN activity, manifesting in distinct behavioral pattern

42 rease in SMN activity along with increase in DMN activity.

43 ocessing the detail of individual steps, and DMN adding representation of broad task context.SIGNIFIC

44 of regions in the FPN being merged into the DMN after meditation) and (2) led to instability in the

45 tentiveness to the specialization within the DMN allows future work to consider the nuances in sub-re

46 Neuroimaging studies have shown that the DMN also exists in non-human primates, suggesting that i

47 neus and right posterior cingulate cortex in DMN, among CD patients compared to HC.

48 Within the default mode network (DMN) an area of the dorsomedial prefrontal cortex (DMPFC

49 al organization of the Default Mode Network (DMN) - an important subnetwork within the brain associat

50 uency (VF) in both groups as well as RSFC in DMN and anxiety level in the CD group.

51 baseline functional connectivity within the DMN and baseline parasympathetic tone respectively, high

52 However, the correlations between ECN/DMN and behavioral scores in each group were not signifi

53 y and greater anticorrelation between SN and DMN and between SN and ECN compared with patients with u

54 associated with hypoconnectivity within the DMN and between the DMN and the frontoparietal network,

55 In the AD group the anterior DMN and CEN appeared to be additionally affected.

56 d stronger connectivity between areas of the DMN and EN during the creative task, and this difference

57 (DMN), and increased connection between the DMN and FPN.

58 e bringing together the functional posterior DMN and its anticorrelated counterpart.

59 emonstrate that the PCC is vulnerable in the DMN and may shed light on the molecular neurobiology of

60 d position of individual steps; however, the DMN and MD networks favor task identity and step-level i

61 work connectivity in two intrinsic networks [DMN and salience network (SAN)], and (iii) higher within

62 dividuals show increased connectivity in the DMN and salience when neocortical Tau levels are low, wh

63 ficantly associated with connectivity in the DMN and salience.

64 independent resting state data revealed that DMN and shift regions clustered conjointly, whereas regi

65 Core monkey DMN and shift-selective regions shared several functiona

66 e default mode network (DMN) and between the DMN and the central executive network (CEN) in 111 indiv

67 ls, LOD patients showed decreased FC between DMN and the cingulo-opercular network (CON), as well as

68 associated with the decreased FC between the DMN and the CON, which probably resulted from the demyel

69 oconnectivity within the DMN and between the DMN and the frontoparietal network, but not with brain a

70 ronto-parietal and somatomotor networks, the DMN and visual, limbic, auditory and ventral attention n

71 onnectivity within the default mode network (DMN) and between the DMN and the central executive netwo

72 ectivity in the dorsal default mode network (DMN) and executive control network (ECN).

73 ence suggests that the default-mode network (DMN) and fronto-pariatal network (FPN) play an important

74 integration within the Default Mode Network (DMN) and its role in self-perceived empathy.

75 ring activation of the default mode network (DMN) and parietal alpha networks.

76 y defined nodes of the default mode network (DMN) and the dorsal attention network (DAN).

77 circuitry such as the default mode network (DMN) and visual and attention networks.

78 actions between salience (SN), default mode (DMN), and central executive (CEN) networks-three brain s

79 ercular network (CON), default mode network (DMN), and frontoparietal network-are consistently implic

80 perconnectivity in the default mode network (DMN), and increased connection between the DMN and FPN.

81 ecutive network (CEN), default mode network (DMN), and salience network (SN).

82 ence network (SN), and default-mode network (DMN)-and in neurotransmitters signaling-such as dopamine

83 al connectivity of the default mode network (DMN); and (3) the interactions between indoor incense bu

84 ng-state functional connectivity of the CON, DMN, and frontoparietal network, as well as the other ne

85 neus and bilateral superior frontal gyrus of DMN, and right anterior insula of SN.

86 em posteriorly and the default-mode network (DMN) anteriorly.

87 an demonstrating small-world properties, the DMN appears to be organized according to principles of a

88 s and that genes with high expression in the DMN are involved in synapse and dendrite formation.

89 lated deactivations in default mode network (DMN) areas.

90 sion analysis, the integrity of the anterior DMN as measured with PET alone accurately differentiated

91 rontal cortex (PFC) in default mode network (DMN) associated with TD in healthy subjects that showed

92 Notably, the effect of the DMN atrophy occurred in early aMCI stage, while the effe

93 range structural connections (such as in the DMN) between dogs and humans is likely to provide us wit

94 a functional neuroimaging paradigm in which DMN brain activation in a resting condition was contrast

95 d, negative HFB coupling between the DAN and DMN (but not SN and DMN) is associated with greater sust

96 in key regions of the default mode network (DMN), but not the dorsal attention network.

97 y of TMS propagation patterns across DAN and DMN, but not with resting-state EEG dynamics.

98 ts suggest that, like the human DMN, the rat DMN can be partitioned into several subcomponents that m

99 ctivation of the human default mode network (DMN) can be measured with fMRI when subjects shift thoug

100 The topography of the default mode network (DMN) can be obtained with one of two different functiona

101 Path analyses indicated that decreased DMN-CEN-negative connectivity mediated a relationship be

102 tography supported the findings of decreased DMN-CEN-negative connectivity.

103 eased DMN connectivity, as well as decreased DMN-CEN-negative connectivity.

104 ases in connectivity reflect global or local DMN changes.

105 Selective optogenetic activation of DMN cholinergic neurons or electrical activation of the

106 particularly for genes of high-relevance for DMN circuitry.

107 The DMN-CON FC and the FA, RD of the fiber tracts were both

108 Patients with FO had higher within-DMN connectivity and greater anticorrelation between SN

109 the right precentral gyrus and decreases in DMN connectivity in the right inferior frontal gyrus and

110 on was found between hippocampal volumes and DMN connectivity in the right temporo-parietal junction

111 adolescence and young adulthood, and reduced DMN connectivity may reflect local changes within the ne

112 Crucially, the magnitude of the DMN connectivity reduction correlated with striatal D2/3

113 Decreased DMN connectivity was more strongly associated with incre

114 Decreased CON and DMN connectivity, as well as cinguloparietal (CPAR) netw

115 amilial risk for depression showed increased DMN connectivity, as well as decreased DMN-CEN-negative

116 ted an atypical connectivity profile lacking DMN connectivity, with increased dorsal anterior cingula

117 rivation and disorders are linked to reduced DMN connectivity.

118 evidence that PPD is associated with altered DMN connectivity; cortical GABA+/Cr concentrations are a

119 We find that the mouse DMN consists of preferentially interconnected cortical r

120 The default mode network (DMN) consists of several regions that selectively intera

121 holinergic neurons residing in the brainstem DMN control TNF production, revealing a role for brainst

122 al anatomical connections with the posterior DMN core regions (PPC and PCC), while the mPFC has weak

123 mPFC has weak connections with the posterior DMN core regions.

124 The existence of DMN correlates in other species, such as mice, challenge

125 of topological patterns between the FPN and DMN could predict conscious state more effectively than

126 tworks represented separate streams by which DMN couples with other canonical large-scale networks, i

127 Moreover, DMN coupling strength predicted memory of narrative segm

128 ll no functional imaging evidence supporting DMN deactivation and deconnection during high-demanding

129 search the patterns of Default Mode Network (DMN) deactivation in Obsessive Compulsive Disorder (OCD)

130 derscored the importance of FW increases and DMN degeneration in early stage of memory deficit.

131 , a key hub within the default mode network (DMN) displays amyloid and tau-containing neurofibrillary

132 er mindfulness meditation training increases DMN-dlPFC rsFC and whether these rsFC alterations prospe

133 These results indicate that postero-medial DMN down-regulation may not be specific to neurodegenera

134 and suppression of the default mode network (DMN) during executive functioning have been observed in

135 ing attenuation of the default mode network (DMN) during the first half of a 20-min scan (i.e., durin

136 tiple-demand (MD) and default mode networks (DMN)-during multistep task episodes.

137 er there were differences in three networks: DMN, ECN and anterior salience network connectivity, as

138 imaging, recently nearly all studies on the DMN employ functional connectivity in rs-fMRI.

139 ts had difficulties with the deactivation of DMN even when the non-rest condition includes the presen

140 ence suggests that the default mode network (DMN) exhibits antagonistic activity with dorsal attentio

141 tween NBR and functional connectivity of the DMN extracted from the same tb-fMRI scan; then, we demon

142 However, conventional DMN fabrication methods have several drawbacks.

143 hat will be faced in large-scale fill-finish DMN fabrication processes and demonstrating superior the

144 Our results relate endogenous DMN fluctuations to hippocampal ripples, thereby linking

145 where we observe a dramatic increase in the DMN fMRI signal following ripples, but not following oth

146 e courses sampled from independently defined DMN foci showed significant shift selectivity during the

147 brain networks [e.g., default mode network (DMN), fronto-parietal network (FPN), and sensory-motor n

148 ode network (DMN); specifically, between the DMN, fronto-parietal and somatomotor networks, the DMN a

149 n networks such as the default-mode network (DMN), frontoparietal network, and salience network, are

150 Taken together, we further delineate DMN function by demonstrating the relative strengths of

151 DMN function is characteristically impaired in major neu

152 Sleep and DMN function may be tightly linked during adolescence an

153 Of the various sites that partake in DMN function, the posterior cingulate cortex (PCC), temp

154 t associations with individual variations in DMN functional activity, intelligence, sociability, and

155 king memory load was associated with reduced DMN functional connectivity, which was itself associated

156 formance, task-induced default mode network (DMN) functional connectivity changes, and striatal D2/3R

157 Moreover, HAR and DMN genes show significant associations with individual

158 The ECN and DMN had regions (middle temporal gyrus and bilateral mid

159 The default mode network (DMN) has been defined in functional brain imaging studie

160 The default mode network (DMN) has been suggested to support a variety of self-ref

161 Activity patterns from the DMN, however, were predictive of aesthetic appeal across

162 posterior cingulate cortex (PCC), a central DMN hub region, was selectively compromised in T2DM, whe

163 egions involved in the default mode network (DMN), implicated in divergent thinking and generating no

164 ularity structure of the pain matrix and the DMN in any of our two independent cohorts.

165 attention centered on midline regions of the DMN in both MEG and fMRI, boosting confidence in a possi

166 re dynamic interactions between SN, CEN, and DMN in children, characterized by higher mean lifetimes

167 of cortex and indicate that the role of the DMN in cognition might arise from its position at one ex

168 oset differs markedly from the stereotypical DMN in humans.

169 ed organizational framework for studying the DMN in individual humans.

170 This might explain a breakdown of the DMN in many neurological diseases characterized by decli

171 ropsychiatric disorders, partitioning of the DMN in nonhuman species, which has previously not been r

172 ET data, only the integrity of the posterior DMN in patients with AD was reduced, whereas 3 remaining

173 ad greater connectivity with the rest of the DMN in PPD (peak voxel: MNI coordinates (2, 58, 32), p =

174 te predominantly within certain parts of the DMN in preclinical AD and already then affect brain conn

175 ed deficits in deactivation of the posterior DMN in the T1D group were correlated with an earlier age

176 al connectivity of the default mode network (DMN) in 54 amnestic mild cognitive impairment (aMCI) and

177 x (PCC) regions of the default mode network (DMN) in dogs.

178 ibution similar to the default mode network (DMN) in humans, consistent with earlier findings in youn

179 ss of fit (GOF) of the default mode network (DMN) in the drug group and decreased GOF in the placebo

180 rachloride (CCl(4)) and dimethylnitrosamine (DMN), in vitro human hepatic sinusoidal endothelial cell

181 fect, probably in association with the brain DMN, in a light-dependent manner and/or with help from t

182 T2DM, whereas the other nodal regions of the DMN, including the medial prefrontal cortex, lateral inf

183 fibrotic effect, FZHY ameliorated CCl(4) and DMN-induced sinusoidal capillarization, angiogenesis and

184 e FNE was found in the default-mode network (DMN) involved with spontaneous internal thoughts during

185 Furthermore, the DMN is activated as a sentinel, monitoring the environme

186 The DMN is activated during monitoring the external world fo

187 In humans, the DMN is marked by strong functional connectivity among th

188 Rs-fMRI of the DMN is sensitive to clinical severity.

189 How disease affects the DMN is unknown, but detailed anatomical descriptions cou

190 tures to broad mental categories), which the DMN is well positioned to support, and we make novel pre

191 The default mode network (DMN) is a complex dynamic network that is critical for u

192 olutionarily conserved default mode network (DMN) is a distributed set of brain regions coactivated d

193 ), we propose that the default mode network (DMN) is additionally important for constructing discrete

194 The default mode network (DMN) is associated with a wide range of brain functions.

195 ling between the DAN and DMN (but not SN and DMN) is associated with greater sustained attention perf

196 posterior part of the default-mode network (DMN) is down-regulated by both normal ageing and Alzheim

197 ains; for example, the Default-mode network (DMN) is engaged during internally oriented cognition.

198 The brain's default mode network (DMN) is highly active during wakeful rest when people ar

199 The default-mode network (DMN) is known to be dysfunctional, although correlation

200 The momentary configurations of DMN ISFC were highly replicable across groups.

201 As a population, DMN layer 2/3 (L2/3) neurons project almost exclusively

202 s unclear whether these subcomponents of the DMN make unique contributions to specific cognitive proc

203 na in neural physiology and suggest that the DMN may coordinate replay bursts in a manner that minimi

204 gs suggest that the changing topology of the DMN may play an important role in characterizing brain s

205 nt deactivation in two anterior nodes of the DMN (medial frontal and superior frontal) in the non-res

206 Thus, although both MD and DMN networks are sensitive to step-level and episode-lev

207 ines in the spleen, although the function of DMN neurons in regulating TNF release is not known.

208 tivity and structural connectivity among the DMN nodal regions are compromised in T2DM.

209 wed a typical pattern of connectivity across DMN nodes, as previously reported in depressed patients

210 ies (GeoPref ASD) is characterized by marked DMN-occipito-temporal cortex (OTC) hypoconnectivity.

211 r dynamic topological reconfiguration of the DMN occurs across different brain states, and whether th

212 onnectivity within the default mode network (DMN) of the brain while participants listened to sounds

213 assification approach, we tested whether the DMN or ventral occipitotemporal cortex (VOT) contains a

214 Increased DMN-OTC hypoconnectivity is also related to increased se

215 posterior node of the default mode network (DMN; p = 0.006).

216 cifically sleep irregularity - relate to the DMN, particularly among adolescents and young adults.

217 Immunization using low dose TIV-loaded DMN patches induced significantly higher antibody respon

218 Dissolvable microneedle (DMN) patches for immunization have multiple benefits, in

219 as observed within the default-mode network (DMN) post-treatment.

220 4 major NCNs: anterior default-mode network (DMN), posterior DMN, salience network, and right central

221 Anticorrelation of SN-DMN predicted outcomes with higher accuracy than fluid-a

222 nd position of individual steps, however the DMN preferentially represented task identity while the M

223 gnitive load could arise from disruptions of DMN processes, including social cognition.

224 iding in the brainstem dorsal motor nucleus (DMN) project in the vagus nerve to communicate with the

225 connections within the default mode network (DMN; prominent during introspective thought) and connect

226 ng an evolutionary preserved function of the DMN, putatively improving translational relevance of pre

227 Does the default mode network (DMN) reconfigure to encode information about the changin

228 t the NBR and functional connectivity of the DMN reflect two separate but overlapping neurophysiologi

229 In the retrosplenial cortex, a core DMN region, we identify two L5 projection types differen

230 th memory performance [4, 5]-particularly in DMN regions [6-8].

231 hen, we demonstrate that the NBR in putative DMN regions can be significantly altered without causing

232 e changes in cognitive context would recruit DMN regions in female and male nonhuman primates.

233 sity and the functional connectivity between DMN regions, and provides anatomical evidence to support

234 h length (increased network connectivity) in DMN regions, particularly the right and left lateral par

235 neurons project almost exclusively to other DMN regions, whereas L5 neurons project in and out of th

236 t, plus a marked offset response specific to DMN regions.

237 tive shifting in primates generally recruits DMN regions.

238 DMN-related and DHT-affected genes (e.g., MEF2C) are inv

239 prominently including many areas outside the DMN, relative to both young adults (Y) and aged rats wit

240 eversed effects (decreased ECN and increased DMN, respectively).

241 editation may increase default mode network (DMN) resting-state functional connectivity (rsFC) with r

242 in the human brain, and most pronounced the DMN, runs parallel with high expression of human-acceler

243 Mechanistic support for the DMN's role in memory consolidation might come from inves

244 association networks [default-mode network (DMN), salience network (SAL), dorsal attention network,

245 tention network (DAN), default-mode network (DMN), salience network (SN), and executive control netwo

246 terior default-mode network (DMN), posterior DMN, salience network, and right central executive netwo

247 Notably, models trained on within-DMN sFC and eFC performed better than models trained on

248 Moreover, the FPCN and DMN showed significantly elevated coupling with each oth

249 th increased behavioral variability, highest DMN signal levels were best explained by intense mind-wa

250 self-referential processing supported by the DMN.SIGNIFICANCE STATEMENT Modularity, an index of the d

251 f the medial prefrontal cortex (mPFC) to the DMN spatial mode.

252 widespread responses at episode onset, plus DMN-specific offset responses.

253 onnectivity within the default mode network (DMN); specifically, between the DMN, fronto-parietal and

254 ls revealed that DOL significantly predicted DMN strength in these regions.

255 At this scale, nine DMN subnetworks exhibited topographical similarity acros

256 Some DMN subnetworks matched known features of brain organiza

257 stent within known DMN subsystems and across DMN subregions.

258 at highly correspond to the cortical midline DMN subsystem.

259 ionships were highly consistent within known DMN subsystems and across DMN subregions.

260 anatomical evidence to support the detected DMN subsystems.

261 nectivity between social brain default mode (DMN) subsystems in adolescent males, but has no effect i

262 nalysis was performed on fMRI data to assess DMN suppression during Stroop performance.

263 moderated-mediation analyses indicated that DMN suppression was associated with Stroop performance i

264 d with improved task performance and greater DMN suppression.

265 ciated with improved performance and greater DMN suppression.

266 rojection types differentiated by in- or out-DMN targets, laminar position, and gene expression.

267 p with key hubs of the default mode network (DMN) that become compromised by amyloid pathology years

268 Furthermore, we present evidence that in the DMN, the NBR is more closely related to task performance

269 , these results suggest that, like the human DMN, the rat DMN can be partitioned into several subcomp

270 We found that DMN topology changes over time and those different patte

271 e investigated both nodal and global dynamic DMN-topology metrics across different brain states.

272 The DMN-TPJ disconnection is instead linked to the volumetri

273 network (FPCN) and the default mode network (DMN), two networks that do not strongly interact with on

274 o offset diabetes-related impairments in the DMN, ultimately facilitating cognitive and behavioral pe

275 structural changes of default mode network (DMN) underlying the cognitive impairment in Late-onset d

276 enous fluctuations in specific RSNs-like the DMN-unitarily.

277 e sought to identify constituents of the rat DMN using resting-state functional MRI (rs-fMRI) and dif

278 High pretrial activity within the DMN was associated with a greater increase in shift tria

279 RI) and the relationship between the SRI and DMN was examined using graph theory analysis.

280 no significant connection of SN with CEN and DMN was found in PTSD patients.

281 In fMRI data, the integrity of the posterior DMN was found to be significantly reduced in both patien

282 While the DMN was initially defined by consistent task-based decre

283 e found lower functional connectivity in the DMN was related to worse memory across AD continuum.

284 The brain default mode network (DMN) was activated, gauged by increases in the LF-band (

285 tand the temporally changing topology of the DMN, we investigated both nodal and global dynamic DMN-t

286 re severe impairments in deactivation of the DMN were associated with greater increases in hyperactiv

287 measures and functional connectivity of the DMN were recorded at baseline.

288 activity and functional coupling within the DMN when listening to naturalistic sounds.

289 cognitive function and default mode network (DMN), which has been implicated in affective function.

290 on associated with the default mode network (DMN), which is more active during rest than under active

291 recuneus) and global connectivity within the DMN, which are associated with better performance.

292 ly distinct interactions between the FPN and DMN, which may mediate conscious state.

293 al mapping reveal cholinergic neurons in the DMN, which project to the celiac-superior mesenteric gan

294 ection with the LN and anti-correlation with DMN while the ventral seed had a stronger connection wit

295 meditation training functionally couples the DMN with a region known to be important in top-down exec

296 ncreased RD of these fiber tracts connecting DMN with CON were found in LOD patient.

297 Examining the DMN with the cGERGM, we show that, rather than demonstra

298 thesized by conjugating diaminomaleonitrile (DMN) with benzothiazole unit, and characterized by singl

299 to external tasks and lateral regions of the DMN within DLPFC, as well as less cortical grey matter i

300 demanding cognitive shifts could recruit the DMN, yet it is unknown whether this holds for nonhuman s