ライフサイエンスコーパス: DNA adduct

1 and non-physiological barriers (for example, DNA adducts).

2 lead to the persistence of this detrimental DNA adduct.

3 l II) stalled at a monofunctional pyriplatin-DNA adduct.

4 rom an initially formed, unstable colibactin-DNA adduct.

5 e is located to the 5' side of the cisplatin-DNA adduct.

6 ounteract its activity along the repair of a DNA adduct.

7 tection of a colibactin-derived cross-linked DNA adduct.

8 halan) activity, as measured by formation of DNA adducts.

9 ll death by forming intrastrand dinucleotide DNA adducts.

10 ull scan, was included for detecting unknown DNA adducts.

11 he development of technologies for detecting DNA adducts.

12 s influence the hPol eta-catalyzed bypass of DNA adducts.

13 revelation of the biological consequences of DNA adducts.

14 fter metabolic activation, with DNA to yield DNA adducts.

15 derstanding the human health consequences of DNA adducts.

16 nd repair, it is necessary to be able to map DNA adducts.

17 for the screening for both known and unknown DNA adducts.

18 in a manner distinct from that of cisplatin-DNA adducts.

19 e content, lipid peroxidation, and oxidative DNA adducts.

20 urther includes, among others, various bulky DNA adducts.

21 bles quantitative immunodetection of protein-DNA adducts.

22 by promoting accumulation of topoisomerase 1-DNA adducts.

23 of CP-TGGA compared to OX-TGGA and other Pt-DNA adducts.

24 dG residues in DNA to form aristolactam (AL)-DNA adducts.

25 ly effective approach for detection of bulky DNA adducts.

26 toxicity vs. DNA of chemicals forming stable DNA adducts.

27 amino group of purine bases generating bulky DNA adducts.

28 ctive oxygen species and by the formation of DNA adducts.

29 UvrABC incisions of the bulky aminofluorene DNA adducts.

30 PC-RAD23B, failed to specifically bind to AL-DNA adducts.

31 sociated with the presence of detectable PAH-DNA adducts.

32 id reacts with DNA to form aristolactam (AL)-DNA adducts.

33 mainly responsible for removal of pyriplatin-DNA adducts.

34 atile mechanism to repair a variety of bulky DNA adducts.

35 ct to demonstrate the applicability to other DNA adducts.

36 dependent and sequence-specific formation of DNA adducts.

37 enal, which cause the formation of mutagenic DNA adducts.

38 n of persistent imidazole ring-opened AFB(1)-DNA adducts.

39 ibility to mutations from tobacco carcinogen DNA adducts.

40 ied DNA and, more frequently, when bypassing DNA adducts.

41 que DNA repair pathway that removes platinum-DNA adducts.

42 and can react with DNA in the films to form DNA adducts.

43 ing algorithm can be used to detect putative DNA adducts.

44 then can react with DNA to form carcinogenic DNA adducts.

45 tes to the accumulative pattern of cisplatin-DNA adducts.

46 o study the formation of endo- and exogenous DNA adducts.

47 DNA-distorting lesions, including cisplatin-DNA adducts.

48 The DNA adduct 1,N(2)-etheno-2'-deoxyguanosine, with a large

49 pecific repair of lipid peroxidation-induced DNA adduct, 1, N(6)-ethenoadenine (epsilonA).

50 uniquely blocks excision repair of cisplatin-DNA adducts, 1,2-intrastrand cross-links, to potentiate

51 DNA templates modified with the carcinogenic DNA adducts, 2-aminofluoene (AF) or N-acetyl-2-aminofluo

52 cherichia coli AlkB dioxygenase of exocyclic DNA adducts 3,N(4)-ethenocytosine, 1,N(6)-ethenoadenine,

53 cts with DNA to form the aristolactam (AL-I)-DNA adduct 7-(deoxyadenosin-N(6)-yl) aristolactam I (dA-

54 to chemicals can result in the formation of DNA adducts, a molecular initiating event in genotoxin-i

55 o identify, locate, and quantify a mutagenic DNA adduct, advancing tools for linking DNA alkylation t

56 , the mutagenic property of the primary AFB1-DNA adduct, AFB1-N7-Gua, in mammalian cells has not been

57 BaP forms covalent DNA adducts after metabolic activation and induces mutat

58 The preferential formation of AFB(1)-induced DNA adducts along the cII transgene was almost exclusive

59 PhIP-DNA adducts also were recovered quantitatively from form

60 The applications of mass spectrometry-based DNA adduct analysis for predicting the therapeutic outco

61 lopment of MS techniques on these fronts for DNA adduct analysis.

62 number of interface contacts between the Pt-DNA adduct and HMGB1a.

63 AH exposure, resulting in both increased PAH-DNA adducts and altered DNA methylation.

64 cleotide excision repair mechanism to repair DNA adducts and are sensitive to alkylating agents.

65 the repair of topoisomerase type II (Top II) DNA adducts and associated DSBs.

66 These small molecules also act as DNA adducts and coordinate with their DNA hosts.

67 Immunohistochemistry of LPAM-DNA adducts and damage was performed as surrogates for L

68 (in a subset), and quantified benzo[a]pyrene-DNA adducts and genomic DNA methylation in cord blood DN

69 our research on the biological processing of DNA adducts and how this may impact the observed product

70 s corresponding to metabolites known to form DNA adducts and initiate lung cancer (2.35 A) or with tw

71 teins have been demonstrated to bind to CDDP-DNA adducts and initiate MMR protein-dependent cell deat

72 s involved in the recognition of these bulky DNA adducts and initiates the global genomic nucleotide

73 nly be formed through dissociation of duplex DNA adducts and not by direct interaction of PBDs with s

74 escribe the first structure of levuglandinyl-DNA adducts and provide the tools with which to evaluate

75 eta is essential for processing AFB1-induced DNA adducts and that, in its absence, cells do not have

76 A1 are required for both the removal of Top2-DNA adducts and the subsequent resection of Top2-adducte

77 es between RC-DNA and cellular topoisomerase-DNA adducts and their known repair by tyrosyl-DNA-phosph

78 eptor (AR) ligand, is known to form covalent DNA adducts and to induce apoptosis potently in AR-posit

79 Using AL-DNA adducts and TP53 mutation spectra as biomarkers, we

80 t process that leads to formation of the PBD-DNA adduct, and have allowed the preference of 3a for IC

81 ates consistent with measured soil PAHs, PAH-DNA adducts, and CO readings.

82 pol delta L606K is impaired in the bypass of DNA adducts, and the homologous variant in mouse embryon

83 chniques for the quantitative measurement of DNA adducts, and the use of LC-MS along with molecular b

84 on mechanism by MXY, which leads to covalent-DNA adducts; and (iv) the redox properties of the adduct

85 DNA adducts are a measure of internal exposure to genoto

86 Etheno DNA adducts are a prevalent type of DNA damage caused by

87 For nuclear genomes, cisplatin-DNA adducts are enriched within promoters and regions ha

88 These PAH-DNA adducts are established markers of cancer risk.

89 Bulky DNA adducts are important replication-blocking lesions,

90 Their DNA adducts are known to exist in an equilibrium between

91 research has revealed that pyrimidopurinone DNA adducts are subject to enzymatic oxidation in vitro

92 racterization of reactions in which covalent DNA adducts are transient intermediates.

93 However, the utility of a single DNA adduct as a biomarker in risk assessment is debatabl

94 However, the employment of DNA adducts as biomarkers in human studies is often rest

95 Using mainly BPDE-DNA adducts as model lesions, we show that HR induced by

96 h form the same monofunctional-intercalative DNA adducts as the parent compounds, as demonstrated in

97 tabolites, estrogen conjugates, and estrogen-DNA adducts as well as exogenous steroid derivatives.

98 s well suited for processing other localized DNA adducts as well.

99 We identify that mutations linked to DNA adducts associated with tobacco smoke exposure are p

100 Control cells repaired 78% of platinum-DNA adducts at 12 h, compared with 33% repair in cells p

101 is specifically required for the removal of DNA adducts at sites of DNA breaks.

102 cation-dependent removal of Topo-isomerase I-DNA adducts at the step of strand cleavage, leading to s

103 Second, targeted detection of anticipated DNA adducts based on the reactivity of the DNA alkylatin

104 ues can serve as biospecimens for carcinogen DNA adduct biomarker research.

105 Because cisplatin-DNA adducts block RNA polymerase II unless removed by tr

106 tion of benzo[a]pyrene-7,8-diol 9,10-epoxide-DNA adduct (BPDE-DNA), which is a metabolite of benzo[a]

107 that Y-family DNA polymerases tolerate large DNA adducts, but a substantial decrease in catalytic eff

108 says have been used for the analysis of many DNA adducts, but problems are frequently encountered in

109 tential basis for site-specific detection of DNA adducts, but the availability of effective artificia

110 a efficiently replicates past a minor groove DNA adduct by positioning the adducted base in the syn c

111 oindels are 'scars' from the bypass of large DNA adducts by a translesional polymerase, e.g. the 'Tar

112 artificial nucleotides incorporated opposite DNA adducts by engineered DNA polymerases offers a poten

113 ecent studies have demonstrated that various DNA adducts can be detected in human tissues and fluids

114 The DNA adducts can be used as biomarkers for studies of AA

115 Interstrand cross-linked (ICL) dG-MC-dG-DNA adducts can prevent strand separation.

116 le DNA damage such as benzo[a]pyrene-induced DNA adducts, can be converted to a double-stranded DNA (

117 This new theme in PAH DE-DNA adduct conformation differs from (1) the classical i

118 dent increase in 8-hydroxy-2'-deoxyguanosine DNA adducts consistent with cumulative ROS damage.

119 measures relative rates of DNA oxidation and DNA adduct damage.

120 a-OHPdG) is an endogenously formed mutagenic DNA adduct derived from lipid peroxidation.

121 In vivo, the predominant DNA adduct derived from metabolically activated benzo[a]

122 N(2)-yl)-1-aminopyrene (dG(1,8)), one of the DNA adducts derived from 1-NP, can be bypassed by Sulfol

123 We established a method to measure DNA adducts derived from 16 ubiquitous genotoxicants and

124 DNA adducts derived from AA-I and AA-II have been isolat

125 DNA adducts derived from carcinogenic polycyclic aromati

126 e used to simultaneously screen for multiple DNA adducts derived from different classes of carcinogen

127 NA adducts from archived tissue by measuring DNA adducts derived from four other classes of human car

128 ligned 10S (+)-trans-anti-B[a]P-N(2)-dG (G*) DNA adduct, derived from the environmental carcinogen be

129 Wide-SIM/MS(2) successfully detected DNA adducts, derived from chemicals in the diet and trad

130 he relative stability of single-stranded PBD/DNA adducts despite a complete loss of minor groove stru

131 igarette smoking increases oxidative damage, DNA adducts, DNA strand breaks, chromosomal aberrations,

132 is432Arg forms an observable and unique Tdp1-DNA adduct during catalysis.

133 n crosslinks (DPCs), including Topoisomerase-DNA adducts, during DNA replication.

134 ) and Csb(-/-) mice fail to remove cisplatin-DNA adducts efficiently in vitro; and unlike Xpc(-/-) mi

135 ication forks initially encountering a bulky DNA adduct exhibit a dual nature of stalling: a checkpoi

136 first quantitative analysis of DEB specific DNA adducts following low ppm and subppm exposure to BD.

137 tion of a covalent phosphoramidate histidine-DNA adduct for cell-to-cell transfer.

138 s, NO-aspirin 2 inhibited [3H]benzo[a]pyrene-DNA adduct formation and DNA damage elicited by TCDD or

139 base for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissue

140 exposures to aflatoxin (AFB1) and subsequent DNA adduct formation being a significant driver.

141 xogenous FA causes only a modest increase in DNA adduct formation compared with the amount of adducts

142 The method can be applied to compare AA-DNA adduct formation in cells and tissues.

143 ar uptake, aqueous reactivity, and extent of DNA adduct formation in the A2780 ovarian carcinoma cell

144 with which to evaluate the potential for LG-DNA adduct formation in vivo.

145 Experimental evidence suggests that PAH-DNA adduct formation may preferentially target methylate

146 n for 11beta, which supplements conventional DNA adduct formation to promote cancer cell death.

147 ytotoxicity, cDDP cellular accumulation, and DNA adduct formation was compared in the CLDN3- and CLDN

148 brane potential and terminating in oxidative DNA adduct formation, DNA strand breakage, and cell deat

149 Despite DNA adduct formation, localized fork stalling was abroga

150 y via TOP2-independent mechanisms, including DNA adduct formation, redox activity, and lipid peroxida

151 abricated to measure reactive metabolite and DNA-adduct formation rates relevant to genotoxicity scre

152 hydroperoxide was responsible for endogenous DNA-adduct formation.

153 may be the case with ethano-adenine (EA), a DNA adduct formed by an important anticancer drug, BCNU,

154 8-Halogenated guanine (haloG), a major DNA adduct formed by reactive halogen species during inf

155 inobiphenyl (dG-C8-ABP), the predominant ABP-DNA adduct formed in bladder cells and tissues, was mark

156 s genome integrity by hydrolyzing 5'-tyrosyl DNA adducts formed by abortive topoisomerase II (Top2) c

157 The DNA adducts formed by the 1-NP metabolites stall replica

158 ance by catalyzing the replicative bypass of DNA adducts formed by the widely used chemotherapeutic a

159 known nucleotide composition and analysis of DNA adducts formed from chemically diverse AAs in vitro.

160 re exceptionally bulky, structurally diverse DNA adducts formed in cells upon exposure to endogenous

161 the efficacy of our method for retrieval of DNA adducts from archived tissue by measuring DNA adduct

162 latin, consistent with shielding of platinum-DNA adducts from excision repair.

163 Preferential repair of bulky DNA adducts from the transcribed genes via nucleotide ex

164 ite the chemically different nature of their DNA adducts, further supporting a role for monofunctiona

165 is the most common method for biomonitoring DNA adducts, generally targeting single exposures and me

166 However, the genomic pattern of cisplatin-DNA adducts has remained unknown owing to the lack of a

167 However, no exogenous formaldehyde-induced DNA adducts have been detected in animals after inhalati

168 These DNA adducts have been shown to block DNA replication by

169 rcinogens derived from cooked meats, such as DNA adducts, have not been identified in human samples t

170 t increase in the 4-oxo-2(E)-nonenal-derived DNA-adduct, heptanone-etheno-2'-deoxyguanosine (Hepsilon

171 , the chemical constitution of the retrieved DNA adducts hint at a direct link with an increase in NO

172 at a site-specific monofunctional pyriplatin-DNA adduct in the active site.

173 NA helicases are inhibited by bulky covalent DNA adducts in a strand-specific manner.

174 It can be used to detect topoisomerase 1-DNA adducts in as little as 60 ng of DNA, corresponding

175 unknown PR104A-induced mono and cross-linked DNA adducts in biological samples.

176 MGMT homeostasis and DNA repair of alkylated DNA adducts in cells.

177 s and accurate measurements of the levels of DNA adducts in cellular and tissue DNA constitute the fi

178 Studies showed that levels of ethylated DNA adducts in certain tissues and urine are higher in s

179 Finally, we detected both DNA adducts in colon tissue of a mouse orally treated wi

180 that a broad spectrum of combustion-related DNA adducts in cord blood was associated with attention

181 TDP1 removes covalent 3'DNA adducts in DNA single-strand break repair.

182 Top2a-DNA adducts in human cells, and gyrase-DNA adducts in Escherichia coli.

183 f reactive estrogen metabolites and estrogen-DNA adducts in female but not male mice.

184 alkylation to mutagenesis and for detecting DNA adducts in genes as potential diagnostic biomarkers

185 s of binding of PARP-1 to different platinum-DNA adducts in greater detail, biotinylated DNA probes c

186 ts the interpretation that formation of AFB1-DNA adducts in hepatocytes seeds a population of mutatio

187 ed RADAR assay can detect Top1-DNA and Top2a-DNA adducts in human cells, and gyrase-DNA adducts in Es

188 potentially carcinogenic N(2)-deoxyguanosine DNA adducts in human cells.

189 antification of glyoxal-derived cross-linked DNA adducts in human leukocyte DNA and their association

190 used for the simultaneous analysis of the 16 DNA adducts in human lung biopsy specimens.

191 -seq) to study nucleotide excision repair of DNA adducts in humans, mice, Arabidopsis thaliana, yeast

192 here are no previous reports of formaldehyde-DNA adducts in humans.

193 019 causes interstrand cross-links and bulky DNA adducts in mammalian cell lines.

194 rescence-based assay for the detection of AA-DNA adducts in multiple samples.

195 ns between a DNA polymerase and carcinogenic DNA adducts in real-time by single-molecule fluorescence

196 m (after metabolic activation) pro-mutagenic DNA adducts in renal tissue.

197 this neuropathy correlates with formation of DNA adducts in sensory neurons, growing evidence suggest

198 Second, we demonstrated both DNA adducts in target cells (Salmonella typhimurium TA10

199 cally inhibits repair of the major cisplatin-DNA adducts in TGCT cells by using the human TGCT excisi

200 chemicals, by simultaneously detecting their DNA adducts in the genome; some of which may induce canc

201 Several anticancer agents that form DNA adducts in the minor groove interfere with DNA repli

202 Immunodotblot determination of DNA adducts in the overall genome of AFB(1)-exposed cell

203 elevated blood formaldehyde and formaldehyde-DNA adducts in tissues.

204 and G, to form premutagenic cyclic covalent DNA adducts in vitro and in vivo.

205 od crops (e.g., broccoli and cabbage), forms DNA adducts in vitro and is mutagenic to bacterial and m

206 sible for the generation of the HepsilondGuo DNA-adduct in CESS cells.

207 n was associated with increased formation of DNA adducts, increased apoptosis, and intracellular sign

208 To identify the mechanisms by which bulky DNA adducts induce damage signaling, we developed an in

209 ide-based DNMT inhibitors that form covalent DNA adducts induce p53R2 expression.

210 e genome for 8-oxoguanine, a major mutagenic DNA adduct induced by reactive oxygen species, and catal

211 nd O(4)-pyridyloxobutylthymidine, which is a DNA adduct induced by tobacco-specific N-nitrosamines, i

212 loped to investigate anticipated and unknown DNA adducts induced by DNA alkylating agents in biologic

213 s mismatched nucleotides but also recognizes DNA adducts induced by DNA-damaging agents, and triggers

214 cted to be a powerful tool for screening for DNA adducts induced by endogenous or exogenous exposures

215 forms of DNA damage, including low-abundance DNA adducts induced by reactions with electrophiles.

216 ed the processing of topoisomerase II (Top2)-DNA adducts induced by treatment with the chemotherapeut

217 artificial nucleotides that insert opposite DNA adducts is extremely limited, and furthermore, there

218 ), which covalently bind to DNA to form drug-DNA adducts, is linked to their recognition by repair pr

219 n its catalytic intermediate-a covalent TOP1-DNA adduct known as a TOP1 cleavage complex (TOP1cc)-is

220 ificantly faster and produced 50-fold higher DNA adduct levels than P2-6S.

221 net accumulation of platinum (Pt) and the Pt-DNA adduct levels were reduced in CLDN3KD and CLDN4KD ce

222 ould significantly advance studies regarding DNA adduct levels, which are extremely difficult to dete

223 In mammalian cells, bulky DNA adducts located in the template but not the coding s

224 and quantification of both known and unknown DNA adducts, mass spectrometry (MS) is deemed to be the

225 If not repaired, DNA adducts may compromise cellular functions by blockin

226 to retrospectively analyze FFPE tissues for DNA adducts may provide clues to the origin of human can

227 Cisplatin kills cells by forming cisplatin-DNA adducts, most commonly the Pt-d(GpG) diadduct.

228 For example, protein-DNA adducts must be removed to allow repair by either no

229 e from abasic sites and ribonucleotides, the DNA adduct N (7)-methyl deoxyguanosine (N(7) -CH(3) dG)

230 ss spectrometry to quantify the formaldehyde-DNA adduct N(6)-hydroxymethyldeoxyadenosine (N(6)-HOMe-d

231 dA in a DNA duplex, the prototype arylamine-DNA adduct [N-(2'-deoxyguanosin-yl)-7-fluoro-2-aminofluo

232 slesion DNA synthesis past the pro-mutagenic DNA adduct O(6)-benzylguanine (O(6)-BnG).

233 nucleotide has been demonstrated for a model DNA adduct O(6)-benzylguanine by a DNA polymerase.

234 ly higher concentrations of the NOC-specific DNA adduct O(6)-carboxy-methylguanine when pork underwen

235 Indeed, the toxic and mutagenic DNA adduct O(6)-carboxymethylguanine (O(6)-CMG) is frequ

236 Among the ethylated DNA adducts, O(2)-ethylthymidine (O(2)-edT) and O(4)-eth

237 The DNA adduct of PhIP, N-(deoxyguanosin-8-yl)-PhIP (dG-C8-P

238 However, the DNA adducts of 1 are removed from repair systems with lo

239 Recently, our laboratory reported that DNA adducts of aristolochic acid, a carcinogenic compone

240 We report here that DNA adducts of aristolochic acids (AAs) can be measured

241 In this study, DNA adducts of biological relevance, O(6)-methylguanine

242 ve nano-LC-Orbitrap MS (n) method to measure DNA adducts of several carcinogens originating from well

243 an hepatocytes treated with 4-ABP, and three DNA adducts of the cooked-meat carcinogen 2-amino-3,8-di

244 Five DNA adducts of the tobacco carcinogen 4-aminobiphenyl (4

245 results indicate that structurally different DNA adducts of these platinum complexes exhibit a differ

246 e duplexes containing kappaB site damaged by DNA adducts of three platinum complexes.

247 cular epidemiologic studies, measurements of DNA adducts often are precluded by the unavailability of

248 Cells defective in repairing (6-4) Py:Py DNA adducts or processing DNA crosslinks are extremely s

249 dihydro-2'-deoxyguanosine (oxoG) is a common DNA adduct produced by the oxidation of DNA by reactive

250 ne (N(2),3-epsilonG) is one of the exocyclic DNA adducts produced by endogenous processes (e.g. lipid

251 reactive oxygen species or recognize damaged DNA adducts promote infection, suggesting that H. pylori

252 To our knowledge, this is the most sensitive DNA adduct quantitation method yet reported, exceeding t

253 This new 'RADAR' (rapid approach to DNA adduct recovery) assay accelerates processing time 4

254 DNA adducts reflect the internal exposure to genotoxican

255 Platinum-DNA adduct repair was assessed by atomic absorbance spec

256 , and that Gli1 strongly influences platinum-DNA adduct repair, and cellular sensitivity to cisplatin

257 DNA adducts represent internal dosimeters to measure exp

258 s tested and optimized using a mixture of 18 DNA adducts representing a range of biologically relevan

259 Replicative bypass of cisplatin DNA adducts requires the cooperative actions of at least

260 These advancements in the technology of DNA adduct retrieval from FFPE tissue clear the way for

261 rized herein as a basis for potential future DNA adduct sequencing technologies.

262 g pregnancy as well as by the measurement of DNA adducts specific to benzo[a]pyrene (BaP), a represen

263 t with nucleobases to give carboxymethylated DNA adducts such as N3-carboxymethylthymidine (N3-CMdT)

264 he main pathway used for the repair of bulky DNA adducts such as those caused by UV light exposure an

265 lein reacts with DNA bases forming exocyclic DNA adducts, such as gamma-hydroxy-1,N(2)-propano-2'-deo

266 esterase I (Tdp1) catalyzes the repair of 3'-DNA adducts, such as the 3'-phosphotyrosyl linkage of DN

267 mokers in levels of a leukocyte formaldehyde-DNA adduct, suggesting a potentially important and previ

268 merases are more efficient at bypass of many DNA adducts than replicative polymerases.

269 thylguanine (O(6)-MeG) is a highly mutagenic DNA adduct that forms in human genomic DNA upon reaction

270 is then degraded on DNA, yielding a peptide-DNA adduct that is bypassed by CMG.

271 urfuryl-deoxyguanosine (fdG) is carcinogenic DNA adduct that originates from furfuryl alcohol.

272 minofluorene (NA-AAF), which generates bulky DNA adducts that block RNA polymerase movement.

273 h a stable A.T base pair to create alkylated DNA adducts that can be removed by alkyladenine DNA glyc

274 ncodes an enzyme that hydrolyzes 5'-tyrosine-DNA adducts that mimic abortive Top2cc.

275 NA polymerases are unable to synthesize past DNA adducts that result from diverse chemicals, reactive

276 This method is based on the RADAR assay for DNA adducts that we previously developed, but incorporat

277 to create vectors containing a site-specific DNA adduct, the mutagenic potential was determined in pr

278 direct repair of the main TMZ-induced toxic DNA adduct, the O6-Methylguanine lesion.

279 Binary Cr-DNA adducts, the most abundant form of Cr-DNA damage, we

280 It forms DNA adducts, thereby activating poly(ADP-ribose) polymer

281 : a nucleophilic His (His(nuc)) that attacks DNA adducts to form a covalent 3'-phosphohistidyl interm

282 the polycyclic aromatic hydrocarbon-derived DNA adducts (+)-trans-anti-B[a]P-N(6)-dA, which is subje

283 The study of DNA adduct types and levels in human tissue therefore of

284 he DNA adductome; the levels of 22 different DNA adduct types significantly increased upon the consum

285 to occluded DNA ends by removing Ku or other DNA adducts via an Mre11-dependent nucleolytic reaction.

286 ase D superfamily that hydrolyzes 3'-phospho-DNA adducts via two conserved catalytic histidines-one a

287 ial nucleotide opposite an O(6)-alkylguanine DNA adduct was verified using a novel 2',3'-dideoxy deri

288 o studies demonstrating the formation of MMC-DNA adducts, we chose to investigate alternative nucleic

289 d3-related (ATR) is also stimulated by bulky DNA adducts, we conclude that a common biochemical mecha

290 (deoxyguanosin-8-yl)-AalphaC (dG-C8-AalphaC) DNA adducts were formed in hepatocytes.

291 AL-DNA adducts were present in the renal cortex of 83% of p

292 chemicals to DNA results in the formation of DNA adducts which are reflective of exposure of the huma

293 multaneous mass spectrometric analyses of 16 DNA adducts, which can be easily extended by adducts for

294 lymerases discriminate between CP- and OX-GG DNA adducts, which could partly account for differences

295 l cellular defense system against carcinogen-DNA adducts, which, if not repaired, can initiate cancer

296 Quantification of oxidative DNA adducts with (32)P-postlabeling also revealed genoty

297 method, we measured the levels of the three DNA adducts with the use of 10 mug of DNA isolated from

298 binding protein domain HMGB1a binds to CP-GG DNA adducts with up to 53-fold greater affinity than to

299 ective, we focus on the analysis of multiple DNA adducts within a sample with the emphasis on untarge

300 The lack of strategies to measure DNA adducts within genomic loci, however, limits our und