ライフサイエンスコーパス: DNA damage checkpoint

1 egulated by cyclin-dependent kinases and the DNA damage checkpoint.

2 on nucleosome dynamics is independent of the DNA damage checkpoint.

3 l part of the MBF core, is the target of the DNA damage checkpoint.

4 BP1) dimer is essential for establishing the DNA damage checkpoint.

5 pindle checkpoint but instead depends on the DNA damage checkpoint.

6 ing agents, even in mutants defective in the DNA damage checkpoint.

7 antagonizes the involvement of NOTCH1 in the DNA damage checkpoint.

8 op2 poison acriflavine (ACF), activating the DNA damage checkpoint.

9 required for replisome assembly and for the DNA damage checkpoint.

10 ted repair before the execution of an intact DNA damage checkpoint.

11 poptotic response of the conserved pachytene DNA damage checkpoint.

12 int, but they are compromised for the G(2)/M DNA damage checkpoint.

13 o replication and subsequently arrest at the DNA damage checkpoint.

14 cell cycle because of the activation of the DNA damage checkpoint.

15 ) in the G(2) phase, thereby attenuating the DNA damage checkpoint.

16 n determines the activation threshold of the DNA damage checkpoint.

17 ataxia telangiectasia and rad3 related-based DNA damage checkpoint.

18 complex, but they maintain an intact S phase DNA damage checkpoint.

19 nase that is the effector molecule in the G2 DNA damage checkpoint.

20 cts in gamma-H2AX induction, or an abrogated DNA damage checkpoint.

21 hat miR-106b overrides a doxorubicin-induced DNA damage checkpoint.

22 ath, as cells are unable to recover from the DNA damage checkpoint.

23 le and cooperate in ATR activation in the G1 DNA damage checkpoint.

24 r mutation that prevents induction of the G2 DNA damage checkpoint.

25 matid cohesion, and inactivated a third, the DNA damage checkpoint.

26 rmed recovery or when the cells adapt to the DNA damage checkpoint.

27 breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint.

28 ances and also functions in the ATR-mediated DNA damage checkpoint.

29 gulation of the metabolic checkpoint and the DNA damage checkpoint.

30 ouble-strand breaks (DSBs) that activate the DNA-damage checkpoint.

31 o DNA lesions and subsequent activation of a DNA-damage checkpoint.

32 DSBs persist are therefore eliminated by the DNA-damage checkpoint.

33 s a central anti-tumorigenic function of the DNA damage checkpoints.

34 from DNA double-strand breaks that activate DNA damage checkpoints.

35 ging agents and play a role in activation of DNA damage checkpoints.

36 ependent arrest is genetically distinct from DNA damage checkpoints.

37 cade to facilitate repair by HR and regulate DNA damage checkpoints.

38 imulate DNA damage and to activate host cell DNA damage checkpoints.

39 ATR/Chk1 to promote efficient activation of DNA damage checkpoints.

40 ich are also important for the activation of DNA damage checkpoints.

41 at requires interdependence with mediator of DNA damage checkpoint 1 (MDC1) and H2AFX.

42 sponse (DDR) proteins, including mediator of DNA damage checkpoint 1 (Mdc1) and p53 binding protein 1

43 n-induced gammaH2AX foci recruit mediator of DNA damage checkpoint 1 (MDC1) and p53 binding protein 1

44 d breaks and associates with the mediator of DNA damage checkpoint 1 (MDC1) and the ataxia telangiect

45 ce complex components (MCMs) and mediator of DNA damage checkpoint 1 (MDC1) expression.

46 53-binding protein 1 (53BP1) and Mediator of DNA damage checkpoint 1 (MDC1) to endogenous DSBs.

47 We show that mediator of DNA damage checkpoint 1 (MDC1), a binding partner of pho

48 ion together with recruitment of mediator of DNA damage checkpoint 1 (MDC1), and the Mre11-Rad50-Nbs1

49 phorylated H2AX (gammaH2AX), and mediator of DNA damage checkpoint 1 (MDC1), as well as components of

50 DNA damage factors such as NBS1, mediator of DNA damage checkpoint 1 (MDC1), RNF8, 53BP1, and BRCA1.

51 (H2AX, also known as H2AFX)- and mediator of DNA damage checkpoint 1 (MDC1)-dependent events.

52 lcNAcylation of histone H2AX and mediator of DNA damage checkpoint 1 (MDC1).

53 and blocks recruitment of MDC1 (mediator of DNA damage checkpoint 1) and 53BP1 (p53 binding protein

54 ited by gamma-H2AX and by MDC-1 (mediator of DNA damage checkpoint 1), which binds to gamma-H2AX in c

55 n of phosphorylated histone 2AX, mediator of DNA-damage checkpoint 1, and p53 binding protein 1, at D

56 e-strand breaks (DSBs) and activation of the DNA damage checkpoint [2-7].

57 nt transformation by enabling cells to evade DNA damage checkpoints activated by oncogenic stimuli.

58 HR is error-prone in this context because of DNA damage checkpoint activation and base pair lesions a

59 These data demonstrate that L1CAM augments DNA damage checkpoint activation and radioresistance of

60 for the recruitment of factors critical for DNA damage checkpoint activation and repair by homologou

61 rgeting L1CAM by RNA interference attenuated DNA damage checkpoint activation and repair, and sensiti

62 tions, we found that H3K14ac is critical for DNA damage checkpoint activation by directly regulating

63 nucleoprotein aggregates form in response to DNA damage checkpoint activation in egg chambers of fema

64 S phase arrest accompanied by gammaH2AX and DNA damage checkpoint activation in mouse embryonic fibr

65 , treated cells show slower DNA replication, DNA damage checkpoint activation, and an increased apopt

66 early passage primary MEFs is antagonized by DNA damage checkpoint activation, consistent with nuclea

67 Resection, the generation of ssDNA, affects DNA damage checkpoint activation, DNA repair pathway cho

68 knockdown is independent of p53 activation, DNA damage checkpoint activation, or changes in the AKT

69 ctly dependent on ATM-, but not ATR-mediated DNA damage checkpoint activation.

70 that result from Chk-2 (checkpoint kinase-2) DNA damage checkpoint activation.

71 eedback loop to limit ssDNA accumulation and DNA damage checkpoint activation.

72 ly regulates RAD53 transcription to suppress DNA damage checkpoint activation.

73 The metabolic conversion of ANI-7 induces DNA damage, checkpoint activation, S-phase cell cycle ar

74 ted acetylation of the ATM kinase, promoting DNA-damage-checkpoint activation and cell survival.

75 4 was required for rapid inactivation of the DNA damage checkpoint after DSB repair.

76 s is exacerbated by Pif1, which triggers the DNA damage checkpoint along a pathway involving Pif1's a

77 ns in further genes of the HR pathway or the DNA damage checkpoint also give rise to somatic mutation

78 nover of Mre11 at DNA ends, shutting off the DNA damage checkpoint and allowing cell cycle progressio

79 (GSCs) display a preferential activation of DNA damage checkpoint and are relatively resistant to ra

80 NUDT15 ablation potentiated induction of the DNA damage checkpoint and cancer cell death by 6-thiogua

81 upon ART-27 depletion include regulators of DNA damage checkpoint and cell cycle progression, sugges

82 RNR3 gene is dependent on activation of the DNA damage checkpoint and chromatin remodelling by SWI/S

83 signaling abrogates the activation of the G2 DNA damage checkpoint and confers specific sensitization

84 1 mutants were associated with activation of DNA damage checkpoint and depletion of dNTP concentratio

85 sDNA that is essential for activation of the DNA damage checkpoint and DNA repair by homologous recom

86 -2 are involved in the maintenance of a G2/M DNA damage checkpoint and DNA repair mediated by the non

87 f DNA damage by concurrently attenuating the DNA damage checkpoint and DNA repair, resulting in polyp

88 eactivation of these kinases from the G(2)/M DNA damage checkpoint and efficient checkpoint recovery.

89 lated by the recombination machinery and the DNA damage checkpoint and is likely an important aspect

90 This sustains the DNA damage checkpoint and is suppressed by Rad53 phospho

91 control the activity of cyclin A at the G(1) DNA damage checkpoint and may thereby prevent S-phase en

92 protein complex that impacts mammalian G2/M DNA damage checkpoint and NHEJ.

93 UmuD is implicated in a primitive DNA damage checkpoint and prevents DNA polymerase IV-dep

94 DNA damage checkpoint and recombinational repair are bot

95 o its loading mechanism and association with DNA damage checkpoint and repair enzymes.

96 omplex at DSBs occurs independently of known DNA damage checkpoint and repair proteins.

97 Mec1-Ddc2 (ATR-ATRIP) controls the DNA damage checkpoint and shows differential cell-cycle

98 cells that fail to launch a robust G2 phase DNA damage checkpoint and that this renders them sensiti

99 al mobility in G1 phase is controlled by the DNA damage checkpoint and the Rad51 recombinase.

100 sults from the age-related activation of the DNA damage checkpoint and the resulting degradation of h

101 In budding yeast, both the DNA damage checkpoint and the spindle assembly checkpoin

102 eveals a previously unknown function for the DNA damage checkpoint and the spindle position checkpoin

103 with well-defined functions in mitosis, the DNA damage checkpoint and the spindle position checkpoin

104 otein kinase Rad53 is a key regulator of the DNA damage checkpoint and uses its two FHA domains to in

105 protect telomeres against activation of the DNA damage checkpoints and recombinational repair.

106 as an essential factor for the initiation of DNA damage checkpoints and the maintenance of genomic st

107 mRNA turnover through the activation of the DNA-damage checkpoint and the Aft1/Aft2-controlled iron

108 ability to recruit telomerase, activates the DNA damage checkpoint, and loses heterochromatin at telo

109 and rid mutant viability is dependent on the DNA damage checkpoint, and surprisingly Mrc1, a protein

110 tor p21, which promotes cell-cycle arrest at DNA damage checkpoints, and Gadd45 and p53R2, with pivot

111 accumulated oxidative DNA damage, activated DNA damage checkpoints, and showed G1-phase arrest at at

112 specific DSBs, fail to properly activate the DNA-damage checkpoint, and show genetic interactions wit

113 Although DNA damage checkpoints are broadly activated in response

114 in DSB repair and the deoxyribonucleic acid (DNA) damage checkpoint are unclear.

115 cumulate on the lagging strand, resulting in DNA damage-checkpoint arrest and cell death.

116 Fun30 is required to allow the adaptation of DNA damage checkpoint-arrested cells with an unrepaired

117 G2/M DNA damage checkpoint, ATM signaling, mitochondrial dysf

118 of Obfc2b does not affect the initiation of DNA damage checkpoints, Atm activation, or the maintenan

119 This process is regulated by the DNA damage checkpoint, because RFWD3 is phosphorylated b

120 that the requirements for recovery from the DNA damage checkpoint become more stringent with increas

121 not only on Mec1 and other components of the DNA damage checkpoint but also on the presence of the ce

122 lethality that is dependent on the upstream DNA damage checkpoint but independent of the downstream

123 ive process resulting from activation of the DNA damage checkpoint by an ATR-regulated pathway, which

124 ether with UmuC, plays a role in a primitive DNA damage checkpoint by decreasing the rate of DNA synt

125 aries of spindle-class females, an activated DNA damage checkpoint causes inefficient Grk translation

126 cells compromised in DNA repair pathways or DNA damage checkpoints, cells reliant on homologous reco

127 The DNA damage checkpoint clamp (the 9-1-1 complex) has been

128 The yeast DNA damage checkpoint clamp Ddc1-Mec3-Rad17 (human Rad9-

129 loader, replication factor C (RFC), and the DNA damage checkpoint clamp loader, Rad24-RFC, using two

130 ork progression is reduced in the absence of DNA damage checkpoint components and nonhomologous end-j

131 to oncogenic transformation, and hyperactive DNA damage checkpoints, consistent with upregulated leve

132 ration down-regulation was associated with a DNA damage checkpoint consisting of p53, p21, and endoth

133 The DNA damage checkpoint, consisting of an evolutionarily c

134 These findings provide new insights into DNA damage checkpoint control and further underscore the

135 ary microcephaly, plays an important role in DNA damage checkpoint control and mitotic entry.

136 ctivity of HPV-16 E7 involves attenuation of DNA damage checkpoint control by accelerating the proteo

137 Here we show that the CHK2 (CHEK2)-dependent DNA damage checkpoint culls not only recombination-defec

138 The DNA damage checkpoint (DDC) is often robustly activated

139 sponse to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the ce

140 ved signal transduction cascade known as the DNA damage checkpoint (DDC).

141 st in cell-cycle progression enforced by the DNA-damage checkpoint (DDC) signalling pathway positivel

142 Despite the underlying DNA damage checkpoint defects, increased DNA damage sign

143 avior of cells after they have experienced a DNA damage checkpoint delay is poorly characterized.

144 ion, we define a role for MRN in the S-phase DNA damage checkpoint-dependent slowing of replication t

145 in various cellular processes including the DNA damage checkpoint, DNA repair, and transcription.

146 nd Mrc1 experience chronic activation of the DNA damage checkpoint during chromosome replication and

147 bly of signaling complexes that activate the DNA damage checkpoint effector kinase Chk1.

148 Here we show that the DNA-damage checkpoint eliminates oocytes via the pro-apo

149 acterized genes, including mRNA splicing and DNA damage checkpoint factors.

150 3 postreplication repair complex, downstream DNA-damage checkpoint factors (Rad53, Chk1, and Dun1), o

151 r have been known to be downregulated by the DNA damage checkpoint for many years.

152 uire homologous recombination repair and the DNA damage checkpoint for viability.

153 Aberrant regulation of DNA damage checkpoint function leads to genome instabili

154 We found that Dss1p and Rae1p have a DNA damage checkpoint function, and upon treatment with

155 Rad17 in either activation or termination of DNA damage checkpoint function.

156 on fork metabolism, are required for S-phase DNA damage checkpoint function.

157 In addition to a structural role, Mrc1 has a DNA damage checkpoint function.

158 howed increased expression of cell cycle and DNA damage checkpoint genes (false discovery rate <0.25;

159 caused by disruption of either MEC1 or RAD53 DNA damage checkpoint genes, as well as the lethality se

160 itates this phenotype because it can repress DNA damage checkpoint genes.

161 egulatory step controlling activation of the DNA damage checkpoint in Bacillus subtilis.

162 n stress, DNA damage, and abrogates the G(2) DNA damage checkpoint in both normal and malignant cells

163 s (CAFs), Asf1 and CAF-1, in turning off the DNA damage checkpoint in budding yeast.

164 Finally, we suggest escaping this DNA damage checkpoint in maternal ageing may be one of t

165 Previous work on the DNA damage checkpoint in Saccharomyces cerevisiae has sh

166 n Rad4(TopBP1) facilitates activation of the DNA damage checkpoint in Schizosaccharomyces pombe by ph

167 ication DNA repair enzymes and activates the DNA damage checkpoint in the G2 cell cycle phase.

168 V treatment, and the noted abrogation of the DNA damage checkpoint in the MTA1-depleted cells may be,

169 ohesin is also required for the integrity of DNA damage checkpoints in somatic cells, where cohesin l

170 p1cc), and leads to frequent mutagenesis and DNA damage checkpoint induction.

171 In one example, a pathway-based screen for DNA damage checkpoint inhibitors identified a compound,

172 insic genotoxic stress and susceptibility to DNA damage checkpoint inhibitors.

173 The G2 DNA damage checkpoint inhibits Cdc2 and mitotic entry th

174 urbed conditions and the DNA replication and DNA damage checkpoints into a single transcriptional com

175 However, it remains unclear how the DNA damage checkpoint is activated by oxidative stress a

176 This lack of an efficient DNA damage checkpoint is because oocytes fail to effecti

177 minent when a DSB is slowly repaired and the DNA damage checkpoint is fully activated.

178 tinct mechanism of how an ATR-Chk1-dependent DNA damage checkpoint is mediated by APE2 in the oxidati

179 udding yeast (Saccharomyces cerevisiae), the DNA damage checkpoint is regulated by a signaling cascad

180 E7 maintains proliferation despite activated DNA damage checkpoints is incompletely understood.

181 Thus, SAC, much like the DNA damage checkpoint, is essential for genome stability

182 point kinase 1 (Chk1), a component of the G2 DNA damage checkpoint, is important in the resistance of

183 caused by mutations in the gene encoding the DNA damage checkpoint kinase ATM, is characterized by mu

184 blocks the serine 345 phosphorylation of the DNA damage checkpoint kinase Chk1 by Rad3 (ATR) at broke

185 sensitive to single-agent inhibition of the DNA damage checkpoint kinase Chk1, leading us to examine

186 The DNA damage checkpoint kinase Mec1(ATR) is critical for m

187 etion of the Trp53 tumor suppressor or Chek2 DNA damage checkpoint kinase rescued Smc5 cKO neurodevel

188 e tumour cells to clinical inhibitors of the DNA damage checkpoint kinase, ATR, both in vitro and in

189 nto nuclear foci and activation of the Rad53 DNA damage checkpoint kinase, indicating that the toxici

190 tumor suppressor genes Egr1 and JunB and the DNA damage checkpoint kinase, polo-like kinase 2 (Plk2)

191 nuclei from syncytial blastoderm embryos via DNA damage checkpoint kinase-mediated retention of speci

192 ere, we show that, in the absence of induced DNA damage, checkpoint kinase-1 (CHK1), an enzyme essent

193 ssolvase complex (BLM-TOP3A-RMI1/2, or BTR), DNA damage checkpoint kinases (ATR and Chk1), HR protein

194 nds the existing knowledge of the targets of DNA damage checkpoint kinases and provides insights into

195 esponse to DNA damage is orchestrated by the DNA damage checkpoint kinases ATAXIA TELANGIECTASIA MUTA

196 DNA damage checkpoint kinases ATR and WEE1 are among key

197 ion of the Eya2 phosphatase activity and the DNA damage checkpoint kinases Chk1 and Chk2 in wild-type

198 In normal cells, p53 is activated by DNA damage checkpoint kinases to simultaneously control

199 These phosphorylations were dependent on the DNA damage checkpoint kinases, Mec1/Tel1 and Rad53.

200 s (CDK), Dbf4-dependent kinase (DDK) and the DNA damage checkpoint kinases.

201 the core component of NHEJ, partnering with DNA-damage checkpoint kinases ataxia telangiectasia muta

202 Besides canonical DNA damage checkpoint-mediated phosphorylation, DNA dama

203 strains with deletions of both ISC1 and the DNA damage checkpoint mediator gene RAD9 display reduced

204 letion of the conserved helicase PIF1 and/or DNA damage checkpoint-mediator RAD9.

205 In the S-phase DNA damage checkpoint, MRN acts both in activation of ch

206 Novel targeted therapies against the DNA damage checkpoint or stem-cell maintenance pathways

207 Recently, strategies aimed at targeting DNA damage checkpoints or DNA repair processes have demo

208 in GGR are not achieved by either activating DNA damage checkpoints or regulating the expression of t

209 We propose that the DNA damage checkpoint pathway coordinates resection and

210 We find the DNA damage checkpoint pathway facilitates HR, in part, b

211 nuclear extensions, whereas inactivating the DNA damage checkpoint pathway in a DNA repair mutant red

212 Here we identify roles for the DNA damage checkpoint pathway in facilitating homologous

213 The DNA damage checkpoint pathway is activated in response t

214 her MTA1 also participates in the UV-induced DNA damage checkpoint pathway remains unknown.

215 To determine whether reduced activity in the DNA damage checkpoint pathway would cooperate with MMR d

216 plex functions as a mediator in the ATR-Chk1 DNA damage checkpoint pathway.

217 participates in the UV-induced ATR-mediated DNA damage checkpoint pathway.

218 Delta cells and relieves the reliance on the DNA damage checkpoint pathway.

219 The Chk2-mediated deoxyribonucleic acid (DNA) damage checkpoint pathway is important for mitochon

220 AD1], Mitotic Arrest-Deficient 2 [MAD2]) and DNA-damage-checkpoint pathway (e.g., Mitosis Entry Check

221 ated gene sets with concurrent activation of DNA damage checkpoint pathways as compared with Mtg16(-/

222 DNA damage checkpoint pathways operate to prevent cell-c

223 ication fork protection, and DNA replication/DNA damage checkpoint pathways.

224 eak (DSB) repair, meiotic recombination, and DNA damage checkpoint pathways.

225 Although the DNA damage checkpoint PI3-kinases ATM and ATR localize t

226 The DNA damage checkpoint plays a crucial role in maintainin

227 IIalpha mutant activated the ATM/R-dependent DNA damage checkpoint, probably due to reduced catalytic

228 , where it plays a key role in advancing the DNA damage checkpoint process.

229 es a docking site to recruit the mediator of DNA damage checkpoint protein 1 (MDC1) and DNA repair pr

230 des interact with phosphorylated mediator of DNA damage checkpoint protein 1 (phospho-MDC1) or E3 ubi

231 cycle checkpoint proteins MDC1 (mediator of DNA damage checkpoint protein 1) and BRCA1 (breast cance

232 it the DDR factors because MDC1 (mediator of DNA damage checkpoint protein 1), which normally binds t

233 dies have found that TRF2 interacts with the DNA damage checkpoint protein Chk2.

234 ablished that Cdc2 kinase phosphorylates the DNA damage checkpoint protein Crb2(53BP1) in mitosis, th

235 The DNA damage checkpoint protein Hus1 associates with Rad9

236 53BP1, first identified as a DNA damage checkpoint protein, and BRCA1, a well-known b

237 onstrate that by fusing AtCRY2 to the TopBP1 DNA damage checkpoint protein, light-induced AtCRY2 PBs

238 Mediator of DNA Damage Checkpoint protein, MDC1, and H2AX are chroma

239 , XPA, XPC, TFIIH, XPG, and XPF-ERCC1), core DNA damage checkpoint proteins (ATR-ATRIP, TopBP1, RPA),

240 Here, we find that within minutes of DNA damage checkpoint proteins are assembled at the kine

241 which include mechanisms of RFP regulation, DNA damage checkpoint proteins, as well as kinases that

242 n promotes DSB processing and recruitment of DNA damage checkpoint proteins, thus implicating cohesin

243 for binding by homologous recombination and DNA damage checkpoint proteins.

244 In response to DNA damage, checkpoint proteins halt cell cycle progress

245 The requirement for specific DNA-damage checkpoint proteins suggests roles in recruit

246 ed PLK1 at threonine 210, a prerequisite for DNA damage checkpoint recovery, remained detectable foll

247 and its degradation plays a critical role in DNA damage checkpoint recovery.

248 Here we show that the DNA damage checkpoint regulating S-phase entry is contro

249 t progress has advanced our understanding of DNA damage checkpoint regulations, little is known as to

250 how chromatin remodeling complexes regulate DNA damage checkpoints remain unclear.

251 Activation of DNA damage checkpoints requires the rapid accumulation o

252 DNA damage cause a metabolic checkpoint and DNA damage checkpoint, respectively.

253 n, aberrant replication, and activation of a DNA damage checkpoint response (DDR), rendering therapeu

254 biquitin-ligase CRL4 controls cell cycle and DNA damage checkpoint response and ensures genomic integ

255 s the signal that activates the ATR-mediated DNA damage checkpoint response and that the signal is en

256 -mimetic agent to analyze the basic steps of DNA damage checkpoint response in a biochemically define

257 iRNAs genetically interact with genes in the DNA damage checkpoint response pathway and in the insuli

258 ivates signaling through the Chk1 arm of the DNA damage checkpoint response via recruitment and stimu

259 However, no deficiencies in DNA damage checkpoint response were detected in Cdc14b m

260 cleotide damage repair, mismatch repair, and DNA damage checkpoint response, but its function in DNA

261 ecause many activated oncoproteins trigger a DNA damage checkpoint response, which serves as a barrie

262 um essential set of factors for ATR-mediated DNA damage checkpoint response.

263 the 9-1-1 checkpoint complex to enhance the DNA damage checkpoint response.

264 te origins become active despite an elevated DNA damage-checkpoint response.

265 l32, and Rad5) and in the early steps of the DNA-damage checkpoint response (Rad17, Mec3, Ddc1, Mec1,

266 unction for IKK and NF-kappaB modulating the DNA-damage checkpoint response, allowing the cell to int

267 d protein that coordinates activation of the DNA-damage-checkpoint response by coupling binding of th

268 Chk1 is a key regulator of DNA damage checkpoint responses and genome stability in

269 ed damage through preferential activation of DNA damage checkpoint responses and increased capacity f

270 st that the HPV-16 E7 oncoprotein alleviates DNA damage checkpoint responses and promotes mitotic ent

271 Here, we show that L1CAM (CD171) regulates DNA damage checkpoint responses and radiosensitivity of

272 of cyclin D1b was not sufficient to abrogate DNA damage checkpoint responses, it did efficiently over

273 that L1CAM signals through NBS1 to regulate DNA damage checkpoint responses.

274 NBS1 (MRN), thereby repressing ATM-dependent DNA damage checkpoint responses.

275 us to dissect MRN's ATM-independent S-phase DNA damage checkpoint roles from its role in ATM activat

276 tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein c

277 critical feature of the human ATR-initiated DNA damage checkpoint signaling has not been demonstrate

278 dephosphorylation of Rad53 when the upstream DNA damage checkpoint signaling is turned off.

279 ents form bulky lesions on DNA that activate DNA damage checkpoint signaling pathways in human cells.

280 In fission yeast, DNA damage checkpoint signaling requires Rad3, the homol

281 uires that promitotic activity must override DNA damage checkpoint signaling to drive proliferation.

282 asia mutated and Rad3-related (Atr)-mediated DNA damage checkpoint signaling, including activation of

283 n-induced foci (TIFs), indicating defects in DNA damage checkpoint signaling.

284 ble-strand breaks (DSBs), and by attenuating DNA damage checkpoint signaling.

285 nates the processing and repair of DSBs with DNA damage checkpoint signalling, preserving genome inte

286 In response to DNA damage, checkpoint signalling protects genome integr

287 protein kinase is an important transducer of DNA damage checkpoint signals, and its mutation contribu

288 Here we show that the conserved DNA damage checkpoint sliding clamp (the 9-1-1 complex)

289 The S-phase DNA damage checkpoint slows the rate of DNA synthesis in

290 ex to damaged DNA, leading to both premature DNA damage checkpoint termination and inhibition of DNA

291 protein kinase that is a key mediator of the DNA damage checkpoint that responds to DNA double-strand

292 ranscriptase activity and the Chk2-dependent DNA damage checkpoint to prevent FOA.

293 lar processes that include activation of the DNA damage checkpoint, transient cell cycle arrest, DNA

294 al that loss of miRNA biogenesis activates a DNA damage checkpoint, up-regulates p19(Arf)-p53 signali

295 Rad3 and Rad3-mediated phospho-signaling in DNA damage checkpoint were moderately reduced in the tel

296 breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3

297 ion was associated with activation of a G2/M DNA damage checkpoint, which prevented activation of the

298 In Saccharomyces cerevisiae, the DNA damage checkpoint, which responds to lesions such as

299 uble-strand breaks (DSBs), and activation of DNA damage checkpoints, which in primary human cells lea

300 DNA repair and DNA damage checkpoints work in concert to help maintain