ライフサイエンスコーパス: DNA demethylation

1 insights into how TET and TDG mediate active DNA demethylation.

2 DG-abasic product dissociation during active DNA demethylation.

3 TET2 catalyzes DNA demethylation.

4 ndard of care, mesna or nicotinamide-induced DNA demethylation.

5 ylcytosine (5hmC), thereby initiating active DNA demethylation.

6 d play a role in gene expression mediated by DNA demethylation.

7 een DNA methylation and ROS1-mediated active DNA demethylation.

8 itical roles in DNA base excision repair and DNA demethylation.

9 ession is partly maintained by TET2-mediated DNA demethylation.

10 ts stability and positively regulates active DNA demethylation.

11 s 5hmC, but also initiates active or passive DNA demethylation.

12 r oxidized methylcytosines, intermediates in DNA demethylation.

13 ndelian disorder caused by the disruption of DNA demethylation.

14 rate HBx induces EpCAM expression via active DNA demethylation.

15 es and meta-plasticity of neurons via active DNA demethylation.

16 which is enriched in brain, and its ultimate DNA demethylation.

17 ate by modulating chromatin architecture and DNA demethylation.

18 o 5-hydroxymethylcytosine (5 hmC) to mediate DNA demethylation.

19 ss in understanding the mechanism underlying DNA demethylation.

20 able, post-mitotic neurons exhibit extensive DNA demethylation.

21 epigenetic marks and likely intermediates in DNA demethylation.

22 estigations into the biological functions of DNA demethylation.

23 n the mechanism and function of TET-mediated DNA demethylation.

24 xylcytosine (5caC), thereby mediating active DNA demethylation.

25 genic pathways and inhibition of histone and DNA demethylation.

26 of mutations in IDM1, a regulator of active DNA demethylation.

27 by thymine DNA glycosylase (TDG), leading to DNA demethylation.

28 y of 5mC dioxygenases and an intermediate of DNA demethylation.

29 cision repair, transcription regulation, and DNA demethylation.

30 reprogramming, which includes comprehensive DNA demethylation.

31 enetic marks and potential intermediates for DNA demethylation.

32 evelopment and in PGCs at the time of global DNA demethylation.

33 d 5caC, connecting 5mC oxidation with active DNA demethylation.

34 ility led to genomic and methylated reporter DNA demethylation.

35 as been hypothesized to edit RNA and mediate DNA demethylation.

36 ethyltransferases and components involved in DNA demethylation.

37 lycosylase TDG, implicating 5mC oxidation in DNA demethylation.

38 oxyglutarate as an inhibitor of TET-mediated DNA demethylation.

39 y embryo, are resistant to vitamin-C-induced DNA demethylation.

40 ne has greatly advanced our understanding of DNA demethylation.

41 -ray cross-complementing group protein 1) in DNA demethylation.

42 by reexpression of miRNAs upon pharmacologic DNA demethylation.

43 idized 5mC derivatives and initiating active DNA demethylation.

44 igase SIZ1 as a critical regulator of active DNA demethylation.

45 enomes that occurs as intermediate of active DNA demethylation.

46 ient mESCs show no involvement of epigenetic DNA demethylation.

47 ctivated in VCs, mostly by DEMETER-catalyzed DNA demethylation.

48 xidized methylcytosines are intermediates in DNA demethylation.

49 performing the last of the multiple steps in DNA demethylation.

50 ER factors are due to DNA damage or impaired DNA demethylation.

51 e Tet family of enzymes that are involved in DNA demethylation.

52 roxymethylcytosine (5hmC), which can lead to DNA demethylation.

53 e up-regulating Tet1 and Tet2, which promote DNA demethylation.

54 ocation (TET) family members regulate active DNA demethylation.

55 the DNA glycosylase ROS1, which facilitates DNA demethylation.

56 The mammalian TET enzymes catalyze DNA demethylation.

57 The mammalian germline undergoes extensive DNA demethylation(3-7) that occurs in large part by pass

58 the central role of BER in mediating active DNA demethylation, a multistep process that erases the e

59 DNA demethylation, a process involving DNA repair, is cr

60 UMOylation of key BER proteins during active DNA demethylation-a role they demonstrate to be importan

61 ative and high-resolution analysis of active DNA demethylation activity remains challenging.

62 ation by coordinating efficient TDG-mediated DNA demethylation along with active transcription during

63 t4 promoter, Oplr16 recruited TET2 to induce DNA demethylation and activate Oct4 in fibroblasts, lead

64 ely, our findings suggest that Tet2 promotes DNA demethylation and activation of cytokine gene expres

65 ing osteoblast differentiation as it impairs DNA demethylation and alters the recruitment of histone

66 views of 5hmC as a transient intermediate in DNA demethylation and as a modified DNA base with an ins

67 The link between inhibition of DNA demethylation and changes in expression is strong in

68 ensive epigenome resetting, including global DNA demethylation and chromatin reorganization.

69 ugh a functional relationship between active DNA demethylation and chromatin structure is often impli

70 FOXA1-dependent enhancers and mediates local DNA demethylation and concomitant histone 3 lysine 4 met

71 oxidase TET proteins play important roles in DNA demethylation and development.

72 ance of genomic integrity but also in active DNA demethylation and epigenetic gene regulation.

73 ydroxymethylcytosine, which promotes passive DNA demethylation and functions as an intermediate in an

74 creased DNA methylation 2) as a regulator of DNA demethylation and gene silencing.

75 exes underscores the coordination of histone/DNA demethylation and genome repair during gene activati

76 Our results indicate that DNA demethylation and histone acetylation are coordinate

77 n, which in turn can be further amplified by DNA demethylation and histone deacetylase inhibitors pro

78 ombinatorial cancer immunotherapy harnessing DNA demethylation and IFN-gamma response.

79 esults suggest that IDM2 functions in active DNA demethylation and in antisilencing by regulating IDM

80 A correlation between promoter DNA demethylation and injury-dependent gene induction wa

81 TDG functions in active DNA demethylation and is essential for embryonic develop

82 aKG to succinate ratio that promotes histone/DNA demethylation and maintains pluripotency.

83 ype of IDH mutant glioma was associated with DNA demethylation and poor outcome; a group of IDH-wild-

84 Impaired DNA demethylation and reduced chromatin accessibility in

85 ions of Tet3 and DNA replication in paternal DNA demethylation and reveals an unexpected contribution

86 advantage of its recently discovered role in DNA demethylation and selective recognition and repair o

87 ithout ascorbate (vitamin C), which promotes DNA demethylation and subsequently changes the sensitivi

88 at maternal vitamin C is required for proper DNA demethylation and the development of female fetal ge

89 with the known functions of TET proteins in DNA demethylation and the known distribution of 5hmC at

90 e methyltransferase Dnmt1 induces widespread DNA demethylation and transcriptional activation of ERVs

91 ver, direct connections between TET-mediated DNA demethylation and transcriptional output are difficu

92 r progression, in part, through the specific DNA demethylation and upregulation of epidermal growth f

93 anistically, peripheral nerve injury induces DNA demethylation and upregulation of multiple regenerat

94 pressed H1 suppresses TEs in VCs by reducing DNA demethylation and via a methylation-independent mech

95 Mechanistically, XCR requires both DNA demethylation and Xist silencing, ensuring that only

96 We focus on DNA methylation, DNA demethylation, and common histone tail modifications

97 ne (5hmC), providing an active mechanism for DNA demethylation, and it may also provide its own regul

98 oduced similar systemic decitabine exposure, DNA demethylation, and safety vs decitabine 20 mg/m2 IV

99 contribute to adaptive and innate immunity, DNA demethylation, and the modification of cellular mRNA

100 Global DNA demethylation appears to be a shared attribute of re

101 Thus, tissue-specific DNA demethylation appears to be necessary for proper som

102 ine (5mC)) and their removal by TET-mediated DNA demethylation are critical for setting up pluripoten

103 Tet proteins and DNA demethylation are key regulators of embryonic stem c

104 , but the mechanisms of regulation of active DNA demethylation are not well understood.

105 n vitro PGC (iPGC) formation and genome-wide DNA demethylation are unaffected by the absence of Tet1

106 Modulation of histone and DNA demethylation, as well as HIF-1alpha stability, medi

107 e oxidized methylcytosines, intermediates in DNA demethylation, as well as new epigenetic marks.

108 rease in the level of 5hmC with accompanying DNA demethylation at a subset of CGIs.

109 Early DNA demethylation at certain enhancers prospectively mar

110 reveals a role for Tet proteins in not only DNA demethylation at enhancers but also regulating the 2

111 function as a cancer therapy via histone and DNA demethylation at genes involved in differentiation a

112 ogonia also displayed developmentally linked DNA demethylation at meiotic genes and also at certain m

113 This effect correlated with rapid DNA demethylation at reprogramming enhancers and increas

114 nner and coordinates histone acetylation and DNA demethylation at SEs.

115 enge [i.e., forced swimming (FS)] results in DNA demethylation at specific CpG (5'-cytosine-phosphate

116 We found that localized DNA demethylation at the H19 imprinting control region (

117 ecting temporally specific changes in active DNA demethylation at the promoter of plasticity-related

118 th the recruitment of Gadd45gamma and active DNA demethylation at the same site, which is necessary f

119 xp3 in regulatory T cells (Tregs) depends on DNA demethylation at the Treg-specific demethylated regi

120 Genetic and pharmacological DNA demethylation, but also cancer-associated DNA hypome

121 dilution both contribute to global paternal DNA demethylation, but demethylation of the maternal gen

122 RNF4 does not promote DNA demethylation, but mediates the ubiquitination of Me

123 lly controlled by DNA methylation and active DNA demethylation, but the mechanisms of regulation of a

124 that TET2, a cellular enzyme that initiates DNA demethylation by converting 5-methylcytosine (5mC) i

125 on of TET2, a cellular enzyme that initiates DNA demethylation by converting 5-methylcytosine (5mC) i

126 sion-suppressor miRNAs by inhibiting genomic DNA demethylation by direct targeting of TET1, thereby l

127 allelic expression is correlated with active DNA demethylation by DNA glycosylases and repressive tar

128 effect is likely the result of both passive DNA demethylation by DNMTi and active conversion of 5-me

129 2 (ten-eleven translocation), which promotes DNA demethylation by oxidizing 5-methylcytosine (5mC) to

130 e Tet 5-methylcytosine dioxygenases catalyze DNA demethylation by producing 5-hydroxymethylcytosine a

131 17 and BLIMP1, drives comprehensive germline DNA demethylation by repressing DNA methylation pathways

132 essive cell divisions, accompanied by active DNA demethylation by TET enzymes(3,8-10).

133 2 were previously shown to facilitate active DNA demethylation by the 5-methylcytosine DNA glycosylas

134 pon miR-494 overexpression, whereas enforced DNA demethylation can abolish the repression.

135 MT targeting protein, UHRF1, can augment the DNA demethylation capacities of existing DNA methylation

136 tes at key transitioning steps of the active DNA demethylation cascade and reveals a regulatory role

137 In the germline, promoter DNA demethylation coincides with expression of Dppa2 and

138 Our results show that active DNA demethylation combats the activity of RNA-directed D

139 an exogenous source of alphaKG restored the DNA demethylation cycle by promoting TDG function, TET1

140 Restoring the epimetabolic control of DNA demethylation cycle promises beneficial effects on c

141 pathway represents a replication-independent DNA demethylation cycle.

142 expression through a mechanism regulated by DNA demethylation-dependent nuclear hormone receptor rec

143 In Arabidopsis, active DNA demethylation depends on the function of the ROS1 su

144 SNORD116 cluster may protect the PWS-IC from DNA demethylation during early development.

145 l processes, including the genome-wide/local DNA demethylation during early embryogenesis, cell diffe

146 a methylcytosine dioxygenase that initiates DNA demethylation during early zygote formation, embryog

147 small non-coding RNA mediated regulation on DNA demethylation dynamics and the differential expressi

148 Lost expression of a key DNA demethylation enzyme TET2 is associated with human c

149 ome of cells that have emerged from a global DNA demethylation event.

150 two oxidized 5mC bases indicative of active DNA demethylation events.

151 DNA demethylation facilitated CCCTC-binding factor (CTCF

152 long interspersed nuclear element 1 (LINE-1) DNA demethylation for oral cedazuridine/decitabine vs IV

153 n important regulatory role of Tet-dependent DNA demethylation for the maintenance of DNA methylation

154 y, suggesting a requirement for Tet-mediated DNA demethylation for the proper regulation of gene expr

155 Uncoupling DNA demethylation from antisense transcription by Tet3 o

156 D and streptozotocin mice eliciting, in HFD, DNA demethylation, glucose uptake, and insulin response.

157 Although global DNA demethylation has been observed after treatment, it

158 DNA demethylation has been primarily studied in the cont

159 Therefore, bypassing stage-specific DNA demethylation has significant consequences for proge

160 tic mark, yet no human Mendelian disorder of DNA demethylation has yet been delineated.

161 ered epigenetic mark produced through active DNA demethylation, has not been previously investigated

162 ocessing oxidized 5mC derivatives to achieve DNA demethylation have emerged.

163 e gametogenesis facilitates DEMETER-directed DNA demethylation, heterochromatin relaxation, and TE ac

164 We sought to investigate the role of DNA demethylation in activating inflammasome genes durin

165 precursor protein cleaving enzyme 1 (bace-1) DNA demethylation in AD-vulnerable brain regions.

166 Weng et al. (2017) reveal a role for active DNA demethylation in allowing axon regeneration to occur

167 nd functions at several stages during active DNA demethylation in Arabidopsis.

168 cancer cells can be partially reactivated by DNA demethylation in cells disrupted for the DNA methylt

169 TDG could potentially be useful for studying DNA demethylation in cells.

170 ate (alphaKG) in the epimetabolic control of DNA demethylation in CMSCs.

171 length TET1 (TET1-FL) induces massive global DNA demethylation in differentiated cells.

172 SCs recapitulated the process of genome-wide DNA demethylation in embryonic PGCs, including significa

173 Evidence that AID promotes DNA demethylation in epigenetic reprogramming phenomena,

174 none exposure leads to active and functional DNA demethylation in HEK293 cells in a mechanism involvi

175 Global DNA demethylation in humans is a fundamental process tha

176 ew, we discuss the mechanism and function of DNA demethylation in mammalian genomes, focusing particu

177 Active DNA demethylation in mammals involves oxidation of 5-met

178 Active DNA demethylation in mammals involves TET-mediated itera

179 of Dppa3 facilitated the emergence of global DNA demethylation in mammals.

180 and thus provide a possible means for active DNA demethylation in mammals.

181 The cellular function of active DNA demethylation in neurons, however, remains largely u

182 at DPPA3 alone is capable of inducing global DNA demethylation in non-mammalian species (Xenopus and

183 s a resource to facilitate future studies of DNA demethylation in pathogenesis and the development of

184 nctional consequence of abrogating two-stage DNA demethylation in PGCs was precocious germline differ

185 e regulatory elements that escape systematic DNA demethylation in PGCs, providing a potential mechani

186 Active DNA demethylation in plants is mediated by a family of D

187 est a requirement for Tet- and 5hmC-mediated DNA demethylation in proper regulation of gene expressio

188 recently been shown to have a role in active DNA demethylation in reprogramming toward pluripotency a

189 ent accelerator of global and locus-specific DNA demethylation in somatic and pluripotent stem cells.

190 TET1 (TET1) has been shown to promote active DNA demethylation in the nervous system.

191 Maternal obesity induces DNA demethylation in the promoter of zinc finger protein

192 Development-specific genes often undergo DNA demethylation in their promoter and other regions, w

193 echanisms and critical functional players of DNA demethylation in this process remain largely unexplo

194 lcytosine in these regions implicated active DNA demethylation in this process.

195 vels of TET enzyme, which is responsible for DNA demethylation in UVB-exposed skin.

196 thermore, the biological functions of active DNA demethylation in various biological contexts have al

197 Genome-wide DNA "demethylation" in the zygote involves global TET3-m

198 c DNA methylation, and downstream targets of DNA demethylation, in incubation of cocaine craving.

199 nd that inhibition of DNA replication blocks DNA demethylation independently from Tet3 function and t

200 c heterochromatin regions are protected from DNA demethylation independently of EHMT2 and SETDB1.

201 5-carboxylcytosine, the last intermediate in DNA demethylation, indicating successful on-target activ

202 In ESCs with DNA demethylation induced by acute deletion of Dnmt1, we

203 We further establish that DNA demethylation induced by XPC expression in somatic c

204 lants exhibit a reduced capacity to complete DNA demethylation initiated by ROS1.

205 Active DNA demethylation involves stepwise oxidation of mC to 5

206 Active DNA demethylation involves TET-mediated stepwise oxidati

207 Genome-wide DNA demethylation is a unique feature of mammalian devel

208 RESSOR OF SILENCING 1 (ROS1)-mediated active DNA demethylation is critical for shaping the genomic DN

209 To assess if PD-1 promoter DNA demethylation is impacted by prolonged stimulation d

210 erved losses in methylation, suggesting that DNA demethylation is mediated by TF binding to cis-actin

211 Hydroxymethylation and subsequent DNA demethylation is more complex and involves additiona

212 and mouse cells, and 5-azacytidine triggered DNA demethylation is more pronounced at CpG sites with f

213 This study provides evidence that DNA demethylation is part of a plant-induced immune resp

214 implicated in hydroxymethylation and active DNA demethylation, is a key regulator of EBV latency typ

215 ical model, which accurately predicts global DNA demethylation kinetics.

216 from Tet3 function and that Tet3 facilitates DNA demethylation largely by coupling with DNA replicati

217 Emerging evidence suggests that active DNA demethylation machinery plays important epigenetic r

218 g (WGBS) analysis revealed that Tet-mediated DNA demethylation mainly occurs at distally located enha

219 inding sequence, supporting that this active DNA demethylation mechanism functions during oncogenic t

220 We also show that DDB2 regulates active DNA demethylation mediated by REPRESSOR OF SILENCING 1 (

221 anied by decreased nucleosome enrichment and DNA demethylation mediated by SWI/SNF- and Tet1/Tet2-con

222 lved antisilencing mechanisms such as active DNA demethylation mediated by the REPRESSOR OF SILENCING

223 onstrate a new role for Elongator in somatic DNA demethylation/methylation and suggest a function for

224 Our results reveal that DNA demethylation modulates enhancer activity, and its d

225 recovered as second-site suppressors of the DNA demethylation mutant ros1-1.

226 inery that is responsible for the HG-induced DNA demethylation observed.

227 In PGCs, global and locus-specific DNA demethylation occur in sequential stages, with an in

228 tosine-dioxygenase-2 (TET2), a key enzyme in DNA demethylation, occur in cardiovascular disease and a

229 Potent dose-related DNA demethylation occurred on the daily x 5 regimen, rea

230 DG, but the mechanism by which TDG-dependent DNA demethylation occurs in a rapid and site-specific ma

231 Global DNA demethylation occurs in the early embryo and the ger

232 erall hypomethylated state and site specific DNA demethylation of enhancer elements within the proxim

233 Here we report widespread DNA demethylation of enhancers during the phylotypic per

234 a and interleukin-2 to activate Tet-mediated DNA demethylation of Foxp3 to promote immune tolerance.

235 onse to maternal genome dosage imbalance and DNA demethylation of male gametes.

236 This is followed by DNA demethylation of many gene promoters and upregulatio

237 T1B, increasing histone H3K4 methylation and DNA demethylation of numerous phosphatase-encoding genes

238 Specific DNA demethylation of regulatory sequences can result in

239 Consistently, forcing global DNA demethylation of SCC-TAFs with 5-AZA rescued TGFbeta

240 MSP and bisulfite sequencing indicated DNA demethylation of slug and CD87 genes.

241 ring development is accompanied by extensive DNA demethylation of specific sites that vary between ce

242 tends through the sense promoter, leading to DNA demethylation of the CTCF binding sites proximal to

243 Downregulation is caused by DNA demethylation of the gene bodies and restoration of

244 of human colorectal tumors exhibit aberrant DNA demethylation of the GM-CSF promoter and overexpress

245 DNA demethylation of the trophoblast like cell lines BeW

246 A strong dependence of 5-azacytidine-induced DNA demethylation on hENT1 activity was also confirmed b

247 hes the embryo, exhibits extensive localized DNA demethylation on maternally inherited chromosomes.

248 Furthermore, DNA demethylation on such loci leads to reactivation of

249 However, an active DNA demethylation pathway is initiated during late seed

250 as an initiating step of mitosis-independent DNA demethylation pathways and has not yet been observed

251 ess of TET-5hmC pathways and reveal critical DNA demethylation patterns.

252 rocess where regulatory components mediating DNA demethylation play a leading role.

253 ROS1-mediated DNA demethylation plays a critical role in the regulatio

254 Collectively, our results show that DNA demethylation plays a limited role to the establishm

255 Here, we show that TET2-mediated DNA demethylation plays a primary role in the de novo es

256 Tet-mediated DNA demethylation plays an important role in shaping the

257 cellular tumor suppressor involved in active DNA demethylation, plays a central role in regulating th

258 ses Tet1 and Tet2 in the initial genome-wide DNA demethylation process has not been examined directly

259 Our biochemical understanding of the DNA demethylation process has prompted new investigation

260 s and indicate that TET/TDG-dependent active DNA demethylation process occurs extensively in the mamm

261 nd functions as an intermediate in an active DNA demethylation process.

262 methylation, hydroxymethylation, and active DNA demethylation provide a framework for the identifica

263 dogenous gene loci and validate programmable DNA demethylation reagents with potential utility for re

264 Whether and how DNA demethylation regulates the expression of SAGs and t

265 ocation (TET) family of dioxygenase-mediated DNA demethylation requires new methods to quantitatively

266 methylated ros1 mutant, which is affected in DNA demethylation, revealed that their opposite resistan

267 neurological disorders are also resistant to DNA demethylation, revealing potential for transgenerati

268 stage of human NK cell development in which DNA demethylation takes place to allow for active transc

269 In DNA demethylation, TDG excises 5-formylcytosine (fC) and

270 Essential for DNA demethylation, TDG excises 5-formylcytosine and 5-ca

271 ed patients with CAPS undergo more efficient DNA demethylation than those of healthy subjects.

272 embryogenesis, including initial genome-wide DNA demethylation that establishes the germline epigenet

273 TET enzymes catalyse DNA demethylation through 5-methylcytosine oxidation.

274 These experiments demonstrate that DNA demethylation through 5fC/5caC has roles distinct fr

275 pecies are reported to have a role in active DNA demethylation through 5mC oxidation and DNA repair,

276 translocation (TET) proteins are involved in DNA demethylation through iteratively oxidizing 5-methyl

277 teins are the key enzymes involved in active DNA demethylation through stepwise oxidation of 5mC.

278 r order chromatin structure regulates active DNA demethylation through TDG and provides novel insight

279 oxidize 5-methylcytosine to initiate active DNA demethylation through the base-excision repair (BER)

280 silence somatic gene expression and dynamic DNA demethylation to activate pluripotency gene transcri

281 ution methylome analysis reveals progressive DNA demethylation to basal levels in week 5-7 in vivo hP

282 nts triggered by TET catalysis, ranging from DNA demethylation to chromatin and transcription regulat

283 oncoding sequence 2 (CNS2), is activated via DNA demethylation to establish epigenetic memory of Foxp

284 enetic barrier that can be removed by active DNA demethylation to permit axon regeneration in the adu

285 genetic reprogramming by regionally opposing DNA demethylation to preserve vital parental information

286 t may be exploited to facilitate therapeutic DNA demethylation to reverse kidney fibrosis.

287 In a low-immunogenic tumor model, DNA demethylation upregulates cryptic transcript express

288 ew methods for the genomic mapping of active DNA demethylation using limited numbers of cells or sing

289 To understand mammalian active DNA demethylation, various methods have been developed t

290 nases have also been proposed to function in DNA demethylation via deamination of either 5-methylcyto

291 Active DNA demethylation via ten-eleven translocation (TET) fam

292 The mechanism is NaCl-induced DNA demethylation via the recruitment of the hydroxytran

293 SFN enhances active DNA demethylation viaTet1andTet2and promotes preosteobla

294 genase 2 (TET2) and nuclear factor kappaB to DNA demethylation was tested by using chromatin immunopr

295 and ten-eleven translocation (Tet)-dependent DNA demethylation, which contribute to the regulation of

296 dependent repair of DNA lesions arising from DNA demethylation, which prevents zygotes carrying unrep

297 e expression profiling after pharmacological DNA demethylation with functional screening to identify

298 is resource to monitor the outcome of global DNA demethylation with reversion of primed PSCs to the n

299 ut7 in murine CD4(+) T cells correlates with DNA demethylation within a minimal promoter in skin/infl

300 In conclusion, we show that DNA demethylation within the fut7 gene controls selectin