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1 tion of Fz, showing that it is an RNA-guided DNA endonuclease.
2 oluble fraction does indeed act as a nicking DNA endonuclease.
3 i-functional maturase protein that is also a DNA endonuclease.
4  future re-engineering of minimal RNA-guided DNA endonucleases.
5 ndromic repeat (CRISPR)/Cas-based RNA-guided DNA endonucleases.
6  break at defined locations by site-specific DNA endonucleases.
7 neering of universal programmable RNA-guided DNA endonucleases.
8 tified TnpB proteins as miniature RNA-guided DNA endonucleases(2,3).
9 ed that TnpB and IscB function as RNA-guided DNA endonucleases(5,6), but the broader biological role
10  phosphate for bottom-strand cleavage at the DNA endonuclease active site and then reposition the 3'
11 ode reverse transcriptase, RNA maturase, and DNA endonuclease activities for site-specific DNA insert
12 -encoded reverse transcriptase, maturase and DNA endonuclease activities for site-specific insertion
13 that has both RNA maturase and site-specific DNA endonuclease activities in vitro.
14 gger both the transcriptional activation and DNA endonuclease activities of a Cas9-VPR protein, drivi
15 oded reverse transcriptase and site-specific DNA endonuclease activities required for this process.
16               In eukaryotic cells, a 5' flap DNA endonuclease activity and a ds DNA 5'-exonuclease ac
17                         This single-stranded DNA endonuclease activity can act at all single-stranded
18                                          The DNA endonuclease activity of the enzyme is specific for
19          As for the yeast mtDNA introns, the DNA endonuclease activity of the Lactococcal intron is a
20 We also demonstrate that the single-stranded DNA endonuclease activity of this T. thermophilus domain
21 eA inhibits this mechanism of HGT in cis via DNA endonuclease activity that is localized to the perip
22 vatives displays DNA-binding specificity and DNA endonuclease activity that is similar to that of the
23 oded reverse transcriptase uses a C-terminal DNA endonuclease activity to cleave the opposite strand
24 The Rad1-Rad10 complex has a single-stranded DNA endonuclease activity.
25 ndent endonuclease activity and a non-guided DNA endonuclease activity.
26 However, PALF also possesses single-stranded DNA endonuclease activity.
27 presumed not to be mutagenic, as dCas9 lacks DNA endonuclease activity.
28 he addition of exogenous Zn(2+) inhibits the DNA endonuclease activity.
29          Interestingly the protein is also a DNA endonuclease, an activity required for intron mobili
30 ossesses manganese-dependent single-stranded DNA endonuclease and 3' to 5' exonuclease activities.
31 purified from yeast, it is a single-stranded DNA endonuclease and a DNA-dependent ATPase, suggesting
32  of the Affymetrix p53 chip and the Surveyor DNA endonuclease and denaturing high-performance liquid
33 s with purified proteins and DNAs along with DNA endonuclease and in vivo integration assays, we show
34 I-Ssp6803I represents a novel intron-encoded DNA endonuclease and is the first example of a chromosom
35 eading-frame encoding reverse transcriptase, DNA endonuclease and nucleic acid-binding domains.
36 ngle polypeptide with reverse transcriptase, DNA endonuclease and nucleic acid-binding domains.
37 we show that the Streptococcus pyogenes Cas9 DNA endonuclease and single guide RNAs (sgRNAs) produced
38 in and excised intron RNA have site-specific DNA endonuclease and target DNA-primed reverse transcrip
39                      CRISPR-associated (Cas) DNA-endonucleases are remarkably effective tools for gen
40 , and is a member of the LAGLIDADG family of DNA endonucleases, but appears to have lost DNA cleavage
41 n from Aspergillus nidulans encodes a homing DNA endonuclease called I-AniI which also functions as a
42 , requires sequence-specific single-stranded DNA endonucleases called relaxases or nickases.
43                          Cas9, an RNA-guided DNA endonuclease, can be targeted to specific genomic se
44 eases (LHEs) are a family of highly specific DNA endonucleases capable of recognizing target sequence
45                               The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA target
46                               The RNA-guided DNA endonuclease Cas9 cleaves double-stranded DNA target
47 nd breaks (DSBs) generated by the RNA-guided DNA endonuclease Cas9 determine how gene function is alt
48                               The RNA-guided DNA endonuclease Cas9 has emerged as a powerful tool for
49 ted (Cas) systems employ the dual RNA-guided DNA endonuclease Cas9 to defend against invading phages
50                             As an RNA-guided DNA endonuclease, Cas9 can be easily programmed to targe
51 ne systems in bacteria use a dual RNA-guided DNA endonuclease, Cas9, to cleave foreign DNA at specifi
52                The multifunctional XPF-ERCC1 DNA endonuclease complex acts in several DNA repair path
53 ng divalent cations in other systems such as DNA-endonuclease complexes and ribozymes.
54                     Deployment of RNA-guided DNA endonuclease CRISPR-Cas technology has led to radica
55  mechanism of a cOA-activated CRISPR defence DNA endonuclease, CRISPR ancillary nuclease 1 (Can1).
56 1, redox effector-1), a key redox sensor and DNA endonuclease critical for oxidative DNA damage repai
57 thally engage apoptotic caspases to activate DNA endonuclease DNA fragmentation factor B (also known
58 ease EXO1 and heterodimeric complexes of the DNA endonuclease DNA2, with either the BLM or WRN helica
59      Structures of Cap4 reveal a promiscuous DNA endonuclease domain activated through ligand-induced
60  that encode proteins lacking the C-terminal DNA endonuclease domain and for group II intron retrotra
61 ype and mutant LtrA proteins showed that the DNA endonuclease domain contains a single tightly bound
62   A UV-cross-linking assay showed that these DNA endonuclease domain mutations do not block DNA prime
63                     Notably, deletion of the DNA endonuclease domain or mutations in its conserved se
64 ified features of the DNA-binding region and DNA endonuclease domain that are conserved in LtrA and r
65 at contributes to DNA binding, followed by a DNA endonuclease domain that contains conserved sequence
66 the intron-encoded protein uses a C-terminal DNA endonuclease domain to cleave the opposite strand an
67 the intron-encoded protein uses a C-terminal DNA endonuclease domain to cleave the opposite strand an
68 licing, while the C-terminal DNA-binding and DNA endonuclease domains are not required.
69 ins have reverse transcriptase, maturase and DNA endonuclease domains characteristic of canonical gro
70      We describe SegF, a novel site-specific DNA endonuclease encoded by gene 69, which is similar to
71  LAGLIDADG and HNH families of site-specific DNA endonucleases encoded by viruses, bacteriophages as
72     Homing endonucleases are highly specific DNA endonucleases, encoded within mobile introns or inte
73 thermophilus Argonaute (TtAgo), a DNA-guided DNA endonuclease, finds, binds, and cleaves its targets.
74                          Cas9, an RNA-guided DNA endonuclease found in clustered regularly interspace
75 gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system.
76                   PI-SceI, a double-stranded DNA endonuclease from Saccharomyces cerevisiae, is gener
77                         Cas9, the RNA-guided DNA endonuclease from the CRISPR-Cas (clustered regularl
78 e GAL1 promoter joined to PvuII, a bacterial DNA endonuclease gene, are toxic to yeast cells even und
79                   The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of adva
80 tion-modification (R-M) systems consist of a DNA endonuclease (HsdR, HsdM and HsdS subunits) and meth
81                       The introns encode the DNA endonucleases I-HmuI and I-HmuII, respectively, whic
82 at this intronic ORF encodes a double-strand DNA endonuclease, I-Ssp6803I.
83                           Intron 2 encodes a DNA endonuclease, I-TwoI, with similarity to homing endo
84 reveals the general utility of site-specific DNA endonucleases in producing targeted homologous recom
85 rved sequence motifs characteristic of H-N-H DNA endonucleases, interspersed with two pairs of conser
86                 CRISPR-Cas9 is an RNA-guided DNA endonuclease involved in bacterial adaptive immunity
87                              MUS81-EME1 is a DNA endonuclease involved in replication-coupled repair
88  ERCC1-XPF heterodimer, a structure-specific DNA endonuclease, is best known for its function in the
89           The enzymes are as follows: MPE, a DNA endonuclease; Lhr-Core, a 3'-5' DNA helicase; LIG, a
90 ochemical specificities, as main actors, the DNA endonuclease MUS81 and the protease WSS1A, and the p
91 trons, the Bastille intron encodes a nicking DNA endonuclease of the H-N-H family, I-BasI, with a cle
92 h repair (MMR) complexes MutSB and MutLa and DNA endonuclease Rad1, followed by end-resection by Exo1
93  group J protein (FACJ, BRIP1)-deficient, or DNA endonuclease RBBP8 (CtIP)-compromised cells, whereas
94  we characterized the C-terminal DNA-binding/DNA endonuclease region of the LtrA protein encoded by t
95 g applications of CRISPR-Cas9, an RNA-guided DNA endonuclease, require precision control of Cas9 acti
96                                     Mus81, a DNA endonuclease required for recovery from collapsed fo
97        The DNase was able to digest circular DNA (endonuclease), required both Ca(2+) and Mg(2+) ions
98                    Overexpression of the RNA:DNA endonuclease RNAse H1 rescues the DNA synthesis defe
99 independent ICL repair mechanism, in which a DNA endonuclease(s) unhooks an ICL from the leading stra
100   For the filament-forming sequence-specific DNA endonuclease SgrAI, the process of filamentation bot
101 re converted to double-strand breaks using a DNA endonuclease (Surveyor) and oligonucleotide tails ar
102             Cas9 is a prokaryotic RNA-guided DNA endonuclease that binds substrates tightly in vitro
103                         Human XPF-ERCC1 is a DNA endonuclease that incises a damaged DNA strand on th
104  putida MPE protein is a manganese-dependent DNA endonuclease that incises either linear single stran
105  The td intron of bacteriophage T4 encodes a DNA endonuclease that initiates intron homing to cognate
106 nd Slx4 are subunits of a structure-specific DNA endonuclease that is found in Saccharomyces cerevisi
107                          GajA functions as a DNA endonuclease that is inactive in the presence of ATP
108 associated with the excised intron to form a DNA endonuclease that mediates intron mobility by target
109 ity) and then with the excised intron form a DNA endonuclease that mediates intron mobility by target
110 ith the excised intron, form a site-specific DNA endonuclease that promotes intron mobility by revers
111 se activity, telomerase is associated with a DNA endonuclease that removes nucleotides from a primer
112 ) the putative HEG encodes a double-stranded DNA endonuclease that specifically cleaves intron-free h
113 ldin complex, ASTE1, as a structure-specific DNA endonuclease that specifically cleaves single-strand
114                        Cas9 is an RNA-guided DNA endonuclease that targets foreign DNA for destructio
115                 Gabija protein A (GajA) is a DNA endonuclease that tetramerizes to form the core of t
116 SPR-associated protein Cas9 is an RNA-guided DNA endonuclease that uses RNA-DNA complementarity to id
117   Homing endonucleases are sequence-tolerant DNA endonucleases that act as mobile genetic elements.
118 on splicing (maturases) or are site-specific DNA endonucleases that function in intron mobility (a pr
119 member of a new family of structure-specific DNA endonucleases that interact with the replication cla
120                    They encode site-specific DNA endonucleases that perpetuate the element within a s
121 t are required for splicing of the intron or DNA endonucleases that promote intron mobility.
122                    NAE:I is transformed from DNA endonuclease to DNA topoisomerase and recombinase by
123  which employs Surveyor, a mismatch-specific DNA endonuclease, to remove errors from synthetic genes.
124 verse N-terminal effector domains, including DNA endonucleases, to abrogate infection.
125 g properties of the well-studied, DNA-guided DNA endonuclease, TtAgo, an Argonaute protein from the E
126 present enAsCas12f, an engineered RNA-guided DNA endonuclease up to 11.3-fold more potent than its pa
127  we characterize Fanzors as RNA-programmable DNA endonucleases, using biochemical and cellular eviden
128        Schizosaccharomyces pombe ultraviolet DNA endonuclease (UVDE or Uve1p) has been shown to cleav
129 from Streptococcus pyogenes is an RNA-guided DNA endonuclease, which has become the most popular geno
130 uI and I-BasI are two highly similar nicking DNA endonucleases, which are each encoded by a group I i
131 from Streptococcus pyogenes is an RNA-guided DNA endonuclease with widespread utility for genome modi
132          Cpf1 is a novel class of CRISPR-Cas DNA endonucleases, with a wide range of activity across
133 l clade of manganese-dependent single-strand DNA endonuclease within the binuclear metallophosphoeste
134 urmise that MPE exemplifies a novel clade of DNA endonuclease within the binuclear metallophosphoeste
135 hila homolog of the human structure-specific DNA endonuclease XPF.

 
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