ライフサイエンスコーパス: DNA methylation

1 histone post-translational modifications and DNA methylation.

2 endogenous base modifications in the form of DNA methylation.

3 fering RNAs (siRNAs) that guide RNA-directed DNA methylation.

4 two major regulatory sequences controlled by DNA methylation.

5 hestrated by epigenetic mechanisms including DNA methylation.

6 ation, and prevents DRD1-mediated changes in DNA methylation.

7 on of genetic variation to transcription and DNA methylation.

8 om chromatin, thereby inhibiting maintenance DNA methylation.

9 netic information to their daughters through DNA methylation.

10 phaffii, a yeast species lacking endogenous DNA methylation.

11 histone H3, hypoacetylation of histones, and DNA methylation.

12 vely, in the absence of mammalian readers of DNA methylation.

13 specificity to an ATPase step essential for DNA methylation.

14 hese effects can be blocked by inhibitors of DNA methylation.

15 e was the most effective means of inhibiting DNA methylation.

16 abundance of T regulatory cells regulated by DNA methylation.

17 weeks of gestation were largely unrelated to DNA methylation.

18 al cortex exhibit hemispheric differences in DNA methylation.

19 , and this is magnified when cells also lack DNA methylation.

20 ed understanding of epigenetic regulation by DNA methylation.

21 a nuclear effector of MILI to silence TEs by DNA methylation.

22 s the purpose of this intriguing turnover of DNA methylation?

23 eveloped to infer cell-type proportions from DNA methylation, a comparative evaluation of the perform

24 DNA methylation, a prominent epigenetic mark, also chang

25 Such functionality plausibly explains why DNA methylation, a well-known mutagen, has been maintain

26 uent evolutionary trajectories for SCNAs and DNA methylation aberrations.

27 e reveal unexpected variation in patterns of DNA methylation across arthropods and examples of gene f

28 , we find that DNA topology can shape non-CG DNA methylation across the genome to dictate MeCP2-media

29 plants, suggesting that poor maintenance of DNA methylation activates PVCV.

30 atin structure but only localized changes in DNA methylation, adding another example of the dynamics

31 psychopathology in association with advanced DNA methylation age across several brain regions, to ext

32 that previous associations between predicted DNA methylation age and neurodegenerative phenotypes mig

33 epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in 331 individuals with AUD and 201

34 and how its histone core is affected through DNA methylation, an important regulator of transcription

35 which considerably limited the scope of the DNA methylation analysis in those studies.

36 Genome-wide-DNA methylation analysis revealed dynamic changes in nod

37 t epi-drugs that target histone deacetylase, DNA methylation and bromodomain proteins.

38 asets shows an unanticipated overlap between DNA methylation and chromatin accessibility at enhancers

39 olecules (IgCAMs) as direct substrates, with DNA methylation and chromatin accessibility profiling un

40 Motif analysis of differential DNA methylation and chromatin accessibility regions asso

41 We produce epigenome maps, including DNA methylation and chromatin accessibility, as well as

42 Widespread changes to DNA methylation and chromatin are well documented in can

43 mbination of epigenetic mechanisms including DNA methylation and chromatin modifications.

44 elling (for example, PBRM1, BAP1 and SETD2), DNA methylation and DNA damage repair, all of which have

45 udies have demonstrated associations between DNA methylation and environmental factors with evidence

46 ramework that learns the association between DNA methylation and expression using both gene- and cell

47 hat capture the complex relationship between DNA methylation and gene expression and predict gene act

48 Genome-wide DNA methylation and gene expression are commonly altered

49 at there was an inverse relationship between DNA methylation and gene expression for HOXB1, HOXA3 and

50 We also observed associations between DNA methylation and gene expression for the PIK3CD sites

51 multi-omics data enables measurement of both DNA methylation and gene expression for the same single

52 1 month, and 3 months of life, and measured DNA methylation and gene expression profiles in upper ai

53 ng on how the histone code drives changes in DNA methylation and highlight the complex interplay betw

54 ethylation-deficient cells demonstrates that DNA methylation and histone deacetylation act largely in

55 We reveal that POL2A inhibits DNA methylation and histone H3 lysine 9 methylation.

56 terations in metabolic enzymes that regulate DNA methylation and histone post-translational modificat

57 ) for targeted base-resolution sequencing of DNA methylation and hydroxymethylation in regions up to

58 Nevertheless, DNA methylation and recombination rate are anticorrelate

59 , which cooperates with MAT2alpha to promote DNA methylation and represses antioxidant and anti-infla

60 in the mouse genome are heavily modified by DNA methylation and repressive histone modifications.

61 enhancer activity which may be modulated by DNA methylation and SOX9 overexpression.

62 y reprogrammed through the global erasure of DNA methylation and the exchange of histones with protam

63 of DNA and through enzymatic activities for DNA methylation and/or chromatin modifications generates

64 usal genetic variants between lung function, DNA methylation, and gene expression by using a multiple

65 asures of mRNA expression, miRNA expression, DNA methylation, and histone acetylation from ASD and co

66 mechanisms, including small noncoding RNAs, DNA methylation, and histone modifications, contribute t

67 of somatic copy number alterations (SCNAs), DNA methylation, and point mutations in lung cancer driv

68 D dataset consisting of histone acetylation, DNA methylation, and RNA transcription data from human c

69 e the finding that heterochromatin and genic DNA methylation are highly variable among 725 A. thalian

70 Taken all together, KRAS-mediated DNA methylation are stochastic and independent of canoni

71 The Illumina 450 K DNA-methylation array was used on whole blood samples of

72 Using 850K DNA methylation arrays we compared the methylomes of you

73 ndidates involved in periodicity, and reveal DNA methylation as an important regulator of circadian p

74 This study is the first to identify variable DNA methylation associated with all-cause mortality in s

75 sdam cohort, revealed 105 genes with altered DNA methylation at 605 cytosine-phosphate-guanine (CpG)

76 egulation of SNX19 expression and found that DNA methylation at CpG sites near the primary transcript

77 Here, we comprehensively examine DNA methylation at enhancers, genome-wide, in neurons of

78 obese mice, occupancy of SHP and DNMT3A and DNA methylation at lipogenic genes are low, with elevate

79 atients with DNMT3 mutations exhibit reduced DNA methylation at regions that are hypomethylated in Dn

80 te the effect of smoking on FEV(1), although DNA methylation at some sites might influence lung funct

81 The non-CpG DNA methylation at telomere fits a binomial model and ma

82 DNA methylation at the 5-position of cytosine (5mC) play

83 DNA methylation at the INSR and IGF2 gene promoter regio

84 We discuss the discovery of the DNA methylation-based biomarkers for biological tissue a

85 veal biologically significant differences in DNA methylation between homologous alleles associated wi

86 ethylated regions (DMRs), most of which gain DNA methylation between the early and late stages of dec

87 urther demonstrated that global differential DNA methylation bidirectionally regulated these same gen

88 We identify DNA methylation biomarkers associated with PrCa, and our

89 While epigenetic marks such as DNA methylation can affect gene function and change in r

90 Thus, direct regulation of DNA methylation can prevent/reverse diabetic retinopathy

91 ructural consequences of DNMT3A mutations on DNA methylation catalysis and binding interactions and s

92 Furthermore, genome-wide loss of DNA methylation caused a loss of O-GlcNAc from multiple

93 DNA methylation changes associated with cancer-related g

94 etic mechanisms, in particular gene-specific DNA methylation changes at distinct subtelomeric regions

95 fic pattern and abundance of copy number and DNA methylation changes at these TFs and targets, compar

96 ulation in chondrocytes we characterised the DNA methylation changes during chondrogenesis of mesench

97 Increased gonadal DNA methylation changes following nicotine reexposure in

98 Highly reproducible smoking-associated DNA methylation changes in whole blood have been reporte

99 Future research should explore whether DNA methylation changes mediate associations between pre

100 ce of breakage-fusion-bridge cycles and high DNA methylation changes related to the proliferative cel

101 tered chromatin interactions, partially with DNA methylation changes, and rarely with sequence mutati

102 s with massive epigenetic alterations on the DNA methylation, chromatin accessibility and histone mod

103 into pancreatic islets in vitro by profiling DNA methylation, chromatin accessibility, and histone mo

104 icrodeletion on genome-wide gene expression, DNA methylation, chromatin accessibility, and sensitivit

105 , we utilized integrated genomic analysis of DNA methylation, chromatin accessibility, transcription

106 tation information, with new developments in DNA methylation classification.

107 Existing DNA methylation clocks have been shown to be highly accu

108 ows on a recently published brain tumor 450k DNA methylation cohort of 2,801 samples with 91 diagnost

109 which are characterized by global losses of DNA methylation coupled with localized ectopic gains of

110 COCOA is the first such tool for DNA methylation data and can also analyze any epigenetic

111 to simultaneously cluster sparse single-cell DNA methylation data and impute missing values.

112 ylation score that can be used on adolescent DNA methylation data and thereby generate a score for in

113 such stochastic events using pedigree-based DNA methylation data as input.

114 forms virtual microdissection of bulk tissue DNA methylation data at single cell-type resolution for

115 protocol for reference-free deconvolution of DNA methylation data comprising: (i) data preprocessing,

116 alysed whole-genome, whole-transcriptome and DNA methylation data for 208 pairs of tumour tissue samp

117 itary and civilian, contribute blood-derived DNA methylation data from 1,896 PTSD cases and trauma-ex

118 Multiple ChIP-seq data and DNA methylation data generated from brain were used for

119 Human DNA methylation data have been used to develop biomarker

120 DNA methylation data-based precision cancer diagnostics

121 CP estimates for precision diagnostics using DNA methylation data.

122 s disease (AD) and Down syndrome (DS), using DNA methylation datasets from public sources (Gene Expre

123 Functional consequences of DNA methylation-deficiency under control and stress cond

124 ounced additive effect of HDAC inhibition in DNA methylation-deficient cells demonstrates that DNA me

125 anscription factor occupancy in wild-type or DNA methylation-deficient mouse embryonic stem cells fol

126 While both methods robustly detected DNA methylation-dependent binding of MeCP2 to mCG and mC

127 DNA methylation did not clearly mediate the effect of sm

128 DNA methylation differences in Alzheimer's disease (AD)

129 In adults, deviations from the DNA methylation (DNAm) age prediction are correlated wit

130 DNA methylation (DNAm) contributes to asthma pathogenesi

131 DNA methylation (DNAm) has been shown to be associated w

132 DNA methylation (DNAm) is an epigenetic regulator of gen

133 of Cd and smoking exposures with human blood DNA methylation (DNAm) profiles.

134 at uses summary-level data from cohort-based DNA methylation (DNAm) quantitative trait locus (mQTL) s

135 Mutations in genes involved in DNA methylation (DNAme; for example, TET2 and DNMT3A) ar

136 is essential for establishment of mammalian DNA methylation during development.

137 s similar Dnmt3b isoforms facilitate de novo DNA methylation during embryonic development and in soma

138 n, adding another example of the dynamics of DNA methylation during plant development.

139 Changes in DNA methylation during TN-DCIS progression in this canin

140 ze recent understanding of the regulation of DNA methylation dynamics in mammalian germ lines and ear

141 Here, we show that removal of DNA methylation enables CTCF binding and recruitment of

142 ubles the number of published syndromes with DNA methylation episignatures and, most significantly, o

143 ring the end of their reproductive lifespan, DNA methylation fidelity is lost at a number of CpG isla

144 Whether smoking-associated DNA methylation has a causal effect on lung function has

145 mber of studies have reported that bacterial DNA methylation has important functions beyond the roles

146 of the measures were sensitive in detecting DNA methylation heterogeneity in these scenarios, while

147 files of Ewing sarcoma samples, we show that DNA methylation heterogeneity provides information compl

148 ifications of these viral genomes, including DNA methylation, histone modification, chromatin remodel

149 studies of joint tissues that have examined DNA methylation, histone modifications and regulatory RN

150 profiles of central epigenetic regulators of DNA methylation, histone modifications and RNA methylati

151 hat a complex epigenetic machinery involving DNA methylation, histone modifications, and microRNAs me

152 These include DNA methylation, histone modifications, and regulation o

153 Epigenetic mechanisms, including DNA methylation, histone post-translational modification

154 NA methyltransferase, is crucial to maintain DNA methylation homeostasis to ensure genome integrity.

155 s of maternal SMCHD1 does not alter germline DNA methylation imprints pre-implantation or later in ge

156 DNA methylation in a fungal pathogen has persisted for m

157 ycyclic aromatic hydrocarbons interacts with DNA methylation in association with Attention Deficit Hy

158 hine Decarboxylase 1 (ODC1), are affected by DNA methylation in early stage UC.

159 cial isolation can alter gene expression and DNA methylation in higher cognitive centers of the brain

160 Here, we analyze de novo DNA methylation in mouse embryonic fibroblasts (2i-MEFs)

161 rmer smokers.Methods: We assayed genome-wide DNA methylation in non-Hispanic white smokers with and w

162 We quantified genome-wide levels of DNA methylation in peripheral blood mononuclear cells (P

163 Increased DNA methylation in Ppargc1a promoter had a fetal origin;

164 ustment for multiple comparisons, with lower DNA methylation in PTSD cases relative to controls.

165 nally, exposed fish exhibited differences in DNA methylation in selected genes, across all three gene

166 ow-based scores that quantify variability in DNA methylation in sequencing reads have been proposed.

167 The results suggest an important role of DNA methylation in the normal homeostasis of cardiomyocy

168 ng, we identify examples where site-specific DNA methylation in turn mediates gene expression, includ

169 n a feed-forward fashion to promote aberrant DNA methylation in UC.

170 cer patients potentially mediated by 365,307 DNA methylations in the TCGA lung cancer cohort.

171 Cytosine (DNA) methylation in plants regulates the expression of g

172 stone modifications, and in parent-of-origin DNA methylation including the H19/MIR675 locus (paternal

173 ian neurons are enriched for unique forms of DNA methylation, including exceptionally high levels of

174 ed with the level of iCGI transcription in a DNA-methylation independent manner.

175 DNA methylation is a major silencing mechanism of transp

176 Perturbation of host DNA methylation is a mechanism induced by chronic infect

177 DNA methylation is a ubiquitous chromatin feature, prese

178 DNA methylation is an epigenetic mark with important reg

179 DNA methylation is an epigenetic modification of the hum

180 DNA methylation is an epigenetic modification that speci

181 ompared with other epigenetic modifications, DNA methylation is an ideal marker for clinical purposes

182 ntified and widespread epigenetic marker 6mA DNA methylation is associated with gene expression, plan

183 DNA methylation is fine-mapped at enhancers and promoter

184 Our results suggest that placental DNA methylation is fundamentally linked to the regulatio

185 ons of PD patients, hemispheric asymmetry in DNA methylation is greater than in controls and involves

186 For example, DNA methylation is known to regulate transcription facto

187 ings support a paradigm in which maintenance DNA methylation is required in distinct regions of the T

188 The epigenome, including DNA methylation, is stably propagated during mitotic div

189 man pluripotency results in acquisition of a DNA methylation landscape mirroring the cancer DNA methy

190 nine TN-DCIS progression and investigate the DNA methylation landscape of normal breast tissue, atypi

191 he chromatin maintenance network, the global DNA methylation landscape remained highly stable, with l

192 combined effects of these regulators on the DNA methylation landscape using a panel of knockout huma

193 ty provides information complementary to the DNA methylation level.

194 Deletion of the cluster results in decreased DNA methylation levels and altered histone modifications

195 levels, frontal cortical Th total percentage DNA methylation levels and serum corticosterone levels,

196 Here, we characterize DNA methylation levels in six different tissues from 3 s

197 hat HD is accompanied by profound changes of DNA methylation levels in three mammalian species.

198 The comparison of mouse data with DNA methylation levels of incident T2D cases from the pr

199 genes from repression via repelling PRC2 and DNA methylation machineries.

200 riable and context-specific activity for the DNA methylation machinery.

201 heritable epimutations originate mainly from DNA methylation maintenance errors during mitotic rather

202 63 reconstructed and experimentally measured DNA methylation maps of ancient and present-day humans,

203 Mediation analysis with high-dimensional DNA methylation markers is important in identifying epig

204 mortality.Objectives: We sought to identify DNA methylation marks in blood that are predictive of mo

205 DNA methylation marks may provide important causal and p

206 DNA methylation may be involved in development of type 1

207 othesis raised by our data is that increased DNA methylation may contribute to the efficiency of alte

208 with evidence also supporting the idea that DNA methylation may modify the risk of environmental fac

209 We report a blood-DNA-methylation measure that is sensitive to variation i

210 The commonly used DNA methylation measurement approaches, e.g., Illumina I

211 all, our findings suggest that variations in DNA methylation mediate the differential expression of a

212 Our study identifies DNA-methylation-mediated transcriptional repression as a

213 , we used two-step MR to investigate whether DNA methylation mediates the effect of smoking on FEV(1)

214 Here, we describe the results of the largest DNA methylation meta-analysis of PTSD to date.

215 Genome-wide transcription (n = 192) and DNA methylation (n = 66) profiles were generated using A

216 Furthermore, DNA methylation of CG and CHG sites in the promoter regi

217 ed alterations in behavior and total percent DNA methylation of hippocampal Bdnf.

218 pture bisulfite-sequencing, we find that CHH DNA methylation of most 24-PHAS loci is increased in mei

219 nal preconception FAs are related to newborn DNA methylation of specific CpG sites, highlighting the

220 cell-types in a tumor, can be inferred from DNA methylation of surgical specimens.

221 neurotrophic factor (BDNF) and total percent DNA methylation of Th and Bdnf genes in the frontal cort

222 DNA methylation of various genomic regions has been foun

223 und evidence of a possible causal effect for DNA methylation on FEV(1) at 18 CpGs (p < 1.2 x 10(-4)).

224 We investigated the ability of a DNA methylation panel (the S5 classifier) to discriminat

225 e cell cycle progression and perturbs global DNA methylation patterning in the genome.

226 re powerful tools for estimating variance in DNA methylation patterns and have the potential for dete

227 use retinal ganglion cells restores youthful DNA methylation patterns and transcriptomes, promotes ax

228 NMT3A and DNMT3B specificity suggesting that DNA methylation patterns are guided by the sequence pref

229 Hemispheric differences in DNA methylation patterns are prevalent in neurons and ma

230 Our analyses indicate that DNA methylation patterns associated with the susceptible

231 on changes, alternative splicing events, and DNA methylation patterns during nodule formation, develo

232 analysis of aged and cancerous cell-specific DNA methylation patterns for diagnostic and prognostic p

233 mediated, at least in part, through altered DNA methylation patterns in upper airway mucosal cells.

234 We found that DNA methylation patterns were highly conserved between t

235 turally segregate into 2 groups according to DNA methylation patterns, related to normal MBC and PC p

236 ation of histone H3 lysine 36 (H3K36me3) and DNA methylation play a role in generating transcriptome

237 DNA methylation plays a critical role in regulating gene

238 Deoxyribonucleic acid (DNA) methylation plays a crucial role in human health.

239 biological age differences, we also examined DNA methylation predictors of smoking, alcohol, body mas

240 In vertebrates, DNA methylation predominantly occurs at CG dinucleotides

241 Although aberrant gene expression and DNA methylation profiles are considered hallmarks of col

242 We associated blood DNA methylation profiles from 581 MDD patients at baseli

243 The DNA methylation profiles in relevant cell types are alte

244 Using recently published DNA methylation profiles of Ewing sarcoma samples, we sh

245 We identified evolutionary divergence in the DNA methylation profiles of populations derived from the

246 trieve these components without the need for DNA methylation profiles of purified cell types.

247 In the present study, we show that DNA-methylation profiles from plasma reveal highly speci

248 They confirm the utility of DNA methylation profiling as a tool for causal gene prio

249 All DMB/MBEN assessed by DNA methylation profiling belonged to the SHH-INF subgro

250 Genome-wide DNA methylation profiling revealed differential promoter

251 DNA methylation profiling revealed that MEKi-induced T(S

252 d next-generation sequencing and array-based DNA methylation profiling to determine the clinically ac

253 epigenetic dysregulation, including altered DNA methylation, promotes PAH.

254 related to beneficial neonatal outcomes with DNA methylation proposed as a mechanism; however, few st

255 ciated with adverse offspring outcomes, with DNA methylation proposed as a mediating mechanism.

256 it studies, such as chromatin accessibility, DNA methylation, protein expression and metabolite level

257 chnologies has deepened our understanding of DNA methylation regulation in germ lines and early stage

258 observed significant enrichment of candidate DNA methylation related to C-reactive protein and body m

259 in this transition, the complete picture of DNA methylation remains elusive.

260 In female mice, we observed DNA methylation reprogramming in bone marrow-derived (BM

261 Indeed, near-complete DNA methylation reprogramming, as occurs during mammalia

262 Although activity-related loss of DNA methylation requires the Gadd45 (Growth arrest and D

263 Local levels of DNA methylation result from opposing enzymatic activitie

264 ategories, including chromatin modification, DNA methylation, RNA splicing, cohesin complex, transcri

265 uring DNA methylation, we aimed to develop a DNA methylation score that can be used on adolescent DNA

266 Further, three previously proposed DNA methylation scores were applied for comparison.

267 Our study shows that lineage-specific DNA methylation signatures are stably maintained during

268 human cohort data have revealed differential DNA methylation signatures in proxy tissues that are ass

269 ssociation studies identified the cg00574958 DNA methylation site at the carnitine palmitoyltransfera

270 We identified a set of 347 DNA methylation sites that, in combination, optimally pr

271 les as a model, we demonstrate that variable DNA methylation states at TEs are highly susceptible to

272 Here, we evaluated the DNA methylation status of patients with tuberculosis (TB

273 tion coupled with localized ectopic gains of DNA methylation that alter transcription.

274 urons contain uniquely high levels of non-CG DNA methylation that can be bound by the Rett syndrome p

275 mt3a and Dnmt3b to contribute to the de novo DNA methylation that governs early steps of ESC differen

276 scriptomic analyses to characterize sites of DNA methylation that influence genital development.

277 n gene expression, alternative splicing, and DNA methylation that may shape transcriptome complexity

278 Given well-defined changes in DNA methylation that occur during aging, rare variation

279 atin remodeler-associated modifications, and DNA methylation) that contribute to relapse to cocaine,

280 is required for the faithful propagation of DNA methylation throughout the cell cycle.

281 nstrates the functional impact of changes in DNA methylation to determine the colorectal cancer cell

282 Our study links DNA methylation to disease endpoints via intermediate pr

283 oduction, and the cell more strongly targets DNA methylation to TEs that have the potential to make m

284 Here, we integrated genome-wide DNA methylation, transcriptome, mutation, and phenotypic

285 We discuss this phenomenon and propose that DNA methylation turnover might facilitate key lineage de

286 he notion that epigenetic mechanisms such as DNA methylation underlie biological embedding, causal da

287 s reveal that histone modifications, but not DNA methylation, underlie exon-specific transcription of

288 ples from placenta (fetal side) and measured DNA methylation using Illumina EPIC arrays.

289 o investigate As exposure and locus-specific DNA methylation using the Illumina MethylationEPIC array

290 DNA methylation valleys exhibit elevated conservation an

291 argc1a promoter had a fetal origin; elevated DNA methylation was also detected in neonatal BAT and br

292 DNA methylation was assessed using Illumina HumanMethyla

293 We tested whether DNA methylation was associated with mortality in models

294 Mutually independent DNA methylation was associated with source-specific tran

295 Umbilical cord blood DNA methylation was evaluated using the Illumina HumanMe

296 DNA methylation was measured in 2,325 participants using

297 onchoscopy to collect epithelial cells whose DNA methylation was measured using the Illumina 450 K pl

298 With declining costs for measuring DNA methylation, we aimed to develop a DNA methylation s

299 deficiency disturbs the 1C cycle and alters DNA methylation which is vital for most metabolic proces

300 Mammalian DNA methylation, which mostly occurs in the context of C