ライフサイエンスコーパス: DNA polymerase

1 could destabilize the finger domain of UL54 DNA polymerase.

2 inator, but not by a host-like high fidelity DNA polymerase.

3 enzyme an efficient and faithful replicative DNA polymerase.

4 stranded logic gates using strand-displacing DNA polymerase.

5 these proteins, CCPol, is an active A-family DNA polymerase.

6 phates were not substrates for mitochondrial DNA polymerase.

7 te for both ceftolozane and ceftazidime, and DNA polymerase.

8 n of damaged DNA by recruiting lesion-bypass DNA polymerases.

9 demonstrated to be a mutagenic substrate for DNA polymerases.

10 short RNA primers which are then extended by DNA polymerases.

11 of the two metal ions in the specificity of DNA polymerases.

12 y future rational engineering of replicative DNA polymerases.

13 w the oxidized ribonucleotide is utilized by DNA polymerases.

14 or-rates of mutator versions of animal gamma DNA polymerases.

15 is suppressed in the catalytic site of most DNA polymerases.

16 ism of base selection in the Pol X family of DNA polymerases.

17 served in DinB, but not in other translesion DNA polymerases.

18 c substrate for insertion into the genome by DNA polymerases.

19 ues) is the largest catalytic subunit of the DNA polymerases.

20 insights into how r8-oxo-GTP is processed by DNA polymerases.

21 anges in Rev1 like those observed with other DNA polymerases.

22 Unlike gamma DNA polymerases, ablation of 3'-5' exonuclease function

23 however, DinB is the only known translesion DNA polymerase active in RecA-mediated strand exchange d

24 t requirements necessary to achieve a closed DNA polymerase active site poised for efficient nucleoti

25 niently, we find widespread NP-DNA-dependent DNA polymerase activity among reverse transcriptases, an

26 We show that DNA-dependent NP-DNA polymerase activity depends on conserved active site

27 onstrate redundancy of the Pol alpha-primase DNA polymerase activity in replication and show that Pol

28 Yeast Pole-P301R has increased DNA polymerase activity, which could underlie its high m

29 ine substitution is a dramatically increased DNA polymerase activity.

30 or together with a 5'-3' exonuclease for its DNA polymerase activity.

31 53BP1, RIF1, REV7-Shieldin (SHLD1-3) or CST-DNA polymerase alpha (Pol-alpha) in BRCA1-deficient cell

32 The catalytic subunit of DNA Polymerase alpha (Polalpha) has been implicated in t

33 r synthesis of an RNA-DNA oligonucleotide by DNA polymerase alpha holoenzyme, proliferating cell nucl

34 rature-sensitive allele of the gene encoding DNA polymerase alpha subunit 2 (pola2) that disrupts fin

35 The DNA polymerase alpha-primase complex performs limited sy

36 POLA1 encodes the p180 catalytic subunit of DNA polymerase alpha-primase.

37 present evidence that pol eta competes with DNA polymerases alpha and delta for the synthesis of the

38 nsible for leading strand synthesis, whereas DNA polymerases alpha and delta synthesize the lagging s

39 members of the B family of DNA polymerases: DNA polymerases alpha, delta, and epsilon.

40 The four B-family DNA polymerases alpha, delta, e and zeta cooperate to ac

41 e transcriptase without being substrates for DNA-polymerases alpha, beta, and gamma.

42 T, while they proved to be nonsubstrates for DNA-polymerases alpha, beta, and gamma.

43 ay associated with constitutional defects in DNA polymerase and mismatch repair (MMR) genes, and a mo

44 imase superfamily enzymes, PrimPol possesses DNA polymerase and primase activities that are important

45 replisome as an entity that freely exchanges DNA polymerases and displays intermittent coupling betwe

46 ew focuses on functional interaction between DNA polymerases and DNA ligases in the repair of single-

47 on frequencies in genes encoding replicative DNA polymerases and in genes frequently mutated in CRC,

48 ing advantage of the inherent specificity of DNA polymerases and ligases, coupled with volume restric

49 ta (PolH, Poleta) belongs to the Y-family of DNA polymerases and mediates DNA translesion synthesis,

50 and in the absence of this system, accessory DNA polymerases and MutY/M contribute to antibiotic-indu

51 , where it acts as an essential cofactor for DNA polymerases and other proteins.

52 o-GTP is a potential mutagenic substrate for DNA polymerases and provide structural insights into how

53 and-shaped" polymerase core domain shared by DNA polymerases and telomerases, our results show the fu

54 the chemistry and properties of replicative DNA polymerases and their evolved variants, focusing on

55 POLG (the catalytic subunit of mitochondrial DNA polymerase) and POLGARF synthesized from a single PO

56 son method utilizing T5 exonuclease, Phusion DNA polymerase, and DNA ligase.

57 We found that long-lived DNA interaction by DNA polymerase are more abundant upon DNA damage, sugges

58 Replicative DNA polymerases are highly efficient enzymes that mainta

59 DNA polymerases are today used throughout scientific res

60 analogs (CTNAs), which cannot be extended by DNA polymerases, are widely used as antivirals or anti-c

61 he structurally analogous side chain in RB69 DNA polymerase (Arg-482) and HIV reverse transcriptase (

62 s the central reaction in DNA replication by DNA polymerase as well as many other biological processe

63 gesting a mechanism of rNMP accommodation by DNA polymerases as a driving force of rNMP incorporation

64 rough probing cDNA extension mediated by Bst DNA polymerase at and near target cellular sites by sequ

65 enomes could be partially due to the loss of DNA polymerase B (polB) and methyladenine DNA glycosylas

66 combines human RNA bait-depletion with phi29 DNA polymerase-based multiple displacement amplification

67 To do this, here we employed human DNA polymerase beta (pol beta) and characterized r8-oxo-

68 Eukaryotic DNA polymerase beta (Pol beta) plays an important role i

69 DNA polymerase beta (pol beta) selects the correct deoxy

70 recruited to DNA lesions and associates with DNA polymerase beta (Pol beta) to function in DNA repair

71 lular impact of the T304I cancer mutation of DNA Polymerase beta (Polbeta), we find that mutation of

72 These results indicate that DNA polymerase beta can induce a strain in the DNA that

73 nucleotide incorporation and illustrate how DNA polymerase beta has evolved to hinder Fapy*dGTP inse

74 DNA polymerase beta has two DNA-binding domains that int

75 the incorporation of dGTP catalyzed by human DNA polymerase beta is not affected when 5-methylcytosin

76 E1 strand cleavage and stimulated subsequent DNA polymerase beta-gap filling activity by 30-fold.

77 ble Fapy*dGTP analog, beta-C-Fapy*dGTP, with DNA polymerase beta.

78 uplex DNA containing a one-nucleotide gap by DNA polymerase beta.

79 nesis, we conducted kinetic studies of human DNA polymerases beta and eta replicating across oxoA and

80 ) repair pathway, can directly interact with DNA polymerase-beta (Pol-beta), a central player in the

81 ial In-Fusion method employing a proprietary DNA polymerase, but higher than that of the Gibson metho

82 is cheaper, easier and avoids inhibition of DNA polymerase by molecules from the food matrices.

83 ity to evade the geometric discrimination of DNA polymerases by adopting Hoogsteen base pairing with

84 exchange reaches the 3' end of the ssDNA, a DNA polymerase can add nucleotides onto the end, using o

85 The evidence that a DNA polymerase can configure its active site entirely di

86 If not repaired in time, DNA polymerases can mispair Ade with 8-oxoG in the templ

87 nstitution experiments, we showed that human DNA polymerases can utilize RPA-generated R-loops for in

88 a-CXY-dNTPs) have provided information about DNA polymerase catalysis and fidelity.

89 DNA polymerase catalyzes the replication of DNA, one of

90 , dNTP depletion, and chemical inhibition of DNA polymerases cause excessive DNA unwinding by the rep

91 All patients routinely underwent weekly EBV DNA polymerase chain reaction monitoring and serum elect

92 When coupled to DNA polymerase, CMG remains on ssDNA, but when uncoupled

93 Barcoded DNA "polymerase colony" (polony) amplification technique

94 er cells following depletion of the B-family DNA polymerases combined with SRA737 treatment.

95 Here we identify subunits of the replicative DNA polymerase delta (Pol delta) as promoters of Alt-NHE

96 In eukaryotes, DNA polymerase delta (Pol delta) bound to the proliferat

97 DNA polymerase delta (Pol delta) initiates BIR; however,

98 DNA polymerase delta (Pol delta) is responsible for the

99 Although PCNA interacts with the enzymes DNA polymerase delta (Pol delta), flap endonuclease 1 (F

100 e of the main DNA replicases in human cells, DNA polymerase delta (Pol delta), with an error-prone va

101 a gene orthologous with the third subunit of DNA polymerase delta (POLD3), a previously uncharacteriz

102 on, molecular and functional analyses of the DNA polymerase delta (Poldelta) complex, and T- and B-ce

103 DNA polymerase delta (Poldelta) plays pivotal roles in e

104 creases strand-displacement DNA synthesis by DNA polymerase delta and allows DNA replication across a

105 Human DNA polymerase delta is essential for DNA replication an

106 g replication, here we present evidence that DNA polymerase delta universally participates in initiat

107 r antigen, the replication factor C complex, DNA polymerase delta, flap endonuclease 1 and DNA ligase

108 trand synthesis: The processivity subunit of DNA polymerase delta, Pol32, and the catalytic domain of

109 pears to regulate polymerase handoff, and in DNA polymerase delta, the redox switch provides a means

110 nerated via strand-displacement synthesis by DNA polymerase delta.

111 trand displacement DNA synthesis activity of DNA polymerase delta.

112 replication of undamaged DNA is conducted by DNA polymerases delta and epsilon.

113 s form barriers to nuclear and mitochondrial DNA polymerases delta and gamma, respectively.

114 We sought to establish the role of DNA polymerase delta1 catalytic subunit (POLD1) as the c

115 is task are three members of the B family of DNA polymerases: DNA polymerases alpha, delta, and epsil

116 xonuclease domain (FEN/EXO) and a C-terminal DNA polymerase domain (POL).

117 rocess of slipped strand mispairing (SSM) by DNA polymerase during replication.

118 investigate the effects of cancer-associated DNA polymerase e (Pole) mutations on tumorigenesis and r

119 Substitutions in the exonuclease domain of DNA polymerase e cause ultramutated human tumors.

120 xposes a remarkable co-evolution scenario of DNA polymerase enzyme kinetics with dNTP levels that can

121 DNA polymerase epsilon (Pol epsilon) is required for gen

122 most frequently recurring cancer-associated DNA polymerase epsilon (Pol epsilon) mutation is a P286R

123 lfur cluster (ISC) biosynthesis and identify DNA polymerase epsilon (POLE) as an ISC-containing prote

124 clease domain mutations in the gene encoding DNA polymerase epsilon (POLE) have incredibly high mutat

125 Molecular subtypes of EC were assigned using DNA polymerase epsilon (POLE) hotspot mutations and immu

126 Alterations in the exonuclease domain of DNA polymerase epsilon (Polepsilon) cause ultramutated t

127 In eukaryotic DNA replication, DNA polymerase epsilon (Polepsilon) is responsible for l

128 ana mutant of the POL2A catalytic subunit of DNA polymerase epsilon and show that POL2A is required t

129 During eukaryotic replication, DNA polymerases epsilon (Polepsilon) and delta (Poldelta

130 ion domain substitution raised the organelle DNA polymerase error rate by 140-fold relative to the wi

131 However, errors before UMI tagging, such as DNA polymerase errors during end repair and the first PC

132 Similar observations with two other DNA polymerases establish its generality.

133 anslesion synthesis (TLS), mediated by human DNA polymerase eta (hpol eta), and on RNase H2-mediated

134 Recruitment of DNA polymerase eta (Pol eta) and other Y-family TLS poly

135 DNA polymerase eta (pol eta) is best known for its abili

136 Interestingly, human DNA polymerase eta (poleta) proficiently incorporates dG

137 acetylation of Poliota's closest paralogue, DNA polymerase eta (Poleta), with which Poliota shares m

138 DNA polymerase eta (PolH, Poleta) belongs to the Y-famil

139 Here we use extensive simulations of DNA polymerase eta to test mechanistic hypotheses.

140 ytidine deaminase (AID) and the A-T mutator, DNA polymerase eta, respectively, in mutagenesis in norm

141 We have used yeast DNA polymerases eta, zeta and Rev1 to study translesion

142 freading exonuclease activity of replicative DNA polymerase excises misincorporated nucleotides durin

143 -barrel catalytic core absent from all other DNA polymerase families but found in RNA polymerases (RN

144 In all other DNA polymerase families, an active site steric gate resi

145 However, DNA polymerase fidelity is unaltered when these modifica

146 ional changes are of critical importance for DNA polymerase fidelity within specific DNA sequence con

147 g incorporation of 8-oxoG opposite to Ade by DNA polymerases following adduct formation.

148 lymerase (PolD) is the essential replicative DNA polymerase for duplication of most archaeal genomes.

149 form, PCNA recruits a set of damage-tolerant DNA polymerases for translesion synthesis.

150 Pol gamma is the only DNA polymerase found in mitochondria for most animal cel

151 y challenging the notion that lagging-strand DNA polymerases frequently dissociate from replisomes du

152 primers are, in fact, slowly extended by the DNA polymerase from B. stearothermophilus in a template-

153 DNA polymerase from bacteriophage T7 undergoes large, su

154 stochastic uncoupling of the leading-strand DNA polymerase from the replication fork DNA helicase, a

155 purified Pol establishes a new paradigm for DNA polymerase function.

156 mpeded the processivity of the mitochondrial DNA polymerase gamma (Pol gamma) in vitro, providing a p

157 is of off-target inhibition of mitochondrial DNA polymerase gamma (Polgamma).

158 incorporated in vitro by HIV-1 RT and human DNA polymerase gamma and did enable specific HIV-1 DNA l

159 These patterns implicate replication by DNA polymerase gamma as the deletion driver and suggest

160 DNA polymerase gamma is a core component of the mtDNA re

161 ocated on nuclear chromosome 15, encodes the DNA polymerase gamma(Pol gamma).

162 talytic subunit of replicative mitochondrial DNA polymerase gamma.

163 distinct from those previously reported with DNA polymerase genes were evident, highlighting differin

164 Mutations affecting DNA polymerases have been implicated in genomic instabil

165 modifying enzymes (Taq DNA polymerase, Phi29 DNA polymerase) have been widely used for the diagnosis

166 hrough the 3'-5' exonuclease activity of the DNA polymerase holoenzyme.

167 erved when other translesion synthesis (TLS) DNA polymerases-hpol iota, kappa, or zeta-were individua

168 t enzyme action depends on replication mode: DNA Polymerase I (PolI)-dependent ColE1 and p15A origins

169 nd, the highly homologous Klenow fragment of DNA polymerase I containing an engineered gp5 thioredoxi

170 gorithms and reanalyzed experimental data of DNA polymerase I diffusing in live Escherichia coli.

171 that the efficiency of primer processing by DNA polymerase I in vitro is specifically affected by th

172 n by examining the structure and dynamics of DNA polymerase I Klenow Fragment (Pol) substrates both a

173 is paradigm, a naturally occurring bacterial DNA polymerase I member isolated from Geobacillus stearo

174 good efficiency with the Klenow fragment of DNA polymerase I, and we identify thermostable enzymes t

175 sions was not dependent on the activities of DNA polymerases II, IV, or V; Ada, a protein involved in

176 toward the beta subunit of Escherichia coli DNA polymerase III holoenzyme by mutation of a phenylala

177 ur SIPs (RecO, PriC, PriA and chi subunit of DNA polymerase III) of three peptides containing the aci

178 triphosphate was a good substrate for KOD XL DNA polymerase in primer extension synthesis of modified

179 f dATP into a primed DNA template by the EBV DNA polymerase in vitro.

180 coli SOS DNA-damage response and error-prone DNA polymerases in all cells.

181 , we examined a possible role of replicative DNA polymerases in their bypass and determined that hPol

182 niscent of naturally occurring RNA-dependent DNA polymerases, including telomerase, which have a dram

183 Also, little is known about DNA polymerases incorporating oxidized nucleotides in ce

184 notyped as conferring resistance to standard DNA polymerase inhibitor(s), including K493N, P497S, K51

185 phosphonoformic acid (PFA), a reversible HBV DNA polymerase inhibitor, at the stage of single-strande

186 further demonstrated that treatment with the DNA-polymerase inhibitor aphidicolin diminishes cccDNA f

187 d, free 8-oxo-dGTP can be misincorporated by DNA polymerases into DNA opposite template Ade.

188 The error prone organelle DNA polymerase introduced mutations at multiple location

189 To identify DNA polymerases involved in DpC bypass, we comparatively

190 Here, we report that DNA polymerase iota (Pol iota) is a novel USP7 substrate

191 DNA polymerase iota (Poliota) belongs to the Y-family of

192 he interesting question of how a replicative DNA polymerase is able to recognize templates of diverse

193 proposed function of Pol zeta as an extender DNA polymerase is also required for ICL repair.

194 For an in vitro assembly reaction, a DNA polymerase is often used either alone for its 3'-5'

195 n skin cancer formation, we determined which DNA polymerase is responsible for generating UV mutation

196 Proofreading by replicative DNA polymerases is a fundamental mechanism ensuring DNA

197 DNA synthesis (TLS) mediated by low-fidelity DNA polymerases is an essential cellular mechanism for b

198 ds developed in this study are recognized by DNA polymerases is important in view of the future selec

199 G), when produced in situ or incorporated by DNA polymerases, is highly mutagenic due to mispairing w

200 arily conserved Escherichia coli translesion DNA polymerase IV (DinB) is one of three enzymes that ca

201 inding processes of the multidomain Y-family DNA polymerase IV (DPO4).

202 have been proposed for the Escherichia coli DNA polymerase IV (pol IV).

203 ants, focusing on the Klenow fragment of Taq DNA polymerase (Klentaq).

204 NA duplexes, and within the active site of a DNA polymerase lambda variant.

205 ase (Pol) IV and the more rapid extension by DNA polymerase LF-Bsu We found that when DNA Pol IV exte

206 the mtDNA replisome and the only replicative DNA polymerase localized to mitochondria.

207 NRTI-sensitive DNA polymerases localizing to mitochondria allow for the

208 Translesion DNA polymerases may also contribute.

209 During DNA replication, replicative DNA polymerases may encounter DNA lesions, which can sta

210 notion that the substrate channeling during DNA polymerase-mediated nucleotide insertion coupled to

211 A-PDS conjugate stopped the replication of a DNA polymerase more efficiently than PA or PDS.

212 u, X4L4, and XLF, it has been suggested that DNA polymerase mu (pol mu) may also align two dsDNA ends

213 DNA polymerase mutations can cause hypermutant cancers,

214 s of tumorigenesis and the impact of various DNA polymerase mutations on treatment response is poorly

215 ntial to be highly mutagenic because it uses DNA polymerases, nucleases, and other enzymes that modif

216 Ribonucleotide incorporation by eukaryotic DNA polymerases occurs during every round of genome dupl

217 -with the peptides that are derived from the DNA polymerase of herpes simplex virus 1 (Pol peptides).

218 In isolation, gp5 is a DNA polymerase of low processivity.

219 orporated opposite DNA adducts by engineered DNA polymerases offers a potential basis for site-specif

220 Here especially, natural DNA polymerases often do not have the "performance speci

221 the human mitochondrial and bacteriophage T7 DNA polymerases on free-ssDNA, in comparison with ssDNA

222 Recently, DNA-modifying enzymes (Taq DNA polymerase, Phi29 DNA polymerase) have been widely u

223 There is evidence that DNA polymerases play a role in transcriptional silencing

224 nd exonuclease states of E. coli replicative DNA polymerase Pol III.

225 High fidelity human mitochondrial DNA polymerase (Pol gamma) contains two active sites, a

226 DNA polymerase (pol) beta catalyzes two reactions at DNA

227 DNA polymerase (Pol) beta is a key enzyme in base excisi

228 atalyze the ultimate ligation step following DNA polymerase (pol) beta nucleotide insertion during ba

229 The DNA polymerase (Pol) delta of Saccharomyces cerevisiae (

230 The eukaryotic leading strand DNA polymerase (Pol) epsilon contains 4 subunits, Pol2,

231 ension of the invading strand in a D-loop by DNA polymerase (Pol) IV and the more rapid extension by

232 DNA polymerase (pol) mu primarily inserts ribonucleotide

233 mplate strand cause the high-fidelity (HiFi) DNA polymerase (Pol) to stall.

234 Eukaryotic DNA polymerase (Pol) X family members such as Pol mu and

235 hat DNA synthesis by two known mitochondrial DNA polymerases (Pol gamma, PrimPol) in vitro was strong

236 ne process is translesion synthesis (TLS) by DNA polymerases (Pol) delta, eta and zeta, which creates

237 of ribonucleoside monophosphates (rNMPs) by DNA polymerases (Pol) into DNA.

238 and two subunits shared with the replicative DNA polymerase, pol delta.

239 utational inactivation of the leading strand DNA polymerase, Pol epsilon, dNTP depletion, and chemica

240 We identified subunits of the B-family of DNA polymerases (POLA1, POLE, and POLE2) whose silencing

241 Bacillus subtilis cells: the two replicative DNA polymerases, PolC and DnaE, and a processivity clamp

242 Family D DNA polymerase (PolD) is the essential replicative DNA p

243 report that up-regulation of the translesion DNA polymerase Polkappa mediates resistance to BRAF path

244 The DNA polymerase Polkappa plays a key role in translesion

245 replicative and translesion synthesis (TLS) DNA polymerases (Pols) are retained in their cellular ro

246 DNA polymerases (Pols) provide roles in both replication

247 ial with four Y-family translesion synthesis DNA polymerases (pols): human pol (hpol) eta, hpol kappa

248 merases display much higher K(m) values than DNA polymerases, possibly due to millimolar range rNTP c

249 dvances have not been made for the organelle DNA polymerases present in plant mitochondria and chloro

250 rimPol is the most recently discovered human DNA polymerase/primase and plays an emerging role in nuc

251 nd (Polepsilon) or lagging strand (Poldelta) DNA polymerase proofreading.

252 rface plasmon resonance (LSPR) to detect the DNA-polymerase reaction in real-time.

253 NDPs with RNAP along with those reported for DNA polymerases reinforces the hypothesis that NDPs may

254 A novel family of DNA polymerases replicates organelle genomes in a wide d

255 dynamics in specificity for a high-fidelity DNA polymerase responsible for genome replication.

256 The Y-family DNA polymerase REV1 completes repair of the crosslink, c

257 Making error-prone mutator versions of gamma DNA polymerases revolutionised our understanding of anim

258 s of human single-strand DNA nuclease TREX2, DNA polymerases, RNA, and RNA:DNA nucleases.

259 Previously, we evolved a DNA polymerase, SFM4-3, for the recognition of substrate

260 rus reverse transcriptase (HIV-RT) and three DNA-polymerases showed a high selectivity of these gamma

261 y diverse, their repetitive sequences induce DNA polymerase slippage and stalling, leading to length

262 We demonstrate that DNA polymerase stalling at DNA structures induces error-

263 zyme in vitro make the error prone organelle DNA polymerase suitable for elevating mutation rates in

264 The POLG gene encodes the mitochondrial DNA polymerase that is responsible for replication of th

265 theta, gene name Polq) is a widely conserved DNA polymerase that mediates a microhomology-mediated, e

266 merase and the 5'->3' nuclease domain of Taq DNA polymerase that provided compatibility with probe-ba

267 se iota (Poliota) belongs to the Y-family of DNA polymerases that are involved in DNA damage toleranc

268 By using alleles of the replicative DNA polymerases that are permissive for ribonucleotide i

269 Bacteriophage T7 encodes its own DNA polymerase, the product of gene 5 (gp5).

270 Unique among DNA polymerases, the Pol3 catalytic subunit contains a 4

271 ecent evidence suggests that in Arabidopsis, DNA polymerase theta (PolQ) may be a crucial enzyme invo

272 d end-joining (TMEJ) pathway, which requires DNA polymerase theta (POLtheta) encoded by the POLQ gene

273 DNA polymerase theta (Poltheta) is a unique polymerase-h

274 In this regard, DNA polymerase theta differs from other Pols in that whe

275 DNA polymerase theta mediates an end joining pathway (TM

276 Recent studies have implicated DNA polymerases theta (Pol theta) and beta (Pol beta) as

277 Occasional jumps of DNA polymerase through this triplex hurdle, result in re

278 ny enzymes and contribute to the fidelity of DNA polymerases through a two-metal ion mechanism.

279 ng the function of this putative translesion DNA polymerase to host immune evasion by antigenic varia

280 Higher tolerance of Phusion hot start DNA polymerase to PCR inhibitors and its compatibility w

281 how that the response of a model replicative DNA polymerase to variously structured DNA is sufficient

282 nd breaks would allow entry for low-fidelity DNA polymerases to generate somatic hypermutation.

283 sis suggests the contribution of error-prone DNA polymerases to the latter signatures.

284 so results in the recruitment of error-prone DNA polymerases to the replication fork.

285 how changing local concentrations of the key DNA polymerases tunes the ability of the complex to effi

286 fidelities of error prone tobacco organelle DNA polymerases using a novel positive selection method

287 Moreover, pharmacologic blockade of B-family DNA polymerases using aphidicolin or CD437 combined with

288 Activation of the bacterial lesion bypass DNA polymerase V (Pol V) requires both the cleavage of t

289 reatment, and the involvement of error-prone DNA polymerase V (UmuDC).

290 ns distant from the active site in a Klentaq DNA polymerase variant (ZP Klentaq) contribute to its ab

291 pped-flow and rapid-quench methods with a T7 DNA polymerase variant containing a fluorescent unnatura

292 dNTPalphaSe can be efficiently recognized by DNA polymerases, while the other is neither a substrate

293 The use of a Phusion hot start DNA polymerase with a high tolerance to possible PCR inh

294 are removed from ssDNA by the lagging strand DNA polymerase without compromising the advance of the r

295 DNA polymerase zeta (Pol zeta) and Rev1 are essential fo

296 Here, we survey the diverse functions of DNA polymerase zeta (pol zeta) in eukaryotes.

297 requires reverse transcriptase, translesion DNA polymerase zeta (Pol zeta) plays a major role in R-T

298 DNA polymerase zeta (Polzeta) belongs to the same B-fami

299 During translesion synthesis, eukaryotic DNA polymerase zeta (zeta) carries out extension from a

300 ed MNV mutational signatures associated with DNA polymerase zeta, an error-prone translesion polymera