ライフサイエンスコーパス: DNA polymerase alpha

1 mponent of a B family DNA polymerase member, DNA polymerase alpha.

2 cation including DHFR, thymidine kinase, and DNA Polymerase alpha.

3 zed several temperature-sensitive mutants of DNA polymerase alpha.

4 h chromatin is dependent on RNA synthesis by DNA polymerase alpha.

5 duced expression of the catalytic subunit of DNA polymerase alpha.

6 proteins, the origin recognition complex and DNA polymerase alpha.

7 Pol1p promotes C(1-3)A strand resynthesis by DNA polymerase alpha.

8 continuous DNA synthesis was attributable to DNA polymerase alpha.

9 chia coli DNA polymerase I or by calf thymus DNA polymerase alpha.

10 er is sufficient for extension with dNTPs by DNA polymerase alpha.

11 xDNA uncovered a gene encoding a subunit of DNA polymerase alpha.

12 was inhibited by neutralizing antibodies to DNA polymerase alpha.

13 pin loop in the template and dissociation of DNA polymerase alpha.

14 e replication without causing degradation of DNA polymerase alpha.

15 Mcm2-7 DNA helicase at replication forks to DNA polymerase alpha.

16 ts of the RPC is crucial to couple MCM2-7 to DNA polymerase alpha.

17 on of the error-prone synthesis catalyzed by DNA polymerase alpha.

18 xpression of Pol1p, the catalytic subunit of DNA polymerase alpha.

19 a180, which encodes the catalytic subunit of DNA polymerase alpha.

20 p58, and is normally tightly associated with DNA polymerase alpha.

21 actin I, alpha-telomere binding protein, and DNA polymerase alpha.

22 OLA1, which encodes the catalytic subunit of DNA polymerase-alpha.

23 th an antibody that specifically neutralized DNA polymerase alpha activity.

24 yotes, but instead functions like eukaryotic DNA polymerase alpha, adding a stretch of deoxynucleotid

25 We have used DNA polymerase alpha affinity chromatography to identify

26 Low levels of DNA polymerase-alpha also induced very high rates of ane

27 Hypotrich phylogenies based on DNA polymerase alpha amino acid sequences are incongruen

28 Phylogenetic relationships inferred from DNA polymerase alpha amino acid sequences have been used

29 pe 1 reverse transcriptase but not for human DNA polymerase alpha and beta.

30 ant effect on the synthetic ability of human DNA polymerase alpha and delta by Tim-Tipin was observed

31 xposure to aphidicolin, an inhibitor of both DNA polymerase alpha and delta, results in a reproducibl

32 Furthermore, the addition of DNA polymerase alpha and deoxynucleoside triphosphates t

33 olin at concentrations specific for blocking DNA polymerase alpha and dideoxynucleotide triphosphates

34 rmine if two B family DNA polymerases, human DNA polymerase alpha and herpes simplex virus I DNA poly

35 eukaryotic primases that form a complex with DNA polymerase alpha and its accessory B subunit.

36 nd 1,3-diaza-2-oxophenoxazine (tCo) by human DNA polymerase alpha and Klenow fragment of DNA polymera

37 treatment with aphidicolin, an inhibitor of DNA polymerase alpha and other polymerases.

38 lular proteins to the origin, including host DNA polymerase alpha and replication protein A.

39 for the initiation of SV40 DNA replication, DNA polymerase alpha and SV40 large T antigen.

40 T antigen, DNA polymerase alpha and the activation domain of VP16 a

41 wn-regulated by miR-206, the p180 subunit of DNA polymerase alpha and three other genes are shown to

42 g Asf1p are highly sensitive to mutations in DNA polymerase alpha and to DNA replicational stresses.

43 ntrol the onset of DNA synthesis mediated by DNA polymerase-alpha and its intrinsic RNA primase activ

44 fragment of DNA polymerase I, DNA Sequence, DNA polymerase-alpha and polymerase-beta, as well as HIV

45 ore helicase, the lagging strand polymerase, DNA polymerase-alpha and the replication clamp, prolifer

46 We demonstrated a requirement for DNA polymerases alpha and beta in repair of both photopr

47 Mammalian DNA polymerases alpha and beta lack 3' exonuclease activ

48 transcriptases and compared them to those of DNA polymerases alpha and beta.

49 titive inhibition studies indicate that like DNA polymerases alpha and delta (pol alpha and pol delta

50 permitted us to determine that the essential DNA polymerases alpha and delta and DNA primase were req

51 DNA polymerases alpha and delta carry out the initiation

52 present evidence that pol eta competes with DNA polymerases alpha and delta for the synthesis of the

53 nsible for leading strand synthesis, whereas DNA polymerases alpha and delta synthesize the lagging s

54 DNA at an origin of replication, stimulates DNA polymerases alpha and delta, and supports the format

55 The MRC were shown to contain DNA polymerases alpha and delta, DNA primase, DNA helica

56 onents involved in lagging strand synthesis, DNA polymerases alpha and delta, have substantially redu

57 of archaeal DNA polymerase II and eukaryotic DNA polymerases alpha and delta, is shown to belong to t

58 xpected, the 3dMeA lesion blocked both human DNA polymerases alpha and delta.

59 at contains Mrc1, Tof1, MCM-Cdc45, GINS, and DNA polymerases alpha and epsilon and that recruits the

60 However, due to the presence of DNA polymerases alpha and epsilon in the depleted extrac

61 bstantially blocked further DNA synthesis by DNA polymerases alpha and epsilon in vitro, indicating a

62 edly stimulates the polymerase activities of DNA polymerases alpha and epsilon in vitro.

63 Replisome passage is primarily aided by DNA polymerases alpha and epsilon, a finding that necess

64 polymerase delta but was free of detectable DNA polymerases alpha and epsilon.

65 extending DNA strand catalyzed by both human DNA polymerases alpha and epsilon.

66 ase are dependent on RNA primer synthesis by DNA polymerase alpha, and it has been suggested that the

67 ut5 was required for the recruitment of Atr, DNA polymerase alpha, and Rad1 but not RPA to chromatin

68 the progression of S-phase, such as DHFR and DNA polymerase alpha, and they play a critical role in c

69 origin unwinding and the loading of RPA and DNA polymerase alpha are also inhibited.

70 luding CDK2, Cdc7, and Cdc45, but not RPA or DNA polymerase alpha, are necessary for activating the d

71 DNA polymerase alpha association is similarly delayed at

72 primarily blocked replication by calf thymus DNA polymerase alpha at the modified base, while human p

73 r extension reactions catalyzed by mammalian DNA polymerases alpha, beta, and delta.

74 r extension reactions catalyzed by mammalian DNA polymerases alpha, beta, and delta.

75 y primer extension in reactions catalyzed by DNA polymerases alpha, beta, and delta.

76 (as measured by DNA polymerase activity) of DNA polymerases alpha, beta, delta (+/- PCNA) and straig

77 These SLE sera did not inhibit the DNA polymerases alpha, beta, gamma and had no antibody t

78 T, while they proved to be nonsubstrates for DNA-polymerases alpha, beta, and gamma.

79 e transcriptase without being substrates for DNA-polymerases alpha, beta, and gamma.

80 ha does not, indicating that Cdc45, RPA, and DNA polymerase alpha bind chromatin sequentially at the

81 ituents of the replication fork, such as the DNA polymerase alpha-binding protein Ctf4, contribute to

82 ylation of RPA disrupts the interaction with DNA polymerase alpha but has no significant effect on th

83 DNA polymerase alpha, but not T antigen also interacted

84 d through S phase; and (b) the inhibition of DNA polymerase alpha by aphidicolin-blocked DNA damage.

85 Here, we show that both Klenow fragment and DNA polymerase alpha can utilize 8-oxodGTP and incorpora

86 and (ii) flexible tethering of p58C and the DNA polymerase alpha catalytic core domain (p180core) to

87 NA replication gene: the structural gene for DNA polymerase alpha (cdc17/pol1).

88 of the four yeast family B DNA polymerases, DNA polymerase alpha, delta, epsilon or zeta, results in

89 res, interacts directly with the replicative DNA polymerases (alpha, delta, and epsilon), and markedl

90 nriched with replication proteins, including DNA polymerases (alpha, delta, etc.), was isolated, whic

91 MCM-GINS (CMG) replicative DNA helicase with DNA polymerases alpha, delta, and epsilon and other prot

92 the efficiencies with which the replicative DNA polymerases alpha, delta, and epsilon incorporated t

93 Accurate DNA synthesis by the replicative DNA polymerases alpha, delta, and epsilon is critical fo

94 members of the B family of DNA polymerases: DNA polymerases alpha, delta, and epsilon.

95 The four B-family DNA polymerases alpha, delta, e and zeta cooperate to ac

96 h alanine in the catalytic subunits of yeast DNA polymerases alpha, delta, epsilon, and zeta and exam

97 Aphidicolin, an inhibitor of DNA polymerase alpha, did not prevent camptothecin-induc

98 e (TAK)1, TAB1, c-FOS, DNA topoisomerase II, DNA polymerase alpha, dihydrofolate reductase, thymidine

99 gene encoding the large catalytic subunit of DNA polymerase alpha (DNA pol alpha) in the ciliate Oxyt

100 roximately 40 proteins of the MRC, including DNA polymerase alpha (DNA pol alpha), DNA topoisomerase

101 No evidence for the binding of DNA polymerase alpha, DNA ligase I or topoisomerase II w

102 including MCM complex members, DNA primase, DNA polymerase alpha, DNA ligase, and replication factor

103 , some of which were further confirmed to be DNA polymerase alpha, DNA topoisomerase I, and PCNA by i

104 prevented, Cdc45 binds to chromatin whereas DNA polymerase alpha does not, indicating that Cdc45, RP

105 Macronuclear DNA clones of DNA polymerase alpha encoding approximately 1000 amino a

106 Human DNA polymerase alpha extended DNA primers terminated by

107 This ternary complex structure in the human DNA polymerase alpha family shows a 60 degrees rotation

108 DNA polymerase-alpha fits this purpose exactly, but litt

109 roliferating cell nuclear antigen (PCNA) and DNA polymerase alpha from replication forks.

110 eptide was able to displace the Ctf4 partner DNA polymerase alpha from the replisome in yeast extract

111 ation of a 5'-3' exonuclease associated with DNA polymerase alpha from the yeast Saccharomyces cerevi

112 lagging-strand DNA synthesis by facilitating DNA polymerase alpha function at replication forks.

113 synthesizes short RNA oligonucleotides that DNA polymerase alpha further elongates in order to initi

114 A primase synthesizes short RNA primers that DNA polymerase alpha further elongates.

115 ort the complex pattern of scrambling in the DNA polymerase alpha gene of Stylonychia lemnae.

116 An example is the extensively scrambled DNA polymerase alpha gene that is broken into 48 pieces

117 The complete macronuclear DNA polymerase alpha gene, previously sequenced in Oxytr

118 lex phenomenon during evolution, we examined DNA polymerase alpha genes in several earlier diverging

119 response only after the DNA was unwound and DNA polymerase alpha had been loaded.

120 r synthesis of an RNA-DNA oligonucleotide by DNA polymerase alpha holoenzyme, proliferating cell nucl

121 e of ara-C and CdA on DNA extension by human DNA polymerase alpha in an in vitro model system was con

122 M helicase enhance the physical stability of DNA polymerase alpha in the absence of their presumed li

123 Our results demonstrate a role of DNA polymerase alpha in the establishment of silencing.

124 on protein (PRP) complex that interacts with DNA polymerase alpha in the lagging strand of DNA during

125 also show that aRPA stimulates synthesis by DNA polymerase alpha in the presence of PCNA and RFC.

126 d other heterochromatin loci, interacts with DNA polymerase alpha in vivo and in vitro in wild type c

127 induced by reduced levels of the replicative DNA polymerase-alpha in the yeast Saccharomyces cerevisi

128 inhibitor of and only slowly polymerized by DNA polymerase alpha, indicating that it is a specific p

129 s been carried out on the clamp-loader-clamp-DNA polymerase alpha interactions in Escherichia coli, t

130 In addition, the interaction site for DNA polymerase alpha is composed of two functionally dis

131 hat are involved in chromosomal replication, DNA polymerase alpha is essential for initiation of repl

132 ally limited, it increases dramatically when DNA polymerase alpha is inhibited, indicating that the h

133 Because the fidelity of DNA polymerase alpha is lower than that of the DNA polym

134 Saccharomyces cerevisiae and functions as a DNA polymerase alpha loading factor in Xenopus, but its

135 These data suggest that DNA polymerase alpha may be able to rejoin double-strand

136 We also report that HJs accumulate in a DNA polymerase alpha mutant that lacks Mus81, providing

137 cause of telomere elongation in cdc17/pol1 (DNA polymerase alpha) mutants, we examined telomeric chr

138 Both the cdc13-5 mutation and DNA polymerase alpha mutations (which also exhibit elong

139 Cdc45p is required for recruiting DNA polymerase alpha onto chromatin, and it associates w

140 ibited by compounds that selectively inhibit DNA polymerase alpha or topoisomerase II, the enzymes re

141 al independent antibodies specific to either DNA polymerases alpha or beta and then restoring repair

142 oes not stimulate the activity of eukaryotic DNA polymerases alpha or epsilon, or a variety of other

143 CDK2 substrates such as RB, histone H1, and DNA polymerase alpha (p70 subunit) is reduced in the pre

144 Curiously, human DNA polymerase alpha (p70-p180 or p49-p58-p70-p180), whi

145 embly and cell cycle entry into S phase, and DNA polymerase-alpha, PCNA, and ribonucleotide reductase

146 In contrast, DNA polymerase alpha (Pol alpha) accumulates to higher t

147 In fission yeast both DNA polymerase alpha (pol alpha) and delta (pol delta) a

148 analogues and tested them as substrates for DNA polymerase alpha (pol alpha) and Klenow fragment (ex

149 We show aRPA has weakened interaction with DNA polymerase alpha (pol alpha) and that aRPA is not ab

150 We have found that human DNA polymerase alpha (pol alpha) and the Klenow fragment

151 After primase synthesizes a primer that DNA polymerase alpha (pol alpha) can readily elongate, f

152 tal structure of the catalytic core of human DNA polymerase alpha (Pol alpha) in the ternary complex

153 lear DNA replication, proofreading-deficient DNA polymerase alpha (Pol alpha) initiates Okazaki fragm

154 Klenow fragment exo- (Kf exo-), calf thymus DNA polymerase alpha (pol alpha) or human DNA polymerase

155 nks the Cdc45-MCM-GINS (CMG) DNA helicase to DNA polymerase alpha (Pol alpha) within the replisome.

156 with mutagenic bases, we examined how human DNA polymerase alpha (pol alpha), a B family enzyme, and

157 ow the initiator primase-polymerase complex, DNA polymerase alpha (pol alpha), is brought to the orig

158 rying temperature-sensitive alleles of PCNA, DNA polymerase alpha (Pol alpha), or primase showed that

159 is secured by its physical association with DNA polymerase alpha (Pol alpha), which extends the RNA

160 based on the logic that errors made by yeast DNA polymerase alpha (Pol alpha), which initiates Okazak

161 n of several replication proteins, including DNA polymerase alpha (pol alpha), with chromatin.

162 ity is mediated through the Pol12 subunit of DNA polymerase alpha (Pol alpha).

163 The DNA Polymerase alpha (Pol alpha)/primase complex initiat

164 Here, we show that a mutation in DNA polymerase alpha (pol(alpha)) affects Swi6 localizat

165 hich forms a projection, specifically blocks DNA polymerase alpha (Pol-alpha) and Ctf4 recruitment wi

166 53BP1, RIF1, REV7-Shieldin (SHLD1-3) or CST-DNA polymerase alpha (Pol-alpha) in BRCA1-deficient cell

167 s been shown to interact physically with the DNA polymerase-alpha (pol-alpha).primase complex.

168 s-1 reverse transcriptase (HIV RT) and human DNA polymerases alpha (pol alpha), beta (pol beta), gamm

169 abasic lesions on both primase activity and DNA polymerase alpha- (pol alpha) catalyzed elongation o

170 teins that bound to the catalytic subunit of DNA polymerase alpha (Pol1 protein) are encoded by the e

171 ngly, mutants of lagging strand replication, DNA polymerase alpha (pol1-17), DNA primase (pri2-1), an

172 n vivo and in vitro, to the large subunit of DNA polymerase alpha, POL1, requires the carboxyl-proxim

173 nd genetically with the catalytic subunit of DNA polymerase alpha, Pol1.

174 nteracted with both the catalytic subunit of DNA polymerase alpha, Pol1p, and the telomerase RNA-asso

175 nstrate that C-strand fill-in is mediated by DNA polymerase alpha (polalpha) and controlled by cyclin

176 Human DNA polymerase alpha (Polalpha) does not possess proofre

177 The catalytic subunit of DNA Polymerase alpha (Polalpha) has been implicated in t

178 DNA polymerase alpha (Polalpha) is essential for DNA rep

179 es the RNA primer, which is then extended by DNA polymerase alpha (Polalpha) to synthesize an initiat

180 osome, a four-subunit complex of primase and DNA polymerase alpha (Polalpha), initiates DNA synthesis

181 e, a four-subunit complex of DNA primase and DNA polymerase alpha (Polalpha), plays a critical role i

182 ome, a 340-kilodalton complex of primase and DNA polymerase alpha (Polalpha), synthesizes chimeric RN

183 osome, a four-subunit complex of primase and DNA polymerase alpha (Polalpha), synthesizes chimeric RN

184 ith the principal initiation DNA polymerase, DNA polymerase alpha (Polalpha).

185 required to maintain steady-state levels of DNA polymerase-alpha (polalpha).

186 at telomeres earlier than the lagging strand DNA polymerases alpha (Polalpha) and delta (Poldelta).

187 NA-DNA hybrid primers synthesized by primase-DNA polymerase alpha (Prim-Pol alpha) are needed to star

188 eplication in vitro at low concentrations of DNA polymerase-alpha primase (Pol-primase), and the p58

189 r (AAF) complex, stimulating the activity of DNA polymerase-alpha primase, the only enzyme known to i

190 cilitate the switch to C-strand synthesis by DNA polymerase alpha-primase (pol a-primase).

191 can only occur during G1; the recruitment of DNA polymerase alpha-primase (pol alpha) to chromatin.

192 The recruitment of DNA polymerase alpha-primase (pol-prim) is a crucial ste

193 DNA polymerase alpha-primase (pol-prim) is a heterotetra

194 DNA polymerase alpha-primase (pol-prim) plays a central

195 DNA polymerase alpha-primase (Pol-prim) plays an essenti

196 cellular proteins, replication protein A and DNA polymerase alpha-primase (pol-prim), constituting th

197 the DNA polymerases Poldelta and Polepsilon, DNA polymerase alpha-primase (Polalpha) and accessory pr

198 The B-subunit (p70/Pol12p) of the DNA polymerase alpha-primase (Polalpha-primase) complex

199 All other replication proteins, including DNA polymerase alpha-primase (polalpha-primase), are der

200 lomerase and complementary strand fill-in by DNA polymerase alpha-primase (polalpha-primase).

201 The CST (CTC1-STN1-TEN1) protein complex, a DNA polymerase alpha-primase accessory factor(4,5), is k

202 show that phosphorylation of purified human DNA polymerase alpha-primase by purified cyclin A/cdk2 i

203 The DNA polymerase alpha-primase complex forms an essential

204 The DNA polymerase alpha-primase complex performs limited sy

205 different cellular replication proteins, the DNA polymerase alpha-primase complex, the replication pr

206 tro primer extension assay and the mammalian DNA polymerase alpha-primase complex, we have observed a

207 uman genome is accomplished primarily by the DNA polymerase alpha-primase complex, which makes the RN

208 iv gene, div-1, encodes the B subunit of the DNA polymerase alpha-primase complex.

209 1 protein has also been shown to bind to the DNA polymerase alpha-primase complex.

210 activities of DNA polymerase epsilon and the DNA polymerase alpha-primase complex.

211 Phosphopeptide maps of the p68 subunit of DNA polymerase alpha-primase from human cells, synchroni

212 nuclease activity that copurified with yeast DNA polymerase alpha-primase in a multiprotein complex.

213 lts suggest that the replication activity of DNA polymerase alpha-primase in human cells is regulated

214 DNA polymerase alpha-primase is known to be phosphorylat

215 Consistent with this, the ability of DNA polymerase alpha-primase isolated from synchronized

216 First, DNA polymerase alpha-primase synthesizes the primed site

217 ding to the viral E2 protein and to cellular DNA polymerase alpha-primase were all unaffected in the

218 erase(6), for the G-strand, and subsequently DNA polymerase alpha-primase(7,8) (PolalphaPrim), for th

219 Host enzymes, notably DNA polymerase alpha-primase, DNA ligase I, and topoisom

220 for dimerization and for binding to DNA and DNA polymerase alpha-primase, provides an effective mean

221 on initiation following the requirements for DNA polymerase alpha-primase, replication factor C, and

222 to the BPV1 origin of replication, including DNA polymerase alpha-primase, replication protein A (RPA

223 ty but retained the ability to interact with DNA polymerase alpha-primase, suggesting that the mutant

224 POLA1 encodes the p180 catalytic subunit of DNA polymerase alpha-primase.

225 interacted physically and functionally with DNA polymerase alpha-primase.

226 the six Mcm proteins and the p180 subunit of DNA polymerase alpha-primase.

227 d DNA synthesis, we found no requirement for DNA polymerase alpha-primase.

228 dependent on PRIM1, the primase component of DNA polymerase alpha-primase.

229 terminal 323 residues of the p180 subunit of DNA polymerase alpha-primase.

230 The mammalian DNA polymerase-alpha-primase (Polalpha-primase) complex

231 DNA polymerase-alpha-primase may be isolated from pea sh

232 en, a marker for replication foci containing DNA polymerase-alpha.primase and RPA.

233 sory factor (AAF) stimulates the activity of DNA polymerase-alpha.primase, the only enzyme known to i

234 lex DNA, inhibits DNA synthesis catalyzed by DNA polymerase alpha/primase (pol alpha).

235 re we report that p12(DOC-1) associates with DNA polymerase alpha/primase (pol-alpha:primase) in vitr

236 lular proteins, replication protein A (RPA), DNA polymerase alpha/primase (pol/prim) and topoisomeras

237 ke murine DOC-1, human DOC-1 associates with DNA polymerase alpha/primase and mediates the phosphoryl

238 n part due an ability of p12 to bind to both DNA polymerase alpha/primase and to cyclin-dependent kin

239 d enzyme is needed to keep telomeres intact: DNA polymerase alpha/Primase bound to Ctc1-Stn1-Ten1 (CS

240 complex was found to copurify with the yeast DNA polymerase alpha/primase complex, further supporting

241 proteins, including the Mcm2-7 helicase and DNA polymerase alpha/primase complexes.

242 Purified DNA polymerase alpha/primase was capable of catalyzing s

243 acent short region of DNA are synthesized by DNA polymerase alpha/primase.

244 trast, the distribution of XMCM3, XORC2, and DNA polymerase alpha, proteins required for the initiati

245 d rolling circles, including SV40 T antigen, DNA polymerase alpha, replication protein A (RPA) and RF

246 ells along with E2F1 and the target promoter DNA polymerase alpha, repression of transcription was ob

247 xtends the available data base of eukaryotic DNA polymerase alpha sequences, and suggests new amino a

248 PS AS ODNs against DNA polymerase alpha showed less activity than that for

249 DNA polymerase alpha showed the most discontinuous DNA s

250 rature-sensitive allele of the gene encoding DNA polymerase alpha subunit 2 (pola2) that disrupts fin

251 netically with POL1 and CTF4, which encode a DNA Polymerase alpha subunit and an associated protein,

252 e ability of RPA to increase processivity of DNA polymerase alpha, suggesting that this activity of R

253 However, only PrimPol, DNA polymerase alpha, telomerase, and the mitochondrial

254 FACT histone chaperone in Swi1/TIMELESS and DNA polymerase alpha that are required for heterochromat

255 Mutations in Rif2 and DNA polymerase alpha that cause increased telomere elong

256 Here, we show that the RPC associates with DNA polymerase alpha that primes each Okazaki fragment d

257 subunit (60 kD) of DNA primase, the part of DNA polymerase alpha that synthesizes RNA primers during

258 A primase synthesizes short RNA primers that DNA polymerase alpha then elongates during the initiatio

259 proliferating cell nuclear antigen, but not DNA polymerase alpha, to the nascent replication fork.

260 gistic activation of the p68 subunit gene of DNA polymerase alpha together with E2F3, again dependent

261 facilitates the interaction between Mcm2 and DNA polymerase alpha, two histone-binding proteins criti

262 Decreased DNA polymerase alpha was followed by checkpoint arrest d

263 st, bypass replication efficiency with yeast DNA polymerase alpha was no more than 1 percent.

264 However, no repression of DNA polymerase alpha was seen if the cells expressed a n

265 Discontinuous DNA synthesis by DNA polymerase alpha was seen with substrates containing

266 e kinase activity, no significant changes in DNA polymerase alpha were observed in factor-deprived NF

267 Two other TATA-less promoters, cyclin D3 and DNA polymerase alpha, were also found to be repressed by

268 vity, as well as an association of PARP with DNA polymerase alpha, within 12-24 h of exposure to indu