ライフサイエンスコーパス: DNA polymerase eta

1 Saccharomyces cerevisiae RAD30 gene encodes DNA polymerase eta.

2 olymerase to be described and hence is named DNA polymerase eta.

3 te DNA misincorporation process catalyzed by DNA polymerase eta.

4 he nucleotide excision repair pathway and in DNA polymerase eta.

5 t also targets other factors such as E2F and DNA polymerase eta.

6 re overwhelmingly achieved by recruitment of DNA polymerase eta.

7 /MM simulations on a specific Pol, the human DNA polymerase-eta, an enzyme involved in repairing dama

8 tively, which leads to the insertion of A by DNA polymerase eta and defines a probable mechanism for

9 us reports described the bypass of M(1)dG by DNA polymerases eta and Dpo4.

10 Human DNA polymerases eta and iota are best characterized for

11 cesses that include translesion synthesis by DNA polymerases eta and zeta and a Rad5-Mms2-Ubc13-contr

12 replication by DNA polymerase zeta/Rev1 and DNA polymerase eta, and the error-free, recombination-de

13 Human DNA polymerase eta bypass may lead to M(1)dG to dT and f

14 The sequences of full-length human DNA polymerase eta bypass products of M(1)dG were determ

15 Yeast DNA polymerase eta can replicate through cis-syn cyclobu

16 DNA polymerase eta carries out translesion synthesis pas

17 ng activation-induced cytidine deaminase and DNA polymerase-eta, contribute to the molecular lesions

18 of A nucleotides, which are incorporated by DNA polymerase eta, decreased 10-fold before the repetit

19 ntaneous carcinogenesis model in the skin of DNA polymerase eta-deficient mice and found that interst

20 cture of the catalytic core of S. cerevisiae DNA polymerase eta, determined at 2.25A resolution.

21 Native human DNA polymerase eta, DNA and dATP were co-crystallized at

22 ve roles in vivo of Saccharomyces cerevisiae DNA polymerase eta, DNA polymerase zeta, Rev1 protein, a

23 auses RNA polymerase II and limits access of DNA polymerase eta during hypermutation.

24 a partial requirement for the lesion bypass DNA polymerase eta encoded by the human POLH gene.

25 tch occurs to allow translesion synthesis by DNA polymerase eta, followed by another switch that allo

26 Human DNA polymerase eta functions similarly in the bypass of

27 ynthesis (TLS) of this lesion, while loss of DNA polymerase eta has no detectable effect.

28 two non-classical DNA polymerases, Rev1 and DNA polymerase eta, have two architectures: PCNA tool be

29 e investigated the interaction between human DNA polymerase eta (hpol eta) and the Werner syndrome pr

30 Recombinant human DNA polymerase eta (hpol eta) can replicate oligonucleot

31 Human DNA polymerase eta (hPol eta) contributes to anticancer

32 ighly conserved amino acid, within the human DNA polymerase eta (hPol eta) finger domain.

33 ke the other Y-family DNA polymerases, human DNA polymerase eta (hpol eta) has relatively low fidelit

34 Y-family human DNA polymerase eta (hpol eta) is of interest because of

35 Human DNA polymerase eta (hPol eta) is one of the newly identi

36 anslesion synthesis (TLS), mediated by human DNA polymerase eta (hpol eta), and on RNase H2-mediated

37 o analyze in vitro bypass of 8-oxoG by human DNA polymerase eta (hpol eta).

38 Human DNA polymerase eta (hPoleta) functions in the error-free

39 ypass products synthesized by human Y-family DNA polymerases eta (hPoleta), iota (hPoliota) and kappa

40 and Rad3-related (ATR) kinase or translesion DNA polymerase eta (i.e. key proteins that promote the c

41 DNA polymerase eta is not protective for deletions at AT

42 DNA polymerase eta is the most efficient polymerase for

43 DNA polymerase eta is unique among eukaryotic polymerase

44 proposed to arise from the insertion of A by DNA polymerase eta opposite the T that results from deam

45 pass involves translesion synthesis (TLS) by DNA polymerases eta or zeta or Rad5-dependent postreplic

46 Knocking-down expression of DNA polymerase eta, or using PCNA ubiquitination-resista

47 To determine whether DNA polymerase eta plays a role in the hypermutation of

48 ent time-resolved crystallography studies on DNA polymerase eta (Pol eta) and beta have revealed esse

49 Although DNA polymerase eta (Pol eta) and other Y family polymera

50 Recruitment of DNA polymerase eta (Pol eta) and other Y-family TLS poly

51 and time-resolved X-ray crystallography with DNA polymerase eta (Pol eta) as a model system, we showe

52 DNA polymerase eta (Pol eta) bypasses a cis-syn thymine-

53 DNA polymerase eta (Pol eta) catalyzes accurate bypass o

54 Mutation of the POLH gene encoding DNA polymerase eta (pol eta) causes the UV-sensitivity s

55 s that inaccurate DNA synthesis by mammalian DNA polymerase eta (pol eta) contributes to somatic hype

56 When human DNA polymerase eta (pol eta) encounters N6-deoxyadenosin

57 A deficiency in mouse DNA polymerase eta (pol eta) enhanced UV-induced Hprt mu

58 DNA polymerase eta (Pol eta) functions in the error-free

59 DNA polymerase eta (Pol eta) functions in the proficient

60 variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to

61 Our data indicates that yeast DNA polymerase eta (pol eta) has varied impact on UV-ind

62 Here, we report an elevated expression of DNA polymerase eta (Pol eta) in ovarian CSCs isolated fr

63 DNA polymerase eta (Pol eta) is a member of a new class

64 DNA polymerase eta (pol eta) is best known for its abili

65 Human DNA polymerase eta (Pol eta) is best known for its role

66 Human DNA polymerase eta (Pol eta) modulates susceptibility to

67 Human DNA polymerase eta (Pol eta) plays an essential protecti

68 o explain how translesion synthesis (TLS) by DNA polymerase eta (pol eta) suppresses ultraviolet ligh

69 the efficient recruitment of the specialized DNA polymerase eta (pol eta) to replication-associated f

70 e other hand, yeast Saccharomyces cerevisiae DNA polymerase eta (pol eta) was able to replicate past

71 s showed that yeast Saccharomyces cerevisiae DNA polymerase eta (pol eta) was able to replicate past

72 ribe here the error specificity of mammalian DNA polymerase eta (pol eta), an enzyme that performs tr

73 DNA polymerase eta (pol eta), encoded by the xeroderma p

74 Here, we report that DNA polymerase eta (Pol eta), known to possess RT activi

75 OLH gene encoding an error-prone polymerase, DNA polymerase eta (pol eta).

76 ein to stimulate nucleotide incorporation by DNA polymerase eta (pol eta).

77 ine dimer, and most undamaged bases by yeast DNA polymerase eta (pol eta).

78 lfataricus DNA polymerase 4 (Dpo4) and human DNA polymerase eta (Pol eta).

79 Human DNA polymerase eta (Pol(eta)), encoded by the Xeroderma

80 DNA polymerase eta (Pol(eta), xeroderma pigmentosum vari

81 umors positively correlated with mutation of DNA polymerase eta (POLE) and TP53 as well as high expre

82 hat DNA repair synthesis, catalyzed by human DNA polymerase eta (poleta) acting upon the priming stra

83 Recent studies suggest that DNA polymerase eta (poleta) and DNA polymerase iota (pol

84 DNA polymerase eta (poleta) belongs to the Y-family of D

85 s accumulate in the absence of RAD30-encoded DNA polymerase eta (Poleta) but not in the absence of RE

86 The yeast RAD30-encoded DNA polymerase eta (Poleta) bypasses a cis-syn thymine-t

87 DNA polymerase eta (Poleta) catalyzes the efficient and

88 DNA polymerase eta (Poleta) functions in error-free bypa

89 DNA polymerase eta (Poleta) functions in error-free repl

90 DNA polymerase eta (Poleta) has the unique ability to re

91 DNA polymerase eta (Poleta) has unique and pivotal funct

92 Pre-steady-state kinetic studies on Y-family DNA polymerase eta (Poleta) have suggested that the poly

93 ow evolution might have biochemically shaped DNA polymerase eta (Poleta) in plants, we expressed in E

94 dence for the involvement of yeast and human DNA polymerase eta (Poleta) in the replicative bypass of

95 We have examined the role of DNA polymerase eta (Poleta) in translesion synthesis of

96 DNA polymerase eta (Poleta) is a low-fidelity enzyme abl

97 DNA polymerase eta (Poleta) is a unique translesion DNA

98 DNA polymerase eta (Poleta) is unique among eukaryotic D

99 DNA polymerase eta (Poleta) is unique among eukaryotic p

100 Notably, cells depleted of DNA polymerase eta (Poleta) or the E3 ubiquitin ligase R

101 Interestingly, human DNA polymerase eta (poleta) proficiently incorporates dG

102 on-induced deoxycytidine deaminase (AID) and DNA polymerase eta (Poleta) to diversify immunoglobulin

103 The E3 ubiquitin ligase Rad18 guides DNA Polymerase eta (Poleta) to sites of replication fork

104 The E3 ubiquitin ligase Rad18 chaperones DNA polymerase eta (Poleta) to sites of UV-induced DNA d

105 gmentosum (XPV) is caused by a deficiency in DNA polymerase eta (Poleta), a DNA polymerase that enabl

106 e, we show that Rad18 is targeted to PCNA by DNA polymerase eta (Poleta), the XPV gene product that i

107 translesion synthesis (TLS) DNA polymerases, DNA polymerase eta (poleta), was upregulated within 72 h

108 Here, leveraging recent structural data on DNA polymerase eta (Poleta), we elucidate its translocat

109 Eukaryotic cells possess DNA polymerase eta (Poleta), which has the ability to re

110 With the exception of DNA polymerase eta (poleta), which is defective in human

111 ed bases in vitro but, with the exception of DNA polymerase eta (poleta), which is defective in xerod

112 acetylation of Poliota's closest paralogue, DNA polymerase eta (Poleta), with which Poliota shares m

113 free translesion synthesis (TLS) mediated by DNA polymerase eta (Poleta).

114 S via interaction with the catalytic core of DNA polymerase-eta (poleta), and that NPM1 deficiency ca

115 DNA polymerase eta (PolH) is the product of the xeroderm

116 DNA polymerase eta (PolH), a Y family translesion polyme

117 DNA polymerase eta (PolH, Poleta) belongs to the Y-famil

118 DNA polymerase eta (Poln) is a unique translesion DNA sy

119 ytidine deaminase (AID) and the A-T mutator, DNA polymerase eta, respectively, in mutagenesis in norm

120 in vitro activities of mammalian translesion DNA polymerase eta: tandem base substitutions, strand sl

121 Human DNA polymerase eta, the product of the skin cancer susce

122 es two key enzymes in translesion synthesis: DNA polymerase eta, the yeast Xeroderma pigmentosum orth

123 e site is the critical feature which enables DNA polymerase eta to replicate through DNA lesions such

124 The ability of recombinant human DNA polymerase eta to synthesize DNA across from M(1)dG

125 Here we use extensive simulations of DNA polymerase eta to test mechanistic hypotheses.

126 , indicating that DNA repair and error-prone DNA polymerase eta usage were unaffected.

127 way (groups A-G) or in Translesion Synthesis DNA polymerase eta (V).

128 DNA polymerase eta was found to be involved only rarely

129 Human DNA polymerase eta was used to copy four stereoisomeric

130 Extracts from HeLa cells, which express DNA polymerase eta, were competent to replicate past the

131 bypass of a cyclobutane pyrimidine dimer by DNA polymerase eta (XP-V or Rad30) or bypass of a (6-4)

132 hanism of translesion synthesis by the yeast DNA polymerase eta (yPoleta), a gel retardation techniqu

133 We have used yeast DNA polymerases eta, zeta and Rev1 to study translesion