ライフサイエンスコーパス: DNA polymerase gamma

1 o associated with the mitochondrion-specific DNA polymerase gamma.

2 ass of template base dFdC catalyzed by human DNA polymerase gamma.

3 chondrial DNA replication catalyzed by human DNA polymerase gamma.

4 to reduce the replication fidelity of human DNA polymerase gamma.

5 talytic subunit of replicative mitochondrial DNA polymerase gamma.

6 ulate the 140 kDa catalytic subunit of human DNA polymerase gamma.

7 ance and high processivity characteristic of DNA polymerase gamma.

8 (RT), adenylate/guanylate kinase, and human DNA polymerase gamma.

9 o site-directed mutant proteins of the human DNA polymerase gamma.

10 s a selective inhibitor of the mitochondrial DNA polymerase gamma.

11 ock the action of the 3'-->5' exonuclease of DNA polymerase gamma.

12 rate for subsequent gap-filling synthesis by DNA polymerase gamma.

13 DNA polymerases including the mitochondrial DNA polymerase gamma.

14 ediated indirectly through the inhibition of DNA polymerase-gamma.

15 glycosylase, oxoguanine DNA glycosylase and DNA polymerase gamma activities all co-sedimented with t

16 Deficiency of mitochondrial DNA polymerase gamma activity was found in a patient wit

17 p53+/+ mitochondrial extracts had higher DNA polymerase-gamma activity measured by (32)P-dCTP inc

18 53 complemented p53-/- mitochondrial extract DNA polymerase-gamma activity.

19 incorporated in vitro by HIV-1 RT and human DNA polymerase gamma and did enable specific HIV-1 DNA l

20 ial characterization of the large subunit of DNA polymerase gamma and establishes the baseline for ex

21 1-mer primer-template reduced the binding of DNA polymerase gamma and the efficiency of primer extens

22 e mitochondria, interacts with mitochondrial DNA polymerase gamma, and significantly stimulates polym

23 ndrial lysates permitted isolation of native DNA polymerase gamma as a single subunit, allowing direc

24 These patterns implicate replication by DNA polymerase gamma as the deletion driver and suggest

25 Observation of native DNA polymerase gamma both as an Hp140 monomer and as a h

26 Mitochondrial DNA (mtDNA) is replicated by DNA polymerase gamma by a strand displacement mechanism

27 Inducible expression of a dominant negative DNA polymerase-gamma can yield mtDNA-deficient cell line

28 The human DNA polymerase gamma catalytic subunit was overexpressed

29 CSB-dependent depletion of the mitochondrial DNA polymerase-gamma catalytic subunit (POLG1), due to H

30 ed expression of a dominant negative form of DNA polymerase gamma causes a metabolic shift from oxida

31 arameters indicate that the large subunit of DNA polymerase gamma could replicate the mitochondrial g

32 study, we show that the human mitochondrial DNA polymerase gamma discriminates ribonucleotides effic

33 The nuclear-encoded DNA polymerase gamma (DNA POL gamma) is the sole DNA pol

34 plication was mediated through inhibition of DNA polymerase-gamma (DNA pol-gamma), by FIAU triphospha

35 The consensus sequences for the DNA polymerase gamma exonuclease and polymerase domains

36 hat is not found in the other members of the DNA polymerase gamma family, or in other family A DNA po

37 tagenesis of mtDNA by proofreading-deficient DNA-polymerase gamma followed by segregation of the resu

38 Comparison of the four DNA polymerase gamma gene sequences revealed several hig

39 transfected with a plasmid encoding inactive DNA polymerase-gamma harboring a D1135A substitution (PO

40 ed purified mtDNA replication proteins, i.e. DNA polymerase gamma holoenzyme, the mitochondrial singl

41 MGME1 with the 3'-5' exonuclease activity of DNA polymerase gamma in mtDNA degradation.

42 ers present an obstacle to the mitochondrial DNA polymerase gamma in subsequent rounds of replication

43 e of their potential for inhibition of human DNA polymerase gamma involved in mitochondrial DNA repli

44 DNA polymerase gamma is a core component of the mtDNA re

45 DNA polymerase gamma is also proficient in performing si

46 The S.cerevisiae DNA polymerase gamma is atypical in that it includes a 2

47 Human DNA polymerase gamma is composed of a 140-kDa catalytic

48 Human DNA polymerase gamma is composed of a 140-kDa catalytic

49 DNA polymerase gamma is responsible for replication and

50 ion suggests that the large subunit of human DNA polymerase gamma may require accessory factors to in

51 progeroid phenotype of exonuclease-deficient DNA polymerase gamma mice has been intensely debated.

52 rofiles of wild-type and Polg (mitochondrial DNA polymerase gamma) mutant mice, we found that mice wi

53 hen dFdC was encountered as a template base, DNA polymerase gamma paused at the lesion and one downst

54 DNA polymerase gamma (pol gamma ) is required to maintai

55 (APE1), is removed by the lyase activity of DNA polymerase gamma (pol gamma) and polymerase beta in

56 ) is believed to coordinate the functions of DNA polymerase gamma (pol gamma) and the mitochondrial D

57 Xenopus laevis DNA polymerase gamma (pol gamma) exhibits low activity o

58 mpeded the processivity of the mitochondrial DNA polymerase gamma (Pol gamma) in vitro, providing a p

59 Mitochondrial DNA polymerase gamma (pol gamma) is active in base excis

60 The replication accuracy of DNA polymerase gamma (Pol gamma) is essential for mitoch

61 e to its association with mitochondrial DNA, DNA polymerase gamma (pol gamma) is in an environment to

62 DNA polymerase gamma (pol gamma) is required for replica

63 The human DNA polymerase gamma (Pol gamma) is responsible for DNA

64 DNA polymerase gamma (pol gamma) is responsible for repl

65 Mitochondrial DNA polymerase gamma (pol gamma) is responsible for repl

66 Human mitochondrial DNA polymerase gamma (pol gamma) is solely responsible f

67 The activity of the mitochondrial replicase, DNA polymerase gamma (Pol gamma) is stimulated by anothe

68 Human DNA polymerase gamma (pol gamma) requires association of

69 ochondrial DNA is replicated and repaired by DNA polymerase gamma (pol gamma), encoded by the POLG ge

70 onstrated that the mitochondrial polymerase, DNA polymerase gamma (pol gamma), participates in mitoch

71 mitochondrial DNA depends on the accuracy of DNA polymerase gamma (pol gamma), we investigated the fi

72 Ed4T with wild-type (WT) human mitochondrial DNA polymerase gamma (pol gamma), which is often associa

73 oding the sole mitochondrial DNA polymerase, DNA polymerase gamma (pol gamma).

74 have shown that the small subunit of Xenopus DNA polymerase gamma (pol gammaB) acts as a processivity

75 ocated on nuclear chromosome 15, encodes the DNA polymerase gamma(Pol gamma).

76 ) maintenance, we confirmed mutations in the DNA polymerase gamma POLG in positive control cases, and

77 Here we show that a proofreading mutant of DNA polymerase gamma (PolG(D256A)) increases the mtDNA m

78 characterized by deficiency in mitochondrial DNA polymerase gamma (POLG) catalytic activity, refracto

79 rtion site is the 3' noncoding region of the DNA polymerase gamma (PolG) gene on chromosome 7.

80 DNA polymerase gamma (POLG) is essential for replication

81 gous for the D257A mutation in mitochondrial DNA polymerase gamma (Polg) or with mice having both mut

82 the gene for the catalytic subunit of human DNA polymerase gamma, POLG, the A467T substitution is th

83 ing proteins identified the alpha-subunit of DNA polymerase gamma (Polga) as a client protein.

84 The DNA polymerase gamma (Polgamma) repairs and replicates t

85 n mitochondrial DNA (mtDNA) is replicated by DNA polymerase gamma (POLgamma), a heterotrimeric comple

86 s in POLG, which codes for the mitochondrial DNA polymerase gamma (polgamma), cause Alpers-Huttenloch

87 DNA polymerase gamma (POLgamma), responsible for mitocho

88 cision repair (BER) enzymes, namely EXOG and DNA polymerase gamma (Polgamma), which under oxidative s

89 has weak DNA unwinding activity, and assists DNA polymerase gamma (Polgamma)-catalyzed strand-displac

90 is of off-target inhibition of mitochondrial DNA polymerase gamma (Polgamma).

91 al for cellular energy production, relies on DNA polymerase gamma (POLgamma).

92 structures representing human mitochondrial DNA polymerase Gamma, Polgamma, captured during consecut

93 that expression of the catalytic subunit of DNA polymerase gamma (POLgammaCAT) mRNA varies little am

94 The accessory subunit of mitochondrial DNA polymerase gamma, POLGbeta, functions as a processiv

95 These results demonstrate that the DNA polymerase gamma protein is stable in the absence of

96 t peptide sequences were shown to react with DNA polymerase gamma purified from X.laevis oocyte mitoc

97 In higher eukaryotes, mitochondrial DNA polymerase gamma relies on the replicative helicase

98 Replication of the mitochondrial genome by DNA polymerase gamma requires dNTP precursors that are s

99 , the gene encoding the catalytic subunit of DNA polymerase gamma, result in clinical syndromes chara

100 ase and polymerase active sites is larger in DNA polymerase gamma than in other members of family A (

101 Mitochondrial DNA polymerase (DNA polymerase gamma), the nuclear-encoded enzyme which

102 d a cDNA encoding the large subunit of human DNA polymerase gamma, the enzyme that replicates the mit

103 own sequence of the Saccharomyces cerevisiae DNA polymerase gamma to clone the genes or cDNAs encodin

104 inant negative form of mitochondria-specific DNA polymerase-gamma to eliminate mitochondrial DNA (mtD