ライフサイエンスコーパス: DNA repair

1 e of defective homologous recombination (HR) DNA repair.

2 that is distinct from its known function in DNA repair.

3 asis, affects ATP production, and attenuates DNA repair.

4 eased longevity by regulating metabolism and DNA repair.

5 n also serve as DNA damage codes to regulate DNA repair.

6 tiple roles in transcription, signaling, and DNA repair.

7 -Ligase3 and other repair factors to promote DNA repair.

8 al cancer that regulates PI3K activation and DNA repair.

9 h genes regarding two processes: meiosis and DNA repair.

10 ermal growth factor receptor (EGFR)-mediated DNA repair.

11 netic marks that are necessary for efficient DNA repair.

12 ation of substrate maximizes the fidelity of DNA repair.

13 sis, metabolic reprogramming, metastasis and DNA repair.

14 cell cycle arrest that normally accompanies DNA repair.

15 ter chromatid cohesion, gene expression, and DNA repair.

16 esses homologous recombination (HR)-mediated DNA repair.

17 complex with key roles in various aspects of DNA repair.

18 ular mechanisms of RecBCD-Chi regulation and DNA repair.

19 s during transcription, DNA replication, and DNA repair.

20 dification associated with transcription and DNA repair.

21 ttenuated XRCC1-LIG3 recruitment and delayed DNA repair.

22 can be separated from its known functions in DNA repair.

23 essential for progression and completion of DNA repair.

24 tead of the RAD50 hook properly functions in DNA repair.

25 eractions between cholesterol biogenesis and DNA repair.

26 DNA sequences to enable accurate and timely DNA repair.

27 nd patient-derived neurospheres by impairing DNA repair.

28 ISPR spacer acquisition to constructive host DNA repair.

29 of SIRT6 in maintaining genome integrity and DNA repair.

30 itive GBM models from radiation by promoting DNA repair.

31 NA polymerase beta (Pol beta) to function in DNA repair.

32 2F2 transcriptionally regulates mediators of DNA repair.

33 evidence for a specialized role for HMCES in DNA repair.

34 (ADP-ribose) polymerases (PARPs) to initiate DNA repair.

35 eatments that stimulate PAR synthesis during DNA repair.

36 CHK2) controls histone degradation to assist DNA repair.

37 tion, activating antioxidants, and enhancing DNA repair.

38 iency of DNA replication, transcription, and DNA repair.

39 ivergent requirements for Ino80-dependent HR DNA repair.

40 eractions with the microbiota, and defective DNA repair.

41 e pathway by which these metabolites disrupt DNA repair.

42 d by special cellular machinery that induces DNA repair.

43 ucture, gene expression, RNA processing, and DNA repair.

44 s to DNA damage sites is a critical step for DNA repair.

45 omatid cohesion, chromosome segregation, and DNA repair.

46 ISPR array acquisition (adaptation) and host DNA repair.

47 ic regulation of exonuclease 1 (Exo1) during DNA repair.

48 uclear processes including transcription and DNA repair.

49 omeres protect chromosome ends from aberrant DNA repair(1).

50 ring gene transcription, DNA replication and DNA repair(2).

51 Despite its role in DNA repair, AAG-initiated BER promotes cytotoxicity in a

52 release of the donor template and subsequent DNA repair activated expression of the selectable marker

53 gle cells to understand the heterogeneity of DNA repair activities across thousands of human lymphocy

54 ation (SHM) targeting, including error-prone DNA repair activities that are crucial to Ab diversifica

55 gested that ATM inhibition does not increase DNA repair after cisplatin-induced DNA damage and exacer

56 gether with DNA damage and downregulation of DNA repair and antioxidant enzymes.

57 deficient for homologous recombination (HR) DNA repair and are sensitive to DNA-damaging agents such

58 expression of > 40 gene products involved in DNA repair and cell cycle regulation.

59 s are part of mitosis and play vital role in DNA repair and cell-cycle regulation.

60 nase that has a central role in coordinating DNA repair and cell-cycle response following DNA damage,

61 or tissue types; however, groupings of other DNA repair and DDR genes are correlated with APE2 with d

62 also examine the mRNA expression of 13 other DNA repair and DDR genes from matched samples for 6 canc

63 se studies demonstrate that EGF promotes HSC DNA repair and hematopoietic regeneration in vivo via au

64 Tregs showed upregulation of genes promoting DNA repair and immune cell trafficking, in addition to d

65 n of CDK6 but not CDK4 resulted in defective DNA repair and increased DNA damage.

66 n genes that are involved in viral immunity, DNA repair and metabolism.

67 imulation of A3B expression by activation of DNA repair and NF-kappaB pathways could promote cancer m

68 while structurally unrelated, play roles in DNA repair and other aspects of DNA metabolism in human

69 f DNA repair; however, little is known about DNA repair and other E2F family members.

70 f epidermal growth factor (EGF) promoted HSC DNA repair and rapid hematologic recovery in chemotherap

71 erations in mechanistic target of rapamycin, DNA repair and receptor tyrosine kinase pathways.

72 different cellular events in recombinational DNA repair and replication fork stabilization.

73 tion of TOP II and Ku70, crucial enzymes for DNA repair and replication, as well as MiR-155 oncogene,

74 autophagy and regulation of macroautophagy, DNA repair and replication, as well as organization of m

75 und that overexpression of LRRC31 suppresses DNA repair and sensitizes BCBMs to radiation.

76 K(1268) ubiquitylation affects DNA repair and signals RNAPII degradation, essential for

77 ic insight into the new function of GAPDH in DNA repair and suggest a potential therapeutic target in

78 gue anti-cancer therapies and is linked with DNA repair and suppression of the interferon response to

79 utic strategies, including the modulation of DNA repair and targeting the DNA mutation itself.

80 hondrial genes in oxidative phosphorylation, DNA repair and the cell cycle, and shows their connectio

81 Defects in DNA repair and the protection of stalled DNA replication

82 e 1 (PARP-1) is a nuclear enzyme involved in DNA repair and transcription regulation, among other pro

83 This drives the overexpression of DNA repair and tumour suppressor genes, rendering these

84 Immune response, DNA repair, and apoptosis displayed greater mediation th

85 s like RNA editing, translation, metabolism, DNA repair, and biological conflicts, and some unexpecte

86 gradation process involved in transcription, DNA repair, and cell division.

87 ays in which DNA replication, transcription, DNA repair, and chromatin state interact and thereby pro

88 ts regulated gene expression, recombination, DNA repair, and chromosome segregation during mitosis.

89 g DNA access for transcription, replication, DNA repair, and epigenetic modification, chromatin forms

90 logical development, protein degradation and DNA repair, and is unaffected by the presence of melanin

91 e find increased constraint in inflammation, DNA repair, and NFKB-related pathways.

92 inase signaling, cytoskeleton, RNA splicing, DNA repair, and nuclear lamina.

93 eflecting defective homologous recombination DNA repair, and positive immune score as a surrogate of

94 ted processes, including gene transcription, DNA repair, and replication.

95 tions, including transcriptional repression, DNA repair, and telomere maintenance.

96 e that plays a role in chromatin remodeling, DNA repair, and transcriptional regulation.

97 These data implicate DNA repair as a key quality control mechanism in the fem

98 ol beta) plays an important role in cellular DNA repair, as it fills short gaps in dsDNA that result

99 Chromatin is a barrier to efficient DNA repair, as it hinders access and processing of certa

100 RNIP1), RAD51 recombinase (RAD51), and BRCA2 DNA repair associated (BRCA2) to stalled forks and that

101 Virtually all MM subgroups have activated DNA repair-associated signature as a prominent late muta

102 r p53-mediated biological processes, such as DNA repair, autophagy, and energy metabolism.

103 e-marrow-derived progenitors actively engage DNA repair but also imprint a formaldehyde-driven mutati

104 ental requirement for cell proliferation and DNA repair, but no single method can identify the locati

105 ggested to have extraglycolytic functions in DNA repair, but the underlying mechanism for the GAPDH r

106 and in an allele-specific manner, leading to DNA repair by gene conversion or NHEJ.

107 Restoring DNA repair by nuclear over-expression of phosphomimetic

108 ted connection between these metabolites and DNA repair by showing that they suppress the pathway of

109 r microenvironments, thereby enhancing tumor DNA repair capacity and chemotherapy resistance.

110 NAD(+) levels also affect DNA repair capacity as NAD(+) is a substrate for PARP-en

111 micals for genotoxicity, and knowledge about DNA repair capacity has applications in precision preven

112 ing inducing genome instability and changing DNA repair capacity in prostate cancer cells.

113 osis, ERK activity, cell-cycle duration, and DNA repair capacity in the absence or presence of a drug

114 cellular NAD(+) content and NAD(+)-dependent DNA repair capacity.

115 volved in the DNA damage response, impacting DNA repair, cell cycle arrest and apoptosis.

116 y, we find that genes related to cell cycle, DNA repair, cell death, the IGF1 pathway, and immunity a

117 h is involved in regulating gene expression, DNA repair, chromatin remodeling, apoptosis, and cell pr

118 lar functions, including metabolic pathways, DNA repair, chromatin remodelling, cellular senescence a

119 ant dysregulation of transcripts involved in DNA repair, chromocenter formation, and tumorigenesis in

120 tumors, as well as the effects of defective DNA repair, chromosome instability, microsatellite insta

121 delineate functional regions in an important DNA repair complex and suggest possible molecular diseas

122 A and UVSSA and the manner in which the core DNA repair complex, including transcription factor IIH (

123 filtrating macrophages carrying an ERCC1-XPF DNA repair defect (Er1(F/-)) triggers Golgi dispersal, d

124 rkedly delays their resolution, indicating a DNA repair defect.

125 of TWT melanomas and revealed enrichment of DNA-repair-defect signatures in this subtype, which were

126 analyse 2,717 genomes from wild-type and 53 DNA repair defective backgrounds, exposed to 11 genotoxi

127 eatures identified subgroups associated with DNA repair defects and poor prognosis.

128 DNA repair defects are found in primary and metastatic p

129 sequencing to reveal that genetic rescue of DNA repair-deficient germ cells (Fancm(-/-) ) leads to i

130 ficacy against homologous recombination (HR) DNA repair-deficient HGSOC-patient-derived xenograft (PD

131 ogy in mice with important ramifications for DNA repair-deficient, progeroid syndromes and aging.

132 ional repression, chromatin modification, or DNA repair, delineating a pathway relationship with MECP

133 ay, cellular and genetic context nominates a DNA repair dependency in KRAS-mutant cells, mediated by

134 While mechanisms of DNA repair during meiotic recombination are well charact

135 seq are (i) low false-positive rates because DNA repair enzyme binding is required for genome edits t

136 Higher expression of the human DNA repair enzyme MUTYH has previously been shown to be

137 Because BLBC exhibits alterations in DNA repair enzymes and cell-cycle checkpoints, elucidati

138 irpin-helix DNA-binding motif found in other DNA repair enzymes.

139 e presents one of the greatest challenges to DNA repair enzymes.

140 y the tumor mutational burden and defects in DNA repair enzymes.

141 anics of M/R chromosomal manipulation during DNA-repair events remain unclear.

142 ld containing protein that binds ssDNA, as a DNA repair factor involved in HR.

143 Furthermore, DNA repair factors involved in homologous recombination

144 It leverages the recruitment of DNA repair factors to double-strand breaks (DSBs) after

145 (RNAP), leading to subsequent recruitment of DNA repair factors to the stalled transcription complex.

146 found that CSA and CSB, primarily defined as DNA repair factors, are located at the midbody, a transi

147 The induced APBs lack DNA repair factors, indicating that APB functions in pro

148 e clustering can be uncoupled from enriching DNA repair factors.

149 h distinct interfaces that may recruit other DNA repair factors.

150 erve as DNA damage codes to recruit specific DNA repair factors.

151 ak (DSB) repair pathways in human cells, how DNA repair failures can lead to human disease, and how P

152 he cell nucleus, suggesting implications for DNA repair fidelity and subsequent cell fate.

153 ell understood, and therapies to augment HSC DNA repair following myelosuppression remain undeveloped

154 ased cell-cycle progression delay and slowed DNA repair following radiation, enhancing colony and sph

155 models and tested the impact of ATM loss on DNA repair function and therapeutic sensitivities.

156 essential for its nuclear translocation and DNA repair function.

157 DNA repair GAs are relatively frequent in GBC and associ

158 We investigated the frequency of DNA repair GAs in gallbladder cancer (GBC), association

159 Both direct and caretaker DNA repair GAs were significantly associated with high T

160 DNA repair gene aberrations (GAs) occur in several cance

161 with carcinogenesis accelerated by germline DNA repair gene defects.

162 ant signals in a chr15 region containing the DNA repair gene Fanconi-Associated Nuclease 1 (FAN1).

163 Direct DNA repair gene GAs were identified in 109 patients (14.

164 n the levels of several tumor suppressor and DNA repair gene protein products (GP)s at the end of 4th

165 etween identical DNA molecules contribute to DNA repair, gene expression, chromosome segregation, and

166 roles of PARP1 in cellular processes such as DNA repair, gene transcription and cell death have allow

167 GAs in 19 DNA repair genes including direct DNA repair genes (ATM, ATR, BRCA1, BRCA2, FANCA, FANCD2,

168 We investigated GAs in 19 DNA repair genes including direct DNA repair genes (ATM,

169 in these tumors is dominated by mutations in DNA repair genes that are further linked to microsatelli

170 ood-brain barrier, telomere homeostasis, and DNA repair genes were significantly associated with cogn

171 ts with TMPRSS2-ERG fusions and mutations in DNA repair genes, PARG inhibitors have not been evaluate

172 d with transcriptional downregulation of key DNA-repair genes, and may revive previously discarded or

173 on of connections that link cellular iron to DNA repair, genomic integrity, and oncogenic signaling a

174 ted and that it is significantly faster than DNA repair glycosylases that recognize and excise some o

175 Mechanistic studies in DNA repair have focused on roles of multi-protein DNA co

176 RPA depletion and impaired homology-directed DNA repair (HDR) activity.

177 has been shown to be a critical mediator of DNA repair; however, little is known about DNA repair an

178 osis, cell cycle, cell death, cell motility, DNA repair, immune response, two phosphorylation pathway

179 rmal growth factor receptor (EGFR) regulates DNA repair in HSCs following irradiation via activation

180 helps maintain homologous recombination (HR) DNA repair in human cells and functions as a tumor suppr

181 RPA stimulates RNA-templated DNA repair in vitro and associates in vivo with R-loops,

182 USP22 in modulation of cellular survival and DNA repair, in part through regulation of XPC.

183 tion, thereby influencing crucial aspects of DNA repair, including donor choice and the possibility o

184 on alterations in genes that are involved in DNA repair, including homologous recombination repair, a

185 double-strand breaks but reduced markers of DNA repair, indicating that autophagy is required for ba

186 We assayed DNA repair indirectly as toxicity and directly measured

187 of the repair process: the landscape of the DNA repair is highly sparse in the (Walsh-Hadamard) spec

188 how long non-coding RNAs (lncRNAs) regulate DNA repair is less well understood.

189 es the concept that homologous recombination DNA repair is not an all-or-nothing concept, but a spect

190 Extrinsic regulation of HSC DNA repair is not well understood, and therapies to augm

191 However, because the function of APE2 in DNA repair is poorly understood, it is unclear why BRCA-

192 n response to mutagen exposure and find that DNA repair is required to mitigate transcriptional mutag

193 an essential nuclease-helicase implicated in DNA repair, lagging-strand DNA synthesis, and the recove

194 PRL and reduces the time to compute the full DNA repair landscape from a striking 5230 years to 1 wee

195 erimental type 1 and type 2 diabetes impairs DNA repair, leading to senescence, inflammatory phenotyp

196 this resistance is mediated by variations in DNA repair levels or net drug influx.

197 their complex crosstalk with the compromised DNA repair machinery of BRCA1/2-mutant cells.

198 e 3' flap for potential interaction with the DNA repair machinery.

199 Since defects in DNA repair may lead to cancer and genetic instabilities,

200 ely, our findings lend insights into a basic DNA repair mechanism and how the precise location of a D

201 BLM helicase gene resulted in defects in the DNA repair mechanism and was reported to be associated w

202 ve stress, impacting gene expression via the DNA repair mechanism that reads and ultimately erases th

203 ide excision repair (TC-NER) is an important DNA repair mechanism that removes RNA polymerase (RNAP)-

204 We propose that elucidation of DNA repair mechanisms elicited by different irradiation

205 s of ionizing radiation despite sharing most DNA repair mechanisms with other eukaryotes.

206 accumulate mutations and lacks conventional DNA repair mechanisms, deleterious mutations are exceedi

207 , including apoptosis, genome stabilization, DNA repair, metabolism, migration, and invasion.

208 ence, protein quality control, mitochondrial DNA repair, mitochondrial dynamics, mitophagy and mitoch

209 y and scaling of current deep-learning-based DNA repair models.

210 t uses a fast peeling algorithm to learn the DNA repair models.

211 ty of cellular functions, including roles in DNA repair, mRNA processing, and regulation of RNA polym

212 having rapid assays to quantify DNA damage, DNA repair, mutations, and cytotoxicity is broadly relev

213 of mitochondrial DNA due to the lack of the DNA repair nuclease MRE11A and inefficient lysosomal tet

214 escribed drive induction of stress response, DNA repair, or estrogen-induced genes, and these pathway

215 ference and interpretable explanation of the DNA repair outcome following a Cas9 cutting.

216 Xi integrity and may, more broadly, predict DNA repair outcome in malignant cells.

217 NRAS single nucleotide variants [SNVs]), the DNA repair pathway (deletion 17p, TP53, and ATM SNVs), a

218 TRIP13 emerges as an important regulator of DNA repair pathway choice-promoting HDR, while suppressi

219 t large-scale genome organization influences DNA repair pathway choice.

220 suggesting that genomic location influences DNA repair pathway choice.

221 r by RIF1 and MAD2L2/Shieldin, to coordinate DNA repair pathway choices.

222 Nucleotide excision repair (NER) is a major DNA repair pathway for a variety of DNA lesions.

223 by germline loss-of-function mutations in FA DNA repair pathway genes.

224 associated with the homologous recombination DNA repair pathway or PARP inhibitor sensitivity, first

225 excision repair (BER) is the major cellular DNA repair pathway that recognises and excises damaged D

226 pathways, including E2Fs, Wnt, Myc, and the DNA repair pathway.

227 han the canonical non-homologous end joining DNA repair pathway.

228 onents integrate ASCC3/AlkBH3 into a complex DNA repair pathway.

229 earrangements by suppressing the insertional DNA repair pathway.

230 were associated with metabolic, apoptotic or DNA repair pathways (including APBA3, PARP1 and RAB11).

231 al malignancies must simultaneously activate DNA repair pathways and avoid the cell cycle arrest that

232 DNA glycosylase NEIL3 has been implicated in DNA repair pathways including the base excision repair a

233 in space and time to differentially regulate DNA repair pathways is insufficiently understood.

234 s - particularly cancers in which defects in DNA repair pathways make tumour cells highly sensitive t

235 on treatments that target RNA processing and DNA repair pathways simultaneously as effective cancer t

236 Cells possess an armamentarium of DNA repair pathways to counter DNA damage and prevent mu

237 Cells employ a variety of DNA repair pathways to protect themselves from these pro

238 ion of new series of compounds that modulate DNA repair pathways via a unique mechanism of action.

239 etion of USP22, enrichment of cell-cycle and DNA repair pathways was observed in the USP22-sensitive

240 The six major mammalian DNA repair pathways were discovered as independent proce

241 ubiquitin ligase with a key role in several DNA repair pathways, directly affects L1 retrotransposit

242 tin remodelling enzymes facilitate different DNA repair pathways, during different stages of the cell

243 al trials: Pathway inhibition, alteration of DNA Repair pathways, Immunotherapy, cancer Metabolism an

244 r genomic instability and promote defects in DNA repair pathways.

245 cacy of chemotherapeutic drugs by modulating DNA repair pathways.

246 GMs were evaluated in 127 genes from 6 major DNA repair pathways.

247 ring DNA replication, rather than by various DNA repair pathways.

248 that these cells require replication-coupled DNA-repair pathways, replication-stress signaling and re

249 he cNHEJ pathway play important roles in the DNA repair phase of CSR.

250 entifying known and novel cell-type-specific DNA repair phenotypes.

251 lved in unsaturated fatty acid biosynthesis, DNA repair, photoprotection, ionic homeostasis, osmotic

252 D, an important component of the error-prone DNA repair polymerase (Pol V), at very low levels in E.

253 volutionary paths converging to abolish this DNA repair process.

254 ic/apyrimidinic (AP) site that initiates the DNA repair process.

255 Yet, little is known about the cellular DNA repair processes that take place between radiation f

256 wild-type and homologous recombination (HR) DNA repair-proficient cancers, including central nervous

257 lts reveal how lncRNA effectively replaces a DNA repair protein for efficient NHEJ with implications

258 (c) sustaining the damage by inhibiting the DNA repair protein poly(ADP-ribose) polymerase (PARP).

259 oma cancer stem-like cells via inhibition of DNA repair protein RAD51 homolog 1 (RAD51).

260 We show that loss of the DNA repair protein XPA markedly augments the synthetic l

261 NAD(+) levels suppressed recruitment of the DNA repair protein XRCC1 to sites of genomic DNA damage

262 to two representative MDR proteins, MGMT (a DNA repair protein) and ABCB1 (an efflux protein), revea

263 resistance (MDR), generally caused by innate DNA repair proteins that reverse the DNA modification by

264 Recruitment of DNA repair proteins to DNA damage sites is a critical st

265 vival after additional knockdown of specific DNA repair proteins, including PARP1.

266 , DarG(Mtb) , forms a cytosolic complex with DNA-repair proteins that assembles independently of eith

267 to identify genes of the DNA damage response/DNA repair regime that when acutely depleted sensitize F

268 in (Ig) switch region, and serves as a novel DNA repair regulator of Ig class switch recombination (C

269 atures of processes such as transcription or DNA repair remain an open question.

270 e upstream regulator(s) of 53BP1 function in DNA repair remain unknown.

271 phosphorylation has a role in physiological DNA repair remains elusive.

272 s to DNA damage, but its precise function in DNA repair remains unknown.

273 mechanisms by which BRCA1-BARD1 functions in DNA repair, replication fork maintenance and tumour supp

274 ure-specific nuclease family are crucial for DNA repair, replication, and recombination.

275 atform for diverse nuclear processes such as DNA repair, replication, transcription, telomere, and ce

276 at XRN2 associates with proteins involved in DNA repair/replication (Ku70-Ku80, DNA-PKcs, PARP1, MCM2

277 Despite mobilizing the DNA repair response, even very low levels of DNA damage

278 tations impair homologous recombination (HR) DNA repair, resulting in cellular senescence and embryon

279 onized cleavage improved kinetic analysis of DNA repair, revealing that cells respond to Cas9-induced

280 ve phosphorylation, hypersensitive response, DNA repair, stomata closure, biosynthesis of secondary m

281 tively, our study suggests LRRC31 as a major DNA repair suppressor that can be targeted for cancer ra

282 Here, we report a DNA repair suppressor, leucine-rich repeat-containing pr

283 correct point mutations without supplying a DNA-repair template.

284 me plasticity is rooted in the mechanisms of DNA repair that parasites employ to maintain genome inte

285 support a significant role for both genes in DNA repair that was not previously described.

286 enes to hereditary disorders with defects in DNA repair, the replication stress response, and/or tran

287 iated homologous DNA pairing and HR-mediated DNA repair, the role of DNA binding by UAF1 in these pro

288 rategies upon association with inhibitors of DNA repair, thus paving the way toward innovative drug c

289 However, the factors stimulating DNA repair to stave off functional decline remain obscur

290 ch reveals insights into the contribution of DNA repair towards indel mutagenesis in human cells.

291 and cell cycle control, signal transduction, DNA repair, transcription, and many others.

292 pairing mediated by the recombinase RAD51 in DNA repair via the homologous recombination (HR) pathway

293 By analogy to DNA repair, we propose that the ability of FACT to both

294 c-Jun and STAT3 as well as proliferation and DNA repair were analyzed by western blotting, electropho

295 hat activation of c-Jun and STAT3 as well as DNA repair were induced by an extract from schistosome e

296 Moreover, elevated levels of DNA repair were observed in Cas9-expressing cell lines.

297 in areas well beyond the historical focus on DNA repair, which are having impacts on the understandin

298 TERC, confers genomic stability and promotes DNA repair, which have considerable physiological and pa

299 y required for homologous recombination (HR) DNA repair, which is mechanistically distinct from Ino80

300 Enzymatic processing of DNA underlies all DNA repair, yet inappropriate DNA processing must be avo