ライフサイエンスコーパス: DNA replication

1 lyzed the consequences of PDS5 depletion for DNA replication.

2 capsid protein (VP)-encoding mRNAs and viral DNA replication.

3 ) of USP13; and occurs preferentially during DNA replication.

4 chromatids precisely as they are born during DNA replication.

5 er eukaryotic cell-cycle kinases controlling DNA replication.

6 nd strength, biological motor operation, and DNA replication.

7 histone chaperone, as FACT also functions in DNA replication.

8 ped proteins that increase the efficiency of DNA replication.

9 ll-cycle progression, DNA damage repair, and DNA replication.

10 reestablish centromeric chromatin following DNA replication.

11 nce protein complex, around DNA and initiate DNA replication.

12 or ICL repair in metazoans and is coupled to DNA replication.

13 nimise replication stress and promote normal DNA replication.

14 /G2 phase to ensure adequate dNTP supply for DNA replication.

15 quadruplex regions that impede mitochondrial DNA replication.

16 etic and mechanistic basis for high-fidelity DNA replication.

17 r maintaining sufficient dNTPs during normal DNA replication.

18 o interact with treslin, leading to enhanced DNA replication.

19 the leading strand, which is dispensable for DNA replication.

20 lity of Orc6 and result in reduced levels of DNA replication.

21 PHF8 regulates TopBP1 stability to maintain DNA replication.

22 shment of the methylation sequence following DNA replication.

23 ut little is known about its dynamics during DNA replication.

24 including Topoisomerase-DNA adducts, during DNA replication.

25 and associates with proteins known to act in DNA replication.

26 pre-replicative complex and is essential for DNA replication.

27 catenated circular chromosomes generated by DNA replication.

28 ruitment of replication factor C to initiate DNA replication.

29 y introducing nicking damage to impair phage DNA replication.

30 d secondary structures, gene expression, and DNA replication.

31 2/NuRD to transcriptionally silence REs post-DNA replication.

32 ntial A protein that mediates rolling-circle DNA replication.

33 cell cycle activation, immune responses and DNA replication.

34 11, 17, 20, and 58 inhibit later steps after DNA replication.

35 ction in helping to clear R-loops that block DNA replication.

36 s residence time on chromatin and slows down DNA replication.

37 hat also have the potential to impede timely DNA replication.

38 NA, epigenetic maintenance and regulation of DNA replication.

39 1) phase causes an early switch and inhibits DNA replication.

40 e, we report that TtAgo also participates in DNA replication.

41 ular insights into a key event of eukaryotic DNA replication.

42 s at individual replication forks undergoing DNA replication.

43 tly-occurring lesions that uniquely threaten DNA replication.

44 th DNA to produce DNA lesions that may block DNA replication.

45 pair (MMR) corrects errors that occur during DNA replication.

46 encoding capsid proteins as well as in viral DNA replication.

47 en-induced mouse liver tumours and show that DNA replication across persisting lesions can produce mu

48 chanistically, 6-4PPs, but not CPDs, impeded DNA replication across the genome as revealed by microfl

49 nesis, with a focus on the specific steps of DNA replication affected in these human diseases.

50 n reactivation probability is due to reduced DNA replication after flowering.

51 Telomeres are a significant challenge to DNA replication and are prone to replication stress and

52 Unlike many rapidly growing bacteria, DNA replication and cell division are temporally resolve

53 ure is driven by dynamic competition between DNA replication and chromosomal relaxation, providing a

54 They result, at least in part, from DNA replication and chromosome segregation errors due to

55 otect vulnerable DNA bases and to facilitate DNA replication and compaction.

56 rlying conserved cellular functions, such as DNA replication and cytokinesis.

57 tify a major epigenetic mechanism regulating DNA replication and directly linking replication origin

58 ly of nucleosomes during gene transcription, DNA replication and DNA repair(2).

59 as it plays important roles in latent viral DNA replication and efficient segregation of the viral g

60 DNA replication or repair complexes, such as DNA replication and end resection machinery, and stimula

61 It is required for DNA replication and essential for viability in all speci

62 new role for LSD1 in the regulation of HSV-1 DNA replication and gene expression after the onset of D

63 us is of vital importance for transcription, DNA replication and genome maintenance.

64 otide pool is essential for high accuracy of DNA replication and is critical for retaining the genomi

65 n of the TNR within the FRAXA locus perturbs DNA replication and is the major causative factor for fr

66 are strongly associated with cell cycle and DNA replication and linked to a coordinated module of ex

67 ved in several cellular processes, including DNA replication and metabolism.

68 ose a frequent and significant impediment to DNA replication and must be actively managed in order to

69 portant roles in gene expression regulation, DNA replication and repair etc.

70 DNA2 is an essential enzyme involved in DNA replication and repair in eukaryotes.

71 S stability may be compromised by incomplete DNA replication and repair in TAD boundaries core fragil

72 functions in both nuclear and mitochondrial DNA replication and repair processes, preferentially unw

73 ne signaling, whereas CDK6 mainly controlled DNA replication and repair processes.

74 by its interactions with distinct groups of DNA replication and repair proteins and by post-translat

75 a structure-specific nuclease with roles in DNA replication and repair, and has the greatest number

76 resence of R-loops contributes to defects in DNA replication and repair, gene expression, and genomic

77 , they play an important role in fidelity of DNA replication and repair.

78 propagation of life requires coordination of DNA replication and segregation with cell growth and div

79 atures of two chromosome metabolism modules, DNA replication and sister chromatid cohesion, and inact

80 Despite DNA replication and subsequent condensation of chromatin

81 new role for LSD1 in the regulation of viral DNA replication and successive steps in the virus life c

82 To examine the established link between DNA replication and telomere length, we tested whether f

83 ivity on the strand-specific role of Pole in DNA replication and the action of extrinsic correction s

84 cell's genomic DNA, generally independent of DNA replication and the cell cycle.

85 e BLM helicase protein plays a vital role in DNA replication and the maintenance of genomic integrity

86 triphosphates (dNTPs) and essential for both DNA replication and the repair of DNA damage.

87 e problematic for the essential processes of DNA replication and transcription because they deter nor

88 s) are a toxic form of DNA damage that block DNA replication and transcription by tethering the oppos

89 Top2 and the HMGB family protein Hmo1 assist DNA replication and transcription(3-6).

90 perform critical cellular functions such as DNA replication and transcription, DNA supercoiling, int

91 Unrepaired SSBs impair DNA replication and transcription, leading to cancer and

92 ) regulates DNA topology to ensure efficient DNA replication and transcription.

93 of DNA-protein crosslinks (DPCs) and causes DNA replication and transcriptional stress.

94 ations in DNA and misincorporation errors in DNA replication and translation.

95 immunoblotting, proximity ligation, replicon DNA replication and whole virus immunofluorescence assay

96 e compounds 14 and 60 likely target the HAdV DNA replication, and 11, 17, 20, and 58 inhibit later st

97 ignals that regulate cell cycle progression, DNA replication, and cell survival.

98 y vital roles in regulating gene expression, DNA replication, and DNA and histone modifications.

99 of chromatin dynamics during transcription, DNA replication, and DNA repair.

100 the proper control of viral gene expression, DNA replication, and genome copy number.

101 nBu-PTEs at XT sites did not strongly impede DNA replication, and other nBu-PTEs displayed moderate b

102 d is necessary for IE gene expression, viral DNA replication, and reactivation from latency.

103 -depletion of Mdm4 and Mdm2 further impaired DNA replication, and the overexpression of each partiall

104 C by 2-3 h; (v) Multiple processes including DNA replication, and the ubiquitin and proteasome pathwa

105 Pyrimidine synthetic genes peaked during DNA replication, and their depletion caused a filamentat

106 lication, gene expression after the onset of DNA replication, and virus production.

107 Both BB assembly and DNA replication are tightly coordinated with the cell cy

108 igase complex 4 (CRL4), known for modulating DNA replication, as a crucial mitotic regulator that tri

109 for 24 h with TAF still inhibited EBV lytic DNA replication at 72 h after drug was removed.

110 POLD3, a protein critical for break-induced DNA replication (BIR).

111 During DNA replication, both genetic information and chromatin

112 nto the lagging strand, which is crucial for DNA replication but dispensable for sister chromatid coh

113 Human and bacterial Lon proteases regulate DNA replication by degrading replication initiation fact

114 ription of the MCM6 gene that is involved in DNA replication by directly binding to specific motifs w

115 inhibited cell-cycle progression and reduced DNA replication by disrupting the formation of the minic

116 y of Mdm2 to modify chromatin and to support DNA replication by suppressing the formation of R-loops

117 , E2F-dependent transcription determines the DNA replication capacity of a cell, which affects the re

118 thods show that the kinetics and fidelity of DNA replication catalyzed by the labeled enzyme are larg

119 d included increases in proteins involved in DNA replication, cell cycle, RNA processing, and chromos

120 ts that animal cell Y RNAs are essential for DNA replication, cells lacking these RNAs divide normall

121 They are required to mediate the DNA replication checkpoint (DRC), the stable pausing of

122 thologue of ATR and the sensor kinase of the DNA replication checkpoint in Schizosaccharomyces pombe

123 ribute to regulation of TopBP1 stability and DNA replication checkpoint.

124 DNA replication, chromatin dynamics, cellular signaling,

125 We analyzed whether defects in DNA replication contribute to genomic instability and th

126 duplicate only once in coordination with the DNA replication cycle and have an important role in segr

127 Reprogramming of DNA replication did not correlate with DNA methylation.

128 As a result, treated cells show slower DNA replication, DNA damage checkpoint activation, and a

129 In eukaryotic DNA replication, DNA polymerase epsilon (Polepsilon) is

130 eficient cells, and identified regulation of DNA replication dynamics as an important mechanistic con

131 readth is demonstrated by creating models of DNA replication dynamics, the gene expression dynamics i

132 of nuclear functions including initiation of DNA replication, epigenetic maintenance and associates w

133 y at a rate similar to those of other common DNA replication errors (i.e. ribonucleotide and mismatch

134 age, rather are caused, at least in part, by DNA replication errors.

135 mutagens in the environment or by endogenous DNA-replication errors in tissue stem cells.

136 RECQ4 is a DNA replication factor important for mtDNA maintenance,

137 In human cells, the DNA replication factor proliferating cell nuclear antige

138 ymerases is a fundamental mechanism ensuring DNA replication fidelity.

139 stability to ensure the viable completion of DNA replication following replication stress.

140 sulted in a dose-dependent increase in viral DNA replication for BKV, MCV and HPyV7.

141 ggered by DNA damage in bacteria, depends on DNA replication for the generation of the SOS signal, ss

142 The replisome is a protein complex on the DNA replication fork and functions in a dynamic environm

143 k identifies CtIP as a critical regulator of DNA replication fork integrity, which, when compromised,

144 n of Mdm4 in p53-deficient cells compromises DNA replication fork progression as well.

145 by SA1 and SA2 to 3D chromatin organization, DNA replication fork progression, and DNA double-strand

146 ic or induced by interferon-beta, accelerate DNA replication fork progression, resulting in extensive

147 s, only full-length Mdm4 was able to support DNA replication fork progression.

148 ective sister chromatid cohesion and reduced DNA replication fork speed.

149 d DNA synthesis, and the recovery of stalled DNA replication forks (RFs).

150 in DNA repair and the protection of stalled DNA replication forks are thought to underlie the chemos

151 air by homologous recombination and protects DNA replication forks from attrition.

152 leterious nucleolytic degradation of stalled DNA replication forks in a manner similar to that of cel

153 In bacteria, the restart of stalled DNA replication forks requires the DNA helicase PriA.

154 in the interactions between PriA and stalled DNA replication forks with or without SSB.

155 PriA can recognize and remodel abandoned DNA replication forks, unwind DNA in the 3'-to-5' direct

156 lization of RAD51 nucleofilaments at damaged DNA replication forks.

157 nd concomitant loss of cohesion, possibly at DNA replication forks.

158 es mirroring previously examined fluorescent DNA replication fusion proteins.

159 -1-infected cells with SP-2509 blocked viral DNA replication, gene expression after the onset of DNA

160 Recent studies of bacterial DNA replication have led to a picture of the replisome a

161 odulation of viral mRNA processing and viral DNA replication.IMPORTANCE Human bocavirus 1 (HBoV1) is

162 ation and gene expression after the onset of DNA replication.IMPORTANCE Treatment of HSV-1-infected c

163 s the potential for on target examination of DNA replication in a wide range of biological contexts.

164 mportant role for TopBP1 in driving abnormal DNA replication in cancer.

165 or G), and assessed how these lesions impact DNA replication in Escherichia coli cells.

166 DNA replication in eukaryotic cells initiates from repli

167 describe previously undetected subtelomeric DNA replication in G2/M and G1-phase-enriched cells.

168 ique single-molecule approach, we visualized DNA replication in isogenic PSCs generated by different

169 DNA replication in mammalian cells occurs in a defined t

170 provide a detailed temporal choreography of DNA replication in mammalian cells.

171 estions on chromosome biology in general and DNA replication in particular.

172 A subsequent burst of DNA replication in the next mitosis generates extensive

173 O80-dependent resolution of R-loops promotes DNA replication in the presence of transcription, thus e

174 kdown, suggesting that FACT functions during DNA replication in tumor cells but not in normal cells.

175 frequently dissociate from replisomes during DNA replication in vivo.

176 accumulated preferentially at 6-4PPs during DNA replication, indicating selective and prolonged repl

177 DNA replication initiates from multiple genomic location

178 Previous work in Leishmania detected DNA replication initiation at just a single region in ea

179 by different cell types and host ~80% of all DNA replication initiation events in any cell population

180 us, which corresponds with previously mapped DNA replication initiation regions and is demarcated by

181 Eukaryotic DNA replication initiation relies on the origin recognit

182 nism essential for replisome assembly during DNA replication initiation that is vulnerable to inhibit

183 ed, kinase-independent function for AURKA in DNA replication initiation whose inhibition through a cl

184 to support predominantly chromosome-internal DNA replication initiation within S phase.

185 e duplication programme employs subtelomeric DNA replication initiation, possibly extending beyond S

186 t TopBP1-treslin interaction is critical for DNA replication initiation.

187 -subunit origin recognition complex (ORC), a DNA replication initiator, defines the localization of t

188 Replication Protein A (RPA) is critical for DNA replication integrity.

189 DNA replication is a ubiquitous and conserved cellular p

190 Protecting replication fork integrity during DNA replication is essential for maintaining genome stab

191 tion of the replicative H3 variant following DNA replication is essential for the transmission of the

192 DNA replication is essential to couple genome duplicatio

193 DNA replication is fundamental for cell proliferation in

194 DNA replication is highly regulated by the ubiquitin sys

195 Meanwhile, DNA replication is intrinsically linked to the process o

196 DNA replication is needed to duplicate a cell's genome i

197 These results suggest that PLE DNA replication is one of multiple mechanisms contributi

198 However, regulation of DNA replication is only understood in a small fraction o

199 In eukaryotes, DNA replication is performed by a large machine known as

200 We propose that break-induced DNA replication is required for the replication of FRAXA

201 In addition, DNA replication is required to maintain full Pol II occu

202 DNA replication, unlike chromosome-internal DNA replication, is sensitive to hydroxyurea and depende

203 We investigated if PLE DNA replication itself is antagonistic to ICP1 replicati

204 However, SP-2509 does inhibit viral DNA replication, late gene expression, and virus product

205 Collisions between the DNA replication machinery and co-transcriptional R-loops

206 how alkyl-PTE lesions are recognized by the DNA replication machinery in prokaryotic cells and revea

207 fferentiation proficiency of PSCs, analyzing DNA replication may be a useful quality control tool.

208 and then, at night, undergo rapid cycles of DNA replication, mitosis, and cell division, producing u

209 ase is blocked by nocodazole, which inhibits DNA replication, mitosis, and cell division; this sugges

210 ity of these models is shown by adapting the DNA replication model to further include two topics of i

211 Despite restoration of ICP1 DNA replication, non-replicating PLE remained broadly in

212 ial processes such as gene transcription and DNA replication occur.

213 avage assay, we studied LexA cleavage during DNA replication of both undamaged and base-damaged templ

214 r B cell development, and others result from DNA replication or aberrant repair of breaks in sequence

215 nd when Mus81-Mms4 and Yen1 nucleases act on DNA replication or recombination structures.

216 echanisms induce its recruitment to specific DNA replication or repair complexes, such as DNA replica

217 n recruit and load enough MCM2-7 to initiate DNA replication, or human cell lines can sometimes recru

218 e function of multiple spatially distributed DNA replication origins for its stable inheritance.

219 The selection and firing of DNA replication origins play key roles in ensuring that

220 DNA replication origins serve as sites of replicative he

221 n the structure and function of the archaeal DNA replication origins, the proteins that define them,

222 mmary, SMC5/6 is important for completion of DNA replication prior to entering mitosis, which ensures

223 compounds 6 and 43 possibly target the HAdV DNA replication process, while compounds 46 and 47 suppr

224 nism for bypassing DNA lesions that obstruct DNA replication progression.

225 small-RNA-directed non-CG methylation during DNA replication promotes germline reprogramming and epig

226 with rolling circle and rolling circle-like DNA replication proteins.

227 ysis revealed that contractions occur during DNA replication, rather than by various DNA repair pathw

228 ns are readily visualized in single-molecule DNA replication reactions.

229 cyclin-dependent kinase 9 activity and viral DNA replication reduced Pol II on the viral genome and r

230 eJA-treatment of Arabidopsis in altering the DNA replication regulator CDC6, supporting conservation,

231 nscription factors (Myc, E2F1, TBX2, FOXM1), DNA replication regulators (CDKN1A, EZH2, RRM2), G1/S-tr

232 P1 regulation and how its regulation affects DNA replication remain unknown.

233 Strand slipped hairpins during DNA replication, repair and/or recombination may contrib

234 olic processes that involve ssDNA, including DNA replication, repair, and damage signaling.

235 Multiple CDK6 DNA replication/repair genes were not only associated wi

236 distinct signaling pathways and reveals the DNA replication/repair pathway as central in promoting t

237 ncovered novel connections to cell division, DNA replication/repair, signal transduction, and glutath

238 During DNA replication, replicative DNA polymerases may encount

239 is established, maintained or changed during DNA replication represents a fundamental question in bio

240 ic for the expanded allele, independently of DNA replication, require transcription across the coding

241 Successful DNA replication requires carefully regulated mechanisms

242 Complete and accurate DNA replication requires the progression of replication

243 DNA replication requires the sliding clamp, a ring-shape

244 ription-coupled homologous recombination and DNA replication restart.

245 DNA replication results in an increase in DNA copy numbe

246 d on these observations, initiation of plant DNA replication shows some similarity to, but is also di

247 T1 physically associates with chromatin near DNA replication sites.

248 eraction with SSB localizes RNase HI foci to DNA replication sites.

249 e to sublethal ethanol concentrations causes DNA replication stress and an increased mutation rate.

250 uitination by USP36 plays a critical role in DNA replication stress and chemotherapy response.

251 is a cytidine deaminase driving mutagenesis, DNA replication stress and DNA damage in cancer cells.

252 disrupts cell-cycle progression and induces DNA replication stress and genome instability in small c

253 output in susceptible cell types can elicit DNA replication stress and may promote genomic instabili

254 V39H1 inhibition reactivated REs, leading to DNA replication stress and stimulation of MAVS/STING ant

255 on, and their inhibition selectively induces DNA replication stress and viral mimicry in cancer cells

256 demonstrated that absence of SMC5/6 leads to DNA replication stress at late-replicating regions such

257 DNA replication stress can stall replication forks, lead

258 ly evolved cells constitutively experiencing DNA replication stress caused by the absence of Ctf4, a

259 to dihydromyricetin triggered DPCs-dependent DNA replication stress in cancer cells.

260 in vitro and in vivo elicited biomarkers of DNA replication stress or double-strand breaks.

261 including elevated microtubule dynamics and DNA replication stress that can be partially rescued to

262 ne activation during tumorigenesis generates DNA replication stress, a known driver of genome rearran

263 Defective RRM1 S559 phosphorylation causes DNA replication stress, double-strand break, and genomic

264 stically, USP36 is deubiquitinated following DNA replication stress, which in turn facilitates its up

265 ing mechanical deformation of the nucleus to DNA replication stress.

266 Here, using a DNA replication system reconstituted in vitro in tandem

267 Using the reconstituted budding yeast DNA replication system, we find that the flexible N-term

268 and R-loops using a reconstituted bacterial DNA replication system.

269 ngs highlight the evolution and diversity of DNA replication systems and provide insights into the re

270 volved in the regulation of gene expression, DNA replication, the cell cycle, and the DNA damage resp

271 Concomitant with DNA replication, the chromosomal cohesin complex establi

272 During DNA replication, the genetic information of a cell is co

273 During DNA replication, the presence of 8-oxoguanine (8-oxoG) l

274 -stranded DNA-binding protein RPA, efficient DNA replication through either a Reb1 or a nucleosome bl

275 and functional evidence for the emergence of DNA replication through the evolution of an ancestral RN

276 inks Cdk2 and Akt pathways to the control of DNA replication through the regulation of TopBP1-treslin

277 recruited to replication factories, sites of DNA replication, through interaction with PCNA.

278 , we explore the transcriptional profile and DNA replication timing (RT) under mild replication stres

279 DNA replication timing is tightly regulated during S-pha

280 at the replication fork, beyond the needs of DNA replication, to promote establishment of sister chro

281 ions required for virus viability including, DNA replication, transcription regulation, genome packag

282 and can maintain/modulate the efficiency of DNA replication, transcription, and DNA repair.

283 Nuclear processes such as DNA replication, transcription, and RNA processing each

284 We also review the known pathways in which DNA replication, transcription, DNA repair, and chromati

285 t pathways controlled by (pp)pGpp, including DNA replication, transcription, nucleotide synthesis, ri

286 the single-molecule level to examine lambda DNA replication, transcription, virion assembly, and res

287 Similar to DNA replication, translation of the genetic code by the

288 a mechanistic understanding of an aspect of DNA replication unique to eukaryotic cells.

289 Finally, we show that subtelomeric DNA replication, unlike chromosome-internal DNA replicat

290 nt natural and nonnatural stimuli (errors in DNA replication, UV radiation, chemical agents, etc.) is

291 contexts of 5'-AT-3', 5'-CT-3', or 5'-GT-3', DNA replication was highly efficient and the replication

292 n PSCs with lower differentiation potential, DNA replication was incompletely reprogrammed, and genom

293 Following pre-meiotic DNA replication, we blocked autophagy by chemical inhibi

294 lved in aerobic respiration or mitochondrial DNA replication were either absent or present only as ps

295 reaks in PSCs with incompletely reprogrammed DNA replication were found.

296 mispaired eG contexts, which can form during DNA replication, were similarly poor substrates for AAG.

297 -quadruplexes represent unique roadblocks to DNA replication, which tends to stall at these secondary

298 s, bacteria maintain critical processes like DNA replication while removing misfolded proteins, which

299 t MCM2-7 normally to chromatin, and initiate DNA replication with normal number of origins.

300 ically for HIV prevention, inhibit EBV lytic DNA replication, with respective IC(50) values of 0.30 m