ライフサイエンスコーパス: DNA sequence

1 ype, age, the timing of experience, sex, and DNA sequence.

2 MeCP2 in vitro and defined a minimal target DNA sequence.

3 expression but are not related to changes in DNA sequence.

4 ically inherited independently of underlying DNA sequence.

5 c variants specifies methylation of a unique DNA sequence.

6 predicts genome folding from megabase-scale DNA sequence.

7 ch of the DNA-binding species for its target DNA sequence.

8 BL-bound promoters were enriched for GC-rich DNA sequences.

9 orted to have an affinity for non-methylated DNA sequences.

10 from binding to the minor groove of AT-rich DNA sequences.

11 architecturally mosaic genomes with distinct DNA sequences.

12 have a rich history in the classification of DNA sequences.

13 e target genes by specific interactions with DNA sequences.

14 f thousands of CRISPR RNA (crRNA) and target DNA sequences.

15 ies of the nucleosomes containing non-native DNA sequences.

16 e complete erasure of information encoded in DNA sequences.

17 tive endoderm cells, screening 7905 distinct DNA sequences.

18 repeated measurements with several different DNA sequences.

19 ate mutant knockout collections or diversify DNA sequences.

20 nimal skins to "fingerprint" pieces based on DNA sequences.

21 romatin accessibility solely from regulatory DNA sequences.

22 omoters is primarily associated with GC-rich DNA sequences.

23 u-Ag nanocrystals synthesized with different DNA sequences.

24 cannot consistently transcribe through long DNA sequences.

25 structures of nucleosomes containing native DNA sequences.

26 tiple displacement amplification and shotgun DNA sequencing.

27 he double-digest restriction site-associated DNA sequencing.

28 e-oxidizing microorganisms was determined by DNA sequencing.

29 ones containing background plasmids prior to DNA sequencing.

30 hich transport cargo across membranes, as in DNA sequencing.

31 nsitivity and specificity by next generation DNA sequencing.

32 dds adapters ('tagmentation') for paired-end DNA sequencing.

33 al microbiome were analyzed by 16S ribosomal DNA sequencing.

34 ds by read-through reverse transcription and DNA sequencing.

35 irectly identified by PCR without a need for DNA sequencing.

36 ownstream PCR-mediated DNA modifications and DNA sequencing.

37 oftware maps a desired circuit function to a DNA sequence, a process that requires units of gene regu

38 erstand how naturally occurring variation in DNA sequences affects complex organismal traits through

39 This presents an opportunity for DNA sequence alignment software to exploit high-concurre

40 that accurately predicts genome folding from DNA sequence alone.

41 SPACE expands the range of possible DNA sequence alterations, broadening the research applic

42 osome conformation capture (Hi-C) along with DNA sequence analysis, we demonstrate that most SEs are

43 of these two qPCR products was confirmed by DNA sequencing analysis, which showed 99-100% similarity

44 ynthesize available evidence on the roles of DNA sequence and DNA topology in controlling R-loop form

45 t model accounting for the interplay between DNA sequence and DNA topology in driving R-loop structur

46 hat viral genome packaging is insensitive to DNA sequence and fluctuations in packaging motor velocit

47 he contribution of other chromatin proteins, DNA sequence and histone modifications is less understoo

48 The DNA sequence and organization of the sequence elements a

49 These days, enormous amounts of DNA sequence and other omics data are generated.

50 tion, 89 sequence features were derived from DNA sequence and protein sequence for each gene.

51 LEX-seq experimental results, we deduced the DNA sequence and shape determinants of MEF2B target site

52 bles the precise modification of any desired DNA sequence and surpasses all hitherto existing alterna

53 he ligation efficiency is influenced by both DNA sequence and the incubation conditions.

54 ngs argue that MeCP2 does not read unadorned DNA sequence and therefore support the notion that its p

55 genome organization requires integration of DNA sequence and three-dimensional spatial context; howe

56 is favored to partners with the most similar DNA sequences and can be discriminated based on cryptic

57 nsion due to polymerase slippage at repeated DNA sequences and point mutations caused by error-prone

58 h amplifiers require the intricate design of DNA sequences and reaction conditions.

59 HIV RNA and DNA sequences and therapeutic antiretroviral plasma leve

60 r genomic features by use of next-generation DNA sequencing and characteristics of the tumour microen

61 By combining long-read DNA sequencing and Hi-C, we assembled the sex-determinin

62 Integrated 16S ribosomal DNA sequencing and liquid chromatography coupled tandem

63 Additionally, time series DNA sequencing and replay evolution experiments revealed

64 Bioaerosols were analyzed by metagenomic DNA sequencing and traditional culturing methods to char

65 ter simulations leveraging field trial data, DNA sequences, and historical weather records can be use

66 combination with restriction site-associated DNA sequencing, and for diploid Ipomoea trifida and auto

67 , we develop an unbiased whole-genome plasma DNA sequencing approach that concurrently measures genom

68 Using targeted single-cell DNA sequencing approaches, two articles in Nature and Na

69 together with RPA, fundamentally alters how DNA sequences are aligned during HR.

70 l HR machinery to an active process in which DNA sequences are aligned via an ATP-dependent molecular

71 family members revealed that the FKH and FHL DNA sequences are bound in two distinct modes, with part

72 Gut microbiota data obtained by DNA sequencing are complex and compositional because of

73 monstrates the potential of using functional DNA sequences as a versatile and tunable capping ligand

74 posed modifications to the ICNP to recognize DNA sequences as acceptable type material; the other opt

75 xhibit prominent decondensation of satellite DNA sequences at metaphase and increased sister chromati

76 We performed tumor DNA sequencing at 42 clinically relevant genetic loci to

77 Molecular response measured by cell-free DNA sequencing at day 7 after infusion was significantly

78 able component known to not be restricted to DNA sequence-based genetic inheritance alone but to also

79 pathway or-especially in the case of AT-rich DNA sequences-be transcribed and initiate MAVS-dependent

80 ive genomics research is modeling changes in DNA sequences between species to understand the evolutio

81 of double-digest restriction-site associated DNA sequencing (BSA-ddRADseq) was developed and used to

82 andida albicans form on unique and different DNA sequences but a closely related species, Candida tro

83 romise in predicting regulatory effects from DNA sequence, but their informativeness for human comple

84 We validated regulatory DNA sequences by mobility shift assays and with lucifera

85 switch between these roles is regulated by a DNA sequence called Chi.

86 RNA polymerases initiate transcription at DNA sequences called promoters.

87 Guanine-rich DNA sequences can fold into four-stranded G-quadruplex (

88 ng the way to cost-effective single-molecule DNA sequencing, capable of handling widely varying GC-bi

89 Centromeres are built on repetitive DNA sequences (CenDNA) and a specific chromatin enriched

90 t a rate approximately 25 times greater than DNA sequence changes and typically have short half-lives

91 recipitation coupled with massively parallel DNA sequencing (ChIP-seq) and coimmunoprecipitation expe

92 DNA-sequence comparisons used single nucleotide variants

93 Within nucleosomes, stiff DNA sequences confer spontaneous partial unwrapping, pro

94 increased the association of RBPJkappa with DNA sequences containing HIF-1alpha-binding sites.

95 oxa2, results in changes to accessibility in DNA sequences containing their respective DNA-binding mo

96 zed target libraries, with strong nicking of DNA sequences containing up to four mismatches in the Ca

97 specific and is found mainly in two separate DNA sequence contexts: GA and GGC.

98 ization that the inference of selection from DNA sequence data first requires a robust model of popul

99 nferred a phylogeny of the two species using DNA sequence data from four nuclear genes (Abd-A, EF1alp

100 In an analysis of clinical and DNA sequence data from patients with Lynch syndrome from

101 standard of data sharing of metagenomes and DNA sequence data more broadly.

102 aps in capacity to generate large volumes of DNA sequence data, which has spurred a rapid growth in t

103 ltering small genomic variants in short-read DNA sequence data.

104 rs cancer karyotypes that better explain the DNA sequencing data and conform to a reasonable evolutio

105 logenies from ultra-low-coverage single-cell DNA sequencing data and helps estimate CNA rates in a la

106 Tumor DNA sequencing data can be interpreted by computational

107 f one or more rearranged cancer genomes from DNA sequencing data from a bulk tumor sample.

108 We have developed a tool that simulates DNA sequencing data from hierarchically grouped (correla

109 The DNA sequencing data generated by our simulator is repres

110 d to obtain the data to analyze: Single Cell DNA Sequencing data have great specificity, but are affe

111 The combination of bulk and single-cell DNA sequencing data of the same tumor enables the infere

112 s become possible to collect next-generation DNA sequencing data sets that are composed of multiple s

113 ent state-of-the-art methods on multi-sample DNA sequencing data that we simulate using MASCoTE (Mult

114 curate copy number profiles from single-cell DNA sequencing data.

115 d specifically for or adapted to single-cell DNA sequencing data.

116 ng and analyzing restriction site-associated DNA sequence datasets using de novo and/or reference-bas

117 ia double digest restriction-site associated DNA sequencing (ddRAD).

118 DNA sequencing demonstrates these are two independent tu

119 ogether, these findings explain the distinct DNA sequence-dependencies of metazoan and S. cerevisiae

120 for biological and practical requirements in DNA sequence design often results in challenging optimiz

121 Yet, how the DNA sequence determines which TF complex forms at any gi

122 between transcription factors and regulatory DNA sequence dictate rates of transcription and, ultimat

123 , these data demonstrate that the downstream DNA sequence directly impacts the kinetics of transcript

124 In metazoa, DNA sequence elements involved in origin specification r

125 Structural variants (SVs) that alter DNA sequence emerge as a driving force involved in the r

126 Still, how a given DNA sequence encodes a particular locus-specific folding

127 SHM introduces DNA sequences encoding N-glycosylation sites asparagine-

128 icate whether the concentrations of specific DNA sequences exceed respective threshold values.

129 atial proximity of the homologous centromere DNA sequences facilitated karyotype rearrangements and c

130 patterns are not simply driven by intrinsic DNA sequence features but most likely also reflect DNA t

131 MT1, revealing a pronounced influence of the DNA sequences flanking the target CpG site on DNMT1 acti

132 inherited hearing loss, panel-based genomic DNA sequencing, followed by segregation analysis of larg

133 omere inactivation accompanied by changes in DNA sequence following chromosome-chromosome fusion.

134 PCR also enabled the generation of specific DNA sequences for DNA engineering up to 11 kilo base pai

135 ng might facilitate the generation of mutant DNA sequences for protein engineering and the functional

136 p53 and mismatch repair (MMR) proteins, and DNA sequencing for POLE exonuclease domain were done to

137 Nugent) scores for BV, Candida cultures and DNA sequencing for VVC, and a composite of NAAT and cult

138 Alignment of DNA sequences from an unrelated Ashkenazi individual to

139 Tumor DNA sequences from APOBEC3A-expressing animals display h

140 analysis was conducted using six chloroplast DNA sequences from leaf material from across the BI and

141 ve immunity relies on the insertion of short DNA sequences from parasite genomes into CRISPR arrays o

142 scriptional activators that bind to specific DNA sequences from which they stimulate transcription.

143 Here, we use bacterial DNA sequencing from serially collected vaginal samples f

144 rived xenografts (PDX) and subjected them to DNA sequencing, gene expression profiling, and high-thro

145 Bulk and single-cell DNA sequencing has enabled reconstructing clonal substru

146 Advances in DNA sequencing has made available the complete set of ge

147 Advances in DNA sequencing have offered researchers an unprecedented

148 Advances in DNA sequencing have revolutionized our ability to read g

149 igh level of taxonomic resolution offered by DNA sequencing (i.e., species to sub-species level) prov

150 if motor function is modulated by substrate DNA sequence: (i) the phage T4 motor exhibits large tran

151 utations, and gene conversions which disrupt DNA sequence identity within IBD segments, and it can be

152 erdependent with, rather than separate from, DNA sequence; (ii) precise mechanisms vary phylogenetica

153 veral data sources - including spectroscopy, DNA sequences, image recognition, and morphological data

154 site-specific integration of kilobase-sized DNA sequences in bacteria are limited by low efficiency,

155 Inverted duplicate DNA sequences in both yeast and human samples were obser

156 DNA sequences in regulatory regions and in telomers at t

157 tem of reporter enzymes that cleave specific DNA sequences in solution, which results in an electroch

158 data by more fully characterizing satellite DNA sequences in the Saimiri genus.

159 silencing of many retroviruses by binding to DNA sequences in the U3 region of the viral long termina

160 ion factor family that bind nearly identical DNA sequences in vitro.

161 its efficiency for the introduction of large DNA sequences in zygotes is low.

162 High throughput DNA sequencing in combination with efficient algorithms

163 The acceleration of DNA sequencing in samples from patients and population s

164 e found that A(20)R(20)-AuNPs (R(20): random DNA sequence including A, T, C, and G) had the strongest

165 The proportion of identical HIV-1 DNA sequences increased within PB-derived T(EM) cells.

166 profile prediction by using short windows of DNA sequences independently.

167 e Atlas Breast Cancer Project, somatic LRRK2 DNA sequence information was obtained for 93 cases, of w

168 rates in a gene-specific manner, maintaining DNA sequence integrity for the bulk of genes but allowin

169 that this widespread transcription maintains DNA sequence integrity in the male germline by correctin

170 e results highlight the intricacy of protein-DNA sequence interactions within the seemingly similar t

171 The underlying centromeric DNA sequence is largely dispensable, yet paradoxically,

172 tif at 1.6 angstrom resolution, in which the DNA sequence is recognized by a mixture of direct and wa

173 -determinants of poly(A) signal (PAS) on the DNA sequence is the key to understand the mechanism of t

174 While single-cell DNA sequencing is very promising for elucidating and und

175 cryption keys, and that only one technology, DNA sequencing, is required to simultaneously read the k

176 describe a kethoxal-assisted single-stranded DNA sequencing (KAS-seq) approach, based on the fast and

177 mosomal structure as well as high-throughput DNA sequencing-leading to the identification of an incre

178 Furthermore, post-mortem plasma cell-free DNA sequencing (liquid autopsy) can be a novel platform

179 nscription such as nucleosomes or particular DNA sequences may cause backtracking and transcriptional

180 performance of a plasma microbial cell-free DNA sequencing (mcfDNA-Seq) test for diagnosing pulmonar

181 We collected data on DNA sequences, messenger RNA expression levels, and pati

182 We developed a straightforward U-DNA sequencing method (U-DNA-Seq) that was combined with

183 g is an incredibly valuable third-generation DNA sequencing method due to very long read lengths, abi

184 ClvR comprises a DNA sequence-modifying enzyme such as Cas9/gRNAs that di

185 ng structural and biochemical data show that DNA sequence modulates DNA binding and remodeling by ORC

186 FXRalpha4, via direct interactions with the DNA sequence motif ER-2.

187 ed mice, which enables the identification of DNA sequence motifs driving epigenetic features.

188 confirm and expand the current catalogue of DNA sequence motifs for transcription factors, and descr

189 Origin establishment requires well-defined DNA sequence motifs in Saccharomyces cerevisiae and some

190 ntrinsic biochemical ability to scan partial DNA sequence motifs that are exposed on the surface of a

191 cis-regulatory modules that are enriched for DNA sequence motifs that resemble sequences known to be

192 ce bias when accurately identifying enriched DNA sequence motifs using score-based MEA.

193 , which overall account for nearly 580 Mb of DNA sequence not included in the reference genome assemb

194 pecific transcription factors (TFs), how the DNA sequence of cis-regulatory elements is decoded and o

195 nscription factor binding (TF) motifs in the DNA sequence of regulatory regions, enabling researchers

196 A reliable and accurate DNA sequence of the Ae. albopictus genome is essential t

197 Studying the DNA sequence of the distal 30 kb of the majority of muri

198 We propose that the repetitive DNA sequence of the PAR confers unique chromatin and hig

199 abundance of Staphylococcus were assessed by DNA sequencing of 16S ribosomal RNA, and absolute S. aur

200 ions in cancer but their quantification from DNA sequencing of bulk tumor samples is challenging.

201 riving these karyotypes from high-throughput DNA sequencing of bulk tumor samples is complicated beca

202 f whole-genome sequencing profiles from bulk DNA sequencing of cancer tissues is fueling the applicat

203 Metagenomics is the collective DNA sequencing of coexisting microbial organisms in an e

204 rity of tools for neoepitope prediction from DNA sequencing of complementary tumor and normal patient

205 DNA sequencing of HER2-mutant tumors clinically refracto

206 With the development of the high-throughput DNA sequencing of organisms at the population level, an

207 Results of whole-exome DNA sequencing of primary and metastatic tumors indicate

208 DNA sequencing of purified products yielded Phred qualit

209 endent RNA polymerases, but the influence of DNA sequence on transcription elongation properties of e

210 strong predictive performance on regulatory DNA sequences on modestly sized training sets.

211 Predicting regulatory potential from primary DNA sequences or transcription factor binding patterns i

212 re origins can be predicted, based solely on DNA sequence patterns but not on consensus motifs.

213 tions for translating digital information to DNA sequences, physically handling the biomolecules, sto

214 a variety of proteomics applications into a DNA sequencing problem.

215 e scenario, enhancer co-option, holds that a DNA sequence producing an ancestral regulatory activity

216 produced from a restriction site-associated DNA sequencing protocol for 10 species and analyzed thro

217 in conformational adjustment in the adjacent DNA sequences providing access for transcription factors

218 phenotyping with restriction site associated DNA sequencing (RAD-Seq) data from 73 freshwater lake po

219 fossil data and restriction-site associated DNA sequencing (RAD-seq) for 632 individuals representin

220 Predicting gene expression from DNA sequence remains a major goal in the field of gene r

221 Have you ever sought to use metagenomic DNA sequences reported in scientific publications?

222 In large DNA sequence repositories, archival data storage is ofte

223 DNA sequencing revealed mutations in exon 15 of the Braf

224 ed homozygosity mapping, as well as directed DNA sequencing (Sanger), we have identified nine pathoge

225 Single-cell DNA-sequencing (scDNAseq) technologies produce data that

226 ide unprecedented insight into how different DNA sequences select distinct compositions and configura

227 omic features were assessed in 368 patients (DNA sequencing set) and tumour microenvironment characte

228 dG, dC, and dA, ICL assay with variation of DNA sequences showed that the ICL reaction occurred with

229 We detect a shared G-rich DNA sequence signature that coincides with most core ori

230 The DNA sequence specificity of replication origins, mediate

231 that the Orc4 alpha-helix contributes to the DNA sequence-specificity of origins in S. cerevisiae and

232 e events, yet the vast majority of resulting DNA sequences still encoded for an N-gly site.

233 We integrate RNA-seq, DNA sequencing, TCR-seq and SNP array data across multip

234 Strand-seq is a specialized single-cell DNA sequencing technique centered around the directional

235 Recent advances in DNA sequencing techniques have made it possible to monit

236 Single-cell DNA sequencing technologies are enabling the study of mu

237 Third-generation long-read DNA sequencing technologies are increasingly used, provi

238 Recent single-cell DNA sequencing technologies enable whole-genome sequenci

239 the past decade, long-read, single-molecule DNA sequencing technologies have emerged as powerful pla

240 Recent advances in DNA sequencing technologies have enabled significant lea

241 Advances in DNA sequencing technologies have resulted in a near doub

242 The introduction of third-generation DNA sequencing technologies in recent years has allowed

243 Despite remarkable progress in DNA sequencing technologies there remains a trade-off be

244 formation both from short-read and long-read DNA sequencing technologies.

245 Despite advances in DNA sequencing technology and expanded medical guideline

246 With decreasing costs in DNA sequencing technology, rich cancer genomics datasets

247 red in the form of 'spacers' which are short DNA sequences that are captured from invaders and added

248 xponential enrichment (SELEX), we identified DNA sequences that bound to the HTH domain of Rv0890c.

249 d mutagenesis allows the generation of novel DNA sequences that can be used for a variety of importan

250 tochondria are characterized by guanine-rich DNA sequences that spontaneously form unusual three-dime

251 eplicated DNA in preparation for analysis by DNA sequencing that can be applied to any species.

252 detection (e.g. polymerase chain reaction or DNA sequencing), the detection and analysis of released

253 Therefore, the underlying DNA sequence, the promoter CpG density and, to a lesser

254 However, cGAS binds to DNA irrespective of DNA sequence, therefore, self-DNA leaked from the nucleu

255 g platform offers near real-time analysis of DNA sequence; this makes the tool attractive for deploym

256 ally influences its ability to bind specific DNA sequences through a variety of intricate mechanisms

257 and elucidate molecular pathways connecting DNA sequence to disease-associated brain dysfunction.

258 nvolves the precise manipulation of cellular DNA sequences to alter cell fates and organism traits, h

259 function of finding and invading homologous DNA sequences to enable accurate and timely DNA repair.

260 be tracked by sampling blood cells and using DNA sequencing to identify the vector integration sites.

261 e footprinting and single-molecule real-time DNA sequencing to natively and nondestructively measure

262 We also used whole-genome single-cell DNA sequencing to reveal that genetic rescue of DNA repa

263 ponentially improving cost and throughput of DNA sequencing to systematically characterize native fun

264 veral studies that have used next-generation DNA sequencing to unravel the switching process, and rev

265 dels - which predict epigenome features from DNA sequence - to support inference concerning the regul

266 o create contact domains, we inserted a 2-kb DNA sequence underlying a tissue-invariant domain bounda

267 that transcription factors bind to specific DNA sequences using a combination of base readout and sh

268 ibly analyzed as few as 100 copies of target DNA sequences using gold/silver nanostars, thus demonstr

269 lysis of CNVs containing inverted duplicated DNA sequences using nanopore sequencing identified recur

270 DNA sequencing using a prototype CsgG-CsgF protein pore

271 The amount of DNA sequence variability in a genomic region is often po

272 We identify 220 host DNA sequence variants acting in cis (MAF 0.01-49.9%) and

273 can be used to identify associations between DNA sequence variants and changes in gene expression (qu

274 How effects of DNA sequence variants are transmitted through intermedia

275 DNA sequence variants in the TBK1 gene associate with or

276 Associations between protein levels and DNA sequence variants that colocalize with risk alleles

277 rimary goal of human genetics is to identify DNA sequence variants that influence biomedical traits,

278 Million Veteran Program testing ~18 million DNA sequence variants with AAA (7642 cases and 172 172 c

279 polyploids is whether and to what extent the DNA sequence variation among homoeologous chromosomes co

280 ites and constructed networks that integrate DNA sequence variation and variation in gene expression

281 data on landscape features and mitochondrial DNA sequence variation for nine codistributed amphibian

282 tocol relies on commercial DNA synthesis and DNA sequencing via Illumina dye sequencing, and requires

283 A clear role for DNA sequence was later uncovered.

284 us sequencing reads, an additional 8.9 Mb of DNA sequence was mappable, variant calling achieved a hi

285 oximately 10 years ago, when high-throughput DNA sequencing was combined with advances in transposon-

286 Whole mitochondrial DNA sequencing was performed and mutations were determin

287 of chromatin immunoprecipitation coupled to DNA sequencing was performed.

288 Targeted DNA-sequencing was performed on 26 of 36 biopsies, and R

289 Here, using a single-cell DNA sequencing, we report the clonal architecture and mu

290 d samples was isolated, and species-specific DNA sequences were amplified and identified by the biose

291 Novel DNA sequences were discovered, whose repeat structures,

292 Cytochrome oxidase I (COI) mitochondrial DNA sequences were generated from each larval sample and

293 s that maximize the amount of N. gonorrhoeae DNA sequenced while minimizing contaminating host DNA.

294 es high sensitivities for a synthetic target DNA sequence with a unique 5-hmC in the promoter region

295 The coincidence of inverted duplicated DNA sequences with dramatically reduced sequencing accur

296 9) to near-PAMless SpRY that can target most DNA sequences with high editing efficiency and flexibili

297 nT and atpB-rbcL provided unique polymorphic DNA sequences with specific lengths for each species per

298 Single-molecule long-read DNA sequencing with biological nanopores is fast and hig

299 noprecipitation coupled with high-throughput DNA sequencing, with cells grown in the presence and abs

300 To do this, we identified a 171-bp DNA sequence within multiple paralogous copies of msp2 w