ライフサイエンスコーパス: DNA transposon

1 econd is the transposase encoded by the Pogo DNA transposon .

2 e (retroelements) or via a DNA intermediate (DNA transposons).

3 s species reside within Helitrons, a type of DNA transposon.

4 es belong to two types: retrotransposons and DNA transposons.

5 strand breaks, or the expression of MIRAGE1 DNA transposons.

6 ivatives of the piggyBac and Sleeping Beauty DNA transposons.

7 hile 5'CAG...CTG3' occurs most frequently in DNA transposons.

8 ired inverted repeats more characteristic of DNA transposons.

9 repeats, a feature common to some classes of DNA transposons.

10 6 family miRNAs were derived from the MER91C DNA transposons.

11 TE-derived siRNAs (TE-siRNAs) as opposed to DNA transposons.

12 at elements, which are a defining feature of DNA transposons.

13 ding cassette exons, nested genes and Tigger DNA transposons.

14 ralogs in a previously unidentified class of DNA transposons.

15 arry DNA fragments >10 kb is limited in most DNA transposons.

16 nsposable elements, with unusually prevalent DNA transposons.

17 Hsmar1 is a member of the mariner family of DNA transposons.

18 red to silence Tc3, but not other Tc/mariner DNA transposons.

19 Non-LTR retrotransposons represent 0.75%, DNA transposons 0.99%, whereas small RNA, simple repeats

20 We reported previously that the DNA transposon 1360 can enhance silencing of a reporter

21 t transposable elements (MITEs), remnants of DNA transposons, 4 simple sequence repeats, and low-copy

22 a) and spawned some of the largest bursts of DNA transposon activity ever recorded in any species lin

23 However, it is widely believed that DNA transposon activity has ceased in mammalian genomes

24 smissions of retroviruses and the absence of DNA transposon activity in the Old World monkey lineage.

25 Thus, these findings suggest that DNA transposon activity is a major evolutionary force in

26 integration that is afforded by this intact DNA transposon, activity that is mediated by the corresp

27 ressors are deficient in the repression of a DNA transposon and a retrotransposon-like element.

28 the integration capabilities of a eukaryotic DNA transposon and should prove useful in the treatment

29 n of two transposable elements (TEs): the T1 DNA transposon and the TCN12 retrotransposon.

30 between gene densities and the abundance of DNA transposons and a weak correlation between GR rates

31 ore often derived from retrotransposons than DNA transposons and as retrotransposon copy number in bo

32 Like bdelloid DNA transposons and Athena, these elements are found pre

33 Long Terminal Repeat retrotransposons, MuDR DNA transposons and intergenic sequences that contribute

34 2) The distribution of SCOP classes in DNA transposons and LINEs indicates that the proteins of

35 s) showing 162% increased detection, whereas DNA transposons and LINEs showed less respective technol

36 y, and highlight potential conflicts between DNA transposons and retrotransposons, major transposable

37 GRF helps improve the annotation for various DNA transposons and retrotransposons, such as miniature

38 DNA transposons and retroviruses are versatile tools in

39 Activity of selected DNA transposons and the possibly related chromosomal bre

40 s lucifugus, the only known active mammalian DNA transposon, and show that its low activity in human

41 ibution of simple repeats, retrotransposons, DNA transposons, and nucleotide substitutions, but also

42 nts, drive increases in genome size, whereas DNA transposons are associated with smaller genomes.

43 DNA transposons are defined segments of DNA that are abl

44 Strikingly, young X. tropicalis DNA transposons are derepressed and recruit p300 in hybr

45 following zygotic genome activation, whereas DNA transposons are enriched among transcripts expressed

46 xperiments to study the process by which Tn5 DNA transposons are identified and processed by their tr

47 DNA transposons are known in almost all well-studied org

48 ons and LINEs indicates that the proteins of DNA transposons are more ancient, containing folds that

49 Although DNA transposons are more efficient with large transgenes

50 rt interspersed nuclear elements (SINEs) and DNA transposons are more frequently found nearby or with

51 right ends of many naturally active mariner DNA transposons are non-identical and have different aff

52 Our study suggests that some DNA transposons are still actively shaping some mammalia

53 g terminal repeat (LTR) retrotransposons and DNA transposons are transposable elements (TEs) that per

54 Members of the piggyBac superfamily of DNA transposons are widely distributed in host genomes r

55 l genes and LTR retrotransposons, but not to DNA transposons, are dependent on the ADARs and ERI-6/7.

56 ts, one of the most diverse superfamilies of DNA transposons, are found in all eukaryotic kingdoms, b

57 contrast, LINE2 and other elements, such as DNA transposons, are more uniformly distributed in the g

58 e assessed the presence/absence of 794 human DNA transposons at orthologous positions in 10 mammalian

59 In general, the DNA transposons at the sun locus are older than the RNA

60 JMJ24 results in increased silencing of the DNA transposon AtMu1c, while overexpression of JMJ24 red

61 ctal cancer (CRC) in several Sleeping Beauty DNA transposon-based forward genetic screens in mice.

62 ceptibility gene in multiple Sleeping Beauty DNA transposon-based forward genetic screens in mice.

63 ds will increase applicability and safety of DNA transposon-based vector technologies.

64 DNA transposon-based vectors have emerged as gene vehicl

65 Bdelloids do contain numerous DNA transposons, both intact and decayed, and domesticat

66 s, except that the flanking element is not a DNA transposon but instead is long terminal repeat retro

67 tities and a high diversity of cut-and-paste DNA transposons, but no active representative of this cl

68 Mobilization of DNA transposons by transposase enzymes can cause genomic

69 report a previously uncharacterized class of DNA transposons called Polintons that populate genomes o

70 report here a superfamily of "cut and paste" DNA transposons called Transib.

71 ue of their inherent capacity to insert into DNA, transposons can be developed into powerful tools fo

72 3b and mir-427/430/302, as well as Harbinger DNA transposons carrying the Myb-like proto-oncogene hav

73 The DNA transposons constituted 13% of the D-genome compared

74 tivity in the mouse using a naturally active DNA transposon derived from the medaka fish called Tol2,

75 scribe a previously uncharacterized group of DNA transposons designated Phantom identified in the gen

76 Yet, it appears that the transfer of DNA transposons did not occur randomly as the same genom

77 cessation in the transpositional activity of DNA transposons during the later phase of the primate ra

78 This data points to intense activity of DNA transposons during the mammalian radiation and early

79 nterspersed repeats that resemble fossils of DNA transposons, elements that move by excision and rein

80 distinction to the preferences of the Hermes DNA transposon engineered to jump in yeast and the Tf1 r

81 Delivery of genetic cargo via DNA transposon engineering is a more timely and cost-eff

82 tator-like transposable elements, a class of DNA transposons, exist pervasively in both prokaryotic a

83 Here, we identified a set of DNA transposon families dubbed SPACE INVADERS (or SPIN)

84 confidently estimate that at least 40 human DNA transposon families, representing approximately 98,0

85 Here, we report the discovery of ProtoRAG, a DNA transposon family from lancelets, the most basal ext

86 elements (pble) are members of a eukaryotic DNA transposon family.

87 data to calculate the substitution rates of DNA transposons for each category and refine the age of

88 ger proteins are related to products of five DNA transposons found in fungi and nematodes, and more d

89 Mariner-like elements (MLEs) are DNA transposons found throughout the plant and animal ki

90 stead, telomere-restricted satellite DNA and DNA transposon fragments occupy its terminal ends.

91 tional approach to identify the first active DNA transposons from rice and the first active miniature

92 terility syndrome triggered by the P-element DNA transposon, germ cells harbor unexpectedly few new T

93 In particular, the Sleeping Beauty (SB) DNA transposon has advanced into clinical trials due to

94 In summary, HT of DNA transposons has contributed significantly to shaping

95 t how the distinctive biological features of DNA transposons have contributed to shape genome archite

96 DNA transposons have emerged as flexible and efficient m

97 DNA transposons have emerged as promising tools in both

98 a previously unknown category of eukaryotic DNA transposons, Helitron, which transpose by rolling-ci

99 One such element, the DNA transposon Hsmar1, entered the primate lineage appro

100 igger1 and -2, that closely resemble pogo, a DNA transposon in Drosophila, and probably were responsi

101 This is possibly caused by the presence of a DNA transposon in the PhCUL1-B promoter region, which wa

102 ole of viruses in the horizontal transfer of DNA transposons in animals.

103 taxonomic distribution of all major types of DNA transposons in eukaryotes, including Helitrons and M

104 The diverse and recent populations of DNA transposons in genus Myotis will provide an unpreced

105 ilar terminal sequences with MITEs and other DNA transposons in human and other organisms.

106 s the most widely distributed superfamily of DNA transposons in nature.

107 Thus, DNA transposons in plants appear to be regulated by chro

108 l organization, and patterns of evolution of DNA transposons in rotifers of the class Bdelloidea, a g

109 s been tremendous recent activity of various DNA transposons in the bat lineage that far exceeds thos

110 is indicates that the horizontal transfer of DNA transposons in vertebrates might be more common than

111 ing members of the Tc1 family which includes DNA transposons in vertebrates, insects, nematodes and f

112 nd Helitron elements, two distinct groups of DNA transposons, in the lineage of the vespertilionid ba

113 Here we show how short, non-autonomous DNA transposons independently generated hundreds to thou

114 the genetic variation including a Harbinger DNA transposon insertion in the upstream regulatory regi

115 ggered-cut palindromic target site model for DNA transposon insertion.

116 DNA transposons integrate into host chromosomes with lim

117 sequence divergence, allowed us to classify DNA transposons into three different categories: anthrop

118 x, to catalyse the movement of a sequence of DNA (transposon) into a target DNA.

119 on between dietary habit and the presence of DNA transposon invasions.

120 The Hermes DNA transposon is a member of the eukaryotic hAT superfa

121 The piggyBac DNA transposon is used widely in genome engineering appl

122 nsensus sequence in at least two families of DNA transposons is associated with abundant siren expres

123 The Tc1/mariner family of DNA transposons is widespread across fungal, plant and a

124 nl1 transpositions, insertions of a gigantic DNA transposon KDZ1 (~11 kb) contributed to hypermutatio

125 Nearly all DNA transposons known previously in plants were present

126 ms might be intrinsically more vulnerable to DNA transposon lateral transfer, possibly because of a w

127 How do DNA transposons live in harmony with their hosts?

128 onarily young repetitive elements, including DNA transposons, long interspersed nuclear elements and

129 In comparison with retrotransposons, DNA transposons make up a smaller proportion of most pla

130 Class 2, or DNA transposons, make up approximately 3% of the human g

131 Unlike bdelloid DNA transposons, many of which are decayed, the newly de

132 proliferating elements illustrate a general DNA transposon mechanism that can plausibly account for

133 orical contingency that may have occurred by DNA transposon-mediated insertional mutagenesis prior to

134 enorhabditis elegans and human genes against DNA-transposon-mediated disruption by excising these TEs

135 ffer animals from the deleterious effects of DNA-transposon-mediated gene perturbation.

136 y we reported that in a few rice strains the DNA transposon mPing was increasing its copy number by a

137 e elements revealed a previously unannotated DNA transposon (MuTC01) that interacts with miR2947 to p

138 we conducted an exhaustive search for human DNA transposons nested within L1 and Alu elements known

139 transposons, members of every superfamily of DNA transposons, numerous miniature elements, and novel

140 Movements of the T1 DNA transposon occurred at both temperatures with a stro

141 ave implicated the involvement of an ancient DNA transposon of the mariner family (Hsmar2) in the ini

142 parvovirus genome into a large virus-derived DNA transposon of the Polinton (polintovirus) family res

143 Cut-and-paste DNA transposons of the mariner/Tc1 family are useful too

144 Nearly all eukaryotes carry DNA transposons of the Robertson's Mutator (Mu) superfam

145 recovered, the vast majority (>85%) involve DNA transposons, of which Mariner-like and hAT-like elem

146 DNA transposons offer an efficient nonviral method of pe

147 peat transposable elements are nonautonomous DNA transposons, often inserted in introns and untransla

148 thena, in large clusters composed of diverse DNA transposons, often inserted into each other, whereas

149 east two reactions during transposition of a DNA transposon or a retroviral cDNA.

150 DNA transposons, or class 2 transposable elements, have

151 prehensive analysis of the activity of human DNA transposons over the course of primate evolution usi

152 Here, we show that the DNA transposon piggyBac can mobilize 100-kb DNA fragment

153 The DNA transposon piggyBac is widely used as a tool in mamm

154 urther found that multiple insertions of the DNA transposons, Polintons, reshuffled the eri-6/7 locus

155 Since DNA transposons preferably insert near genes, this is co

156 ons are a recently discovered group of large DNA transposons present in diverse bacterial and archaea

157 ith retrotransposons enriched in introns and DNA transposons primarily in flanking regions of genes.

158 3) DNA transposon proteins have lower contact order than ra

159 Here, we show that DNA transposons provide a recurrent supply of materials

160 Transib is a superfamily of DNA transposons recently reconstructed in silico from de

161 of prokaryotes and eukaryotes indicates that DNA transposons recognize staggered-cut palindromic targ

162 All eukaryotic DNA transposons reported so far belong to a single categ

163 DNA transposons represent the most abundant and diverse

164 nt (TE) family in S. latifolia and the first DNA transposon residing on a plant Y chromosome.

165 Galileo is a DNA transposon responsible for the generation of several

166 tive DNA families were identified, including DNA transposons, retrotransposons and simple sequence re

167 ins and evolution of CRISPR-Cas systems from DNA transposons, retrotransposons and toxin-antitoxin mo

168 Further investigation of non-LTR-RTs and DNA transposons revealed a negative correlation between

169 to the activities of mobile DNAs, including DNA transposons, RNA transposons, and endogenous retrovi

170 consisting of GC%, genes, retrotransposons, DNA transposons, simple repeats, and low complex repeats

171 ve elements (LINEs, endogenous retroviruses, DNA transposons, simple repeats, etc.) were significantl

172 ered into the genome via the Sleeping Beauty DNA transposon, suggesting that the observed methylation

173 However, the slow rate of proliferation of DNA transposons suggests that derivatives of the L1 retr

174 PIF-like elements belong to a new eukaryotic DNA transposon superfamily that is distantly related to

175 The efficiency of the DNA transposon system depends on the interaction between

176 le, using the highly efficient piggyBac (PB) DNA transposon system.

177 Sleeping Beauty is an active DNA-transposon system from vertebrates for genetic trans

178 DNA transposon systems are widely used in mammalian cell

179 genesis system as an alternative to existing DNA transposon systems.

180 , we have focused on one particular group of DNA transposons that encode a transposase with a DD(E/D)

181 Helitrons are widespread eukaryotic DNA transposons that have significantly contributed to g

182 Both resemble bacterial composite DNA transposon Tn9, consisting of a core flanked by mobi

183 Pearl is the first putative nonautonomous DNA transposon to be identified in the phylum Mollusca.

184 Tdd-4 is the first DNA transposon to be isolated from Dictyostelium discoid

185 We show that DNA transposons transfer horizontally more often than re

186 little is known about how eukaryotic mariner DNA transposons trigger this step.

187 Here, we report a novel family of DNA transposons-"tycheposons"-some of which are viral sa

188 CDS by Sal-PIF, a 3100-bp PIF/Harbinger-like DNA transposon, whereas E(2) and E(3) originated from th

189 omain insertion profiling approaches rely on DNA transposons, which are constrained by sequence bias.

190 The baobab genome is uniquely rich in DNA transposons, which make up 33%, while LTR retrotrans

191 ture with high resolution, include an active DNA transposon, widely affect functional features, and o

192 peat transposable elements (MITEs) are short DNA transposons with terminal inverted repeat (TIR) sign

193 nsposase catalyzes the mobility of P element DNA transposons within the Drosophila genome.