ライフサイエンスコーパス: DNA-binding

1 nserved DNA binding domain and disrupt MEF2C DNA binding.

2 kely due to protein instability and weakened DNA binding.

3 e conformational changes VqmA undergoes upon DNA binding.

4 e ComR sensor by triggering dimerization and DNA binding.

5 n; and the third contributes to non-specific DNA binding.

6 types and all cases of FA, is activated upon DNA binding.

7 en fast, stable folding and tight functional DNA binding.

8 -FL heterodimerization requires cofactors or DNA binding.

9 SMAD5 and the SMAD1/5/8 target inhibitor of DNA binding 1 (Id1) mRNA were also reduced in double Hfe

10 p65 subunit of NF-kappaB and attenuated the DNA binding ability of p65.

11 inhibitor mutant form of HdrR that lacks its DNA binding ability while still retaining its HdrM inter

12 binding: it forms a helix that enhances its DNA binding ability.

13 y blocks MRE11 degradation in vitro, and the DNA-binding ability of CST is required for blocking MRE1

14 Alterations of these amino acids abolish DNA-binding ability of Orc6 and result in reduced levels

15 PCH1 and PCHL also inhibit the DNA-binding ability of PIF1 to negatively regulate the e

16 al PIF4 transcription and the epidermal PIF4 DNA-binding ability.

17 , but not its transcriptional repression and DNA binding activities, were required for c-Myc upregula

18 ence of the PARP1 protein with uncompromised DNA-binding activities is required for PARPi-induced inn

19 re, we show that variant PRC1 complexes with DNA-binding activities occupy target sites independently

20 The structures and DNA-binding activities of basal NF-kappaB proteins resem

21 of Pif1 stimulated its helicase, ATPase, and DNA-binding activities, whereas maintaining its substrat

22 cer and anti-obesity drugs by inhibiting its DNA-binding activities.

23 region of these factors autoregulates their DNA binding activity.

24 ter DNA in vitro, which is dependent on LuxR DNA binding activity.

25 tive AP-1 cell line, we found that both AP-1 DNA-binding activity and BRG1 reexpression are necessary

26 (p.Arg507His and p.Arg377Trp) reduce FAN1's DNA-binding activity and its capacity to rescue mitomyci

27 protein, mRNA, and transcription factor (TF) DNA-binding activity for mouse liver tissues collected f

28 bited constitutive STAT3 phosphorylation and DNA-binding activity in human breast cancer, MDA-MB-231

29 We found that REDD1 ablation enhances Nrf2 DNA-binding activity in the retina and that the suppress

30 Our findings show that even though UAF1's DNA-binding activity is redundant with that of RAD51AP1

31 However, whereas the DNA-binding activity of RAD51AP1 has been shown to be im

32 lock imparted by Tbf1 can be overcome by the DNA-binding activity of the single-stranded DNA-binding

33 This biochemical analysis revealed that the DNA-binding activity of UAF1 is indispensable for enhanc

34 ParA also has a site-specific DNA-binding activity to the par operator (parOP), which

35 -gamma target genes and increased PPAR-gamma DNA-binding activity.

36 sociation with Rb and without decreasing its DNA-binding activity.

37 only the EBD, the evolved biosensors display DNA-binding affinities similar to BenM, and are function

38 er (YoeB-YefM2-YefM2-YoeB) with low and high DNA-binding affinities, respectively.

39 ited epigenetic states, transcription factor-DNA binding affinity thresholds and influences of given

40 etion of the C-tail greatly increases Mtf1's DNA binding affinity.

41 assumed that decreasing transcription factor DNA-binding affinity reduces transcription initiation by

42 ential contributions to RNA-binding, but not DNA-binding, affinity.

43 eals the overall architecture of CST and the DNA-binding anchor site.

44 istically, the presence of 6mA could repress DNA binding and bending by mitochondrial transcription f

45 egion can be truncated while preserving both DNA binding and cellular activity.

46 inus of cI(VP882), inhibiting both cI(VP882) DNA binding and cI(VP882) autoproteolysis.

47 inR multimerization, resulting in diminished DNA binding and concomitant decreased repressor activity

48 ation sites alter GLK1 protein stability and DNA binding and impair plant responses to BRs/darkness.

49 f S180A knock-in cells demonstrated enhanced DNA binding and increased target gene expression.

50 rapy drug treatment, NSC194598 inhibited p53 DNA binding and induction of target genes.

51 interacting with Ascl1, interfering with its DNA binding and limiting neurogenesis within LGE progeni

52 agreement with previous biochemical data on DNA binding and mostly fit known complex structures.

53 to measure distance changes associated with DNA binding and prechemistry fingers movement of human P

54 requires accurate prediction of regulators' DNA binding and precise determination of biologically si

55 emical data show that DNA sequence modulates DNA binding and remodeling by ORC, and that DNA bending

56 We discovered that both Cic-DNA binding and repression are rapidly reinstated in the

57 ed mutant UAF1 variants that are impaired in DNA binding and tested them together with RAD51AP1 in RA

58 egion of FOXN1 is required for high-affinity DNA binding and that FOXN1 has a significantly reduced a

59 r heterodimerization of TFs are required for DNA binding and the association interface between subuni

60 ngers 11-13 are necessary and sufficient for DNA binding and, in combination with the N terminal regi

61 We found that DNA-binding and microtubule-binding proteins can diffuse

62 Thus, although both DNA-binding and microtubule-binding proteins can diffuse

63 We studied Hox TF DNA-binding and regulatory activity during an in vitro m

64 Missense mutations in cancers in the p53 DNA-binding and tetramerization domains cement the impor

65 way instrumentally enables nuclear NF-kappaB DNA-binding and thereby pro-inflammatory responses in mo

66 F-kappaB transcriptional complex to decrease DNA-binding and transcriptional activity.

67 including Wnt signaling, ribosome function, DNA binding, and clustered protocadherins.

68 air and liquids to visualize ring assembly, DNA binding, and unwinding activity of individual Twinkl

69 ription factor MftR that leads to attenuated DNA binding, and we show using chromatin immunoprecipita

70 In vitro DNA-binding assay showed that TRIM28 knockdown increased

71 In vitro DNA binding assays and crystallographic studies reveal t

72 we demonstrate that high-throughput in vitro DNA binding assays coupled with unbiased computational a

73 re-based mutations, in vitro deamination and DNA binding assays, and HIV-1 restriction assays identif

74 helix-loop-helix (bHLH) domain of Ascl1, and DNA-binding assays demonstrated that this interaction in

75 The R882H mutation reduces the DNA binding at the homodimeric interface, as well as the

76 s on the origin recognition complex (ORC), a DNA-binding ATPase that loads the Mcm2-7 replicative hel

77 ded DNA-binding protein (SSBP) cofactors and DNA-binding basic helix-loop-helix (bHLH) and GATA trans

78 1 transcription factor, the dimerization and DNA binding behavior of retinoic acid receptor (RAR) and

79 of the PPARgamma cistrome represents direct DNA binding; both half sites can be extended upstream, a

80 ase domain (SRAPd), a function that requires DNA binding but is independent of its autopeptidase and

81 ariants of the p53 not only suffer a loss in DNA binding, but they also show distinct structural stab

82 the allosteric mechanism of nickel-activated DNA binding by HpNikR is driven by conformational select

83 NSC194598 selectively inhibited DNA binding by p53 and homologs p63/p73, but did not aff

84 The results suggest DNA binding by p53 can be targeted using small molecules

85 PRC2 dimerization enhances CGI DNA binding by PCLs in pairs in vitro, reminiscent of th

86 ring and HR-mediated DNA repair, the role of DNA binding by UAF1 in these processes is unclear.

87 reside on STF and not MTF motifs, perturbing DNA binding by various STFs (BMP/TGF-beta-directed SMADs

88 we show that Thr55 phosphorylation inhibits DNA-binding by enhancing competitive interactions betwee

89 KZFP divergence and concomitant evolution of DNA binding capabilities are mechanistically linked to m

90 (ATR) at Ser101 and Ser241 to attenuate its DNA binding capacity.

91 Upon DNA binding, cGAS becomes enzymatically active to genera

92 ha and elucidates the mechanism by which the DNA binding cleft is opened during transcription initiat

93 uid phase separation to compartmentalize its DNA-binding cofactor TEAD4, coactivators BRD4 and MED1,

94 TEN1) proteins, which form a single-stranded DNA-binding complex, localize at stalled forks and prote

95 The potent DNA-binding compound triaminotriazine-acridine conjugate

96 This high affinity DNA binding contrasts reports made for isolated protein

97 he p53 core DNA-binding domain regulates the DNA binding cooperativity and transcriptional activity o

98 (e.g., phosphorylation and acetylation) and DNA binding cooperativity of p53.

99 DNA binding correlates with nucleotide occupancy: five M

100 In cells, DNA-binding deficiency of UAF1 increased DNA damage sens

101 srupt the DNA-binding function of MEF2C, and DNA binding-deficient Mef2c global heterozygous mice dis

102 Notably, the expression of the DNA-binding-deficient mutant of NuMA affects chromatin d

103 Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate ch

104 missense mutations cluster in the conserved DNA binding domain and disrupt MEF2C DNA binding.

105 damage through a mechanism dependent on its DNA binding domain and, at least in part, on poly-ADP ri

106 n amino-terminal region of Zta and the basic DNA binding domain of Zta in regulating Zta ubiquitinati

107 Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduce

108 l in-frame initiation codons upstream of the DNA binding domain.

109 Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cance

110 the disordered AD2 motif and the structured DNA-binding domain (DBD).

111 ind that missense changes within or near the DNA-binding domain (p.Arg507His and p.Arg377Trp) reduce

112 However, a second contact between the XPA DNA-binding domain (XPA DBD) and the RPA70AB tandem ssDN

113 The Cys2His2 zinc finger is the most common DNA-binding domain expanding in metazoans since the fung

114 t that Hmx3a may not require its homeodomain DNA-binding domain for its roles in viability or embryon

115 scription factors that contain a homeodomain DNA-binding domain have crucial functions in most aspect

116 This rigid arrangement of the putative DNA-binding domain imposed strong constraints on how Ter

117 e lncRNAs with high affinity through its HMG DNA-binding domain in vitro.

118 Here, we report a crystal structure of the DNA-binding domain of a model ASO-binding protein PC4, i

119 ns that associate with the dimerization- and DNA-binding domain of ATF4 (the bZIP domain) in mouse sk

120 Here, we have characterized the DNA-binding domain of human FoxP1 by integrating single-

121 We also identified a distinct DNA-binding domain of human Orc6, named as HsOrc6-DBD.

122 int, which requires its interaction with the DNA-binding domain of PARP1.

123 leukemia fusion protein, which contains the DNA-binding domain of Runt-related transcription factor

124 eta) knockout mouse, created by removing the DNA-binding domain of the ERbeta gene or interruption of

125 f conserved phosphorylation sites within the DNA-binding domain of the receptor.

126 narrow or broad target specificity, and the DNA-binding domain of the transcription activator-like e

127 haracterized phosphorylation in the p53 core DNA-binding domain regulates the DNA binding cooperativi

128 central and posterior groups based on their DNA-binding domain similarity.

129 C-terminal region a previously unappreciated DNA-binding domain that exhibits specific binding to G-q

130 the MADS (MCM1, Agamous, Deficiens, and Srf DNA-binding domain)-box transcriptional co-regulator, Mk

131 ee arsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site.

132 Mutations in p53 protein, especially in the DNA-binding domain, is one of the major hallmarks of can

133 dence for transcription factor tethering and DNA-binding domain-independent action.

134 ntaining a non-sense mutation within the AP2 DNA-binding domain.

135 Another motif, DPHK, is in the DNA-binding domain.

136 cally affects the conformation of N-terminal DNA-binding domain.

137 0, adjacent to the wing2 region of the FOXA1 DNA-binding domain.

138 esidues (human S183/S185, mouse S180) in the DNA-binding domain.

139 s structurally unrelated to the E. coli McrB DNA-binding domain.

140 ora-B-dependent phosphorylation of the SAF-A DNA-binding domain; failure to execute this pathway lead

141 n cooperativity between the ligand (LBD) and DNA binding domains (DBD) of AR, and its autoinhibition

142 gulatory expression that depends on the Xrp1 DNA binding domains and is necessary for cell competitio

143 found that three fru isoforms with different DNA binding domains show a division of labor on male agg

144 method is highly specific for the mapping of DNA binding domains.

145 t cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX1

146 DNA polymerase beta has two DNA-binding domains that interact with the opposite side

147 than PPM models for 314 tested TFs (or their DNA-binding domains) from four families (bHLH, bZIP, ETS

148 localization patterns, often lack classical DNA-binding domains, presenting challenges in identifyin

149 While the two McrBC complexes use different DNA-binding domains, these contribute to the same genera

150 proteins as well as small proteins fused to DNA-binding domains.

151 posterior group paralogs that share similar DNA-binding domains.

152 hich could distinguish between IRF8 and IRF4 DNA-binding domains.

153 l domain-swapped dimers formed through their DNA-binding domains.

154 ent states and decreases the mobility of the DNA-binding domains.

155 UAF1 and RAD51AP1 have coordinated roles in DNA binding during HR and DNA damage repair.

156 Furthermore, XPG DNA binding elements conserved with FEN1 superfamily mem

157 ure, we suggest that p44/p62 acts as a novel DNA-binding entity that enhances damage recognition in T

158 In vitro DNA-binding experiments and structural prediction show t

159 ricts HO activation to one of two paralogous DNA-binding factors.

160 s found in individuals with MCHS disrupt the DNA-binding function of MEF2C, and DNA binding-deficient

161 SC194598 that inhibits p53 sequence-specific DNA binding in vitro (IC(50) = 180 nM) and in vivo.

162 , enhanced phosphorylation (Ser73), and AP-1/DNA-binding in response to S. mansoni infection.

163 in which the clamp first opens, followed by DNA binding, inducing opening of the loader to release a

164 ther existing networks inferred by different DNA binding information-based methods.

165 Cooperative DNA binding is a key feature of transcriptional regulati

166 of the initial strand transfer and show how DNA binding is modulated by the asymmetric transposase t

167 anismal level that the cooperative nature of DNA binding is reduced by phosphorylation of highly cons

168 Zinc, which does not promote high-affinity DNA binding, is unable to induce the same allosteric res

169 ommissions chromatin accessibility and Smad3 DNA binding leading to a transcriptional program of RhoG

170 uence selectivity is a critical attribute of DNA-binding ligands and underlines the need for detailed

171 in complex with the GCC box, as well as the DNA binding mechanisms of the N-terminal alpha-helix and

172 pigenetic mark as the primary determinant of DNA binding, MeCP2 is also reported to have an affinity

173 d crystallographic studies reveal the ZNF410-DNA binding mode.

174 down-regulated by ethylene in shoots, and a DNA binding motif was identified that is important for t

175 vely charged cleft and a helix-hairpin-helix DNA-binding motif found in other DNA repair enzymes.

176 ct Foxp3 targets depended on the presence of DNA binding motifs for other TFs, including TCF1.

177 ant FrtR protein was purified, and conserved DNA binding motifs were determined using electrophoretic

178 in DNA sequences containing their respective DNA-binding motifs and identify preferential motif arran

179 ely through suramin binding to the "AT-hook" DNA-binding motifs and therefore preventing HMGA2 from b

180 The similar DNA-binding motifs of the various HOX TFs contrast with

181 HMGA1 proteins also carry multiple "AT-hook" DNA-binding motifs, suramin is expected to inhibit HMGA1

182 s in the binding of suramin to the "AT-hook" DNA-binding motifs.

183 ma/delta'-covariant residue pairs within the DNA binding N-termini of helices alpha2 and alpha3; and

184 criptional changes a cell undergoes upon the DNA binding of a POI.

185 into the main factors driving collaborative DNA binding of MEF2A and into its role in B cell-specifi

186 criptomic difference was not correlated with DNA binding of NF-Y but with splicing of NF-YA.

187 Agents targeting their respective DNA binding or downstream chromatin-remodeling events ha

188 Genome-wide analysis demonstrated similar DNA-binding patterns of HOXA1 and Labial in mouse cells,

189 -based models to investigate the folding and DNA-binding processes of the multidomain Y-family DNA po

190 RAD52 oligomeric conformation, modulates its DNA binding properties, stimulates SSA activity and prom

191 sequently suggests that the knowledge of the DNA-binding properties of the proteins is in itself not

192 orial complexity of FAC formation, and their DNA-binding properties.

193 Analysis involved assessing 43 kDa Tar-DNA binding protein (TDP-43) accumulation in brain regio

194 nduced down-regulation of immune regulator Z-DNA binding protein 1.

195 port that the XPE gene product DDB2 (damaged DNA binding protein 2), a nucleotide excision repair pro

196 Another protein, TAR DNA binding protein 43 (TDP-43) has been identified in u

197 asmic mislocalization and aggregation of TAR-DNA binding protein 43 (TDP-43) is found in the majority

198 ing protein gene CHD7 (Chromodomain helicase DNA binding protein 7).

199 While TDP-43 is an essential RNA/DNA binding protein critical for RNA-related metabolism,

200 Single-strand DNA binding protein did not affect PcrA translocation ve

201 We show that the phosphorylation of the RNA-DNA binding protein fused in sarcoma (FUS) is higher in

202 alleviated by binding of the single-stranded DNA binding protein, RPA, to the excluded DNA strand.

203 ic mutations in the TARDBP gene encoding TAR DNA binding protein-43 (TDP-43) have been identified in

204 of EBNA1, a viral encoded sequence-specific DNA binding protein.

205 Single-stranded DNA-binding protein (SSB) is typically present at the ab

206 of LMO2 and LDB1 as well as single-stranded DNA-binding protein (SSBP) cofactors and DNA-binding bas

207 , expressing ALS-linked gene mutants for TAR DNA-binding protein (TDP-43) and superoxide dismutase 1

208 Z-DNA-binding protein 1 (ZBP1) is an innate immune sensor

209 Z-DNA-binding protein 1 (ZBP1; also known as DAI or DLM-1)

210 usions of pathogenic deposits containing TAR DNA-binding protein 43 (TDP-43) are evident in the brain

211 TAR DNA-binding protein 43 (TDP-43) has emerged as a key pla

212 lpha-synuclein in Parkinson disease, and TAR DNA-binding protein 43 in amyotrophic lateral sclerosis.

213 interaction with the RNA-binding protein TAR DNA-binding protein 43 kDa (TDP-43).

214 TDP-43 (TAR DNA-binding protein 43) and FUS (fused in sarcoma) are a

215 for the protein CHD8 [chromodomain-helicase-DNA-binding protein 8]) are among the most common mutati

216 sults demonstrate that YaaA is a new type of DNA-binding protein associated with the oxidative stress

217 oteins that associate with the chromatin and DNA-binding protein Barrier-to-autointegration factor (B

218 dition of mitochondrial single-stranded (ss) DNA-binding protein both influences the ways Twinkle loa

219 This sequence-specific DNA-binding protein can disrupt EBV latency by driving t

220 to the nucleus, where it associates with the DNA-binding protein LAG-1/CSL to activate target gene tr

221 Insoluble, hyperubiquitylated TAR DNA-binding protein of 43 kDa (TDP-43) in the central ne

222 A DNA-binding protein ParB nucleates on parS sites and mus

223 An antibody specific to G4-DNA and the G4-DNA-binding protein PC4 bind to the Atg7 PQFS.

224 a-helical protein; and LUX ARRYTHMO (LUX), a DNA-binding protein required to recruit the evening comp

225 DNA-binding activity of the single-stranded DNA-binding protein RPA, efficient DNA replication throu

226 RADX is a mammalian single-stranded DNA-binding protein that stabilizes telomeres and stalle

227 6.5- angstrom structure of BurrH, an 82-kDa DNA-binding protein whose helical pseudosymmetry prevent

228 ng factor (CTCF) has been characterized as a DNA-binding protein with important functions in maintain

229 changes in the mitochondrial single-stranded DNA-binding protein, a crucial protein involved in mtDNA

230 gregated proteins, the most common being TAR DNA-binding protein-43 (TDP-43), tau, and fused in sarco

231 DNA binding proteins rapidly locate their specific DNA t

232 , we discovered that cohesin SA1 and SA2 are DNA binding proteins.

233 gests they do not block 1D searches by other DNA binding proteins.

234 Although the fast association between DNA-binding proteins (DBPs) and DNA is explained by a fa

235 Our approach should be adaptable to other DNA-binding proteins as well as small proteins fused to

236 On the protein side, only DNA-binding proteins can perform rotation-coupled diffus

237 Many DNA-binding proteins induce changes in the structure of

238 ns enables them to diffuse more quickly than DNA-binding proteins on both biopolymers.

239 Rsc1/2 isoforms both cooperate with the DNA-binding proteins Rsc3/30 and the HMG protein, Hmo1,

240 Transcription factors are DNA-binding proteins that have key roles in gene regulat

241 nucleosomes can influence, or be altered by, DNA-binding proteins, single-molecule techniques are inc

242 These functions are mediated by DNA-binding proteins, such as Cdc13 in Saccharomyces cer

243 er of the Ribbon-Helix-Helix (RHH) family of DNA-binding proteins, to transfer of DNA and protein sub

244 rules are developed to insert operators for DNA-binding proteins.

245 interactions between regulatory elements and DNA-binding proteins.

246 been experimentally assayed for thousands of DNA-binding proteins.

247 target DNA by adjacently bound programmable DNA-binding proteins.

248 inding residue predictions appeared best for DNA-binding (Q2 = 81 +/- 0.9%) followed by RNA-binding (

249 imer interactions and presumably distort the DNA-binding region.

250 at small changes outside of highly conserved DNA-binding regions can lead to profound changes in prot

251 gnition, some fundamental aspects of protein-DNA binding remain poorly understood(1,2).

252 Mutations in the methyl-DNA-binding repressor protein MeCP2 cause the devastatin

253 ange, p.(Ala273Lys), is predicted to alter a DNA-binding residue in the first of three zinc fingers.

254 DNA-binding results and cellular activity confirm that O

255 A second orthogonal DNA binding site identified in the mEndoG structure acco

256 al that Orc1 and Orc4 constitute the primary DNA binding site in the ORC ring and cooperate with the

257 ver, exhibit functional binding when the ZIC DNA binding site is embedded in a multiple transcription

258 unknown function, one SNP is located in the DNA binding site of a member of the Plasmodium ApiAP2 tr

259 ed that Gsx2 mediates opposing outcomes in a DNA binding site-dependent manner: Monomer Gsx2 binding

260 MORC4 and mutagenesis studies show that the DNA-binding site and the histone/ATPase binding site of

261 ection strategy, we determined the preferred DNA-binding site for CDA-KLF1.

262 ormed by histones H2A and H2B via its second DNA-binding site(19).

263 oconductor by analyzing transcription factor DNA binding sites and transcriptional regulatory network

264 DNA binding sites for the transcription factors are clos

265 nduce chromatin opening by recognizing their DNA binding sites on nucleosomes.

266 The YY1 responsive element mapped not to YY1 DNA-binding sites in the HTLV-1 LTR but to the R region.

267 ing the transposon end and the generation of DNA-binding sites.

268 ng experiments have measured escape times of DNA-binding species diffusing in living cells: CRISPR-Ca

269 red directly, using as the primary probe the DNA-binding species with the binding site inactivated an

270 enomenological description of diffusion of a DNA-binding species, useful in larger-scale modeling of

271 Here we introduce a framework for inferring DNA-binding specificities by considering protein-DNA int

272 In order to infer DNA-binding specificities from these data, numerous soph

273 werful means to enable accurate inference of DNA-binding specificities.

274 mouse and fly Gsx factors unexpectedly gain DNA binding specificity by forming cooperative homodimer

275 Likewise, models of its DNA binding specificity remain error prone due to a lack

276 n vitro assays to systematically measure the DNA-binding specificity (Spec-seq), catalytic activity s

277 This model enabled confirmation of altered DNA-binding specificity for FOXL2(C134W) and identificat

278 12a (Cpf1) appears to be primarily driven by DNA-binding specificity.

279 Quantitative DNA binding studies with fluorescence anisotropy-based t

280 ys)) using surface plasmon resonance protein-DNA binding studies.

281 Here, we report ARID1A, a DNA-binding subunit of the SWI/SNF epigenetic complex, c

282 zyme DpdA provides insight into its probable DNA binding surface and general mode of DNA recognition.

283 to structural reorientation of the putative DNA-binding surface and extends the substrate-binding po

284 driven by favorable interactions between the DNA-binding surface of the DBD and the multiple phosphor

285 The large DNA-binding surface on FACT appears to be protected by t

286 various DNA motifs are mediated by its flat DNA-binding surface, which is centered on a short loop s

287 e binding to the same consensus motif, their DNA-binding syntax is different, suggesting discriminato

288 Upon ASFV DNA binding, the Cas12a/crRNA/ASFV DNA complex becomes a

289 r of target genes, acting as coactivators of DNA-binding transcription factors or as negative regulat

290 of transcriptional regulation is mediated by DNA-binding transcription factors that bind to regulator

291 The Mediator complex directs signals from DNA-binding transcription factors to RNA polymerase II (

292 ading requires a closed DNA substrate, and a DNA-binding transcriptional regulator can act as a roadb

293 mechanisms underlying, transcription factor DNA binding variation is therefore key to elucidate the

294 rease requires both the protease Lon and the DNA-binding virulence regulator PhoP.

295 f 514 of 1667 GAS genes (31%) whereas direct DNA binding was identified for 105 GAS genes.

296 r (b)HLH protein, KIDARI (KDR), which is non-DNA-binding, was identified in de-etiolation studies and

297 stic understanding of target recognition and DNA binding when applied to other CRISPR-Cas systems.

298 aled thermodynamic factors affecting dCas12a DNA binding, which should guide the design and optimizat

299 s the redox status in bacteria by modulating DNA binding, while its cluster cycles between +1 and +2

300 riation of TdDof, a gene encoding a putative DNA binding with one finger protein, controls the stem s

301 molecule in the highly conserved C-terminal DNA-binding zinc finger domains.