ライフサイエンスコーパス: DNA-binding domain

1 3P) predicted to affect the highly conserved DNA binding domain.

2 denosine (G > A) mutation in the mouse MeCP2 DNA binding domain.

3 is at a highly conserved residue within the DNA binding domain.

4 y a central conserved region overlapping the DNA binding domain.

5 hich differs by a single arginine within the DNA binding domain.

6 the C-terminus, i.e. juxtaposed to the VirG DNA binding domain.

7 ting gene expression through their conserved DNA binding domain.

8 tivity but requires residues in the receptor DNA binding domain.

9 l in-frame initiation codons upstream of the DNA binding domain.

10 a protein methylase with a sequence-specific DNA binding domain.

11 olytic activities and contains a unique GT-1 DNA binding domain.

12 ctly phosphorylates YY1 at serine 365 in the DNA-binding domain.

13 e domains: an R domain, an AAA+ domain and a DNA-binding domain.

14 KstR show variability in the position of the DNA-binding domain.

15 ntaining a non-sense mutation within the AP2 DNA-binding domain.

16 n was recognized as a new class of conserved DNA-binding domain.

17 homodimer as both a monomer and dimer of the DNA-binding domain.

18 erential activation to the heterologous GAL4 DNA-binding domain.

19 is an atypical nuclear receptor that lacks a DNA-binding domain.

20 Another motif, DPHK, is in the DNA-binding domain.

21 cally affects the conformation of N-terminal DNA-binding domain.

22 0, adjacent to the wing2 region of the FOXA1 DNA-binding domain.

23 esidues (human S183/S185, mouse S180) in the DNA-binding domain.

24 nsferase domain and a C-terminal nonspecific DNA-binding domain.

25 s structurally unrelated to the E. coli McrB DNA-binding domain.

26 identified a putative helix-turn-helix (HTH) DNA-binding domain.

27 this may be due to increased dynamics of the DNA-binding domain.

28 gnition sequence, one in each of its two AP2 DNA binding domains.

29 predictions and the addition of non-specific DNA binding domains.

30 he N-terminal oligomerization and C-terminal DNA binding domains.

31 n at least three RPA-encoded single-stranded DNA binding domains.

32 fectors (TALEs) contain modular programmable DNA binding domains.

33 method is highly specific for the mapping of DNA binding domains.

34 proteins as well as small proteins fused to DNA-binding domains.

35 posterior group paralogs that share similar DNA-binding domains.

36 hich could distinguish between IRF8 and IRF4 DNA-binding domains.

37 cooperativity between the UHRF1 histone- and DNA-binding domains.

38 rited from the structural analogies of their DNA-binding domains.

39 and dynamics of site discrimination by their DNA-binding domains.

40 -ZFs) comprise the largest class of metazoan DNA-binding domains.

41 l domain-swapped dimers formed through their DNA-binding domains.

42 ent states and decreases the mobility of the DNA-binding domains.

43 that reflect the binding preferences of the DNA-binding domains.

44 es, as we show that acetylation of an ApiAP2 DNA-binding domain ablates its DNA-binding propensity.

45 ppear to be insulated, with mutations in the DNA binding domain altering only the DNA affinity and th

46 rectly, mainly through its beta-strand rich, DNA-binding domain (AML-(1-175)), with the assistance of

47 peronin TRiC (or CCT), primarily through its DNA binding domain (AML1-175).

48 re that a folding intermediate of AML1-ETO's DNA-binding domain (AML1-175) forms a stable complex wit

49 missense mutations cluster in the conserved DNA binding domain and disrupt MEF2C DNA binding.

50 at NONO directly interacts with TET1 via its DNA binding domain and recruits TET1 to genomic loci to

51 s system, named split-TALE (sTALE), the TALE DNA binding domain and the transcription activation doma

52 damage through a mechanism dependent on its DNA binding domain and, at least in part, on poly-ADP ri

53 ription factor families contain very similar DNA binding domains and hence have the potential to bind

54 gulatory expression that depends on the Xrp1 DNA binding domains and is necessary for cell competitio

55 no acid subunits, folding into an N-terminal DNA-binding domain and a C-terminal dimerization domain.

56 protein, called Omomyc, consists of the Myc DNA-binding domain and a coiled-coil region to facilitat

57 ealed a bipartite structure with a separable DNA-binding domain and a non-specific cleavage domain).

58 ce-dependent effects do not rely on the Chd1 DNA-binding domain and are not due to differences in nuc

59 ces conformational changes in RAG-1 within a DNA-binding domain and in the ZnH2 domain, which acts as

60 Members of this family lack a DNA-binding domain and interact with TGACG-motif binding

61 rototype foamy virus featuring an additional DNA-binding domain and longer interdomain linkers, the a

62 ational changes link the C terminus with the DNA-binding domain and provide a biophysical rationale f

63 n regulators with a well-defined zinc finger DNA-binding domain and there is evidence that they elici

64 zation helices in the C-terminal domain, the DNA-binding domains and a consensus DNA-binding site of

65 obabilistic framework that not only exploits DNA-binding domains and specificities, but also integrat

66 with all isoforms sharing the same HDAC and DNA-binding domains and the long isoforms containing a u

67 nges the relative spatial disposition of the DNA-binding domains and thereby disrupt the protein-DNA

68 ered within the portion of REST encoding the DNA-binding domain, and functional analyses showed that

69 ffects a distinct structural feature of this DNA-binding domain, and functional assays demonstrate th

70 found a new allele of hsf-1 that alters its DNA-binding domain, and we found three additional allele

71 apicomplexa-specific proteins containing AP2 DNA-binding domains (ApiAP2s) was identified in malaria

72 rators, ORE1, ORX1, ORA1, and ORR3, the AraR-DNA binding domain (AraR-DBD) as well as full-length Ara

73 in adopting a dumbbell architecture in which DNA binding domains are connected by long coiled-coils.

74 presented here revealed that the Rgg protein DNA-binding domains are covalently linked across their d

75 We demonstrated that, even though their DNA-binding domains are extremely similar, WelLFY and it

76 mmunications between the tetramerization and DNA-binding domains are noted.

77 s AldR (Rv2779c) showing that the N-terminal DNA-binding domains are swapped, forming a dimer, and fo

78 e effect of Foxo1 phosphorylation within its DNA-binding domain at serine 209 by Mst1 kinase is not f

79 e present co-crystal structures of the FoxN3 DNA binding domain bound to the FKH and FHL sites, respe

80 , we solved the structure of the human LRH-1 DNA-binding domain bound to the same element.

81 the MADS (MCM1, Agamous, Deficiens, and Srf DNA-binding domain)-box transcriptional co-regulator, Mk

82 isoform, TEAD4-S, which lacks an N-terminal DNA-binding domain, but maintains YAP interaction domain

83 th an ETS domain, such as ETV6, whose single DNA-binding domain cannot contact both source and destin

84 Hence, although lacking the presumed DNA binding domain, CHT7 modulates the expression of cel

85 nificantly reduces aggregation of the WT p53 DNA-binding domain, confirming the higher aggregation te

86 In the apo state, the DNA-binding domain contacts the edge of the nucleosome w

87 f is a gene for a ubiquitously expressed Ets DNA-binding domain-containing transcriptional repressor.

88 This function is executed by the C-terminal DNA binding domain (CTD) which binds single-stranded (ss

89 Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate ch

90 The DNA binding domain (DBD) of the tumor suppressor p53 is

91 was created by interrupting the gene at the DNA binding domain (DBD) with a neocassette.

92 ity, ability to restore zinc to purified p53 DNA binding domain (DBD), and ability to restore site-sp

93 , which contains a proline-rich region and a DNA binding domain (DBD), is auto-cleaved from the ER me

94 ectly interacting with the sequence-specific DNA binding domain (DBD).

95 n cooperativity between the ligand (LBD) and DNA binding domains (DBD) of AR, and its autoinhibition

96 ntuitively, high-affinity DNA binding of RPA DNA-binding domain (DBD) A and DBD-B near the fork junct

97 lved the X-ray crystal structure of an EBNA1 DNA-binding domain (DBD) and discovered a novel hexameri

98 homology 2 domain (SH2), linker domain (LD), DNA-binding domain (DBD) and the coiled-coil domain.

99 f this protein; a number of mutations in the DNA-binding domain (DBD) are associated with XP disease.

100 The RARbeta ligand-binding domain (LBD) and DNA-binding domain (DBD) are physically connected to fos

101 alpha (RXRalpha), and phosphorylation of the DNA-binding domain (DBD) at Thr-38 in CAR regulates this

102 ture at 1.6- angstrom resolution of the Pho7 DNA-binding domain (DBD) bound at its target site 2 in t

103 of three functional domains: the N-terminal DNA-binding domain (DBD) containing three zinc fingers,

104 Missense mutations in the p53 DNA-binding domain (DBD) contribute to half of new cance

105 ution (P152L) in TP53 at the very end of its DNA-binding domain (DBD) in a sample from an Indian oral

106 eport the crystal structure of the KSHV LANA DNA-binding domain (DBD) in complex with its high-affini

107 Here, based on the analysis of BRCA2 DNA-binding domain (DBD) mutants (c.8488-1G>A and c.8524

108 property of the glucocorticoid receptor (GR) DNA-binding domain (DBD) not shared by other members of

109 rofiles reveal that the direct fusion of the DNA-binding domain (DBD) of Fkh1 to Dbf4 restores the Fk

110 molecules that physically interact with the DNA-binding domain (DBD) of FOXO3 and modulate the FOXO3

111 we determined two crystal structures of the DNA-binding domain (DBD) of human FOXC2 protein, in comp

112 Targeting the DNA-binding domain (DBD) of STAT3, however, has been avo

113 ich motifs located both in the AD and in the DNA-binding domain (DBD) of the related ETS factor ETV4

114 or (GR) binds the noncoding RNA Gas5 via its DNA-binding domain (DBD) with functional implications in

115 This anchor connects the DNA-binding domain (DBD) with the ligand-binding domain

116 -canonical interaction with ER-alpha via its DNA-binding domain (DBD).

117 the disordered AD2 motif and the structured DNA-binding domain (DBD).

118 rine-rich region N-terminal to the conserved DNA-binding domain (DBD).

119 In our proposed mechanism, DNA-binding-domains (DBD) of R insert in major grooves o

120 updated the structural annotation of the TF DNA binding domains (DBDs) following a published hierarc

121 te cell-fate changes, using diverse types of DNA binding domains (DBDs).

122 s) operate by the combined activity of their DNA-binding domains (DBDs) and effector domains (EDs) en

123 Six DNA-binding domains (DBDs) in RPA promote high-affinity

124 ivo Despite structural similarities in their DNA-binding domains (DBDs), LANA homologs from Kaposi sa

125 we report the crystal structure of two EBNA1 DNA-binding domain dimers bound to a DS half-site.

126 ee arsenic-coordinating cysteines within the DNA-binding domain, distal to the zinc-binding site.

127 led a 5-amino acid segment at the end of the DNA-binding domain essential for the development of TECs

128 lustered within the regions of TP53 encoding DNA-binding domains, essential for DNA contact and struc

129 chanisms that underlie the diversity of this DNA-binding domain exclusively in metazoans are, however

130 s demonstrated that missense variants in the DNA-binding domain exert a dominant-negative effect (DNE

131 The Cys2His2 zinc finger is the most common DNA-binding domain expanding in metazoans since the fung

132 ora-B-dependent phosphorylation of the SAF-A DNA-binding domain; failure to execute this pathway lead

133 Devoid of a DNA-binding domain, FHL2 is a transcriptional cofactor t

134 t that Hmx3a may not require its homeodomain DNA-binding domain for its roles in viability or embryon

135 The homeobox encodes a DNA-binding domain found in transcription factors regula

136 IHSF115 bound to an isolated HSF1 DNA-binding domain fragment.

137 results demonstrate the possibility of using DNA binding domains from bacterial response regulators a

138 than PPM models for 314 tested TFs (or their DNA-binding domains) from four families (bHLH, bZIP, ETS

139 reports on the ability of Rap1-heterologous DNA-binding domain fusion proteins to serve as chimeric

140 artificially targeting Fob1 or Sir2 as Gal4 DNA binding domain fusions.

141 that a single amino acid substitution in the DNA-binding domain gave rise to the domestication of 'Mi

142 2(nd) helix of the GTL1 N-terminal trihelix DNA-binding domain (GTL1N) destabilizes a hydrophobic co

143 Mouse Klf4 DNA binding domain has roughly equal affinity for methyl

144 scription factors that contain a homeodomain DNA-binding domain have crucial functions in most aspect

145 Distinct folds associated with predicted DNA-binding domains (HTH1 and HTH2) and phosphoenolpyruv

146 This rigid arrangement of the putative DNA-binding domain imposed strong constraints on how Ter

147 structure of the functionally essential ICP4 DNA binding domain in complex with a segment from its ow

148 The structure of C/EBPbeta DNA binding domain in complex with methylated DNA reveal

149 The two separate non-overlapping DNA binding domains in the ERCC1-XPF heterodimer jointly

150 affinity ssDNA-binding by RPA depends on two DNA binding domains in the large subunit of RPA.

151 l development and demonstrate a role for non-DNA binding domains in this process.

152 A crystal structure of the LIN54 DNA-binding domain in complex with a CHR sequence reveal

153 We crystallized the human CTCF DNA-binding domain in complex with a known CTCF-binding

154 we present the first structure of mouse GCNF DNA-binding domain in complex with the Oct4 DR0.

155 We identify a new DNA-binding domain in the large Cac1 subunit of CAF1, wh

156 We additionally identify a nearby DNA-binding domain in UBN1, located between the UBN1 HRD

157 e lncRNAs with high affinity through its HMG DNA-binding domain in vitro.

158 dence for transcription factor tethering and DNA-binding domain-independent action.

159 is inhibited by the B isoform of Fru, whose DNA binding domain interacts with a short region of an L

160 e p53 protein (both full-length and isolated DNA-binding domain) into amyloid-type fibrils in vitro.

161 We show here that while the central DNA binding domain is essential for anchoring at parS, t

162 SOX9 affinity is through NF-Y and that SOX9 DNA binding domain is not necessary for SOX9 affinity to

163 The orientation of the DNA-binding domain is mediated by sequences in the N-ter

164 ragment, and that the region adjacent to the DNA-binding domain is pivotal to its homo-trimerization.

165 ation domains, amide exchange throughout the DNA-binding domains is decreased as if the entire domain

166 n binding domains, but not the canonical CXC DNA binding domain, is essential for the ability of CHT7

167 ID4, a transcriptional regulator lacking a DNA binding domain, is highly up-regulated in CEACAM1-tr

168 Mutations in p53 protein, especially in the DNA-binding domain, is one of the major hallmarks of can

169 , whose members share structurally conserved DNA-binding domains, is variably sensitive to methylatio

170 e hydroxylase domain in TET proteins and a J-DNA-binding domain (JDBD) that resides in the middle of

171 ructurally, Fox proteins feature a conserved DNA-binding domain known as forkhead.

172 dge distant sites on a DNA molecule with the DNA-binding domains located at each end of its strut-lik

173 y only a minor role in inhibition, while the DNA binding domain makes a greater contribution.

174 r, in cells stably expressing a PR-A or PR-B DNA-binding domain mutant (PRmDBD), P4-mediated transrep

175 ifferent AP-1 consensus sequences, GR and MR DNA-binding domain mutants, and siRNA knockdown or overe

176 males or heterozygous males with an ERalpha DNA-binding domain mutation knocked in (WT/KI) to produc

177 DNA-binding domain mutations that eliminated the ability

178 In addition to their DNA-binding domains, MYC proteins carry five regions of

179 PALB2 N-terminal DNA-binding domain (N-DBD) stimulates the function of RA

180 A novel classification of EBNA1 DNA binding domains, named QCIGP, results from phylogeny

181 -stabilized complex did not require the Chd1 DNA-binding domain nor the histone H4 tail and appeared

182 are composed of two domains, an N- terminal DNA binding domain (NTD) and a C- terminal motor domain

183 features of the BRC repeats tethered to the DNA binding domain of BRCA2.

184 nctions is dependent on joint binding to the DNA binding domain of ERCC1 and XPF.

185 peptides that interact specifically with the DNA binding domain of ERG.

186 The DNA binding domain of FOXO1 is essential for these funct

187 Two cysteines in the DNA binding domain of LasR do form a disulfide bond when

188 ordered C-terminal region of Artemis and the DNA binding domain of Ligase IV.

189 amino acids and have high similarity to the DNA binding domain of Myb related proteins.

190 Here, we show the crystal structure of the DNA binding domain of OsWRKY45 (OsWRKY45-DBD, i.e. the W

191 We also report that deletion of the DNA binding domain of the S. aureus BirA results in loss

192 By fusing the Chd1 remodeler to the DNA binding domain of the Saccharomyces cerevisiae Ume6

193 d glutamic acid residue located in the basic DNA binding domain of TWIST1, in two subjects with front

194 n amino-terminal region of Zta and the basic DNA binding domain of Zta in regulating Zta ubiquitinati

195 X-ray crystallography of the DNA binding domains of normal WT1, Q369R and Q369H in co

196 Here, we report a crystal structure of the DNA-binding domain of a model ASO-binding protein PC4, i

197 ns that associate with the dimerization- and DNA-binding domain of ATF4 (the bZIP domain) in mouse sk

198 was dependent on Rok and independent of the DNA-binding domain of DnaA.

199 tion of the dimerization residues of E2F7 or DNA-binding domain of E2F1 abolished the suppressive eff

200 matics, we dissect the interplay between the DNA-binding domain of Engrailed, a Drosophila TF, and th

201 The eponymous DNA-binding domain of ETS (E26 transformation-specific)

202 tryptophan substitution in the conserved ETS DNA-binding domain of FLI1.

203 ional structure of the DNA-binding site, the DNA-binding domain of GR and the quaternary structure of

204 status of the Lys 80 residue located in the DNA-binding domain of HSF1 as a critical factor in modul

205 Here, we have characterized the DNA-binding domain of human FoxP1 by integrating single-

206 Comparative modeling of the DNA-binding domain of human HSF1 facilitated the predict

207 We also identified a distinct DNA-binding domain of human Orc6, named as HsOrc6-DBD.

208 and a 4.7-Mb multigene deletion involved the DNA-binding domain of IKAROS.

209 ar dynamics simulations, we interrogated the DNA-binding domain of murine ETS1 alone and when bound t

210 a recurrent mutation of threonine 223 in the DNA-binding domain of OCT2.

211 ions, all resulting in coding changes in the DNA-binding domain of P53.

212 ough the NTR is generally considered the key DNA-binding domain of PARP-2, we report here that all th

213 int, which requires its interaction with the DNA-binding domain of PARP1.

214 and meiotic recombination, we humanized the DNA-binding domain of PRDM9 in C57BL/6 mice.

215 leukemia fusion protein, which contains the DNA-binding domain of Runt-related transcription factor

216 of the Sd-Yki complex by binding to the TEA DNA-binding domain of Sd.

217 ions affecting the coiled-coil domain or the DNA-binding domain of signal transducer and activator of

218 Daxx directly binds to the DNA-binding domain of Slug, impeding histone deacetylase

219 The N-terminal region of DNA-binding domain of STAT3 is responsible for the STAT3

220 The modular DNA-binding domain of TALEs can be reprogrammed to targe

221 eta) knockout mouse, created by removing the DNA-binding domain of the ERbeta gene or interruption of

222 -terminal ligand binding domain, but not the DNA-binding domain of the GR.

223 f conserved phosphorylation sites within the DNA-binding domain of the receptor.

224 ve compound fragments that interact with the DNA-binding domain of the response regulator AgrA from S

225 narrow or broad target specificity, and the DNA-binding domain of the transcription activator-like e

226 Here we show that the DNA-binding domain of the transposase targets the enzyme

227 poptosis by binding to the sequence-specific DNA-binding domain of the tumor suppressor protein and p

228 ription factors characterized by a conserved DNA-binding domain of three zinc fingers and a variable

229 We apply this framework to program the DNA-binding domains of modular transcription factors to

230 t cryo-electron microscopy structures of the DNA-binding domains of SOX2 and its close homologue SOX1

231 plexes defined interactions with the SH2 and DNA-binding domains of STAT3.

232 This flexibility allows the DNA-binding domains of the dimer to straddle the operato

233 able to facilitate contacts between the core DNA-binding domains of the tetramer.

234 he mechanisms by which missense mutations in DNA-binding domains of transcription factors can lead to

235 ely, on nucleosomal DNA and pack against the DNA-binding domain on DNA exiting the nucleosome.

236 Although PfAP2-I contains three AP2 DNA-binding domains, only one is required for binding of

237 ntly augmented and that its highly conserved DNA binding domain or the human homolog PC4 is sufficien

238 m that is affected by either mutation in the DNA-binding domain or dysregulation by overexpression of

239 effectors dependent on either the yeast Gal4 DNA-binding domain or that of VirG.

240 ind that missense changes within or near the DNA-binding domain (p.Arg507His and p.Arg377Trp) reduce

241 t in FOXE3 with an altered amino acid in the DNA-binding domain (p.Asp153His) that segregated with di

242 s identifies several bona fide crosslinks on DNA binding domains, paving the way for future large sca

243 Here we show that by fusing a programmable DNA-binding domain (pDBD) to Cas9 and attenuating Cas9's

244 Together, our data identify p53 DNA-binding domain phosphorylation as a druggable mechan

245 p53 tumor suppressor activity is reduced by DNA-binding domain phosphorylation to prevent aging and

246 localization patterns, often lack classical DNA-binding domains, presenting challenges in identifyin

247 C-binding factor (CTCF) is an 11 zinc finger DNA-binding domain protein that regulates gene expressio

248 Removal of its DNA-binding domain reduces the expression of PD-1 at the

249 haracterized phosphorylation in the p53 core DNA-binding domain regulates the DNA binding cooperativi

250 ily of transcription factors with an unusual DNA-binding domain related to excisionases of bacterioph

251 ealed that Redbeta consists of an N-terminal DNA binding domain, residues 1-177, and a flexible C-ter

252 Structural comparisons of DNA binding domains revealed that efficient nucleosome b

253 C-terminal region, which contains a putative DNA-binding domain, selectively senses double-stranded D

254 A and Fur as case examples, we also show how DNA-binding domain sequence similarity can yield confoun

255 found that three fru isoforms with different DNA binding domains show a division of labor on male agg

256 , an AtDDF2-specific substitution within the DNA-binding domain significantly reduces binding affinit

257 ly, we predict motifs for many TFs that have DNA-binding domains similar to those already characteriz

258 central and posterior groups based on their DNA-binding domain similarity.

259 egulatory properties of the TFs, such as the DNA-binding domain, specificities, or mode of interactio

260 Phosphorylated IRF3, independently of its DNA-binding domain, stimulates apoptosis through allevia

261 that the Rap1 C terminus interacts with the DNA-binding domain, suggesting a complex network of inte

262 nt line harboring a point mutation in the GR DNA-binding domain, suggesting a nontranscriptional rout

263 We have found that the C-terminal, DNA-binding domain (tandem-winged helix), the heterodime

264 tures of the Thermococcus gammatolerans McrB DNA-binding domain (TgDelta185) both alone and in comple

265 aracterized by the presence of an N-terminal DNA binding domain that functions in transcriptional reg

266 by artificial fusion of Mediator subunits to DNA binding domains that bind to their promoters has bee

267 The dimer contains two identical DNA binding domains that interact with the major groove

268 rated knockin mice with a mutation in the TR DNA-binding domain that abrogates binding to DNA and lea

269 C-terminal region a previously unappreciated DNA-binding domain that exhibits specific binding to G-q

270 otease domain, the PCNA interaction, and the DNA-binding domain that is necessary for protease activi

271 each other and demonstrate a position of the DNA-binding domain that is unfavorable for DNA binding.

272 n its dimerization with MAX, which creates a DNA-binding domain that recognizes specific sequences in

273 y, the antitoxin MqsA possesses a C-terminal DNA-binding domain that recognizes the [5'-AACCT(N)(2-4)

274 ween the LOV and basic region leucine zipper DNA-binding domain that together with LOV dimerization r

275 DNA polymerase beta has two DNA-binding domains that interact with the opposite side

276 polymerase identified to date; it lacks two DNA-binding domains (the thumb domain and 8-KD domain) c

277 a way that when DNA binds to the N-terminal DNA-binding domains, the nuclear localization signal bec

278 While the two McrBC complexes use different DNA-binding domains, these contribute to the same genera

279 Foxo1 forms a complex with RORgammat via its DNA binding domain to inhibit RORgammat activity.

280 Here, we uncover that fusing a DNA binding domain to the NPC basket protein Nup1 reduce

281 iptional assay based on a fusion of the GAL4 DNA-binding domain to the BRCA1 C terminus (amino acids

282 chers, ranging from evolutionary analysis of DNA-binding domains to predictive function modeling.

283 roperties, IL-10-based modeling predicts two DNA-binding domains, two amphipathic helices, and an in-

284 imensional structure of the highly conserved DNA-binding domain using solution NMR spectroscopy, the

285 the intrinsic specificities of the AR and GR DNA-binding domains using a refined version of SELEX-seq

286 ty proportionately, indicating that the VirG DNA binding domain was functional in plants.

287 targeting strategy: a Dlg4/PSD95 zinc finger DNA-binding domain was engineered and fused to effector

288 A DNA-binding domain was identified in the small subunit o

289 s a C-terminal basic-helix-loop-helix (bHLH) DNA binding domain which recognizes the enhancer-box (E-

290 We also show that the N-terminal DNA binding domain, which is required for both DNA bindi

291 ly controlled by two regulatory domains: the DNA-binding domain, which interferes with sliding when i

292 TALEs possess a highly repetitive DNA-binding domain, which is notoriously difficult to se

293 cific interactions between the oncoprotein's DNA-binding domain, which may be targeted for therapeuti

294 pendent motions of Omega-loops and PPARgamma-DNA binding domain with contacts susceptible to conforma

295 ed C-terminal linker (IDL) that connects the DNA binding domain with the 9 amino acid C-terminal acid

296 n factor directing reprogramming, contains a DNA binding domain with three consecutive C2H2 zinc fing

297 nd requires substantial reorientation of the DNA-binding domain with respect to the ATPase domains.

298 mmetric dynamics are illustrated in the four DNA-binding domains, with loop L1 switching from inward

299 This HTH constitutes a second DNA-binding domain within PAF53.

300 However, a second contact between the XPA DNA-binding domain (XPA DBD) and the RPA70AB tandem ssDN