ライフサイエンスコーパス: DNP

1 DNP boosts NMR signal intensities by factors of 10(2) to

2 DNP can enhance NMR signals by factors of 10-100, thereb

3 DNP enables the rapid acquisition with natural isotopic

4 DNP enhancements (epsilon) of between 40 and 90 at 105 K

5 DNP improved glucose tolerance and reduced hepatic steat

6 DNP is a sensitivity enhancement technique that transfer

7 DNP treatment increased energy expenditure by approximat

8 DNP-enhanced 2D (29)Si{(1)H}, (13)C{(1)H}, and (31)P{(1)

9 DNP-enhanced 2D (29)Si{(29)Si} J-mediated NMR analyses o

10 DNP-enhanced ssNMR data reveal a monotonic increase in c

11 DNP-enhanced ssNMR data reveal that conversion of confor

12 DNPs functionalized with the MUC1 aptamer and doxorubici

13 DNPs were immobilized onto a gold electrode by direct ad

14 1D DNP enhanced spectra acquired in this way are shown to c

15 rate of photolysis of 2,4-dinitrophenol (24-DNP), an important environmental toxin.

16 For example, 24-DNP and other nitro-aromatic compounds should readily ph

17 om transfer reaction to the photo-excited 24-DNP.

18 ed by more than an order of magnitude for 24-DNP dissolved in 1-octanol or embedded in secondary orga

19 stark contrast to the slow photolysis of 24-DNP in an aqueous solution, the photolysis rate is incre

20 ositional isomers of dinitrophenol, only 2,4-DNP has been used extensively by many researchers for de

21 the p-NO2 group toward the reactivity of 2,4-DNP-based probes.

22 Following a DNP and spin diffusion period, the microwave irradiation

23 In order to develop a DNPs-based biosensing platform, we have selected glucose

24 tween oppositely charged regions on adjacent DNP surfaces.

25 After DNP injection, the maximal CMRO2 in both striatum and co

26 NH3, CO, and pyridine, and (29)Si and (27)Al DNP-enhanced solid-state NMR spectroscopy.

27 obilized conjugates of bovine serum albumin (DNP-BSA) or mobile in a supported lipid bilayer (DNP-SLB

28 Conventional and DNP-enhanced solid-state NMR provides a molecular-level

29 ination of data obtained from high-field and DNP-enhanced MAS NMR spectroscopy together with time-res

30 mited to relatively low magnetic fields, and DNP at fields higher than 9.4 T significantly drops in e

31 ng dependence on the microwave frequency and DNP polarization time.

32 annels (incipient wetness impregnation), and DNP is performed at low temperatures in a very efficient

33 antigen-independent cytokinergic manner, and DNP-specific murine SPE-7 IgE is the most highly cytokin

34 M-to-DNP ratios, DNP charge is reversed, and DNP aggregates remain stable in suspension.

35 As a result, DBPs and DNPs exhibit stronger 2PA into the one-photon-allowed B

36 finity for PSMA and the ability to bind anti-DNP antibodies.

37 ize the biosensor platform, using model anti-DNP antibodies, with the ultimate goal of designing a ve

38 ts passively sensitized with monoclonal anti-DNP IgE also resulted in mast-cell degranulation and ove

39 Although soluble anti-DNP IgE binds uniformly across features for both pattern

40 (>10% ID/g) but had minimal binding to anti-DNP antibodies.

41 henyl (DNP) hydrazine and detected with anti-DNP antibody.

42 ) mice were injected intradermally with anti-DNP-IgE and intravenously with the antigen DNP-HSA.

43 cepsilonRI) and stimulated using the antigen DNP-BSA.

44 i-DNP-IgE and intravenously with the antigen DNP-HSA.

45 Here, we applied DNP NMR to investigate the structure of a protein contai

46 DNP technique, identification of appropriate DNP substrates, and approaches to increase hyperpolarize

47 an alternate route to color-center-assisted DNP using nitrogen-vacancy (NV) centers in diamond coupl

48 estion, six molecular probes using available DNP isomers were developed and investigated to evaluate

49 The basic DNP strategy is to irradiate the EPR transitions of a st

50 BSA) or mobile in a supported lipid bilayer (DNP-SLB).

51 mediate states was generated and analyzed by DNP-enhanced solid-state NMR.

52 phenomena occur in energy-depleted cells by DNP at 30 degrees C.

53 bolic switch in dCTP production triggered by DNP inhibition is accompanied by NSP up-regulation and c

54 By comparing the (13)C DNP response for different crystal orientations, we show

55 e demonstrate efficient microwave-free (13)C DNP through the use of consecutive magnetic field sweeps

56 We report CE DNP experiments at 211, 600, and 800 MHz using a new ser

57 The CE DNP enhancement for the TEMTriPol biradicals does not de

58 pite the hypometabolic state of these cells, DNP-MRSI of 1-(13) C-pyruvate and its downstream metabol

59 llow the future extension of the single-chip DNP microsystem approach proposed here up the THz(ESR)/G

60 ) moiety to the C7 end of ciprofloxacin (Cip-DNP) reduced protection due to resistance substitutions

61 Treatment of E. coli cultures with Cip-DNP selectively enriched an uncommon variant, GyrA-A119E

62 D-DNP can provide drastic signal improvements in NMR signa

63 D-DNP NMR-derived ranking, therefore, is capable of determ

64 rage repeatability of our state-of-the-art D-DNP NMR equipment for samples of metabolomic relevance (

65 sites, the signal enhancement provided by D-DNP leads to single-scan detection of the NOE buildup, d

66 ts in neutral and acidic environments from D-DNP NMR spectroscopy, corresponding to a pre-equilibrium

67 High signal gains in D-DNP enable rapid measurement of data sets characterizing

68 f components and estimation of kinetics in D-DNP experiments, which can be applied at a high level of

69 rpolarized samples increases throughput of D-DNP by the same factor, improving the applicability to m

70 aneous signal acquisition, a limitation of D-DNP for the screening of protein-ligand interactions is

71 This first report on the repeatability of D-DNP highlights the compatibility of the technique with t

72 ion therefore extends the applicability of D-DNP to in vitro studies with a wider range of metabolite

73 A method based on d-DNP NMR spectroscopy to study chiral recognition is desc

74 dissolution dynamic nuclear polarization (D-DNP) assisted by cross-polarization (CP) provides a reli

75 dissolution dynamic nuclear polarization (d-DNP) for the first time enabled hyperpolarized natural a

76 dissolution dynamic nuclear polarization (D-DNP) has emerged as a technique for enhancing NMR signal

77 dissolution dynamic nuclear polarization (D-DNP) is shown to increase sensitivity for observing the

78 dissolution dynamic nuclear polarization (D-DNP) to amplify signals of functional intermediates and

79 dissolution dynamic nuclear polarization (D-DNP) usually involves saturating the ESR transitions of

80 dissolution dynamic nuclear polarization (D-DNP), both in in vivo and in vitro contexts.

81 dissolution dynamic nuclear polarization (D-DNP).

82 dissolution dynamic nuclear polarization (D-DNP).

83 dissolution dynamic nuclear polarization (D-DNP).

84 dissolution dynamic nuclear polarization (D-DNP).

85 o optimize parameters of the semiautomated d-DNP system suitable for high-throughput studies.

86 We show that D-DNP can be performed efficiently with hybrid polarizing

87 dition of the electroporation pulse to the D-DNP experiment increases the signals of the downstream m

88 7 intermediate during the timescale of the D-DNP NMR experiment.

89 The combination of the D-DNP technique and protein immobilization may facilitate

90 Using D-DNP monitoring, we find that under our conditions (i) in

91 determination of binding mechanisms using D-DNP RD.

92 for membrane permeabilization for use with D-DNP in cell cultures.

93 Two-dimensional DNP MAS NMR of the silica-bound peptide and solution NMR

94 -dibenzo- (DBP) and syn-dinaphthoporphyrins (DNP), lowers the symmetry of the porphyrin skeleton.

95 rphyrins (DBPs) and syn-dinaphthoporphyrins (DNPs) were synthesized by [2 + 2] condensation of the co

96 itochondrial protonophore 2,4 dinitrophenol (DNP) has beneficial effects on NAFLD, insulin resistance

97 The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and widely used weight loss drug i

98 lycolysis inhibitor) plus 2,4-dinitrophenol (DNP; oxidative phosphorylation inhibitor).

99 f the mitochondrial uncoupler dinitrophenol (DNP) were compared using 16.4 T in isoflurane anesthetiz

100 ilizing surface-patterned 2,4 dinitrophenyl (DNP) ligands.

101 ained antibody-recruiting 2,4-dinitrophenyl (DNP) groups and iodine were synthesized and screened in

102 so far been labeled with 2,4-dinitrophenyl (DNP) hydrazine and detected with anti-DNP antibody.

103 We report that addition of a dinitrophenyl (DNP) moiety to the C7 end of ciprofloxacin (Cip-DNP) red

104 he highly immunogenic hapten, dinitrophenyl (DNP), which specifically targets the surface of free vir

105 olyether incorporating 1,5-dioxynaphthalene (DNP) and tetrathiafulvalene (TTF) units along with a 4,4

106 lyether containing two 1,5-dioxynaphthalene (DNP) and two TTF units) that is topologically isomeric w

107 ne) (CBPQT(4+)), and a 1,5-dioxynaphthalene (DNP) guest.

108 h viologen (V(2+)) and 1,5-dioxynaphthalene (DNP) recognition units using click chemistry.

109 ce imaging (MRI) sensitivity and dissolution DNP can be used to perform in vivo real-time (13)C MRI.

110 The recent development of rapid dissolution DNP methods has facilitated previously impossible in vit

111 n nitride (h-BN) to disperse the NPs doubles DNP enhancements and absolute sensitivity in comparison

112 osing an adequate solvent, (1)H cross effect DNP enhancements of over 80 can be obtained at 240 K.

113 at over a 2-fold improvement in cross-effect DNP enhancements can be achieved in MAS experiments on f

114 Here we report solid-state Overhauser effect DNP enhancements of over 100 at 18.8 T.

115 we demonstrate the possibility of efficient DNP transfer in polycrystalline samples of [Co(en)3Cl3]2

116 This charge reversal eliminates DNP attachment to model membranes containing the highest

117 To enable DNP experiments without major modifications of the formu

118 vity in comparison to previously established DNP SENS procedures, enabling challenging homonuclear an

119 ing governed by short electron T(1) and fast DNP transfer.

120 niform for DNP-SLB and edge-concentrated for DNP-BSA.

121 mental setup offers an attractive option for DNP-enhanced solid-state NMR on ordered membranes and pr

122 Established sample preparations for DNP SENS experiments on NPs require the dilution of the

123 g at the cryogenic temperatures required for DNP.

124 alternative sample preparation strategy for DNP MAS ssNMR studies of lipid membranes and integral me

125 g highly efficient polarization transfer for DNP.

126 shows distinctive distributions: uniform for DNP-SLB and edge-concentrated for DNP-BSA.

127 desirable and which would also benefit from DNP signal enhancement.

128 ecover the expected signal enhancements from DNP, we explored time domain experiments such as NOVEL w

129 ensing platform preparation (DNPs/Au and GOx/DNPs/Au systems) by atomic force microscopy (AFM), field

130 In particular, we report (1)H DNP-enhanced NMR experiments on liquid samples having a

131 ts, lead to large and relatively homogeneous DNP enhancements throughout the lipid bilayer and to an

132 IAA/DNP decreased ATP levels (p < 0.05) in cells.

133 IAA/DNP increased exosome secretion from mouse organ culture

134 IAA/DNP treatment (up to 10 uM each) was non-toxic and resul

135 Exosomes from IAA/DNP-treated or untreated cells had similar biological pr

136 3'-cAMP into 2'- and 3'-AMP), effects of IAA/DNP on exosome secretion were enhanced.

137 AMP mimicked the potentiating effects of IAA/DNP on exosome secretion.

138 The IAA/DNP combination is a powerful stimulator of exosome secr

139 ment of TRPM7 kinase function suppressed IgE-DNP-dependent exocytosis, slowed the cellular degranulat

140 extracellular Mg(2+) assured unperturbed IgE-DNP-dependent exocytosis, independently of TRPM7.

141 pen conformers exhibit dramatically improved DNP performance as compared to the closed counterparts.

142 ), we demonstrate a quadratic improvement in DNP through the investigation of a stable, water-soluble

143 angiotensin-converting enzyme inhibition in DNP.

144 evels could contribute to podocyte injury in DNP.

145 nsor for lactate determination that includes DNPs as nanomaterial.

146 To investigate DNP action, mice fed a high fat diet and housed at 30 de

147 MAS at 4.3 K, DNP, electron decoupling, and short recycle delays impro

148 with (64)Cu-L19K-FDNB than with (64)Cu-L19K-DNP and (64)Cu-L19K, with mean standardized uptake value

149 (64)Cu-L19K-(2,4-dinitrophenyl) ((64)Cu-L19K-DNP) and (64)Cu-L19K.

150 ion studies of (64)Cu-L19K-FDNB, (64)Cu-L19K-DNP, and the native (64)Cu-L19K were compared in HCT-116

151 ution constrain fits of the static wide-line DNP-enhanced (195)Pt spectrum, allowing the (195)Pt chem

152 hermogenesis) were treated with 800 mg/liter DNP in drinking water.

153 ut employing the enzyme lactate oxidase (LOx/DNPs/Au).

154 onstrated that substrates containing ACC/Lys(DNP) exhibit 7 to 10 times higher sensitivity than conve

155 We therefore propose that the ACC/Lys(DNP) pair can be considered a novel and sensitive scaffo

156 luorophore and 2,4-dinitrophenyl-lysine (Lys(DNP)) as the quencher.

157 -methoxy-coumarin-4-yl acetic acid (MCA)/Lys(DNP) substrates; thus, substantially lower amounts of su

158 new stable mono- and dinitroxide PAs for MAS DNP NMR where this principle is demonstrated.

159 The rapid progress of MAS DNP has been largely enabled through the understanding o

160 e spinning dynamic nuclear polarization (MAS DNP) has allowed atomic-level characterization of materi

161 Most commonly, MAS-DNP is based on the use of nitroxide biradicals as polar

162 ed as endogenous polarization agents for MAS-DNP, in enabling the detection of (17)O at a natural abu

163 e spinning-dynamic nuclear polarization (MAS-DNP) has developed as an excellent approach for boosting

164 polarization under magic angle spinning (MAS-DNP) could be used to dramatically increase the sensitiv

165 The results presented show that MAS-DNP from paramagnetic metal ion dopants provides an effi

166 ly demonstrates the possibility of using MAS-DNP to greatly facilitate the acquisition of 2D (29)Si-(

167 Lung inflation did not alter mean DNP within the slice (P = 0.10).

168 With a 5 ms DNP period, electron decoupling results in a 195 % incre

169 lectrode with undoped diamond nanoparticles (DNPs) and its applicability to the fabrication of electr

170 kinetic properties of diamond nanoparticles (DNPs) functionalized with the polycation poly(allylamine

171 ophan-phenylalanine dipeptide nanoparticles (DNPs) that can shift the peptide's intrinsic fluorescent

172 Rationally designed DNA nanoparticles (DNPs) have emerged as facile delivery vehicles because t

173 esis of proteinuria in diabetic nephropathy (DNP).

174 Here, we demonstrate new DNP-based measurements that extend (17)O solid-state NMR

175 c nuclear polarization surface enhanced NMR (DNP-SENS), Mossbauer spectroscopy, and computational che

176 ctly observed at natural abundance by (17) O DNP surface-enhanced NMR spectroscopy (SENS).

177 r example, we demonstrate the acquisition of DNP-enhanced 2D (113)Cd-(113)Cd correlation NMR experime

178 his work represents the first application of DNP-enhanced ssNMR to the characterization of peptide or

179 will pave the way for future applications of DNP in paramagnetically doped materials or metalloprotei

180 onses of M. spretus living in three areas of DNP (the reference) and surrounding areas (El Partido an

181 abundance, thereby extending the concept of DNP surface-enhanced NMR spectroscopy to the (17)O nucli

182 This first demonstration of DNP transfer from one paramagnetic metal ion to its diam

183 Micron-sized features of DNP are presented as densely immobilized conjugates of b

184 ped a controlled-release oral formulation of DNP, called CRMP (controlled-release mitochondrial proto

185 owave pulses enables improved observation of DNP-enhanced (13) C spins in direct dipolar contact with

186 c angle spinning (MAS) NMR by observation of DNP-enhanced NMR signals (T(1e) =40+/-6 ms, 40 mM trityl

187 However, the physiology of DNP has not been studied in detail because toxicity, inc

188 Our work establishes the power of DNP-enhanced (19)F MAS NMR spectroscopy for structural c

189 cle of PR and also demonstrates the power of DNP-enhanced solid-state NMR to bridge the gap between f

190 However, requirements of DNP probes such as biocompatibility, signal sensitivity,

191 ng can be facilitated tremendously by use of DNP-enhanced solid-state NMR spectroscopy.

192 Herein, we constructed a number of DNPs of rectangular and tubular shapes with varied dimen

193 {1+1} macrocycles (each containing also one DNP unit) of the isomeric [3]catenane exhibit slightly d

194 studied using MD simulations and Overhauser DNP-enhanced NMR.

195 Our results demonstrate that Overhauser DNP at high field provides efficient polarization transf

196 o create arrays of such sensors for parallel DNP-enhanced NMR spectroscopy of nanoliter and subnanoli

197 However, paramagnetic DNP polarizing agents can have deleterious effects on NM

198 ant ecological area of Donana National Park (DNP) and surrounding areas (SW Spain), where many migrat

199 In particular, DNP SENS provides molecular-level information about the

200 Density-normalized perfusion (DNP) magnetic resonance imaging data were obtained in he

201 high-frequency dynamic nuclear polarization (DNP) and (1)H-detected MAS techniques.

202 of dissolution dynamic nuclear polarization (DNP) and its translation to humans stimulated developmen

203 for low-field dynamic nuclear polarization (DNP) at or near room temperature, but hyperfine broadeni

204 angle spinning dynamic nuclear polarization (DNP) at temperatures around 100 K.

205 ancements from dynamic nuclear polarization (DNP) at temperatures below 30 K.

206 Dynamic nuclear polarization (DNP) can dramatically enhance the sensitivity of nuclear

207 Dynamic nuclear polarization (DNP) can enhance NMR sensitivity by orders of magnitude

208 ng dissolution dynamic nuclear polarization (DNP) enable the detection of NMR spectra from low-gamma

209 ontinuous wave dynamic nuclear polarization (DNP) experiments decreases at the high magnetic fields u

210 one to perform dynamic nuclear polarization (DNP) experiments using a single-chip-integrated microsys

211 Dynamic nuclear polarization (DNP) has recently emerged as a tool to enhance the sensi

212 DNMR) based on dynamic nuclear polarization (DNP) in a quantum Hall ferromagnet (QHF) is a highly sen

213 efficiency of dynamic nuclear polarization (DNP) in solid-state NMR studies.

214 Efficient dynamic nuclear polarization (DNP) in solids, which enables very high sensitivity NMR

215 Dynamic nuclear polarization (DNP) increases NMR sensitivity by transferring polarizat

216 cement through dynamic nuclear polarization (DNP) increases the sensitivity of metal detection to aff

217 ss-effect (CE) dynamic nuclear polarization (DNP) is a rapidly developing technique that enhances the

218 (HP MRS) using dynamic nuclear polarization (DNP) is a technique that has greatly enhanced the sensit

219 Dynamic nuclear polarization (DNP) is generally capable of enhancing NMR signals by tr

220 larization via dynamic nuclear polarization (DNP) is pivotal for boosting magnetic resonance imaging

221 ments in (19)F dynamic nuclear polarization (DNP) magic angle spinning (MAS) spectra at 14.1 T on HIV

222 Dynamic nuclear polarization (DNP) magic-angle spinning (MAS) solid-state NMR (ssNMR)

223 feasibility of dynamic nuclear polarization (DNP) magic-angle-spinning NMR techniques, along with a j

224 in vivo using dynamic nuclear polarization (DNP) magnetic resonance spectroscopic imaging (MRSI) of

225 me, the use of dynamic nuclear polarization (DNP) NMR for characterizing zeolites containing ~2 wt %

226 for high-field dynamic nuclear polarization (DNP) NMR spectroscopy.

227 g schemes with dynamic nuclear polarization (DNP) NMR.

228 Dynamic nuclear polarization (DNP) potentially offers significant improvements in this

229 gands, through dynamic nuclear polarization (DNP) surface enhanced NMR spectroscopy.

230 ished by using dynamic nuclear polarization (DNP) surface-enhanced solid-state NMR techniques.

231 nterest in the Dynamic Nuclear Polarization (DNP) technique to improve the signal to noise ratio of s

232 using standard dynamic nuclear polarization (DNP) techniques and their (15)N chemical shifts were fou

233 ty enhanced by dynamic nuclear polarization (DNP), provide direct evidence of shared covalent (29) Si

234 abundance with dynamic nuclear polarization (DNP), Pruski et al. were able to measure oxygen-proton d

235 plicability of dynamic nuclear polarization (DNP), which leads to sensitivity enhancements of 2 order

236 mensional (2D) dynamic nuclear polarization (DNP)-enhanced NMR techniques.

237 Here, we use dynamic nuclear polarization (DNP)-enhanced solid-state magic-angle spinning (MAS) NMR

238 Dynamic nuclear polarization (DNP)-enhanced solid-state NMR spectroscopy has been show

239 n the basis of dynamic nuclear polarization (DNP)-enhanced solid-state NMR, we were able to analyze t

240 copy (DRIFTS), dynamic nuclear polarization (DNP)-enhanced solid-state nuclear magnetic resonance (SS

241 ng dissolution dynamic nuclear polarization (DNP).

242 ancements from dynamic nuclear polarization (DNP).

243 lved in the biosensing platform preparation (DNPs/Au and GOx/DNPs/Au systems) by atomic force microsc

244 At higher NOM-to-DNP ratios, DNP charge is reversed, and DNP aggregates remain stable

245 At low NOM-to-DNP ratios, DNPs aggregate to a limited extent but retain a positive

246 Registered DNP images were normalized by the mean to estimate perfu

247 lumina with the acquisition of well-resolved DNP surface-enhanced (27)Al cross-polarization spectra.

248 he electrochemical behavior of the resulting DNPs/Au platform was studied.

249 ted in liposomes containing SL-lipids reveal DNP enhancement values over two times larger for KL4 com

250 We study the solvent DNP enhancement of both TEKPol and BDPA in OTP in the ra

251 Specifically, DNP MAS ssNMR experiments at 600 MHz/395 GHz on KL4 reco

252 arization surface-enhanced NMR spectroscopy (DNP SENS) allows the unambiguous description of the coor

253 arization surface enhanced NMR spectroscopy (DNP SENS) and density functional theory (DFT) calculatio

254 arization surface enhanced NMR spectroscopy (DNP SENS) has previously been demonstrated to enhance th

255 ion surface-enhanced (89)Y NMR spectroscopy (DNP SENS).

256 arization surface enhanced NMR spectroscopy (DNP-SENS), to obtain the (195)Pt solid-state NMR spectra

257 (tpatcn)], doubling the magic-angle-spinning DNP enhancement of the previous state-of-the-art [Gd(dot

258 C isotope, this experiment demonstrates that DNP NMR is sufficiently sensitive to observe spin system

259 They further show that DNP-enhanced solid-state NMR fills the gap for challengi

260 nce for the proposed mechanism and show that DNP-induced cross-relaxation is a robust feature within

261 ent-refractory cancer cells, suggesting that DNP-MRSI provides a technology for this application.

262 We show that DNPs are photostable, biocompatible and have a narrow em

263 This study suggests that DNPs are effective tools for the systemic delivery of th

264 The DNP-containing M12L24 molecular flasks are effectively "

265 The DNP-NMR results corroborate the presence of MWW layers a

266 Additionally, the DNP sensitivity-enhanced two-dimensional (13)C/(13)C che

267 around the unpaired electron can change the DNP enhancement by an order of magnitude for two otherwi

268 d (13)C-substrates can be extracted from the DNP apparatus in the solid form, while maintaining the e

269 be described as emergent because neither the DNP subsetCBPQT(4+) nor the M12L24 assemblies exhibit th

270 urthermore, systematic quantification of the DNP enhancements as a function of biradical concentratio

271 This review presents the basics of the DNP technique, identification of appropriate DNP substra

272 Pharmacological co-targeting of the DNP with dT and the NSP with DI-39 was efficacious again

273 kly tuned on-resonance with electrons on the DNP polarizing agent.

274 Surprisingly, we find that the DNP enhancement decreases only relatively slowly for tem

275 icate that the microwave field (and thus the DNP enhancement) is inhomogeneous in the sample, and we

276 he TTF unit, the CBPQT(4+) ring moves to the DNP unit, producing a red color.

277 The visible emission signal allows the DNPs to act as imaging and sensing probes.

278 The siRNA delivered by the DNPs inhibited cell growth both in vitro and in vivo, wh

279 ned peaks were observed corresponding to the DNPs oxidation/reduction at the underlying gold electrod

280 temperature that is below thermoneutrality, DNP treatment had no effect on body weight, adiposity, o

281 Hall phases; however, the mechanism of this DNP and, in particular, the role of quantum Hall edge st

282 Thus, DNP makes structural studies of proteins at endogenous l

283 Suwannee River NOM induces changes to DNP hydrodynamic diameter and apparent zeta-potential in

284 The NOM-induced changes to DNP properties alter subsequent interactions with model

285 the contributions of bulk and edge states to DNP in QHF.

286 HCl) in a manner that depends on the NOM-to-DNP concentration ratio.

287 Diamond nanoparticles at low NOM-to-DNP ratios attach to model membranes to a larger extent

288 At higher NOM-to-DNP ratios, DNP charge is reversed, and DNP aggregates r

289 At low NOM-to-DNP ratios, DNPs aggregate to a limited extent but retai

290 es and provides a general perspective toward DNP at ambient temperatures.

291 de, which demonstrate that, although undoped DNPs have an insulating character, they show electrochem

292 Nonetheless, few studies have used DNPs to deliver siRNAs in vivo, and none has demonstrate

293 results demonstrate the feasibility of using DNP-enhanced NMR techniques to measure and assess dilute

294 [1-(13)C]-l-alanine ethyl ester, as a viable DNP probe whose chemical shift is sensitive to the physi

295 n decoupling experiments in conjunction with DNP and magic-angle-spinning NMR spectroscopy.

296 on of a small number of specific labels with DNP NMR enables determination of architectural informati

297 re demonstrated to be readily performed with DNP and provide the bonding motifs between the QD surfac

298 everse micelle encapsulation technology with DNP offers a route to a significant increase in the sens

299 Without DNP, no (119)Sn resonances were detected after 10 days o

300 cessible in conventional experiments without DNP, for protein structure determination.