ライフサイエンスコーパス: DOPC

1 DOPC and PGPC separate into vesicles and micelles.

2 DOPC lipid layers, containing small amounts of biotin-DO

3 DOPC/SM and POPC/SM binary mixtures yielded PWR spectra

4 mperature, T(mix) = 25-35 degrees C (for 1:1 DOPC/DPPC with 15%, 20%, 25%, and 30% Chol).

5 xed with 30% cholesterol: 2:1 DOPC/DPPC, 1:1 DOPC/DPPC, and 1:2 DOPC/DPPC.

6 serve phase transitions in vesicles of 1:1:1 DOPC/DPPC/sterol within giant unilamellar vesicles.

7 lipid ratios mixed with 30% cholesterol: 2:1 DOPC/DPPC, 1:1 DOPC/DPPC, and 1:2 DOPC/DPPC.

8 Conversely, if 1:2 DOPC/DPPC raft-like model membranes are used, cholestero

9 terol: 2:1 DOPC/DPPC, 1:1 DOPC/DPPC, and 1:2 DOPC/DPPC.

10 using giant unilamellar vesicles made of 7:3 DOPC/DOPG.

11 s at elevated tensions, about 3 mN/m for 30% DOPC/70% DPPC.

12 DPPC-rich liquid-ordered (L(o)) phase and a DOPC-rich liquid-disordered (L(d)) phase.

13 ments of the G(t)/rhodopsin interaction in a DOPC/DOPE (25:75) bilayer at pH 5 demonstrated that ligh

14 single halothane molecule partitioned into a DOPC lipid bilayer were performed to probe the free ener

15 ion of placental alkaline phosphatase into a DOPC/SM binary bilayer occurred with preferential insert

16 omposition used here was a modification of a DOPC/DPPC/cholesterol mixture known to form micrometer-s

17 yl phosphatidylethanolamine and gramicidin A-DOPC, small-angle x-ray scattering and (31)P-nuclear mag

18 yl phosphatidylethanolamine and gramicidin A-DOPC, which form the negatively curved hexagonal-II (H(I

19 e, R0 = -26 A (experimentally ~ -29.2 A) and DOPC leaflets preferring to be approximately flat (R0= -

20 es used are predominantly DOPC/DPPC/Chol and DOPC/BSM/Chol, which have been previously shown to produ

21 for two ternary mixtures (DOPC/DSPC/CHOL and DOPC/DPPC/CHOL) at different cholesterol concentrations.

22 nd lipid:cholesterol mixtures (SOPC:chol and DOPC:chol).

23 erol and CTAB (1/1 mol %) or cholesterol and DOPC (2/8 mol %) and incorporating two membrane dyes wer

24 hosphatidyl choline (DPPC), cholesterol, and DOPC are also presented.

25 and -20 degrees C for DPPC, DMPC, DLPC, and DOPC, respectively.

26 polypeptide in mechanically-aligned DMPC and DOPC bilayers.

27 ilamellar vesicles (GUVs) made from DOPC and DOPC/DOPE mixtures.

28 the extent of DRM formation in DOPC/DPPC and DOPC/SM bilayers and ordered lipid phase separation in m

29 hatidylcholine) in their outer leaflets, and DOPC in their inner leaflets.

30 ngle spinning conditions resolves the SM and DOPC headgroup resonances allowing for extraction of the

31 mol %), a mixture of SM (sphingomyelin) and DOPC (dioleoylphosphatidylcholine) in their outer leafle

32 creased by addition of phospholipids such as DOPC, DOPE, and DOPS and asolectin to detergent-containi

33 With phospholipids such as DOPC, giant unilamelar vesicles (GUV) are formed.

34 n-glyero-3-phosphocholine (DOPC), as well as DOPC vesicles, were used as model cell membranes.

35 ansducin (G alpha beta gamma) in an all-atom DOPC (1,2-dioleoylsn-glycero-3-phosphocholine) membrane-

36 n a protic environment, calix[6]tube 4 binds DOPC much more strongly than 5 and 6, thanks to the high

37 ing that 24:1 SM is able to accommodate both DOPC and CHO, forming a single phase.

38 In both DOPC and DEuPC vesicles DD and KK substitutions abolishe

39 The results show that in both DOPC- and DMoPC-containing bilayers, membrane-inserted r

40 tion of phase domains as POPC is replaced by DOPC.

41 e, cholesterol is preferentially solvated by DOPC if it is available, but if DOPC is replaced by POPC

42 e of inhomogeneity (DI) was similar for Chol/DOPC vesicles prepared by both procedures.

43 yl-sn-glycero-3-phosphochol ine/cholesterol (DOPC/DPPC/Chol), which is a model for the outer leaflet

44 idylethano lamine/sphingomyelin/cholesterol (DOPC/DOPE/SM/CH, 35:30:15:30) sonicated vesicles.

45 prepare compositionally uniform cholesterol/DOPC liposomes to avoid the problem of lipid demixing.

46 yl choline or dioleoyl phosphatidyl choline (DOPC).

47 itions of egg sphingomyelin, trans DOPC, cis DOPC, and cholesterol.

48 By comparing DOPC- with POPC-made membranes, we observed that the rat

49 nd robust digital optical phase conjugation (DOPC) implementation for suppressing multiple light scat

50 um, and a digital optical phase conjugation (DOPC) system characterizes and plays back the wavefront

51 10 mol % cholesterol for bilayers containing DOPC or POPC and was accompanied by maintenance of a con

52 bilayers in L-S phase coexistence containing DOPC, POPC, and DLPC, respectively.

53 finally it became aggregated in conventional DOPC, POPC, and DMPC membranes due to hydrophobic mismat

54 ary disorder of the acyl chains of neat L(d) DOPC bilayers.

55 bis-SorbPC and dioleoylphosphatidylcholine (DOPC) revealed a similar NMCL when the bis-SorbPC conten

56 ter leaflet and dioleoylphosphatidylcholine (DOPC), POPC, 1-palmitoyl-2-oleoyl-phosphatidyl-L-serine

57 mine (DOPE) and dioleoylphosphatidylcholine (DOPC), the proteins produced a dose-related effect on cu

58 cholesterol and dioleoylphosphatidylcholine (DOPC).

59 ine (DPPC), and dioleoylphosphatidylcholine (DOPC).

60 C approximately dioleoylphosphatidylcholine (DOPC)<1,2-dioleoyl-sn-glycero-3-[phospho-rac-(1-glycerol

61 choline (DMPC), dioleoylphosphatidylcholine (DOPC), and 1-palmitoyl-2-oleoyl-phosphatidylcholine (POP

62 choline (DPPC), dioleoylphosphatidylcholine (DOPC), and cholesterol show that oxygen and water transi

63 ant width, i.e. dioleoylphosphatidylcholine (DOPC) bilayers), while poly(LeuAla) core peptides formed

64 mide analogs in dioleoylphosphatidylcholine (DOPC) bilayers has been examined.

65 amine (DOPE) in dioleoylphosphatidylcholine (DOPC) bilayers.

66 orientations in dioleoylphosphatidylcholine (DOPC)and dilauroylphosphatidylcholine (DLPC) bilayer mem

67 exchanged into dioleoylphosphatidylcholine (DOPC) GUVs, lateral diffusion in the bSM-containing oute

68 , low-Tm lipid (dioleoylphosphatidylcholine (DOPC) or 1-palmitoyl 2-oleoyl phosphatidylcholine (POPC)

69 plied to a neat dioleoylphosphatidylcholine (DOPC) bilayer at 66% relative humidity and to the same b

70 les composed of dioleoylphosphatidylcholine (DOPC) adopted a topography in which the polyLeu sequence

71 n the system of dioleoylphosphatidylcholine (DOPC) and dioleoylphosphatidylethanolamine (DOPE) did no

72 xture either of dioleoylphosphatidylcholine (DOPC) and dioleoylphosphatidylglycerol (DOPG) or of dimy

73 imolar ratio of dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC) and vari

74 les composed of dioleoylphosphatidylcholine (DOPC), all of the peptides with single substitutions ado

75 m consisting of dioleoylphosphatidylcholine (DOPC), egg sphingomyelin (eSM), and cholesterol (Chol).

76 s consisting of dioleoylphosphatidylcholine (DOPC), palmitoyloleoylphosphatidylcholine (POPC), sphing

77 aturated lipid (dioleoylphosphatidylcholine, DOPC).

78 -forming lipid (dioleoylphosphatidylcholine; DOPC).

79 -ns duration, of dioleylphosphatidylcholine (DOPC), sphingomyelin (SM), and cholesterol (Chol) system

80 a fully hydrated dioleylposphatidylcholine (DOPC) bilayer.

81 een the ordered SM region and the disordered DOPC region in the ternary system and accelerates the pr

82 ase regime occurs at relatively narrow DOPC/(DOPC+POPC) ratios.

83 hase window shifts to higher values of DOPC/(DOPC+POPC) when CHOL concentration is increased, and coe

84 with the four lipid components DOTAP, DOPE, DOPC, and DSPE-PEG(2000).

85 simulations of human VDAC isoform 1 in DOPE/DOPC mixed bilayers in 1 M KCl solution with transmembra

86 nary membrane vesicles composed of DOPG:DOPE:DOPC with a charge density fixed at typical bacterial va

87 a drastically lower threshold ratio of DOPE:DOPC = 1.5:1.

88 ctive AMO requires a threshold ratio of DOPE:DOPC = 4:1, and the nonspecifically active AMO requires

89 erent single-component lipid bilayers (DPPC, DOPC, and DOPE).

90 domethacin enhanced phase separation in DPPC/DOPC/Chol (1:1:1) and DPPC/Chol membranes in a temperatu

91 disordered (L(d)) and L(o) bilayers of DPPC/DOPC/cholesterol is 1.75 +/- 0.35, in very good agreemen

92 of the phase diagram of the tensionless DPPC/DOPC/Cholesterol lipid bilayer.

93 , we constructed a phase diagram of the DPPC/DOPC/ergosterol system at 20 vol % ethanol.

94 We simulate DPPC:DOPC and DPPC:DOPC:cholesterol lipid bilayers to investigate phase tra

95 We simulate DPPC:DOPC and DPPC:DOPC:cholesterol lipid bilayers to investi

96 oyl-sn-glycero-3-phosphocholine (DOPC):DSPC, DOPC:1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC),

97 leoyl-phos phatidylcholine/cholesterol (DSPC/DOPC/POPC/CHOL) mixture displays a nanoscopic-to-macrosc

98 ns were depleted in unsaturated lipid (i.e., DOPC) and thus rich in cholesterol.

99 The addition of 40% cholesterol to either DOPC or DPPC changes the WAXS pattern due to an increase

100 When 40% cholesterol is added to either DOPC or DPPC, S(x-ray) more than doubles, consistent wit

101 n of positively charged ethylphosphocholine (DOPC+) vesicles into poly(dimethylsiloxane) (PDMS) micro

102 f a T20-gp41 complex embedded in an explicit DOPC membrane was constructed, and molecular dynamics si

103 orescein, which is coembedded into the fluid DOPC membrane.

104 obile fraction and diffusion coefficient for DOPC+ membranes remain virtually unchanged during this p

105 at an initial rate, which is comparable for DOPC and DPPC but is doubled for POPC.

106 es into the bilayers in increasing order for DOPC, POPC, and DPPC, while the amount of enzyme adsorbe

107 lowing a diffusion-limited growth regime for DOPC and in the case of POPC a homogeneous nucleation pr

108 A high selectivity for DOPC over dodecylphosphocholine (DPC) was also observed,

109 h increasing water content for DOPS than for DOPC, indicating greater perturbation of interlamellar w

110 er fluctuations are smaller in DOPS than for DOPC, showing that B and/or K(C) are larger.

111 cone shape to DOPC, and PGPC separates form DOPC.

112 r destruction at 25 degrees C decreases from DOPC to POPC and is dramatically reduced for DPPC.

113 and molecular packing density in going from DOPC to POPC to SM single component bilayers, as expecte

114 giant unilamellar vesicles (GUVs) made from DOPC and DOPC/DOPE mixtures.

115 Furthermore, DOPC-encapsulated siRNA targeting the oncoprotein EphA2

116 1,2-dioleoyl-sn-glycerophosphatidylcholine (DOPC) exhibit the well-known lamellar phase at 90 mol %

117 or bacterial toxin was developed with 5% GM1/DOPC+ membranes in PDMS channels, and a detection limit

118 solvated by DOPC if it is available, but if DOPC is replaced by POPC, cholesterol is preferentially

119 In DOPC bilayers, PCer forms a ceramide-rich phase at conce

120 In DOPC vesicles, most peptides repositioned so that the lo

121 ts maximum at P/L approximately 1/15-1/12 in DOPC bilayers.

122 n 3 for His(12) and about 3-5 for His(14) in DOPC membranes.

123 with the solubility limit of cholesterol in DOPC bilayers as independently measured by light scatter

124 ctrostatic domains induced by cholesterol in DOPC bilayers.

125 gnment and wavefront-matching constraints in DOPC, reflecting the requirement that the forward- and r

126 By contrast, in DOPC bilayers the affinity of G(t) for light-activated r

127 lve these nanoscale electrostatic domains in DOPC monolayers.

128 cally reduced the extent of DRM formation in DOPC/DPPC and DOPC/SM bilayers and ordered lipid phase s

129 nografted mice with miR-200c incorporated in DOPC nanoliposomes, we demonstrate anti-tumor activities

130 hannel, which was followed by an increase in DOPC and POPC or a further decrease in DLPC and DMPC bil

131 nalysis, for which the trans (cis) isomer in DOPC (DPPC) presents a fast decay time.

132 Nevertheless, in DOPC, we could estimate an apparent kink angle of approx

133 the magic angle) experiments carried out in DOPC/DOPE mixed lipid bilayers reveal a tilt angle of th

134 e exception of the KK-substituted peptide in DOPC vesicles, which formed a truncated TM segment.

135 igned spectrum of (15)N-labeled Leu39 PLB in DOPC/DOPE phospholipid bilayers was 220 ppm and is chara

136 to 9 A (a 13 residue hydrophobic sequence in DOPC bilayers).

137 a PP substitution maintained the TM state in DOPC vesicles, but in DEuPC vesicles the level of format

138 meter of a headgroup spin label DPP-Tempo in DOPC in excess water and partially dehydrated (10 wt % w

139 Remarkably, this was seen as well in DOPC-reconstituted Glu(134)- and Gln(134)-containing bov

140 fluorochrome Alexa 555 was encapsulated into DOPC liposomes and shown to be taken up by the tumor as

141 We propose that siRNA incorporated into DOPC nanoparticles could be delivered systemically and u

142 ally, exposure of membranes made of lamellar DOPC to halothane in concentrations close to clinically

143 ed; (ii) hydrogen-bonding between the lipid (DOPC) and the headgroup of 1, although extensive, is qui

144 aturated lipid (DPPC), an unsaturated lipid (DOPC), and ergosterol in the presence of high ethanol (2

145 anoliposomes prepared from different lipids (DOPC, POPC and DPPC) by thin film hydration method, were

146 oning between gel DPPC and disordered liquid DOPC domains with corresponding topography of domain str

147 ientations in the different lipid membranes (DOPC for the liquid disordered phase and DPPC for the ge

148 dylcholine (PC) layers in the microchannels, DOPC+ membranes show exceptionally strong resistance to

149 behavior of pure DPPC, pure DOPC, and mixed DOPC-beta-sitosterol bilayers solvated in a vitrificatio

150 Simulations of mixed DOPC/DOPE bilayers show that increase of the DOPE mole f

151 on as demonstrated for two ternary mixtures (DOPC/DSPC/CHOL and DOPC/DPPC/CHOL) at different choleste

152 ons of two different ternary lipid mixtures, DOPC/DPPC/Chol and POPC/PSM/Chol.

153 it the well-known lamellar phase at 90 mol % DOPC.

154 ted phase regime occurs at relatively narrow DOPC/(DOPC+POPC) ratios.

155 double-bond and water distributions of neat DOPC bilayers led to distributions that agreed with the

156 ation follows a diffusion law in the case of DOPC and a linear variation in the case of POPC.

157 dsorption trends indicate that the charge of DOPC+ membranes allows for tuning of solution conditions

158 Lipid bilayer membranes composed of DOPC, DPPC, and a series of sterols demix into coexistin

159 aped gel domains in GUV bilayers composed of DOPC/DPPC or DLPC/DPPC are observed by confocal fluoresc

160 s well-adapted to the native conformation of DOPC.

161 NTPs in a mixed lipid membrane consisting of DOPC lipid with a variable percentage of DMPC lipid adde

162 With an increasing mol fraction of DOPC, the response to the proteins increased, reaching a

163 nti-Stokes Raman scattering (CARS) images of DOPC/DPPC-d62 bilayers.

164 ixture of DOPC/SM/Chol, and a 1:1 mixture of DOPC/SM.

165 olesterol (Chol) systems, a 1:1:1 mixture of DOPC/SM/Chol, and a 1:1 mixture of DOPC/SM.

166 upported membranes consisting of mixtures of DOPC and cholesterol exhibit large-area striping reminis

167 unilamellar vesicles composed of mixtures of DOPC or DPPC and cholesterol are not sensitive to choles

168 phase behavior is observed for monolayers of DOPC/DPPC/Chol and for monolayers of POPC/PSM/Chol.

169 With respect to the membrane normal of DOPC or DPPC lipid bilayer membranes, GWALP23-R14 shows

170 Increasing the PLR of DOPC proteoliposomes up to 1:200 increased their osmotic

171 rface charge, since the isoelectric point of DOPC is ca. 4.

172 It will be shown that the presence of DOPC and/or cholesterol greatly impacts the headgroup mo

173 red domain changes the packing properties of DOPC bilayer at a distance as large as approximately 8 n

174 (GUVs) containing phase-separated regions of DOPC (soft, liquid) and DPPC (stiff, gel), with choleste

175 ol locally increases the bending rigidity of DOPC membranes, similar to saturated membranes, by incre

176 As demonstrated in the study, use of DOPC nanoliposomes for anti-miR delivery serves as a bet

177 ated phase window shifts to higher values of DOPC/(DOPC+POPC) when CHOL concentration is increased, a

178 The deposition of MWNTs on DOPC vesicles under favorable deposition conditions did

179 sing DOTAP with either neutral lipid DOPE or DOPC.

180 Vesicles prepared from pure DPPC or DOPC, with gel to liquid-crystal transition temperatures

181 ixtures with dioleoyl-PC (DOPC) and DPPC, or DOPC and sphingomyelin (SM).

182 molecules do not show a preference for SM or DOPC.

183 assignments of SLN in mechanically oriented DOPC/DOPE lipid bilayers as mapped by 2D (15)N PISEMA ex

184 asymmetric vesicles composed of SM outside, DOPC inside (SMo/DOPCi) or SM outside, 2:1 mol:mol POPE:

185 sterol-containing asymmetric SM+DOPC outside/DOPC inside vesicles, but ordered domain formation was c

186 rated lyso-PLs were preferred co-lipids over DOPC because of the nature of their acyl chain.

187 eractions between P(4,5)BP and PtdIns(4,5)P2/DOPC+/PEG-PE membrane were observed as expected, while c

188 esterol, and either unsaturated dioleoyl PC (DOPC) or 1-palmitoyl 2-oleoyl PC (POPC).

189 afts) in tertiary mixtures with dioleoyl-PC (DOPC) and DPPC, or DOPC and sphingomyelin (SM).

190 of 1,2-dioleoyl-sn-glycero-3-phophocholine (DOPC).

191 2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) for efficient in vivo siRNA delivery.

192 2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC) nanoliposomes, we show that miR-192 delivery leads

193 -dioleoyl-sn-glycerol-3-phosphatidylcholine (DOPC) structurally stabilize the complex to varying degr

194 2-dioleoyl-sn-glycero-3-phosphatidylcholine (DOPC)] to decrease melanoma growth and metastasis in viv

195 taining either dioleoyl phosphatidylcholine (DOPC) or the neutral and phospholipids isolated from cal

196 cholesterol in dioleoyl-phosphatidylcholine (DOPC) lipid bilayers at high cholesterol concentration (

197 nanoliposomes (dioleoyl phosphatidylcholine, DOPC) containing small interfering RNA (siRNA) targeted

198 ipid (DMPC, dimyristoyl phosphatidylcholine; DOPC, dioleoyl phosphatidylcholine) to the negatively ch

199 y(ethylene glycol)-phosphatidylethanolamine (DOPC+/PEG-PE) system stands out as the best performer th

200 er 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) (fluid at room temperature) or 1,2-dipalmitoyl-sn-

201 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) containing 4 mol % biotinylated-cap-1,2-dioleoyl-s

202 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) in nonpolar solvents.

203 ed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid bilayer were investigated by both second-har

204 ed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipid monomer.

205 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) lipids, with embedded alpha-helical peptide bundle

206 se 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) liposomes contacting a titanium dioxide substrate.

207 ng 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) nanoliposomes resulted in increased tumor growth a

208 ade of dioleoyl-sn-glycero-3-phosphocholine (DOPC) or 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholin

209 a 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) phospholipid bilayer via multi-nanosecond molecula

210 nt 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) vesicles on porous anodic aluminum oxide (AAO) mem

211 ), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and 1,2-dierucoyl-sn-glycero-3-phosphocholine (DE

212 ), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and 1-palmitoyl-2-oleoylphosphatidylcholine (POPC

213 ), 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), and cholesterol was studied with static and magic

214 nic 1,2-dioleoyl-sn-glyero-3-phosphocholine (DOPC), as well as DOPC vesicles, were used as model cell

215 ol 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), binds directly to S6K and causes an approximately

216 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), could be readily distinguished by evaluating diff

217 ol/1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), focusing on the importance of the hydrophobic par

218 d, 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)-based proteoliposomes were found to have excellent

219 ed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

220 in 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

221 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

222 as 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

223 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).

224 nd 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dihexadecanoyl-sn-glycero-3-phosphocholine (DP

225 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dioleoyl-sn-glycero-3-phosphate (DOPA) bilayer

226 s [1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC)

227 of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/cholesterol and 1,2-dipalmitoyl-sn-glycero-3-phosp

228 s (1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC):DSPC, DOPC:1,2-dipalmitoyl-sn-glycero-3-phosphocho

229 o a 1,2-dioleoyl-sn-glycero-3-phosphocoline (DOPC) bilayer.

230 ar dynamics (MD) in a hydrated phospholipid (DOPC) bilayer, a Monte Carlo search, and synthesis of lo

231 whereby tN-Ras binding was higher on planar DOPC than POPC membranes, but inversely higher on curved

232 protein in three lipid membranes, POPC/POPG, DOPC/DOPG, and DOPE.

233 The lipid mixtures used are predominantly DOPC/DPPC/Chol and DOPC/BSM/Chol, which have been previo

234 t degree of nonspecific adsorption to a pure DOPC bilayer, compared to avidin and streptavidin.

235 investigate the behavior of pure DPPC, pure DOPC, and mixed DOPC-beta-sitosterol bilayers solvated i

236 minimal effect on the phase behavior of pure DOPC at any temperature.

237 ts of detection on the dehydrated/rehydrated DOPC+/PEG-PE membranes were determined to be 33 nM for a

238 nal phase even when DOPE completely replaces DOPC.

239 on within the more ordered, cholesterol-rich/DOPC-poor/GM1-rich micrometer-scale phase, while GM1-ric

240 nding, disordered, cholesterol-poor/PSM-rich/DOPC-rich interdomain phase.

241 were found in mice treated with PAR-1 siRNA-DOPC.

242 ministration of S1MP loaded with-EphA2-siRNA-DOPC substantially reduced tumor burden, angiogenesis, a

243 ministration of S1MP loaded with EphA2-siRNA-DOPC.

244 eeks of treatment with EphA2-targeting siRNA-DOPC (150 microg/kg twice weekly) reduced tumor growth w

245 When EphA2-targeting siRNA-DOPC was combined with paclitaxel, tumor growth was dram

246 cted in cholesterol-containing asymmetric SM+DOPC outside/DOPC inside vesicles, but ordered domain fo

247 he atomistic simulations in a fully solvated DOPC lipid bilayer, the first (CNpNC) channel preserves

248 properties by using different lipids (SOPC, DOPC, or POPC) and lipid:cholesterol mixtures (SOPC:chol

249 In experiments with the lipids SOPC, DOPC, DPPC, and cholesterol we demonstrated that 1H MAS

250 myosin Va are able to transport fluid-state DOPC vesicles at velocities significantly faster (>700 n

251 kness between the domain and the surrounding DOPC bilayer.

252 x at a position corresponding to a synthetic DOPC lipid molecule in the cyanobacterial complex.

253 es, but inversely higher on curved POPC than DOPC membranes.

254 are less sensitive to osmotic pressure than DOPC headgroups, which is consistent with a larger K(C)

255 ting that MWNTs did not severely disrupt the DOPC bilayers upon attachment.

256 For the DOPC-melittin system, the experimental transbilayer dist

257 ngated conformation of 1 is preferred in the DOPC bilayer environment; however, many other conformati

258 When examined in the DOPC bilayer, it appeared that the association between p

259 presence of 20 mol% palmitoyl lyso-PC in the DOPC bilayer, the lateral segregation of PCer was marked

260 FCS data for the phospholipid probes in the DOPC fluid phase require two components (fast and slow).

261 outer leaflet decreased, whereas that in the DOPC-containing inner leaflet was largely unchanged, con

262 ort the observation of two new phases in the DOPC-DOPE system: a rhombohedral phase and a distorted h

263 pts a mixed strand/helix conformation in the DOPC/DOPG membrane, and is primarily a beta-strand in th

264 62-DPPC in the coexisting domains inside the DOPC/d62-DPPC (1:1) supported bilayers incorporated with

265 molecules spontaneously partitioned into the DOPC bilayer and then preferentially occupied regions cl

266 gh the insertion was less efficient into the DOPC bilayer.

267 n" state when the probe is inserted into the DOPC membrane, while it is in the "off" state in the DPP

268 The ordering of the DOPC acyl chains by cholesterol leads to retraction of t

269 Specific deuteration of the DOPC acyl-chain methyl groups and neutron diffraction me

270 kably smaller than the area 72.5 A(2) of the DOPC analog, despite the extra electrostatic repulsion e

271 lecules affect the hydrocarbon chains of the DOPC lipid, by lowering of the hydrocarbon tilt angles.

272 focal microscopy reveals that only 1% of the DOPC+ membrane in the microchannels was removed by the d

273 We provide a phase diagram of the DOPC/eSM/Chol mixture and predict the location of the cr

274 bilayers and in ternary systems based on the DOPC bilayers.

275 At high ionic strength the DOPC and DOPA lipids appear uniformly mixed.

276 ygen and water transit a leaflet through the DOPC and cholesterol rich boundaries of hexagonally pack

277 xhibits a major population that moves to the DOPC bilayer surface and a minor population that occupie

278 MSMP siRNA, delivered in vivo using the DOPC nanoliposomes, restored tumor sensitivity to anti-V

279 tion was also observed at pH 2, at which the DOPC SLBs exhibited positive surface charge, since the i

280 demonstrated that binding of Abeta (1-42) to DOPC bilayer, enriched with 20% cholesterol, resulted in

281 The measured adsorption rate for SBN to DOPC was 2.7 +/- 0.2 x 10(3) s(-1) M(-1) and the desorpt

282 oth unsaturated tails confer a cone shape to DOPC, and PGPC separates form DOPC.

283 PGPC is least similar to DOPC because mobilities of both unsaturated tails confer

284 Trans DOPC also alters the membrane curvature distribution; th

285 Trans DOPC induces some vesicles to form multidomain, invagina

286 Here, we test the effect of trans DOPC (dielaidoyl phosphatidylcholine or DEPC) on the mor

287 Addition of trans DOPC does not alter the l(o)/l(d) area fractions, indica

288 n in the l(o) phase in the presence of trans DOPC.

289 ing compositions of egg sphingomyelin, trans DOPC, cis DOPC, and cholesterol.

290 of meridional curvatures in GUVs with trans DOPC is suggestive of higher membrane bending rigidity.

291 with the extent of acyl chain unsaturation (DOPC:POPC ratio).

292 holesterol concentration, and of POPC versus DOPC, on the formation of ultrananodomains versus larger

293 alline phase transition temperature, whereas DOPC displays only minor variations in these lipid mixtu

294 icking and nuclear accumulation of DNA while DOPC-containing formulations remained within the late en

295 c, inverted hexagonal lipid structures while DOPC promotes more stable laminar structures.

296 ection efficiency than those formulated with DOPC, both in vitro and in vivo.

297 th DPPC and cholesterol, and immiscible with DOPC.

298 egregation property as DPPC when mixing with DOPC.

299 e segregation in ternary lipid mixtures with DOPC and CHO.

300 es of mixed anionic (DOPG) and zwitterionic (DOPC) content.