ライフサイエンスコーパス: DRG

1 DRG neuronal populations were identified by neurofilamen

2 DRG neurons of NGF(R100W/wt) mice are morphologically no

3 DRG neurons showed accumulation of cleaved caspase 3 (ap

4 We identified 538 PGMs in 98 DRGs (POLG, MUTYH, ERCC2, and BRCA2, among others) in 50

5 ture, which, in turn, controls splicing in a DRG-derived cell line.

6 Overall, our work uncovers a DRG neuron-microglia interaction that responds to G-CSF

7 to studies and screens using VTD to activate DRG neurons.

8 ity of uninjured nociceptors in the adjacent DRG that drives an outburst of pain.

9 ts of daily chemogenetic activation of adult DRG neurons for 12 weeks post-crush in vivo enhances axo

10 al root ganglion (DRG) neurons, and on adult DRG neuron sensitization to painful stimuli.

11 stem and indicate that loss of Jedi-1 alters DRG neuron activity indirectly through an intercellular

12 inct differences in mechanical allodynia and DRG gene expression, even though sex differences in IVD

13 ted TNF and CXCL1 in macrophage cultures and DRG tissues in both sexes, but these changes were compro

14 nerve, increased nerve signal intensity and DRG or spinal cord changes.

15 of future neural interface technologies and DRG-focused pharmaceutical therapies, and provide a rigo

16 veral findings of differences between TG and DRG nociceptors described in the literature but also sug

17 scriptome and translatome activity in TG and DRG nociceptors that enhances our understanding of nocic

18 usly unrecognized differences between TG and DRG nociceptors that provide new insight into how injury

19 in Scn10a-positive nociceptors in the TG and DRG of male and female mice.

20 located in the trigeminal ganglion (TG) and DRG are the primary sensors of damaging or potentially d

21 ments using pharmacological tools as well as DRG from ERbeta(-/-) mice indicate that this BPA effect

22 ransfected into the injured DRGs (defined as DRGs with injured spinal nerves) of living SNL rats.

23 In axotomized DRGs, few hematogenous leukocytes are detected and resid

24 lls in the injured nerve, but not axotomized DRGs, strongly express receptors for the cytokine GM-CSF

25 innervated by cervicovascular neurons in C2 DRG whose axons reach the posterior dura through multipl

26 in male rats, we found that neurons in C2-C3 DRGs innervate the dura of the posterior fossa; that nea

27 Whereas control DRG neurons failed to extend axons across the dorsal roo

28 xpression in neurons or glia in spinal cord, DRG, and nerve.

29 nges in the treated nerves and corresponding DRGs.

30 currents or mechanical threshold in cultured DRG neurons.

31 eleased in the exosomal fraction of cultured DRG following capsaicin activation of TRPV1 receptors.

32 e-cell patch clamp recordings using cultured DRG neurons and observed mechanically-activated (MA) cur

33 -Exos promoted neurite outgrowth of diabetic DRG neurons and migration of Schwann cells challenged by

34 normal, with no alteration in the different DRG subpopulations, whereas skin innervation is reduced.

35 Due to technical difficulties, DRG neuronal activity in awake behaving animals remains

36 gets and was co-expressed with CD40 in early DRG neurons.

37 CD40L was synthesized in early DRG targets and was co-expressed with CD40 in early DRG

38 intrinsic physiological properties of eight DRG neuron subtypes are presented.

39 The transcriptome profiles of eight DRG neuron subtypes revealed differentially expressed an

40 Interestingly, the mutation endows DRG neurons with multiple early afterdepolarizations and

41 how that the T790A mutation greatly enhances DRG neuron excitability by reducing current threshold an

42 Percoll-gradient enriched DRG and TG neuronal fractions produced distinct sex-depe

43 viral reactivation not only in the expected DRG but also in the sympathetic SSG.

44 ultured with human intrafusal muscle fibers, DRG organoid sensory neurons contact their peripheral ta

45 FRDA DRG organoids model some molecular and cellular deficits

46 ly revert the pathological hallmarks of FRDA DRG neurons.

47 Single axons arising from DRG were identified in the distal colon and their morpho

48 is of ex vivo H3K9ac ChIPseq and RNAseq from DRG followed by promoter acetylation and protein express

49 Recording in vivo from DRGs of mice, we observed irregular- and regular-spiking

50 Furthermore, DRG neurons expressing T790A channels exhibited reduced

51 ptors, are derived from dorsal root ganglia (DRG) and can undergo changes in membrane excitability du

52 ed with degeneration in dorsal root ganglia (DRG) and sciatic nerve and abundance of Schwann cells.

53 cular signatures of the dorsal root ganglia (DRG) and spinal cord response, not observed at the nerve

54 dent kinase 5 (Cdk5) in dorsal root ganglia (DRG) and spinal dorsal horn.

55 IP in the corresponding dorsal root ganglia (DRG) and the dorsal horn of the spinal cord.

56 lls and chick embryonic dorsal root ganglia (DRG) bodies, as well as the migration of Schwann cells.

57 The dorsal root ganglia (DRG) contain cell bodies of primary afferent neurons, wh

58 The dorsal root ganglia (DRG) contain the somas of first-order sensory neurons cr

59 d by von Frey assay and dorsal root ganglia (DRG) expression of Calca and Tac1 genes.

60 The dorsal root ganglia (DRG) house the primary afferent neurons responsible for

61 esident GFAP(+) glia in dorsal root ganglia (DRG) known as satellite glial cells (SGCs) potentiate ne

62 evels in fibroblasts in dorsal root ganglia (DRG) meninges and in the epi/perineurium of the sciatic

63 osomes communicate with dorsal root ganglia (DRG) neurons.

64 cubation of dissociated dorsal root ganglia (DRG) nociceptors with 1 nM BPA increases the frequency o

65 regenerative ability of dorsal root ganglia (DRG) sensory neurons compared to EE or a conditioning in

66 ion response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central

67 roRNAs (miRs) occurs in dorsal root ganglia (DRG) sensory neurons.

68 thologic changes in the dorsal root ganglia (DRG) through inflammation, altered metabolism, and neuro

69 from the autonomic and dorsal root ganglia (DRG) to the axon and any peripheral nerve fibre type.

70 2) is elevated in skin, dorsal root ganglia (DRG), and spinal cord in HbSS-BERK mice.

71 ry culture and in mouse dorsal root ganglia (DRG), as determined by the characteristic senescence mar

72 well known to reside in dorsal root ganglia (DRG), the morphology and location of peripheral nerve en

73 on protein, we isolated dorsal root ganglia (DRG), the primary sensory cell body for peripheral nerve

74 In dorsal root ganglia (DRG), there is an increase in CGRP(+), TH(+), and Iba1(+

75 Dorsal root ganglia (DRG), which contain the somata of primary sensory neuron

76 ns, with cell bodies in dorsal root ganglia (DRG).

77 nantly in thoracolumbar dorsal root ganglia (DRG).

78 ured sensory neurons in dorsal root ganglia (DRG).

79 sory cell bodies of the dorsal root ganglia (DRG).

80 afferent neurons of the dorsal root ganglia (DRG).

81 atent infections in the dorsal root ganglia (DRG).

82 a4, an nAChR subtype in dorsal root ganglia (DRG).

83 r alpha1 (GFRalpha1) in dorsal root ganglia (DRG).

84 nociceptive neurons of dorsal root ganglia (DRGs) and is implicated in pain modulation.

85 nd the transcriptome of dorsal root ganglia (DRGs) provide possible explanations for the increase in

86 nscriptome profiling of dorsal root ganglia (DRGs) revealed 138 differentially regulated genes in Glu

87 al nerve and axotomized dorsal root ganglia (DRGs).

88 is highly expressed in dorsal root ganglia (DRGs).

89 ere upregulated in the dorsal root ganglion (DRG) after chronic compression of DRG (CCD), and some CX

90 rations, such as whole dorsal root ganglion (DRG) and hindpaw tissues, revealed only a few sex-depend

91 alyses of rodent whole dorsal root ganglion (DRG) have revealed sex differences, mostly in immune cel

92 phorylation of ERKs in dorsal root ganglion (DRG) in a dose-dependent manner.

93 have described a human dorsal root ganglion (DRG) neuron culture model and human induced pleuripotent

94 n of mammalian PATs in dorsal root ganglion (DRG) neurons and, strikingly, found that only two PATs,

95 creased RNA binding in dorsal root ganglion (DRG) neurons compared with wild-type and non-phosphoryla

96 Our study shows that dorsal root ganglion (DRG) neurons contain at least two major functional K(v)1

97 4 potassium current in dorsal root ganglion (DRG) neurons contributes to the hyperexcitability associ

98 channels (VGSC) on the dorsal root ganglion (DRG) neurons controlling electrical impulses may have ab

99 In dorsal root ganglion (DRG) neurons cultured from rats primed with fentanyl, ro

100 which is known to make dorsal root ganglion (DRG) neurons hyperexcitable, but different pain profiles

101 ic activation of adult dorsal root ganglion (DRG) neurons improves axon growth on an in vitro model o

102 PM3 expressed in mouse dorsal root ganglion (DRG) neurons is inhibited by agonists of the Gi-coupled

103 led receptors in mouse dorsal root ganglion (DRG) neurons isolated from both sexes.

104 sitive channels in the dorsal root ganglion (DRG) neurons of these afferents.

105 eage (Vglut3(lineage)) dorsal root ganglion (DRG) neurons play an important role in mechanosensation

106 8-15) and with primary dorsal root ganglion (DRG) neurons resulted in significant neurite outgrowth a

107 ) conductance of mouse dorsal root ganglion (DRG) neurons was examined by the whole-cell patch-clamp

108 ained ASIC currents in dorsal root ganglion (DRG) neurons were enhanced by naturally occurring endomo

109 and differentiation of dorsal root ganglion (DRG) neurons, and on adult DRG neuron sensitization to p

110 mall-diameter (<30 um) dorsal root ganglion (DRG) neurons, cultured from fentanyl-primed rats, and ra

111 0.5 nm) was applied to dorsal root ganglion (DRG) neurons, cultured from opioid-primed rats, it induc

112 gene transcription in dorsal root ganglion (DRG) neurons, which may contribute to nerve injury-induc

113 ents in large-diameter dorsal root ganglion (DRG) neurons.

114 to promote latency in dorsal root ganglion (DRG) neurons.

115 hannel coupling in rat dorsal root ganglion (DRG) neurons.

116 Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo pr

117 on nociceptors in the dorsal root ganglion (DRG) to cause pain sensitization.

118 nociceptors within the dorsal root ganglion (DRG), and knockdown of Kv4.3 selectively induces mechani

119 evels of P2X(3) in the dorsal root ganglion (DRG), and the whole cell patch clamp was used to examine

120 adjacent uninjured L4 dorsal root ganglion (DRG), as revealed by both in vivo electrophysiological r

121 ns isolated from mouse dorsal root ganglion (DRG), native TRPM3 channels were inhibited by activating

122 own, but we found that dorsal root ganglion (DRG)-specific knockdown of Magi-1 attenuated thermal noc

123 nociceptive neurons of dorsal root ganglion (DRG).

124 on and duration of surgery as well as German DRG case-weight were significantly higher in the interve

125 Thus, based on the changes in dorsal horn, DRG and peripheral innervation, we suggest that the adul

126 ee-dimensional spatial organization of human DRG neural fibers and somata has not been quantitatively

127 simplex virus 1 (HSV-1) to infect the human DRG-derived neuronal cell line HD10.6 in order to study

128 Given that TRPC4 is expressed in human DRGs and a specific inhibitor is in clinical trials, our

129 erve injury-induced pain hypersensitivities, DRG DNMT1 contributes to neuropathic pain genesis partia

130 ct of fentanyl was reversed in weakly IB4(+) DRG neurons cultured from opioid-primed rats after in vi

131 Here, we develop a method for imaging DRG at cellular and subcellular resolution over weeks in

132 In DRG neurons cultured from rats with OIHP, enhanced PGE(2

133 In DRG neurons, siRNA knockdown of sodium channel beta4 sub

134 In DRG neurons, Zdhhc5/8 shRNA knockdown reduced Gp130 palm

135 vated MrgprD signaling to activate TRP-A1 in DRG neurons and in human embryonic kidney 293 cells, to

136 mulation of senescent-like neuronal cells in DRG is associated with cisplatin-induced peripheral neur

137 Surprisingly, we did observe changes in DRG neuron activity.

138 se association between all three channels in DRG neurons.

139 Knockdown of 9 chemokines in DRG neurons significantly reduced migration of PDAC cell

140 expression of all Kv4 complex components in DRG neurons is downregulated following spinal nerve liga

141 that increased Nav1.8 resurgent currents in DRG neurons greatly prolong action potential duration an

142 ualitative reports of neural distribution in DRG.

143 ase, have higher translational efficiency in DRG nociceptors.

144 wo PATs, ZDHHC5 and ZDHHC8, were enriched in DRG axons.

145 hibitors targeting key epigenetic enzymes in DRG neurons, we identified HDAC3 signalling as a novel c

146 The expressions of p-BTK and p-ERK in DRG primary cells reached maximum levels at 1 and 10 min

147 d up-regulation of phosphorylated (p)-ERK in DRG was considerably reduced in the IL-6 knockout mice.

148 The decrease in Nrg1 expression in DRG neurons of WD-fed mice may suggest an altered Nrg1-d

149 thymine DNA glycosylase-dependent fashion in DRG neurons.

150 ster ovary cells, supporting our findings in DRG neurons.

151 on of Bruton's tyrosine kinase (BTK) gene in DRG after CaP injection.

152 d the expression of pain-associated genes in DRG cultures.

153 on of sustained ASIC currents was greater in DRG neurons isolated from rats with ligated femoral arte

154 e, we report that RUNX1, expressed highly in DRG, binds HSV-1 genome, represses transcription of nume

155 roles of cytoskeleton and membrane lipids in DRG neuron mechanics.

156 ANO1-containing multichannel nanodomains in DRG neurons and suggest that coupling between TRPV1 and

157 ise from the same axon and sensory neuron in DRG.

158 dergic and nonpeptidergic sensory neurons in DRG are potentially capable of detecting sensory stimuli

159 r hand, the potentiation was not observed in DRG neurons from ASIC3 knockout rats.

160 sterior fossa; that nearly half originate in DRG neurons containing CGRP and TRPV1; that nerve bundle

161 observed the core protein BMAL1 and PER2 in DRG neurons and satellite cells.

162 mulate MNK-mediated eIF4E phosphorylation in DRG neurons to promote pain hypersensitivity.

163 suppressed spontaneous action potentials in DRG neurons occurring in rats with CIPN, while intrathec

164 sodium channel Na(v)1.7, which is present in DRG nociceptors and is essential in pain signaling.

165 ox signaling as shown by redox proteomics in DRG.

166 g that activation of adrenergic receptors in DRG neurons is preferentially linked to CaMKII activity.

167 bserved strong circadian reporter rhythms in DRG neurons which are highly entrainable by external cue

168 Type I IFNs stimulate JAK/STAT signaling in DRG neurons but this does not apparently result in PKR-e

169 Recently, we have revealed itch signaling in DRG neurons by which TRPC4 mediates itch to serotonergic

170 s an essential scaffold for ion transport in DRG neurons and a central player in pain.

171 We have also shown that silencing TRPC4 in DRG and its inhibition by intradermal injections were al

172 injury in mice, miR-21-5p is upregulated in DRG neurons and both intrathecal delivery of a miR-21-5p

173 roduction of PGE(2)-G over that of PGE(2) in DRGs, decreased mechanical and thermal hyperalgesia, and

174 the hypotheses that PGE(2)-G is increased in DRGs of HbSS-BERK mice and sensitizes nociceptors (senso

175 on of cAMP to inhibitory Galphai proteins in DRGs.

176 membrane permeability showed much increased DRG concentrations at doses of 30 mpk PO, but, confoundi

177 rophages and neutrophils infiltrate infected DRGs and account for the development of herpetic neuralg

178 mmediately after plantar formalin injection, DRG neuronal activity increases substantially and this a

179 the transcription factor CREB in the injured DRG after peripheral nerve injury.

180 DNA methyltransferase DNMT3a in the injured DRG neurons via the activation of the transcription fact

181 attenuated hyperexcitability in the injured DRG neurons, and alleviated nerve injury-induced pain hy

182 upregulated DNMT1 expression in the injured DRG through the transcription factor cAMP response eleme

183 ases in neuronal excitability in the injured DRG.

184 and DPP10 were transfected into the injured DRGs (defined as DRGs with injured spinal nerves) of liv

185 IP1, and DPP10 surface levels in the injured DRGs.

186 oss the dorsal root entry zone after injury, DRG neurons in which fidgetin was knocked down displayed

187 on of immune cells, such as macrophages into DRGs and their subsequent activation promote CIPN.

188 ed on large-diameter dorsal-root ganglion (L-DRG) neurons with myelinated axons.

189 tive antagonist, Dendrotoxin-K, in several L-DRG subclasses (L1, L2, L3, and L5), suggesting the pres

190 expression in the male since fluorescent L4 DRG neurons, innervating the hindlimbs and lower back, w

191 attenuated the spontaneous activities in L4 DRG and pain behavior.

192 rd may contribute to the sensitization of L4 DRG neurons after L5 SNT.

193 ages across the length of 31 human L4 and L5 DRG from 10 donors.

194 n genesis likely through repressing at least DRG Kcna2 gene expression in male mice.

195 aclitaxel treatment significantly lengthened DRG circadian periods, with little effects on the amplit

196 s showed that small-diameter Vglut3(lineage) DRG neurons fire menthol-evoked action potentials and ex

197 The left sixth and seventh lumbar DRG (L6-L7) were instrumented with penetrating and non-p

198 ctivity from primary afferents in the lumbar DRG using non-penetrating electrode arrays and to charac

199 tions of dextran-amine made into lumbosacral DRGs (L5-S2).

200 In cultured male DRG neurons, IP3 (100 mum) potentiated depolarization-in

201 We show that, in male DRG neurons, these mutations, which impair inactivation,

202 t type I IFNRs are expressed in small/medium DRG neurons and that their activation produces neuronal

203 While different gene variants may modulate DRG neuron excitability and thereby contribute to interi

204 Mouse DRG sensory neurons express GluK2, and GluK2 knockdown i

205 In cultured mouse DRG neurons, tacrolimus evokes an increase in intracellu

206 ly enhanced axon growth from embryonic mouse DRG neurons cultured at this early stage.

207 luorimetry analysis of male and female mouse DRG neurons demonstrated that the cooling compound menth

208 sed PTGDS protein and PGD(2) in female mouse DRG.

209 other voltage-gated sodium channels in mouse DRG are considered threshold channels because they produ

210 sensing above freezing temperatures in mouse DRG neurons.

211 ome sequencing data, we confirmed that mouse DRG neurons highly express Runx1 mRNA.

212 ast growth factor (FGF), FGF13, in the mouse DRG neurons selectively abolished heat nociception.

213 e transcriptome and translatome of the mouse DRG with the goal of identifying sex differences.

214 regulation, overexpression of RCAN1 in naive DRG neurons recapitulated the effects of pharmacological

215 transcriptional signature similar to native DRGs and display the main peripheral sensory neuronal an

216 fter oxaliplatin treatment in sciatic nerve, DRGs, or spinal cord tissue as revealed by untargeted an

217 al levels could be found in the inner 85% of DRG length, the outer-most 25-30% radially, and the dors

218 ng to synaptic transmission after axotomy of DRG neurons.

219 r is to review the bioelectrical behavior of DRG neurons, signaling complexity in sensory neurons, va

220 Our results demonstrated that clearance of DRG senescent neuronal cells reverses CIPN, suggesting t

221 ganglion (DRG) after chronic compression of DRG (CCD), and some CXCR4 immunopositive neurons were al

222 re we demonstrate a critical contribution of DRG macrophages, but not those at the nerve injury site,

223 rus in explanted ganglia and cryosections of DRG and the sacral sympathetic ganglia (SSG) from latent

224 examined on the background K(+) currents of DRG neurons.

225 ntribution to neuropathic pain, depletion of DRG macrophages reduces nerve injury-induced mechanical

226 MET-1 reduced the excitability of DRG neurons by significantly increasing rheobase, decrea

227 eria can directly impact the excitability of DRG neurons, through PAR-4 activation.

228 ated the effects of MET-1 on excitability of DRG neurons.

229 mechanical hypersensitivity and expansion of DRG macrophages in both male and female mice.

230 Repeated imaging of DRG over 5 weeks after formalin injection reveals persis

231 hysiological changes during HSV infection of DRG neurons, which may have implications for understandi

232 cological inhibition or genetic knockdown of DRG DNMT1 alleviated nerve injury-induced pain hypersens

233 lations as well as computational modeling of DRG neuron subtypes were undertaken to assess the functi

234 feration, maturation, and the myelination of DRG axons.

235 sociated genes in primary sensory neurons of DRG are critical for neuropathic pain genesis.

236 calcium responses of a defined population of DRG neurons to kappaM-RIIIJ.

237 ate a comprehensive translational profile of DRG nociceptors in naive mice and at the peak of neuropa

238 tro and caused defects in axon projection of DRG toward the spinal cord in vivo Furthermore, live-cel

239 ns to the intrinsic electrical properties of DRG neuron subtypes.

240 conditioning-lesion-induced regeneration of DRG neuron central axons is abolished.

241 is required for robust axon regeneration of DRG neurons and behavioral recovery.

242 pain genesis partially through repression of DRG Kcna2 gene expression.

243 es an important means for in vivo studies of DRG functions in sensory perception and disorders.

244 A subpopulation of DRG neurons, prepared from wild-type animals, expressed

245 potential differences in the translatomes of DRG and TG neurons.

246 it from genetic counseling and/or testing of DRGs, which may further inform personalized cancer surve

247 ors abrogated the effect of MET-1 effects on DRG neuron rheobase.

248 , we generate dorsal root ganglia organoids (DRG organoids) by in vitro differentiation of human iPSC

249 rized the expression of TRPC4 in peptidergic DRG neurons and showed that acute itch induced by seroto

250 macrophages, revealing potential peripheral DRG targets for neuropathic pain management.

251 )1.8 sodium channels in incoming presynaptic DRG axons is no longer sufficient to block activation of

252 ng from two classes of colorectal-projecting DRG neuron were identified.

253 that arise from single colorectal-projecting DRG neurons.

254 egeneration, we plated dissociated adult rat DRGs transduced using AAV5-shRNA-fidgetin on a laminin s

255 mice were anesthetized and lumbosacral L6-S1 DRG injected with dextran biotin.

256 After SCI, DRG neurons show hyperactivity and chronic depolarizatio

257 results suggest that clearance of senescent DRG neuronal cells following platinum-based cancer treat

258 that from nonpainful SWN tumors, sensitized DRG neurons, causing increased sensitivity to depolariza

259 ent responses to mechanical stimuli in small DRG neurons of normal healthy mice.

260 ments the mechanical responsiveness of small DRG neurons and potentially sensitizes group IV afferent

261 lated a subset of sensory neurons by sorting DRG neurons back-labeled from paw and thigh muscle.

262 We found that DRG neurons had a plasma membrane tension of approximate

263 Here, we identify that DRG pioneer axons enter the DREZ before the arrival of n

264 ulk and single-cell RNA sequencing show that DRG organoids present a transcriptional signature simila

265 n vivo two-photon calcium imaging shows that DRG neuronal activity is higher in awake than anesthetiz

266 neuropathic pain, our findings suggest that DRG DNMT1 may be a potential target for neuropathic pain

267 in female cortical neurons, suggesting that DRG findings may be generalizable to other nervous syste

268 al density was fairly homogeneous across the DRG length, there was a distinct low density region in t

269 Slack channel expression at the DRG membrane is necessary for their characteristic firin

270 vity of various sensory fiber types from the DRG surface.

271 erlapped with paclitaxel-induced DEGs in the DRG and the DH respectively.

272 the native regulator of CaN 1 (RCAN1) in the DRG at the transcript and protein levels.

273 receptor expressed by satellite glia in the DRG involved in clearing apoptotic neurons during develo

274 the P2X(3) and increased P2X currents in the DRG neurons of PAD rats.

275 inhibitor did not affect the currents in the DRG neurons of TRESK-deficient mice.

276 examine the amplitude of P2X currents in the DRG neurons.

277 ecreased population size (cell death) in the DRG of SIV-infected animals compared with uninfected ani

278 Nociceptors, sensory neurons in the DRG that detect damaging or potentially damaging stimuli

279 expression was upregulated after SNL in the DRG.

280 ociceptive neurons was also increased in the DRG.

281 f inflammatory macrophage recruitment in the DRG.

282 enetrating microelectrodes inserted into the DRG.

283 er, increased macrophage infiltration of the DRG was observed in response to the HFD, absent any pain

284 single-unit activity from the surface of the DRG, although with smaller signal to noise ratios (SNRs)

285 ociceptor biology.SIGNIFICANCE STATEMENT The DRG and trigeminal ganglion (TG) provide sensory informa

286 d 2, T cell-related signaling spreads to the DRG and spinal cord in females, but remains localized to

287 -penetrating arrays were not anchored to the DRG or surrounding tissues, the spike amplitudes did not

288 h ART did not fully ameliorate damage to the DRG, specifically to peptidergic neurons.

289 s induced by application of lidocaine to the DRG, thus pinpointing intermittent failure of spike prop

290 ssion of the purinergic receptor P2X5 in the DRGs.

291 l afferent endings supplied by thoracolumbar DRG.

292 with biotinylated dextran into thoracolumbar DRG (T13-L3).

293 ere, we show that exposure of each opioid to DRG neurons resulted in potentiation of the sustained AS

294 duced CIPN caused macrophage infiltration to DRGs in both sexes, and this infiltration was not affect

295 y preparation approaches and ganglion types [DRG vs trigeminal ganglia (TG)].

296 Using DRG and dorsal horn (DH; another key structure for CIPN

297 When DRG neurons were dialyzed with GRK2i, which sequesters f

298 ith sex differential expression in the whole DRG transcriptome and 66 genes whose messenger RNAs were

299 ession patterns found previously using whole DRG tissue following SNI.

300 ated genes is higher in the TG compared with DRG, whereas several genes associated with the negative