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1 surveyed >3,700 plasma metabolites (50-1,000 Da) for differential expression in XOR wildtype vs. mice
4 1355 Da) and proteins ( approximately 14 000 Da) are demonstrated, with approximately 1-2 orders of m
5 complex that eluted at approximately 151,000 Da upon Superdex 200 size-exclusion chromatography (SEC)
9 l (PEG, molecular weight approximately 8,000 Da, 10(-7)-10(-4) M) increase the half-life of a green f
11 ) with a molecular weight as high as 900 000 Da was successfully detected using the carbon nanofibrou
13 including L4 proteins of 22,000- and 33,000-Da apparent molecular mass (L4-22K and -33K proteins) th
14 n of individual peaks at a spacing of 0.0034 Da at m/z 597 from a complex mixture of Canadian bitumen
21 rocessed heavy chain lysine residues (+128.1 Da), and loss of N-acetylglucosamine (GlcNAc; -203.1 Da)
22 tion post-translational modification (+162.1 Da), partially processed heavy chain lysine residues (+1
24 re isolated for tandem MS analysis using a 1 Da mass isolation window, followed by collision-induced
25 or the 10 LC-MS(2) DDA data sets with > +/-1 Da isolation windows, the median precursor purity score
26 sting a deamidation at a NN motif for a LC+1 Da species, and inconclusive information for a LC+40 Da
28 n II-2 which differed in mass by less than 1 Da, the determination of a sequence for protein IB8a tha
29 nd lipids from 92 selected m/z windows (+/-1 Da) with a spatial resolution of better than 150 mum.
30 r the realization of 16-plex reagents with 1 Da spacing between reporter ions and up to 28-plex at 6
31 spectrometers and a set of 9 reagents with 1 Da spacing between reporter ions for single dalton analy
32 clusters using optimized narrow windows (~10 Da) in scan mode, and standard full scan methods using h
33 low molecular weight ( approximately 30-100 Da) contaminants representative of those detected in wat
34 on is notable both in its size (e.g., at 100 Da, it is one of the larger chemical PTMs) and in its ab
35 served that three molecules ranging from 100 Da to 70 kDa permeated into a preclinical glioblastoma m
39 a for 20 Da wide mass segments across a 1000 Da range, stitched into a single composite mass spectrum
40 permeability at molecular weights above 1000 Da and it appears likely that this cutoff constitutes an
46 However, chemical space from 500 to 1000 Da remains virtually unexplored and represents a vast op
47 another intermediate with a [M-H](-) at 102 Da, identified as ONNHCH(2)NHCHO (NO-NDAB), were detecte
50 t pKpQIL_p019 (p019)-an approximately 11,109-Da protein associated with certain blaKPC-containing pla
51 iaceae spectra found an approximately 11,109-Da signal in nine spectra (1.3%), including seven from p
53 molecules, are shifted by + 4, + 8 and + 12 Da, which expose signals across areas of the previously
54 this, the use of a wide-isolation window (12 Da) to encompass the target analyte and the isotope stan
56 llows a ready overview of metabolites (<1200 Da) and potentially molecular routes to monitor food aut
57 the gas phase, evident from +64 Da and +128 Da signals that can be assigned to Hb carrying two and f
60 depleted human plasma had an additional 1347 Da over the native albumin extracted from human plasma,
61 all model molecules ( approximately 200-1355 Da) and proteins ( approximately 14 000 Da) are demonstr
67 lion molecular structures between 0 and 1450 Da, which correspond to about 27000 distinct elemental f
69 sequencing of oligoporphyrans of up to 1500 Da and included the positioning of the methyl ether and
72 An increase in molecular weight from 1569 Da to 3740 Da resulted in a fivefold decrease in ET tran
74 on reaction pathways: hydroxyl addition (+16 Da), alcoholic oxidation or dehydrogenation (-2 Da), and
76 ns with a peak-to-peak mass difference of 16 Da consistent with the repeating unit of the beta-(1-->3
77 and a mass consistent with ritonavir plus 16 Da, in agreement with the whole-protein mass spectrometr
79 well as a low molecular weight anatoxin (165 Da, 10(-14) m) are detected selectively and reproducibly
80 (110.18 Da) and 4-fluorobenzenethiol (128.17 Da), or large macromolecules such as anti-mouse IgG (~15
81 hallenging, since the mass difference of -17 Da or -18 Da, when formed from Gln or Glu, respectively,
82 ptide FGES198AGAAS with an added mass of 170 Da from cresyl phosphate on serine 198 (Ser198) was dete
83 eights, including small benzenethiol (110.18 Da) and 4-fluorobenzenethiol (128.17 Da), or large macro
84 , since the mass difference of -17 Da or -18 Da, when formed from Gln or Glu, respectively, is not un
85 ides, dyes, drugs, lipids, and proteins (186 Da to 8.5 kDa) from various materials including urine, b
87 tic neutral loss pattern of 98, 178, and 196 Da, which enables the distinction between isobaric pyro-
90 isomers formed single unique [M + H](+) (199 Da) parent ions, whereas in MALDI each isomer shows sign
95 idation product with the loss of hydrogen (2 Da mass decrease) for Trp-107 of the heavy chain was ide
97 h (18)O at isoAsp leads to a mass shift of 2 Da, which can be automatically and unambiguously recogni
98 repeatedly cycles through 28 consecutive 20 Da precursor isolation windows detecting all precursor i
99 anic asphalt sample by acquiring data for 20 Da wide mass segments across a 1000 Da range, stitched i
100 cover a range of MWs (25 000-50 000 vs <200 Da) as well as carboxyl content (polygalacturonic acid (
103 molecular weight cutoff (MWCO) of 1000-2000 Da but also have a high pure water permeability (PWP) of
105 seful for analysis of small molecules (<2000 Da) such as those present in petroleum crude oil and pet
106 ting equipment, a large search space of 2000 Da was constructed, and assignment performance was evalu
109 docyanine green (ICG) conjugated with a 2100 Da PEG molecule (ICG-PEG45) as a renal-tubule-secreted n
111 boxylic acids with molecular weight (MW) 216 Da (most likely C10H16O5) and MW 214 Da (C10H14O5) was c
114 an increase in mass of the apo-CYP2B4 by 218 Da as determined by electrospray ionization liquid chrom
115 ALDI-TOF revealed a molecular mass of 13,221 Da, and 12-23 aa sequences of OIF had homology with huma
116 ith a relatively small molecular weight (221 Da), provides an optimal building block for developing a
117 ducing compound has an estimated mass of 226 Da, as determined by mass spectrometry, and is referred
118 of bisphenol A, a low molecular weight (228 Da) target usually detectable only by indirect detection
119 Neutral loss (NL of 176, 194, 211, and 229 Da) and precursor ion (PI of m/z 141, 159, and 177, in p
123 provides a diagnostic mass difference of 24 Da and enables differentiation of double-bond positional
126 orm to detect ultralow-molecular-weight (244 Da) biomolecules at picomolar concentrations using a sta
131 eight hyaluronan (LMW-HA, approximately 2500 Da) promotes endothelial cell (EC) barrier disruption an
132 of 0.50 nm, a molecular weight cutoff of 255 Da, and a reasonably high pure water permeability (A) of
135 5 Da), retrorsine (351 Da), and estrone (270 Da), to demonstrate some important aspects of the workfl
136 educing the size of this analog by about 274 Da resulted in the resumption of the transport activity
137 ic and multimeric, ranging in mass from 2846 Da (melittin) to 150 kDa (Immunoglobulin G), and we cons
138 the loss of the GlcNAcPHN unit (311 and 295 Da), and fucose cleavage followed the loss of the chitob
139 de ions have masses ranging from 231 to 2969 Da, Omega(He) of 89-616 A(2), and Omega(N(2)) of 151-801
141 confirmed the protein mass and revealed a 30 Da mass difference between proteins from the two species
143 limit of EcChiP to be approximately 200-300 Da for small permeants that pass through by general diff
147 high pressures associated with using the 300-Da membrane, calibration in this small size range, accou
154 ctra (SWATH), which uses Q1 windows of 20-35 Da for data-independent fragmentation, was systematicall
157 cryptospirolepine (505 Da), retrorsine (351 Da), and estrone (270 Da), to demonstrate some important
159 f ca. 1.8 S and a molecular weight of 14 363 Da were determined for HD5(ox) at pH 7.0, supporting a t
161 ase in molecular weight from 1569 Da to 3740 Da resulted in a fivefold decrease in ET transfer for ra
162 BBB permeability of sodium fluorescein (376 Da), Alexa Fluor (643 Da), and fluorescent albumin (45 k
163 olecules (molecular weight approximately 380 Da) that compete with the peptide docking motif for bind
164 g a 62-nucleotide (molecular weight = 20,395 Da) RNA-based aptamer, highly specific to the human IL-2
166 tural diversity, which ranges from the 803.4 Da thalassospiramide C to the 1291.7 Da thalassospiramid
172 olar and higher molecular weight (HMW; > 400 Da) components abundant in crude and heavy fuel oils (HF
173 he inhibitors possess molecular weights <400 Da, log D(7.4) < 2.5, topological polar surface area < 7
174 o detect low molecular weight (less than 400 Da) chemical and biological analytes under extremely dil
175 from more recent lots are roughly 200 to 400 Da lower than initial measurements made in the early 199
178 of 100% for six proteins (MW 8759 to 68 425 Da), 96-98% for five proteins (MW 11 458 to 36 431 Da),
179 92% for three proteins (MW 15 971 to 36 431 Da), 80-87% for four proteins (MW 42 287 to 162 134 Da),
180 6-98% for five proteins (MW 11 458 to 36 431 Da), 92% for three proteins (MW 15 971 to 36 431 Da), 80
182 tion of diagnostic neutral molecules CO2 (44 Da) and C2H6O2Si (90 Da) for aromatic carboxylic acids.
184 h-molecular weight (molecular weight of >450 Da) products were observed under dry conditions with ind
185 d systematic iron coagulation of large (>450 Da), oxygen-rich, and highly aromatic DOM molecules of t
186 he development of low molecular weight (<450 Da) and nonpeptidic, single-digit micromolar mechanism-b
187 f 40 poly(8:2 FTAC-co-HDA) signals (911-4612 Da) were normalized to the signal intensity of a matrix-
190 d glycopeptides, producing an abundant Y1-48 Da ion instead (the nominal mass difference is given rel
192 ces two labeled peak clusters separated by 5 Da in MS(1) spectra that are detected as five isotopic p
195 ge, but in this work, membranes with 100-500 Da MWCO were evaluated for feasibility in concentrating
196 ely wide range of molecular weights (150-500 Da), polarities, and structural diversity were selected
198 wed concentration of the 300-400 and 400-500 Da molecular weight range peptides in the KCl-F1 and KCl
199 of peptides with molecular weights above 500 Da are needed to identify parameters that influence oral
200 ecular weight (typically < approximately 500 Da) drugs can effectively permeate through intact stratu
201 rity of absorption was due to molecules >500 Da, and these contributed an increasing fraction of abso
202 occus pyogenes Cas9 (SpCas9) that weigh <500 Da and are cell permeable, reversible, and stable under
203 he detection of lower-molecular-weight (<500 Da) biomolecules in highly diluted solutions is still a
204 low background in the low mass region (<500 Da), contrary to citrate stabilized AuNPs (citrate-AuNPs
208 thetically feasible organic molecules of 500 Da molecular weight or less, is estimated to contain ove
210 gether with the small molecular weight (~500 Da), the water solubility, the ease of functionalization
211 ple compounds, namely cryptospirolepine (505 Da), retrorsine (351 Da), and estrone (270 Da), to demon
212 and had a molecular mass between 375 and 525 Da, which was 150 to 200 Da higher than for an average D
216 re detected, including acetylation and a +57 Da species that could be the addition of a glyoxal moiet
219 he ratios of doublet signals with a static 6 Da mass difference in MALDI-MS and the change in relativ
220 e-C47 product (molecular weight: 7.3 x 10(6) Da) was composed of the following monosaccharides: gluco
221 ed glycerol clusters ( greater, similar10(6) Da, greater, similar +/- 100 charges) have been used to
222 accharide with molecular weight of 1.35x10(6)Da and a specific optical rotation of +64 degrees (c 1.0
223 ecular masses of more than approximately 600 Da is thought to be mediated by TonB-dependent, active t
225 tic WEOM molecules that are greater than 600 Da and the reduced binding force of orthophosphate to WE
229 nsition into the gas phase, evident from +64 Da and +128 Da signals that can be assigned to Hb carryi
233 exploits either generation of a signature 69 Da ion from Ile or formation of unique w-ions employing
234 l, co-oligomers with molar masses up to 6901 Da, ultralow molar mass dispersities (D </= 1.00002), an
235 e 803.4 Da thalassospiramide C to the 1291.7 Da thalassospiramide F, results from a complex sequence
238 les of intermediate size (approximately 7000 Da), which possess both the targeting and effector funct
240 tal ion current) chromatograms, using the 74 Da fragment ion, which originated from McLafferty rearra
243 l protein containing 71 amino acids (MW 7821 Da) with a reported analgesic potency greater than morph
249 This analysis revealed that PAHs of 239-838 Da, containing few oxygenated species, comprise the soot
250 ealed the binding modes of these large (~850 Da) compounds in detail and explained the observed SAR,
252 r large biomolecules such as ubiquitin (8565 Da), the amino acid sequence coverage increases from 39%
253 loss of 2-fluoro-1,3,2-dioxaborale (MW of 88 Da) only in the case of deprotonated, migrated acyl-gluc
256 gh molecular mass (e.g., between 400 and 900 Da) to less than 10 and in some cases, it was possible t
259 it is confirmed that fennel nsLTP1 is a 9433 Da single polypeptide chain consisting of 91 amino acids
261 ing studies, we also demonstrate that the 98 Da neutral loss occurs via gas-phase phosphoryl transfer
262 ly we show that mammalian homologs of Ey and Da can functionally replace their Drosophila counterpart
264 ristic Df approximately 2.6, Dm > 1 mum, and Da </= 300 nm that form via the cluster-dense aggregatio
265 ic Health of the People's Republic of China, Da Qing First Hospital, China-Japan Friendship Hospital,
266 on characteristic image parameters: Daisne (Da) modified, based on signal-to-background ratio; Nestl
267 we show that a linked dimer of Daughterless (Da), the only Drosophila class I bHLH protein, activates
269 T2h, the complex T2h with HIE had decreased Da, increased De, perpendicular in both premyelination a
272 extra-axonal axial and radial diffusivities (Da, De,// and De, perpendicular), to compare WM differen
273 mc lacks a basic DNA-binding domain, the Emc-Da heterodimer cannot bind to and regulate genomic targe
274 d by measuring dialyzable mineral fraction (%Da) resulting from in vitro gastrointestinal digestion.
276 d bromide in sediments containing 8-18% gas (Da,YE) were suppressed by 7-39% compared to the control
277 rexpression of each single orthologous gene (Da, Mef2, Ube3a, Zfh1, XNP) and in pairwise combinations
280 perpendicular, but no significant change in Da in multiple premyelination regions, indicative of exp
281 ial, started in 1986, in which 33 clinics in Da Qing, China, were randomly assigned to either be a co
282 ster randomised trial in which 33 clinics in Da Qing, China-serving 577 adults with impaired glucose
295 Whereas gas voids in sediments reduce the Da for soluble species, they represent a shortcut for lo
296 pneumonia (per clinician assessment) to the Da Nang Hospital for Women and Children were prospective
297 41 resident physicians performing the Tubes (Da Vinci Intuitive Surgical, Sunnyvale, CA) simulator ex
299 rocheate (Emc), which forms heterodimer with Da, antagonizes the synergistic activation from Da but n