ライフサイエンスコーパス: Diels

1 Diels-Alder cyclization of diverse diene-dienophile reac

2 Diels-Alder reaction occurs via a concerted mechanism if

3 ing advantage of the decarbonylative [4 + 2] Diels-Alder cycloaddition reaction between ethynyl and t

4 tone, which may proceed as a concerted [4+2] Diels-Alder reaction or a stepwise [6+4] cycloaddition f

5 The reaction process involves [4+2] Diels-Alder, retro-Diels-Alder, and 1-1' coupling reacti

6 hat undergoes a wide range of reactions as a Diels-Alder diene, dienophile, and [2 + 2] addend.

7 lallene exhibits exceptional reactivity as a Diels-Alder reaction partner and engages in [4 + 2] cycl

8 ggests that the enzyme SpnF does behave as a Diels-Alderase.

9 uct of which is immediately intercepted by a Diels-Alder cycloaddition.

10 ce of a natural enzyme evolved to catalyze a Diels-Alder reaction and shows how catalysis is achieved

11 key features of our route are as follows: a Diels-Alder reaction of masked o-benzoquinone to assembl

12 transfer of stereochemical information in a Diels-Alder cycloaddition through a point-chirality, axi

13 tions quantitatively reproduce the KIEs in a Diels-Alder reaction and a catalytic glycosylation.

14 he presence of light with suitable enes in a Diels-Alder reaction and undergoes a transformation into

15 en steric size and diastereoselectivity in a Diels-Alder reaction.

16 trolled by force-dependent dissociation of a Diels-Alder adduct of anthracene and maleimide.

17 tance and increased biological activity of a Diels-Alder cyclized (DAC) RGD peptide.

18 analogs was synthesized using as key steps a Diels-Alder reaction to generate a highly substituted bi

19 lene were successfully synthesized through a Diels-Alder/oxidative cyclodehydrogenation approach.

20 e C70 derivative were synthesized by using a Diels-Alder cycloaddition followed by an addition-elimin

21 nthesis of 2,2'-bis(naphthoquinones) using a Diels-Alder reaction of conjugated ketene silyl acetals

22 rgoes post-assembly modification (PAM) via a Diels-Alder cycloaddition of the anthracene panels of th

23 This reaction sequence proceeds via a Diels-Alder cycloaddition reaction catalyzed by dimethyl

24 en participate in a second stage acylnitroso Diels-Alder cycloaddition.

25 ne dinucleotide-dependent enzyme, Morus alba Diels-Alderase (MaDA), from Morus cell cultures, that ca

26 abolites, no naturally occurring stand-alone Diels-Alderase has been demonstrated to catalyse intermo

27 as achieved via an intramolecular amidofuran Diels-Alder cycloaddition/rearrangement followed by an i

28 gonucleotides employing Michael addition and Diels-Alder cycloaddition reactions.

29 based on the 1,3-dipolar cycloadditions and Diels-Alder reactions owing to their excellent reaction

30 echanisms of various electrocyclizations and Diels-Alder reactions.

31 een the recently proposed bis-pericyclic and Diels-Alder routes is blurred, and favorable transition

32 Solid-phase chemistry for the synthesis and Diels-Alder reaction of Fmoc-protected azopeptides has b

33 The reactions proceed via an aryne Diels-Alder (ADA) reaction, followed by a facile aromati

34 cycloalkylidenecarbenes, were intercepted as Diels-Alder adducts.

35 anocatalyst for iminium-ion-based asymmetric Diels-Alder reactions following a rational design approa

36 two recently developed catalytic asymmetric Diels-Alder (DA) reactions of cinnamate esters with cycl

37 the polyol chain, a Ti-catalyzed asymmetric Diels-Alder reaction to generate the cis-decalin skeleto

38 The thermal 6pai aza-Diels-Alder cycloadditions between alpha-oxoketenes, in

39 Thermal asymmetric aza-Diels-Alder reactions also proceeded in good yields and

40 theoretical study of the intermolecular Aza-Diels-Alder reaction using 5-aminopyrrole as a building

41 ernal electric fields (EEFs) on the same aza-Diels-Alder reaction, demonstrating that very strong EEF

42 The mechanism of the aza-Diels-Alder reaction catalyzed by tetraalkylammonium or

43 The aza-Diels-Alder reaction of various alkenes and in situ form

44 photoredox catalysis of radical cation based Diels-Alder cycloadditions mediated by the first-row tra

45 est is retained, as evidenced in a benchmark Diels-Alder reaction.

46 es yields several three-dimensional bicyclic Diels-Alder adducts.

47 A key biomimetic Diels-Alder dimerization was found to occur at ambient t

48 with two ester substituents were prepared by Diels-Alder cycloadditions of cyclopentadiene with dimet

49 ific modifications, cyclizations promoted by Diels-Alderases, and acetylation-elimination reactions.

50 luable for the fusion of additional rings by Diels-Alder reactions.

51 te that cucurbit[7]uril (CB[7]) can catalyse Diels-Alder reactions for a number of substituted and un

52 1.9 kcal mol(-1)) and identify the catalytic Diels-Alder proficiencies (>80% accuracy) of two homolog

53 cture a perfect molecular vessel to catalyze Diels-Alder reactions of 9-hydroxymethylanthracene with

54 ms of recently reported Lewis acid-catalyzed Diels-Alder reactions of arylallenes and acrylates were

55 The lithium cation Li(+)-catalyzed Diels-Alder (DA) reactions of benzene toward a series of

56 representative photocatalytic radical cation Diels-Alder reaction.

57 on pathway suggest that a stepwise, cationic Diels-Alder cycloaddition is operative.

58 In the classic Diels-Alder [4 + 2] cycloaddition reaction, the overall

59 For example, in the classic Diels-Alder reaction, butadiene and ethylene combine to

60 15COC identical withCR) for use in classical Diels-Alder (DA) reactions (with 1,3-cyclopentadiene).

61 reaction flow in water, while the classical Diels-Alder mechanism contributes only approximately 17%

62 rgy barrier of 22 kcal/mol for the concerted Diels-Alder process and provide no evidence of a competi

63 , such as maleimides, through a conventional Diels-Alder reaction.

64 s inspired the development of a Claisen/Cope/Diels-Alder cascade reaction.

65 o synthetic gain in a cascade cross-coupling/Diels-Alder reaction, delivering borylated or non-boryla

66 reactions as 2pi or 4pi components (covering Diels-Alder and 1,3-dipolar cycloadditions).

67 [4+2] cycloadditions (Diels-Alder reactions) have been widely used in organic

68 f hydromorphone by oxidative dearomatization/Diels-Alder cycloaddition was investigated.

69 eory (M06-2X) studies of a series of dehydro-Diels-Alder (DDA) reactions.

70 essfully prepared by using the photo-dehydro-Diels-Alder (DDA) reaction, access to (1,7)naphthalenoph

71 The emerging inverse electron demand Diels-Alder (IEDDA) reaction stands out from other bioor

72 ently engaged in the inverse electron demand Diels-Alder (iEDDA) reaction with cyclooctyne.

73 sent work reports an inverse electron demand Diels-Alder (iEDDA)-type reaction to synthesize 1,3,5-tr

74 gged protein through inverse electron demand Diels-Alder cycloaddition with subsequent double retro-D

75 Inverse-electron demand Diels-Alder cycloadditions have emerged as important bio

76 gy predicated on the inverse electron demand Diels-Alder reaction as well as the use of this approach

77 aminothiols and the inverse-electron demand Diels-Alder reaction between tetrazine and trans-cyclooc

78 applications of the inverse electron demand Diels-Alder reaction is provided that have been conducte

79 Inverse electron demand Diels-Alder reactions between s-tetrazines and strained

80 nts of bioorthogonal inverse-electron demand Diels-Alder reactions involving 1,2,4,5-tetrazines deriv

81 to catalysis of the inverse electron demand Diels-Alder reactions of heterocyclic azadienes has been

82 nent of well-behaved inverse electron demand Diels-Alder reactions where it preferentially reacts wit

83 ng fast and selective normal electron-demand Diels-Alder (DA) reactions following its incorporation i

84 However, the inverse electron-demand Diels-Alder (DAinv) reaction between tetrazine (Tz) and

85 oaddition (SPAAC) or inverse-electron-demand Diels-Alder (IE-DA) reactions.

86 The bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) cleavage reaction between tetrazine

87 The inverse electron-demand Diels-Alder (IEDDA) cycloaddition, which was performed o

88 gent via a no-rinse, inverse electron-demand Diels-Alder (IEDDA) reaction, enabling their immediate v

89 and strain-promoted inverse electron-demand Diels-Alder cycloaddition (SPIEDAC) targeted to cyclopro

90 the strain-promoted inverse electron-demand Diels-Alder cycloaddition, that is, tetrazine ligation,

91 ugh an intracellular inverse-electron-demand Diels-Alder reaction with a suitable dienophile.

92 id and bioorthogonal inverse electron-demand Diels-Alder reaction.

93 a proline-catalyzed inverse-electron-demand Diels-Alder reaction.

94 zines by means of an inverse-electron-demand Diels-Alder reaction.

95 tepwise mechanism of inverse electron-demand Diels-Alder reactions of 1,2,3-triazines, and that these

96 ave investigated the inverse electron-demand Diels-Alder reactions of trans-cyclooctene (TCO) and end

97 These inverse electron-demand Diels-Alder reactions of triazines have wide application

98 lopentadiene and the inverse electron-demand Diels-Alder reactions with 3,6-bis(trifluoromethyl)tetra

99 The normal electron-demand Diels-Alder reactions with cyclopentadiene and the inver

100 yclopropenes in an inverse electronic demand Diels-Alder (IEDDA) cycloaddition-cycloreversion sequenc

101 ond, substrate-controlled diastereoselective Diels-Alder reaction with a different dienophile to form

102 A is described employing diastereoselective Diels-Alder and selenocyclization reactions, starting fr

103 1,2-DHPs, followed by the diastereoselective Diels-Alder reaction with N-aryl maleimides furnishing i

104 ed rings, the un-rearranged dibenzothiophene Diels-Alder adduct is isolated in every instance.

105 , biomimetic total synthesis of the dimeric, Diels-Alder natural product griffipavixanthone from a re

106 ydrobenzo[m]tetraphene, by means of a double Diels-Alder reaction between styrene and a versatile ben

107 We further report that double Diels-Alder reactions under solvent-free condition provi

108 We demonstrate a C-F bond driven Diels-Alder reaction of a fluorinated dienophile and a b

109 nthetic sequence features a highly effective Diels-Alder reaction using a carbamate-substituted silox

110 lysts capable of unlocking new and efficient Diels-Alder reactions would have major impact.

111 ough this study is a highly enantioselective Diels-Alder reaction of a versatile cyclic carbamate sil

112 tionalize the origin of the enantioselective Diels-Alder reaction (DA) of o-hydroxystyrene and azlact

113 These data establish Diels-Alder cyclization as a versatile approach to stabi

114 Few examples of oximino ether Diels-Alder reactions have been reported previously, and

115 celerate disfavored enolate addition and exo Diels-Alder reactions enantioselectively.

116 ridge in one step, and a stereoselective exo-Diels-Alder reaction to form the 6-membered ring.

117 A first Diels-Alder condensation followed by a Stille cross-coup

118 Asymmetric syntheses of the flavonoid Diels-Alder natural products sanggenons C and O have bee

119 ligation system, affording a pro-fluorescent Diels-Alder product that, on demand, converts into an in

120 Yamamoto-type cyclization followed by 6-fold Diels-Alder cycloaddition, C216 was obtained by oxidativ

121 Outcomes are exemplified for Diels-Alder cycloadditions, oxidative addition of bonds

122 -switchable electrostatic organocatalyst for Diels-Alder reactions.

123 from 1 to 2,3-dimethyl-1,3-butadiene to form Diels-Alder product 3 with a zero-order dependence on di

124 ediates subsequently undergo either a formal Diels-Alder cycloaddition or a competitive Michael addit

125 ation-dimerization sequence to afford formal Diels-Alder adducts that undergo a smooth gold-catalyzed

126 sight into enantioselective enzymatic formal Diels-Alder reactions.

127 ganic polymer (3D p-POP) using catalyst-free Diels-Alder cycloaddition polymerization followed by aci

128 x-membered rings are readily accessible from Diels-Alder reactions, cycloadditions that generate five

129 ic, enantioselective prototropic shift/furan Diels-Alder (IMDAF) cascade to construct the ACD tricycl

130 II)-catalyzed formation of asymmetric hetero Diels-Alder adducts.

131 oevenagel condensation/intramolecular hetero Diels-Alder reaction using O-(arylpropynyloxy)-salicylal

132 s likely arise from an intramolecular hetero Diels-Alder reaction.

133 -membered phosphorus heterocycles via hetero Diels-Alder reactions.

134 culminates in an intramolecular [4+2] hetero-Diels-Alder (IMDA) cyclization to furnish the bicyclo[2.

135 f aziridines and alkenes, and [4 + 2] hetero-Diels-Alder cycloaddition of aldehydes with dienes.

136 uent spontaneous intramolecular [4+2] hetero-Diels-Alder cycloaddition.

137 The domino aldol/hetero-Diels-Alder synthesis of some new tricyclic pyrano[3,4-c

138 intramolecular Diels-Alder (IMDA) and hetero-Diels-Alder (HDA) cyclizations from an ambimodal transit

139 tions: intramolecular Diels-Alder and hetero-Diels-Alder reactions via a single ambimodal transition

140 azadiene in metal-free base-assisted hetero-Diels-Alder reaction is exploited to quickly assemble an

141 y regioselective, ytterbium-catalyzed hetero-Diels-Alder reaction of enones with vinyl ethers followe

142 prepared by two and three consecutive hetero-Diels-Alder reactions (or conjugated additions) between

143 sing a tandem inverse-electron-demand hetero-Diels-Alder/oxa-Michael reaction catalyzed by modularly

144 gate addition inverse-electron-demand hetero-Diels-Alder/retro-Diels-Alder ( ihDA/ rDA) reaction, was

145 onal urea-catalyzed asymmetric direct hetero-Diels-Alder reaction between alkylidene azlactone-derive

146 The direct hetero-Diels-Alder reaction followed by ring opening results in

147 This intramolecular hetero-Diels-Alder reaction features unactivated dienophiles an

148 and isobruceol was an intramolecular hetero-Diels-Alder reaction of an o-quinone methide that was fo

149 fic functional end group, by means of hetero-Diels-Alder cycloaddition through their inherent termina

150 an oxa-6pi electrocyclic ring-opening/hetero-Diels-Alder pericyclic cascade.

151 arylnitroso compounds using a one-pot hetero-Diels-Alder/ring contraction sequence.

152 followed by a highly stereocontrolled hetero-Diels-Alder reaction.

153 he second catalyses a stereoselective hetero-Diels-Alder reaction.

154 The reaction proceeds via a tandem hetero-Diels-Alder cycloaddition of N,N'-bis(benzenesulfonyl)su

155 ective Bronsted acid catalysts of the hetero-Diels-Alder reaction of a wide variety of aldehydes and

156 ding the asymmetric induction for the hetero-Diels-Alder reaction.

157 e periselectivities from Alder-ene to hetero-Diels-Alder and vice versa.

158 tion of alpha- and beta-lapachone via hetero-Diels-Alder reactions was investigated by experimental a

159 Hoye reported intramolecular hexadehydro-Diels-Alder (HDDA) reactions to generate arynes that fun

160 ree steps by capitalizing on the hexadehydro-Diels-Alder (HDDA) cycloisomerization reaction in which

161 ere experiments showing that the hexadehydro-Diels-Alder (HDDA) cycloisomerization reaction proceeds

162 We demonstrate that the hexadehydro-Diels-Alder (HDDA) cycloisomerization reaction to produc

163 ubstrates typically used for the hexadehydro-Diels-Alder (HDDA) cycloisomerization reactions that pro

164 zynes thermally generated by the hexadehydro-Diels-Alder (HDDA) cycloisomerization.

165 Here we report the use of the hexadehydro-Diels-Alder (HDDA) reaction for the de novo construction

166 ow that benzynes produced by the hexadehydro-Diels-Alder (HDDA) reaction react with many secondary me

167 l aryl triflate) and the thermal hexadehydro-Diels-Alder (HDDA) reaction.

168 n starts with the Rh-catalyzed stepwise homo Diels-Alder cyclisation of NBD into its exo-cis-endo dim

169 mercially available arylsulfonyl cyanides in Diels-Alder cycloadditions to generate isopyridine cyclo

170 e, and their 1-aza- and 2-aza-derivatives in Diels-Alder reactions with ethylene and fumaronitrile we

171 electrophilic substitution and as dienes in Diels-Alder cycloaddition.

172 y of the various dienes for both the initial Diels-Alder reaction and a possible, subsequent ene reac

173 azaoctane structures using an intermolecular Diels-Alder cycloaddition between a pyrazinone and comme

174 been demonstrated to catalyse intermolecular Diels-Alder transformations.

175 oothly undergo either in situ intermolecular Diels-Alder reactions to deliver highly functionalized/s

176 A stereoselective intermolecular Diels-Alder cycloaddition of an intermediate pyrazinone

177 An intramolecular Diels-Alder reaction and an enone-olefin cycloaddition/f

178 By taking advantage of an intramolecular Diels-Alder reaction, we have developed a prodrug strate

179 ohydrate-templated asymmetric intramolecular Diels-Alder reaction of a masked o-benzoquinone (MOB) 9

180 that can undergo bifurcating intramolecular Diels-Alder (IMDA) and hetero-Diels-Alder (HDA) cyclizat

181 ding a chiral amine-catalyzed intramolecular Diels-Alder reaction to afford 22 in excellent diastereo

182 nd several Lewis acid induced intramolecular Diels-Alder reactions remained fruitless, dialkylaluminu

183 tion leading to a spontaneous intramolecular Diels-Alder reaction.

184 was completed by a late-stage intramolecular Diels-Alder furan (IMDAF) cycloaddition to install the i

185 (2) a highly stereoselective intramolecular Diels-Alder (IMDA) reaction of the camphanate-containing

186 dimerization cascade and the intramolecular Diels-Alder cascade.

187 An approach to the intramolecular Diels-Alder reaction has led to a cascade synthesis of c

188 variety of parameters on the intramolecular Diels-Alder reaction was investigated, including diene a

189 sting enzymatic examples (the intramolecular Diels-Alder reaction, and the Cope and the Claisen rearr

190 e pericyclic transformations: intramolecular Diels-Alder and hetero-Diels-Alder reactions via a singl

191 Nitrofurans undergo intramolecular Diels-Alder reactions with tethered electron-poor dienop

192 uct distributions of expected and isomerized Diels-Alder adducts.

193 is of wickerol A (1) that is based on a Jung Diels-Alder reaction, an intramolecular alkylation to co

194 byA5, implicated in the formation of the key Diels-Alder substrate to give the spirocyclic system of

195 NH4OAc mediated domino Knoevenagel/Diels-Alder cyclocondensation of beta-ketosulfones 1 and

196 dipoles), and [4 + 2] cycloadditions (mainly Diels-Alder-type reactions).

197 hanochemical activation of a furan-maleimide Diels-Alder adduct reveals a latent furfuryl carbonate t

198 vel of orthogonality, namely furan/maleimide Diels-Alder chemistry.

199 nic species which can be used to effect many Diels-Alder reactions in >95% yield and >95% ee using ca

200 As a key-step, a chiral auxiliary-mediated Diels-Alder cycloaddition was developed, introducing the

201 dihydrocatechol in inter- or intra-molecular Diels-Alder reactions.

202 by mimicking the mode of action of a natural Diels-Alderase.

203 enzyme shown here to be a bona fide natural Diels-Alderase.

204 on of product inhibition observed in natural Diels-Alderase enzymes, and pave the way toward the deve

205 s developed, which depended on the extent of Diels-Alder (DA) reaction of bismaleimide with furan.

206 Despite the importance of Diels-Alder reactions in the biosynthesis of numerous se

207 The mechanisms of Diels-Alder reactions between 1,2,3-triazines and enamin

208 alumina, stabilizes and separates a pair of Diels-Alder reagents.

209 include an enantioselective organocatalytic Diels-Alder reaction to construct the C ring, a diastere

210 tereo-, and enantioselective organocatalyzed Diels-Alder reactions with acrolein to form enantiomeric

211 yabeacin analogues is derived via cross-over Diels-Alder reactions from pools of ortho-quinol precurs

212 The method involves an initial oxa-Diels-Alder reaction of ortho-quinone methides generated

213 are presumably formed through an initial oxa-Diels-Alder reaction, followed by an elimination of amin

214 ein, featuring an unprecedented oxopyrrolium Diels-Alder cycloaddition which furnishes a key tetracyc

215 r pericyclic reactions, including the parent Diels-Alder cycloaddition of butadiene with ethylene, el

216 ew cycloisomerization process a pentadehydro-Diels-Alder (PDDA) reaction-a nomenclature chosen for ch

217 Specifically, we exploit the photo-Diels-Alder reaction of triazolinediones with naphthalen

218 rmed through an intramolecular photochemical Diels-Alder reaction.

219 rring the catalytic architecture of possible Diels-Alderases.

220 The key step consists of the one-pot Diels-Alder trapping of a reactive 2-aminofuran intermed

221 roquinones in unprotected form via a one-pot Diels-Alder/ring-opening/tautomerization sequence.

222 xt]-cyclases have been reported as potential Diels-Alderases; however, whether their catalytic cycles

223 An intramolecular strain-promoted Diels-Alder methylenecyclopropane (IMDAMC) reaction prov

224 degree of oxidation of naphthazarin quinone Diels-Alder adduct 10 is additionally demonstrated and e

225 ver-mediated [3,3]-sigmatropic rearrangement/Diels-Alder reaction of 1,9-dien-4-yne esters is describ

226 as a bifunctional NADPH-dependent reductase/Diels-Alderase.

227 d, in which the key step is a regioselective Diels-Alder reaction between a pyranobenzoquinone dienop

228 orated endo stereochemistry of the resulting Diels-Alder adduct, and confirmed that the unique archit

229 al conditions, these adducts undergo a retro Diels-Alder reaction and we use our temperature dependen

230 formed spontaneously decomposes via a retro-Diels-Alder (rDA) reaction to afford a beta-substituted

231 imination of bromo-ethylmalonate and a retro-Diels-Alder cycloaddition reaction.

232 istry on the rate of force-accelerated retro-Diels-Alder reactions of furan/maleimide adducts.

233 on process involves [4+2] Diels-Alder, retro-Diels-Alder, and 1-1' coupling reactions, and the former

234 rse-electron-demand hetero-Diels-Alder/retro-Diels-Alder ( ihDA/ rDA) reaction, was achieved using th

235 eactions occur, namely two Diels-Alder/retro-Diels-Alder sequences, which can be performed in a stepw

236 e small-molecule cargo was achieved by retro-Diels-Alder cleavage of an oxanorbornadiene linkage, pre

237 .C(2)H(4) results in the corresponding retro-Diels-Alder reaction, establishing DPF as a molecule tha

238 r cycloaddition with subsequent double retro-Diels-Alder reactions to form a stable pyrrole linkage.

239 e formation, disulfide formation, reversible Diels-Alder reactions), and (iii) physical cross-linking

240 Sequential Diels-Alder reactions on a tautomerized naphthazarin cor

241 Upon tandem Diels-Alder reactions with several symmetrical as well a

242 lude a 1,3-dioxa-2-silacyclohexene templated Diels-Alder cycloaddition and type-3 semipinacol rearran

243 Here we demonstrate that Diels-Alder [4 + 2] cycloadditions can be harnessed for

244 The Diels-Alder chemistry of these new dendralenes (as multi

245 The Diels-Alder reaction between 1 and 6 occurs under the se

246 The Diels-Alder reaction enables introduction of new functio

247 The Diels-Alder reaction is a cornerstone of modern organic

248 The Diels-Alder reaction is one of the most common methods t

249 The Diels-Alder reaction is one of the most powerful and wid

250 The Diels-Alder reaction of the photocaged diene (o-quinodim

251 The Diels-Alder reactions between 2 equiv of (E,E)-1,4-bis(4

252 The Diels-Alder reactions of 2-(1'-cycloalkenyl)thiophenes a

253 The Diels-Alder reactivities of a series of cycloalkenes, fr

254 The Diels-Alder reactivity of C59NH azafullerene has been ex

255 The Diels-Alder substrate is built up in an efficient manner

256 a ring-closing metathesis reaction, and the Diels-Alder cycloaddition of a dienol acetate.

257 rene and 2,2,2-trifluoroacetophenone and the Diels-Alder reaction of cyclopentadiene with methyl viny

258 2 cycloadduct under kinetic control, but the Diels-Alder cycloadduct is formed under thermodynamic co

259 Both are produced by the Diels-Alder condensation of hexachlorocyclopentadiene wi

260 rbaldehyde motif that is inaccessible by the Diels-Alder cycloaddition.

261 To this end, the Diels-Alder cycloaddition reaction involving cyclopentad

262 Rolf Huisgen explored the Diels-Alder reactions of 1,3,5-cycloheptatriene (CHT) an

263 an-containing CPP precursor was used for the Diels-Alder reaction with the parent benzyne or 3,6-dime

264 The activation free energies for the Diels-Alder reactions of cyclic 1-azadienes are 10-14 kc

265 The physical factors governing the Diels-Alder reactivity of (2,7)pyrenophanes have been co

266 diene moiety of DPF is a potent diene in the Diels-Alder reaction and reacts with dienophiles dimethy

267 The origins of chirality transfer in the Diels-Alder reaction using chiral arylallenes are uncove

268 equivalents for application as dienes in the Diels-Alder reaction.

269 with the distortion of the reactants in the Diels-Alder reactions are nearly identical and that the

270 reactivities and stereoselectivities in the Diels-Alder reactions of substituted cyclopropenes with

271 currently proposed mechanisms (including the Diels-Alder one) for this reaction in water (as a first-

272 The key steps involve the Diels-Alder cycloaddition of cyclopent-2-en-1-one to the

273 ed with the gas phase, the enzyme lowers the Diels-Alder barrier significantly, consistent with exper

274 tionally analyze the regioselectivity of the Diels-Alder (DA) reaction of cyclopentadiene to the holl

275 Manipulation of the Diels-Alder adducts provides the desired geometrically d

276 he subsequent reductive deoxygenation of the Diels-Alder adducts with Fe2(CO)9 followed by oxidative

277 asymmetric Lewis-acid organocatalysis of the Diels-Alder cycloaddition of cyclopentadiene to cinnamat

278 A case study of the Diels-Alder cycloaddition of cyclopentadiene with ethyle

279 ar correlation between the logarithms of the Diels-Alder rate constants and measured K(1:1) values.

280 ibutes to the enhancement of the rate of the Diels-Alder reaction.

281 e reactivity and endo/exo selectivity of the Diels-Alder reactions involving 1,2-azaborines have been

282 Third, the superoxide species reduces the Diels-Alder cycloadduct radical cation to the final prod

283 d with free energy simulations show that the Diels-Alder pathway is favored in the enzyme environment

284 It is observed that the Diels-Alder reaction only displays high diastereoselecti

285 these products with a dienophile through the Diels-Alder reaction confirmed the formation of vitamin

286 ycloadditions, as an alternative path to the Diels-Alder products, are highly disfavored.

287 patterns are challenging to access using the Diels-Alder reaction (the ortho-para rule).

288 acenes are attached to this module using the Diels-Alder reaction, which also forms one of the acene

289 ins uncertain if any of them proceed via the Diels-Alder mechanism.

290 Thermal Diels-Alder reactions of alpha-amido acrylates with N-Cb

291 polymers undergo a Michael-type addition to Diels-Alder (DA) adducts of furylated drugs and acetylen

292 esis of spinosyn A, catalyzes a transannular Diels-Alder reaction.

293 equisite for a successful diene transmissive Diels-Alder (DTDA) reaction by employing two different d

294 the preparative value of diene-transmissive Diels-Alder sequences since they offer products of regio

295 SpnF enzyme, one of the most promising "true Diels-Alderase" candidates.

296 ntial pericyclic reactions occur, namely two Diels-Alder/retro-Diels-Alder sequences, which can be pe

297 report the temperature dependent NMR of two Diels-Alder adducts of furan: one formed with maleic anh

298 d kidamycinone were achieved by means of two Diels-Alder reactions.

299 accessible from benzocyclobutenol, undergoes Diels-Alder reaction with vinylphosphine oxides, yieldin

300 Aromatics are formed via Diels-Alder cycloaddition with ethylene, which is produc