ライフサイエンスコーパス: E2F transcription factor

1 hat p14(ARF) can control the activity of the E2F transcription factor.

2 or protein (Rb), which in turn regulates the E2F transcription factor.

3 hat can be bypassed by overexpression of the E2F transcription factor.

4 s transcriptional activation mediated by the E2F transcription factor.

5 he S phase by modulating the activity of the E2F transcription factor.

6 cell death, which is likely mediated by the E2F transcription factor.

7 sed genes that are likely coregulated by the E2F transcription factor.

8 dk inhibitors to Cdks, and downregulation of E2F transcription factor.

9 a tumor suppressor that binds and represses E2F transcription factors.

10 elial cells, that mouse DDB2 is regulated by E2F transcription factors.

11 sis through inhibitory interactions with the E2F transcription factors.

12 ar proliferation and apoptosis by regulating E2F transcription factors.

13 acterize the functional link between MIF and E2F transcription factors.

14 s its function through its interactions with E2F transcription factors.

15 lation of CCNE1 by miR-874 is independent of E2F transcription factors.

16 ediated by their ability to inhibit specific E2F transcription factors.

17 igenesis, in part, through interactions with E2F transcription factors.

18 nt fashion, likely through the pRB-dependent E2F transcription factors.

19 proliferation through the regulation of the E2F transcription factors.

20 (RB) regulates S-phase cell cycle entry via E2F transcription factors.

21 cell proliferation by binding and inhibiting E2F transcription factors.

22 of the cell cycle and which are regulated by E2F transcription factors.

23 inding to and regulating the activity of the E2F transcription factors.

24 ied as a downstream target gene of the c-myc/E2F transcription factors.

25 showed that MageB2 enhances the activity of E2F transcription factors.

26 ion, termed hypo-phosphorylation, to release E2F transcription factors.

27 ulated during cell cycle progression through E2F transcription factors.

28 a family members suggested the regulation of E2F transcription factors.

29 enic plants with altered levels of different E2F transcription factors.

30 ssion, principally through regulation of the E2f transcription factors.

31 sensitivity to apoptosis through binding to E2F transcription factors.

32 origenesis largely through regulation of the E2F transcription factors.

33 t in response to the activation of the other E2F transcription factors.

34 ed cell cycle progression, expression of the E2F transcription factor 1 (E2F1) and loss of retinoblas

35 E2F transcription factor 1 (E2F1) is an important regula

36 ls increased, whereas Bcl2, pRb protein, and E2F transcription factor 1 (E2F1) levels decreased.

37 ies utilizing MDM2 inhibitors, we noted that E2F transcription factor 1 (E2F1) was down regulated upo

38 iting cell cycle regulators Cyclin E (cycE), E2F transcription factor 1 (e2f1), and string (stg).

39 CDK6 and its downstream E2F Transcription Factor 1 (E2F1), bind to the LRPPRC pr

40 reased expression of key cell cycle inducers E2F transcription factor 1 and cyclin E1.

41 xpression, which inhibits Src, and increased E2F transcription factor 1 expression, which regulates b

42 This role for RB1 was linked to both E2F transcription factor 1-driven upregulation of the an

43 for tumor progression and that it did so via E2F transcription factor 1-mediated regulation of androg

44 e homolog) and E2F1, E2F2 and E2F3 (encoding E2F transcription factors 1, 2 and 3, respectively).

45 ified a novel functional interaction between E2f Transcription Factor 2 (E2f2) and Brain Expressed X-

46 We found evidence that E2F transcription factor 3 (E2F3) drives these changes i

47 olved, we found here that HIV-1 Tat inhibits E2F transcription factor 3 (E2F3), CAMP-responsive eleme

48 egulators cell division cycle 34 (Cdc34) and E2F transcription factor 5 (E2F5).

49 The E2F transcription factor, a heterodimer of E2F and DP su

50 Hyperphosphorylated RB releases E2F transcription factors, activating a transcriptional

51 oiesis highlights the nonredundant nature of E2f transcription factor activities in cell growth and d

52 kinase (CDK) in allowing the accumulation of E2F transcription factor activity and induction of the S

53 dy of evidence has shown that the control of E2F transcription factor activity is critical for determ

54 Deregulated E2F transcription factor activity occurs in the vast maj

55 mbers, p107 and p130, function by repressing E2F transcription factor activity to limit the expressio

56 creases intracellular cAMP levels and boosts E2F transcription factor activity to promote cell prolif

57 Given the role of RB in controlling E2F transcription factor activity, we investigated the r

58 Rb family of proteins, which in turn control E2F transcription factor activity.

59 ontaining a retinoblastoma family member, an E2F transcription factor and its dimerization partner, a

60 bladder cancer, including the activation of E2F transcription factor and subsequent Ezh2 expression

61 the early-expressed genes, we identified an E2F transcription factor and the RNA-binding protein Pum

62 ate specific activator and repressor MYB and E2F transcription factors and indicate the possibility o

63 t this site overlaps with a binding site for E2F transcription factors and is subtly distinct from a

64 tion through inhibition of Rb complexes with E2F transcription factors and other regulatory proteins.

65 It also coactivates certain non-E2F transcription factors and promotes differentiation.

66 We find that e1a displaces RBs from E2F transcription factors and promotes p300 acetylation

67 from G(1) to S phase is mainly controlled by E2F transcription factors and RB family proteins.

68 lastoma (Rb) family members interacting with E2F transcription factors and recruiting heterochromatin

69 cycle progression, in part, by sequestering E2F transcription factors and repressing E2F-responsive

70 (pRb) mediates cell cycle control by binding E2F transcription factors and repressing expression from

71 pRb) restrains cell proliferation by binding E2f transcription factors and repressing the expression

72 tein (pRb), which normally functions to bind E2F transcription factors and restrict expression of gen

73 that Dnmt1 is transcriptionally regulated by E2F transcription factors and that retinoblastoma protei

74 s, resulting in the dissociation of pRb from E2F transcription factors and the premature cell progres

75 in noncycling cells by complexes between the E2F transcription factors and the retinoblastoma (Rb) tu

76 Much circumstantial evidence implicates both E2F transcription factors and the retinoblastoma protein

77 ls exit the cell cycle through the action of E2F transcription factors and the retinoblastoma tumor s

78 The E2F transcription factors and the RETINOBLASTOMA-RELATED

79 te cell-cycle exit through inhibition of the E2F transcription factors and the transcriptional repres

80 luding those encoding the G1/S cyclin D3 and E2F transcription factors and their targets.

81 y dependent upon its capacity to inhibit the E2F transcription factors and thereby cell proliferation

82 ary for regulating binding interactions with E2F transcription factors and transcription repressors t

83 Rb and related proteins act as regulators of E2F transcription factors, and RbAp48 may act with such

84 The c-Myc and E2F transcription factors are among the most potent regu

85 E2F transcription factors are central regulators of cell

86 Mammalian E2F transcription factors are composed of E2F and DP sub

87 E2F transcription factors are critical regulators of cel

88 E2F transcription factors are critical, conserved regula

89 E2F transcription factors are generally believed to be p

90 E2F transcription factors are implicated in diverse cell

91 E2F transcription factors are important regulators of ce

92 E2F transcription factors are important regulators of th

93 en together, these data demonstrate that the E2F transcription factors are integral to HER2+ tumor de

94 The E2F transcription factors are key cell cycle regulators

95 The E2F transcription factors are key downstream targets of

96 The E2f transcription factors are key downstream targets of

97 E2F transcription factors are key participants in the re

98 E2F transcription factors are key players in the regulat

99 E2F transcription factors are key regulators of cell pro

100 E2F transcription factors are known regulators of the ce

101 E2F transcription factors are major regulators of cell p

102 E2F transcription factors are master regulators of the e

103 e consequences on downstream targets such as E2F transcription factors are not known.

104 The E2F transcription factors are thought to be key downstre

105 E2F transcription factors are thought to influence the G

106 A variety of studies implicate the E2F transcription factor as a critical regulator of the

107 Activation of E2F transcription factors at the G1-to-S phase boundary,

108 n activities are mediated by their different E2F transcription factor binding partners.

109 core promoter region contains two functional E2F transcription factor binding sites.

110 e M606 response, which contained overlapping E2F transcription factor binding sites.

111 line) raised cyclin D1 expression, increased E2F transcription factor binding to cyclin D1 promoter,

112 Rb negatively regulates multiple E2F transcription factors, but the role of the different

113 y abrogating the transcription repression of E2F transcription factors by the retinoblastoma suscepti

114 pic expression of Drosophila Cyclin E or the E2F transcription factor can drive quiescent endoreplica

115 E2F transcription factors can activate or actively repre

116 Current models posit that E2F transcription factors can be divided into members th

117 ferating EC, which display repression of the E2F transcription factor coincident with TNF-induced apo

118 ry pathways (the Rb-like protein RBF and the E2F transcription factor complex components dE2F and dDP

119 verexpression also alters the composition of E2F transcription factor complexes.

120 The E2F transcription factor couples the coordinate expressi

121 fects during the S and G2 phases and induces E2F transcription factor-dependent cell death.

122 t on Sp1 is specific, in that the Stat-3 and E2F transcription factors did not undergo degradation un

123 athway analyses predicted activation of E2F (E2F transcription factor), DNA damage response, TP53 (tu

124 RB family mutant TECs, increased activity of E2F transcription factors drives increased expression of

125 Thus we have uncovered new functions for E2F transcription factors during development, including

126 Pocket proteins regulate the activity of E2F transcription factors during G1-S transition.

127 The activating E2F transcription factors, E2F1-3, contribute to these e

128 Furthermore, we demonstrate that the E2F transcription factors E2F4 and E2F5 directly regulat

129 predicted miR-142 target genes, the atypical E2F transcription factors E2f7 and E2f8, were most highl

130 Atypical E2F transcription factors (E2F7 and E2F8) function as ke

131 While the E2F transcription factors (E2Fs) have a clearly defined

132 lock cell cycle progression by inhibition of E2F transcription factors, experiments were conducted to

133 Drosophila contains two members of the E2F transcription factor family (E2f and E2f2), which co

134 e functional interaction between pRB and the E2F transcription factor family appears to be critical.

135 eading to enhanced expression of a subset of E2F transcription factor family gene targets.

136 The E2F transcription factor family is known to play a key r

137 The E2F transcription factor family plays a crucial and well

138 pRB-independent, noncanonical member of the E2F transcription factor family that acts as a transcrip

139 tify E2F7 as a novel member of the mammalian E2F transcription factor family that has properties of a

140 E2Fs 1-4 are part of the E2F transcription factor family with varied roles in mam

141 s p105RB (retinoblastoma, acting through the E2F transcription factor family) and p53 regulate cell p

142 the RB1 gene product, pRB, is to repress the E2F transcription factor family, but pRB also functions

143 l as that of the DNA-bending capacity of the E2F transcription factor family, in the activation of tr

144 Here, we show that members of the E2F transcription factor family, known to play a key rol

145 The affected genes include the E2F transcription factor family.

146 ion by binding and inhibiting members of the E2F transcription factor family.

147 gene product (pRB), including members of the E2F transcription factor family.

148 direct binding, subsequently activating the E2F transcription factor family.

149 ylate the retinoblastoma protein and release E2F transcription factors for progression through cell c

150 een suggested that the subsequent release of E2F transcription factors from inhibitory complexes may

151 cell transformation, in part, by displacing E2F transcription factors from the retinoblastoma protei

152 myocytes and other cell types by displacing E2F transcription factors from tumor suppressor "pocket"

153 The E2F transcription factor has demonstrated a role in G0 e

154 The family of E2F transcription factors have an essential role in medi

155 Because interactions between p130 and E2F transcription factors have been proposed to play a r

156 ammals, a large number of proteins including E2F transcription factors have been shown to interact wi

157 E2f transcription factors have distinct roles in the con

158 The E2F transcription factors have emerged as critical apopt

159 the pRB family and its principal target, the E2F transcription factor, have focused on cells that hav

160 best-known target of RB protein (pRB) is the E2F transcription factor; however, many other chromatin-

161 horylation prevents its association with the E2F transcription factor; however, the molecular basis f

162 Our understanding of roles for the E2F transcription factor in regulating apoptosis has pro

163 stand whether Rb function can be mediated by E2F transcription factors in a BM-derived hematopoietic

164 le entry and quiescence are regulated by the E2F transcription factors in association with RETINOBLAS

165 , we found that lipid overload activates the E2F transcription factors in BECs, which drive cell cycl

166 ress this and to further analyze the role of E2F transcription factors in development we have phenoty

167 USP37 was induced by E2F transcription factors in G1, peaked at G1/S, and was

168 Given the importance of E2F transcription factors in mammalian cell cycle regula

169 ignatures to predict involvement of specific E2F transcription factors in Myc-induced tumors.

170 ignatures, we predicted a role for activator E2F transcription factors in Neu-induced tumors.

171 thods, we predicted a role for the activator E2F transcription factors in the mouse mammary tumor vir

172 hematopoietic-specific miR-142 and atypical E2F transcription factors in the regulation of mature T

173 E2F transcription factors, including E2F3, directly modu

174 The E2F transcription factors induce the expression of many

175 environment lead to an activation of Myc and E2F transcription factors, induce senescence, and suppre

176 otein's activities in growth suppression and E2F transcription factor inhibition.

177 dependent expression of an antagonist of the E2F transcription factor inhibits viral replication in n

178 In prior work we demonstrated that loss of E2F transcription factors inhibits metastasis.

179 The E2F transcription factor integrates cellular signals and

180 The E2F transcription factor is a key cell cycle regulator.

181 The activity of the E2F transcription factor is controlled by physical assoc

182 The activity of the E2F transcription factor is regulated in part by pRB, th

183 E2F transcription factor is subject to stringent regulat

184 The family of E2F transcription factors is the key downstream target o

185 E2F transcription factors may play a pivotal role in the

186 These results suggest that E2F transcription factors may play a role in promoting m

187 o-oncoprotein, is cell-cycle regulated by an E2F transcription factor-mediated repression mechanism o

188 E2F transcription factors play a critical role in cell c

189 The E2F transcription factors play a critical role in contro

190 The E2F transcription factors play a critical role in coordi

191 E2F transcription factors play a critical role in the co

192 The E2F transcription factors play a key role in the regulat

193 E2F transcription factors play a major role in controlli

194 The E2F transcription factors play an essential role in regu

195 E2F transcription factors play an important role in the

196 aken together, these results reveal that the E2F transcription factors play key roles in mediating tu

197 E2F transcription factors play pivotal roles in controll

198 The E2F transcription factor plays a major role in cell cycl

199 The E2F transcription factor plays a pivotal role in the tim

200 atypical E2F family member E2F7 as the only E2F transcription factor potently up-regulated during on

201 ons, in part, by binding to and inactivating E2F transcription factors, preventing expression of E2F-

202 Unphosphorylated Rb can associate with E2F transcription factors, preventing transcription of g

203 Phosphorylation of RB releases E2F transcription factor proteins that transactivate cel

204 Since the E2F transcription factors provide growth impetus for the

205 E2F transcription factors regulate a variety of cellular

206 E2F transcription factors regulate genes expressed at th

207 E2F transcription factors regulate genes involved in cel

208 E2F transcription factors regulate the progression of th

209 o the human pRb tumor suppressor protein and E2F transcription factors, resulting in the dissociation

210 th RB proteins displaces them from DNA-bound E2F transcription factors, reversing their repression of

211 ression, activation of the Notch pathway via E2F transcription factors serves as a negative feedback

212 Certain E2F transcription factor species play a pivotal role in

213 ith peak expression in G1/S, is activated by E2F transcription factors (TFs) and is required for DNA

214 ed the expression of genes including p53 and E2F transcription factors that regulate the cell cycle i

215 long been known to target regulation of the E2F transcription factors, the downstream target of the

216 oblastoma (pRB) family proteins regulate the E2F transcription factors; their complexes regulate crit

217 additional roles of this pathway, especially E2F transcription factors themselves, in tumor progressi

218 Activation of E2F transcription factors, through disruption of the ret

219 CR2 binds RB family members, de-repressing E2F transcription factors, thus activating genes require

220 e Yap1/Tead2 complex acts cooperatively with E2F transcription factors to activate a cell cycle and D

221 l its growth-inhibitory effects and enabling E2F transcription factors to activate genes required for

222 , p107, and p130 pocket proteins bind to the E2F transcription factors to control gene expression.

223 (Rb) through phosphorylation, which releases E2F transcription factors to drive cell-cycle progressio

224 These results provide a mechanism for E2F transcription factors to overcome pRb-mediated domin

225 a hypophosphorylated state, associates with E2F transcription factors to prevent the activation of g

226 ation by G1-CDK of Whi5/Rb inhibitors of SBF/E2F transcription factors triggers irreversible S-phase

227 ulates the G1-S transition by binding to the E2F transcription factors, until cyclin-dependent kinase

228 ists to support the tenet that activation of E2F transcription factors, via alterations in the p16-cy

229 N-MYC promoter in cycling cells required the E2F transcription factor, we show that E2F-1 and HBP1 re

230 specificity of function within the family of E2F transcription factors, we have identified proteins t

231 Cellular genes regulated by the E2F transcription factors were strongly activated by the

232 sphorylated pRb binds to and inactivates the E2F transcription factor, which controls the expression

233 In contrast to the E2F transcription factors, which bind the p107 C-termina

234 GF signaling regulated the expression of the E2F transcription factors, which directly bound to and a

235 n proliferating cells include members of the E2F transcription factors, which mediate the expression

236 ly proteins binds to distinct members of the E2F transcription factors, which regulate the expression

237 ssing adenovirus E2 promoter binding factor (E2F) transcription factors, which drive the expression o

238 wn that prohibitin represses the activity of E2F transcription factors while enhancing p53-mediated t