ライフサイエンスコーパス: E3 ligase

1 2, K225, and K257 residues independent of an E3 ligase.

2 d OTUD5 as a specific stabilizer of the UBR5 E3 ligase.

3 SlBBX20 is a substrate of the CUL4-DDB1-DET1 E3 ligase.

4 evelopment of covalent inhibitors for an RBR E3 ligase.

5 plant ERAD system contains a plant-specific E3 ligase.

6 tion in melanoma cells by the ITCH ubiquitin E3 ligase.

7 ase due to loss-of-function of the gigaxonin-E3 ligase.

8 ly phospho-inactivates Nedd4-2, an ubiquitin E3 ligase.

9 ication and validation of targets of the GID E3 ligase.

10 (iDAb) fused to the UBOX domain of the CHIP E3 ligase.

11 omain of LGR4 conferred interaction with the E3 ligases.

12 r family is mirrored in the partner RBR-type E3 ligases.

13 acromolecules (macrodrugs) fused to specific E3 ligases.

14 , which is a distinctive feature of RBR-type E3 ligases.

15 itin ligase (WWP2) are HECT family ubiquitin E3 ligases.

16 G finger domains may be a general feature of E3 ligases.

17 tified relative to the ~ 600 predicted human E3 ligases.

18 is known to be tightly controlled by several E3 ligases.

19 (binding positions, scaffold-class) and the E3 ligases.

20 modification with ubiquitin, including ~600 E3 ligases.

21 Apoptosis-resistant E3 ligase 1 (AREL1) belongs to "other" subfamily HECT th

22 ligase WWP1 (WW domain-containing ubiquitin E3 ligase 1) suppressed the dimerization, membrane recru

23 Ubiquitin E3 ligase 3A (UBE3A) encodes an E3 ubiquitin ligase whos

24 Vif folds when it binds Cullin-RING E3 ligase 5 and the transcription cofactor CBF-beta.

25 Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubi

26 s a RING domain and exhibits both GTPase and E3 ligase activities.

27 The PIR1.2 exhibited E3 ligase activity and determined PP2CA stability in the

28 C-terminal RING domain, responsible for the E3 ligase activity and homodimerization.

29 horylates UFL1 at serine 462, enhancing UFL1 E3 ligase activity and promoting ATM activation in a pos

30 taICP0 virus or mutants with deficiencies in E3 ligase activity cannot counteract beta interferon (IF

31 er hand, reciprocally inhibits the ubiquitin E3 ligase activity of APC(Cdh1) through direct phosphory

32 d linear ubiquitin), but the function of the E3 ligase activity of HOIL-1 is unknown.

33 nduced kinase 1 (PINK1) activity, and Parkin E3 ligase activity toward CDGSH iron sulfur domain 1 (CI

34 chimeric UHRF1 (finger swap) with diminished E3 ligase activity toward nucleosomal histones, despite

35 -mediated ER protein reflux does not require E3 ligase activity, and proceeds even more vigorously wh

36 emimethylated DNA binding functions, but not E3 ligase activity, maintain cancer-specific DNA methyla

37 ysis of MDM2, one of the targets of the RLIM E3 ligase activity, showed consistent downregulation in

38 insight into allosteric regulation of UHRF1 E3 ligase activity, suggesting that UHRF1's SRA finger l

39 A, uncouples DNA affinity from regulation of E3 ligase activity.

40 ich is required for its self-association and E3 ligase activity.

41 an ICP0-dependent manner by inhibiting ICP0 E3 ligase activity.

42 hibits DNA-dependent ATP hydrolysis and SUMO E3 ligase activity.

43 a characteristic trait of ESCs, by enhanced E3-ligase activity of RNF2.

44 2) and its principal negative regulator, the E3 ligase adaptor Kelch-like ECH-associated protein 1 (K

45 elch-like (BBK) family of predicted cullin-3 E3 ligase adaptors: A55, C2, and F3.

46 arbon source-dependent regulation of the GID E3 ligase, an important regulator of cellular metabolism

47 in a reciprocal circuit with the cell cycle E3 ligase anaphase-promoting complex/cyclosome (APC/C),

48 Here, studying the 1.2-MDa E3 ligase anaphase-promoting complex/cyclosome (APC/C),

49 MMS21 encodes a SUMO E3 ligase and an essential component of the Smc5/6 compl

50 nzyme E2 E1 (UBE2E1), TRIM21 acts both as an E3 ligase and as a substrate in autoubiquitination.

51 ed by ubiquitination and deubiquitination by E3 ligase and DUB machinery positioned at the gate.

52 clear E2 enzyme that interacts with the RFA4 E3 ligase and forms UBC26-RFA4-receptor complexes in nuc

53 ons as a substrate adaptor of cullin 3-based E3 ligase and has a crucial role in various cellular pro

54 th impaired binding to the von Hippel-Lindau E3 ligase and PRMT5, respectively.

55 Employing ligands for cereblon/cullin 4A E3 ligase and SI-109, we obtained a series of potent PRO

56 eversal pathway licensed by ZATTZNF451 SUMO2 E3 ligase and SUMOylation of TOP2.

57 ylation and phosphorylation of the viral cis-E3 ligase and transactivator protein IE2 work in tandem

58 olved in ubiquitination signaling, including E3 ligases and deubiquitinases.

59 screened an RNAi library targeting ubiquitin E3 ligases and observed that knockdown of the E3 ligase

60 s to redirect the ubiquitination activity of E3 ligases and potently degrade a target protein within

61 in USP4 and USP15 are known to interact with E3 ligases and substrate recruitment factors.

62 ate E2 variants, including more than a dozen E3 ligases and their putative targets.

63 ulator of proteostasis in many cells, having E3-ligase and chaperone functions and often directing da

64 beta alters the phosphorylation of TRIM2 (an E3 ligase) and optineurin (an autophagy receptor), which

65 ffinities towards the target protein and the E3 ligase, and optimizing the PROTAC linker.

66 transfer from the destruction complex to the E3 ligase, and test models suggesting Dishevelled and AP

67 of a ubiquitin to the chain is catalyzed by E3 ligases, and removal of ubiquitin is catalyzed by a D

68 of the relatively unexplored plant RBR-type E3 ligases, and through mutagenesis and biochemical assa

69 dicate that compound 15 degraded PRMT5 in an E3 ligase- and proteasome-dependent manner.

70 RING-finger E3 ligases are instrumental in the regulation of inflamm

71 observations show the unexpected role of an E3 ligase as a co-receptor that directly participates in

72 Here, we identify the Gigaxonin-E3 ligase as the first regulator of ATG16L1 turn-over an

73 brane protein, and MGRN1, a RING superfamily E3 ligase, assemble to form a receptor-like ubiquitin li

74 of proteins, we first sought to identify the E3 ligase associated with Tat degradation.

75 athogen Magnaporthe oryzae and the RING-type E3 ligase AVRPIZ-T INTERACTING PROTEIN 10 (APIP10) negat

76 In Arabidopsis thaliana, two E3 ligases, BIG BROTHER (BB) and DA2, activate the laten

77 ntrol the subcellular location of the H2Bub1 E3 ligase, Bre1.

78 er of phosphorylated URI is dependent on the E3 ligase BTS.

79 lve a putative sterol-sensing domain in this E3 ligase, but was abolished when either membrane extrac

80 ous ubiquitination by several F-box-specific E3 ligases, but its degradation is prevented in cancer c

81 specific recruitment of the Rnf40-containing E3 ligase by Egr2, the central transcriptional regulator

82 that E6AP/UBE3A is distinguished from other E3 ligases by having a 12 nM binding site at the proteas

83 egradation of HER2 by the proteasome via the E3 ligase c-CBL.

84 ggers ubiquitination by the Hsp70-associated E3 ligase c-terminus of Hsp70-interacting protein (CHIP)

85 We also found that proteins sharing an E3 ligase can have closely related changes in their expr

86 Thus, MARCH E3 ligases can act as cofactors for antitumor Abs that t

87 ential generality of the paradigm that MARCH E3 ligases can mediate the antiproliferative response to

88 lation is the ubiquitylation of JAM-C by the E3 ligase Casitas B-lineage lymphoma (CBL), which contro

89 RING-type E3 ligases catalyze both reactions in collaboration with

90 d 3.0 muM), respectively, by introducing the E3 ligase cereblon-binding ligand pomalidomide to Mcl-1/

91 der, MS39 (compound 6), and a first-in-class E3 ligase cereblon-recruiting EGFR degrader, MS154 (comp

92 f and deliver their protein substrate to the E3 ligase complex for ubiquitination and subsequent degr

93 The INM-localized Asi E3 ligase complex is sufficient and necessary for recogn

94 urthermore, CRY1 and CRY2 cooperate with the E3 ligase complex SKP-CULLIN-FBXL3 (SCF(FBXL3)) to reduc

95 exes serve as an example of a cognate kinase-E3 ligase complex that selectively triggers rapid phosph

96 that, in addition to directing the Cul3-RING E3 ligase complex to degrade cellular/viral target prote

97 required for formation of the NPR1-Cullin 3 E3 ligase complex to ubiquitinate SINC-localized substra

98 h encodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of as risk factors for AS

99 or cofactor binding and stabilization of the E3 ligase complex, such as the zinc-binding motif and N-

100 tion component of the SCF(FBW7) multiprotein E3 ligase complex, targets both WT and tumor-derived mut

101 iated interaction with a Slimb/beta-TrCP SCF E3 ligase complex.

102 he anaphase-promoting complex/cyclosome-CDH1 E3 ligase complex.

103 the Cullin3-SPOP (speckle-type POZ protein) E3 ligase complex.

104 that FBXL16 might not form a functional SCF-E3 ligase complex.

105 availability, due to its role as part of an E3-ligase complex which targets the hypoxia-inducible fa

106 es, we characterized two related Cullin-RING E3 ligase complexes, Cul2(ZYG11B) and Cul2(ZER1), that a

107 FBXL2 is an important ubiquitin E3 ligase component that modulates inflammatory signalin

108 small molecules and the expression levels of E3 ligase components across hundreds of human cancer cel

109 terest (POI) and another to an E3 ubiquitin (E3) ligase, connected via a linker.

110 These results reveal a new mechanism of E3 ligase control of mTORC1 activity through the RNF186-

111 ism of antiviral restriction in which a TRIM E3 ligase controls viral replication by regulating the s

112 her demonstrate that PIF5 interacts with the E3 ligase COP1, promoting PIF5 stabilisation in light-gr

113 st two-hybrid screen assay and identified an E3 ligase, COP9 INTERACTING F-BOX KELCH 1 (CFK1), as a n

114 The Cullin-RING E3 ligase (CRL) family is commonly hijacked by pathogens

115 karyotic cell biology depends on cullin-RING E3 ligase (CRL)-catalysed protein ubiquitylation(1), whi

116 Cullin-Ring E3 Ligases (CRLs) regulate a multitude of cellular pathw

117 ubiquitination by deneddylating Cullin-RING E3 ligases (CRLs).

118 ges in protein expression can be coupled via E3 ligase crosstalk.

119 sed myoblast differentiation to identify the E3 ligase CUL2(FEM1B) and its substrate FNIP1 as core co

120 We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon ubiquitination pathway, ma

121 ochrome c is targeted for degradation by the E3 ligase CUL9 in neurons.

122 interest in developing strategies to target E3 ligases, de-ubiquitinases, and/or ubiquitin receptors

123 mals, neddylation is promoted by the five co-E3 ligases, defective in cullin neddylation 1 domain-con

124 ation of mutant but not wild-type EGFR in an E3 ligase-dependent manner in cancer cell lines and effe

125 H19, associates with dystrophin and inhibits E3-ligase-dependent polyubiquitination at Lys 3584 (refe

126 Here, we show that the catalytic E3 ligase domain of SspH1 can be divided into two subdom

127 Rhes interacts with Nix via SUMO E3-ligase domain, and Nix depletion totally abrogates Rh

128 Using a RING E3-ligase domain, DZIP3 interacted and increased K63-lin

129 88 as physiological substrates of the HOIL-1 E3 ligase during Toll-like receptor signaling.

130 The HECT E3 ligase family comprises three subfamilies: NEDD4 E3 u

131 In this study, we assessed the role of the E3 ligase FBXW7 in mature B-cell neoplasms.

132 ing (stg), while genetically depleting APC/C E3 ligase fizzy-related (fzr).

133 Here, we report that FBXW2 is an E3 ligase for beta-catenin.

134 gets BCL-X(L) to the Von Hippel-Lindau (VHL) E3 ligase for degradation.

135 which targets Bcl-xl to the cereblon (CRBN) E3 ligase for degradation.

136 ield mostly focus on choosing an appropriate E3 ligase for the target protein, improving the binding

137 CDC20 (APC/C(CDC20)) form the main ubiquitin E3 ligase for these two proteins.

138 cribe the identification of SCF-Fbxl8 as the E3 ligase for Thr-283 phosphorylated cyclin D3.

139 Here, we found that MDM2 acts as an E3 ligase for WRN protein.

140 s employ protein ubiquitylation by ubiquitin E3 ligases for functional regulation or protein quality

141 Hippel-Lindau and cereblon ligands to hijack E3 ligases for PTK2 degradation.

142 establishment domains are defined, including E3 ligase function, but the maintenance domains are poor

143 re within a disordered region contributes to E3 ligase function.

144 The conventional view posits that E3 ligases function primarily through conjugating ubiqui

145 e a revised allosteric mechanism for how CUL-E3 ligases function.

146 Variation in the promoter region of the HECT E3 ligase gene BnaUPL3 C03 made a major contribution to

147 olerance and overexpression of the rice SUMO E3 ligase gene OsSIZ1 improves heat and water deficit st

148 ide evidence that mutations in the ubiquitin E3 ligase gene RNF170, which targets inositol 1,4,5-tris

149 -associated degradation pathway, such as the E3 ligases gp78 and HRD1, which cooperate to catalyze PI

150 demonstrates that KSHV infection induces the E3 ligase HACE1 protein to regulate KSHV-induced oxidati

151 is increasingly recognized but, while a few E3 ligases have been shown to regulate nuclear export, e

152 uired for resistance to tunicamycin, whereas E3 ligase Hel2-mediated ubiquitination of uS10 was not.

153 a host BTB-BACK domain-containing ubiquitin E3 ligase homologue, leading to its rapid turnover.

154 gradation as directed by the yeast ERAD RING E3 ligases, Hrd1 and Doa10.

155 Previous studies have shown a role for the E3 ligase HUWE1 in modulating c-MYC, an oncogene frequen

156 We report here that RIPLET, an essential E3 ligase in antiviral immunity, promotes the antiviral

157 eleting the Rnf40 subunit of the responsible E3 ligase in mice.

158 of SV proteostasis and that Parkin is a key E3 ligase in the autophagy-mediated clearance of SV prot

159 Among the several RING-domain E3 ligases in humans, many utilize two distinct E2s for

160 epletion of the N-end rule pathway ubiquitin E3 ligases in NatB mutants did not restore NAD(+) levels

161 on and degradation is regulated by different E3 ligases in thyroid normal and tumor cells.

162 und, full-length LGR5 interacting with these E3 ligases in whole cells has not been reported, and onl

163 acrophages from knock-in mice expressing the E3 ligase-inactive HOIL-1[C458S] mutant, we identify IRA

164 nsformation through targeting of promiscuous E3 ligases, including FBW7, a known MMP-9 and Snail regu

165 G protein signaling protein 2 (RGS2) by its E3 ligase, increasing the potential for rational design

166 The E3 ligase inhibitor RTA405 enhanced SMAD3-regulated gene

167 and could be used to develop optimized ICP0 E3 ligase inhibitors.IMPORTANCE Since acyclovir and its

168 acid receptors and adaptors of Cullin3-based E3 ligase, interact with and mediate the degradation of

169 We identified UBR4 and UBR5 as ubiquitin E3 ligases involved in HC ER-associated degradation.

170 A KRAS-specific DARPin fused to the VHL E3 ligase is compared to a pan-RAS intracellular single

171 UFM1 specific ligase 1 (UFL1), an ufmylation E3 ligase, is important for ATM activation.

172 this study, we found that deficiency of the E3 ligase Itch, which leads to spontaneous colitis and r

173 polarization of macrophages deficient in the E3 ligase ITCH.

174 3 ligases and observed that knockdown of the E3 ligase Kelch-like protein 42 (KLHL42) impairs TGF-bet

175 is the first report of a PROTAC in which the E3 ligase ligand and targeting warhead combine to exert

176 von Hippel-Lindau (VHL) and cereblon (CRBN) E3 ligase ligands and a variety of linkers, which result

177 on with HOIP, the catalytic component of the E3 ligase linear ubiquitin assembly complex (LUBAC).

178 The E3 ligase Listerin (LTN1/Ltn1) acts in a specialized pro

179 ontrol (RQC), Rqc2/NEMF closely supports the E3 ligase Ltn1/listerin in promoting ubiquitylation and

180 ago truncatula, VAPYRIN (VPY) and a putative E3 ligase LUMPY INFECTIONS (LIN) are required for infect

181 n genome contains an estimated 600 ubiquitin E3 ligases, many of which are single-subunit E3s (ssE3s)

182 Here, we report that the E3 ligase MARCH2 is a novel negative regulator of NEMO-m

183 Upstream of USP30, the E3 ligase March5 ubiquitinates mitochondrial proteins wh

184 rom clinical biopsy tissues, we identify the E3 ligase MDM2 as a key regulator of prostate CSC integr

185 n2 ubiquitination was likely mediated by the E3 ligase MDM2 homolog (MDM2), indicated by an increased

186 Although the E3 ligase MDM2 is bound by the nutlin class of small-mol

187 ligand classes exemplified by antibodies, an E3 ligase, MDM2 proto-oncogene (MDM2), and protease (Spl

188 The E3 ligase membrane-associated ring-CH-type finger 6 (MAR

189 Our results suggest that the plant-specific E3 ligase MfSTMIR participates in the ERAD pathway by in

190 we explored the potential of novel cereblon E3 ligase modulators (CELMoDs) for the treatment of pati

191 natively regulated versus well characterised E3 ligases, MuRF1/MAFbx, at the gene expression level du

192 sion profile for UBR5 vs. well characterized E3-ligases, MuRF1/MAFbx, where, after atrophy evoked by

193 Here, we show that the HECT-domain E3 ligases NEDD4 and NEDD4L are expressed in the crypt s

194 DMD, chaperoned by Cdc37/Hsp90, recruits the E3 ligase, NEDD4, to catalyze polyubiquitination of pro-

195 This data demonstrates c-Cbl as an E3 ligase of PD-1 and a regulator of tumor microenvironm

196 Our screen identifies UBR5, an E3 ligase of the HECT-type family, as a novel regulator

197 ethodologies that have been used to identify E3 ligases or DUBs to facilitate the search for yet-to-b

198 , we demonstrate that tumor-derived UBR5, an E3 ligase overexpressed in human OC associated with poor

199 The E3 ligase Parkin is required for increased autophagy in

200 In concert with these E3 ligases, PDIA3 was shown to cleave ubiquitinated HC m

201 , the Dsc complex, and a newly characterized E3 ligase, Pib1.

202 Here, we identified a RING domain ubiquitin E3 ligase, PIR1 (PP2CA interacting RING finger protein 1

203 diated degradation, which is mediated by the E3 ligase PJA1 and show that this occurs through binding

204 eptor function, tripartite motif 21 (TRIM21) E3 ligase plays an essential role in the p62-Keap1-Nrf2

205 vious studies have also shown that ubiquitin E3 ligases potently control TGF-beta signaling through t

206 tructural analysis it was proposed that RING E3 ligases prime the E2~ubiquitin conjugate (E2~Ub) for

207 Here, PJA1, an E3 ligase, promoted ubiquitination and degradation of ph

208 which initial modification by a Cullin-RING E3 ligase promotes its chromatin association and express

209 ents of the plant immune system, through the E3 ligase PROTEOLYSIS (PRT)6.

210 E3 ligases provide a novel point of intervention for the

211 lation, since the targeted knockdown of PCNA E3-ligase (RAD18) and a non-ubiquitylable (PCNA K164R) k

212 odegron for the SCF (Skp-Cul-Fbox) ubiquitin E3-ligase receptor protein Fbxw7alpha (F-box/WD40 7).

213 E3 ligase recruiters remain central to this process yet

214 mplex, composed of the PROTAC, the POIs, and E3-ligases related proteins (E3Ps).

215 Here, we identify the E3 ligase RFWD3 as an essential modulator of stalled for

216 quitin E3 ligases, we identified a RING-type E3 ligase, ring finger protein 186 (RNF186), that critic

217 romoting its K63-linked ubiquitination by an E3 ligase RNF146, which blocks LKB1/STRAD/MO25 complex f

218 This action appears to be mediated by the E3 ligase RNF183.

219 truct combining the RING domain of ubiquitin E3 ligase RNF4 with a protein-specific camelid nanobody

220 ism: forming RSPO-bridged complexes with the E3 ligases RNF43 and ZNRF3 to inhibit ubiquitylation of

221 its homologs Lgr4/6 and stem-cell-expressed E3 ligases Rnf43/Znrf3, is expressed in nodose-petrosal

222 eletion reverts the nuclear export defect of E3 ligase Rsp5 mutants.

223 The E3 ligase S-phase kinase-associated protein 2(Skp2) is o

224 y, a SUMO acceptor site in COP1 and the SUMO E3 ligase SAP and Miz 1 (SIZ1).

225 iption factor, beta-Catenin, and its cognate E3 ligase, SCF(beta-TrCP).

226 iation of the kinase module depends upon the E3 ligase, SCF(FBW7) In addition, genetically insulin-re

227 Two distinct E3 ligases, SCF(FBXL19) and HECW1, degrade thyroid trans

228 ion of DYRK2 protein by inhibiting ubiquitin E3 ligase SIAH2 with vitamin K3 promoted apoptosis and a

229 rformed a dual-luciferase-based, genome-wide E3 ligase siRNA library screen and identified ASB13 as a

230 -methylation mutants, we identified the SUMO E3 ligase SIZ1 as a critical regulator of active DNA dem

231 cific peptidase 7) opposes the activities of E3 ligases, stabilizes DNA-bound NF-kB, and thereby prom

232 all ubiquitin-like protein SUMO and the SUMO E3 ligase Su(var)2-10 are required for piRNA-guided depo

233 adly to characterize the degronomes of other E3 ligase substrate receptors, including those that adhe

234 Overexpression of ubiquitin E3 ligase subunit FBXL19 increased TTF1 ubiquitination a

235 We demonstrate that the ubiquitin E3 ligase subunit FBXL2 is essential for skeletal myogen

236 by PROTAC has grown steadily, the number of E3 ligases successfully exploited to accomplish this has

237 lates the levels of proteins targeted by SCF-E3 ligases, such as C-MYC, beta-catenin, and steroid rec

238 /tramtrack/bric-a-brac) subunit of ubiquitin E3 ligases, suggesting enhanced regulation of protein dy

239 the approach to rediscover substrates of the E3 ligase targeting drug lenalidomide and to identify pr

240 allosteric, reversible PTP inhibitor with an E3 ligase targeting ligand through a well-designed linke

241 with LT stabilization, decrease in the Skp2 E3 ligase targeting these LT proteins for degradation, a

242 ctivation is driven through the LSD, a known E3 ligase-targeting domain, in MCC.

243 teomic approach, we identified TRIM28 as the E3 ligase that catalyzes SUMO2-PCNA conjugation.

244 -phase kinase-associated protein 2 (SKP2) as E3 ligase that executes lysine-48-linked poly-ubiquitina

245 (PIAS) 1, a small ubiquitin-related modifier E3 ligase that facilitates C/EBPbeta degradation.

246 Here, we report that HOIL-1 is an atypical E3 ligase that forms oxyester bonds between the C termin

247 una is an evolutionarily conserved ubiquitin E3 ligase that has been identified as a crucial regulato

248 RNF43 is an E3 ligase that inhibits Wnt signaling by ubiquitinating

249 Here we identify COP1 as the ubiquitin E3 ligase that is essential for LT-induced c-Jun degrada

250 which encodes an ER-membrane-localized RING E3 ligase that is highly conserved in leguminous plants,

251 Our findings establish gigaxonin as a key E3 ligase that positively controls the initiation of Shh

252 To date, the SUMO E3 ligase that provides substrate specificity for SUMO2-

253 However, the E3 ligase that regulates phosphorylated cyclin D3 and wh

254 eriments, we establish Pib1 as the ubiquitin E3 ligase that regulates Rds2 ubiquitination and stabili

255 y SCF-FBXL17, a dimerization-quality-control E3 ligase that ubiquitylates and helps to degrade inacti

256 Therefore, identifying and recruiting the E3 ligases that are enriched in tumors with minimal expr

257 Here we identify 2 distinct ubiquitin E3 ligases that are responsible for TTF1 degradation in

258 s developed have utilized ligands to recruit E3 ligases that are ubiquitously expressed in both tumor

259 y be unlocked by expanding the repertoire of E3 ligases that can be recruited by PROTAC.

260 hitecture and chemical tractability of human E3 ligases that could expand the toolbox for PROTAC disc

261 en RNA helicases and tripartite motif (TRIM) E3 ligases that lead to their functional coordination in

262 interaction partners, including a number of E3 ligases that modulate DHCR14 levels.

263 n ligase PIRE (PBL13 interacting RING domain E3 ligase) that interacts with both PBL13 and RBOHD.

264 otein (FANCD2) by the multisubunit ubiquitin E3 ligase, the FA core complex, is an obligate step in a

265 reveal that a single substrate can engage an E3 ligase through multiple binding modes, affecting its

266 , interact with their cognate TRIM/TRIM-like E3 ligases through similar epitopes in the helicase doma

267 the PPP, by inhibiting the newly identified E3 ligase TIRM21 and promotes the PPP.

268 lysis targeting chimera (PROTAC) recruits an E3 ligase to a target protein to induce its ubiquitinati

269 at UBP12/UBP13 counteracts the effect of NLA E3 ligase to accelerate leaf senescence under nitrogen s

270 -related proteins using the same warhead and E3 ligase to heretofore underappreciated aspects of the

271 tion of NLA (nitrogen limitation adaptation) E3 ligase to maintain ORE1 homeostasis.

272 eratinocytes, we propose that E7 hijacks the E3 ligase to promote the viral replicative cycle.

273 PROTACs recruit the E3 ligase to the POI and cause proximity-induced ubiquit

274 ween membrane-embedded cytoplasmic ubiquitin E3 ligases to conjugate heterotypic branched or mixed ub

275 lls make use of hundreds of unique ubiquitin E3 ligases to ensure proteome fidelity and control cellu

276 Heterobifunctional molecules, which recruit E3 ligases to ubiquitinate a target protein of interest,

277 recognizing Akt K64 methylation and recruits E3 ligase TRAF6 and Skp2-SCF to the Akt complex, indepen

278 Here, we report that the E3 ligase TRAF6 binds to and mediates the K63-linked pol

279 ubiquitination at lysine 262 mediated by the E3 ligase TRAF6.

280 ependent ubiquitination by the action of the E3 ligases Ubr1 and San1, allowing detailed study of pro

281 lic response, which included upregulation of E3 ligases UBR2 and atrogin1/MAFbx, increased LC3-II, an

282 We show that the E3 ligase UBR5 interacts with components of the replicat

283 iquitination and degradation mediated by the E3 ligase UBR5.

284 atients including mutations in the ubiquitin E3 ligase UBR5.

285 in chains conjugating onto K89 of AGR2 by an E3 ligase UBR5.

286 The Cullin 5 (CUL5) Ring E3 ligase uses adaptors Elongins B and C (ELOB/C) to bin

287 We previously identified a novel cullin-RING E3 ligase utilizing F-box only protein 44 (FBXO44) as th

288 Here we show that the E3 ligase VHL interacts with Daam2 and their mutual anta

289 ally target BCR-ABL1 protein and recruit the E3 ligase Von Hippel-Lindau, resulting in ubiquitination

290 Here, we described the discovery of a novel E3 ligase von Hippel-Lindau-recruiting EGFR degrader, MS

291 g a single warhead (foretinib) and recruited E3 ligase (von Hippel-Lindau).

292 to uncovering extended specificities of UBR E3 ligases, we characterized two related Cullin-RING E3

293 oach of an siRNA library targeting ubiquitin E3 ligases, we identified a RING-type E3 ligase, ring fi

294 (SCF) complexes compose the largest group of E3 ligases whose specificity is determined by a diverse

295 Understanding crosstalk and competition for E3 ligases will be key in ultimately developing a global

296 O, whereas LGR5 did not interact with either E3 ligase with or without RSPO.

297 y domain of RNF168, E7 binds directly to the E3 ligase without affecting its enzymatic activity.

298 Polyubiquitination by the ubiquitin E3 ligase WWP1 (WW domain-containing ubiquitin E3 ligase

299 r copper level leads to the activation of an E3-ligase, XIAP, which potentiates IL-17-induced NFkappa

300 ulti-step molecular process initiated by the E3 ligase ZNF598 through sensing of ribosomes collided a