ライフサイエンスコーパス: E3 ubiquitin ligase

1 a target-binding domain directly fused to an E3 ubiquitin ligase.

2 ents facilitates ubiquitination by the SIAH1 E3 ubiquitin ligase.

3 ation (TDMD) required the ZSWIM8 Cullin-RING E3 ubiquitin ligase.

4 brings its target protein in contact with an E3 ubiquitin ligase.

5 the autoubiquitination and degradation of an E3 ubiquitin ligase.

6 y effects on ICP0 but not on Mdm2, a control E3 ubiquitin ligase.

7 maternal allele of UBE3A, a gene encoding an E3 ubiquitin ligase.

8 n Fbxo45, two components of an intracellular E3 ubiquitin ligase.

9 romoter with Parkin (PRKN), which encodes an E3 ubiquitin ligase.

10 N-45/Raf for degradation by the SEL-10/FBXW7 E3 ubiquitin ligase.

11 hich act as substrate adaptors of CUL3-based E3 ubiquitin ligases.

12 tors, transcriptional elongation factors and E3 ubiquitin ligases.

13 ll-permeable inhibitors of thioester-forming E3 ubiquitin ligases.

14 RING ligases (CRLs) form the major family of E3 ubiquitin ligases.

15 L-1 are both members of the RBR subfamily of E3 ubiquitin ligases.

16 cts as substrate-specific adaptors to Cullin E3 ubiquitin ligases.

17 single-protein and multicomponent RING-type E3 ubiquitin ligases.

18 tial components of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases.

19 duced expression of TRB3 and muscle-specific E3-ubiquitin ligases.

20 blast growth factor 2 (FGF2) and Ariadne RBR E3 ubiquitin ligase 2 (ARIH2).

21 he FA core complex-a megadalton multiprotein E3 ubiquitin ligase(6,7).

22 HECT domain of Nedd4L (Ca(V)-abetalator), an E3 ubiquitin ligase, ablated currents from diverse HVACC

23 for the Wwp2 protein, which is an HECT-type E3 ubiquitin ligases abundantly expressed in articular c

24 RLIM, also known as RNF12, is an X-linked E3 ubiquitin ligase acting as a negative regulator of LI

25 undation for a detailed understanding of its E3 ubiquitin ligase activity and DNA interstrand crossli

26 in vitro evidence that Arabidopsis LNPs have E3 ubiquitin ligase activity and that LNP1 can directly

27 effects of the SUMO-SIM interaction on ICP0 E3 ubiquitin ligase activity regarding PML II degradatio

28 hanism by which ICP0 functions is through an E3 ubiquitin ligase activity that induces the degradatio

29 e motility factor (AMF) receptor (AMFR) with E3 ubiquitin ligase activity that plays a significant ro

30 e with PHD and RING finger domains 1 (UHRF1) E3 ubiquitin ligase activity toward histone H3, a mechan

31 gase E3 Component N-Recognin7 (UBR7) harbors E3 ubiquitin ligase activity toward monoubiquitination o

32 TRAF6 E3 ubiquitin ligase activity was required for the former

33 ZEITLUPE (ZTL), a photoreceptor with E3 ubiquitin ligase activity, communicates end-of-day li

34 y adaptors in a mechanism independent of its E3 ubiquitin ligase activity.

35 o identify small-molecule inhibitors of ICP0 E3 ubiquitin ligase activity.

36 d by p53 protein degradation mediated by the E3-ubiquitin ligase activity of MDM2.

37 ngs highlight the critical importance of the E3 ubiquitin ligase adaptor KLHL15 in proteostasis of ne

38 The E3 ubiquitin ligase adaptor speckle-type POZ protein (SP

39 quired for binding and ubiquitination by the E3 ubiquitin ligase AIP4 (atrophin-interacting protein 4

40 or of the anaphase promoting complex (APC/C) E3 ubiquitin ligase, Ama1.

41 due to a balance between the actions of the E3 ubiquitin ligase anaphase-promoting complex or cyclos

42 MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial

43 Casitas B lymphoma (c-Cbl) is an E3 ubiquitin ligase and a negative regulator of colorect

44 se-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle

45 Skp2 is a crucial component of SCF(Skp2) E3 ubiquitin ligase and is often overexpressed in variou

46 rved Pseudomonas effector AvrPtoB acts as an E3 ubiquitin ligase and promotes bacterial virulence.

47 Through the cooperative actions of E3 ubiquitin ligases and deubiquitinases, ubiquitin modi

48 s system is the physical interaction between E3 ubiquitin ligases and deubiquitylases (DUBs).

49 Here, we screened more than 280 E3 ubiquitin ligases and discovered that the endoplasmic

50 MAGEs assemble with E3 ubiquitin ligases and function as substrate adaptors

51 s a substrate adaptor for cullin3-containing E3 ubiquitin ligases, and KLHL15 gene mutations were rec

52 Finally, the Siah2 E3 ubiquitin ligase antagonizes drebrin function, sugges

53 and interaction with cullin 4A-DBB1 (DCAF1) E3 ubiquitin ligase are required for REAF degradation by

54 ) governing the recognition of substrates by E3 ubiquitin ligases are critical to cellular function.

55 ng antagonistic roles of two closely related E3 ubiquitin ligases are required for netrin-1-dependent

56 Because E3 ubiquitin ligases are the primary determinants of sub

57 ations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal reces

58 CTD5) protein, a putative adaptor of cullin3 E3 ubiquitin ligase, as a novel TRPM4-interacting protei

59 substrate recruiting subunit of the SCF-Skp2 E3 ubiquitin ligase, as an early repression target of pR

60 We identify SIAH2, a RING finger E3 ubiquitin ligase associated with the cellular hypoxic

61 In this study, we report that TRIM58, a RING E3-ubiquitin ligase, associates with TLR2.

62 alized hFAST binds to the WD40 domain of the E3 ubiquitin ligase beta-TrCP and blocks its interaction

63 of these serines enables recognition by the E3 ubiquitin ligase beta-TrCP.

64 n and proximal to a previously characterized E3 ubiquitin ligase-binding site.

65 Although the E3 ubiquitin ligase BRCA1 is a key player in maintenance

66 The conserved yeast E3 ubiquitin ligase Bre1 and its partner, the E2 ubiquit

67 e phosphopeptide analyses, we found that the E3 ubiquitin ligase c-Cbl preferentially targets LynA vi

68 t, to proteasomal degradation of mTOR by the E3 ubiquitin ligase c-Cbl.

69 whereas the screen suggested that Rnf20, an E3 ubiquitin ligase, can serve as a negative regulator o

70 which targeting BRD4 for degradation via the E3 ubiquitin ligase cereblon (CRBN) pathway leads to sus

71 otein, we focused our attention on host cell E3 ubiquitin ligase CHIP (C terminus of HSP70-binding pr

72 ation of MAST1 at lysines 317 and 545 by the E3 ubiquitin ligase CHIP and prevented proteasomal degra

73 ed by proteasome through the activity of the E3 ubiquitin ligase CHIP.

74 ruling out competitive binding to A3G or the E3 ubiquitin ligase complex as the sole mechanism.

75 The cereblon E3 ubiquitin ligase complex can recruit endothelial cell

76 An E3 ubiquitin ligase complex CONSTITUTIVELY PHOTOMORPHOGE

77 We found that a modular E3 ubiquitin ligase complex CRL4(DCAF12) binds and targe

78 ns in the Kelch-like 3-Cullin 3 (KLHL3-CUL3) E3 ubiquitin ligase complex have shed light on the impor

79 (KAI2), triggering its association with the E3 ubiquitin ligase complex SCF(MAX2) and downstream tar

80 gene, which encodes a core component of the E3 ubiquitin ligase complex that mediates proteasomal de

81 s the substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradati

82 d CUL4, components of a putative green algal E3 ubiquitin ligase complex, as critical factors in a si

83 cereblon (CRBN), a substrate receptor of an E3 ubiquitin ligase complex, is an increasingly importan

84 s a molecular feedback loop via the COP1/SPA E3 ubiquitin ligase complex, suggesting a mechanism that

85 P, the substrate recognition component of an E3 ubiquitin ligase complex, targets DMRT1 for degradati

86 AP), that forms part of an SKP1/Cullin/F-box E3 ubiquitin ligase complex.

87 bstrate receptor of the Cul4A-DDB1-CRBN-RBX1 E3 ubiquitin ligase complex.

88 leading to the membrane assembly of the 3-M E3 ubiquitin ligase complex.

89 s substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex.

90 yclosome (APC/C), which is the largest known E3 ubiquitin-ligase complex and has been implicated in r

91 BPM proteins are part of the Cullin E3 ubiquitin ligase complexes and are known to bind at l

92 E3 ubiquitin ligase complexes facilitate the post-transl

93 associated protein 2 (SKP2) as components of E3 ubiquitin ligase complexes that mediate YTHDF2 proteo

94 at propeller (KREP) domains usually found in E3 ubiquitin ligase complexes that target substrate prot

95 biology that encodes a component of SCF-type E3 ubiquitin ligase complexes.

96 roline hydroxylase (PHD, alias EGLN), and an E3 ubiquitin ligase component for HIF destruction called

97 Here, we find that loss of Fbxw7, an E3 ubiquitin ligase component, enhances the myelinating

98 ng complex, or cyclosome (APC/C), is a large E3 ubiquitin ligase composed of 14 subunits.

99 for their subsequent colocalization with the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP

100 ded changes in GA levels and depended on the E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC1 (CO

101 The Arabidopsis thaliana E3 ubiquitin ligase COP1 functions in ABA-mediated stoma

102 ereblon (CRBN), a substrate-receptor for the E3-ubiquitin ligase CRL4(CRBN), to trigger tau ubiquitin

103 Cullin-RING E3 ubiquitin ligases (CRLs) are large and diverse multis

104 itin-like protein that activates cullin-RING E3 ubiquitin ligases (CRLs).

105 nstrate that COP1, the substrate receptor of E3 ubiquitin ligase CUL4(COP) (1-) (SPA) (s) , interacts

106 Moreover, we observed that the E3 ubiquitin ligase cullin 2 (CUL2) critically regulates

107 ne new identified interaction partner is the E3 ubiquitin ligase cullin 3, which was revealed to regu

108 Here, we report that the E3 ubiquitin ligase Cullin 5/RBX2 (CRL5) controls the st

109 ore, we identified a P3-inducible U-box type E3 ubiquitin ligase, designated as P3-inducible protein

110 r mTOR signaling components, their modifying E3 ubiquitin ligases, deubiquitinases and corresponding

111 ow that the ER-associated degradation (ERAD) E3 ubiquitin ligase Doa10 controls cytoplasmic level of

112 At the end of a three-enzyme cascade, E3 ubiquitin ligases (E3s) recruit substrates and promot

113 f benign tumors, interacts with the cellular E3 ubiquitin ligase E6-associated protein (E6AP).

114 TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate morphogen

115 and ubiquitination assays, we show that the E3 ubiquitin ligase F-box and WD repeat domain-containin

116 E3-ubiquitin ligase F-box and WD40 repeat domain contain

117 ggers ERG recognition and degradation by the E3 ubiquitin ligase FBW7 in a manner independent of a ca

118 In this study, we show that the E3 ubiquitin ligase Fbw7 is required for the maintenance

119 ure 2018;564:130-135) has now identified the E3 ubiquitin ligase FBXO38 as a crucial regulator of PD-

120 In our study, we examined how the E3 ubiquitin ligase FBXO7-SCF (SKP1, Cul1, F-box protein

121 the result of its reduced degradation by the E3 ubiquitin ligase FBXW7.

122 ubiquitin protein ligase 1 (MIB1) as a novel E3 ubiquitin ligase for WRN protein.

123 es beta-cat and transfers it to the SCF-TrCP E3-ubiquitin ligase for ubiquitination and destruction.

124 OTOMORPHOGENIC1 (COP1) is a highly conserved E3 ubiquitin ligase from plants to animals and acts as a

125 Parkin is an E3 ubiquitin ligase, functioning in mitophagy.

126 We determine that the Siah2 E3 ubiquitin ligase functions in a coincidence detection

127 olving ubiquitination and three antagonistic E3 ubiquitin ligases: Grr1 and Ptr1 maintained basal Sir

128 ortantly, fewer than 10 of the more than 600 E3 ubiquitin ligases have so far been exploited for targ

129 HeLa cell extracts and identify this as the E3 ubiquitin ligase, HECTD1.

130 Here we show that the E3 ubiquitin ligase Hectd3 is necessary for pathogenic T

131 expression and upregulation of MYC-regulated E3 ubiquitin ligases HECTD4 and MYCBP2, which promote AR

132 ion of the 40S ribosomal protein uS10 by the E3 ubiquitin ligase Hel2 (or RQT1) is required for RQC.

133 Neuroprotective disruptions of the E3 ubiquitin ligase highwire and c-Jun N-terminal kinase

134 Here we show that during homeostasis, the E3 ubiquitin ligase Highwire and the ubiquitin-proteasom

135 omplex (LUBAC), which is composed of the two E3 ubiquitin ligases HOIP and HOIL-1L and the adaptor pr

136 of OST1 (SnRK2.6) protein stability via the E3-ubiquitin ligase HOS15.

137 f Lin-12-like) controls the stability of the E3 ubiquitin ligase Hrd1 (hydroxymethylglutaryl reductas

138 oteomic analysis reveals the upregulation of E3 Ubiquitin ligase HUWE1 and DUBs like USP9X and UBP7 i

139 uclear bodies recruit both HIF-1alpha and an E3 ubiquitin ligase HUWE1, which promotes the ubiquitina

140 nctional mRNA encoding a fusion of the viral E3 ubiquitin ligase ICP0 and viral membrane glycoprotein

141 Previously, we identified E3 ubiquitin ligase IDOL as a negative regulator of brai

142 e find that Parkin (also known as PARK2), an E3 ubiquitin ligase implicated in Parkinson's disease an

143 y, targeted knockdown of Parkin, a canonical E3 ubiquitin ligase important for mitophagy, mirrored th

144 orchestration of FASN, depalmitoylases, and E3 ubiquitin ligase in response to cell contact.

145 d to investigate a novel and uncharacterized E3 ubiquitin ligase in skeletal muscle atrophy, recovery

146 Our work reveals how redox-responsive E3 ubiquitin ligases in M. oryzae mediate Sir2 accumulat

147 accomplished by the coordination of multiple E3 ubiquitin ligases, including Rsp5, the Dsc complex, a

148 The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL

149 ciated ring-CH type finger 6 (MARCH6), a key E3 ubiquitin ligase involved in ER-associated degradatio

150 This work identified Mindbomb 1 (MIB1), an E3 ubiquitin ligase involved in neurodevelopment, as cri

151 sp5, the Nedd4 family member in yeast, is an E3 ubiquitin ligase involved in numerous cellular proces

152 Parkin, an E3 ubiquitin ligase involved in Parkinson's disease, is

153 tocrine motility factor (AMF), as well as an E3 ubiquitin-ligase involved in the ER-associated degrad

154 transcription factor SALL4 by the CRL4(CRBN) E3 ubiquitin ligase is a plausible major driver of thali

155 The RNF168 E3 ubiquitin ligase is activated in response to double s

156 w that CRL4Mahj, an evolutionarily conserved E3 ubiquitin ligase, is essential for NSC reactivation (

157 The E3 ubiquitin ligase Itch regulates antibody levels and p

158 ge polarization, which is regulated by itchy E3 ubiquitin ligase (ITCH), a negative regulator of infl

159 nstrate a mechanism through which a distinct E3 ubiquitin ligase, ITCH, modulates DDR machinery in tr

160 The E3 ubiquitin ligase, ITCH, negatively regulates the tumo

161 The MCC binds and inhibits the mitotic E3 ubiquitin ligase, known as Cdc20-anaphase promoting c

162 ding to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degrada

163 psychiatric risk gene Cul3, which encodes an E3 ubiquitin ligase, leads to an upregulation of Cap-dep

164 cific inactivation of Mdm2, which encodes an E3 ubiquitin ligase, led to lethality at birth with a st

165 ng a pan-HDAC inhibitor with cereblon (CRBN) E3 ubiquitin ligase ligand.

166 udied for its role in activating cullin-RING E3 ubiquitin ligases, little is known about other substr

167 RQC) pathway targets for degradation via the E3 ubiquitin ligase Ltn1.

168 ctive anti-cSCC activity of knockdown of the E3 ubiquitin ligase MARCH4, the ATPase p97/VCP, the deub

169 modulate cellular gene expression.IMPORTANCE E3 ubiquitin ligases mark their substrates for degradati

170 report a novel regulatory mechanism: another E3 ubiquitin ligase Mdm2 directly binds parkin and enhan

171 Its levels are tightly regulated by the E3 ubiquitin ligase MDM2.

172 RNA helicases and E3 ubiquitin ligases mediate many critical functions in

173 -induced membrane-associated ring CH (MARCH) E3 ubiquitin ligase-mediated ubiquitination and downregu

174 adaptors for cullin-3 (Cul3) RING-box-based E3 ubiquitin ligases, mediating protein ubiquitylation f

175 na) RING Finger ABA-Related1 (RFA1) and RFA4 E3 ubiquitin ligases, members of the RING between RING f

176 Avadomide, a CRL4CRBN E3 ubiquitin ligase modulator, demonstrated clinical act

177 s F-box domain an SCF (Skp1-Cul1-F-box)-type E3 ubiquitin ligase module.

178 The E3 ubiquitin ligase MuRF1 plays an integral role in degr

179 arcomere associated with upregulation of the E3 ubiquitin ligases, MuRF1 and Atrogin-1.

180 have recently identified that a HECT domain E3 ubiquitin ligase, named UBR5, is altered epigenetical

181 at miR-1 directly regulates the 3'UTR of the E3 ubiquitin ligase Nedd4 Analysis of embryonic and adul

182 mouse models, we further discovered that the E3 ubiquitin ligase Nedd4 is required for developmental

183 has been reported in the gene locus for the E3 ubiquitin ligase NEDD4.

184 xylation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-expr

185 USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which mediates the degradati

186 RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling

187 down-regulation of the Crumbs complex by the E3 ubiquitin ligase Neuralized.

188 Infected cell protein 0 (ICP0), an E3 ubiquitin ligase of herpes simplex virus 1 (HSV-1), c

189 tion of WRN have been reported, however, the E3 ubiquitin ligase of WRN is little known.

190 d the functionally overlapping UBR1 and UBR2 E3 ubiquitin ligases of the Arg/N-degron pathway.

191 ES 1 (HOS1), which is known to either act as E3 ubiquitin ligase or affect chromatin organization, in

192 transcriptional activity and suggest that an E3 ubiquitin ligase other than FBXO25 regulates ELK-1 ub

193 Von Hippel-Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-trigger

194 Here, we identify E3 ubiquitin ligase PARK2 as a direct target of ELK1, a

195 m to clear damaged mitochondria involves the E3 ubiquitin ligase Parkin and PTEN-induced kinase 1 (PI

196 Mutations in the E3 ubiquitin ligase parkin are the most common known cau

197 Loss-of-function mutations in the E3 ubiquitin ligase parkin have been implicated in the d

198 The E3 ubiquitin ligase parkin is a critical regulator of mi

199 The E3 ubiquitin ligase Parkin promotes the degradation of d

200 tion with the Parkinson's disease-associated E3 ubiquitin ligase Parkin.

201 ding to the oxidation and degradation of the E3 ubiquitin ligase parkin.

202 Here, we identified the E3 ubiquitin ligase Peli1 as an important regulator of T

203 ers GR protein turnover by up-regulating the E3 ubiquitin ligase Pellino-1, which catalyzes GR ubiqui

204 counteracting the action of the peroxisomal E3 ubiquitin ligase PEX2.

205 idate, we identify here a novel role for the E3 ubiquitin ligase Pib1 in regulating the stability and

206 g protein array technology, we identified an E3 ubiquitin ligase PIRE (PBL13 interacting RING domain

207 nistically with the F-box protein FBXO25, an E3 ubiquitin ligase previously shown to promote ELK-1 ub

208 se results suggest a novel role of host cell E3 ubiquitin ligase protein CHIP in regulating HIV-1 rep

209 lack of change in phosphorylated Nedd4-2, an E3 ubiquitin ligase protein which regulates the number o

210 Here, we report that two U-box type E3 ubiquitin ligases, PUB25 and PUB26, positively regula

211 UBR1-7, which are members of hundreds of E3 ubiquitin ligases, recognize and regulate the half-li

212 ers of the tripartite motif (TRIM) family of E3 ubiquitin ligases regulate immune pathways, including

213 ted RING-CH (MARCH) family of membrane-bound E3 ubiquitin ligases regulates the levels of cell-surfac

214 hase-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase, regulates the degradation of Mps3,

215 ARIH2 encodes TRIAD1, an E3 ubiquitin ligase required for termination of emergenc

216 membrane-associated RING-CH 8 (MARCH8), the E3 ubiquitin ligase responsible for MHC II ubiquitinatio

217 Key players in the UPS are E3 ubiquitin ligases, responsible for conjugation of ubi

218 at TRIM14, a noncanonical TRIM that lacks an E3 ubiquitin ligase RING domain, is a critical negative

219 Our analysis identified the E3 ubiquitin ligases ring finger protein 20 (RNF20) and

220 The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3

221 We found that eas-1 inhibits a conserved E3 ubiquitin ligase rnf-145/RNF145, which, in turn, prom

222 Here, we describe a mouse strain lacking the E3 ubiquitin ligase RNF146 that shows phenotypic similar

223 bosylation that is targeted by a PAR-binding E3 ubiquitin ligase, RNF146, leading to 53BP1 polyubiqui

224 Here we show that the E3 ubiquitin ligase RNF168, in addition to its canonical

225 Here, we investigate the role of the E3 ubiquitin ligase RNF20 and histone H2B monoubiquityla

226 The E3 ubiquitin ligase RNF4 contains multiple SIMs and conn

227 e, we show that this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-med

228 effect response to IgG 95 and uncovered the E3 ubiquitin ligase RNF41 as a driver of IgG 95 anti-pro

229 The E3 ubiquitin ligase RNF8 (RING finger protein 8) is a pi

230 n RNA interference screen, we found that the E3 ubiquitin ligase RNF8 suppresses a deletion rearrange

231 haromyces cerevisiae is mediated by the HECT E3 ubiquitin ligase Rsp5 and arrestin--related trafficki

232 d requires the E2 ubiquitin ligase Ubc4, the E3 ubiquitin ligase Rsp5, and K63-linked ubiquitin chain

233 d by a proteolytic cascade consisting of the E3 ubiquitin ligases SCF(Mdm30) and Rsp5, and the Cdc48

234 stability through polyubiquitylation by the E3 ubiquitin ligase Siah1.

235 We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppre

236 Here we reveal that the E3 ubiquitin ligase Speckle-type BTB-POZ protein (SPOP)

237 ar expression of monobodies fused to VHL, an E3 ubiquitin ligase substrate receptor, results in degra

238 that the von Hippel-Lindau (VHL) protein, an E3 ubiquitin ligase subunit, directly bound to G6PD and

239 ), which recruits A3 proteins to cullin-RING E3 ubiquitin ligases such as cullin-5 (Cul5) for ubiquit

240 quires a dynamic network of redox-responsive E3 ubiquitin ligases targeting fungal sirtuin 2 (Sir2),

241 g adaptor for RIG-I and MDA5, and Riplet, an E3 ubiquitin ligase that activates RIG-I.

242 SPA1 and CUL4 are components of a conserved E3 ubiquitin ligase that acts upstream of CrCO, whose re

243 HOIL-1 is a monoubiquitylating E3 ubiquitin ligase that initiates the de novo synthesis

244 ncer cells express high levels of RNF168, an E3 ubiquitin ligase that is critical for proper DNA repa

245 we suggest that: (i) UBR5 comprises a novel E3 ubiquitin ligase that is inversely regulated to MuRF1

246 rg motifs in RNF12/RLIM, a key developmental E3 ubiquitin ligase that is mutated in an intellectual d

247 derstanding of TRAIP, a replisome-associated E3 ubiquitin ligase that is mutated in microcephalic pri

248 Parkin is an E3 ubiquitin ligase that is regulated by ubiquitination

249 RLIM is an E3 ubiquitin ligase that leads to the ubiquitination and

250 phosphorylation (inhibition) of Nedd4-2, an E3 ubiquitin ligase that mediates hERG degradation.

251 of UBASH3A mediates its binding to CBL-B, an E3 ubiquitin ligase that negatively regulates CD28-media

252 PML stabilizes p53 by sequestering MDM2, an E3 ubiquitin ligase that targets p53 for degradation, to

253 RNF128 is an E3 ubiquitin ligase that targets p53 for degradation.

254 UBE3A is an E3 ubiquitin ligase that targets proteins for degradatio

255 Von Hippel-Lindau (VHL) is an E3 ubiquitin ligase that targets proteins, including HIF

256 NA library screen and identified ASB13 as an E3 ubiquitin ligase that targets SNAI2 for ubiquitinatio

257 e-promoting complex/cyclosome (APC/C) is the E3 ubiquitin ligase that, together with its co-activator

258 Of this latter set, we identified the E3 ubiquitin ligase TNF receptor-associated factor 6 (TR

259 etero-bifunctional molecules that recruit an E3 ubiquitin ligase to a given substrate protein resulti

260 hosphorylation can disrupt the binding of an E3 ubiquitin ligase to an E2-conjugating enzyme, leading

261 the host DNA damage-binding protein 1 (DDB1) E3 ubiquitin ligase to target Smc5/6 for degradation.

262 A damage-binding protein 1 (DDB1)-containing E3 ubiquitin ligase to target Smc5/6 for degradation.

263 en made in understanding the contribution of E3 ubiquitin ligases to health and disease, including th

264 Here we show that the E3 ubiquitin ligase TRAIP is required for both pathways.

265 lation on its MCM7 subunit, dependent on the E3 ubiquitin ligase TRAIP.

266 The E3 ubiquitin ligase TRIM21 plays a crucial role as a neg

267 is mediated by the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21.

268 In this study, we demonstrated that the E3 ubiquitin ligase TRIM29 is a crucial regulator of NK

269 Here, we report that the host E3-ubiquitin ligase TRIM6 promotes VP35 ubiquitination a

270 tein (E) of ZIKV is polyubiquitinated by the E3 ubiquitin ligase TRIM7 through Lys63 (K63)-linked pol

271 ein kinase A-mediated phosphorylation of the E3 ubiquitin ligase TRIM71.

272 ess fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing p

273 receptor-associated kinase-1 (IRAK1) by the E3 ubiquitin ligase tumor necrosis factor receptor-assoc

274 -amidase, arginyltransferase, and the double-E3 ubiquitin ligase UBR1-RAD6/UFD4-UBC4/5 are shown to f

275 part, through promoting the activity of the E3 ubiquitin ligase UBR2 towards L1-ORF1p.

276 rough the activity of the E7-associated host E3 ubiquitin ligase UBR4.

277 y investigate this novel and uncharacterised E3 ubiquitin ligase (UBR5) in skeletal muscle atrophy, r

278 Interestingly, a putative E3 ubiquitin ligase, UBR7, directly interacts with the T

279 Parkin is an E3 ubiquitin ligase well-known for facilitating clearanc

280 argets are the cullins, scaffold subunits of E3 ubiquitin ligases, where neddylation as well as dened

281 upregulates TRAIP, a RING domain-containing E3 ubiquitin ligase which dephosphorylates IkB and imped

282 ndosomes, RAB7 directly interacts with TRAF6 E3 ubiquitin ligase, which catalyzes K63 polyubiquitinat

283 ed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and p

284 lucose induces ubiquitination of G6PD by VHL E3 ubiquitin ligase, which leads to ROS accumulation and

285 Our study also identified an E3 ubiquitin ligase, which targets the RdDM compotent NR

286 Ubiquitin E3 ligase 3A (UBE3A) encodes an E3 ubiquitin ligase whose loss from the maternal allele

287 In particular, BRCA1, an E3 ubiquitin ligase with a key role in several DNA repai

288 MuRF1 (TRIM63) is a RING-type E3 ubiquitin ligase with a predicted tripartite TRIM fol

289 own to induce tripartite motif (TRIM) 21, an E3 ubiquitin ligase with critical functions in autoimmun

290 HACE1 is an E3 ubiquitin ligase with important roles in tumor biolog

291 TRIM32 is an E3 ubiquitin ligase with innate antiviral activity.

292 The UBE3A gene encodes an E3 ubiquitin ligase with three known protein isoforms in

293 the Skp1-Cul1-F-box-protein (SCF) family of E3 ubiquitin ligases with the F-box protein Cyclin F at

294 8 is a poorly characterized RNA-binding RING E3-ubiquitin ligase with functions in embryonic developm

295 ng cells, we show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppressing transme

296 d show that this network is regulated by the E3 ubiquitin ligase WWP2, specifically by the WWP2-N ter

297 in ligase (NEDD4-1) and WW domain-containing E3 ubiquitin ligase (WWP2) are HECT family ubiquitin E3

298 The E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIA

299 e show that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt s

300 The transmembrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and