ライフサイエンスコーパス: EC50

1 EC50s for the metabolite mixtures formed by ELW1 were lo

2 The screening hit (1, EC50 = 120 nM) was optimized to lead molecules with low

3 lations between functional output, such as 1/EC50, and effective kinetic constants for a range of dif

4 alizing antibody response above 3.02 log(10) EC50 was determined as a correlate of protection in maca

5 ara-methoxyphenyl at C-8 led to compound 12 (EC50 = 0.022 muM), twice as potent as its para-bromo ana

6 luoro-1H-indole-3-yl)methane (38, PSB-15160, EC50 80.0 nM) and di(5,7-difluoro-1H-indole-3-yl)methane

7 luoro-1H-indole-3-yl)methane (57, PSB-16671, EC50 41.3 nM).

8 A partial agonist molecule (-)-34 (EC50 (GTPgammaS); D2 = 21.6 (Emax = 27%) and D3 = 10.9 n

9 ervatives reduce proteinase activity by 50% (EC50) at a much lower concentration than their acceptabl

10 required to inhibit cellular growth by 50% (EC50) over 72 h decreased from 2 nM in regular Fe medium

11 AIMP (9; EC50 of 6.4 muM) and analogs 52-56 (EC50 of 0.4-4.7 muM), which contain one or two 2'-fluoro

12 nd 272mg.mL(-1)) that decreased after 7days (EC50 values: 248 and 314mg.mL(-1)).

13 onship modeling yielded analogues (i.e., 8n: EC50 = 0.06 muM, SI 500) that establish a platform for t

14 y cytokines: for the former, 3',3'-cAIMP (9; EC50 of 6.4 muM) and analogs 52-56 (EC50 of 0.4-4.7 muM)

15 lar potency and selectivity to salvinorin A (EC50 = 0.6 +/- 0.2 nM at kappa; >10000 nM at mu and delt

16 nd provided the highest antioxidant ability (EC50) (2481.44mg/kg).

17 ydrogen peroxide scavenger than gallic acid (EC50 838 mug/mL) and was equally strong as quercetin in

18 ) than their corresponding phosphonic acids (EC50 = 50-343 nM) in protection of cells from the viral

19 nM, D3 = 1.15 nM) and full agonist activity (EC50 (GTPgammaS); D2 = 3.23 and D3 = 1.41 nM) at both D2

20 ts with higher initial antioxidant activity (EC50 values: 214 and 272mg.mL(-1)) that decreased after

21 ed reasonable cell-based antiviral activity (EC50 = 10 muM).

22 ynthetic sample displayed anti-HIV activity (EC50 = 0.288 muM) in vitro.

23 resulted in a dramatic increase in activity (EC50 = 0.92 nM).

24 n), producing 57% of AVP's maximal activity (EC50 = 2.7 nM) and is not a V1a agonist up to a concentr

25 pound 15c displayed low micromolar activity (EC50 value of ca. 2 muM) and limited cytotoxic liability

26 amma9Vdelta2 T cells with moderate activity (EC50 = 26 muM).

27 selected for development based on activity (EC50 = 0.21 muM, selectivity index (SI) 40) and scaffold

28 -sulfonic acid) radical scavenging activity (EC50 17.52+/-0.46muM).

29 25% ex vivo, >50% in vivo) without affecting EC50 values.

30 ouse endothelial PECAM-1 with high affinity (EC50 1.5 and 3.8 nM, respectively), and codelivery induc

31 b, and 8c) are better anti-influenza agents (EC50 = 19-89 nM) than their corresponding phosphonic aci

32 0.63 nM) and highly selective kappa agonist (EC50 = 1.8 nM) selective for the periphery with dose-dep

33 selective mu-opioid receptor (MOR) agonist (EC50 = 1.2 nM, >8000 mu/kappa selectivity).

34 MP-2; 200 ng), 1 muM CGS21680 (A2AR agonist, EC50 = 160 nM), or 1 muM dipyridamole (EC50 = 32 nM) pro

35 y of nine compounds that were MC3R agonists (EC50 < 1000 nM) and MC4R antagonists (5.7 < pA2 < 7.8).

36 otubes treated with MR agonist (aldosterone; EC50 1.3 nM) or antagonist (spironolactone; IC50 1.6 nM)

37 ith near 100% maximum rescue activity and an EC50 of 0.032 muM.

38 10-fold increased corrector activity and an EC50 of 72.25 nM.

39 ing an EC50 of 4.69 muM against HIV-1 and an EC50 value of 0.5 muM against HBV, whereas completely la

40 compound 32, with a Kd value of 32 nM and an EC50 value of 0.67 muM in a surrogate cellular biomarker

41 With a K(+)/Na(+) selectivity of 9.8 and an EC50 value of 6.2 muM for K(+) ion, 5F8 is clearly among

42 nd impaired HIV-1 infection of T cells at an EC50 of 36 mum The identified lead compound, with a rela

43 -methyl compound (+)-15a, which displayed an EC50 of 23 nM in the calcium flux assay while showing no

44 Compound (+)-16b, which displayed an EC50 of 4.2 nM at 5-HT2C, no activity at 5-HT2B, and an

45 h an IC50 value of 14 nM, which displayed an EC50 value of 2.1 muM against H1N1 influenza virus in MD

46 with potent antiviral activity displaying an EC50 of 4.69 muM against HIV-1 and an EC50 value of 0.5

47 le-phenyl analogue RP-13s (IDX899) having an EC50 of 11 nM against the Y181C/K103N double mutant.

48 nse, the most potent compound (65) having an EC50 of 24 nM.

49 cent protein, in which compound 23 showed an EC50 of 11.3 muM.

50 he N-benzyl compound (+)-19, which showed an EC50 of 24 nM at the 5-HT2C receptor, is fully selective

51 eted ApoC-III by >80% in Hep3B cells with an EC50 2.9 nM.

52 elective D2 G-protein biased agonism with an EC50 in the subnanomolar range.

53 g activity in the RSV replicon assay with an EC50 of 0.15 muM.

54 ph3h disrupted A. fumigatus biofilms with an EC50 of 0.4 nM.

55 ed the highest antioxidant capacity, with an EC50 of 0.97mg/mL, and total flavonoids (44.7 epicatechi

56 m blood stage proliferation in vitro with an EC50 of 2.1 nM.

57 ted PARylation in a whole-cell assay with an EC50 of 2.51 nM and prevents proliferation of cancer cel

58 IFN-gamma in a dose-dependent manner with an EC50 of 250 nM.

59 decreased spontaneous contractility with an EC50 of 3.9 mM.

60 epidermal cancer stem cell invasion with an EC50 of 3.9 muM, representing a significant improvement

61 l)-NAADP was shown to release Ca(2+) with an EC50 of 31 muM and to compete with NAADP for receptor bi

62 hest concentration tested (200 muM), with an EC50 of 79 muM.

63 nductance regulator (CFTR) activator with an EC50 of approximately 200 nM and demonstrated its therap

64 cholesterol is found to be the best with an EC50 value of 0.44 muM.

65 2-fold at a concentration of 300 muM with an EC50 value of 159 muM, whereas no potentiation of the gl

66 in a concentration-dependent manner with an EC50 value of approximately 0.2 microM and maximal cGMP

67 as also quantitatively assessed, yielding an EC50 value that agrees well with conventional biochemica

68 e GC-A-8E resulted in the same Vmax, Km, and EC50 as the phosphorylated WT enzyme.

69 aximum effect at approximately 50 nmol/L and EC50 values for both cytokines of approximately 10 nmol/

70 tal phenolic content and decreased TBARS and EC50 of breakfast cereal (p<0.05).

71 design of a water stable synthetic antigen (EC50 2 nM).

72 d contrasting inflammatory responses to APN (EC50 5 microg/ml).

73 stimulation with 100 nm ACh ( approximately EC50), [Ca(2+)]i increased as V(m) hyperpolarized below

74 , we identified compound 7, a potent AR (ARE EC50 = 0.34 nM) and selective (N/C interaction EC50 = 12

75 Sensitivity (expressed as EC50 values) of sult2st3 and cyp2k22 gene expression ind

76 eptor internalization in a cell-based assay (EC50 = 0.05 muM), but has poor physical properties and m

77 a hippocampal slice electrophysiology assay (EC50, 165 nM).

78 aging plate reader (FLIPR) functional assay (EC50, 36 nM) and carbachol in a hippocampal slice electr

79 ency in the beta-arrestin recruitment assay (EC50 0.9 nM) compared with the G alphai-activation assay

80 le sclerosis, was equipotent in both assays (EC50 1.5 and 1.1 nM, respectively).

81 lioblastoma (GBM) cells and with astonishing EC50 value (38 pM) when loaded with a PI3K-mTOR inhibito

82 (-1)), Ag internalized by the algal cells at EC50 was similar (0.8 to 3.6 ngAg mL(-1)) for all AgNP t

83 er half-maximal effective concentration (AUC:EC50) of 108.6 is estimated to result in a negative GMI

84 ly, corrected pore-water-concentration-based EC50 values were calculated by equilibrium partitioning

85 units but not alpha subunits ((Z)beta3gamma2 EC50 value, 660 mum).

86 to explain the observed discrepancy between EC50 and Kd These results indicate that the mechanism by

87 We found that the relationship between EC50 and basal activity was well described by the concer

88 synthesis of antimalarial compound BRD3914 (EC50 = 15 nM) that hinges on a Pd-catalyzed, directed C(

89 activity against Trypanosoma brucei brucei (EC50 = 2.97 muM), thus being considered as a novel lead

90 two dioxin-like chemicals and the calculated EC50 values were concordant with domestic avian species

91 .6 nM), with greater therapeutic index (CC50/EC50 > 10000).

92 , corresponding to a therapeutic index (CC50/EC50) of approximately 100.

93 antileukemic activity against M9-ENL1 cells (EC50 = 0.57-2.90 muM) when compared to parthenolide (EC5

94 tent (biochemical IC50 = 0.002 muM, cellular EC50 = 0.032 muM) and selective inhibitor of EZH2.

95 linkages, are more potent than 2',3'-cGAMP (EC50 of 19.6 muM).

96 ndin (indomethacin) synthesis increased CGRP EC50 in both age groups.

97 O and prostaglandin synthesis increased CGRP EC50 in Young and Old MAs.

98 Ca(2+) influx through TRPA1 cation channels (EC50 ca. 200 nM), thereby explaining its ability to stim

99 at much lower exposures in the PB cocktail (EC50: 0.94 vs 6.06 mug/mL; P < 0.01), whereas the KW coc

100 ion of half-maximum effective concentration (EC50) across tested NPs (5.4 to 300 ngAg mL(-1)), Ag int

101 decrease in the 50% effective concentration (EC50) for activation through CD16, and a 38% decrease in

102 by 81.39a at a 50% effective concentration (EC50) of <0.01 to 4.9 mug/ml.

103 with a half maximal effective concentration (EC50) of 4 pM in vitro, representing an approximately 33

104 ar the half maximal effective concentration (EC50) of several microorganisms.

105 at ASM half-maximum effective concentration (EC50) or Vmax contribute to AHR in asthma, but, because

106 The half-maximal effective concentration (EC50) value of the time-resolved fluorescence resonance

107 ference between the effective concentration (EC50)-which is the dilution of sera that inhibits 50% in

108 PAR1 (effective half-maximal concentration (EC50), 8.4 +/- 1.1 versus 4.3 +/- 1.1 mum) and glycoprot

109 observed at the highest test concentration (EC50 > 3397 mumol L(-1) and >4892 mumol kg(-1) dry weigh

110 sensitivities (50% effective concentration [EC50]) of mutant and wild-type viruses to nine FDA-appro

111 ition (half maximal effective concentration [EC50]: 0.21 +/- 0.18 vs. 1.38 +/- 0.54 nM) and receptor

112 ivity half maximal effective concentration [(EC50): 4.5muM)].

113 ce, richness, and biomass at concentrations (EC50's ranged from 197.6 to 233.5 ng bifenthrin/g organi

114 , were toxic, with effective concentrations (EC50's) ranging from 0.5 to 5.5 muM.

115 ity of ILs, median effective concentrations (EC50) and critical micelle concentrations (CMC) were det

116 Half maximal effective concentrations (EC50) obtained after 10 min bioassay, 2.9, 1.0, 0.7 and

117 de of half-maximal effective concentrations (EC50) of nontarget invertebrates.

118 A549, MCF-7) with effective concentrations (EC50) typically below 5 nM, at least an order of magnitu

119 Mean half maximal inhibitory concentrations (EC50) for calcium, magnesium and zinc were 270+/-18, 253

120 al activity at low nanomolar concentrations (EC50 <500 nM) and low cytotoxicity in mammalian cells.

121 V-1(WT)), with 50% effective concentrations (EC50s) of 3.0 to 49 nM, and exhibited minimal cytotoxici

122 creases in the 50% effective concentrations [EC50s], respectively).

123 ng the frequency of OT induced contractions (EC50 = 350 nM) and increasing the OT EC50 from 0.081 nM

124 A new equation for converting EC50 into TEAC values and TEAC into EC50 is presented in

125 luded that the proposed model for converting EC50 into TEAC values and TEAC into EC50 values works pr

126 10 (MRS7232) esters enhanced binding at DAT (EC50 approximately 35 nM) and at the norepinephrine tran

127 The amphipod (7 day EC50s from 0.3 to 8.4 mug/L) was more sensitive than the

128 more sensitive than the insect nymph (7 day EC50s from 7.0 to 19.4 mug/L).

129 alpha3-beta4-alpha3-alpha3, LYPD6B decreased EC50 from 631 to 79 muM, reduced Imax by at least 59%, a

130 tivate the receptor with extremely different EC50 values of 1 pM and 50 nM, respectively.

131 hydro-2H-1,2,4-benzothiadiazine 1,1-dioxide, EC50 = 2.0 nM).

132 nist, EC50 = 160 nM), or 1 muM dipyridamole (EC50 = 32 nM) promoted bone regeneration.

133 re observed between the results of the DPPH (EC50=0.6-1105.3 mug/ml) and FRAP (0.1-8.5 mmol/g) assays

134 We showed that EA (EC50 = 15-30 uM) reduced parasite burden without showing

135 V for ERG3 (EC50 = 374 nM), -28 mV for EAG1 (EC50 = 1.18 muM), and more than -100 mV for ELK1 (EC50 =

136 ffort identified 4b (GS-5734) with anti-EBOV EC50 = 86 nM in macrophages as the clinical candidate.

137 pyridone amides that are highly efficacious (EC50 </= 100 nM) in attenuating infectivity across multi

138 = 1.18 muM), and more than -100 mV for ELK1 (EC50 = 197 nM) channels.

139 t activation of currents by -14 mV for ERG1 (EC50 = 414 nM), -20 mV for ERG3 (EC50 = 374 nM), -28 mV

140 V for ERG1 (EC50 = 414 nM), -20 mV for ERG3 (EC50 = 374 nM), -28 mV for EAG1 (EC50 = 1.18 muM), and m

141 c responses was xDP > xFP > waDP (e.g., EROD EC50s were lower for xDP compared to xFP and waDP).

142 Several compounds exhibited EC50 values below 10 nM against HCV infection, cytotoxic

143 ing several potent structures that exhibited EC50 values of <100 nM.

144 tudies revealed several compounds exhibiting EC50 values below 100 nM.

145 tween the calculated Kd and the experimental EC50 on HIV-infected cells confirmed the reliability of

146 with results from voltage-clamp experiments (EC50 values for alpha4beta3delta, alpha1beta3gamma2, and

147 ponses in a concentration-dependent fashion (EC50 = 11.4 +/- 2.9 muM, n = 3).

148 ated within the activity-toxicity framework: EC50 and LC50 values for all three taxa correlated gener

149 tamate (Glu) dependence, impact on NMDAR Glu EC50, and slowing of channel deactivation.

150 , and demonstrate an increase in the glycine EC50 value.

151 lling and the selective agonist GSK1016790A (EC50 approximately 33 nM) induced sustained transmembran

152 as further reduced (up to 7-fold higher 48-h EC50).

153 ty of the mixture with the experimental 96 h EC50 for the antibiotic mixture being 0.248 mumol/L comp

154 922-0796, F1609-0442, and F1750-0048) having EC50 (50% effective concentration) values of 4.8 +/- 2.3

155 potent and selective NS5A inhibitor of HCV (EC50 = 4.6 nM), with greater therapeutic index (CC50/EC5

156 ed by acetylcholine (ACh) and 15-fold higher EC50 with respect to ACh.

157 ), which is 16-fold selective for the hMC1R (EC50 = 4.5 nM) versus other melanocortin receptors.

158 These ligands showed activity (IC50/EC50 values) in the nanomolar range against purified PfS

159 tivation through CD16, and a 38% decrease in EC50 for NK group 2 member D (NKG2D)-mediated activation

160 A similar reduction in EC50 in daclatasvir-resistant mutants was achieved by co

161 increased PLX4720 sensitivity via shifts in EC50 and Hill slope metrics.

162 tration required for half-maximal induction (EC50) of GR-mediated gene expression by acting at a mini

163 negatively correlated with the Ca(2+) influx EC50.

164 was a stronger alpha-glucosidase inhibitor (EC50 2.9 mug/mL) than quercetin, with weak antiamylase a

165 4-phenylthiazole 18, a modest HCV inhibitor (EC50 = 9440 nM), a series of structurally related thiazo

166 1,2,3-triazole based infectivity inhibitors (EC50 </= 20 nM).

167 50 = 0.34 nM) and selective (N/C interaction EC50 = 1206 nM) modulator.

168 8 +/- 0.54 nM) and receptor internalization (EC50: 41.9 +/- 29.8 vs. 455 +/- 299 nM) than Cu-DA(IR800

169 nverting EC50 into TEAC values and TEAC into EC50 is presented in this paper.

170 nverting EC50 into TEAC values and TEAC into EC50 values works properly.

171 oratory and primary clinical HIV-1 isolates (EC50: 0.0014-0.0028 muM) with minimal cytotoxicity (CC50

172 o developed new ISRIB analogs, improving its EC50 to 600 pM in cell culture.

173 00 mg q8 h met or exceeded plasma kallikrein EC50 values throughout the dosing interval.

174 ctivity against five primary AML cell lines (EC50 = 0.76-7.3 muM).

175 id residues in Gag correlated with lopinavir EC50 (p < 0.01), of which 380 K and 389I showed modest i

176 IC50 ranging from 0.021 to 0.041 mg/mg, low EC50 from 0.92 to 1.78 mg/mg DPPH, high ARP values (56.1

177 ronic dosing of 48 showed a shift to a lower EC50 over 7 days.

178 g, whereas other coated AgNP displayed lower EC50 values.

179 etagogues, we found that PGE2 had the lowest EC50 value with regard to the induction of swelling of t

180 was significantly correlated with the lowest EC50 values for all the tested antioxidant activity assa

181 while it was virtually inactive at LXRalpha (EC50 = 14.51 muM).

182 on of influenza virus encoding wild-type M2 (EC50 = 2.3 microM), both 27: and tert-butyl 4'-(carbamim

183 N chemoreceptors in a dose-dependent manner (EC50 = 1.2 mum).

184 The various applications of the Deltalog(max/EC50) scale are described for each pharmacologic applica

185 ax) and the EC50 in the form of Deltalog(max/EC50).

186 Subsets were ranked by median EC50, and by whether subset EC50 was correlated with and

187 8-negative T-cells, the third highest median EC50, and significant correlations with frequencies of t

188 D28-negative T-cells with the highest median EC50, and the least differentiated, high-frequency Tc su

189 amide scaffold provided 17e, a potent (mGlu1 EC50 = 31.8 nM) and highly CNS penetrant (brain to plasm

190 selective agonist activity profile at mGlu2 (EC50 in the micromolar range), whereas 2c/2d were both s

191 ainst all four serotypes with low micromolar EC50 in cell-based assays.

192 t cell-mediated cytotoxicity (0.1-0.3 mug/ml EC50), and high tumor uptake in mouse xenografts.

193 ased MMP-13 expression dose [1-10 microg/ml (EC50 0.5-1 mug/ml)] and time (24-72 h) dependently, sign

194 t (Mps1 Ki = 0.09 +/- 0.02 nM; cellular Mps1 EC50 = 6.5 +/- 0.5 nM), highly selective, and orally act

195 y range from low micromolar to sub-nanomolar EC50, the most interesting compounds being 15 (0.97 nM),

196 nM, Ki hA1AR > 10000 nM, Ki hA3AR = 1487 nM, EC50 hA2BAR > 10000 nM).

197 onist discovered so far (Ki hA2AAR = 4.8 nM, EC50 hA2AAR = 4.9 nM, Ki hA1AR > 10000 nM, Ki hA3AR = 14

198 ency emerged as the significant correlate of EC50 for a given subset.

199 For the accurate determination of EC50, samples were incubated with DPPH radical for 1h be

200 The efficient concentration or EC50 value corresponds to the concentration of sample or

201 no effect on either channel-closing rate or EC50.

202 ctions (EC50 = 350 nM) and increasing the OT EC50 from 0.081 nM to 21 nM at a concentration of 600 nM

203 cued primary neurons subjected to oxidation, EC50 of 0.04 vs 19 muM for ADP.

204 5 versus 0.26 +/- 0.21 mug/ml) but not PAR4 (EC50, 50 +/- 1 versus 58 +/- 1 mum) signal transduction.

205 .57-2.90 muM) when compared to parthenolide (EC50 = 6.0) and showed potent antileukemic activity agai

206 antioxidant activity after the same period (EC50 values, 0days: 106mg.mL(-1); 7days: 48.7mg.mL(-1)),

207 rtuin 1 (SIRT1) levels in MCECs before PGE2 (EC50 approximately 2.5 mM) or CSE/IL-1beta exposure.

208 an memory T cells (subnanomolar to picomolar EC50 values).

209 structures, MAIT cell activation potencies (EC50 3-500 pM), and chemical stabilities are described.

210 With its excellent cellular potency (EC50 = 50 nM) and favorable pharmacokinetic properties (

211 21 displayed a significantly higher potency (EC50 = 40 +/- 4 muM) and a similar efficacy when compare

212 selectively and differentially the potency (EC50) and efficacy (E(max)) of hUII and URP ex vivo in a

213 Arg-(pI)DPhe-DNal(2')-NH2] were more potent (EC50 < 73 nM) than the melanocortin tetrapeptide Ac-His-

214 ad therapeutic window: identified as potent [EC50 < 0.02 mg/kg siRNA against FVII (siFVII)] in dose-r

215 submicromolar (sEH IC50 = 0.3 muM/PPARgamma EC50 = 0.3 muM) modulator 14c.

216 g 0.248 mumol/L compared to the CA predicted EC50 of 0.21 mumol/L.

217 enhanced >600-fold in the tris-POM prodrug (EC50 = 0.041 muM).

218 CH2)2-CONH2) displayed the desired profiles (EC50 (hGLP-2R) < 100 pM, CL in rat <0.3 mL/min/kg, selec

219 concentration-dependent expression profiles (EC50 = 6.5-30.0 nM) were characterized in detail.

220 he breast adenocarcinoma cell line, reaching EC50 values of 34.8 and 60.3 mug/ml for Willamette and M

221 tion associated with half-maximal reduction (EC50) of CD154 expression was calculated for 36 T-cell s

222 ibited viruses encoding M2(S31N) (respective EC50 = 18.0 and 1.5 microM).

223 centration approximately 15 times the drug's EC50 when treatment is given prophylactically starting a

224 o methoxamine being attenuated (mean +/- SEM EC50 decreased from 5.7 +/- 0.63 mum to 1.6 +/- 0.23 mum

225 to acetylcholine (ACh): agonist sensitivity (EC50), maximal agonist-induced current (Imax), and time

226 is capable of binding with high sensitivity (EC50 of 0.1 to 0.4 mug/mL depending on assay format) whi

227 the most potent H4R agonist in this series (EC50 11 nM; H4R vs H3R, >100-fold selectivity; H1R, H2R,

228 Twelve compounds showed EC50 values against T. brucei below 10 muM.

229 gly, all of these receptors had very similar EC50 values for GABA in the presence of the neurosteroid

230 ncentrations, as sigmoid fits showed smaller EC50 values and steeper slopes.

231 unds from this study exhibited submicromolar EC50 values against S31N-containing A/WSN/33 influenza v

232 ranked by median EC50, and by whether subset EC50 was correlated with and therefore could be represen

233 rough the use of different parameters (TEAC, EC50).

234 e inhibition occurred in standard ISO tests (EC50 values of 15-200 mg Pt/L), but also in a double-via

235 However, we observed that EC50 of ascorbate was at a similar level for cultured he

236 The EC50 calculated as a function of measured Agd concentrat

237 The EC50 dose-response curves for GCSF, GCSF-Fc and PEG-GCSF

238 The EC50 profiles for these unique analogues and their analo

239 The EC50 values of simeprevir in simeprevir-resistant mutant

240 The EC50(dNTP) values for SAMHD1 activation by dNTPs are in

241 eeks following the first administration, the EC50 GMT in the vaccine group was 2005 (95% CI, 1680-239

242 aximal response to the agonist (max) and the EC50 in the form of Deltalog(max/EC50).

243 s in the [(3)H]PT-1284 binding assay and the EC50 values of these ligands in a FLIPR functional poten

244 analysis, and in transactivation assays, the EC50 for TCDD was 23 nM, similar to X. laevis AHR1beta (

245 ments by cysteine-silver complexation at the EC50.

246 odel to examine the relationship between the EC50 for activation of the GABA type A (GABAA) receptor

247 cant variation was also observed between the EC50 values for the two assays, with robust levels of re

248 ld, whereas the R655C mutation decreased the EC50 5-fold, increased the Vmax 2.1-fold, and decreased

249 The A488P mutation decreased the EC50 5-fold, increased Vmax 2.6-fold, and decreased the

250 With no difference in efficacy, the EC50 of CGRP as a vasodilator was approximately 6-fold g

251 tions in SP, RT, and CVF highly exceeded the EC50 value (1.1 ng/mL).

252 Importantly, the EC50 values for NR ligands were consistent with those re

253 also resulted in predictable changes in the EC50 Finally, we altered the number of GABA-binding site

254 ant to foscarnet (a 1.9-fold increase in the EC50) and susceptible to ganciclovir.

255 utophosphorylation) by 6-fold and lowers the EC50 for Ca(2+)/CaM binding to activated eEF-2K (Thr-348

256 romolTrolox.g(-1) and by the DPPH method the EC50 was 85.68g.g(-1).

257 vity will result in identical effects on the EC50 We examined receptor activation by GABA while chang

258 CR4 agonists (CXCL12, ubiquitin) reduced the EC50 of the phenylephrine-induced blood pressure respons

259 This Kd is 50-100 times greater than the EC50 for Galphaq-mediated PLC-beta3 activation and for t

260 least an order of magnitude better than the EC50 values obtained for the clinically approved photose

261 equires its C2C and C2E domains and that the EC50 of such binding is in the low micromolar Ca(2+) ran

262 When the EC50 values for growth and reproduction are expressed ba

263 e, most of the ILs were as monomers when the EC50 was reached.

264 species to waterborne nickel (Ni), with the EC50 for the development of fully formed pluteus larvae

265 The EC50s of behavior for neurotoxic compounds were close to

266 versus 4.3 +/- 1.1 mum) and glycoprotein VI (EC50, 1.61 +/- 0.85 versus 0.26 +/- 0.21 mug/ml) but not

267 than PLTX in reducing HaCaT cells viability (EC50 = 1.1 x 10(-9) M vs 1.8 x 10(-11) M, MTT test) in a

268 WF (EC50 364 mug/mL) was a stronger hydrogen peroxide scaven

269 DPPH scavenging activity of WF (EC50 7.7 mug/mL) was weaker than quercetin.

270 f cancer cells carrying mutant BRCA1/2, with EC50 = 0.3 nM (MX-1) and 5 nM (Capan-1), respectively.

271 d CFTR activation potency compared to 4 with EC50 down to 21 nM and with greater metabolic stability.

272 sive stepping distance decreases 40-60% with EC50 values <100 nM propofol without an effect on veloci

273 ngeners that elicited alpha7 activation with EC50 values of 70 nM and Kd values for AChBP in a simila

274 hocyanidin A1 proved to be more active, with EC50 value for DPPH radical scavenging of 18.25 mug/mL a

275 with interesting antioxidant activities with EC50 values of up to 0.08 mg/L or values of TEAC of 0.67

276 xhibited excellent antioxidant activity with EC50 value of 16.43mug/mL.

277 ine exhibited good antioxidant activity with EC50 values of 36.05 and 33.35mug/mL respectively.

278 gregate size and specific surface area, with EC50 values for reproduction ranging from 4 to 29 mg Fe

279 srupted preformed A. fumigatus biofilms with EC50 values similar to those obtained for Sph3h In contr

280 rotease, integrase, and coreceptor CCR5 with EC50's ranging from 0.9 to 1.5 muM.

281 several leukemia and solid tumor cells with EC50 values as low as 280 nM, while they had negligible

282 ne CFTRact-K089 (1) that activated CFTR with EC50 approximately 250 nM, which when delivered topicall

283 lly activated CFTR chloride conductance with EC50 approximately 30 nM, without causing cAMP or calciu

284 1 gene was not significantly correlated with EC50 values.

285 the growth of P. falciparum in culture, with EC50 values below 400 nM.

286 , fully activated CFTR in cell cultures with EC50 approximately 250 nM and produced an approximately

287 otencies are enhanced compared with DCS with EC50 values in the low nanomolar range (1.7 nM at GluN1/

288 ant bactericidal activity was evidenced with EC50 values of 16.8+/-1.2muM for MTP1 and 109+/-7.0muM f

289 en production by human lung fibroblasts with EC50 of 150 nM.

290 phenylalanine (L-Phe) activated GPR139, with EC50 values in the 30- to 300-muM range, consistent with

291 inogens and their corresponding NBOMes, with EC50 values from the subnanomolar (NBOMes) to micromolar

292 exhibited exceptional potency profiles with EC50 values </=5 nM against major drug resistant HCV var

293 descending, LAD, occlusion in rabbits) with EC50 values of 190 and 8000 nM, respectively.

294 te at homomeric rat GluA2(Q)i receptors with EC50 values of 67.3 and 2.45 muM, respectively.

295 nes on F. candida in soil were similar, with EC50 values ranging from 2119 to 2559 mumol kg(-1) dry w

296 es (Pcs) and tetrapyrazinoporphyrazines with EC50 values as low as 5 nM (MCF-7 cells) for the best co

297 d HIV-1 97USSN54 (subtype A, R5-tropic) with EC50's of 0.6 and 0.9 muM, respectively.

298 inhibit SARS-CoV-2 replication in vitro with EC50 values of 0.008muM and 9.453 muM, respectively.

299 monotonic and inverted U-shaped pattern with EC50s that were approximately 10(5)-fold lower than thos

300 pinavir was observed across 20 viruses, with EC50s ranging 0.71-6.95 nM for atazanvir and 0.64-8.54 n