ライフサイエンスコーパス: EF hand

1 t accommodates one calcium ion in its fourth EF-hand.

2 sion of a single precursor lobe of a pair of EF-hand.

3 lin-like domain (CamLD) with calcium-binding EF hands.

4 th calcium-dependent and calcium-independent EF hands.

5 cs by disrupting beta-sheet coupling between EF hands.

6 tion where the PH domain moves away from the EF hands.

7 mboid protease that harbours calcium-binding EF-hands.

8 EF-2, EF-1 and allostery involving the four EF-hands.

9 are pollen-specific proteins containing two EF-hands.

10 th calcium-dependent and calcium-independent EF-hands.

11 influence the structure of the metal-binding EF-hands.

12 hands 1 and 4 as well as the linkers before EF hand 1 and the linkers between EF hands 4 and 5 and E

13 ation in combination with mass spectrometry, EF hands 1 and 4 as well as the linkers before EF hand 1

14 h formed by the surface of non-metal-binding EF-hand 1, the loop and the exiting helix of EF-hand 2,

15 nity for calcium ions of visinin-like domain EF-hands 1 and 2 (K(d) = 200 +/- 50 nM) was appropriate

16 the carrier and form a static unit, whereas EF-hands 1-3 form a calcium-responsive mobile unit.

17 EF hand 2 is highly accessible; however, EF hand 6 was d

18 Under the experimental conditions employed, EF hands 2 and 6, which are known not to bind calcium, w

19 EF-hand 1, the loop and the exiting helix of EF-hand 2, and the entering helix of EF-hand 3.

20 the flexibility of the hinge region between EF-hands 2 and 3 is required for placing GCAP1-regulated

21 FA titration experiments revealed that NCS-1 EF-hands 2-4 (EF2-4) contributed to binding with the D2R

22 um oscillations (~125-850 nM), while that of EF-hand 3 (K(d) </= 20 nM) implied occupancy at basal ca

23 elix of EF-hand 2, and the entering helix of EF-hand 3.

24 ha-helix, and the C-terminal lobe containing EF-hands 3 and 4 of VILIP-2 are sufficient to transfer i

25 ers before EF hand 1 and the linkers between EF hands 4 and 5 and EF hands 5 and 6 were identified as

26 ly reduced the affinity of Ca(2+) binding to EF-hand 4 and Ca(2+) sensitivity of the cyclase regulati

27 n the C-terminal portion of GCAP1, including EF-hand 4 and the helix connecting it with the N-termina

28 (or "tug") between the fatty acyl group and EF-hand 4 via the C-terminal helix that attenuates the e

29 y affected the affinity of Ca(2+) binding to EF-hand 4.

30 Unexpectedly, EF-hands 4-8 are involved in dimerization of the carrier

31 We established that EF hand-4 (EF-4) binds calcium first, followed by EF-3,

32 and the linkers between EF hands 4 and 5 and EF hands 5 and 6 were identified as regions of conformat

33 EF hand 2 is highly accessible; however, EF hand 6 was determined not to be surface accessible in

34 atory domain containing four calcium-binding EF-hands, a linker loop domain with an amphipathic alpha

35 lcium-regulated N-terminal domain with eight EF-hands, a mitochondrial carrier domain, and a C-termin

36 Interestingly, deleting the amino-terminal EF-hands activates proteolysis prematurely, while residu

37 hemotaxis was unaffected when Ca(2)+-binding EF hands and a conserved phosphorylation site of RGEF-1b

38 Recoverin has two functional EF hands and a myristoylated N terminus.

39 The lumenal EF-hand and SAM domains of STIM1 are believed to initiat

40 region responsible for the inhibition to the EF-hand and SH2 domains.

41 lasmic Na(V) C-terminal region including two EF-hands and an IQ motif, the Na(V) domain III-IV linker

42 Surprisingly, we find that the C-terminal EF-hands and coiled-coil domains do not contribute to PK

43 opathy or cancer that targeted the canonical EF hand, and the hydrophobic cleft yielded constitutivel

44 have a coiled-coil adaptor domain, a pair of EF-hands, and a Rab GTPase fused into a single polypepti

45 t PC2 channels unable to bind Ca(2+) via the EF-hand are inactive in single-channel planar lipid bila

46 to the kinase domain and two calcium-binding EF-hands at its N terminus.

47 al constraints imposed on the ligands by the EF-hand beta-scaffold.

48 but in evolutionarily earlier species, both EF hands bind calcium.

49 Atypically, the C-terminal EF-hand binding loop in Phl p 7 (from timothy grass) har

50 in the radius of gyration (R(g)) of the PC2 EF-hand by small angle x-ray scattering and significant

51 tions, ChREBP interacts with sorcin, a penta EF hand Ca(2+) binding protein, and is sequestered in th

52 model and analogous to crystal structures of EF hand Ca(2+)-binding proteins, two carboxylates (Asp-2

53 The BbCal1 sequence contained an EF-hand Ca(2+) binding domain and potential hydrophobic

54 f a hydrophobic cluster of residues near the EF-hand Ca(2+) binding sites.

55 diac gene delivery of parvalbumin (Parv), an EF-hand Ca(2+) buffer, has been studied as a therapeutic

56 We conclude that EF-hand Ca(2+) buffers regulate presynaptic IHC function

57 re members of the phylogenetically conserved EF-hand Ca(2+)-binding protein superfamily.

58 is a widely expressed, 22-kDa myristoylated EF-hand Ca(2+)-binding protein that shares a high degree

59 We previously reported that an EF-hand Ca(2+)-binding protein, neuronal calcium sensor

60 EF-hand Ca(2+)-binding proteins are thought to shape the

61 mologous proteins (CHP) are N-myristoylated, EF-hand Ca(2+)-binding proteins that regulate multiple c

62 ber of the neuronal calcium sensor family of EF-hand Ca(2+)-binding proteins.

63 , two paralogous, but functionally distinct, EF-hand Ca(2+)-binding proteins.

64 EF-hand Ca(2+)-binding sites were selectively inactivate

65 titution (ParvE101Q) at amino acid 12 of the EF-hand Ca(2+)/Mg(2+) binding loop disrupts bidentate Ca

66 We have identified the single EF-hand Ca2+-binding protein Ca2+-dependent modulator of

67 of the parvalbumin family, relative to other EF-hand CaBPs in cochlear and vestibular organs in the m

68 -induced calcium flash activates DUOX via an EF hand calcium-binding motif and thus triggers the prod

69 The S100 family of EF-hand calcium (Ca(2+))-binding proteins is essential f

70 Gene-level enrichment analysis identified EF-hand calcium binding domain 14 as a novel susceptibil

71 Tescalcin, an EF-hand calcium binding protein that regulates the Na(+)

72 The EF-hand calcium binding protein, parvalbumin, is a major

73 Secretagogin (SCGN), a hexa EF-hand calcium binding protein, plays key roles in insu

74 In the inner ear, EF-hand calcium buffers may play a significant role in h

75 nlike other reports of genetic disruption of EF-hand calcium buffers, deletion of oncomodulin (Ocm),

76 S100A6 is a small EF-hand calcium- and zinc-binding protein involved in th

77 Here, we identify EF-hand calcium-binding domain-containing protein 9 (EFC

78 ein was found to be nearly identical in both EF-hand calcium-binding domains (RMSD=0.19).

79 rvalbumin, calbindin, calretinin, N-terminal EF-hand calcium-binding protein 1, cholecystokinin, reel

80 Here we demonstrate that antibodies for the EF-hand calcium-binding protein, secretagogin, strongly

81 ion when compared with the apo states of the EF-hand calcium-binding proteins calmodulin, S100B, and

82 um-binding protein belonging to the group of EF-hand calcium-binding proteins.

83 h about 20 members in humans, is composed of EF-hand calcium-regulated proteins and is linked to a ra

84 and functional studies showed that the first EF hand can only bind calcium and be functionally active

85 We found that the EF-hand changes its conformation upon calcium binding, t

86 Ca(2+) and Mg(2+) binding to the individual EF-hands, characterize metal-induced conformational chan

87 ions of its other three constituent domains: EF-hand, coiled coil, and leucine zipper.

88 motility-signaling connections, since EFHC1 (EF-hand containing 1), a potential PACRG interaction par

89 We characterized an inorganic soluble EF-hand containing pyrophosphatase from T. cruzi (TcVSP)

90 Leucine zipper-EF-hand containing transmembrane protein 1 (Letm1), one

91 oupling proteins 2 and 3, the leucine zipper-EF-hand containing transmembrane protein 1 and the mitoc

92 ne protein 1-independent to a leucine zipper-EF-hand containing transmembrane protein 1- and mitochon

93 cium uniporter-dependent, but leucine zipper-EF-hand containing transmembrane protein 1-independent t

94 Its molecular components include the EF-hand-containing calcium-binding proteins mitochondria

95 LC25A24, and SLC25A25--represent a family of EF-hand-containing mitochondrial proteins that transport

96 The EF-hand-containing protein apoptosis-linked gene 2 (ALG-

97 to identify MICU1 (also known as CBARA1), an EF-hand-containing protein that serves as a putative reg

98 oupling protein 2 (UCP2), and leucine zipper EF-hand-containing transmembrane protein 1 (LETM1).

99 l Na/Ca exchanger) and LETM1 (leucine zipper-EF-hand-containing transmembrane protein 1) were propose

100 mitochondrial protein LETM1 (leucine zipper-EF-hand-containing transmembrane protein).

101 Calmodulin-like (CML) proteins are major EF-hand-containing, calcium (Ca(2+))-binding proteins wi

102 Mutations in the second EF-hand (D61N, D63N, D65N, and E72A) of S100B were used

103 a missense mutation occurs in the C-terminal EF hand domain (C2384Y).

104 tetrameric oligomeric state in which a fused EF hand domain arranges around the catalytic PPase domai

105 Here we asked which role EF hand domain containing 2 (EFhd2; Swiprosin-1) plays i

106 otion in PLC-beta by cross-linking it to the EF hand domain inhibits stimulation by Gbetagamma withou

107 Here we identified the small EF hand domain-containing protein Ca(2+) and integrin-bi

108 B1-interacting partners identified a related EF hand domain-containing protein, calcineurin B, the re

109 ail consists of three functional regions: an EF-hand domain (PC2-EF, 720-797), a flexible linker (798

110 postulate the relative reorientation of the EF-hand domain and the IQ domain as a possible conformat

111 ns in the cationic residues within the first EF-hand domain and the XY linker region dramatically red

112 the EF-hand motifs or deletion of the entire EF-hand domain did not affect the Ca(2+)-dependent activ

113 racterized the conformational changes in its EF-hand domain due to trimer formation.

114 We show that the binding of FHFs forces the EF-hand domain in a conformation that does not allow bin

115 servations highlight the central role of the EF-hand domain in modulating the binding mode of CaM.

116 Although the role of the EF-hand domain in RyR1 function has been studied extensi

117 functional significance of the corresponding EF-hand domain in RyR2.

118 ctural changes, suggesting a key role of the EF-hand domain in SEPN1 function.

119 These results indicate that, although the EF-hand domain is not required for RyR2 activation by cy

120 Downstream of the EF-hand domain lies a coiled-coil region, which is invol

121 On the other hand, deletion of the EF-hand domain markedly suppressed the luminal Ca(2+) ac

122 aracterized binding interactions between the EF-hand domain of alpha-actinin (Act-EF34) and peptides

123 Mutation of this EF-hand domain of junctate impaired its Ca(2+) binding a

124 Recombinant EF-hand domain of phospholipase C delta1 has a moderate

125 of the net positive charge within the first EF-hand domain of PLCzeta significantly alters in vivo C

126 r SOICR termination, whereas deletion of the EF-hand domain of RyR2 increased both the activation and

127 ntly, single amino acid substitutions in the EF-hand domain of SEPN1 identified as clinical variation

128 h an amino acid substitution in a functional EF-hand domain or a truncation of this motif by aberrant

129 The ZZ-type zinc finger and EF-hand domain protein 1 (ZZEF1) is a multidomain-contai

130 vels, and an immediately adjacent C-terminal EF-hand domain that directly binds Ca(2+).

131 Ca(2+) binding to the cytosolic EF-hand domain triggers conformational changes coupled t

132 Recently, the PLCdelta1 EF-hand domain was shown to bind to anionic phospholipid

133 a(2+) binding to its canonical binding site (EF-hand domain) of polycystin 2, a Ca(2+)-dependent chan

134 in the PC2 Cterm, there is a calcium-binding EF-hand domain, crucial for the calcium-dependent activi

135 2 has been shown to contain a Ca(2+)-binding EF-hand domain, the molecular basis of PC2 channel gatin

136 ure has the overall architecture of a paired EF-hand domain, the NaV1.2 C-terminal domain does not bi

137 As members of the EF-hand domain-containing neuronal Ca(2+) sensor protein

138 g site in the HPC2 Cterm, located within its EF-hand domain.

139 e intrinsic binding affinity of the isolated EF-hand domain.

140 cooperative Ca(2+)-binding sites within its EF-hand domain.

141 consisting of an IQ domain downstream of an EF-hand domain.

142 ows a binding mode that would clash with the EF-hand domain.

143 ations by binding this ion through a luminal EF-hand domain.

144 Lys-53, and Arg-57) within the mouse PLCzeta EF-hand domain.

145 in the SUPC2 Ccore relative to the isolated EF-hand domain.

146 Ectopic expression of SLC25A23 EF-hand-domain mutants exhibits a dominant-negative phen

147 SAXS data suggest structural flexibility in EF hand domains indicative of conformational plasticity

148 With the EF hand domains of Miro1 mutated to prevent Ca2+ binding

149 n-D28k is a calcium binding protein with six EF hand domains.

150 cTnC contains two EF-hand domains (the N and C domain of cTnC, cNTnC and c

151 substitution in a "hinge" region connecting EF-hand domains 2 and 3 in GCAP1 strongly interfered wit

152 S, and p.L151F), which are located on/around EF-hand domains 3 and 4, were confirmed as "pathogenic",

153 Deletions that disrupt core structure of the EF-hand domains abolish LMAN1 binding.

154 The EF-hand domains also mediate the interaction with FV and

155 Here we show that the C-terminal EF-hand domains are both necessary and sufficient for MC

156 fferential calcium binding affinities of the EF-hand domains compared with those of CaM suggest that

157 Calcium binding to the EF-hand domains of CP increases the Mn(II) affinity of t

158 Our results suggest that the EF-hand domains of MCFD2 contain separate binding sites

159 Furthermore, we show that the Ca(2+)-sensing EF-hand domains of Miro1 are important for regulating mi

160 ty to bind free calcium, via calcium binding EF-hand domains on the protein, or to bind calcium compl

161 We find that calcium binding to the EF-hand domains promotes autophosphorylation, which nega

162 ized to different structural elements of the EF-hand domains suggest that Ca(2+)-induced folding is i

163 sidues within the canonical and noncanonical EF-hand domains that can bind to multiple Ca(2+) ions.

164 terminal helix and the linker connecting two EF-hand domains).

165 ium binding and requires functionally intact EF-hand domains.

166 we show that two of the four calcium binding EF-hands dominate the FRET output of TN-XXL and that loc

167 decode Ca(2+) signals using four specialized EF-hands, each with specific, conserved traits.

168 function of the ABD and that the C-terminal EF hands (EF(34)) may bind to the linker that connects t

169 leckstrin homology (PH) domain and first two EF hands (EF1/2) are required for Rap1A activation and i

170 each containing one canonical Ca(2+)-binding EF-hand (EF1, EF4) and one structural EF-hand (EF2, EF3)

171 Mg(2+) binds to the first and third EF-hands (EF1 and EF3), and Ca(2+) binds to EF1, EF3, an

172 inding EF-hand (EF1, EF4) and one structural EF-hand (EF2, EF3).

173 t structural differences occur in the fourth EF-hand (EF4) and adjacent helical region (residues 164-

174 ecretagogin, a recently cloned member of the EF-hand family of calcium binding proteins, was localize

175 trins (CETN1-4) are ubiquitous and conserved EF-hand-family Ca(2+)-binding proteins associated with t

176 H/DX results the deuterium patterns for each EF hand for each state of the protein (apo through fully

177 HLH motif may have evolved from a canonical EF-hand found in invertebrate PC2 homologs.

178 bstitution that had been presumed to destroy EF-hand function, that of glutamine for glutamate at pos

179 minal actin-binding domain and COOH-terminal EF-hand-GAS2 domain.

180 We also found that the four EF-hands have distinguishing biophysical and structural

181 ubfamilies use different folds (coiled-coil, EF-hand, HOOK domain) and different surface contacts to

182 the four active sites for metal-ion binding (EF hands I, II, III, and IV) and the linker region (pept

183 agnesium cation that binds preferentially to EF-hand I of both isoforms.

184 conserved Phe residues at the -4 position in EF-hand III (F[-4]; Tyr(81)) and at the 13th position in

185 a decrease in the Ca(2+) binding affinity of EF-hands III and IV in OsCaM61.

186 variant, Rasgrp1(Anaef), with an ENU-mutated EF hand in the Rasgrp1 Ras guanine nucleotide exchange f

187 From these results, we suggest that the EF hands in the C-lobe are flexible and can be thought o

188 xt showed that coordination of calcium by an EF-hand in ELC1 and prebinding of MLC1 to the MyoA neck

189 STIM proteins contain an EF-hand in their N-termini that faces the lumen side of

190 different relative binding affinities of the EF-hands in the engineered fragment compared with the in

191 d N-terminal region (residues 1-99) and four EF-hands in two separate lobes.

192 ctive if the second (native) calcium-binding EF hand is intact.

193 We propose that the PC2 EF-hand is a Ca(2+) sensor required for channel gating.

194 (F[-4]; Tyr(81)) and at the 13th position in EF-hand IV (F[+13]; Phe(129)) of the C-terminal domain.

195 ge that is most prominent around the mutated EF-hand IV, as well as throughout the C-domain.

196 tion destabilises the native conformation of EF-hand IV, leading to a transient unfolding and dissoci

197 The MyoB-specific, single-lobe EF-hand light chain MlcB binds the sole IQ motif of MyoB

198 The structural integrity of the EF-hand like motif is essential for the 14-3-3 protein-m

199 Our data suggest that the EF-hand like motif-containing domain functions as the in

200 CaM)-binding IQ motif and the Ca(2+) sensing EF hand-like (EFL) motif in the carboxyl terminus of the

201 ormatics screening, we identified a putative EF-hand-like Ca(2+) binding motif in the carboxyl termin

202 modified beta-propeller fold and a distinct EF-hand-like calcium-binding site conserved in pathogens

203 l growth and has been reported to possess an EF-hand-like domain.

204 cated within the second RCK domain, forms an EF-hand-like motif and is strategically positioned close

205 discovered a characteristic calcium-binding EF-hand-like motif in NS2 and found that the calcium bin

206 icated that Ca(2+) binding to the N-terminal EF-hand-like motif promotes the activity of SPCA1a by fa

207 th1.14-3-3 complex and the importance of the EF-hand-like motif were investigated using site-directed

208 a at least partially depend on an N-terminal EF-hand-like motif, which is present only in the SPCA1a

209 talytic domain and the region containing the EF-hand-like motif, whose role in the activation of Nth1

210 The EF-hand-like motif-containing region forms a separate do

211 l, biophysical, and functional properties of EF-hand-like motifs in plant proteins.

212 itions of bound Mg(2+) and Mn(2+) within the EF-hand loops are similar to those of Ca(2+); however, t

213 inase-inducible domain peptides are based on EF-hand loops in which a structurally critical Glu12 res

214 ain does not bind Ca2+ through the canonical EF-hand loops, as evidenced by monitoring 1H,15N chemica

215 cture and the absence of Ca2+ binding by the EF-hand loops.

216 among its four Ca(2+)-binding sites, called EF-hands, may contribute to CaM's functional versatility

217 exhibits low homology (30-40%) to the pseudo-EF-hand mitochondrial SCaMCs buffering/solute transport

218 It lacks the EF hand motif characteristic of classical calpains but r

219 To test whether the EF hand motif is truly a calcium sensor controlling PC2

220 )/Mg(2+) binding affinities of parvalbumin's EF-hand motif alter function of cardiac myocytes.

221 Strategic design of new EF-hand motif domains to modulate intracellular Ca(2+) s

222 The Ca(2+)-binding EF-hand motif in Cdc24, the Cdc42 activator, was essenti

223 Furthermore, we identified a Ca(2+)-binding EF-hand motif in the ER-luminal region of junctate.

224 The Cdc24 EF-hand motif is therefore essential for polarity establ

225 Here, an EF-hand motif substitution that had been presumed to des

226 alpha-helix (H6) and the proximal structured EF-hand motif using transition-metal ion fluorescence re

227 if packed against a canonical Ca(2+)-binding EF-hand motif.

228 n of a putative intracellular Ca(2+)-binding EF-hand motif.

229 ity, we focused here on amino acid 12 of the EF-hand motif.

230 Here, we investigate whether these EF hand motifs serve as a calcium sensor responsible for

231 The C-terminal tail of hPC2 contains 2 EF hand motifs, but only the second binds calcium.

232 Ca(2+) binding domain encompassing a pair of EF-hand motifs (EF1 and EF2) in the skeletal muscle ryan

233 ) superfamily that harbors two high affinity EF-hand motifs and a C-terminal transmembrane domain.

234 y of Ca(2+) signaling in health and disease, EF-hand motifs designed to have new biological activitie

235 We also show that the EF-hand motifs of Miro mediate Ca(2+)-dependent arrest o

236 The two non-functional EF-hand motifs of MlcC pack together to form a globular

237 e investigate the effect of mutations in the EF-hand motifs on the Ca(2+) activation of RyR2.

238 We found that mutations in the EF-hand motifs or deletion of the entire EF-hand domain

239 of 10(8) and 10(4) M(-1), respectively, both EF-hand motifs qualify as Ca(2+)/Mg(2+) sites.

240 typical structure of CaMs, with two pairs of EF-hand motifs separated by a short linker domain.

241 of Medicago truncatula CCaMK, which contains EF-hand motifs, or this domain together with the autoinh

242 toyl group on a long N-terminal arm and four EF-hand motifs, three of which bind Ca2+, assembled into

243 tionary time, focusing primarily on the four EF-hand motifs.

244 Microinjection of the PLCzeta EF-hand mutants into mouse eggs enabled their Ca(2+) osc

245 ent compared with the intact odd-even paired EF-hands (nCaM and cCaM) in terms of changes in flexibil

246 Ca(2+) and Mg(2+) binding to the individual EF-hands, observed metal-induced conformational changes,

247 mine the order of Ca(2+) binding of the four EF hands of the protein.

248 Specifically, loss of calcium from the EF-hand of STIM1 that forms the key initiation point for

249 studies revealed that Ca(2+) binding to the EF-hands of hSCGN induces significant structural changes

250 we found that in the presence of Ca(2+) the EF-hands of human plastins bound to an immediately adjac

251 tial pathway that favors the calcium binding EF-hands of the C-terminal lobe over those of the N-term

252 g in the high-affinity Ca(2+)-binding sites (EF-hands) of the GUCA1A gene encoding guanylate cyclase-

253 ions suggests binding sites that are not an EF-hand or calmodulin model.

254 ane helices interacts intimately with paired EF-hands originating from the alpha-solenoid scaffold, s

255 elate with increased molecular motion in the EF-hand, possibly due to exchange between apo and Ca(2+)

256 as a point mutation in the calcineurin-like EF hand protein 1 (Chp1) gene that resulted in the produ

257 We found that the penta-EF-hand protein ALG-2 binds to the NH-terminal cytosolic

258 cover the IMAC, we have identified the small EF-hand protein calmodulin-like protein 4 (CALML4) as an

259 n neuronal calcium sensor-1, a multispecific EF-hand protein involved in neurotransmitter release and

260 Here, we studied the function of At-MICU, an EF-hand protein of Arabidopsis thaliana with homology to

261 that F1 TnC is a typical collapsed dumbbell EF-hand protein that accommodates one calcium ion in its

262 1) is an intrinsically disordered "imitator" EF-hand protein that increases the number of calcium car

263 This work focused on S100A11, a dimeric EF-hand protein with two hydrophobic target binding site

264 he absence of Ca(2+), DREAM/KChIP3 binds the EF-hand protein, calcineurin subunit-B.

265 e of Ca(2+), DREAM/KChIP3 interacts with the EF-hand protein, calmodulin (CaM).

266 teraction of DREAM/KChIP3 with the important EF-hand protein, CaM, and show that the interaction alte

267 t conformational change into a high-affinity EF-hand protein, furnishing a mechanism by which the pro

268 Parvalbumin (Parv), the archetypal EF-hand protein, is a high-affinity Ca(2+) buffer in man

269 onistic modulator (DREAM/KChIP3), a neuronal EF-hand protein, modulates pain, potassium channel activ

270 from Entamoeba histolytica, is a two-domain EF-hand protein.

271 Ca(2+) and Mg(2+) binding of calmodulin, an EF-hand protein.

272 nctions of the members of the S100 family of EF-hand proteins are modulated by calcium and, in a numb

273 EF-hand proteins are ubiquitous in cell signaling.

274 ff of calmodulin activity and possibly other EF-hand proteins at the resting levels of Ca(2+).

275 S100B is a member of the S100 subfamily of EF-hand proteins that has been implicated in malignant m

276 conductive channel while MICU1 and MICU2 are EF-hand proteins that regulate the channel activity in a

277 important of these "calcium sensors" are the EF-hand proteins.

278 nding the conformational dynamics of similar EF-hand proteins.

279 with a deletion of the entire N-terminal non-EF hand region still retains the LMAN1-binding function.

280 amino terminus, whereas the C-lobe binds an EF-hand region upstream of the IQ domain.

281 rgets CDPK2 to amylopectin stores, while the EF-hands regulate CDPK2 kinase activity in response to C

282 nal transmission from Ca(2+) to ABD2 through EF-hands remains to be established.

283 Those critical cationic EF-hand residues in PLCdelta1 are notably conserved in P

284 on of the Ca(2+)-binding residues within the EF hands resulted in a complete loss of PLS3 rescue.

285 and location of calcium-binding sites in the EF hand senses the concentration of calcium required for

286 This protein possesses a modified pseudo-EF-hand sequence at the C-terminal end which exhibits lo

287 d sequences within the putative PFMG1 pseudo-EF-hand sequence region.

288 tionic and hydrophobic residues in the first EF-hand sequence.

289 affect either the binding pocket affinity or EF-hand structure of the binding domain.

290 n protein export is centrin, a member of the EF-hand superfamily of Ca(2+)-binding proteins.

291 calcium binding proteins that belong to the EF-hand superfamily with diverse biological functions.

292 Calmodulin (CaM), a member of the EF-hand superfamily, regulates many aspects of cell func

293 ondrial inner membrane and has two canonical EF hands that are essential for its activity, indicating

294 determined the order of binding to the four EF hands to be III, IV, II, and I by extracting from the

295 Ca(2+) store depletion destabilized the two EF hands, triggering disassembly of the hydrophobic clef

296 abundant allergenic protein domain families (EF-hand, Tropomyosin, CAP, Profilin, Lipocalin, Trypsin-

297 dumbbell-shaped molecule that contains four EF hands (two in the N-lobe and two in the C-lobe) that

298 escence anisotropy (FA) and a panel of NCS-1 EF-hand variants to interrogate the interaction between

299 The EF hands were essential for PLS3 rescue of smn morphant

300 ding its myristoylation site, and the second EF-hand, which is inactive in Ca(2+) binding, are the ke