ライフサイエンスコーパス: EF hand domain

1 terminal helix and the linker connecting two EF-hand domains).

2 ations by binding this ion through a luminal EF-hand domain.

3 Lys-53, and Arg-57) within the mouse PLCzeta EF-hand domain.

4 in the SUPC2 Ccore relative to the isolated EF-hand domain.

5 g site in the HPC2 Cterm, located within its EF-hand domain.

6 e intrinsic binding affinity of the isolated EF-hand domain.

7 cooperative Ca(2+)-binding sites within its EF-hand domain.

8 consisting of an IQ domain downstream of an EF-hand domain.

9 but has no effect on calcium affinity of the EF-hand domain.

10 ows a binding mode that would clash with the EF-hand domain.

11 connecting the Ca2+-binding loops in the two-EF-hand domain.

12 g to an IQ motif immediately adjacent to the EF-hand domain.

13 ependence of the Ca2+-binding sites in a two-EF-hand domain.

14 or stabilizing the "open" conformation of an EF-hand domain.

15 +) binding sites across the beta-sheet of an EF-hand domain.

16 nstead required the pleckstrin homology (PH)-EF-hand domain.

17 n-D28k is a calcium binding protein with six EF hand domains.

18 duplication, and possess four Ca(2+)-binding EF hand domains.

19 by a central linker; each lobe contains two EF-hand domains.

20 cium-binding proteins, contains six putative EF-hand domains.

21 o GTPase domains flanking two Ca(2+)-binding EF-hand domains.

22 7 transmembrane domains and calcium-binding EF-hand domains.

23 ium binding and requires functionally intact EF-hand domains.

24 ked to the overall conformation of different EF-hand domains.

25 wo helix-loop-helix motifs characteristic of EF-hand domains.

26 dramatic departure from that of Ca(2+)-bound EF-hand domains.

27 rp-21 to the solution in a non-metal-binding EF-hand domain 1 that interacts with RetGC.

28 substitution in a "hinge" region connecting EF-hand domains 2 and 3 in GCAP1 strongly interfered wit

29 S, and p.L151F), which are located on/around EF-hand domains 3 and 4, were confirmed as "pathogenic",

30 Deletions that disrupt core structure of the EF-hand domains abolish LMAN1 binding.

31 fragment of PLC delta1 that encompasses the EF-hand domain also bound to micelles containing AA usin

32 The EF-hand domains also mediate the interaction with FV and

33 e novo heterozygous missense variants in the EF-hand domains also result in distinctive brain malform

34 ved lipids, and two salt bridges between the EF hand domain and the S2-S3 loop validated by disease-c

35 postulate the relative reorientation of the EF-hand domain and the IQ domain as a possible conformat

36 ns in the cationic residues within the first EF-hand domain and the XY linker region dramatically red

37 lar basis for the coupling of the intrinsic (EF-hand domain) and extrinsic (calmodulin) components of

38 tains a leader sequence, an LDLa domain, two EF-hand domains, and a conserved C-terminal HDEL sequenc

39 Here we show that the C-terminal EF-hand domains are both necessary and sufficient for MC

40 tetrameric oligomeric state in which a fused EF hand domain arranges around the catalytic PPase domai

41 calgranulins share conserved calcium-binding EF-hand domains, associate noncovalently as homodimers a

42 a trimer of calpain-3 dimers with six penta-EF-hand domains at its core.

43 eracts extensively with the carboxy-terminal EF-hand domain (C-lobe) of the partner protomer.

44 a missense mutation occurs in the C-terminal EF hand domain (C2384Y).

45 f these novel proteins contain known motifs; EF-hand domains (CGR11) and a ring-finger domain (CGR19)

46 fferential calcium binding affinities of the EF-hand domains compared with those of CaM suggest that

47 Here we asked which role EF hand domain containing 2 (EFhd2; Swiprosin-1) plays i

48 pair, span 40 kb within a novel transcript, EF-hand domain containing 2 (EFHC2).

49 Here we identified the small EF hand domain-containing protein Ca(2+) and integrin-bi

50 B1-interacting partners identified a related EF hand domain-containing protein, calcineurin B, the re

51 As members of the EF-hand domain-containing neuronal Ca(2+) sensor protein

52 in the PC2 Cterm, there is a calcium-binding EF-hand domain, crucial for the calcium-dependent activi

53 the EF-hand motifs or deletion of the entire EF-hand domain did not affect the Ca(2+)-dependent activ

54 racterized the conformational changes in its EF-hand domain due to trimer formation.

55 3 degrees rotation of helix 3 in the typical EF-hand domain (EF2) upon the addition of calcium.

56 at resembles the calcium-binding loop of the EF-hand domain found in many calcium-binding proteins.

57 k calcium affinity reported for the isolated EF-hand domain; high affinity binding is observed only i

58 We show that the binding of FHFs forces the EF-hand domain in a conformation that does not allow bin

59 servations highlight the central role of the EF-hand domain in modulating the binding mode of CaM.

60 inding of calcium to RGS3, as deletion of an EF-hand domain in RGS3 abolishes both the desensitizatio

61 Although the role of the EF-hand domain in RyR1 function has been studied extensi

62 functional significance of the corresponding EF-hand domain in RyR2.

63 ctural changes, suggesting a key role of the EF-hand domain in SEPN1 function.

64 ilon revealed previously unrecognized PH and EF-hand domains in the amino terminus.

65 an additional 60 residues C-terminal to the EF-hand domain, including the IQ motif that is central t

66 We find that calcium binding to the EF-hand domain increases NADPH dynamics, permitting elec

67 SAXS data suggest structural flexibility in EF hand domains indicative of conformational plasticity

68 otion in PLC-beta by cross-linking it to the EF hand domain inhibits stimulation by Gbetagamma withou

69 (2+) activating site and we propose that the EF hand domain is an inhibitory divalent cation sensor.

70 These results indicate that, although the EF-hand domain is not required for RyR2 activation by cy

71 The intrinsic EF-hand domain is shown here to interact with the IQ mot

72 A unique domain of CCAR1, the EF hand domain, is required for interaction with the U2A

73 Downstream of the EF-hand domain lies a coiled-coil region, which is invol

74 On the other hand, deletion of the EF-hand domain markedly suppressed the luminal Ca(2+) ac

75 Ectopic expression of SLC25A23 EF-hand-domain mutants exhibits a dominant-negative phen

76 With the EF hand domains of Miro1 mutated to prevent Ca2+ binding

77 aracterized binding interactions between the EF-hand domain of alpha-actinin (Act-EF34) and peptides

78 Mutation of this EF-hand domain of junctate impaired its Ca(2+) binding a

79 Recombinant EF-hand domain of phospholipase C delta1 has a moderate

80 ese results suggest that the function of the EF-hand domain of PLC delta1 is to bind lipid and to all

81 of the net positive charge within the first EF-hand domain of PLCzeta significantly alters in vivo C

82 r SOICR termination, whereas deletion of the EF-hand domain of RyR2 increased both the activation and

83 ntly, single amino acid substitutions in the EF-hand domain of SEPN1 identified as clinical variation

84 were maintained in the absence of the fourth EF-hand domain of the light chain, and were sensitive to

85 Two regions target the penta-EF-hand domains of calpain and the third occupies the su

86 teractions between the calcium-binding penta-EF-hand domains of CAPN1 or CAPN2 and CAPNS1.

87 Calcium binding to the EF-hand domains of CP increases the Mn(II) affinity of t

88 Our results suggest that the EF-hand domains of MCFD2 contain separate binding sites

89 Furthermore, we show that the Ca(2+)-sensing EF-hand domains of Miro1 are important for regulating mi

90 urbations observed here for residues in both EF-hand domains of S100B during Zn(2+) titrations could

91 a(2+) binding to its canonical binding site (EF-hand domain) of polycystin 2, a Ca(2+)-dependent chan

92 rin molecule contains four helix-loop-helix 'EF-hand' domains, of which three can bind calcium.

93 ty to bind free calcium, via calcium binding EF-hand domains on the protein, or to bind calcium compl

94 h an amino acid substitution in a functional EF-hand domain or a truncation of this motif by aberrant

95 ail consists of three functional regions: an EF-hand domain (PC2-EF, 720-797), a flexible linker (798

96 We find that calcium binding to the EF-hand domains promotes autophosphorylation, which nega

97 The ZZ-type zinc finger and EF-hand domain protein 1 (ZZEF1) is a multidomain-contai

98 existence of the four-helix bundle common to EF-hand domain proteins.

99 ion rates (k(off)) in both the C- and N-lobe EF-hand domains, respectively.

100 eptide binds between helices I and IV in the EF-hand domain, similar to the binding of target peptide

101 regulation of genes coding for proteins with EF-hand domain, such as RBOHD orthologs, and TF members.

102 ized to different structural elements of the EF-hand domains suggest that Ca(2+)-induced folding is i

103 vels, and an immediately adjacent C-terminal EF-hand domain that directly binds Ca(2+).

104 sidues within the canonical and noncanonical EF-hand domains that can bind to multiple Ca(2+) ions.

105 was used to predict 20 residues of the penta-EF-hand domains that contribute to heterodimerization.

106 cTnC contains two EF-hand domains (the N and C domain of cTnC, cNTnC and c

107 2 has been shown to contain a Ca(2+)-binding EF-hand domain, the molecular basis of PC2 channel gatin

108 ure has the overall architecture of a paired EF-hand domain, the NaV1.2 C-terminal domain does not bi

109 Ca(2+) binding to the cytosolic EF-hand domain triggers conformational changes coupled t

110 ned the solution structure of the C-terminal EF-hand domain using multidimensional heteronuclear NMR.

111 The binding of an IQ motif peptide to the EF-hand domain was characterized by isothermal titration

112 Recently, the PLCdelta1 EF-hand domain was shown to bind to anionic phospholipid

113 The functionality of Scarf EF-hand domains was assayed with a radioactive Ca2+-bind

114 pplying this assay to mutants in Tcb2's four EF hand domains, we show that D184 is the key calcium bi

115 drastically reduces calcium affinity of the EF-hand domain, whereas the Brugada mutation A1924T sign

116 mic reticulum membrane, where a Ca2+-binding EF-hand domain within the N-terminal of the protein lies