ライフサイエンスコーパス: ERAS

1 ERAS and ERAD are complementary, as simultaneous inactiv

2 ERAS and Pain Management CPGs were developed by a multid

3 ERAS compliance was assessed for 17 ERAS care elements,

4 ERAS implementation is independently associated with cos

5 ERAS in principle seems logical and safe for esophagecto

6 ERAS pathways have shown benefit in open pancreatoduoden

7 ERAS patients had shorter LOS (6 vs 8 days; P = 0.004) a

8 ERAS perioperative pathways have been recently applied t

9 ERAS programs have the potential to improve outcomes, bu

10 ERAS programs include perioperative interventions that w

11 ERAS programs use multimodal approaches to reduce compli

12 S of 4.4 d (95% CI: -6.8, -2.0 d; P < 0.001).ERAS patients consumed more protein due to the inclusion

13 ERAS compliance was assessed for 17 ERAS care elements, and the total compliance score for e

14 tial barriers and enablers to adoption of 18 ERAS interventions.

15 Implementation of 5 ERAS pathways (colorectal, liver, pancreas, gynecologic

16 Preoperative (86%) and intraoperative (73%) ERAS compliance exceeded postoperative compliance (38%).

17 udies presented data from 21 countries and 9 ERAS-guided surgical procedures with 15 (20.3%) having a

18 After ERAS implementation, there was increased minimally invas

19 erence-in-differences study before and after ERAS implementation in the target populations compared w

20 Although ERAS is associated with significant clinical outcome imp

21 Although ERAS is well established in colorectal surgery, experien

22 Although ERAS pathways improve perioperative outcomes through sta

23 on rates were also significantly lower among ERAS target populations after implementation.

24 An ERAS protocol in ambulatory anorectal surgery is feasibl

25 eam consisting of surgeons, anesthetists, an ERAS coordinator (often a nurse or a physician assistant

26 ) cycle was used to develop and implement an ERAS CPG at 15 academic hospitals in Canada.

27 cle can be used to successfully implement an ERAS program at multiple sites.

28 rst step toward successfully implementing an ERAS program.

29 If patients were managed in an ERAS pathway, the only significant reductions were in in

30 al surgery, particularly those managed in an ERAS setting.

31 dations for appropriateness to include in an ERAS SSC.

32 The final products of this work included an ERAS-specific SSC ready for implementation and a set of

33 Implementation included development of an ERAS guideline by a multidisciplinary group, communities

34 Following implementation of an ERAS pathway for lung resection, 123 consecutive patient

35 Implementation of an ERAS pathway was associated with effective post-operativ

36 Multicenter implementation of an ERAS program among patients undergoing elective colorect

37 ive staff supported the implementation of an ERAS program at the University of Toronto-affiliated hos

38 169) and POST (n = 126) implementation of an ERAS program containing all major ERAS Society guideline

39 qualitative comments was used to produce an ERAS-specific SSC.

40 t of patients, increasing compliance with an ERAS program and the use of laparoscopic surgery indepen

41 patients undergoing major surgery within an ERAS protocol.

42 In this meta-analysis, ERAS guidelines were associated with decreased hospital

43 in the pre-ERAS (July, 2014-July, 2015) and ERAS (July, 2015-July, 2016) period.

44 ion patients after conventional (n = 46) and ERAS (n = 69) care.

45 As a result, ERES and ERAS are functionally linked to create bidirectional tra

46 The dynamics of ERES and ERAS are indistinguishable, indicating that these struct

47 le conservation of the link between ERES and ERAS.

48 Six retrospective studies have assessed ERAS for esophagectomy, demonstrating favorable morbidit

49 rvices in Alberta, Canada, and had available ERAS and up to 1-year postsurgery administrative data.

50 tive care within NICUs allows for unit-based ERAS recommendations independent of the planned surgical

51 s (n = 907) undergoing lung resection before ERAS.

52 se regression) assessed associations between ERAS compliance (exposure) and postoperative outcomes.

53 nd reducing its incidence is central to both ERAS development and to the evidence-base for minimally

54 ltimodal analgesia approach for a colorectal ERAS pathway, most patients used less opioids while in t

55 are key components of successful colorectal ERAS and surgical site infection (SSI)-reduction program

56 e approach with ERAS pathway use, a combined ERAS + RPD approach was associated with reduced LOS and

57 entage of patients whose care met the common ERAS pathway care element criteria.

58 A major component ERAS pathways is opioid-sparing analgesia; however, the

59 Consequently, ERAS may have a significant role to play in improving ou

60 To date, ERAS has achieved significant benefit for patients and h

61 ensus (>=70% agreement) were used to develop ERAS-specific SSC prompts.

62 of either COPII or COPI components disrupts ERAS organization.

63 patient was a sum of the compliance for each ERAS care element.

64 Eleven ERAS components met criteria for development into an SSC

65 AS) protocols, but little work has evaluated ERAS in these cases.

66 irst focused comparative analysis evaluating ERAS outcomes in elderly patients undergoing emergency s

67 ere randomized clinical trials that examined ERAS-guided surgery compared with a control group and re

68 xpert discussion was used to produce a final ERAS-specific SSC that expands on the current WHO SSC to

69 major gynecologic oncology surgery following ERAS protocols with the care of 2 surgeons at an academi

70 Compliance for ERAS care elements varied widely, with the highest compl

71 n and collaboration, and better evidence for ERAS interventions.

72 oses both a challenge and an opportunity for ERAS.

73 surgical techniques, extent of gastrectomy, ERAS protocol implementation, and study design.

74 S and then produce COPI vesicles to generate ERAS.

75 The stakeholder- and expert-generated ERAS SSC could be adopted directly, or the recommendatio

76 ta strongly indicate that in quiescent HSCs, ERAS targets AKT via two distinct pathways driven by PI3

77 eams from hospitals are trained to implement ERAS processes.

78 iety that promotes, develops, and implements ERAS programs, publishes updated guidelines for many ope

79 o may inform future interventions to improve ERAS adoption and improve postoperative outcomes.

80 Increasing ERAS compliance was correlated with fewer complications

81 on and a set of recommendations to integrate ERAS elements into existing SSCs.

82 Snowball sampling recruited international ERAS users from multiple clinical specialties.

83 Patients were divided into: ERAS group (n = 67) and conventional group (n = 70), bas

84 Local ERAS teams from hospitals are trained to implement ERAS

85 had moderate compliance, 50 (19.5%) had low ERAS compliance, and 11 (4.3%) had high compliance.

86 tion of an ERAS program containing all major ERAS Society guidelines.

87 ements in clinical outcomes and cost, making ERAS an important example of value-based care applied to

88 The international, multicenter ERAS registry data, collected between November 2008 and

89 -scale implementation of a multidisciplinary ERAS program is feasible and effective in improving surg

90 A multifaceted ERAS program designed with a particular focus on periope

91 atients receiving conventional LSG care (non-ERAS) (n = 50) and those receiving ERAS protocol (n = 44

92 report any complication compared to the non-ERAS group (61% vs. 51%).

93 y (POD) zero compared to only 25% in the non-ERAS group.

94 vs. SAR46,040, p < 0.05) compared to the non-ERAS group.

95 ,362 vs 24,277; P = 0.001) compared with non-ERAS patients, whereas RPD was associated with decreased

96 Despite the known benefits of ERAS programs, uptake remains slow.

97 A combination of ERAS and robotic approach synergistically decreases hosp

98 is little direct evidence for components of ERAS, with much derived from nonesophageal thoracoabdomi

99 literature was searched for descriptions of ERAS in esophagectomy.

100 This demonstrates the effectiveness of ERAS in LSG and provides valuable insights for improving

101 Expression of ERAS in human melanoma cell lines conferred resistance t

102 mothripsis and leading to high expression of ERAS, a constitutively active RAS protein normally expre

103 5% CI, -27.7% to -1.5%; P = .03) in favor of ERAS, and readmission LOS was shorter by 1.7 days (95% C

104 th are protected by synergistic functions of ERAS and ERAD.

105 c regression was used to determine impact of ERAS and operative approach alone, or in combination (pr

106 The impact of ERAS on robotic pancreatoduodenectomy (RPD) is unknown.

107 ovement study suggest that implementation of ERAS across multiple pathways may improve health care pr

108 dies should aim to improve implementation of ERAS and increase the reach of the guidelines.

109 Implementation of ERAS in LSG improved postoperative outcomes, including s

110 Implementation of ERAS programs results in major improvements in clinical

111 Uptake and implementation of ERAS Society guidelines, together with ERAS-related rese

112 otably, in quiescent HSCs, the high level of ERAS protein correlates with the activation of AKT, STAT

113 The panel of ERAS experts included surgeons, anesthesiologists, and n

114 can therefore not be recommended as part of ERAS pathways in laparoscopic colorectal surgery.

115 Thus, in contrast to the reported role of ERAS in tumor cells associated with cell proliferation,

116 reoperation rates, suggesting the safety of ERAS implementation.

117 Prospective study of ERAS program, a multidisciplinary effort involving anest

118 preoperative anemia, and improving uptake of ERAS worldwide, including in low- and middle-income coun

119 The mean (SD) Reporting on ERAS Compliance, Outcomes, and Elements Research checkli

120 aluate 27 colorectal or gynecologic oncology ERAS recommendations for appropriateness to include in a

121 (pre-ERAS + OPD, pre-ERAS + RPD, ERAS + OPD, ERAS + RPD) on length of hospital stay (LOS) and overall

122 ble with a direct link from either FREIDA or ERAS.

123 de all 37 proposed prompts within the 3-part ERAS-specific SSC (used prior to induction of anesthesia

124 the enhanced recovery after surgery pathway (ERAS) has emerged as one of the best strategies to impro

125 , disease characteristics, and perioperative ERAS protocol compliance were assessed.

126 Our results place ERAS at the periphery of COPII-labeled ER export sites (

127 study compared a pre-ERAS cohort with a post-ERAS cohort.

128 Outcome measures for the pre-post-ERAS cohorts included length of stay (LOS), readmission,

129 rs; 526 [53.5%] female) and 6773 in the post-ERAS cohort (median [interquartile range] age, 62 [53-71

130 his quality improvement study compared a pre-ERAS cohort with a post-ERAS cohort.

131 ative approach alone, or in combination (pre-ERAS + OPD, pre-ERAS + RPD, ERAS + OPD, ERAS + RPD) on l

132 l cost compared with other combinations (pre-ERAS + OPD, pre-ERAS + RPD, ERAS + OPD).

133 with other combinations (pre-ERAS + OPD, pre-ERAS + RPD, ERAS + OPD).

134 lone, or in combination (pre-ERAS + OPD, pre-ERAS + RPD, ERAS + OPD, ERAS + RPD) on length of hospita

135 eview of consecutive RPD and OPDs in the pre-ERAS (July, 2014-July, 2015) and ERAS (July, 2015-July,

136 pated in the study, including 984 in the pre-ERAS cohort (median [interquartile range] age, 62 [53-71

137 port that embryonic stem cell-expressed RAS (ERAS) is specifically expressed in quiescent HSCs and do

138 of hospital stay (LOS) in patients receiving ERAS protocols and conventional care.We conducted a pros

139 care (non-ERAS) (n = 50) and those receiving ERAS protocol (n = 44) at International Medical Centre,

140 ng patients undergoing colorectal resection, ERAS implementation was associated with decreased rates

141 ombinations (pre-ERAS + OPD, pre-ERAS + RPD, ERAS + OPD).

142 combination (pre-ERAS + OPD, pre-ERAS + RPD, ERAS + OPD, ERAS + RPD) on length of hospital stay (LOS)

143 he Electronic Residency Application Service (ERAS) and Fellowship and Residency Electronic Interactiv

144 he Electronic Residency Application Service (ERAS) for the general surgery residency match and Gradua

145 referred to as ER-associated RNA silencing (ERAS), which acts together with ERAD to preserve ER home

146 ER arrival sites (ERAS) can be visualized by labeling COPI vesicle tethers

147 pportive of implementation of a standardized ERAS program and agreed that a standardized guideline ba

148 Induced by ER stress, ERAS is mediated by the Argonaute protein RDE-1/AGO2, is

149 7 patients recruited for the Early RA Study (ERAS), a multicenter, inception cohort study with follow

150 Components of successful ERAS programs were determined, and when not directly ava

151 Enhanced Recovery After Surgery (ERAS) aims to improve postoperative outcomes.

152 Enhanced Recovery After Surgery (ERAS) and various derivative ERPs have been successfully

153 Enhanced recovery after surgery (ERAS) colorectal programs have shown to be successful at

154 ion between enhanced recovery after surgery (ERAS) compliance and postoperative outcomes within head

155 Enhanced Recovery After Surgery (ERAS) guidelines and the World Health Organization Surgi

156 outcomes of enhanced recovery after surgery (ERAS) guidelines has not been completed.

157 Enhanced Recovery After Surgery (ERAS) is a global surgical quality improvement initiativ

158 Enhanced Recovery After Surgery (ERAS) is a paradigm shift in perioperative care, resulti

159 ffect of an enhanced recovery after surgery (ERAS) pathway on pain and opioid use following lung rese

160 omponent of Enhanced Recovery after Surgery (ERAS) pathways.

161 comes of an enhanced recovery after surgery (ERAS) program among 2 target populations: patients under

162 ption of an Enhanced Recovery after Surgery (ERAS) program by the multidisciplinary perioperative tea

163 ed Thoracic Enhanced Recovery After Surgery (ERAS) Program in an academic, quaternary-care center.

164 c review of enhanced recovery after surgery (ERAS) programs for esophagectomy and generate guidelines

165 Enhanced Recovery After Surgery (ERAS) protocols are evidence-based care bundles that red

166 Enhanced Recovery After Surgery (ERAS) protocols are well-established in elective surgery

167 Enhanced Recovery After Surgery (ERAS) protocols have been shown to increase recovery, de

168 Elements of enhanced recovery after surgery (ERAS) protocols have been successfully introduced in pat

169 inherent in enhanced recovery after surgery (ERAS) protocols, but little work has evaluated ERAS in t

170 dence-based Enhanced Recovery After Surgery (ERAS) recommendations.

171 y pathways [enhanced recovery after surgery (ERAS)].

172 This focused analysis provides evidence that ERAS protocols can be safely and effectively implemented

173 ll proliferation, our findings indicate that ERAS is important to maintain quiescence in HSCs.

174 We show that ERAS expression elicits a prosurvival signal associated

175 The ERAS (enhanced recovery after surgery) care has been sho

176 The ERAS group demonstrated significantly faster functional

177 The ERAS group had a lower incidence of postoperative Clavie

178 The ERAS group had a slightly shorter length of stay (2.05 d

179 The ERAS group had shorter LOS (P = 0.049) and fewer total i

180 The ERAS protocol consisted of preoperative, intraoperative,

181 The ERAS Society conducts structured implementation programs

182 The ERAS Society, an international nonprofit professional so

183 During this time of global crisis, the ERAS method of delivering care is required to take surge

184 ion, a greater percentage of patients in the ERAS group (58%) began oral intake than in the conventio

185 Average daily pain scores were lower in the ERAS group (median 1.3 vs 1.8, P = 0.004); however, this

186 sics used postoperatively was greater in the ERAS group (median 3 vs 2, P < 0.001).

187 ein intakes were significantly higher in the ERAS group due to the inclusion of oral nutrition supple

188 Remarkably, 100% of patients in the ERAS group were out-of-bed on postoperative day (POD) ze

189 ion in morphine milligram equivalents in the ERAS group whether tramadol was included (median 14.2 vs

190 Pain control was superior in the ERAS group, with consistently lower VAS scores and reduc

191 CI, 0.59-0.87; I2 = 78.6%; P < .001) in the ERAS group.

192 ics had significantly greater changes in the ERAS target populations after implementation compared wi

193 s used in 66% of controls and in none of the ERAS group (P < 0.001).

194 5-year follow-up, a higher percentage of the ERAS group did not report any complication compared to t

195 sed exponentially since the inception of the ERAS movement.

196 al intake, which is an essential part of the ERAS protocols, remains a matter of debate.

197 This is the first external validation of the ERAS Society thoracic guidelines; adoption by other cent

198 At 5-year follow-up, the ERAS group had a better prognosis with fewer complicatio

199 ch for patients both using and not using the ERAS pathway to reduce opioid consumption.

200 The 16 recommendations within this ERAS guideline are intended to be implemented within NIC

201 The Thoracic ERAS Program for lung resection reduced length of stay,

202 ndardized perioperative pathway according to ERAS principles.

203 al nurses, and neonatologists in addition to ERAS content and methodology experts.

204 Adherence to ERAS guidelines was measured by the percentage of patien

205 mprove health care practitioner adherence to ERAS guidelines, LOS, and readmission rates at a system

206 However, low adherence to ERAS items and high rates of protocol deviations are oft

207 terventions designed to improve adherence to ERAS protocols and underscoring the need for proactive c

208 al assigned ambulatory anorectal patients to ERAS (experimental) or routine care (surgeon's choice) f

209 resection cases performed in 2009 (prior to ERAS implementation), 2011, and 2012.

210 -0.90) for each 1-unit increase in the total ERAS compliance score.

211 cohort study included patients who underwent ERAS-guided HN major reconstructive surgery in Alberta,

212 We also found a novel fusion involving USP9X-ERAS formed by chromothripsis and leading to high expres

213 This USP9X-ERAS fusion appeared highly oncogenic on the basis of it

214 interval (CI) 0.16-0.67, P = 0.002), whereas ERAS was protective against high cost (OR 0.57, CI 0.33-

215 The SSC could be modified to align with ERAS recommendations for patients undergoing major surge

216 MVA, when combining operative approach with ERAS pathway use, a combined ERAS + RPD approach was ass

217 suggest that higher overall compliance with ERAS guidelines was associated with improved postoperati

218 on of ERAS Society guidelines, together with ERAS-related research, have increased exponentially sinc