ライフサイエンスコーパス: ES cell

1 Tet triple KO fibroblast derived from mouse ES cells.

2 ns between LIF-independent iOCT4 and control ES cells.

3 ty as well as the developmental potential of ES cells.

4 GC-like cells (PGCLCs) in EpiLCs, but not in ES cells.

5 g the levels of expression driven by CREs in ES cells.

6 ssion in murine Mesp1(Cre/+); Rosa26(EYFP/+) ES cells.

7 ntrol and L1CAM-deficient neurons from these ES cells.

8 ues the differentiation defects of aneuploid ES cells.

9 so contributes to the rapid proliferation of ES cells.

10 nt promoter genes were reduced in BAF250a KO ES cells.

11 3K79me2, H3K36me3, H3K9me3, and H4K20me3, in ES cells.

12 which are de-repressed in SUV420H2 knockout ES cells.

13 d promoters were bivalent in human and mouse ES cells.

14 0H2 in regulating the chromatin landscape of ES cells.

15 -scale chromatin interactions in pluripotent ES cells.

16 omote de novo methylation in differentiating ES cells.

17 ocesses that establish healthy pregnancy and ES cells.

18 essential for the proper differentiation of ES cells.

19 anisms in human prostate cancer versus mouse ES cells.

20 e of the most rapidly induced transcripts in ES cells.

21 l to the pluripotency and differentiation of ES cells.

22 rons derived from these conditionally mutant ES cells.

23 g wild-type Lsh but not the ATP mutant in KO ES cells.

24 enes or more) after a single transfection of ES cells.

25 ased targeting vectors introduced into mouse ES cells.

26 ensable for global gene expression in murine ES cells.

27 l-safe mechanism to prevent Xist activity in ES cells.

28 us 129SvJ/Mus castaneous (CAS) hybrid female ES cells.

29 ongation, and alternative splicing events in ES cells.

30 h may support the diverse mRNA repertoire in ES cells.

31 hment XCI during in vitro differentiation of ES cells.

32 a genome-wide basis in differentiating mouse ES cells.

33 regulated in Drosha- but not Dicer-deficient ES cells.

34 RNAPII elongation rates and RNA splicing in ES cells.

35 strongly suppressed in mouse embryonic stem (ES) cells.

36 hd9, Brg1 and Ep400 in mouse embryonic stem (ES) cells.

37 ration and survival of mouse embryonic stem (ES) cells.

38 ed their expression in mouse embryonic stem (ES) cells.

39 s of the HH pathway in mouse embryonic stem (ES) cells.

40 and TAD boundaries in mouse embryonic stem (ES) cells.

41 s in early mouse embryos and embryonic stem (ES) cells.

42 critical for self-renewal in embryonic stem (ES) cells.

43 expression programs in mouse embryonic stem (ES) cells.

44 but not in undifferentiated embryonic stem (ES) cells.

45 st RNA is unspliced in naive embryonic stem (ES) cells.

46 1, at bivalent loci in human embryonic stem (ES) cells.

47 We further demonstrate that in ES cells, 1) both RARgamma and RXRalpha are present at t

48 We found that TRF2 depletion in ES cells activates a totipotent-like two-cell-stage tran

49 some occupancy in KO ES cells compared to WT ES cells after differentiation.

50 The mouse ES cells also differentiate into Pax7(+) cells with sate

51 osome inactivation and XIST transcription in ES cells, also plays a role in maintenance of the inacti

52 ethodology that utilizes the differentiating ES cell and embryoid body system to define the modules a

53 analysis revealed that LIF-independent iOCT4 ES cells and control ES cells exhibit similar transcript

54 n, we purified native nucleosomes from mouse ES cells and detect that Suv39h1 and Suv39h2 exclusively

55 K27me3) of ChIP sequencing datasets in human ES cells and eight pairs in murine ES cells, and predict

56 de changes in NANOG-binding patterns between ES cells and EpiLCs, indicating epigenetic resetting of

57 otency-associated gene transcription both in ES cells and in differentiating embryoid bodies.

58 (TRIM28; also known as TIF1beta and KAP1) in ES cells and orchestrates retroviral silencing activity

59 se phenotypes were mimicked by SHANK3-edited ES cells and rescued by transduction with a Shank3 expre

60 Pausing can be induced directly in cultured ES cells and sustained for weeks without appreciable cel

61 sing quantitative live-cell imaging in mouse ES cells and tumor cells, we demonstrate that, although

62 9 trimethylation (H3K9me3) profiles in mouse ES cells and uncovered two distinct classes of SETDB1 bi

63 s involved in maintenance of embryonic stem (ES) cells and early embryonic development of the mouse.

64 trophoblast stem (TS) cells, embryonic stem (ES) cells and extra-embryonic endoderm stem (XEN) cells

65 omatin interactions in human embryonic stem (ES) cells and four human ES-cell-derived lineages, we un

66 lentiviral vector in murine embryonic stem (ES) cells and human inducible pluripotent stem (iPS) cel

67 We show that in embryonic stem (ES) cells and in some tissues, the Stra6 gene encodes tw

68 mpetent-able to give rise to embryonic stem (ES) cells and live, fertile mice.

69 L4 enzyme-dead knock-in (KI) embryonic stem (ES) cells and mice, which carry Y5477A/Y5523A/Y5563A mut

70 is expressed in pluripotent embryonic stem (ES) cells and regulates ES cell differentiation.

71 re malignant counterparts of embryonic stem (ES) cells and serve as useful models for investigating c

72 fferentiation of mouse embryonic stem cells (ES cells) and pre-implantation embryos towards primitive

73 Neurogenesis was reduced in BERKO ES cells, and oligodendrogliogenesis was enhanced.

74 in human ES cells and eight pairs in murine ES cells, and predicted high-confidence (HC) bivalent pr

75 precise control of the forces experienced by ES cells, and therefore provided at least one explanatio

76 promoter region are lost in embryonic stem (ES) cells, and ES-cloned embryos show RNF12-dependent Xi

77 o compare the gene expression profile of the ES cell- and adult progenitor-derived, GM-CSF-instructed

78 oduce the dramatic rearrangements underlying ES-cell- and PGC-specific transcriptional programs remai

79 In this protocol, mouse ES cells are aggregated in 96-well plates in medium cont

80 In the resulting chimeric animals, wild-type ES cells are the only source of mature adipocytes.

81 Mouse embryonic stem (ES) cells are a popular model system to study biological

82 Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from

83 infer that the functions of embryonic stem (ES) cells are most active initially and may gradually fa

84 the three-dimensional chromatin landscape of ES cells, as loss of SUV420H2 resulted in A/B compartmen

85 gramming in which repression of pre-existing ES cell-associated gene expression program is followed b

86 we found thatGli1andNanogare co-expressed in ES cells at high levels.

87 of BAF250a, a key regulatory subunit of the ES cell ATP-dependent Brahma-associated factor (BAF) chr

88 In this setting, we inquired how ES cells avoid the potentially deleterious consequences

89 udy presents a high-throughput and versatile ES cell-based mouse modeling platform that can be combin

90 ing involves labor-intensive embryonic stem (ES) cell-based gene targeting and tedious micromanipulat

91 such models are generated by embryonic stem (ES) cell-based targeted insertion, or pronuclear injecti

92 ly, we find the strongest gene clustering in ES cells between transcription factor genes that control

93 appear to retain "stem"-related functions of ES cells but exhibit unique signatures supporting roles

94 enes that are transcriptionally repressed in ES cells but ready to be activated in response to differ

95 ficient to support enhanced proliferation of ES cells, but not to maintain their undifferentiated phe

96 t characteristics similar to embryonic stem (ES) cells, but the genetic drivers underlying malignant

97 a disrupted the differentiation potential of ES cells by altering the expression timing of key develo

98 at ERK reversibly regulates transcription in ES cells by directly affecting enhancer activity without

99 fects of aneuploidy on mouse embryonic stem (ES) cells by generating a series of cell lines that each

100 HDR-mediated events in mouse embryonic stem (ES) cells by more than 20-fold through the use of co-inc

101 Conventional ES cells can be derived and maintained in vitro with med

102 Nonetheless, ES cells can seemingly acquire TS-like characteristics u

103 Mouse pluripotent embryonic stem (ES) cells can exist in distinct yet interchangeable epig

104 rogrammed STAP cells, unlike embryonic stem (ES) cells, can contribute to both embryonic and placenta

105 Here, we generated human embryonic stem (ES) cells carrying a conditional L1CAM loss-of-function

106 m, Aldh1l1(-/-) mice were generated using an ES cell clone (C57BL/6N background) from KOMP repository

107 alyzing two independent conditionally mutant ES cell clones, we found that deletion of L1CAM dramatic

108 ndings highlight a unique mechanism by which ES cells communicate with trophoblasts within the blasto

109 we found distinct nucleosome occupancy in KO ES cells compared to WT ES cells after differentiation.

110 In vitro data from ES cells confirmed that bexarotene-activated RXR affecte

111 The induction of telomere dysfunction in ES cells, consistent with somatic deletion of Trf2 (also

112 Despite this, ES cells consume high levels of exogenous glutamine when

113 Poised chromatin in ES cells contains both H3 Lys-4 trimethylation (H3K4me3)

114 Many of the transcription factors in ES cells control both host and retroviral genes coordina

115 ly similar to those of their embryonic stem (ES) cell counterparts, and both are typical of aneural m

116 on of the Romk1-specific first exon using an ES cell Cre-LoxP strategy and examined the renal phenoty

117 ntional serum plus LIF medium phenocopy male ES cells cultured in 2i/L.

118 Furthermore, we find that female ES cells cultured in conventional serum plus LIF medium

119 ts long-term LIF-independent self-renewal of ES cells cultured in media containing fetal bovine serum

120 , in which naive pluripotent embryonic stem (ES) cells cultured in basic fibroblast growth factor (bF

121 factor 4) plays an unappreciated role in the ES cell cycle by forming a complex with cyclin-Cdk1 and

122 educes endogenous H3K4 methylation levels in ES cells, decreases the protein stability of MLL3 and ML

123 RECQL5 and BLM has on mouse embryonic stem (ES) cells deleted for FANCB, a member of the FA core com

124 Map3k1(m) (PHD) ES cells demonstrate that the MEKK1 PHD controls p38 and

125 Here we demonstrate that embryonic stem (ES) cells derived from the ICM generate and shed microve

126 iPS cells and nuclear transfer ES cells (NT ES cells) derived by somatic cell nuclear transfer (SCNT

127 s stably maintained in embryonic stem cells (ES cells) derived from most embryos.

128 to steer directional differentiation because ES cell-derived cells are typically immature with impair

129 istent with this notion, we found that mouse ES cell-derived DCs (ES-DCs) represented less mature cel

130 etry, microscopic imaging, and RNA-Seq, that ES cell-derived macrophages responded to S. Typhimurium,

131 eproducible strategy to exponentially expand ES cell-derived megakaryocyte-erythroid progenitors that

132 ously using fetus-derived NPCs, infection of ES cell-derived pNSCs with HCMV was nonprogressive.

133 Embryonic Stem (ES) cell-derived EphrinB2(+) cells are enriched with hem

134 Here, human embryonic stem (ES) cell-derived neural progenitor cells, endothelial ce

135 We used human embryonic stem (ES) cell-derived primitive prerosette neural stem cells

136 Using ES-cell-derived human neurons, we show that ApoE secrete

137 man embryonic stem (ES) cells and four human ES-cell-derived lineages, we uncover extensive chromatin

138 Here, we generated human ES cells designed to conditionally express heterozygous

139 Cdkn2ab knockout mice, generated from 129P2 ES cells develop skin carcinomas.

140 We found that hemangiogenic progenitors from ES cells develop through intermediate gastrulation stage

141 In embryonic stem (ES) cells, developmental regulators have a characteristi

142 In ES cells, differentially expressed genes after perturbat

143 is one of the most rapidly induced genes in ES cell differentiation and it is the earliest expressed

144 We showed that ES cell differentiation induces selective alteration of

145 oth the mRNA and protein levels during mouse ES cell differentiation into SMCs (ESC-SMC differentiati

146 y Hoxa1-bound regions during early stages of ES cell differentiation into the neuro-ectoderm.

147 also improves, in addition to murine, human ES cell differentiation to blood cells.

148 de, dysregulated gene expression and delayed ES cell differentiation.

149 tent embryonic stem (ES) cells and regulates ES cell differentiation.

150 Both the MEKK1 PHD and TAB1 are critical for ES-cell differentiation and tumourigenesis.

151 We show that paused ES cells display a remarkable global suppression of tran

152 Drosha-deficient embryonic stem (ES) cells display genomic hypomethylation that is not ac

153 Trf2(-/-) (also known as Terf2) ES cells do not exhibit telomere fusions and can be expa

154 renewal of pluripotent mouse embryonic stem (ES) cells downstream of the cytokine leukemia inhibitory

155 Finally, in differentiating human ES cells, endodermal markers were more efficiently induc

156 st cancer model, using our novel female GEMM ES cell (ESC) pipeline.

157 derivation of somatic motoneurons (MNs) from ES cells (ESCs) after exposure to sonic hedgehog (SHH) a

158 from mutant p53-induced transformation using ES cells (ESCs) that express a conformational mutant of

159 Unlike in ES cells, Esrrb interacts in TS cells with the histone d

160 occupancy of pluripotency-associated loci in ES cells, Esrrb sustains the stemness of TS cells by dir

161 In response to the deletion of TRF2, ES cells exhibit a muted DNA damage response that is cha

162 Consequently, naive ES cells exhibit an elevated alphaKG to succinate ratio

163 Setdb1 ablated ES cells exhibit severe growth inhibition, which is not

164 t LIF-independent iOCT4 ES cells and control ES cells exhibit similar transcriptional programs relati

165 Haploid human ES cells exhibited typical pluripotent stem cell charact

166 , reproducibility and biological validity of ES cell experimentation.

167 eight genes including Braf, Mitf, and ERas (ES-cell expressed Ras) as candidate resistance genes.

168 ansferase SUV420H2 regulates embryonic stem (ES) cell fate by patterning the epigenetic landscape.

169 d using the data to deconvolute a mixture of ES cells, fibroblasts and hematopoietic progenitors into

170 uld aid efforts to generate autologous human ES cells for regenerative applications, as donated or di

171 Finally, we show that ES cells form T-loops independently of TRF2, which revea

172 Here, we engineered ES cells from WT mice to express a doxycycline-regulated

173 pulation has yielded haploid embryonic stem (ES) cells from several mammalian species, but haploid hu

174 gulates pivotal transcription factors in the ES cell gene regulatory network to sustain naive identit

175 w that exit from naive pluripotency in mouse ES cells generally occurs after a division.

176 Embryonic stem (ES) cells go though embryo-like cell cycles regulated by

177 Here we show that mouse embryonic stem (ES) cells grown under conditions that maintain naive plu

178 or expression of a functional RNAi-cassette, ES-cell handling, or screening for mice with the desired

179 several mammalian species, but haploid human ES cells have yet to be reported.

180 n vitro-differentiated human embryonic stem (ES) cells have provided unprecedented information on the

181 9(-/-) relative to Rad9(+/+) embryonic stem (ES) cells have reduced levels of Neil1 protein.

182 although short-term suppression of Mek1/2 in ES cells helps to maintain an ICM-like epigenetic state,

183 f a unique stem cell phenotype by both human ES cells (hESCs) and induced pluripotent stem cells (iPS

184 routes to generate nontransgenic naive human ES cells (hESCs).

185 he absence of proliferation (embryonic stem [ES] cell heterokaryons) or DNA replication (nuclear tran

186 Embryonic stem (ES) cells, however, characteristically suppress transcri

187 Extinction of ES cell identity in single cells is acute.

188 We propose that propagation of ES cell identity is not determined by a vast interactome

189 ed that Patz1 is required for maintenance of ES cell identity.

190 modification and primary differentiation of ES cells in 2i or 2i+LIF media without serum or undefine

191 we show that prolonged culture of male mouse ES cells in 2i/L results in irreversible epigenetic and

192 that contribute to the maintenance of mouse ES cells in a naive state.

193 19 is critical for proper differentiation of ES cells in collaboration with Rnf20.

194 s unclear how sustained propagation of naive ES cells in vitro affects their stability and functional

195 irst' allele and identify essential genes in ES cells, including the histone methyltransferase Setdb1

196 ption factors in common with embryonic stem (ES) cells, including OCT4 (encoded by Pou5f1), SOX2, NAN

197 urther show that injecting MVs isolated from ES cells into blastocysts results in an increase in thei

198 Here we differentiated mouse ES cells into macrophages in vitro and showed, through a

199 e genetically modified mouse embryonic stem (ES) cells into functional macrophages provides a potenti

200 monolayer cultures of mouse embryonic stem (ES) cells into PSM-like cells without the introduction o

201 ethod, genetically matched sets of human IVF ES cells, iPS cells and nuclear transfer ES cells (NT ES

202 Our strategy to generate null mutant mouse ES cells is applicable to thousands of genes and repurpo

203 The unique chromatin signature of ES cells is fundamental to the pluripotency and differen

204 Interestingly, enzyme-dead MLL4 protein in ES cells is highly unstable.

205 that using engineered human embryonic stem (ES) cells is a viable approach to studying disease-assoc

206 ES cells lacking all three MTA proteins exhibit complete

207 ization both in the inducible Xist transgene ES cell line and in normal XX somatic cells.

208 cing of EC cell lines and their nonmalignant ES cell line counterparts.

209 We constructed a homozygous mutant mouse ES cell line in the Traf2 gene that is known to play a r

210 We have therefore generated an ES cell line in which Hdac1 and Hdac2 can be inactivated

211 Using this ES cell line, we observed that the first primitive eryth

212 operties, we used a modified embryonic stem (ES) cell line that emulates the early embryonic demethyl

213 engineered a new transgenic embryonic stem (ES) cell line, where eGFP expression is driven by the re

214 ndrial localization of MRP-1 was examined in ES cell lines by differential centrifugation and membran

215 However, some ES cell lines demonstrated gradual loss of donor mtDNA a

216 es in an allele-specific manner using hybrid ES cell lines from reciprocal crosses between C57BL/6J a

217 alysed a collection of human parthenogenetic ES cell lines originating from haploid oocytes, leading

218 differentiation competence is more common in ES cell lines than in induced pluripotent stem cell line

219 uccessful isolation and maintenance of human ES cell lines with a normal haploid karyotype.

220 n in conditional-ready IKMC 'knockout-first' ES cell lines.

221 ogenic SHANK3 knockout human embryonic stem (ES) cell lines.

222 ) drives TE-like transcriptional programs in ES cells, maintains trophoblast stem (TS) cell self-rene

223 phectoderm (TE) lineage by repression of the ES cell master regulator Oct4 or activation of the TE ma

224 Like Mll4 knockout ES cells, Mll4(KI/KI) ES cells show reduced levels of H3

225 ring the onset of Hox gene expression in the ES cell model and during body segment identity specifica

226 IVF ES cells, iPS cells and nuclear transfer ES cells (NT ES cells) derived by somatic cell nuclear t

227 ot mutually exclusive within embryonic stem (ES) cell NuRD and, despite subtle differences in chromat

228 Fibers derived from ES cells of mdx mice exhibit an abnormal branched phenot

229 We found a strong dependency of TRF2-null ES cells on the telomere-associated protein POT1B and on

230 dress this issue, we cultured Ewing sarcoma (ES) cells on electrospun poly(epsilon-caprolactone) 3D s

231 ion mouse embryos, or by conversion of mouse ES cells or induced pluripotent stem (iPS) cells reprogr

232 d that co-culture of wild-type and aneuploid ES cells or supplementation with extracellular BMP4 resc

233 IalphaI is not produced by the ES cells per se but is added to the cells via the cell c

234 nd PRC2 reveals a novel mechanism underlying ES cell pluripotency and differentiation regulation.

235 aling in a LIF-independent manner to promote ES cell pluripotency and self-renewal.

236 expression patterns can serve as markers of ES cell pluripotency.

237 Embryonic stem (ES) cell pluripotency is governed by OCT4-centric transc

238 pose that after the dissolution of the naive ES-cell pluripotency network during establishment of Epi

239 The ES cell population behaves asynchronously.

240 ese functions, we used mouse embryonic stem (ES) cells, primary neurons, and APOE3 and APOE4 mice tre

241 gene profiles in multiple SCC cell lines to ES cell profiles and determined that SOX2 binds to disti

242 more, we found that a PKA inhibitor impaired ES cell proliferation, tumor growth and metastasis, whic

243 In contrast, pluripotent embryonic stem (ES) cells represent an inexhaustible source for DC produ

244 Although haploid human ES cells resembled their diploid counterparts, they also

245 on of Tet1 and Tet2 in mouse embryonic stem (ES) cells results in an apparent loss of H3K27me3 at biv

246 Moreover, LIF-independent iOCT4 ES cells retain the capacity to differentiate in vitro a

247 dx2-eGFP cells compared with embryonic stem (ES) cells reveal that they appear to retain "stem"-relat

248 Transcriptome sequencing of the Ctcfl ES cells revealed 14 genes deregulated by Ctcfl expressi

249 mitive endoderm, and inhibiting ERK supports ES cell self-renewal(1).

250 SALL4, a gene involved in the maintenance of ES cell self-renewal, is aberrantly expressed in 47.7% o

251 critical role in controlling embryonic stem (ES) cell self-renewal and pluripotency.

252 ription factor implicated in embryonic stem (ES) cell self-renewal, yet its knockout causes intrauter

253 ith cell-permeable alphaKG directly supports ES-cell self-renewal while cell-permeable succinate prom

254 is study demonstrates shear stress-dependent ES cell sensitivity to dalotuzumab, highlighting the imp

255 Aggressive cancers and embryonic stem (ES) cells share a common gene expression signature.

256 Like Mll4 knockout ES cells, Mll4(KI/KI) ES cells show reduced levels of H3K4me1/2.

257 changes using inducible CDX2 embryonic stem (ES) cells, so that we could predict which CDX2-bound gen

258 However, it is not known whether there are ES cell-specific mechanisms regulating mitotic fidelity.

259 enced by a large complex bound to DNA by the ES cell-specific zinc-finger protein ZFP809.

260 Cells newly departed from the ES cell state display features of early post-implantatio

261 The human naive ES cell state has eluded derivation without the use of t

262 drive their own expression and maintain the ES cell state; if their binding is lost, the ability to

263 ES cell telomeres devoid of TRF2 instead activate an att

264 e Ctcfl transgene reproduce the phenotype in ES cell-tetraploid chimeras.

265 Embryonic stem (ES) cells that have the remarkable capability to differe

266 duces a naive state in mouse embryonic stem (ES) cells that resembles the inner cell mass (ICM) of th

267 se model cell line and mouse embryonic stem (ES) cells that this library can be used for genetic resc

268 e all-trans-retinoic acid (RA)-responsive in ES cells, the downstream promoter contains a half-site R

269 In differentiating ES cells, the presence of NANOG reduces the transcriptio

270 In other stem cells, such as embryonic stem (ES) cells, the role of division remains unclear.

271 used successfully in murine embryonic stem (ES) cells, there remain a set of nearly two thousand gen

272 2 and NANOG promote the pluripotent state in ES cells, they show contrasting roles in EpiLCs, as Sox2

273 sequencing of in vitro-differentiated mouse ES cells to capture the continuous developmental process

274 extensive demethylation, we subjected mouse ES cells to chemically defined hypomethylating culture c

275 n a rate-dependent manner the sensitivity of ES cells to IGF-1R inhibitor dalotuzumab (MK-0646) and s

276 s, cohesin depletion enhanced the ability of ES cells to initiate somatic cell reprogramming in heter

277 a for the in vitro differentiation of murine ES cells to macrophages and cardiomyocytes, with dynamic

278 states are vital for the differentiation of ES cells to multipotent stem cells, little is known rega

279 cilitate cell differentiation increases from ES cells to terminally differentiated cells.

280 the differentiation of mouse embryonic stem (ES) cells to both primitive and definitive haematopoieti

281 The power of mouse embryonic stem (ES) cells to colonise the developing embryo has revoluti

282 this link, we have used NOD embryonic stem (ES) cells to generate a novel NOD transgenic line with t

283 mes at the edge of NFRs, where they regulate ES cell transcriptional programs.

284 Dnmt3a/b deletion retards ES cell transition, correlating with delayed Nanog promo

285 in from the inner cell mass, embryonic stem (ES) cells undergo differentiation to the trophectoderm (

286 We investigated whether mouse ES cells undergoing largely undirected neocortical diffe

287 mparison to more differentiated cells, naive ES cells utilize both glucose and glutamine catabolism t

288 However, by assaying thousands of ES cells, we identify a spectrum of subpopulations defin

289 In Oga KO mouse ES cells, we observed pronounced changes in expression o

290 t control this unique DNA damage response in ES cells, we performed a CRISPR-Cas9-knockout screen.

291 Using mouse Embryonic Stem (ES) cells, we show that the TF CTCF displaces nucleosome

292 equired for Neil1 protein stability in mouse ES cells, whereas it regulates NEIL1 transcription in th

293 ablish the poised chromatin configuration in ES cells, which is essential for the proper differentiat

294 d c-Myc (Myc) expression in cohesin-depleted ES cells, which promoted DNA replication-dependent repro

295 that uses the immense regenerative power of ES cells while avoiding the risks associated with direct

296 ncreases the level of global H2Bub1 in mouse ES cells, while down-regulation of Fbxl19 reduces the le

297 We expect that haploid human ES cells will provide novel means for studying human fun

298 i-MEFs) derived from DNA-hypomethylated 2i/L ES cells with genetic ablation of Dnmt3a or Dnmt3b.

299 Here we generated mouse embryonic stem (ES) cells with a constitutive endogenous Nf1 exon 23a in

300 Embryonic stem (ES) cells with the Ctcfl transgene reproduce the phenoty