ライフサイエンスコーパス: ET

1 ET and BLT profiles could clearly show their diagnostic

2 ET of VI-SO-MC interfaces demonstrated that these compar

3 ET showed a higher proportion of cytokine-producing ENV-

4 ET(A) receptor antagonism markedly increased leg blood f

5 ET-1 has been shown to promote degeneration of optic ner

6 ET-1 signaling therefore presents a potential new therap

7 ET-1 treatment significantly decreased protein expressio

8 injection of vasoconstrictive endothelin-1 (ET-1) along with Abeta toxicity on CNS pathogenesis; dri

9 Endothelin-1 (ET-1) is a vasoactive peptide that is elevated in aqueou

10 itric oxide and downregulating endothelin-1 (ET-1) production, has been implicated in IUGR.

11 giotensin II, aldosterone, and endothelin-1 (ET-1) that mediate the immediate benefit of increased ki

12 Here, we report that Endothelin-1 (ET-1), a molecular component of the postnatal SVZ, promo

13 In Experiment 2, we compared 10 ET participants with 10 HC to determine whether we could

14 uring exercise with either saline or BQ-123 (ET(A) receptor antagonist) infusion following a 2-week w

15 We identified 2 ET patients harboring double mutations in cis in MPL, na

16 ession and other changes, including system-2 ET production.

17 n inability to induce autocatalytic system-2 ET synthesis, a characteristic feature of climacteric ri

18 n familial ET cases and controls, although 4 ET patients carried 47 to 53 "intermediate" repeats.

19 s developed over a hand motion dataset of 81 ET and PD patients collected systematically in a movemen

20 f endothelin-1, acting through endothelin A (ET(A) ) receptors, in modulating the central and periphe

21 rtner recognition and formation of an active ET complex for CYP102A1 catalysis.

22 functioned in conjunction with the adjacent ET domain to impart BRD2-like activity onto BRD4S.

23 ors by inhibiting ET(A)R with macitentan, an ET(A)R antagonist approved for treatment of pulmonary hy

24 ive against uncoupled turnover or provide an ET pathway to the active site with substrate bound.

25 r >1 decade; one with 90 repeats remained an ET phenotype that did not evolve after 40 years, whereas

26 these PCET systems, as well as the analogous ET systems, are studied with microsecond molecular dynam

27 ed by the PCET systems than by the analogous ET systems.

28 s levels of angiotensin II, aldosterone, and ET-1; reduces ammoniagenesis; and diminishes inflammatio

29 he competing factors of enzyme catalysis and ET efficiency that may arise when complex enzyme reactio

30 First, ET(DBS) and ET exhibited greater dysmetria than HC and dysmetria did

31 pling between environmental fluctuations and ET reactions.

32 nicotine-induced increases in NGF, FN1, and ET-1 in LFs.

33 t to recapitulate increases in NGF, FN1, and ET-1, whereas treatment with a miR-98 mimic significantl

34 nicotine-induced increases in NGF, FN1, and ET-1.

35 f intoxination further confirmed that LT and ET could diffuse rapidly in the circulation, independent

36 that combination treatment of macitentan and ET(B)R gene therapy inhibits invasion, but not prolifera

37 in patients, we hypothesize that ET(A)R and ET(B)R play dichotomous roles in oral carcinogenesis and

38 the endothelin A and B receptors (ET(A)R and ET(B)R).

39 These results support a model where RIN and ET, via ERFs, are required for full expression of ripeni

40 ) excretion, gastrointestinal tolerance, and ET-related symptoms were also investigated.

41 ), endothelin-1 (EDN1, herein referred to as ET-1), and collagen (COL1A1 and COL3A1) were measured in

42 - unclarified juices and purees, as well as ET retention in pomace.

43 BchNB that drives sequential and asymmetric ET.

44 ck protein HSP90 enhances wound responses at ET by increasing the accumulation of the JA receptor, CO

45 y insect herbivory or mechanical wounding at ET resulted in COI1-dependent stomatal closure, leading

46 velopments have been made in the design of B-ETs in the last five years or so.

47 f further development prospects related to B-ETs should contribute to the systematisation and expansi

48 ing to the group of bioelectronic tongues (B-ETs) have been designed.

49 orrelation to sap flow-based T than EC-based ET.

50 Biological ET often occurs simultaneously with proton transfer (PT)

51 ctions are implicated in numerous biological ET pathways.

52 n of heme molecules in long-range biological ET.

53 mplications for how we understand biological ET.

54 Troglitazone blunted ET-1-induced contraction of UtA in hypoxic and normoxic

55 ory, and 52 probands from well-characterized ET pedigrees) and 200 controls and identified pathogenic

56 (ET) takes place across proteins with common ET pathways of several nanometers.

57 ) or cyclic elevated temperature conditions (ET; 28 to 33 degrees C; n = 8) from d40 to d60 of gestat

58 En face corneal ET and BLT maps with a diameter of 11 mm were computed.

59 Cryo-ET reveals how the shape of the helical membrane tube ar

60 Cryo-ET will ultimately reveal the inner workings of a cell a

61 he targeted fabrication of lamellae and cryo-ET imaging.

62 es structural biology and cell biology, cryo-ET is indispensable for structural cell biology-the stud

63 ctural details that were not visible by cryo-ET alone.

64 predicted by smFRET was not observed by cryo-ET, potentially owing to AT-2 inactivation.

65 e particles with blebs were examined by cryo-ET.

66 raging (SA) in electron cryotomography (cryo-ET).

67 method called electron cryotomography (cryo-ET).

68 milling and critical considerations for cryo-ET data acquisition of the lamellae.

69 ecovery of macromolecular structures in cryo-ET data remain challenging as a result of low signal-to-

70 a benchmark by generating large labeled cryo-ET dataset and evaluating existing image processing meth

71 ructures' (TYGRESS) that is a hybrid of cryo-ET and SP-cryo-EM, and is able to achieve close-to-nanom

72 However, the application of cryo-ET is limited to samples that are thinner than most cell

73 enetic or pharmacological perturbation, cryo-ET will allow us to answer previously unimaginable quest

74 imulated results are closer to the real Cryo-ET, making the analysis more difficult.

75 ndow into the cells for high-resolution cryo-ET and structure determination of biomolecules in their

76 Since the content of the simulated cryo-ET is more complex and crowded compared with previous on

77 e, we recorded cryo-electron tomograms (cryo-ET) in which individual cadherins can be discerned; they

78 alculated from cryo-electron tomograms (cryo-ET) of crowded cellular environments is often limited ow

79 -2 virus using cryoelectron tomography (cryo-ET) and subtomogram averaging (STA).

80 Cryo-electron tomography (cryo-ET) can give unprecedented insight into these complexes

81 ning (NS) and cryo-electron tomography (cryo-ET) experimental data.

82 , achieved by cryo-electron tomography (cryo-ET) of re-vitrified cell sections prepared using the Tok

83 Cryo-electron tomography (cryo-ET) provides 3D visualization of subcellular components

84 opy (cryo-EM), cryoelectron tomography (cryo-ET), and scanning electron microscopy (SEM).

85 termined using cryoelectron tomography (cryo-ET).

86 Using cryo-ET, we reveal that Td chemoreceptor arrays assume an unu

87 TP:phosphoethanolamine cytidylyltransferase (ET), encoded by PCYT2, is the rate-limiting enzyme for p

88 distinguish dysmetria from tremor in non-DBS ET.

89 rgoing thalamic deep brain stimulation (DBS; ET(DBS) ) to 19 healthy controls (HC).

90 mOGOR interaction in a manner that decreases ET efficiency compared to the enzyme with no cosubstrate

91 s in net charge upon single ET (e.g., DeltaZ(ET(SOD1)) =0.05+/-0.08 per electron, compared to DeltaZ(

92 0.05+/-0.08 per electron, compared to DeltaZ(ET(Cyt-c)) =1.19+/-0.02).

93 The results demonstrate ET over mesoscopic to microscopic (~100 mum) distances t

94 for total ETs, but also separately for each ET identified by HPLC-MS.

95 Here, we used electrothermal (ET) stirring as a means of controlling the location of a

96 investigated the transfer of ellagitannins (ETs) from selected berry fruits of the Rosaceae family t

97 y induced conformational changes that enable ET from a cluster iron generate dominant additional forc

98 The low amount of endogenous ET that they did produce was sufficient to enable ripeni

99 While endothelin (ET)-1 plays a role in regulating blood flow and pressure

100 acid (SA), jasmonic acid (JA) and ethylene (ET) pathways.

101 concentrations of carotenoids and ethylene (ET) were synthesized.

102 c acid (SA) and jasmonic acid (JA)/ethylene (ET) signalling resulting in trade-offs between defence a

103 ntrolled amount of an 3-ethylesterthiophene (ET) unit.

104 ompletely, even when supplied with exogenous ET.

105 this limit and show long-range extracellular ET over several micrometers.

106 shows strong homology to extratelencephalic (ET) excitatory neurons that project to subcerebral targe

107 In fact, ET-plus might only represent a state condition (ie, pati

108 the higher-E degrees electron transfer FAD (ET-FAD).

109 peats of >60 units were detected in familial ET cases and controls, although 4 ET patients carried 47

110 iodic MOFs affording very efficient and fast ET to mimic natural photosynthetic systems.

111 The fast ET and PT chemistry is attributed to the delocalized ele

112 Compared to TN fetuses, ET fetuses had increased (P = 0.041) placental weights a

113 First, ET(DBS) and ET exhibited greater dysmetria than HC and d

114 posed controls, nicotine increased NGF, FN1, ET-1, COL1A1, and COL3A1 expression in human and mouse L

115 te of mitochondrial ATP production following ET-1 treatment.

116 The kinetics for ET from ITO to Ru(III)P or TPA(+) were quantified spectr

117 .1 mm, 7.0 mm, and 5.0 mm, respectively, for ET, TC, and WT and mean Sorensen-Dice scores of 0.80, 0.

118 s of 0.80, 0.83, and 0.91, respectively, for ET, TC, and WT.

119 s of 0.80, 0.84, and 0.91, respectively, for ET, TC, and WT.

120 ical analysis revealed enhanced staining for ET-1 receptors in the placental labyrinthine zone in hyp

121 These were for ET from radical anions of polydecylthiophene (P3DT) to a

122 Fetuses from ET pigs had reduced (P = 0.032) M. longissimus fibre num

123 of 2 increase results from a transition from ET to one of two acceptors at room temperature to ET to

124 usly undocumented and potentially functional ET nucleotide clusters in the ribosome.

125 lly more stable and incapable of FMN-to-heme ET.

126 If ET-plus had been defined on the basis of a difference in

127 1 day after ablation and tremor improvement (ET: R = -0.52 [P = .03]; PD: R = -0.61 [P = .003]).

128 A-seq analysis was used to assess changes in ET-1 mediated gene expression in primary RGCs, which rev

129 o 3740 Da resulted in a fivefold decrease in ET transfer for raspberry juice, a twofold decrease for

130 the pathological changes that take place in ET.

131 Better tremor relief in ET was associated with lower fractional anisotropy befor

132 w that the metal redox center has no role in ET and that ET is mediated solely by the conjugated back

133 uantify dysmetria independently of tremor in ET.

134 r ratio of the ET unit) with an incorporated ET unit in the ternary copolymers show up-shifted LUMO e

135 functions of the two receptors by inhibiting ET(A)R with macitentan, an ET(A)R antagonist approved fo

136 or the mechanism(s) and timescale of initial ET that are required to achieve a near-quantitative yiel

137 e binding to one BchNB active site initiates ET from the pre-reduced [4Fe-4S] cluster of BchNB, a pro

138 the reorganizational energy of interprotein ET, which suggests design strategies for engineering imp

139 We estimate that the interprotein ET across 6 angstrom between hemes in adjacent proteins

140 By comparison, related intramolecular ET rate constants in very similar constructs were report

141 mary RGCs and in vivo following intravitreal ET-1 injection in rats.

142 and the induction of marker genes of the JA, ET and SA signalling pathways in Arabidopsis thaliana.

143 by AN mediates the coordination of SA and JA/ET pathways to optimise defences against (hemi)biotrophi

144 transcription of genes involved in SA and JA/ET pathways was antagonistically regulated by AN.

145 sion on WRKY33, a master regulator of the JA/ET signalling pathway.

146 ized with TPA and RuP, subnanosecond lateral ET yielded ITO(e(-))|TPA(+).

147 ressable microscale heaters for active local ET stirring.

148 nnest/thickest sectors (R1) and between mean ET and BLT of the inferior temporal quadrant/superior na

149 Main outcome measurements were mean ET and BLT of 25 sectors; the thinnest (minET, minBLT) a

150 ystal lattice, may strongly impact mesoscale ET mainly by increasing the reorganizational energy of i

151 that appear to be nearly ideal for multistep ET.

152 the fundamental mechanism of nonequilibrium ET dynamics, which is critical to uncovering the molecul

153 efined as tremor with the characteristics of ET, with additional neurological signs of uncertain clin

154 a ET-1 and Ang II and elevated expression of ET-1 mRNA in cardiac tissue were detected in Group OSAHS

155 The expression of ET-1 mRNA in heart tissue was detected by RT-PCR.

156 Additionally, this generalization of ET shows that evolutionary constraints among sequence, s

157 OSAHS-induced elevated levels of ET-1 and Ang II may be attributed to myocardial structur

158 was negatively correlated with the levels of ET-1 and Ang II.

159 Lastly, high levels of ET-1 in the SVZ of patients with Cathepsin A-related art

160 The levels of ET-1(endothelin-1) and Ang II (Angiotensin II) in the pl

161 Loss of ET-1 signaling increases neurogenesis and reduces oligod

162 s on new insights regarding the mechanism of ET reactions during catalysis and how they are coupled t

163 ing our understanding of the pathogenesis of ET; however, until recently, the number of such studies

164 days of treatment, a high dose (60 pmol) of ET-1 (E60) alone caused the greatest increase in neuroin

165 ile many studies have shown that the rate of ET is sensitive to the distance between the electron don

166 While the rates of ET over 1-2 nm in proteins can largely be described by s

167 in health, little is known about the role of ET-1 in the cardiovascular response to exercise in hyper

168 the results of recent postmortem studies of ET and attempt to place these findings into an anatomica

169 at VENs are a regionally distinctive type of ET neuron.

170 ortant implications for the understanding of ET and other cerebellar and tremor disorders.

171 The 90% yield of ET to H(B) derives from (minimally) 3 P* populations wit

172 The content of oligomeric ETs in juices was five times lower than that of low mole

173 otential to provide essential information on ET prior to new surgical treatments, such as balloon dil

174 In particular, ET were enriched in polyfunctional T cells.

175 Higher levels of plasma ET-1 and Ang II and elevated expression of ET-1 mRNA in

176 or coined a new term: essential tremor-plus (ET-plus).

177 r, the cerebral damage induced by the 6 pmol ET-1 (E6), Abeta and E6 + Abeta rats was not detrimental

178 thesize a series of polymer acceptors, PTPBT-ET(x) , by polymerizing a small-molecule acceptor unit m

179 r solar cell (all-PSC) based on PBDB-T:PTPBT-ET(0.3) achieved a high power conversion efficiency over

180 In addition, the PTPBT-ET(0.3) -based all-PSC also exhibits long-term photostab

181 nly Y6-like units and thiophene units, PTPBT-ET(x) (where x represents the molar ratio of the ET unit

182 Carriers presenting with a pure ET phenotype may or may not convert to NIID up to 4 deca

183 ter also shows strong homology to a putative ET cluster in human temporal cortex, but with a striking

184 that are indirectly excited by homo-FRET (r(ET)) do not compromise the accuracy of calculated stoich

185 lar cofactors can facilitate such long-range ET.

186 In many cases, PT is coupled to long-range ET.

187 whether the assumptions based on short-range ET hold for sequential ET over mesoscopic distances.

188 be directly used for LLHR, expanding the Rec/ET direct cloning toolbox and providing the possibility

189 mprised of the endothelin A and B receptors (ET(A)R and ET(B)R).

190 726 nm band based on a CT complex of reduced ET-FAD and oxidized Bf-FAD.

191 The reduced ET production by RIN-deficient tomatoes was due to an in

192 the presence and absence of protons reveals ET kinetics and diffusion behavior similar to other smal

193 RIN, ET and other factors are required for completion of the

194 RNA ET is currently available as part of the ET command-line

195 cise training program following RYGB (RYGB + ET) or standard of care (RYGB).

196 ning (e.g., collagen I: RYGB -41% vs. RYGB + ET -76%; P <= 0.0001).

197 e (e.g., Matsuda index: RYGB 123% vs. RYGB + ET 325%; P <= 0.0001).

198 based on short-range ET hold for sequential ET over mesoscopic distances.

199 We further discuss several ET mechanisms, accounting to our observations with possi

200 in, such that ET(A)R activation and silenced ET(B)R expression result in increased carcinogenesis and

201 to resist changes in net charge upon single ET (e.g., DeltaZ(ET(SOD1)) =0.05+/-0.08 per electron, co

202 dynamics simulations illustrate that smaller ET donor-acceptor distances are sampled by the PCET syst

203 In healthy eyes, smooth ET maps were observed.

204 OTCH2NLC GGC repeat expansions in 4 sporadic ET patients.

205 t expansions can be associated with sporadic ET.

206 an increased number of SVZ OPCs, suggesting ET-1's role as a regulator of glial progenitor prolifera

207 Overall, T and T/ET patterns are plausible and qualitatively consistent a

208 89 and .94), but a spread in magnitudes of T/ET (evapotranspiration) from 45% to 77%.

209 ioning methods show expected tendencies of T/ET increasing with dryness (vapor pressure deficit and d

210 Spatial variability of T/ET was primarily driven by vegetation and soil character

211 r at least two continuous years shows that T/ET variability was 1.6 times higher across sites than ac

212 with tremor-free trajectories to the target, ET exhibited greater dysmetria than HC (p < 0.01).

213 adaptive responses to elevated temperature (ET), however, remains largely unknown.

214 In the case of all fruits tested, ET transfer to purees was two to six times greater as co

215 etal redox center has no role in ET and that ET is mediated solely by the conjugated backbone of the

216 Our results demonstrate that ET-1 produced a decrease in expression of vital componen

217 Furthermore, the finding that ET-1 constrains the blood flow response to exercise sugg

218 se findings in patients, we hypothesize that ET(A)R and ET(B)R play dichotomous roles in oral carcino

219 These data indicate that ET(A) receptor antagonism could be a viable therapeutic

220 We also show that ET-1 is required for increased neural stem cell and OPC

221 s in oral carcinogenesis and pain, such that ET(A)R activation and silenced ET(B)R expression result

222 lood flow response to exercise suggests that ET(A) receptor antagonism could be a therapeutic approac

223 The ET lumen diameter was significantly lower according to e

224 The ET rate is found to be not very sensitive to the degree

225 with microsecond molecular dynamics, and the ET and PCET rate constants are calculated with the corre

226 on of a protein conformation that brings the ET-flavin and Bf-flavin into direct contact, explaining

227 itiation and this could be suppressed by the ET perception inhibitor 1-MCP.

228 We therefore explored the ET distance dependence for the CPET oxidation of tyrosin

229 ulmonary hypertension, and re-expressing the ET(B)R gene with adenovirus transduction, and determine

230 importance of conformational dynamics in the ET process.

231 lex ((Au)MQ-ADN) assists HAT by limiting the ET channel, on the other hand, FeNP on the MQ-ADN comple

232 3T MRI provides an evaluation of the ET cartilage and isthmus level, which are small but impo

233 Visualisation of the ET cartilage was assessed on the MR images using a three

234 In the patient group, the diameter of the ET cartilage was significantly smaller than in the contr

235 der, and the medial laminal thickness of the ET cartilage.

236 RNA ET is currently available as part of the ET command-line package, and will be available as a web-

237 ap, the R1ET, and the thinnest sector of the ET map.

238 ) (where x represents the molar ratio of the ET unit) with an incorporated ET unit in the ternary cop

239 dependence of the PCET rate constant on the ET donor-acceptor distance is explained in terms of an a

240 In the axial plane, the ET lumen's diameter was measured from the mid-portion of

241 Thus, ET-1, acting through the ET(A) receptors, contributes to the control of blood pre

242 ow energy from ATP hydrolysis transduces the ET processes.

243 l populations recommend an exercise therapy (ET) prescription of fixed intensity (moderate), duration

244 We find that the efficiency of this ET depends strongly on whether the succinyl CoA (SCoA) c

245 Essential thrombocythemia (ET) is characterized by abnormal megakaryopoiesis and en

246 dic and familial essential thrombocythemias (ETs).

247 icals of MQ and ADN, photo-generated through ET and HAT.

248 Thus, ET-1, acting through the ET(A) receptors, contributes to

249 tly interfered with short-term adaptation to ET by blocking leaf hyponasty and evaporative cooling.

250 one of two acceptors at room temperature to ET to a superposition state of the two acceptors with co

251 ing the tilt series of electron tomographic (ET) images of a targeted particle through a focused iter

252 yo-EM data generated by electron tomography (ET) contains images for individual protein particles in

253 ctron microscopy and 3D electron tomography (ET) of the egress zones revealed clusters of virions wit

254 ployed for many years in electronic tongues (ETs), with unique properties of bio-inspired materials,

255 stribution was calculated not only for total ETs, but also separately for each ET identified by HPLC-

256 follows the phylogenetic Evolutionary Trace (ET) paradigm, first developed and extensively validated

257 tions in the photoinduced electron transfer (ET) and hydrogen atom transfer (HAT) pathways between an

258 re found in several other electron transfer (ET) complexes, but how this architecture influences acti

259 etic effect of increasing electron transfer (ET) distance in a biomimetic, proton-coupled electron-tr

260 ne (SAM) enzymes involves electron transfer (ET) from [4Fe-4S](+) to SAM, generating an R(3)S(0) radi

261 date the critical role of electron transfer (ET) from CdS NRs to MmOGOR.

262 nitrogenase orchestrates electron transfer (ET) from the Fe-protein to the catalytic site of MoFe-pr

263 We report 90% yield of electron transfer (ET) from the singlet excited state P* of the primary ele

264 constants for bimolecular electron transfer (ET) increased with driving force, -DeltaG degrees , reac

265 Rapid and directed electron transfer (ET) is essential for biological processes.

266 ur calculations show that electron transfer (ET) occurs in the normal Marcus regime on a sub-nanoseco

267 ) sites reflecting facile electron transfer (ET) pathways, which may be protective against uncoupled

268 ton transfer (PT) and two electron transfer (ET) processes.

269 A variety of electron transfer (ET) reactions in biological systems occurs at short dist

270 compared to the analogous electron transfer (ET) systems.

271 tal biological process of electron transfer (ET) takes place across proteins with common ET pathways

272 ulate net charge (Z) upon electron transfer (ET) was recently measured for the first time using "prot

273 facile PT concerted with electron transfer (ET), known as the Volmer mechanism.

274 nment of a highly efficient energy transfer (ET).

275 , lambda, for interfacial electron transfer, ET, from a conductive electrode to redox-active molecule

276 in and trans FMN-to-heme electron transfers (ETs).

277 ean age 9.4 y), classified as early treated (ET; age at ART initiation <=0.5 y, n = 14) or late treat

278 develop resistance to endocrine treatments (ET) and relapse with metastatic disease.

279 Essential tremor (ET) is the most common tremor disorder globally and is c

280 Methods Participants with essential tremor (ET) or Parkinson disease (PD) undergoing thalamotomy wer

281 62 subjects comprising 462 essential tremor (ET) subjects (285 sporadic, 125 with family history, and

282 In addition to redefining essential tremor (ET), the 2018 consensus statement of the Movement Disord

283 rkinson's disease (PD) and Essential Tremor (ET).

284 rkinson's Disease (PD) and Essential Tremor (ET).

285 of ataxia, from tremor in essential tremor (ET).

286 to prospectively assess the Eustachian tube (ET) cartilage using 3 Tesla (3T) magnetic resonance imag

287 evaluated in three classes: enhancing tumor (ET), tumor core (TC), and WT.

288 Here, we show that these ultrafast ET dynamics highly depend on the coupling between enviro

289 The possibility of a unique ET distance dependence for CPET reactions deserves furth

290 ombic perturbations to residue pK(a) 's upon ET at copper, allowing SOD1's "electrostatic loop" to at

291 Description of the data using ET theory identifies smaller electronic couplings for th

292 k noted that a CT band at 726 nm formed when ET-FAD was reduced and Bf-FAD was oxidized, suggesting t

293 oenergetics and suggest a mechanism by which ET-1 promotes neurodegeneration of RGCs in glaucoma.

294 o modulate important factors associated with ET in a facile manner, such as the type of the cofactor

295 mune activation pathways in LT compared with ET.

296 , we compared 19 participants diagnosed with ET undergoing thalamic deep brain stimulation (DBS; ET(D

297 lls and climbing fibres, in individuals with ET.

298 Results Twenty-two study participants with ET (mean age, 72 years +/- 6 [standard deviation]; 14 me

299 nd a replication set of 17 participants with ET (mean age, 73 years +/- 6; 10 men) were evaluated.

300 present a state condition (ie, patients with ET might develop these additional clinical features when

301 vation in the vast majority of patients with ET.