ライフサイエンスコーパス: FFPE

1 We also analyzed a further 118 FFPE samples.

2 A typical 30-antibody dataset for 20 FFPE slides can be generated within 2 weeks.

3 We confirmed accuracy using 249 FFPE cancer specimens characterized by established assay

4 with GBM, total RNAs were isolated from 268 FFPE tumor samples, miR expression was assayed (simultan

5 Series 3 included 270 FFPE samples from patients recruited in Haifa, Northern

6 For example, TMA analysis of 300 FFPE cores would typically require 6 h of total time thr

7 ions, whole-genome CNVseq was applied to 300 FFPE primary tumour samples, obtained from a large-scale

8 The method was evaluated on a cohort of 31 FFPE tissue samples, pursuing a statistical validation a

9 using transcriptomes of TCGA cohort and 3116 FFPE samples.

10 tion of a gene rearrangement panel using 319 FFPE samples showed 100% sensitivity (95% confidence lim

11 nine different areas microdissected from 32 FFPE UMs.

12 ormed ribo-deplete RNA extractions on > 3200 FFPE slide samples; 25 of these had direct FFPE vs. fres

13 n tissue-derived prognostic signatures in 42 FFPE CRC samples measured by both platforms.

14 ations in small populations of RKO and MCF-7 FFPE cell blocks.

15 ) could extract fungal DNA from 69 of the 74 FFPE tissues from which a housekeeping gene could be amp

16 A total of 779 FFPE samples from patients with metastatic colorectal ca

17 Tissue samples from 78 FFPE specimens with both histopathology and correspondin

18 n 3 cohorts, including 18 snap-frozen and 83 FFPE tissues.

19 140 samples, 47 fresh frozen samples and 93 FFPE samples, on HU133_Plus_2.0 and HuEx_1.0_st arrays,

20 essfully characterized and visualized from a FFPE mouse brain section.

21 ribution patterns could be identified from a FFPE mouse ovarian cancer tissue section.

22 integrate data for combined analyses across FFPE/FF and platforms using established batch correction

23 Liver allograft FFPE C4d staining: (a) can help classify liver allograft

24 oducible microdissection of nuclei across an FFPE rat brain tissue section in milliseconds.

25 The ability to retrospectively analyze FFPE tissues for DNA adducts may provide clues to the or

26 plicons both in snap-frozen (P = 0.0006) and FFPE (P = 0.0152) tissues.

27 d in comparable yields from fresh-frozen and FFPE preserved tissues of rodents treated with the proca

28 NanoCRCA classified fresh frozen and FFPE samples into all five CRCA subtypes with consistent

29 y retrospective studies of paired frozen and FFPE samples, which identified consistent enrichment in

30 quencing profiles between matched frozen and FFPE samples.

31 all RNA profiling on matched snap-frozen and FFPE specimens exposed to different delays to fixation,

32 was found to differ between snap-frozen and FFPE specimens in a consistent manner across tissue grou

33 te, malic acid, and glutamate) in frozen and FFPE tissues specimens.

34 ingle short amplicon between snap-frozen and FFPE tissues was only 36%.

35 2HG enantiomers (D- and L-2HG) in frozen and FFPE tissues.

36 A from cell lines, fresh frozen material and FFPE samples to assess copy number variation.

37 h known CN, including tonsil, placentae, and FFPE melanoma cell lines.

38 t for each platform, gene or transcript, and FFPE processing regime.

39 and risk group in 108 (98%) of 110 archival FFPE biopsies.

40 RNA was extracted from archival FFPE renal biopsies of 52 IgAN patients, 22 non-IgAN and

41 ut high-quality DNA extraction from archival FFPE tissue specimens remains complex and time-consuming

42 aCGH application to a set of archival FFPE samples of skin squamous cell carcinomas detected a

43 aid a foundation for the utility of archival FFPE specimens for oncometabolite profiling as a valid t

44 nhancer (SE) annotation in numerous archived FFPE samples from distinct tumor types.

45 teomics using very small amounts of archived FFPE tissue.

46 Eighty-one archived FFPE tissues with a positive Gomori methenamine silver (

47 We further demonstrated that archived FFPE clinical specimens can be CLARITY-processed, immuno

48 and X (13|X PRT) were tested using archived FFPE pathology samples with known CN, including tonsil,

49 nical diagnosis and prognosis using archived FFPE tissue.

50 ce most pathologic specimens are archived as FFPE samples, the ability to use them to generate expres

51 atively compared to conventional slide-based FFPE histology.

52 Because FFPE is a routine diagnostic sample preparation, the fea

53 expression significantly correlated between FFPE and RNAlater samples.

54 that resulted in strong correlations between FFPE and frozen biospecimens may provide guidance when o

55 Blinded FFPE specimens from cases (specimens positive on histopa

56 mbedded (FFPE) samples and validated in both FFPE and frozen tissues.

57 tively using QDB method in 332 breast cancer FFPE samples.

58 perience with performing AMP on 986 clinical FFPE samples, we show its potential as both a robust cli

59 ostate cancer patients and a set of clinical FFPE samples.

60 ured in tissue microarrays (TMAs) containing FFPE samples from two independent lung cancer cohorts (n

61 s of LISH-based assays using patient-derived FFPE tissue.

62 nes were evaluated for the ability to detect FFPE infected cells.

63 undertaken on routinely collected diagnostic FFPE tissue into stratification schemes for medulloblast

64 0 FFPE slide samples; 25 of these had direct FFPE vs. fresh frozen (FF) replicates, 57 were sequenced

65 ome coverage was highly concordant in direct FFPE and FF replicates, with 98% agreement in coding exo

66 CI 0.31-1, P = 0.042, respectively, for each FFPE dataset).

67 RNA-seq of formalin-fixed paraffin embedded (FFPE) and fresh frozen (FF) sequential patient-matched b

68 imens are formalin-fixed, paraffin embedded (FFPE) archival samples, making this type of tissue a pot

69 6-63.7 nm (formalin fixed paraffin embedded (FFPE) dewaxed) and 63.4 (formalin fixed), being 0.9 nm s

70 files from formalin-fixed paraffin embedded (FFPE) material, the only likely readily available biospe

71 markers in Formalin Fixed Paraffin Embedded (FFPE) samples promises improved objectivity, consistency

72 profiling, formalin fixed paraffin embedded (FFPE) samples represent an interesting source for retros

73 igation of formalin fixed paraffin embedded (FFPE) tissue samples and shows a high potential for appl

74 Formalin-fixed, paraffin embedded (FFPE) tissue samples provide an invaluable resource for

75 (CN) using formalin fixed paraffin embedded (FFPE) tissue.

76 contrast, formalin-fixed paraffin embedded (FFPE) tissues frequently are accessible for biomarker di

77 ively from formalin fixed paraffin embedded (FFPE) tissues, signifying FFPE tissues can serve as bios

78 markers in formalin fixed paraffin embedded (FFPE) tissues.

79 ections of formalin fixed paraffin embedded (FFPE) tumor tissues.

80 Formalin-fixed paraffin-embedded (FFPE) archival material, the analysis of which is import

81 available formalin-fixed paraffin-embedded (FFPE) biopsies.

82 PD-L1 on formalin-fixed, paraffin-embedded (FFPE) biopsy specimens from 48 cervical SCCs and 23 vulv

83 including formalin-fixed paraffin-embedded (FFPE) blocks.

84 nes using formalin-fixed, paraffin-embedded (FFPE) cancer tissues is becoming the standard for identi

85 nalysis of formalin-fixed paraffin-embedded (FFPE) cell block and tissue sections.

86 outine formalin-fixed and paraffin-embedded (FFPE) clinical specimens.

87 ofiles of formalin-fixed, paraffin-embedded (FFPE) clinical trial samples.

88 Formalin-fixed paraffin-embedded (FFPE) colon cancer tissues were collected from 53 stage

89 l archival formalin-fixed paraffin-embedded (FFPE) congenital cutaneous and hepatic hemangiomas, 4/8

90 -treatment formalin-fixed paraffin-embedded (FFPE) duodenum biopsies used for clinical diagnosis.

91 is study, formalin-fixed, paraffin-embedded (FFPE) gastric biopsy specimens from a cohort of individu

92 archival formalin-fixed, paraffin-embedded (FFPE) human MPNST with and without PRC2 loss (MPNST(LOSS

93 es and formalin-fixed and paraffin-embedded (FFPE) human tumors, as well as their functional role in

94 or are formalin-fixed and paraffin-embedded (FFPE) in order to maintain tissue morphology for histolo

95 en and 23 formalin-fixed, paraffin-embedded (FFPE) MTCs was used for validation by RT-qPCR.

96 d CD40 in formalin-fixed, paraffin-embedded (FFPE) NSCLC specimens.

97 g from formalin-fixed and paraffin-embedded (FFPE) primary tumor specimens.

98 n = 47) or formalin-fixed paraffin-embedded (FFPE) samples (n = 58).

99 veloped in formalin-fixed paraffin-embedded (FFPE) samples and validated in both FFPE and frozen tiss

100 d from formalin-fixed and paraffin-embedded (FFPE) samples of 121 human gastrointestinal stromal tumo

101 nalysis of formalin-fixed paraffin-embedded (FFPE) samples, which largely precludes the analysis of m

102 eserved as formalin-fixed paraffin-embedded (FFPE) samples.

103 or use on formalin-fixed, paraffin-embedded (FFPE) samples.

104 regions of formalin-fixed paraffin-embedded (FFPE) sections underwent macrodissection, DNA extraction

105 cies from formalin-fixed, paraffin-embedded (FFPE) skin biopsy specimens.

106 archived formalin-fixed, paraffin-embedded (FFPE) specimens contain valuable molecular insight into

107 s fungi in formalin-fixed paraffin-embedded (FFPE) specimens obtained from combat casualties injured

108 eserved as formalin-fixed paraffin-embedded (FFPE) specimens stored in tissue banks.

109 roducts in formalin-fixed paraffin-embedded (FFPE) specimens would be of great utility.

110 input from formalin-fixed paraffin-embedded (FFPE) specimens.

111 Formalin-fixed and paraffin-embedded (FFPE) tissue biospecimens are a valuable resource for mo

112 Archived formalin-fixed paraffin-embedded (FFPE) tissue collections represent a valuable informatio

113 ession and formalin-fixed paraffin-embedded (FFPE) tissue datasets.

114 Using formalin-fixed paraffin-embedded (FFPE) tissue for immunohistochemistry, fluorescent in si

115 ns such as formalin-fixed paraffin-embedded (FFPE) tissue for molecular mechanisms of disease progres

116 ulatum in formalin-fixed, paraffin-embedded (FFPE) tissue is described.

117 available formalin-fixed paraffin-embedded (FFPE) tissue is often too degraded for quality sequencin

118 A from formalin-fixed and paraffin-embedded (FFPE) tissue remains a challenge, despite numerous attem

119 matin from formalin-fixed paraffin-embedded (FFPE) tissue samples for accurate detection of histone m

120 nalysis of formalin-fixed paraffin-embedded (FFPE) tissue samples.

121 n archival formalin-fixed paraffin-embedded (FFPE) tissue samples.

122 processed formalin-fixed, paraffin-embedded (FFPE) tissue section soaked in a polyethylene glycol sol

123 icable to formalin-fixed, paraffin-embedded (FFPE) tissue sections have been described, the majority

124 ycans from formalin-fixed paraffin-embedded (FFPE) tissue sections.

125 tion from formalin-fixed, paraffin-embedded (FFPE) tissue sections.

126 frozen and formalin-fixed paraffin-embedded (FFPE) tissue sections.

127 vered from formalin-fixed paraffin-embedded (FFPE) tissue slides are suitable for scDNase-seq assays.

128 tings, formalin-fixed and paraffin-embedded (FFPE) tissue specimens are collected routinely and there

129 nalysis of formalin-fixed paraffin-embedded (FFPE) tissue using bladder cancer as an exemplar; and (2

130 d, such as formalin-fixed paraffin-embedded (FFPE) tissue, remain challenging to study with nonspecia

131 RNAs)) in formalin-fixed, paraffin-embedded (FFPE) tissues and cultured cells, using locked nucleic a

132 fresh and formalin-fixed, paraffin-embedded (FFPE) tissues and sterile body fluids with known diagnos

133 Formalin-fixed paraffin-embedded (FFPE) tissues are a priceless resource for diagnostic la

134 Formalin-fixed paraffin-embedded (FFPE) tissues are important resources for molecular medi

135 markers in formalin-fixed paraffin-embedded (FFPE) tissues by liquid chromatography-tandem mass spect

136 this onto formalin-fixed paraffin-embedded (FFPE) tissues for MALDI imaging of N-glycans.

137 ction from formalin-fixed paraffin-embedded (FFPE) tissues is difficult and requires special protocol

138 uch as formalin-fixed and paraffin-embedded (FFPE) tissues requires reversal of chemical crosslinking

139 acted from formalin-fixed paraffin-embedded (FFPE) tissues to provide whole-genome transcriptome anal

140 contrast, formalin-fixed paraffin-embedded (FFPE) tissues with clinical diagnosis are readily access

141 acking on formalin-fixed, paraffin-embedded (FFPE) tissues, and particularly for microRNA (miRNA) ana

142 ization in formalin-fixed paraffin-embedded (FFPE) tissues, we developed multicolor miRNA FISH.

143 ohilum in formalin-fixed, paraffin-embedded (FFPE) tissues.

144 yeasts in formalin-fixed paraffin-embedded (FFPE) tissues.

145 moters in formalin-fixed, paraffin-embedded (FFPE) tissues.

146 ubtypes in formalin-fixed paraffin-embedded (FFPE) tissues.

147 ta)-in 56 formalin-fixed, paraffin-embedded (FFPE) TNBCs.

148 archived, formalin-fixed paraffin-embedded (FFPE) tumor samples for massive parallel sequencing has

149 ducible in formalin-fixed paraffin-embedded (FFPE) tumor specimens.

150 ssessed in formalin-fixed paraffin-embedded (FFPE) tumor tissue.

151 n archival formalin-fixed paraffin-embedded (FFPE) tumour biopsy or consented to a new biopsy at scre

152 formed on formalin-fixed, paraffin-embedded (FFPE) whole tumor sections from 19 disomy 3 metastasizin

153 mples are Formalin-Fixed, Paraffin-Embedded (FFPE).

154 n) and 163 formalin-fixed paraffin-embedded (FFPE, median age 67, 39% women) samples, respectively.

155 ia formalin fixation and paraffin embedding (FFPE).

156 or formalin-fixation and paraffin-embedding (FFPE) and RNAlater preservation (RNAlater).

157 by formalin-fixation and paraffin-embedding (FFPE).

158 Compared to FF, FFPE transcripts coding for nuclear/cytoplasmic proteins

159 ewly developed and validated MCL35 assay for FFPE biopsies uses the proliferation signature to define

160 isolated from normal tissue and 368-fold for FFPE tumors.

161 d a reliable rapid DNA extraction method for FFPE tissue specimens.

162 w normalization method, labeled MIXnorm, for FFPE RNA-seq data.

163 ch include: the designing of PCR primers for FFPE tumor tissue samples versus normal blood samples, d

164 igh-throughput gene expression profiling for FFPE samples.

165 ance when optimizing molecular protocols for FFPE use; however, discrepancies reported for similar as

166 renal transplant biopsy procedure split for FFPE and RNAlater, 21% of 219 genes of potential biologi

167 We demonstrate that FiT-seq data from FFPE specimens are concordant with ChIP-seq data from fr

168 equencing capped 5' ends of RNA derived from FFPE samples.

169 uantitative measurements of RNA derived from FFPE specimens is challenging because of low yields and

170 fungal assay identifies fungi directly from FFPE tissues and can be a useful adjunct to traditional

171 -PCR analysis of p15, RNA was extracted from FFPE sections from 14 nevus and melanoma samples via mac

172 iochemical analysis, protein extraction from FFPE tissue was optimized.

173 was developed for analysis of N-glycans from FFPE treated tissue sections.

174 aid in the diagnosis of histoplasmosis from FFPE tissue.

175 thod to quantitatively retrieve dA-AL-I from FFPE tissue.

176 ddition, sequence variations identified from FFPE RNA show 99.67% concordance with that from exome se

177 on individual cell populations isolated from FFPE tissue sections using laser capture microdissection

178 ity RNA samples, such as those isolated from FFPE tissue, remains a challenge.

179 by laser-capture microdissection (LCM) from FFPE tissue.

180 g high-quality 5' end RNA-seq libraries from FFPE-derived RNA.

181 enomic and expression profiles obtained from FFPE biospecimens accurately reflect the physiologic con

182 ntly high quality RNA could be obtained from FFPE tumor tissues to detect frozen tissue-derived progn

183 ocols for DNA extraction and processing from FFPE tissues utilizing DNase processing to generate rand

184 analysis to generate proteomic profiles from FFPE samples of intestinal-type gastric cancer, metaplas

185 lso obtain distinct biological profiles from FFPE single cells, which have been impossible to study w

186 Capture transcriptome profiling from FFPE revealed two oncogenic fusions: the pathognomonic N

187 The entire protocol from FFPE blocks to sequence-ready library can be accomplishe

188 ldwide, can be recovered quantitatively from FFPE tissues.

189 the technology of DNA adduct retrieval from FFPE tissue clear the way for use of archived pathology

190 specific at discriminating each species from FFPE controls of unrelated bacterial, viral, protozoan,

191 ssification of selected matched fresh frozen/FFPE samples.

192 ons of islet hormones were observed in human FFPE tissues preserved for more than five years, demonst

193 oString technology, RNA from 40 stage II-III FFPE primary melanomas was analyzed and a 53-immune-gene

194 However, MSI is not effective for imaging FFPE tissues because of the chemical modifications of an

195 and homogenization, the protein analytes in FFPE tumor tissues were spiked with a known concentratio

196 reater sensitivity than nested PCR assays in FFPE tissues and provides an effective method to specifi

197 solute quantitation of protein biomarkers in FFPE samples to meet the need of daily clinical practice

198 quantify low abundant protein biomarkers in FFPE tissues with improved sensitivity, specificity, and

199 y to quantify clinical protein biomarkers in FFPE tumor sections using automated antipeptide antibody

200 This successful analysis of CN in FFPE material using NGS provides proof of principle for

201 efore, PRTs are suitable for analyzing CN in FFPE tissues.

202 High expression of CXCL1 in FFPE samples from explant cultures of CRC patients-deriv

203 antigens, and PCR identified Exserohilum in FFPE and fresh tissues.

204 lar detection and identification of fungi in FFPE tissue.

205 sensitive method for detection of fungus in FFPE tissues, demonstrating both hyphal forms and granul

206 alence and characteristics of HPV genomes in FFPE tissue from the cervices of 99 women undergoing hys

207 GenomePlex kit) in FFPE normal and tumor tissue specimens.

208 faithfully capture mRNA expression levels in FFPE specimens while also detecting enhancer RNAs that a

209 aristolochic acids (AAs) can be measured in FFPE tissues at a level of sensitivity comparable to fre

210 studies have tested different WGA methods in FFPE cancer specimens using targeted next-generation seq

211 it may not detect certain abundant miRNAs in FFPE tissue.

212 zation of differentially expressed miRNAs in FFPE tumor tissues.

213 In an effort to detect various mutations in FFPE tissue samples among multiple solid tumor types for

214 tion of altered levels of oncometabolites in FFPE specimens.

215 PA can detect monosomy 3 cell populations in FFPE whole tumor sections previously missed by FISH perf

216 rotocol (FiT-seq) for chromatin profiling in FFPE.

217 describe a protocol for analyzing protein in FFPE-TMAs using matrix-assisted laser desorption/ionizat

218 he possibility of long RNA quantification in FFPE tissues, we selected 14 target RNAs (8 mRNAs and 6

219 er, long-chain RNA analysis is restricted in FFPE tissues due to high levels of degradation.

220 apping short amplicons for 14 target RNAs in FFPE tissues.

221 ell subtypes, but this has not been shown in FFPE melanomas.

222 ozen tissue-derived prognostic signatures in FFPE CRC samples, we evaluated the expression of 516 gen

223 novel MSI method to image protein targets in FFPE tissue samples.

224 mas using a new RNA expression technology in FFPE tissue would correlate with the same immune cells i

225 n with prognosis was tested in 2 independent FFPE datasets.

226 xpression that was not evident in individual FFPE sections (2D).

227 enes did not correlate across the 51 matched FFPE and RNAlater samples.

228 high correlation between frozen and matched FFPE samples (R(2) between 0.82 and 0.89), while the sig

229 er tumors archived for >11 years as 5 microm FFPE sections and matched germline DNA.

230 ) and ITS4 primers yielded a product in most FFPE tissues.

231 Multiple FFPE core biopsies can be assembled in a single block to

232 A 40-mum FFPE tissue section from each specimen was digested with

233 ion data for colon and lung tumor and normal FFPE samples and matched frozen samples and found a high

234 ature genes from tumor versus matched normal FFPE tissue from colon and lung were identified as cance

235 The tumor samples show differing amounts of FFPE damaged DNA sequencing reads revealed as relatively

236 ive proteomic analysis of limited amounts of FFPE material.

237 ming genome-wide deep sequencing analysis of FFPE archived tumors of limited sample size such as resi

238 LISH analysis of FFPE RNA is a novel methodology with broad applications

239 alternative methodology for the analysis of FFPE RNA.

240 r, the implementation in routine analysis of FFPE samples, following legislation demands for validate

241 Next-Generation Sequencing (NGS) analysis of FFPE specimens.

242 l facilitate protein biochemical analysis of FFPE tumor samples and justifies the development of ther

243 The direct analysis of FFPE-TMA tissue using IMS allows direct analysis of mult

244 chniques to examine the molecular content of FFPE tissue, mass spectrometry imaging (MSI) is the most

245 demonstrate spatially resolved genotyping of FFPE sections of human breast invasive ductal carcinoma.

246 al oncometabolites from pooled homogenate of FFPE or frozen tissue ranged 86-112%.

247 nally reduced once the CT value for 10 ng of FFPE DNA increased above 30 cycles, reflecting importanc

248 ntion has been given to the normalization of FFPE RNA-seq data, a key step that adjusts for unwanted

249 ce somatic mutations even in the presence of FFPE induced DNA damage.

250 rays for comparative expression profiling of FFPE biopsies of 18 primary canine OMM that metastasised

251 RK-10 shows staining in the tumor regions of FFPE tissues where the SP263 kit does not.

252 gnostic archives are an enormous resource of FFPE tissue, but extracted DNA is of poor quality and ma

253 Overall, 71 samples of FFPE tissue from cases of cervical SCCs (n = 48) and vul

254 measured in 10-mum thick tissue-sections of FFPE kidney from patients with upper urinary tract cance

255 nd follow this up with data from a series of FFPE biopsies and surgical samples.

256 These results advance our understanding of FFPE samples as a resource for genomic research.

257 Study limitations include the use of FFPE samples, which do not always provide high-quality D

258 provide strong rationale for clinical use of FFPE-derived RNA based on the robustness, reproducibilit

259 To assess the clinical utility of FFPE-derived RNA, we performed ribo-deplete RNA extracti

260 analysis was demonstrated with a variety of FFPE tissue sections.

261 ful to quantify intratumoral immune cells on FFPE specimens through RNA gene expression in metastatic

262 otein expression at the single-cell level on FFPE patient samples.

263 amples, was performed: analyses were made on FFPE tissues sections routinary used for histological in

264 histochemistry for alphaSMA was performed on FFPE sections and subsequently quantified via digital im

265 ue proteomic analyses have been performed on FFPE tissues using advanced mass spectrometry (MS) techn

266 tation of the immunofluorescence workflow on FFPE sections milled at histological thickness, cellular

267 Tumor data analyzed by Affymetrix OncoScan FFPE Assay yielded the log ratio (R) and B-allele freque

268 ed by next-generation sequencing in 51 OpSCC FFPE samples.

269 celiac pathogenesis using clinical pathology FFPE samples, and can stimulate new approaches to addres

270 Single endoscopic pinch FFPE biopsies (n = 41) were sampled at both active and i

271 ng short amplicons in standardized-preserved FFPE tissues.

272 The locked assay was applied to pretreatment FFPE lymph node biopsies from an independent cohort of 1

273 independent validation cohort of 56 primary FFPE TNBC tumors, the Immune Activation Score was signif

274 death-ligand 1 (PD-L1) in 15 representative FFPE tumor samples from lung, colorectal, and head and n

275 bolites were notably lost during the routine FFPE process.

276 enotypes microdissected from within the same FFPE sample.

277 N-linked glycans and proteins from the same FFPE tissue section.

278 Methods Forty-seven FFPE biopsies were used to train an assay on the NanoStr

279 paraffin embedded (FFPE) tissues, signifying FFPE tissues can serve as biospecimens for carcinogen DN

280 es with 87% accuracy relative to H&E-stained FFPE sections.

281 the lack of antibodies suitable for staining FFPE tissue, primarily due to the inaccessibility of the

282 The FFPE process results in fragmentation and chemical modif

283 For the normalized copy number analysis, the FFPE process caused none or very minimal bias.

284 ex was associated with prognosis only in the FFPE dataset from Israel (HR = 2.45, 95% CI 1.39-4.32, P

285 ng of the EMT positive breast cancer tissue (FFPE (dewaxed)) is within the range 64.5-64.7 nm corresp

286 on formalin-fixed paraffin embedded tissue (FFPE) sections using the Oxford classification.

287 in formalin-fixed paraffin-embedded tissues (FFPE) from donor-specific antibody-positive (DSA+) renal

288 -reaching impact, they must be applicable to FFPE material.

289 conversion that should extend, generally, to FFPE and other types of samples intended for any analyti

290 some platforms appear to be better suited to FFPE samples, particularly archival material.

291 total protein lysate extracted from 2 x 5 um FFPE slices absolutely and quantitatively using QDB meth

292 us strains (DMV, PWMV and novel CeMVs) using FFPE samples from 1996 to 2011.

293 w accepted that proteomics can be done using FFPE tissue and can generate similar results as snap-fro

294 Assay validation was performed using FFPE preparations of cell lines with known SOX2 expressi

295 correspondence with disease phenotype, using FFPE diagnostic surgical pathology specimens.

296 esions by generating proteome profiles using FFPE samples.

297 Thus, proteomic profiling using FFPE samples has led to the identification of two novel

298 particular, Smart-3SEQ's compatibility with FFPE tissue unlocks an enormous number of archived clini

299 and confidence in the results obtained with FFPE biospecimens.

300 validating protocols optimized for use with FFPE specimens with a case-matched fresh or frozen cohor