ライフサイエンスコーパス: FGF receptor

1 ion in the paracrine activation of Heartless FGF receptor.

2 ltikinase inhibitor that targets BCR-ABL and FGF receptor.

3 that Cubn is a novel, interspecies-conserved Fgf receptor.

4 inity signaling complexes with their cognate FGF receptor.

5 action between different FGF ligands and the FGF receptor.

6 aling through this pathway downstream of the FGF receptor.

7 dependent expression of the breathless (btl) FGF receptor.

8 sine-kinase inhibitor that inhibits VEGF and FGF receptors.

9 e to their different binding affinities with FGF receptors.

10 ly sensitive to small molecule inhibitors of FGF receptors.

11 ble FGF traps or a dominant inhibitor of all FGF receptors.

12 d ability of FGF23 to signal via its cognate FGF receptors.

13 nductive activity due to higher affinity for Fgf receptors.

14 ished binding of a subset of FGF proteins to FGF receptors.

15 at BMP signaling is required at the level of FGF receptors.

16 Yet, TAMS not T cells express FGF receptors.

17 We created two lines of mice lacking both FGF receptor 1 (Fgfr1) and Fgfr2 in oligodendrocyte-line

18 NgR1 and FGF receptor 1 (FGFR1) are colocalized to synapses, and

19 While loss-of-function mutations in FGF receptor 1 (FGFR1) cause human GnRH deficiency, to d

20 we show using signal transduction mutants of FGF receptor 1 (FGFR1) expressed in rat VSMC that the ad

21 Here we examined FGF receptor 1 (FGFR1) expression and investigated its i

22 FGF receptor 1 (FGFR1) expression is restricted to MMCm

23 mal transition (EndMT) and its key regulator FGF receptor 1 (FGFR1) in atherosclerosis.

24 Morpholino knockdown of FGF receptor 1 (Fgfr1) in zebrafish cell-autonomously re

25 e defect had been identified: a heterozygous FGF receptor 1 (FGFR1) mutation in pedigree 1 and a comp

26 nce suggests that bFGF selectively activates FGF receptor 1 (FGFR1) to exert degradative effects in b

27 ctive factors include FGFs via activation of FGF receptor 1 (FGFR1).

28 nase (ERK)-cFos pathway after binding to the FGF receptor 1 (FGFR1).

29 tified SK1 as a target of the canonical FGF2/FGF receptor 1 activation pathway in endothelial cells a

30 Moreover, a differential expression of Fgf Receptor 1 and 2 resembling that previously found in

31 functions by blocking FGF2 signaling through FGF receptor 1 and syndecan-4 and downstream effectors p

32 r, rPAI-1(23) blocked FGF2 signaling through FGF receptor 1 and syndecan-4, inhibiting cell migration

33 signaling in animal caps, did interact with Fgf receptor 1 in cultured cells and, according to conte

34 c activity and is mediated predominantly via FGF receptor 1 signalling.

35 lt, 12 hits were identified including FGFR1 (FGF receptor 1), TrkB, and TrkC as well as components of

36 sumably mediated by activation of the FGFR1 (FGF receptor 1), which is expressed in mammalian brain m

37 homeostasis and eating/drinking behavior via FGF receptor 1/Klothobeta (FGFR1/KLB) complexes expresse

38 FGF receptors 1 and 2 (Fgfr1 and Fgfr2) are both express

39 llar development are primarily transduced by FGF receptors 1 and 2.

40 FGF receptors 1, 2, and 3 (Fgfrs) are expressed in the e

41 eceptors 1-3, PDGF receptors alpha and beta, FGF receptors 1-3, and Src and Abl kinases, which are al

42 activation of the fibroblast growth factor (FGF) receptor 1 (FGFR1) are a feature of stem cell leuke

43 (BMP) receptor or fibroblast growth factor (FGF) receptor 1, we demonstrate that the BMP and FGF sig

44 or intra-DMS blockade of the FGF2 receptor, FGF receptor-1 (FGFR1), suppresses alcohol consumption,

45 nity heparan sulfate co-receptor and blocked FGF receptor-1 autophosphorylation and p42/44 MAP kinase

46 antithrombin blocked the formation of FGF-2-FGF receptor-1 ectodomain-heparin ternary complexes, and

47 in (FN), activates fibroblast growth factor (FGF) receptor-1 (FGFR1) independent of FGF ligand in liv

48 n of the catalytic tyrosine kinase domain of FGF-receptor-1 (FGFR1) is mediated by a sequential and p

49 r 2 (FGF-2) and its receptor tyrosine kinase FGF receptor 1c.

50 BetaKlotho physically interacts with FGF receptors 1c and 4, thereby increasing the ability o

51 SUM52, that exhibit amplified expression of FGF receptor 2 (FGFR2) and are dependent on continued FG

52 on Cre-mediated recombination to investigate FGF receptor 2 (Fgfr2) function in the postnatal mammary

53 FGF receptor 2 (FGFR2) has a significant role in the pro

54 Conditionally deleting one copy of FGF receptor 2 (FGFR2) in adult mouse airway basal cells

55 n fibroblast growth factor 10 (FGF10) and in FGF receptor 2 (FGFR2) in LADD syndrome.

56 Furthermore, deletion of Fgf receptor 2 (Fgfr2) in the epithelium also leads to s

57 mb development, we conditionally inactivated fgf receptor 2 (Fgfr2) in the mouse AER to terminate all

58 st on the endothelium, and downregulation of FGF receptor 2 (FGFR2) on PMNs rescued host defense in t

59 Aberrant activation of FGF receptor 2 (FGFR2) signaling, through overexpression

60 BSS is caused by mutations in the FGF receptor 2 (FGFR2), but the molecular mechanisms tha

61 ere, we present the crystal structure of the FGF receptor 2 kinases caught in the act of trans-phosph

62 fgf8 (fibroblast growth factor 8) and fgfr2 (fgf receptor 2) transcripts.

63 dy brings up the intriguing possibility that FGF receptor 2, in the oligodendrocyte/myelin compartmen

64 nockdown changes the alternative splicing of FGF receptor-2 (FGFR2) transcripts, altering the incorpo

65 hed, and fibroblast growth factor 10 (FGF10)/FGF receptor 2b (FGFR2b) signaling directly regulates th

66 revealed that the proximal tubule expresses FGF receptor 3 (FGFR3) but not FGFR1, FGFR2, or FGFR4.

67 Gain-of-function mutations in FGF receptor 3 (FGFR3) have been implicated in severe sk

68 FGF receptor 3 (FGFR3) is activated by mutation or over-

69 Overexpression of FGF receptor 3 (FGFR3) is implicated in the development

70 verexpression, or intensified signaling from FGF receptor 3, occurs in 70%-90% of these tumors in hum

71 on Sulf 1 and Sulf 2 expression, to control FGF receptor 3-IIIb-mediated astrocytic responses.

72 both short- and long-term assays through the FGF receptor 3/RAS/c-RAF/mitogen-activated protein kinas

73 ating mutations in fibroblast growth factor (FGF) receptor 3 and inactivating mutations in the NPR2 g

74 the expression of Fibroblast Growth Factor (FGF) Receptor 3 and responsiveness of progenitors to FGF

75 In contrast, the tyrosine kinase receptor FGF receptor-3 (FGFR3) and the transcription factor fork

76 lkaline phosphatase (Tnap) transcription via FGF receptor-3 (FGFR3) signaling, leading to inhibition

77 ism independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and interaction

78 e report that FGF19 and its cognate receptor FGF receptor 4 (FGFR4) are coexpressed in primary human

79 A stimulated tyrosine phosphorylation of the FGF receptor 4 (FGFR4) in hepatocytes.

80 nd gall bladder filling; FGF19 binds only to FGF receptor 4 (FGFR4), but its liver-specific activity

81 studies demonstrate that FGF signalling, via FGF receptor 4 (Fgfr4), mediates a signal-transduction p

82 corresponded with constitutive activation of FGF receptor 4 (FGFR4)-dependent ERK/AKT-p70S6K-S6 signa

83 FGF19 uniquely binds to FGF receptor 4 (FGFR4).

84 kdown of SCUBE3 in C2C12 myoblasts inhibited FGF receptor 4 expression and FGF signaling, thus result

85 broblast growth factor (FGF)19 signaling via FGF receptor 4 for survival were more sensitive to trame

86 al were more sensitive to trametinib than to FGF receptor 4 inhibitors.

87 Protein levels of FGF19, FGF receptor 4, FXR and short heterodimer partner were i

88 antagonizes transcription of the breathless FGF receptor, a known target of Trh in the tracheal syst

89 FGF receptor activation upregulates expression of these

90 ion as a co-factor permitting FGF21 mediated FGF receptor activation.

91 kinase-ERK signal transduction downstream of FGF receptor activation.

92 ha), a key link in fibroblast growth factor (FGF) receptor activation of ERK1/2.

93 ting up a gradient of CXCL12a, and trailing (FGF receptor active) cells moving actively by chemotaxis

94 nd link tissue subdivision (Wnt receptor and FGF receptor activity domains) to receptor-ligand parame

95 The Heartless FGF receptor acts cell-autonomously in ensheathing glia

96 Activating FGF receptors acutely had an antidepressant-like effect

97 data that show that an SMC deletion of a pan-FGF receptor adaptor Frs2alpha (fibroblast growth factor

98 e demonstrate that skin hyperplasia requires FGF receptor adaptor protein Frs2alpha and tyrosine phos

99 t2 interacts specifically with the activated FGF receptor and is required for a rapid phase of recept

100 from fibroblast growth factor (FGF) via the FGF receptor and its effectors in the Ras-MAPK pathway.

101 led to autocrine activation of Stat3 via the FGF receptor and JAK kinases, and pharmacological inhibi

102 the ability of VE-cadherin to associate with FGF receptor and the density-enhanced phosphatase-1 (Dep

103 ERK, which is sensitive to dominant-negative FGF receptor and to the inhibitors SU5402 and U0126, and

104 isolated lamprey homologs of FGF3, FGF8 and FGF receptors and asked whether these functions are ance

105 The FGF receptors and co-receptors for these three FGF molec

106 Using mice with tissue-specific ablation of FGF receptors and FGF receptor substrate 2alpha (Frs2alp

107 ressed in response to Wnt signaling activate FGF receptors and initiate proto-neuromast formation.

108 , which, respectively, activate cell surface FGF receptors and intranuclear FGFR1, to determine the r

109 This response is mediated by FGF receptors and involves the activation of IkappaBalph

110 expressed in thymic stromal cells along with FGF receptors and its obligate coreceptor, betaKlotho.

111 tion of Shh responses requires activation of FGF receptors and of ERK and JNK kinases, because it can

112 lying the control of transphosphorylation of FGF receptors and other receptor tyrosine kinases.

113 t physical interaction between the A(2A) and FGF receptors and the robust physiological consequences

114 r IHH-associated genes, including kal-1, the FGF receptor, and FGF.

115 tor cooperation between integrin beta(3) and FGF receptor, and triggered a downstream cascade includi

116 cient zebrafish embryos can be rescued by an FGF receptor antagonist SU5402.

117 The action of FGF receptors appears to be through increasing self-rene

118 at some of the FGF ligands together with the FGF receptors are altered in individuals with affective

119 rs2alpha-Shp2 complex and its recruitment to FGF receptors are crucial for downstream ERK signaling i

120 g several FGF ligands and the four classical FGF receptors are detectable in the lens-forming ectoder

121 to induce diabetes remission and that brain FGF receptors are potential pharmacological targets for

122 We find that FGF receptors are required for neural stem-cell maintena

123 inases and nonraft fibroblast growth factor (FGF) receptors are implicated in cell adhesion molecule-

124 road evidence that fibroblast growth factor (FGF) receptors are important in prostate cancer initiati

125 Mutations in fibroblast growth factor (FGF) receptors are responsible for a variety of skeletal

126 Because small molecule inhibitors of Fgf-receptors are in human clinical trials, this suggest

127 eptor tyrosine kinases (RTKs), including the FGF receptor, are TRIAD1 substrates that are possibly re

128 receptor substrate 2alpha (FRS2alpha) is an FGF receptor-associated protein required for activation

129 The in vivo data, together with FGF receptor binding analysis, indicate that the in vivo

130 d embryos with FGF8b blocking antibody or an FGF receptor blocker rescues secondary heart field myoca

131 ished animal model of CKD, treatment with an FGF-receptor blocker attenuated LVH, although no change

132 Moreover, in older mice, an activated FGF receptor can rescue the age-related decline in neuro

133 nents of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the hi

134 pertrophy of isolated rat cardiomyocytes via FGF receptor-dependent activation of the calcineurin-NFA

135 contribute to mesoderm heterogeneity via an FGF receptor-dependent positive feedback mechanism.

136 Furthermore, SU5402, an FGF receptor-dependent protein kinase inhibitor, inhibit

137 Expression of a dominant-negative FGF receptor (DN-Fgfr1), treatment with SU5402 (a pharma

138 The Caenorhabditis elegans FGF receptor, EGL-15, is alternatively-spliced to yield

139 Two inhibitors of the Fgf receptor elicited similar phenotypes, suggesting tha

140 blocked by expression of a dominant-negative Fgf receptor, epicardial EMT and coronary neovasculariza

141 Fgf receptor/Erk signalling is known to be required for

142 arised primitive endoderm layer requires the Fgf receptor/Erk signalling pathway.

143 vestigate the regulation of renal Klotho and FGF receptor (FEFR)-1 in healthy and uremic rats induced

144 We further demonstrate that Fgf receptor (Fgfr) 1 signaling within the developing se

145 -beta increased KL secretion and upregulated FGF receptor (FGFR) 1.

146 s renal phosphate reabsorption by activating FGF receptor (FGFR) 1c in a Klotho-dependent fashion.

147 th factor (FGF) 1 and FGF2 signaling through FGF receptor (FGFR) 1c.

148 e that directly targets cardiac myocytes via FGF receptor (FGFR) 4 thereby inducing hypertrophic myoc

149 Inhibitors of the FGF receptor (Fgfr) and ERK pathways reversed the skewed

150 t a functional FGF19 receptor may consist of FGF receptor (FGFR) and heparan sulfate complexed with e

151 which is essential for the formation of FGF2/FGF receptor (FGFR) and VEGF(165)/VEGF receptor signalin

152 d activating binary complexes composed of an FGF receptor (FGFR) bound to either alpha-Klotho or beta

153 be hijacked by disease-causing mutations in FGF receptor (FGFR) during embryogenesis.

154 We report high FGF receptor (FGFR) expression in 17.7% (11 of 62) of he

155 anterior neural plate via deletion of three FGF receptor (FGFR) genes.

156 or Nurr1 or expressing the dominant-negative FGF receptor (FGFR) identified orphan nuclear receptor N

157 We demonstrate that activation of Fgf receptor (Fgfr) induces intracellular Ras-MAPK, whic

158 This PDX model is highly sensitive to FGF receptor (FGFR) inhibition, and more so to combined

159 Finally, we examined anxiety behavior in FGF receptor (FGFR) KO mice; however, FGFR1, FGFR2, and

160 single-cell transcriptomics of wild-type and Fgf receptor (Fgfr) mutant embryos.

161 etic skeletal disorders caused by activating FGF receptor (FGFR) mutations.

162 g complex composed of alpha-Klotho (KLA) and FGF receptor (FGFR) resulting in kinase activation, regu

163 lectivity in their requirement for mediating FGF receptor (FGFR) signaling and activating downstream

164 We investigated the role of FGF receptor (Fgfr) signaling in Schwann cells and the c

165 Here we identify FGF receptor (FGFR) signalling as a critical regulator o

166 al activities by activation of transmembrane FGF receptor (FGFR) tyrosine kinases and their coupled i

167 Of the four FGF receptor (FGFR) tyrosine kinases, only FGFR4 is expr

168 indings indicate that CIMA-1 antagonizes the FGF receptor (FGFR), and does so most likely by inhibiti

169 multiprotein complex formation between FGF, FGF receptor (FGFR), and heparan sulfate proteoglycan on

170 (RTKs), such as EGF receptor (EGFR), ErbB-2, FGF receptor (FGFR), and many others, has been reported

171 Gs) via a ternary complex with FGF-2 and the FGF receptor (FGFR).

172 basic fibroblast growth factor 2 (FGF2b) and FGF receptor (FGFR)1 in LMC formation.

173 The migratory response was mediated by FGF receptors (FGFR) 1 and 3 and MAPK/ERK intracellular

174 a prototypical SH2 containing substrate, by FGF receptors (FGFR) entails formation of an allosteric

175 on, to act as coreceptors along with classic FGF receptors (FGFR) to mediate potent biologic activity

176 Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor pr

177 Deletion of three FGF receptors (Fgfr1-3) early in lens development demons

178 Four FGF receptors (FGFR1-4) have been cloned and characteriz

179 tabolism in target organs through activating FGF receptors (FGFR1-4).

180 ll-surface receptor composed of one of three FGF receptors (FGFR1c, FGFR2c or FGFR3c) in complex with

181 ct isoforms of the fibroblast growth factor (FGF) receptor FGFR2-IIIb and FGFR2-IIIc varying their ex

182 Among the four FGF receptors, FGFR2 showed two highly specific patterns

183 Of the four FGF receptors (FGFRs 1-4), FGFR1 and FGFR3 are strongly

184 tively spliced forms of four tyrosine kinase FGF receptors (FGFRs 1-4).

185 find that although both are able to activate FGF receptors (FGFRs) 1c, 2c, and 3c, only FGF19 activat

186 Whether FGF receptors (FGFRs) accomplish such varied tasks in pa

187 led that bone marrow stromal cells express 5 FGF receptors (FGFRs) among the 7 known FGFR subtypes.

188 Fibroblast growth factors (FGFs) and FGF receptors (FGFRs) are known for their potent effects

189 The FGF receptors (FGFRs) control a multitude of cellular pr

190 vels of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) have been detected in various neur

191 F signaling, with only three ligands and two FGF receptors (FGFRs) identified.

192 The functions of FGF receptors (FGFRs) in early development of the cerebr

193 role of fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in establishing and maintaining co

194 pecific fibroblast growth factors (FGFs) and FGF receptors (FGFRs) in NSCLC cell lines.

195 roblast growth factors (FGFs) signal through FGF receptors (FGFRs) mediating a broad range of cellula

196 (mKL) that forms heteromeric complexes with FGF receptors (FGFRs) to initiate intracellular signalin

197 ctor (FGF) signaling through cross-talk with FGF receptors (FGFRs), but the mechanism underlying the

198 predominant effector pathway downstream from Fgf receptors (Fgfrs), but these receptors can also sign

199 e, we show that distinct sets of overlapping FGF receptors (FGFRs), FGFR2b and FGFR1b, mediate excita

200 -23 (FGF-23) activates complexes composed of FGF receptors (FGFRs), including FGFR1, and alpha-Klotho

201 n may not form stable ternary complexes with Fgf receptors (FgfRs), it acts together with and/or is n

202 Because FGF9 and FGF10 activate distinct FGF receptors (FGFRs), we hypothesized that they would c

203 nly known ligand that signals to mesenchymal FGF receptors (FGFRs).

204 g of FGF19, FGF21 and FGF23 to their cognate FGF receptors (FGFRs).

205 inal phosphotyrosine-binding domain (PTB) to FGF receptors (FGFRs).

206 efinitive endoderm through activation of the FGF receptors (FGFRs).

207 verexpress dominant-negative forms of Bmp or Fgf receptors following heat-shock induction.

208 Here we show, however, that the FGF receptors form dimers in the absence of ligand, and

209 al for lens fiber differentiation, different FGF receptors function redundantly.

210 re, we show that conditional deletion of the FGF receptor gene Fgfr1 abolishes FGF signaling in the m

211 Here, three FGF receptor genes are simultaneously deleted during cor

212 Although ligands that activate FGF receptors have antidepressant and anxiolytic effects

213 Multiple gain-of-function mutations in FGF receptors have been implicated in a variety of sever

214 Fibroblast growth factor (Fgf) receptors have a recognized role in mammary ductal

215 Mutation of FGF receptor Heartless (Htl) has been shown to cause CVM

216 Null mutations in the FGF receptor heartless (htl), or its ligands, caused sig

217 (FGF) 8/17/18 subfamily, are ligands for the FGF receptor Heartless (Htl).

218 monstrate that the Fibroblast growth factor (FGF) receptor Heartless autonomously controls astrocyte

219 genetically engineered a model of inducible FGF receptor (iFGFR) signaling in the context of the wel

220 modulatory coligand with FGF to activate the FGF receptor in an HS-dependent manner.

221 able of binding and activating their cognate FGF receptor in vitro and in living cells.

222 the observation that DSTYK colocalizes with FGF receptors in the ureteric bud and metanephric mesenc

223 Here, we found that transgenic inhibition of Fgf receptors in uninjured zebrafish caused severe atrop

224 tic astrocyte in vivo, identifies a role for Fgf receptors in vertebrate astrocytes and establishes z

225 urnover of surface fibroblast growth factor (FGF) receptor, increased extracellular signal-regulated

226 network by which activating mutations in the FGF receptor inhibit bone growth.

227 Conversely, miR-133 antagonism during Fgf receptor inhibition accelerated regeneration through

228 t FGF2-mediated resistance is interrupted by FGF receptor inhibition.

229 ion was blocked by Fibroblast growth factor (Fgf) receptor inhibition, high miR-133 levels were quick

230 e studies with a Mek inhibitor, U0126, and a Fgf receptor inhibitor, SU5402, indicate that the timing

231 cell development in a manner similar to the FGF receptor inhibitor.

232 arly stages of cochlear development using an FGF receptor inhibitor.

233 uced by 80% by the fibroblast growth factor (FGF) receptor inhibitor PD173074 and by 70% by the IKK i

234 DU 145 cells, treatment with a pharmacologic FGF-receptor inhibitor or a neutralizing anti-FGFR1 anti

235 ES cells lacking Fgf4 or treated with FGF receptor inhibitors resist neural and mesodermal ind

236 d VEGF/platelet-derived growth factor (PDGF)/FGF receptor inhibitors, paracrine ERK activation in fib

237 on principle in both endocrine and paracrine FGF receptor interaction and activation.

238 Further understanding of FGF/receptor interactions may allow the development of e

239 sruption of matrix adhesion promotes uniform FGF receptor internalization and degradation while enhan

240 Here, we show that adhesion inhibits mitotic FGF receptor internalization, leading to receptor enrich

241 Therefore, while signaling by FGF receptors is essential for lens fiber differentiatio

242 n, and that combined inhibition of VEGF/PDGF/FGF receptors is sufficient to inhibit mitogenic signali

243 this case mediated by a transporter and the FGF receptor, is vital to preserve embryonically derived

244 FGFR4 is the major hepatic FGF receptor isoform and is responsible for the hepatic

245 The identity and location of the FGF receptor isotypes that mediate these effects are unc

246 FGF-receptor kinase inhibitors blocked these effects.

247 2alpha (FRS2), an adaptor protein that links FGF receptor kinases to multiple signaling pathways, med

248 Neuronal expression of the FGF receptor ligand Pyramus is also required for the gen

249 ressed genes, including multiple Wnt and ndk/FGF receptor-like (ndl/FGFRL) genes.

250 ns cell differentiation, it is unclear which FGF receptors mediate these processes during different s

251 Furthermore, through the activation of FGF receptor-mediated intracellular MAPK pathway, FGF16

252 This FGF receptor-mediated stimulation of mature oligodendroc

253 e found some directed dorsal migration in an FGF receptor mutant, which suggests that additional sign

254 Contrary to FGF receptor mutants that displayed loss of ERK signalin

255 y reported that the expression of activating FGF receptor mutations in osteoblasts downregulated the

256 fation-dependent FGF signaling mechanism via FGF receptors on astrocytes.

257 in the assembly of signaling complexes with FGF-receptors on the plasma membrane.

258 ing by expression of a constitutively active FGF receptor only partially rescued the lacrimal gland d

259 onditionally express an activated form of an FGF receptor or delete the FGF receptors that are expres

260 og or Dpp pathways, nor did Fas2 inhibit the FGF receptor or Torso, indicating specificity in the inh

261 402, or by activation of a dominant negative FGF receptor, or by activation of expression of the Wnt

262 activation of the fibroblast growth factor (FGF) receptor, phospholipase C (PLC), protein kinase C (

263 tral activation of fibroblast growth factor (FGF) receptors regulates peripheral glucose homeostasis

264 ction mutations in fibroblast growth factor (FGF) receptors result in chondrodysplasia and craniosyno

265 Pharmacologic blockade of FGF receptors resulted in a comparable increase in plasm

266 reveal a previously unrecognized function of FGF receptor signaling in oligodendrocytes that contribu

267 levels of proteins known to be regulated by FGF receptor signaling, but proteins known to be importa

268 FGF receptor signaling, in turn, inhibits Wnt signaling.

269 on to CB1 cannabinoid receptor regulation of FGF receptor signaling.

270 We used FGF-receptor signaling to identify EGR1 as a locus that

271 elicited similar phenotypes, suggesting that Fgf receptor signalling promotes Erk-mediated polarisati

272 d by PD173074, a small molecule inhibitor of FGF receptor signalling.

273 the actions of FGF19 on target tissues, its FGF receptor specificity, and the contributions of other

274 introducing endothelial-specific deletion of FGF receptor substrate 2 alpha (Frs2a) in atheroscleroti

275 issue-specific ablation of FGF receptors and FGF receptor substrate 2alpha (Frs2alpha) in heart proge

276 FGF receptor substrate 2alpha (FRS2alpha) is an FGF rece

277 FGF receptor substrate 2alpha (FRS2alpha) is an FGFR int

278 expression, and decreased phosphorylation of FGF receptor substrate 2alpha, a major FGF-23 receptor s

279 bility of FGF23 to induce phosphorylation of FGF receptor substrate and ERK in various types of cells

280 ch, unlike other FGF peptides, activates all FGF receptor subtypes.

281 inhibitors of YAP (such as verteporfin) and FGF receptors (such as BGJ398) can provide a novel thera

282 A dominant-negative form of the Ciona FGF receptor suppresses the formation of polarized actin

283 ivated form of an FGF receptor or delete the FGF receptors that are expressed in these cells.

284 aptic SDC2 presents FGF22 to the presynaptic FGF receptor to promote presynaptic differentiation.

285 d 4, thereby increasing the ability of these FGF receptors to bind FGF21 and activate the MAP kinase

286 that CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardiu

287 onal ablation of this receptor-type, but not FGF receptor type 1 (FGFR1), resulted in attenuation of

288 Here, we show that FGF receptor type 2 (FGFR2) is highly enriched at the pa

289 ritically important to identify the specific FGF receptor type and its downstream signaling molecules

290 activities by activating diverse isotypes of FGF receptor tyrosine kinases (FGFRs).

291 t into the signaling molecules downstream of FGF receptor tyrosine kinases in cardiac progenitors.

292 les that specifically inhibit GSK3, MEK, and FGF receptor tyrosine kinases.

293 ors associate with fibroblast growth factor (FGF) receptor tyrosine kinases (FGFRs) to enable signali

294 of VEGF, PDGF, and fibroblast growth factor (FGF) receptor tyrosine kinases.

295 Using a pharmacological inhibitor of the FGF receptor, we show that reducing FGF signalling parti

296 ural cell adhesion molecule (NCAM) activates FGF receptors, we asked whether peripherally administere

297 ctivation of brain fibroblast growth factor (FGF) receptors, we explored the antidiabetic efficacy of

298 ot targeted by Cre-mediated recombination of Fgf receptors, were also misplaced in FGFR DKO mice, pos

299 r tyrosine kinase receptors, such as EGF and FGF receptors, were not activated by GCs.

300 ted whether administering agents that act on FGF receptors would have antidepressant-like effects in