ライフサイエンスコーパス: FMO

1 FMO analysis is performed to estimate the perturbations

2 FMO analysis unveiled that the HOMO and LUMO of the two

3 FMO consists of three monomers arranged in C3 symmetry w

4 FMO data exhibited that TPD5 had the least E (1.71 eV) w

5 FMO enzymes (FMOs) play a key role in the processes of d

6 FMO gene and protein expression were also determined.

7 FMO investigation revealed that DOCD2 showed the least e

8 FMO methodology was successfully used as part of a ratio

9 FMO mutants, on the other hand, produced both hemiketal

10 FMO needs NADPH as a cofactor in addition to the prosthe

11 FMO provides a large fraction of the oxidizing necessary

12 FMO theory and distortion/interaction energy control hav

13 FMO theory has been used to rationalize the lack of regi

14 FMO-mediated TMAO formation was increased in CKD versus

15 FMOs are conserved in eukaryotes and induced by multiple

16 FMOs are well-conserved enzymes that are also induced by

17 FMOs might reduce the risk of phospholipidosis of CAD-li

18 on enzyme flavin-containing monooxygenase-2 (FMO-2).

19 n-assisted process for better donor-acceptor FMO overlap, the third oxidized Cu center in the trinucl

20 Among FMOs, GMV was positively associated with pain severity (

21 As part of the human genome effort, an FMO-like gene, FMO6, was identified between FMO3 and FMO

22 ve enzyme with characteristics typical of an FMO isoform.

23 ges resulting from altering the 3'-end of an FMO were investigated with human FMO3.

24 up pain-related correlations between FMN and FMO cohorts, less spinal cord GMV in the opioid-taking F

25 ates the longevity effectors DAF-2/IGF1R and FMO-2/FMO5.

26 DPH-binding sites, that are common to TR and FMO domains, abolishes all outputs.

27 nna-Matthews-Olson light-harvesting antenna (FMO) protein has been a model system for understanding p

28 e isoform-specific metabolism for human AOs, FMOs, and UGTs and general CYP metabolism for preclinica

29 s probably due to the degradation of the apo-FMO protein at different stages after it does not bind t

30 mine was used as a probe substrate to assess FMO activity.

31 sulfur atoms, SAC and SBC, were much better FMO substrates than those having the less nucleophilic s

32 to hinge on a very sensitive balance between FMO interactions, electrostatics, and steric effects.

33 imeric complex, and a linker pigment between FMO and the RC core.

34 opriate type of red blood cell lysis buffer, FMO or isotype controls to identify rare cell population

35 ich is opposite to what would be expected by FMO considerations.

36 ethylation as the major OCM flux modified by FMO-2 that is sufficient to recapitulate its longevity b

37 donor to acceptor via spacer was observed by FMO analysis which further supported by DOS and TDM.

38 N-oxide and S-oxide metabolites produced by FMOs are often active metabolites.

39 ng the Fenna-Matthews-Olson antenna complex (FMO) as a model system, theoretical studies incorporatin

40 ,5-bis(phenylethynyl)benzene shows congruent FMOs.

41 e reacts with enol ethers to deliver "contra-FMO" products with high yield, stereoselectivity, and re

42 re performed which showed slightly decreased FMO energy gaps due to ligand-metal charge transfer (LMC

43 n and also the implications of the decreased FMO/chlorosome stoichiometry are discussed in terms of t

44 dynamics in wild-type and cysteine-deficient FMO mutant proteins under both reducing and oxidizing co

45 iazine and exon 3- (exon 4 for FMO4) deleted FMOs were not able to catalyze the S- and N-oxygenation

46 or-acceptor substitution leads to a disjoint FMO pattern, while the parent 1,4-distyryl-2,5-bis(pheny

47 However, there are five C. elegans FMOs and five mammalian FMOs, and it is not known whethe

48 FMO enzymes (FMOs) play a key role in the processes of detoxification

49 vated nitrilimine-F(-) has high-lying filled FMOs.

50 rification and characterization of the first FMO protein variant generated via replacement of the est

51 fection survival, thus identifying the first FMO with innate immunity functions in animals.

52 sity is determined by the expression of five FMO genes, named FMO1 to FMO5, and their variants.

53 hers in the optical spectra calculations for FMO using ab initio site energies and excitonic coupling

54 A reduced slope (0.2-0.3) was found for FMO: this may be due to a different reaction mechanism i

55 However, in silico methods for FMO metabolism prediction are not yet available.

56 sion models and is a validated substrate for FMO-2.

57 Here, we present an overview of evidence for FMOs' involvement in aging and disease, discussing the b

58 bilizing, there is a decrease in the forward FMO interaction that is offsetting.

59 cts on the regioselectivity are derived from FMO orbital interactions and the extent of electron tran

60 these transcripts would encode a functional FMO enzyme.

61 dies were done with two selective functional FMO substrates, methimazole, and 10-(N,N-dimethylaminope

62 this activity extends to many drugs, giving FMOs high pharmacological relevance.

63 Most identified FMO splice variants either caused a frame-shift or lacke

64 body of recent evidence, however, implicates FMOs in aging, several diseases, and metabolic pathways.

65 emperature, which never has been observed in FMO.

66 evidence that quantum coherence survives in FMO at physiological temperature for at least 300 fs, lo

67 rsal and ventral horn GMVs, with less GMV in FMOs vs. controls.

68 was to elucidate the mechanism of increased FMO activity in CKD.

69 octylamine and human uremic serum increased FMO-mediated TMAO formation.

70 ell as emission spectroscopy from individual FMO complexes at low temperatures.

71 The individual FMO complexes are subjected to very fast spectral fluctu

72 electron microscopic structure of the intact FMO-RC apparatus from Chlorobaculum tepidum at 2.5 angst

73 Intestinal FMO-2 is also activated by dietary restriction (DR) and

74 ontrol reactivity because, while the inverse FMO interaction becomes more stabilizing, there is a dec

75 ealed, perhaps by other members of the large FMO family in this animal.

76 ryptophan is decreased in multiple mammalian FMO overexpression models and is a validated substrate f

77 are five C. elegans FMOs and five mammalian FMOs, and it is not known whether promoting longevity an

78 enes encoding putative homologs of mammalian FMOs, K08C7.2, K08C7.5, Y39A1A.19, F53F4.5 and H24K24.5,

79 nzymes are related to those of the mammalian FMOs, which oxygenate nucleophilic substrates, YUC6 oxyg

80 the mutant cells contain a much less mature FMO protein.

81 vity of the flavin-containing monooxygenase (FMO) can be modulated by a number of nitrogen-containing

82 In humans, flavin-containing monooxygenase (FMO) functional diversity is determined by the expressio

83 The flavin-containing monooxygenase (FMO) gene family is conserved and ancient with represent

84 including a flavin-containing monooxygenase (FMO) gene, fmo-2/FMO5.

85 A flavin-containing monooxygenase (FMO) produced by A. sativum (AsFMO) was previously propo

86 ase (ALDH), flavin-containing monooxygenase (FMO), and cytochrome P450 (CYP) enzymes.

87 a bacterial flavin-containing monooxygenase (FMO), is found widespread in marine bacteria and is resp

88 talyzed by a flavin-dependent monooxygenase (FMO) activity internal to the last module of the PKS.

89 one requires an FAD-dependent monooxygenase (FMO) PhnB, which catalyzes the C2 aromatic hydroxylation

90 t to increased hepatic flavin monooxygenase (FMO)-mediated TMAO formation.

91 s encoding flavin-containing monooxygenases (FMOs) 1 and 4 of man.

92 Flavin-containing monooxygenases (FMOs) are a conserved family of xenobiotic enzymes upreg

93 The flavin-containing monooxygenases (FMOs) are a family of five microsomal enzymes important

94 The flavin-containing monooxygenases (FMOs) are important for the oxidation of a variety of en

95 Flavin-containing monooxygenases (FMOs) are primarily studied as xenobiotic metabolizing e

96 Flavin containing monooxygenases (FMOs) are promiscuous enzymes known for metabolizing a w

97 Flavin-containing monooxygenases (FMOs) attach an oxygen atom to the insoluble nucleophili

98 UCCA (YUC) flavin-containing monooxygenases (FMOs) catalyze a rate-limiting step in auxin biosynthesi

99 pproaches, flavin-containing monooxygenases (FMOs) encoded by six tandem-repeat genes in the A. sesqu

100 oxidative flavin-containing monooxygenases (FMOs) to detoxify numerous and potentially deleterious x

101 scens) and flavin-containing monooxygenases (FMOs, from Schizosaccharomyces pombe and hog liver micro

102 and hepatic flavin-dependent monooxygenases (FMOs) efficiently oxidize TMA to TMAO.

103 onstitute a family of flavin monooxygenases (FMOs), with an important role in auxin (IAA) biosynthesi

104 cal, conserved YUCCA sequences: FATGY motif, FMO signature sequence, and FAD-binding and NADP-binding

105 l pi-pi* FMOs of C-C pi bonds or the pi-n(+) FMOs of heavier group 14 alkyne analogues.

106 indings suggest that metabolic activation of FMO-mediated TMAO formation is a novel mechanism that co

107 cros component correlates with the amount of FMO protein in the isolated RCC complex.

108 is enzyme displayed other characteristics of FMO enzymes, with rapid depletion of enzyme activity upo

109 Although gene and protein expression of FMO were not changed, metabolic activation elicited by o

110 The locations and extents of labeling of FMO on the native membrane in comparison with it alone a

111 Here we analyze the functional mechanism of FMO from Schizosaccharomyces pombe using the crystal str

112 rs in animals, and identify the mechanism of FMO regulation through NHR-49/PPAR-a during S. aureus in

113 YP79 gene losses and neofunctionalization of FMO-catalyzed biosynthesis of oximes in Darwin's orchid

114 xenobiotic-metabolising enzymes, examples of FMOs exist that have evolved to metabolise specific endo

115 o and in vivo assays confirm the function of FMOs in the oxime biosynthesis.

116 nal change in the oxidative half-reaction of FMOs.

117 he endogenous substrate(s) and regulation of FMOs.

118 rast, endogenous functions and substrates of FMOs are less well understood.

119 ic eigenstates for the Fenna-Matthews-Olson (FMO) antenna complex, which can be used to improve theor

120 e antenna complex, the Fenna-Matthews-Olson (FMO) antenna protein from green sulfur bacteria, complet

121 the membrane-attached Fenna-Matthews-Olson (FMO) antenna protein functions as a "wire" to connect th

122 their coupling in the Fenna-Matthews-Olson (FMO) bacteriochlorophyll complex, which is found in gree

123 ia (GSB), the trimeric Fenna-Matthews-Olson (FMO) complex mediates the transfer of light energy from

124 energy transfer in the Fenna-Matthews-Olson (FMO) complex of photosynthetic green sulphur bacteria, h

125 t-protein complex, the Fenna-Matthews-Olson (FMO) complex, is suggestive that quantum coherence might

126 rred to the RC via the Fenna-Matthews-Olson (FMO) complex.

127 of the widely studied Fenna-Matthews-Olson (FMO) light-harvesting complex.

128 riochlorophyll) of the Fenna-Matthews-Olson (FMO) photosynthetic pigment protein complex.

129 The Fenna-Matthews-Olson (FMO) pigment-protein complex from green sulfur bacteria

130 bronic coupling in the Fenna-Matthews-Olson (FMO) pigment-protein complex in green sulfur bacteria, r

131 ay of (3)Bchl a of the Fenna-Matthews-Olson (FMO) protein.

132 is transferred via the Fenna-Matthews-Olson (FMO) proteins to a homodimeric reaction center (RC).

133 mmetric and asymmetric Fenna-Matthews-Olson (FMO) trimers, combined with absorption difference anisot

134 rption difference anisotropy measurements on FMO trimers from the green bacterium Chlorobium tepidum,

135 -based pipeline uses Fluorescence Minus One (FMO) controls or distinct population differences to deve

136 ndividuals with fibromyalgia taking opioids (FMO, n = 27) and not taking opioids (FMN, n = 31).

137 Frontier molecular orbital (FMO) analysis and time-dependent density functional theo

138 insight from the frontier molecular orbital (FMO) analysis disclosed that central acceptors are respo

139 43 kcal/mol) and frontier molecular orbital (FMO) energy gaps.

140 d to the inverse frontier molecular orbital (FMO) interaction between the azadiene LUMO and alkene HO

141 nal study of the frontier molecular orbital (FMO) interactions and reaction profile thermodynamics in

142 particular, the frontier molecular orbital (FMO) of the Cu(I) site.

143 d donor-acceptor frontier molecular orbital (FMO) overlap.

144 The fragment molecular orbital (FMO) quantum-mechanical (QM) method provides a complete

145 Frontier molecular orbital (FMO) theory considering the 3-center-4-electron pai-syst

146 Frontier molecular orbital (FMO) theory is predicated in part on this concept.

147 ach based on the frontier molecular orbital (FMO) Theory.

148 e predictions of frontier molecular orbital (FMO) theory.

149 edictions of the frontier molecular orbital (FMO) theory.

150 in an unoccupied frontier molecular orbital (FMO) with correct orientation and distal O character for

151 estigations like frontier molecular orbital (FMO), absorption spectra (UV-Vis), density of states (DO

152 analyses such as frontier molecular orbital (FMO), absorption spectra, transition density matrix (TDM

153 ribution through frontier molecular orbital (FMO), optical absorption, reorganization energy, open ci

154 described by the frontier molecular-orbital (FMO) model.

155 e difference in frontier molecular orbitals (FMO) of the metal-oxo and substrate-oxo bonds.

156 lap between the frontier molecular orbitals (FMO).

157 Localization of frontier molecular orbitals (FMOs) along different axes of these cruciforms makes the

158 atrix (TDM) and frontier molecular orbitals (FMOs) analyses were accomplished to understand the NLO p

159 studies such as Frontier Molecular Orbitals (FMOs) and Molecular Electrostatic Potential (MEP) provid

160 s elucidate key frontier molecular orbitals (FMOs) and their contribution to H atom abstraction react

161 n the important frontier molecular orbitals (FMOs) for this reaction, the unoccupied beta-spin d(xz/y

162 the calculated frontier molecular orbitals (FMOs) of Ar(iPr(4))GaGaAr(iPr(4)) are of pi-pi symmetry,

163 bstituents, the frontier molecular orbitals (FMOs) of these cruciforms are either congruent, i.e., HO

164 nalysis such as frontier molecular orbitals (FMOs), density of states (DOS), transition density matri

165 V-Vis analysis, frontier molecular orbitals (FMOs), transition density matrix (TDM), natural bond orb

166 ons such as the frontier molecular orbitals (FMOs), UV-Visible, density of states (DOS), transition d

167 to distinctive frontier molecular orbitals (FMOs).

168 dox-active dpi* frontier molecular orbitals (FMOs).

169 g regions compared with those encoding other FMO isoforms.

170 imazole, a flavin-containing mono-oxygenase (FMO) substrate, inhibited S-oxidation of all four conjug

171 talyzed by flavin-containing mono-oxygenase (FMO; refs 7,8), and tissue localization and functional s

172 ns with M06/6-311G(d,p) method by performing FMO, UV-Vis, QTAIM and global reactivity parameters eluc

173 isotropy and oxo donor strength that perturb FMOs and affect reactivity.

174 reactions than permitted by the usual pi-pi* FMOs of C-C pi bonds or the pi-n(+) FMOs of heavier grou

175 tions along the same mechanistic pathway (pi-FMO pathway) with similar reactivity but also have an ad

176 onserved cysteine residue (Cys-85) preserves FMO but suppresses TR activity and stress tolerance, whe

177 fluorescence, and CD spectra of the purified FMO variant protein are similar to those of the wild-typ

178 Sequence analysis of this putative FMO family member revealed nothing that would a priori a

179 ated as substrates for cDNA-expressed rabbit FMO isoforms FMO1, FMO2, FMO3, and FMO5.

180 fy HLH-30/TFEB as its main regulator, reveal FMOs as important innate immunity effectors in animals,

181 y protein subunits (PscE and PscF), a second FMO trimeric complex, and a linker pigment between FMO a

182 The spatially separated FMOs permit the independent manipulation of the HOMO and

183 e unoccupied alpha-spin d(z2) orbital (sigma-FMO pathway).

184 The corresponding simple FMO analyses of Type III cycloadditions do not correctly

185 The smaller FMO-LUMO gap promotes a rapid nucleophilic attack and ov

186 holipidosis of CAD-like drugs, although some FMOs metabolites seem to be neurotoxic and hepatotoxic.

187 e of approximately 20 s whereas that of some FMOs is >30 min.

188 ne derivatives with energetically stabilized FMOs.

189 ts validity for the case of the much-studied FMO dynamics as well as the canonical spin-boson model.

190 In this study, FMO enzyme activity experiments were conducted in vitro

191 ictographs and TDMs heat maps also supported FMO results, corroborating the presence of charge separa

192 n simulations based on a threefold-symmetric FMO protein.

193 bolic pathway, SfnG serves as the initial TC-FMO for sulfur assimilation, which is investigated in de

194 nfiguration from other tetrameric class C TC-FMOs.

195 omponent flavin-dependent monooxygenases (TC-FMOs) from the msu and sfn operons to assimilate sulfur

196 g the excitons within the Chlorobium tepidum FMO complex at 77 K.

197 o the transition state geometry, rather than FMO interactions or reaction thermodynamics, controls re

198 We find that FMO interactions do not control reactivity because, whil

199 = OMe, Me, CO 2Me, Cl, CN) and reveals that FMO interaction energies between the 1,3-dipole and the

200 These results show that FMO isoforms can catalyze cysteine conjugate S-oxidation

201 We propose that FMOs exist in the cell as a complex with a reduced form

202 Because these results suggested that FMOs were the major catalysts of SBC, SAC, and DCVC sulf

203 The FMO activator octylamine and human uremic serum were eva

204 The FMO analysis revealed that all the derivatives exhibit l

205 The FMO modularity revealed here may be important in the evo

206 The FMO protein still assembles with the modified pigment, b

207 The FMO-RC apparatus presents an asymmetric architecture and

208 k demonstrates the power of going beyond the FMO approximation in designing advanced molecular materi

209 With the exception of FMO5, the FMO are encoded within a single gene cluster on human ch

210 spectra further reveals that "site 5" in the FMO complex plays a distinct role from other sites.

211 r two low-energy bacteriochlorophylls in the FMO protein from Chlorobaculum tepidum Removal of these

212 0/P840(+) from the decay of (3)Bchl a in the FMO protein.

213 Nonetheless, the FMO protein is able to quench energy transfer in aerobic

214 lectronic spectroscopy investigations of the FMO bacteriochlorophyll complex, and obtain direct evide

215 that probes solvent-exposed surfaces of the FMO by labeling solvent-exposed aspartic and glutamic ac

216 stem, we find that when certain sites of the FMO complex are subject to either the suppression of int

217 able one to calculate the Hamiltonian of the FMO complex in the site basis by fitting to the experime

218 al peaks in the 2D rephasing spectrum of the FMO complex obscure all but one of the crosspeaks at 77

219 duced, local defects or modifications of the FMO complex, and allows access to both the local and glo

220 e previously reported for this member of the FMO family of man.

221 efforts to characterize this isoform of the FMO gene family.

222 rolled to a great extent by two areas of the FMO primary structure (residues 381-432 and 433-465).

223 The assembly of the FMO protein and also the implications of the decreased F

224 ) and give information on the packing of the FMO protein in its native environment.

225 The smaller amount of the FMO protein in the mutant cell is probably due to the de

226 architecture for in vivo interactions of the FMO protein, the CM, and the chlorosome, ensuring highly

227 peptides show that the Bchl a #3 side of the FMO trimer interacts with the CM, which is consistent wi

228 electronic spectroscopy measurements on the FMO complex under both oxidizing and reducing conditions

229 ccessible by single-molecule techniques, the FMO complex exhibits ergodic behaviour.

230 siological temperature, and suggest that the FMO complex may work as a rectifier for unidirectional e

231 e instead of an epoxide, indicating that the FMO is involved in epoxidation rather than Baeyer-Villig

232 ial and temporal dynamics of EET through the FMO complex at physiological temperature are investigate

233 ed by the chlorosome is funneled through the FMO to the RC.

234 ductase activity (TR) that overlaps with the FMO domain involved in IAA biosynthesis.

235 The FMOs are more active than cytochromes in the brain and w

236 ng the HOMO-LUMO band gaps obtained from the FMOs study.

237 l for FMO3, the most relevant isoform of the FMOs in humans.

238 These studies experimentally probe the FMOs involved in the reactivity of FeIV=O (S = 1) model

239 Our results indicate that the FMOs and band gaps of benzobisoxazoles can be readily mo

240 o-dimensional (2D) Kagome lattices using the FMOs of NHC-Au-NHC junctions to create low-dimensional m

241 It is not clear whether these FMO splice variants can oxygenate other substrates, incl

242 We designate these FMOs as orchid oxime synthases 1-6.

243 bond and understand the contribution of this FMO to the low barrier of this reaction and how the geom

244 We apply the NNM to the entire trimeric FMO complex and find evidence for the existence of nonli

245 an asymmetric architecture and contains two FMO trimers that show different interaction patterns wit

246 The two FMO trimeric complexes establish two different binding i

247 orophyll (BChl) is located in one of the two FMO-PscA interfaces, leading to differential efficiencie

248 The differential contribution of the two FMOs to chlorination versus hydroxylation selectivity in

249 rotein are similar to those of the wild-type FMO protein except the conformations of most pigments ar

250 All previous studies have utilized wild-type FMO proteins from several species.

251 The structure of the wild-type FMO revealed that the prosthetic group FAD is an integra

252 It displayed typical FMO activities as demonstrated by oxygenating benzydamin

253 The structure harbors typical FMO aspects with the flavin adenine dinucleotide and NAD

254 model to a series of compounds with unknown FMO metabolism is also reported.

255 the electrocyclizations was confirmed using FMO, QTAIM, NICS, and ACID methods.

256 The variant FMO protein is less thermally stable than the wild type.

257 The excited-state lifetime of the variant FMO protein is unchanged from that of the wild type and

258 lassical correlations of rate constants with FMO energies or ionization potentials.