ライフサイエンスコーパス: FMRFamide

1 r can account for the acceleratory effect of FMRFamide.

2 hanges in excitability differed for 5-HT and FMRFamide.

3 s) are bidirectionally modulated by 5-HT and FMRFamide.

4 des, which are not evolutionarily related to FMRFamide.

5 concentration tested, nor does it recognize FMRFamide.

6 six Tv neurons express the neuropeptide gene FMRFamide.

7 dentified by sera against the neuromodulator FMRFamide.

8 ' currents with the higher concentrations of FMRFamide.

9 seen following application of high doses of FMRFamide.

10 penings was shorter with FLRFamide than with FMRFamide.

11 jump muscle which expresses the receptor for FMRFamides.

12 und only FMRFamide- and HA immunoreactivity (FMRFamide: 4 optic ganglion cells, 4-5 hair cells; HA: 3

13 ally and in the periphery, the FRFamides and FMRFamide act in distinct ways, apparently through disti

14 ests that RFamide neuropeptides activate the FMRFamide-activated Na(+) channels (FaNaCs) of invertebr

15 Moreover, we demonstrated that FMRFamide activates a previously undetected K+ current (

16 Pharmacological data show that FMRFamide acts directly on the chromatophore muscles.

17 The FMRFamide analogues FLRFamide and WnLRFamide were more e

18 ualitatively different from that produced by FMRFamide analogues with no obvious occurrence of subcon

19 The natural peptides FMRFamide and FLRFamide only activated unitary currents

20 B3 and B38 express the neuropeptides FMRFamide and the small cardioactive peptides (SCPs), re

21 monstrate the presence of both FRFamides and FMRFamide and their release, probably from the processes

22 Ichthyomyzon unicuspis, by using antisera to FMRFamide and to four forms of GnRH.

23 hich is stimulated by Phe-Met-Arg-Phe-amide (FMRFamide) and dopamine.

24 atory peptides, Phe-Met-Arg-Phe-NH(2)-amide (FMRFamide) and gastrin cholecystokinin, demonstrate that

25 ctivity to the peptides Phe-Met-Arg-Phe-NH2 (FMRFamide) and gonadotropin-releasing hormone (GnRH).

26 ped with PDFLAs that mostly colocalized PDF, FMRFamide, and 5-HT immunoreactivities, and with termina

27 aining form of small cardioactive peptide B, FMRFamide, and another D-amino acid-containing peptide f

28 NaCs are activated by the short neuropeptide FMRFamide, and HyNaCs by Hydra RFamides, which are not e

29 Instead, we found only FMRFamide- and HA immunoreactivity (FMRFamide: 4 optic g

30 ot all (~2,500) neurons, that are labeled by FMRFamide antibody are different from those revealed by

31 FMRFamide application causes contraction of chromatophor

32 ation kinetics of ICa,L were not affected by FMRFamide application, nor by internal perfusion with GT

33 rsor protein and show that the FRFamides and FMRFamide are derived from different precursors.

34 FMRFamides are evolutionarily conserved neuropeptides th

35 t of synapses and the inhibitory transmitter FMRFamide at another, long-term facilitation is blocked

36 The FMRFamide-binding site in FaNaCs was recently identified

37 These data indicate that FMRFamide can modulate ICa,L, but not ICa,T, in squid he

38 iously observed modulation of K+ currents by FMRFamide cannot account for this acceleratory effect in

39 Amidated neuropeptides of the FMRFamide class regulate numerous physiological processe

40 or N-AcFnLRFamide was co-applied with a low FMRFamide concentration.

41 Together, the FRFamides and FMRFamide convert feeding motor programs from ingestive

42 osuppressin, short neuropeptides F, extended FMRFamides], crustacean cardioactive peptide, tachykinin

43 tivities of FaRPs encoded by D. melanogaster FMRFamide (dFMRFamide), myosuppressin (Dms), and sulfaki

44 C expressed in oocytes was less sensitive to FMRFamide (EC(50) = 70 microM) than HaFaNaC (EC(50) = 2

45 ress numerous neuropeptides including kinin, FMRFamides, eclosion hormone (EH), crustacean cardioacti

46 ction of chromatophore muscles; however, the FMRFamide effect is slower and longer lasting than that

47 nserved zfh1 homeodomain binding site in the FMRFamide enhancer.

48 rous/squeeze misexpression, triggers ectopic FMRFamide expression in peptidergic neurons.

49 gether with apterous and squeeze to activate FMRFamide expression.

50 Continuous application of a concentration of FMRFamide from 30 microM to 1 mM resulted in a reduction

51 ned a cDNA encoding a Phe-Met-Arg-Phe-NH(2) (FMRFamide)-gated Na(+) channel from nervous tissue of th

52 rtial inhibition of current flow through the FMRFamide- gated channel by some part of the agonist or

53 colon, lung, kidney, and tongue, a molluscan FMRFamide-gated channel (FaNaC), and the nematode degene

54 by HtFaNaC is 65 % identical to that of the FMRFamide-gated channel cloned from Helix aspersa (HaFaN

55 FMRFamide-gated channels were also blocked by guanidiniu

56 The Drosophila FMRFamide gene encodes multiple FMRFamide-related peptid

57 indicate that the products of the Drosophila FMRFamide gene function as neurohormones to modulate the

58 FMRFamide-immunopositive cells are present in the poster

59 Many FMRFamide-immunopositive cells in the posterior chromato

60 r branches, leading ultimately to a two-part FMRFamide-immunoreactive plexus and an apparently separa

61 r in the tissue, associated with part of the FMRFamide-immunoreactive plexus.

62 A fifth bipolar neuron type (tubulin- and FMRFamide-immunoreactive) occurred deeper in the tissue,

63 ls, respectively, were mimicked by exogenous FMRFamide in culture (in vitro), implicating this or a r

64 ilies of RFamide peptides, the FRFamides and FMRFamide, in the central neuronal circuitry and the per

65 FMRFamide induced a substantial block of the L-type calc

66 FMRFamide induced an increase in the amplitude of the L-

67 ine-methionine-arginine-phenylalanine-amide (FMRFamide)-induced LTD.

68 hosphate) (GDPbetaS, 100 microM) reduced the FMRFamide-induced inhibition of the peak Ca2+ current.

69 of the Ca2+ current and occluded any further FMRFamide-induced inhibition.

70 y internal perfusion with GTPgammaS, and the FMRFamide-induced reduction in ICa,L was not relieved by

71 non-hydrolysable GTP analogue, mimicked the FMRFamide inhibition of the Ca2+ current and occluded an

72 t late larval expression of the neuropeptide FMRFamide is dependent on correct levels of Zfh1 and tha

73 Phe-Met-Arg-Phe-NH2 (FMRFamide)-like peptides (FLPs) are the largest neuropep

74 These properties include complex patterns of FMRFamide-like (FaRP) neuropeptides, serotonin (5HT) and

75 n summary, we did not observe either GnRH or FMRFamide-like immunoreactivity in the olfactory regions

76 We found cells with FMRFamide-like immunoreactivity in the preoptic area and

77 l behaviors, we explored the function of the FMRFamide-like neuropeptide (flp) gene family in regulat

78 The FMRFamide-like neuropeptide FLP-1, released by AVK, regu

79 nhibited by the neuronal release of a second FMRFamide-like neuropeptide, FLP-9, which functions thro

80 t of them, around the rim, also expresses an FMRFamide-like neuropeptide.

81 s requires ALA depolarization and release of FMRFamide-like neuropeptides encoded by the flp-13 gene.

82 Conformational properties of several similar FMRFamide-like neuropeptides from mollusks were investig

83 here identified a major biological role for FMRFamide-like neuropeptides in nematodes, and we sugges

84 n the nematode, and for normal expression of FMRFamide-like neurotransmitters in the AVK interneurons

85 Parental FMRFamide-like peptide signaling dampens oxidative stres

86 In the nematode Caenorhabditis elegans, FMRFamide-like peptides (FaRPs) are expressed in at leas

87 Nematode FMRFamide-like peptides (FLPs) are one of the most diver

88 The central role of FMRFamide-like peptides (FLPs) in nematode motor and sen

89 pment of the NMJ and expression of myoactive FMRFamide-like peptides in specific central neurons, the

90 It does not recognize 35 other AF (A. suum FMRFamide-like) peptides at the highest concentration te

91 FMRFamide, MLD/pedal peptide, allatotropin, RNamide, exc

92 The FMRFamide-modulated increase in ICa,L seen in the type I

93 Specifically, FMRFamide neurons are activated during pre-ecdysis; EH,

94 located in the thoracic ganglion expressing FMRFamide NPs (FMRFa(G6P) neurons) are necessary and suf

95 neurones high doses of Phe-Met-Arg-Phe-NH2 (FMRFamide) often evoke biphasic inward whole-cell curren

96 Similar effects were seen with FMRFamide on FaNaC expressed in oocytes.

97 (Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe amide) and FMRFamide (Phe-Met-Arg-Phe amide) generated no current o

98 s on a pheromone-sensing neuron and neuronal FMRFamide (Phe-Met-Arg-Phe)-like peptides.

99 The FMRFamide (Phe-Met-Arg-Phe-amide)-related neuropeptide g

100 FMRFamide (Phe-Met-Arg-Phe-amide, FMRFa) and similar neu

101 FMRFamide (Phe-Met-Arg-Phe-NH2) and related peptides (Fa

102 The endogenous neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) can accelerate the oscil

103 The actions of the neuropeptide FMRFamide (Phe-Met-Arg-Phe-NH2) on the L-type (ICa,L) an

104 The family of FMRFamide (Phe-Met-Arg-Phe-NH2)-like neuropeptides (FaRP

105 ective for processing endogenously expressed FMRFamide (Phe-Met-Arg-Phe-NH2)-related peptides (FaRPs)

106 We map the expression of the FRFamide and FMRFamide precursors in the feeding circuitry using in s

107 ular family of GPCRs (Rhodopsin neuropeptide FMRFamide-receptor-like genes) shows a remarkable expans

108 , cell bodies of SNs expressed both 5-HT and FMRFamide receptors that modulate excitability.

109 subset of neurons expresses the neuropeptide FMRFamide related (Fmrf).

110 Ligands for EGL-6 are Phe-Met-Arg-Phe-NH(2) (FMRFamide)-related peptides encoded by the genes flp-10

111 e to selectively regulate the secretion of a FMRFamide-related neuropeptide (FLP-1) from a pair of in

112 d this information back into the CNS via the FMRFamide-related neuropeptide FLP-21 and its cognate re

113 Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the f

114 Evidence is also presented suggesting that FMRFamide-related peptides (FaRPs) also function as neur

115 FMRFamide-related peptides (FaRPs) are a large group of

116 FMRFamide-related peptides (FaRPs) contain a C-terminal

117 eptor (GPCR) (C10C6.2) as a receptor for the FMRFamide-related peptides (FaRPs) encoded on the flp15

118 latostatins A, B, C, SIFamide, allatotropin, FMRFamide-related peptides [myosuppressin, short neurope

119 Allatostatin A, allatotropin, SIFamide, FMRFamide-related peptides, short neuropeptide F, myoinh

120 t least 18 genes that may encode 53 distinct FMRFamide-related peptides.

121 e Drosophila FMRFamide gene encodes multiple FMRFamide-related peptides.

122 thane, the inhibitory responses to exogenous FMRFamide remained unchanged.

123 -N-isopropyl)-amiloride (EIPA), enhanced the FMRFamide response in oocytes expressing HtFaNaC cRNA.

124 The amplitude of the FMRFamide response of HtFaNaC was increased by reducing

125 Here, we show that FMRFamide signaling from the nervous system is critical

126 is study reveals a function for two opposing FMRFamide signaling pathways in controlling the rhythmic

127 Using amperometry and FMRFamide tagging, I simultaneously measure the secretio

128 s and in some patches were more sensitive to FMRFamide than expressed HtFaNaC.

129 he greater whole-cell response observed with FMRFamide than with FLRFamide results mostly from a slow

130 With FMRFamide, the open probability (Po) of the channel was

131 rmine halothane' 5 site of action, exogenous FMRFamide was applied to both PeA(E) and PeA(I) cells in

132 ility decreases in SNs were evoked only when FMRFamide was applied to regions along the L7 axon with

133 aptic efficacy were evoked only when 5-HT or FMRFamide was applied to regions with SN varicosities al

134 The inhibitory effects of FMRFamide were abolished by pre-incubation of the cells

135 olished, whereas the inhibitory responses to FMRFamide were maintained and enhanced in duration in 1%

136 othane, the excitatory responses produced by FMRFamide were substantially reduced or abolished, where

137 olism becomes anaerobic in ischaemia) and by FMRFamide (which may mimic the action of related mammali